This bundle of code and data can be downloaded using the button on the top right, either through git at the command line, or as a zip (which then needs to be extracted).
This tutorial uses R and Bioconductor. If you don't have R installed, or you've never used it before, help is available here. I would recommend using Rstudio to run this tutorial. More information about Bioconductor is available on their website.
First, you should install all of the packages in the 'dependencies.R' file. This requires you to install the Bioconductor package manager if you don't have it already, there is a line you can uncomment to do this. This might take a bit of time on a fresh R install, as R packages tend to bring in a lot of heavy dependencies.
You should now be able to open the notebook.Rmd file in Rstudio and run it
through without any problems. You should have my email address if anything
does go wrong.