CHORUS-TRE is a secure Trusted Research Environment developed by the BDSC, NeuroDigital and DSI teams of the University Hospital of Lausanne, Switzerland.

CHORUS-TRE is revolutionizing biomedical research by addressing critical pain points such as data fragmentation, lack of collaboration, and compliance challenges. This innovative platform facilitates secure data sharing and collaboration, ensuring adherence to an increasingly stringent regulatory framework. At its core, the TRE provides secure access to researchers through rigorous vetting, employs privacy protection measures like risk-based anonymization, synthetic data generation, remote query execution with differential privacy, and enforces controlled usage with strict data handling protocols. This environment is designed for scalability, capable of processing next-gen sequencing, imaging data, and electronic health records efficiently.

CHORUS-TRE emphasizes privacy-enhancing technologies, security, user-centric design, and community engagement. These core principles ensure that the platform not only protects user data but also aligns with user needs and fosters trust within the research community.

The impact of the TRE is profound, and will be offering a foundation for precision medicine through AI, enabling advanced multimodal data studies, attracting external funding, and fostering innovation through collaborations with startups. The SCRUM approach ensures iterative development, prioritizing user feedback for continuous improvement. This project, supported by the Directorate for Innovation and Clinical Research, the IT Department, the Lundin Family Brain Tumor Research Center, and the Department of Clinical Neuroscience, represents a significant leap forward in creating a trusted, collaborative research ecosystem.

CHORUS-TRE V2 is a work in progress and is actively being developed.

Follow this guide to deploy a CHORUS-TRE V2 instance.

CHORUS-TRE V1 is based on the Human Intracerebral EEG Platform (HIP), an open-source platform designed for collecting, managing, analyzing, and sharing data at an international level. Its primary mission is to promote the development of large-scale research projects by facilitating international collaborations.

This project was supported by the EBRAINS research infrastructure, funded by the European Union’s Horizon 2020 Framework Programme for Research and Innovation under the Specific Grant Agreement No. 945539 (Human Brain Project SGA3). https://www.ebrains.eu/tools/human-intracerebral-eeg-platform

Follow this guide to install a CHORUS-TRE V1 instance the regular way.

Follow this guide to deploy a fully dockerized (DinD) CHORUS-TRE V1 instance.

• User documentation https://hip-infrastructure.github.io
• Architecture https://github.com/HIP-infrastructure/hip-doc/blob/master/Architecture.md
• C4 architecture https://github.com/HIP-infrastructure/hip-doc?tab=readme-ov-file

Check out our demo instance to find out the possibilities of the CHORUS-TRE V1 platform.

Any use of the software for purposes other than academic research, including for commercial purposes, shall be requested in advance from CHUV.