This package has two functions: Network and MaPR.
The Network function with parameter NetworkType of 'ProteinSpecific' constructs a post-transcriptional regulatory network by simultaneously analyzing transcriptomic data and proteomic data of the same cohort.
The MaPR function predicts master protein abundance regulators based on the permutation of the post-transcriptional regulatory network generated by the Network function.
The package can be installed directly from GitHub by typing the following in an R console:
if(!require("devtools")) install.packages("devtools")
devtools::install_github("https://github.com/Huang-lab/MaPR")
library(MaPR)If you used or adapted MaPR in your study, please cite our paper [Under submission].
If you run into issues, you can contact authors: zishan.wang{at}mssm.edu or kuan-lin.huang{at}mssm.edu.