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gnomaf

n + k annotations

The script 5combo.py provides code to combine dataset allele specific annotations in an n+k manner

The process:

  1. Merge gVCFS into one VDS
  2. Convert a VDS into an AS annotation table (using Lindo's scripts to fill in missing annotations for each dataset)
  3. Combine AS tables using the n + k combination code --> note: the RankSum combination is not currently exact, would need to do an update to the code with the new histogram CDF in hail

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