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Expand Up @@ -7,40 +7,41 @@ @PHDTHESIS{Attia2021-fy
catalysis and separations. Recently, additive manufacturing has
allowed for the design of structured mesoscale porous structures,
including open cellular structures and lattices,which can be used
for applications ranging from biomedical implants to drug
delivery to aeroelastic wing design. These structures have also
garnered interest as a means to generate ordered porous media
which can exhibit desired surface properties and imparts
predictability. However, limited work has investigated the flow
dynamics through these structures. This thesis leveraged
computational fluid dynamics (CFD) as a tool to simulate fluid
flow through open cellular structures. The flow phenomena through
individual unit cells was investigated, and flow conditioning
through unit cell pores was observed. The influence of unit cell
geometry and flow conditions on pressure drop was also
investigated for cubic unit cells. Theoretical model fits were
evaluated, and it was found that the Darcy-Weisbach model may be
a useful tool to evaluate pressure drop over individual unit
cells. Pressure drop was shown to be decoupled for cubic unit
cells under laminar flow in lattice structures, suggesting the
feasibility of implementing optimization for the design of
lattice structures with specific flow dynamics. Finally, a
portable optimization workflow was developed to optimize lattice
designs with a minimum pressure drop.",
for applications ranging from biomedical implants to drug delivery
to aeroelastic wing design. These structures have also garnered
interest as a means to generate ordered porous media which can
exhibit desired surface properties and imparts predictability.
However, limited work has investigated the flow dynamics through
these structures. This thesis leveraged computational fluid
dynamics (CFD) as a tool to simulate fluid flow through open
cellular structures. The flow phenomena through individual unit
cells was investigated, and flow conditioning through unit cell
pores was observed. The influence of unit cell geometry and flow
conditions on pressure drop was also investigated for cubic unit
cells. Theoretical model fits were evaluated, and it was found
that the Darcy-Weisbach model may be a useful tool to evaluate
pressure drop over individual unit cells. Pressure drop was shown
to be decoupled for cubic unit cells under laminar flow in lattice
structures, suggesting the feasibility of implementing
optimization for the design of lattice structures with specific
flow dynamics. Finally, a portable optimization workflow was
developed to optimize lattice designs with a minimum pressure
drop.",
month = may,
year = 2021,
school = "University of Delaware",
keywords = "Flow dynamics; Cellular structures; Porous media; Darcy-Weisbach
model;Website",
pdf = {LMA_Thesis.pdf},
preview = {thesis.PNG}
model",
school = "University of Delaware"
}

@ARTICLE{Woodward2021-ka,
title = "Scalable 3D-printed lattices for pressure control in fluid
title = "Scalable {3D}-printed lattices for pressure control in fluid
applications",
author = "Woodward, Ian R and Attia, Lucas and Patel, Premal and Fromen,
author = "Woodward, Ian R and Attia, Lucas M and Patel, Premal and Fromen,
Catherine A",
journal = "AIChE J.",
volume = 67,
number = 12,
abstract = "Additive manufacturing affords precise control over geometries
with high degrees of complexity and pre-defined structure.
Lattices are one class of additive-only structures which have
Expand All @@ -56,35 +57,32 @@ @ARTICLE{Woodward2021-ka
that a single correlation can describe pressure behavior for
different lattice geometries and scales. Furthermore, combining
lattice systems in series has a complex effect that is sensitive
to part geometry. Together, these developments support the
promise for tailored, modular lattice systems at laboratory
scales and beyond.",
journal = "AIChE J.",
volume = 67,
number = 12,
to part geometry. Together, these developments support the promise
for tailored, modular lattice systems at laboratory scales and
beyond.",
month = dec,
year = 2021,
keywords = "3D printing; Fluid Mechanics; Transport Phenomena; lattices; open
cellular structures; pressure drop; scaling;Website",
language = "en",
pdf = {Scalable 3D-printed lattices for pressure control in fluid applications.pdf},
preview = {pressure.PNG}
cellular structures; pressure drop; scaling",
language = "en"
}

@ARTICLE{Attia2023-bc,
title = "Orthogonal Gelations to Synthesize {Core-Shell} Hydrogels Loaded
with {Nanoemulsion-Templated} Drug Nanoparticles for Versatile
Oral Drug Delivery",
title = "Orthogonal Gelations to Synthesize Core-Shell Hydrogels Loaded
with Nanoemulsion-Templated Drug Nanoparticles for Versatile Oral
Drug Delivery",
author = "Attia, Lucas and Chen, Liang-Hsun and Doyle, Patrick S",
journal = "Adv. Healthc. Mater.",
pages = "e2301667",
abstract = "Hydrophobic active pharmaceutical ingredients are ubiquitous in
the drug development pipeline, but their poor bioavailability
often prevents their translation into drug products. Industrial
processes to formulate hydrophobic APIs are expensive, difficult
to optimize, and not flexible enough to incorporate customizable
drug release profiles into drug products. Here, a novel,
dual-responsive gelation process that exploits orthogonal
thermo-responsive and ion-responsive gelations is introduced.
This one-step ``dual gelation'' synthesizes core-shell
thermo-responsive and ion-responsive gelations is introduced. This
one-step ``dual gelation'' synthesizes core-shell
(methylcellulose-alginate) hydrogel particles and encapsulates
drug-laden nanoemulsions in the hydrogel matrices. In situ
crystallization templates drug nanocrystals inside the polymeric
Expand All @@ -101,35 +99,32 @@ @ARTICLE{Attia2023-bc
suggests and applies a novel method to leverage orthogonal gel
chemistries to generate functional core-shell hydrogel particles.
This article is protected by copyright. All rights reserved.",
journal = "Adv. Healthc. Mater.",
pages = "e2301667",
month = jul,
year = 2023,
keywords = "drug delivery; hydrogels; nanocrystals; nanoemulsions;
stimuli-responsive materials;Website;md\_paper",
language = "en",
pdf = {Adv Healthcare Materials - 2023 - Attia.pdf},
preview = {TOC.png}
stimuli-responsive materials",
language = "en"
}

% The entry below contains non-ASCII chars that could not be converted
% to a LaTeX equivalent.
@ARTICLE{Jarai2020-tn,
title = "Evaluating {UiO-66} {Metal-Organic} Framework Nanoparticles as
{Acid-Sensitive} Carriers for Pulmonary Drug Delivery
Applications",
title = "Evaluating {UiO}-66 Metal-Organic Framework Nanoparticles as
Acid-Sensitive Carriers for Pulmonary Drug Delivery Applications",
author = "Jarai, Bader M and Stillman, Zachary and Attia, Lucas and Decker,
Gerald E and Bloch, Eric D and Fromen, Catherine A",
abstract = "Developing novel drug carriers for pulmonary delivery is
necessary to achieve higher efficacy and consistency for treating
pulmonary diseases while limiting off-target side effects that
occur from alternative routes of administration. Metal-organic
frameworks (MOFs) have recently emerged as a class of materials
with characteristics well-suited for pulmonary drug delivery,
with chemical tunability, high surface area, and pore size, which
will allow for efficient loading of therapeutic cargo and deep
lung penetration. UiO-66, a zirconium and terephthalic acid-based
MOF, has displayed notable chemical and physical stability and
journal = "ACS Appl. Mater. Interfaces",
volume = 12,
number = 35,
pages = "38989--39004",
abstract = "Developing novel drug carriers for pulmonary delivery is necessary
to achieve higher efficacy and consistency for treating pulmonary
diseases while limiting off-target side effects that occur from
alternative routes of administration. Metal-organic frameworks
(MOFs) have recently emerged as a class of materials with
characteristics well-suited for pulmonary drug delivery, with
chemical tunability, high surface area, and pore size, which will
allow for efficient loading of therapeutic cargo and deep lung
penetration. UiO-66, a zirconium and terephthalic acid-based MOF,
has displayed notable chemical and physical stability and
potential biocompatibility; however, its feasibility for use as a
pulmonary drug delivery vehicle has yet to be examined. Here, we
evaluate the use of UiO-66 nanoparticles (NPs) as novel pulmonary
Expand All @@ -140,40 +135,37 @@ @ARTICLE{Jarai2020-tn
cargo, cargo release, biocompatibility, or biodistribution. This
is a critical result, as it indicates the robust consistency of
UiO-66, a critical feature for pulmonary drug delivery, which is
plagued by inconsistent dosage because of variable properties.
Not only that, but UiO-66 NPs also demonstrate pH-dependent
stability, with resistance to degradation in extracellular
conditions and breakdown in intracellular environments.
Furthermore, the carriers exhibit high biocompatibility and low
cytotoxicity in vitro and are well-tolerated in in vivo murine
evaluations of orotracheally administered NPs. Following
pulmonary delivery, UiO-66 NPs remain localized to the lungs
before clearance over the course of seven days. Our results
demonstrate the feasibility of using UiO-66 NPs as a novel
platform for pulmonary drug delivery through their tunable NP
properties, which allow for controlled aerodynamics and
plagued by inconsistent dosage because of variable properties. Not
only that, but UiO-66 NPs also demonstrate pH-dependent stability,
with resistance to degradation in extracellular conditions and
breakdown in intracellular environments. Furthermore, the carriers
exhibit high biocompatibility and low cytotoxicity in vitro and
are well-tolerated in in vivo murine evaluations of orotracheally
administered NPs. Following pulmonary delivery, UiO-66 NPs remain
localized to the lungs before clearance over the course of seven
days. Our results demonstrate the feasibility of using UiO-66 NPs
as a novel platform for pulmonary drug delivery through their
tunable NP properties, which allow for controlled aerodynamics and
internalization-dependent cargo release while displaying
remarkable pulmonary biocompatibility.",
journal = "ACS Appl. Mater. Interfaces",
volume = 12,
number = 35,
pages = "38989--39004",
month = sep,
year = 2020,
keywords = "UiO-66; aerosols; defectiveness; metal−organic frameworks;
nanoparticles; pulmonary drug delivery;Website",
language = "en",
pdf = {Evaluating UiO-66 Metal−Organic Framework Nanoparticles as Acid-Sensitive Carriers.pdf},
preview = {appliedmaterials.gif}
nanoparticles; pulmonary drug delivery",
language = "en"
}

@ARTICLE{Decker2019-kv,
title = "Controlling Size, Defectiveness, and Fluorescence in Nanoparticle
{UiO-66} Through Water and Ligand Modulation",
{UiO}-66 Through Water and Ligand Modulation",
author = "Decker, Gerald E and Stillman, Zachary and Attia, Lucas and
Fromen, Catherine A and Bloch, Eric D",
abstract = "UiO-66, a zirconium(IV) metal-organic framework (MOF) comprised
of six-metal clusters and terephthalic acid ligands, displays
journal = "Chem. Mater.",
volume = 31,
number = 13,
pages = "4831--4839",
abstract = "UiO-66, a zirconium(IV) metal-organic framework (MOF) comprised of
six-metal clusters and terephthalic acid ligands, displays
excellent thermal and chemical stability and has functions in gas
storage, catalysis, selective adsorption, and drug delivery.
Though the stability of UiO-66 is highly advantageous,
Expand All @@ -188,75 +180,15 @@ @ARTICLE{Decker2019-kv
120 nm, while maintaining high crystallinity in the nanoparticles
that were formed. We also find that particle defectiveness is
linked to common over-estimation of particle size measurements
obtained via dynamic light scattering (DLS) and propose a model
to correct elevated hydrodynamic diameter measurements. Finally,
we report inherent fluorescence of non-functionalized UiO-66,
which exhibits peak fluorescence at a wavelength of 390 nm
following excitation at 280 nm and is maximized in large,
defect-free particles. Overall, this synthetic approach and
characterization of defect, size, and fluorescence represent new
opportunities to tune the physiochemical properties of UiO-66.",
journal = "Chem. Mater.",
volume = 31,
number = 13,
pages = "4831--4839",
obtained via dynamic light scattering (DLS) and propose a model to
correct elevated hydrodynamic diameter measurements. Finally, we
report inherent fluorescence of non-functionalized UiO-66, which
exhibits peak fluorescence at a wavelength of 390 nm following
excitation at 280 nm and is maximized in large, defect-free
particles. Overall, this synthetic approach and characterization
of defect, size, and fluorescence represent new opportunities to
tune the physiochemical properties of UiO-66.",
month = jul,
year = 2019,
keywords = "Website",
language = "en",
pdf = {Controlling Size, Defectiveness, and Fluorescence in Nanoparticle UiO-66.pdf},
preview = {chemmat.gif}
}


@ARTICLE{Attia2024-qn,
title = "{Surfactant-Polymer} Complexation and Competition on Drug
Nanocrystal Surfaces Control Crystallinity",
author = "Attia, Lucas and Nguyen, Dien and Gokhale, Devashish and Zheng,
Talia and Doyle, Patrick S",
abstract = "Nanosizing drug crystals has emerged as a successful approach to
enabling oral bioavailability, as increasing drug crystal surface
area improves dissolution kinetics and effective solubility.
Recently, bottom-up methods have been developed to directly
assemble nanosized crystals by leveraging polymer and surfactant
excipients during crystallization to control crystal size,
morphology, and structure. However, while significant research
has investigated how polymers and other single additives inhibit
or promote crystallization in pharmaceutical systems, there is
little work studying the mechanistic interactions of multiple
excipients on drug crystal structure and the extent of
crystallinity, which can influence formulation performance. This
study explores how the structure and crystallinity of a model
hydrophobic drug crystal, fenofibrate, change as a result of
competitive interfacial chemisorption between common nonionic
surfactants (polysorbate 80 and sorbitan monooleate) and a
surface-active polymer excipient (methylcellulose). Classical
molecular dynamics simulations highlight how key intermolecular
interactions, including surfactant-polymer complexation and
surfactant screening of the crystal surface, modify the resulting
crystal structure. In parallel, experiments generating drug
nanocrystals in hydrogel thin films validate that drug
crystallinity increases with an increasing weight fraction of
surfactant. Simulation results reveal a connection between
accelerated dynamics in the bulk crystal and the experimentally
measured extent of crystallinity. To our knowledge, these are the
first simulations that directly characterize structural changes
in a drug crystal as a result of excipient surface composition
and relate the experimental extent of crystallinity to structural
changes in the molecular crystal. Our approach provides a
mechanistic understanding of crystallinity in
nanocrystallization, which can expand the range of orally
deliverable small molecule therapies.",
journal = "ACS Appl. Mater. Interfaces",
volume = 16,
number = 26,
pages = "34409--34418",
month = jul,
year = 2024,
keywords = "crystallinity; interfaces; molecular dynamics; nanoformulations;
polymers; surfactants",
language = "en",
pdf = {attia-et-al-2024-surfactant-polymer-complexation-and-competition-on-drug-nanocrystal-surfaces-control-crystallinity.pdf},
preview = {TOC_ami.png}
language = "en"
}

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