Initial Simulaton

The initial simulation is setup when the CNOW_run.hoc file is loaded. The simulation will show a high frequency alternating current (HFAC) blocking a test stimulus. The setup is as follows:

The electrode:

There is one electrode set to give a 10kHz sine wave at an amplitude of 1x10^6 nA. With an offset of 1x10^6 nA. The pulse train will begin 10ms into the simulation, and will continue for 100ms (the preset length of the simulation).

The test pulse:

The test pulse is given at an amplitude of 10nA that will be applied for .1ms after 40ms have passed in the simulation.

The model:

This simulation uses the MRG model, with 101 axon nodes.

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Here is what will happen during the simulation:

The first image shows the initial spikes that occur when the electrode is turned on. This eventually stops, and you can see all the spikes that have appeared on the spike plot (the second image). The third image shows the stimulus pulse immediately after the pulse was generated (essentially t is just barely greater than 40ms). When the test travels to where the stimulation is being applied what happens? You should observe that the action potential (AP) generated by the test stimulus is blocked by the HFAC. Now that you have seen the power that HFAC has on blocking APs, try changing various parameters, and see what works and what doesn't.