Pyramidal tract neurons are the most direct output to muscles from the primary motor cortex (M1). Liqiang Chu et al (2021) have shown that layer 5 pyramidal tract neurons (PT5B) decrease in excitability in parkinsonian as compared with control M1 in mice treated with 6-OHDA. We built this simulation, based on a detailed motor cortex implementation in NetPyNE, to see how the changed PT5B neuron excitability changes M1 spiking dynamics.
NetPyNE is a Python package for creating biological neural networks using the NEURON simulator.
Get the preprint Donald W. Doherty et al. (2024).
This research was funded by Aligning Science Across Parkinson's [ASAP-020572] through the Michael J. Fox Foundation for Parkinson's Research (MJFF).
cfg.ihGbar = 0.75
gbar = 0.0055 # nap # all secs
gpeak = 7.251280172010002e-05 # kBK # soma only
cfg.gnafbar = 0.00086 # NaT # all secs
cfg.ratesLong = {'TPO': [0,5], 'TVL': [0,2.5], 'S1': [0,5], 'S2': [0,5], 'cM1': [0,2.5], 'M2': [0,2.5], 'OC': [0,5]}
cfg.ihGbar = 0.75
gbar = 0.0055 # nap # all secs
gpeak = 7.251280172010002e-04 # kBK # soma only
cfg.gnafbar = 0.0172 # NaT # all secs
cfg.ratesLong = {'TPO': [0,5], 'TVL': [0,2.5], 'S1': [0,5], 'S2': [0,5], 'cM1': [0,2.5], 'M2': [0,2.5], 'OC': [0,5]}
cfg.ihGbar = 0.25
gbar = 0.0055 # nap # all secs
gpeak = 7.251280172010002e-05 # kBK # soma only
cfg.gnafbar = 0.00086 # NaT # all secs
cfg.ratesLong = {'TPO': [0,10], 'TVL': [0,10], 'S1': [0,5], 'S2': [0,5], 'cM1': [0,2.5], 'M2': [0,2.5], 'OC': [0,5]}
cfg.ihGbar = 0.25
gbar = 0.0055 # nap # all secs
gpeak = 7.251280172010002e-04 # kBK # soma only
cfg.gnafbar = 0.0172 # NaT # all secs
cfg.ratesLong = {'TPO': [0,10], 'TVL': [0,10], 'S1': [0,5], 'S2': [0,5], 'cM1': [0,2.5], 'M2': [0,2.5], 'OC': [0,5]}