Merge pull request #408 from edmcouncil/IDMP-420

IDMP-420 - Update Terlipressin Example for reference strength
edmcouncil · Jul 7, 2023 · 091a9cf · 091a9cf
2 parents 81fea77 + 80498c8
commit 091a9cf
Show file tree

Hide file tree

Showing 7 changed files with 134 additions and 56,108 deletions.
diff --git a/EXT/Examples/AmlodipineExample.rdf b/EXT/Examples/AmlodipineExample.rdf
@@ -162,20 +162,32 @@
 
 	<owl:NamedIndividual rdf:about="&idmp-amp;AmlodipineAsReferenceStrengthInAmlodipineEMCStrength">
 		<rdf:type rdf:resource="&idmp-mprd;MassBasedStrength"/>
+		<rdf:type rdf:resource="&idmp-mprd;PresentationStrength"/>
+		<rdf:type rdf:resource="&idmp-mprd;ReferenceStrength"/>
 		<rdfs:label>amlodipine as reference strength in Amlodipine EMC strength</rdfs:label>
+		<idmp-mprd:hasReferenceIngredientRole rdf:resource="&idmp-amp;AmlodipineAsReferenceSubstance"/>
 		<idmp-mprd:hasReferenceSubstance rdf:resource="&idmp-amp;Amlodipine"/>
 		<cmns-qtu:hasDenominator rdf:resource="&idmp-amp;AmlodipineDenominatorInAmlodipineEMCPresentationStrength"/>
 		<cmns-qtu:hasNumerator rdf:resource="&idmp-amp;AmlodipineNumeratorInAmlodipineEMCPresentationStrength"/>
 	</owl:NamedIndividual>
 
 	<owl:NamedIndividual rdf:about="&idmp-amp;AmlodipineAsReferenceStrengthInNorvascPresentationStrength">
 		<rdf:type rdf:resource="&idmp-mprd;MassBasedStrength"/>
+		<rdf:type rdf:resource="&idmp-mprd;PresentationStrength"/>
+		<rdf:type rdf:resource="&idmp-mprd;ReferenceStrength"/>
 		<rdfs:label>amlodipine as reference strength in Norvasc presentation strength</rdfs:label>
+		<idmp-mprd:hasReferenceIngredientRole rdf:resource="&idmp-amp;AmlodipineAsReferenceSubstance"/>
 		<idmp-mprd:hasReferenceSubstance rdf:resource="&idmp-amp;Amlodipine"/>
 		<cmns-qtu:hasDenominator rdf:resource="&idmp-amp;AmlodipineDenominatorInNorvascPresentationStrength"/>
 		<cmns-qtu:hasNumerator rdf:resource="&idmp-amp;AmlodipineNumeratorInNorvascPresentationStrength"/>
 	</owl:NamedIndividual>
 
+	<owl:NamedIndividual rdf:about="&idmp-amp;AmlodipineAsReferenceSubstance">
+		<rdf:type rdf:resource="&idmp-mprd;ActiveIngredientActiveMoietyBasisOfStrength"/>
+		<rdfs:label>amlodipine as reference substance</rdfs:label>
+		<cmns-pts:isPlayedBy rdf:resource="&idmp-amp;Amlodipine"/>
+	</owl:NamedIndividual>
+
 	<owl:NamedIndividual rdf:about="&idmp-amp;AmlodipineBesylate">
 		<rdf:type rdf:resource="&idmp-sub;ChemicalSubstance"/>
 		<rdf:type rdf:resource="&idmp-sub;Salt"/>

diff --git a/EXT/Examples/TerlipressinExample.rdf b/EXT/Examples/TerlipressinExample.rdf
@@ -290,6 +290,7 @@
 
 	<owl:NamedIndividual rdf:about="&idmp-trlp;TerlipressinAcetatePresentationStrengthInTerlipressinAcetateSUN1MgPerAmpouleSolutionForInjection">
 		<rdf:type rdf:resource="&idmp-mprd;MassBasedStrength"/>
+		<rdf:type rdf:resource="&idmp-mprd;PresentationStrength"/>
 		<rdfs:label>terlipressin acetate presentation strength in terlipressin SUN 1 mg per ampoule solution for injection</rdfs:label>
 		<idmp-mprd:hasReferenceSubstance rdf:resource="&idmp-trlp;TerlipressinAcetate"/>
 		<cmns-qtu:hasDenominator rdf:resource="&idmp-trlp;TerlipressinAcetateDenominatorInTerlipressinSUN1MgSolutionForInjectionPresentationStrength"/>
@@ -330,7 +331,7 @@
 	<owl:NamedIndividual rdf:about="&idmp-trlp;TerlipressinAcetateSUN0.12MgPerMlSolutionForInjectionComposition">
 		<rdf:type rdf:resource="&idmp-mprd;ProductComposition"/>
 		<rdfs:label>terlipressin acetate SUN 0.12 mg/ml solution for injection composition</rdfs:label>
-		<idmp-sub:hasIngredient rdf:resource="&idmp-trlp;TerlipressinAsReferenceStrengthInTerlipressinAcetate1MgPerAmpouleSolutionForInjection"/>
+		<idmp-mprd:hasActiveIngredient rdf:resource="&idmp-trlp;TerlipressinAcetateStrengthAsManufacturedInTerlipressinAcetate1MgPerAmpouleSolutionForInjection"/>
 		<cmns-dsg:defines rdf:resource="&idmp-trlp;TerlipressinAcetateSUN0.12MgPerMlSolutionForInjection"/>
 		<cmns-rga:isApplicableInJurisdiction rdf:resource="&lcc-3166-1;UnitedKingdomOfGreatBritainAndNorthernIreland"/>
 	</owl:NamedIndividual>
@@ -370,7 +371,19 @@
 		<idmp-mprd:hasStrength rdf:resource="&idmp-trlp;TerlipressinAcetateConcentrationStrengthInTerlipressinAcetate1MgPerAmpouleSolutionForInjection"/>
 		<idmp-mprd:hasStrength rdf:resource="&idmp-trlp;TerlipressinAcetatePresentationStrengthInTerlipressinAcetateSUN1MgPerAmpouleSolutionForInjection"/>
 		<cmns-pts:isPlayedBy rdf:resource="&idmp-trlp;TerlipressinAcetate"/>
-		<cmns-pts:isRealizedIn rdf:resource="&idmp-trlp;TerlipressinAcetateSUNComposition"/>
+		<cmns-pts:isRealizedIn rdf:resource="&idmp-trlp;TerlipressinAcetateSUN0.12MgPerMlSolutionForInjectionComposition"/>
+	</owl:NamedIndividual>
+
+	<owl:NamedIndividual rdf:about="&idmp-trlp;TerlipressinAsActiveIngredientInTerlipressinAcetate1MgPerAmpouleSolutionForInjection">
+		<rdf:type rdf:resource="&idmp-mprd;ActiveIngredientActiveMoietyBasisOfStrength"/>
+		<rdfs:label>terlipressin as active ingredient in terlipressin acetate 1 mg per ampoule solution for injection</rdfs:label>
+		<skos:definition>terlipressin in the role of an active moiety that provides the reference strength in terlipressin acetate 1 mg per ampoule solution for injection</skos:definition>
+		<idmp-mprd:hasReferenceStrength rdf:resource="&idmp-trlp;TerlipressinAsReferenceConcentrationStrengthInTerlipressinAcetate1MgPerMlSolutionForInjection"/>
+		<idmp-mprd:hasReferenceStrength rdf:resource="&idmp-trlp;TerlipressinAsReferencePresentationStrengthInTerlipressinAcetate1MgPerMlSolutionForInjection"/>
+		<cmns-pts:isPlayedBy rdf:resource="&idmp-trlp;Terlipressin"/>
+		<cmns-pts:isRealizedIn rdf:resource="&idmp-trlp;TerlipressinAcetateSUN0.12MgPerMlSolutionForInjectionComposition"/>
+		<cmns-pts:isRealizedIn rdf:resource="&idmp-trlp;TerlipressinSUN0.1MgPerMlSolutionForInjectionComposition"/>
+		<cmns-pts:isRealizedIn rdf:resource="&idmp-trlp;TerlipressinSUN1MgSolutionForInjectionComposition"/>
 	</owl:NamedIndividual>
 
 	<owl:NamedIndividual rdf:about="&idmp-trlp;TerlipressinAsActiveMoiety">
@@ -385,6 +398,7 @@
 	<owl:NamedIndividual rdf:about="&idmp-trlp;TerlipressinAsReferenceConcentrationStrengthInTerlipressinAcetate1MgPerMlSolutionForInjection">
 		<rdf:type rdf:resource="&idmp-mprd;Concentration"/>
 		<rdf:type rdf:resource="&idmp-mprd;MassBasedStrength"/>
+		<rdf:type rdf:resource="&idmp-mprd;ReferenceStrength"/>
 		<rdfs:label>terlipressin as reference (concentration) strength in terlipressin acetate 1 mg/ml solution for injection</rdfs:label>
 		<idmp-mprd:hasReferenceSubstance rdf:resource="&idmp-trlp;Terlipressin"/>
 		<cmns-qtu:hasDenominator rdf:resource="&idmp-trlp;TerlipressinDenominatorInTerlipressinAcetate1MgPerMlSolutionForInjectionConcentrationStrength"/>
@@ -393,24 +407,14 @@
 
 	<owl:NamedIndividual rdf:about="&idmp-trlp;TerlipressinAsReferencePresentationStrengthInTerlipressinAcetate1MgPerMlSolutionForInjection">
 		<rdf:type rdf:resource="&idmp-mprd;MassBasedStrength"/>
+		<rdf:type rdf:resource="&idmp-mprd;PresentationStrength"/>
+		<rdf:type rdf:resource="&idmp-mprd;ReferenceStrength"/>
 		<rdfs:label>terlipressin as reference (presentation) strength in terlipressin acetate 1 mg/ml solution for injection</rdfs:label>
 		<idmp-mprd:hasReferenceSubstance rdf:resource="&idmp-trlp;Terlipressin"/>
 		<cmns-qtu:hasDenominator rdf:resource="&idmp-trlp;TerlipressinDenominatorInTerlipressinAcetate1MgPerMlSolutionForInjectionPresentationStrength"/>
 		<cmns-qtu:hasNumerator rdf:resource="&idmp-trlp;TerlipressinNumeratorInTerlipressinAcetate1MgPerMlSolutionForInjectionPresentationStrength"/>
 	</owl:NamedIndividual>
 
-	<owl:NamedIndividual rdf:about="&idmp-trlp;TerlipressinAsReferenceStrengthInTerlipressinAcetate1MgPerAmpouleSolutionForInjection">
-		<rdf:type rdf:resource="&idmp-mprd;ActiveIngredientActiveMoietyBasisOfStrength"/>
-		<rdfs:label>terlipressin as reference strength in terlipressin acetate 1 mg per ampoule solution for injection</rdfs:label>
-		<skos:definition>terlipressin in the role of an active moiety that provides the reference strength in terlipressin acetate 1 mg per ampoule solution for injection</skos:definition>
-		<idmp-mprd:hasReferenceStrength rdf:resource="&idmp-trlp;TerlipressinAsReferenceConcentrationStrengthInTerlipressinAcetate1MgPerMlSolutionForInjection"/>
-		<idmp-mprd:hasReferenceStrength rdf:resource="&idmp-trlp;TerlipressinAsReferencePresentationStrengthInTerlipressinAcetate1MgPerMlSolutionForInjection"/>
-		<cmns-pts:isPlayedBy rdf:resource="&idmp-trlp;Terlipressin"/>
-		<cmns-pts:isRealizedIn rdf:resource="&idmp-trlp;TerlipressinAcetateSUN0.12MgPerMlSolutionForInjectionComposition"/>
-		<cmns-pts:isRealizedIn rdf:resource="&idmp-trlp;TerlipressinSUN0.1MgPerMlSolutionForInjectionComposition"/>
-		<cmns-pts:isRealizedIn rdf:resource="&idmp-trlp;TerlipressinSUN1MgSolutionForInjectionComposition"/>
-	</owl:NamedIndividual>
-
 	<owl:NamedIndividual rdf:about="&idmp-trlp;TerlipressinCommonName">
 		<rdf:type rdf:resource="&idmp-ra;InternationalNonproprietaryName"/>
 		<rdfs:label>terlipressin common name</rdfs:label>
@@ -512,8 +516,7 @@
 	<owl:NamedIndividual rdf:about="&idmp-trlp;TerlipressinSUN0.1MgPerMlSolutionForInjectionComposition">
 		<rdf:type rdf:resource="&idmp-mprd;ProductComposition"/>
 		<rdfs:label>terlipressin SUN 0.1 mg/ml solution for injection composition</rdfs:label>
-		<idmp-sub:hasIngredient rdf:resource="&idmp-trlp;TerlipressinAsReferenceStrengthInTerlipressinAcetate1MgPerAmpouleSolutionForInjection"/>
-		<idmp-mprd:hasReferenceSubstance rdf:resource="&idmp-trlp;Terlipressin"/>
+		<idmp-mprd:hasActiveIngredient rdf:resource="&idmp-trlp;TerlipressinAsActiveIngredientInTerlipressinAcetate1MgPerAmpouleSolutionForInjection"/>
 		<cmns-dsg:defines rdf:resource="&idmp-trlp;TerlipressinSUN0.1MgPerMlSolutionForInjection"/>
 		<cmns-rga:isApplicableInJurisdiction rdf:resource="&lcc-3166-1;Netherlands"/>
 	</owl:NamedIndividual>
@@ -544,7 +547,7 @@
 	<owl:NamedIndividual rdf:about="&idmp-trlp;TerlipressinSUN1MgSolutionForInjectionComposition">
 		<rdf:type rdf:resource="&idmp-mprd;ProductComposition"/>
 		<rdfs:label>terlipressin SUN 1 mg solution for injection composition</rdfs:label>
-		<idmp-sub:hasIngredient rdf:resource="&idmp-trlp;TerlipressinAsReferenceStrengthInTerlipressinAcetate1MgPerAmpouleSolutionForInjection"/>
+		<idmp-mprd:hasActiveIngredient rdf:resource="&idmp-trlp;TerlipressinAsActiveIngredientInTerlipressinAcetate1MgPerAmpouleSolutionForInjection"/>
 		<cmns-dsg:defines rdf:resource="&idmp-trlp;TerlipressinSUN1MgSolutionForInjection"/>
 		<cmns-rga:isApplicableInJurisdiction rdf:resource="&lcc-3166-1;Sweden"/>
 	</owl:NamedIndividual>

diff --git a/etc/CQ/Example/uc1_cq3-1.sparql b/etc/CQ/Example/uc1_cq3-1.sparql
@@ -23,7 +23,7 @@ WHERE {
 
   	# Bind Variable Product <$Product>
 	# Example for AMPLODIPINE: <https://spec.pistoiaalliance.org/idmp/ontology/EXT/Examples/AmlodipineExample/Norvasc-ManufacturedItem>
-  	# Example for Terlipressin: <https://spec.pistoiaalliance.org/idmp/ontology/EXT/Examples/TerlipressinExample/TerlipressinAcetateSUN>
+  	# Example for Terlipressin: <https://spec.pistoiaalliance.org/idmp/ontology/EXT/Examples/TerlipressinExample/TerlipressinAcetateSUN-PharmaceuticalProduct>
     BIND(uc1_cq3-1_parameter_2 AS $Product )
 
   	# Get $Product's active ingredient that is played by $Substace that has a Basis Of Strength

diff --git a/etc/CQ/Example/uc1_cq3.sparql b/etc/CQ/Example/uc1_cq3.sparql
@@ -15,18 +15,19 @@ WHERE {
     BIND(uc1_cq3_parameter_1 AS $ActiveMoiety )
 
   	# Get Substances with active moiety $ActiveMoiety
-  	{
-    	# Use the shortcut (isActiveMoietyOf or hasActiveMoiety)
-    	?Substance ^idmp-sub:isActiveMoietyOf|idmp-sub:hasActiveMoiety $ActiveMoiety .
-  	} UNION {
-    	# Use the $ActiveMoiety in a role for composition that defines a substance.
-    	[] cmns-dsg:defines ?Substance ;
-      	 	cmns-pts:hasRole [
-      			a idmp-sub:ActiveMoietyRole ;
-    			cmns-pts:isPlayedBy $ActiveMoiety
-    	] .
-  	}
-
+        {
+        # Use the shortcut (isActiveMoietyOf or hasActiveMoiety)
+        ?Substance ^idmp-sub:isActiveMoietyOf|idmp-sub:hasActiveMoiety $ActiveMoiety .
+        } UNION {
+        # Use the $ActiveMoiety in a role for composition that defines a substance.
+        [] cmns-dsg:defines ?Substance ;
+                cmns-pts:hasRole [
+                       a idmp-sub:ActiveMoietyRole ;
+                       cmns-pts:isPlayedBy $ActiveMoiety
+        ] .
+        } UNION {
+    BIND($ActiveMoiety AS ?Substance)
+    }
 
     # Make sure that we only return actual substances
     ?Substance a/rdfs:subClassOf* idmp-sub:Substance .