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Achievement: Pair ExtraordinaireAchievement: Pull Shark

Achievements

Achievement: Pair ExtraordinaireAchievement: Pull Shark

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@ErillLab

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eliamascolo/README.md

Hi there 👋

I do research as a PhD student in the Erill Lab, where I study the evolution of gene regulatory networks.

Current research projects:

  • I'm developing computational methods to detect transcriptional cross-regulation between chromosomal genes and mobile genetic elements → MGE-TF project.

  • We are also developing new models of transcriptional regulation that can capture the role of variable spacers in DNA binding motifs (due to flexible components), as well as DNA shape features. The software we are developing can learn complex DNA patterns from biological data (promoters of known target genes) using an evolutionary algorithm → MDGP project

Completed research projects

  • We have shown that some viruses evolve host-MGE cross-regulations to hack the gene network of the host they infect and synchronize lysis with the host life cycle (Mascolo et al. 2022), via computational prediction and experimental validation → LPEG phages project

  • We discovered the first known case of a virus that attaches to another virus (paper) by combining microscopy and bioinformatics → SPA project

Find me elsewhere

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  1. ErillLab/LPEG_phages ErillLab/LPEG_phages Public

    Code and data for the analysis of TF-binding sites positional entropy in phage genomes, used in Mascolo et al. (2022)

    Python 1

  2. ErillLab/FLEMINGO ErillLab/FLEMINGO Public

    A project to generate models of regulated bacterial promoters using genetic programming

    Python 1

  3. ErillLab/SPA ErillLab/SPA Public

    Code and data used to perform the tAI analysis in deCarvalho et al. (2023)

    Scheme 1