Cone Adaptation
This document describe current model for the outer segment membrane currents of primate cones.
The model can be mathematically characterized by a set of differential equations.
The detailed explanation for each equation and the default values for the parameters can be found here.
In ISETBIO, the main entry for this physiological differential equation based cone adaptation model is riekeAdapt. It depends on three important functions: riekeInit, riekeAdaptSteadyState and riekeAdaptTemporal.
riekeInit set up default values for all parameters used in the differential equations. riekeAdaptSteadyState computes response for a steady inputs stimulus. This function returns all intermediate state (PDE, cGMP, etc.) together with the adapted outer segment membrane currents. riekeAdaptTemporal computes the temporal response for a time varying stimulus by iteratively updates the discretized differential equations (numerical solution).
An analytic report for script from Fred Rieke can be found here. The comparison between ISETBIO implementations and Rieke's original script can be found here. The disagreement is because derived formula is a little different for current computation. We will resolve this issue by discussing with Fred and compare the results with some real data.
In ISETBIO, there are some other simpler cone adaptation model implemented in coneAdapt. Most of them are just for steady state response and we should compare and see how different they are.