diff --git a/substratevm/mx.substratevm/suite.py b/substratevm/mx.substratevm/suite.py
index f1fd53da29c35..2655fea01f85f 100644
--- a/substratevm/mx.substratevm/suite.py
+++ b/substratevm/mx.substratevm/suite.py
@@ -308,6 +308,9 @@
                     "jdk.internal.util",
                     "jdk.internal.org.objectweb.asm",
                 ],
+                "java.instrument":[
+                    "java.lang.instrument"
+                ],
                 "java.management": [
                     "com.sun.jmx.mbeanserver",
                     "sun.management",
@@ -639,6 +642,9 @@
                     "sun.util.locale",
                     "sun.invoke.util",
                 ],
+                "java.instrument":[
+                    "java.lang.instrument"
+                ],
                 "java.management": [
                     "com.sun.jmx.mbeanserver", # Needed for javadoc links (MXBeanIntrospector,DefaultMXBeanMappingFactory, MXBeanProxy)
                     "sun.management", # Needed for javadoc links (MappedMXBeanType)
diff --git a/substratevm/src/com.oracle.svm.core/src/com/oracle/svm/core/JavaMainWrapper.java b/substratevm/src/com.oracle.svm.core/src/com/oracle/svm/core/JavaMainWrapper.java
index 57d0bb30441e8..f1ad4c4bc2054 100644
--- a/substratevm/src/com.oracle.svm.core/src/com/oracle/svm/core/JavaMainWrapper.java
+++ b/substratevm/src/com.oracle.svm.core/src/com/oracle/svm/core/JavaMainWrapper.java
@@ -166,19 +166,22 @@ public List<String> getInputArguments() {
     }
 
     public static void invokeMain(String[] args) throws Throwable {
+        PreMainSupport preMainSupport = ImageSingletons.lookup(PreMainSupport.class);
+        String[] mainArgs = preMainSupport.retrievePremainArgs(args);
+        preMainSupport.invokePremain();
         JavaMainSupport javaMainSupport = ImageSingletons.lookup(JavaMainSupport.class);
         if (javaMainSupport.mainNonstatic) {
             Object instance = javaMainSupport.javaMainClassCtorHandle.invoke();
             if (javaMainSupport.mainWithoutArgs) {
                 javaMainSupport.javaMainHandle.invoke(instance);
             } else {
-                javaMainSupport.javaMainHandle.invoke(instance, args);
+                javaMainSupport.javaMainHandle.invoke(instance, mainArgs);
             }
         } else {
             if (javaMainSupport.mainWithoutArgs) {
                 javaMainSupport.javaMainHandle.invokeExact();
             } else {
-                javaMainSupport.javaMainHandle.invokeExact(args);
+                javaMainSupport.javaMainHandle.invokeExact(mainArgs);
             }
         }
     }
diff --git a/substratevm/src/com.oracle.svm.core/src/com/oracle/svm/core/PreMainSupport.java b/substratevm/src/com.oracle.svm.core/src/com/oracle/svm/core/PreMainSupport.java
new file mode 100644
index 0000000000000..24378dbe27666
--- /dev/null
+++ b/substratevm/src/com.oracle.svm.core/src/com/oracle/svm/core/PreMainSupport.java
@@ -0,0 +1,234 @@
+/*
+ * Copyright (c) 2024, 2024, Oracle and/or its affiliates. All rights reserved.
+ * Copyright (c) 2024, 2024, Alibaba Group Holding Limited. All rights reserved.
+ * DO NOT ALTER OR REMOVE COPYRIGHT NOTICES OR THIS FILE HEADER.
+ *
+ * This code is free software; you can redistribute it and/or modify it
+ * under the terms of the GNU General Public License version 2 only, as
+ * published by the Free Software Foundation.  Oracle designates this
+ * particular file as subject to the "Classpath" exception as provided
+ * by Oracle in the LICENSE file that accompanied this code.
+ *
+ * This code is distributed in the hope that it will be useful, but WITHOUT
+ * ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or
+ * FITNESS FOR A PARTICULAR PURPOSE.  See the GNU General Public License
+ * version 2 for more details (a copy is included in the LICENSE file that
+ * accompanied this code).
+ *
+ * You should have received a copy of the GNU General Public License version
+ * 2 along with this work; if not, write to the Free Software Foundation,
+ * Inc., 51 Franklin St, Fifth Floor, Boston, MA 02110-1301 USA.
+ *
+ * Please contact Oracle, 500 Oracle Parkway, Redwood Shores, CA 94065 USA
+ * or visit www.oracle.com if you need additional information or have any
+ * questions.
+ */
+
+package com.oracle.svm.core;
+
+import com.oracle.svm.core.util.VMError;
+import org.graalvm.nativeimage.Platform;
+import org.graalvm.nativeimage.Platforms;
+
+import java.lang.instrument.ClassDefinition;
+import java.lang.instrument.ClassFileTransformer;
+import java.lang.instrument.Instrumentation;
+import java.lang.instrument.UnmodifiableClassException;
+import java.lang.reflect.Method;
+import java.util.ArrayList;
+import java.util.HashMap;
+import java.util.List;
+import java.util.Map;
+import java.util.Set;
+import java.util.jar.JarFile;
+
+/**
+ * Java agent can do instrumentation initialization work in premain phase. This class supports
+ * registering such premain methods at native image build time and invoking them at native image
+ * runtime. <br>
+ * JVM supports two kind of premain methods:
+ * <ol>
+ * <li>{@code public static void premain(String agentArgs, Instrumentation inst)}</li>
+ * <li>{@code public static void premain(String agentArgs)}</li>
+ * </ol>
+ * For the first one, at registration time we will set the second parameter with an instance of
+ * {@link SVMRuntimeInstrumentImpl} class which does not do any actual work as no instrumentation
+ * can do in native code at runtime.
+ * <p>
+ * <b>Be noticed</b>, the original agent premain method may not work well at native image runtime
+ * even if the input {@link Instrumentation} class is replaced with
+ * {@link SVMRuntimeInstrumentImpl}.
+ * </p>
+ * <p>
+ * It is the agent developers' responsibility to implement a native version of their agent premain
+ * method. It can be implemented in two ways:
+ * <ul>
+ * <li>Isolate code by checking current runtime. For example: <code>
+ *         <pre>
+ *         String vm = System.getProperty("java.vm.name");
+ *         if ("Substrate VM".equals(vm)) {
+ *           // native image runtime
+ *         } else{
+ *           // JVM runtime
+ *         }
+ *         </pre>
+ *     </code></li>
+ * <li>Use {@link com.oracle.svm.core.annotate.TargetClass} API to implement a native image version
+ * premain.</li>
+ * </ul>
+ * </p>
+ */
+public class PreMainSupport {
+
+    private static final String PREMAIN_OPTION_PREFIX = "-XX-premain:";
+
+    class PremainMethod {
+        String className;  // full qualified premain class name
+        Method method;
+        Object[] args;
+
+        PremainMethod(String className, Method method, Object[] args) {
+            this.className = className;
+            this.method = method;
+            this.args = args;
+        }
+    }
+
+    private Map<String, String> premainOptions = new HashMap<>();
+    // Order matters
+    private List<PremainMethod> premainMethods = new ArrayList<>();
+
+    @Platforms({Platform.HOSTED_ONLY.class})
+    public void registerPremainMethod(String className, Method executable, Object... args) {
+        premainMethods.add(new PremainMethod(className, executable, args));
+    }
+
+    /**
+     * Retrieve premain options from input args.
+     * Keep premain options and return the rest args as main args.
+     * The premain options format:
+     * <br>
+     * -XX-premain:[full.qualified.premain.class]:[premain options]
+     * <br>
+     *
+     * @param args
+     * @return
+     */
+    public String[] retrievePremainArgs(String[] args) {
+        List<String> mainArgs = new ArrayList<>();
+
+        for (String arg : args) {
+            if (arg.startsWith(PREMAIN_OPTION_PREFIX)) {
+                String premainOptionKeyValue = arg.substring(PREMAIN_OPTION_PREFIX.length());
+                String[] pair = premainOptionKeyValue.split(":");
+                if (pair.length == 2) {
+                    premainOptions.put(pair[0], pair[1]);
+                }
+            } else {
+                mainArgs.add(arg);
+            }
+        }
+        return mainArgs.toArray(new String[0]);
+    }
+
+    public void invokePremain() {
+        for (PremainMethod premainMethod : premainMethods) {
+            try {
+                Object[] args = premainMethod.args;
+                if (premainOptions.containsKey(premainMethod.className)) {
+                    args[0] = premainOptions.get(premainMethod.className);
+                }
+                // premain method must be static
+                premainMethod.method.invoke(null, args);
+            } catch (Throwable t) {
+                VMError.shouldNotReachHere("Fail to execute " + premainMethod.className + ".premain", t);
+            }
+        }
+    }
+
+    /**
+     * This class is a dummy implementation of {@link Instrumentation} interface. It serves as the
+     * registered premain method's second parameter. At native image runtime, no actual
+     * instrumentation work can do. So all the methods here are empty.
+     */
+    public static class SVMRuntimeInstrumentImpl implements Instrumentation {
+
+        @Override
+        public void addTransformer(ClassFileTransformer transformer, boolean canRetransform) {
+        }
+
+        @Override
+        public void addTransformer(ClassFileTransformer transformer) {
+        }
+
+        @Override
+        public boolean removeTransformer(ClassFileTransformer transformer) {
+            return false;
+        }
+
+        @Override
+        public boolean isRetransformClassesSupported() {
+            return false;
+        }
+
+        @Override
+        public void retransformClasses(Class<?>... classes) throws UnmodifiableClassException {
+        }
+
+        @Override
+        public boolean isRedefineClassesSupported() {
+            return false;
+        }
+
+        @Override
+        public void redefineClasses(ClassDefinition... definitions) throws ClassNotFoundException, UnmodifiableClassException {
+        }
+
+        @Override
+        public boolean isModifiableClass(Class<?> theClass) {
+            return false;
+        }
+
+        @Override
+        public Class<?>[] getAllLoadedClasses() {
+            return new Class<?>[0];
+        }
+
+        @Override
+        public Class<?>[] getInitiatedClasses(ClassLoader loader) {
+            return new Class<?>[0];
+        }
+
+        @Override
+        public long getObjectSize(Object objectToSize) {
+            return 0;
+        }
+
+        @Override
+        public void appendToBootstrapClassLoaderSearch(JarFile jarfile) {
+        }
+
+        @Override
+        public void appendToSystemClassLoaderSearch(JarFile jarfile) {
+        }
+
+        @Override
+        public boolean isNativeMethodPrefixSupported() {
+            return false;
+        }
+
+        @Override
+        public void setNativeMethodPrefix(ClassFileTransformer transformer, String prefix) {
+        }
+
+        @Override
+        public void redefineModule(Module module, Set<Module> extraReads, Map<String, Set<Module>> extraExports, Map<String, Set<Module>> extraOpens, Set<Class<?>> extraUses,
+                                   Map<Class<?>, List<Class<?>>> extraProvides) {
+        }
+
+        @Override
+        public boolean isModifiableModule(Module module) {
+            return false;
+        }
+    }
+}
diff --git a/substratevm/src/com.oracle.svm.hosted/src/com/oracle/svm/hosted/InstrumentFeature.java b/substratevm/src/com.oracle.svm.hosted/src/com/oracle/svm/hosted/InstrumentFeature.java
new file mode 100644
index 0000000000000..68f2efef44da8
--- /dev/null
+++ b/substratevm/src/com.oracle.svm.hosted/src/com/oracle/svm/hosted/InstrumentFeature.java
@@ -0,0 +1,118 @@
+/*
+ * Copyright (c) 2024, 2024, Oracle and/or its affiliates. All rights reserved.
+ * Copyright (c) 2024, 2024, Alibaba Group Holding Limited. All rights reserved.
+ * DO NOT ALTER OR REMOVE COPYRIGHT NOTICES OR THIS FILE HEADER.
+ *
+ * This code is free software; you can redistribute it and/or modify it
+ * under the terms of the GNU General Public License version 2 only, as
+ * published by the Free Software Foundation.  Oracle designates this
+ * particular file as subject to the "Classpath" exception as provided
+ * by Oracle in the LICENSE file that accompanied this code.
+ *
+ * This code is distributed in the hope that it will be useful, but WITHOUT
+ * ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or
+ * FITNESS FOR A PARTICULAR PURPOSE.  See the GNU General Public License
+ * version 2 for more details (a copy is included in the LICENSE file that
+ * accompanied this code).
+ *
+ * You should have received a copy of the GNU General Public License version
+ * 2 along with this work; if not, write to the Free Software Foundation,
+ * Inc., 51 Franklin St, Fifth Floor, Boston, MA 02110-1301 USA.
+ *
+ * Please contact Oracle, 500 Oracle Parkway, Redwood Shores, CA 94065 USA
+ * or visit www.oracle.com if you need additional information or have any
+ * questions.
+ */
+
+package com.oracle.svm.hosted;
+
+import com.oracle.svm.core.PreMainSupport;
+import com.oracle.svm.core.feature.AutomaticallyRegisteredFeature;
+import com.oracle.svm.core.feature.InternalFeature;
+import com.oracle.svm.core.option.HostedOptionKey;
+import com.oracle.svm.core.option.LocatableMultiOptionValue;
+import com.oracle.svm.core.util.VMError;
+import com.oracle.svm.hosted.reflect.ReflectionFeature;
+import jdk.graal.compiler.options.Option;
+import org.graalvm.nativeimage.ImageSingletons;
+import org.graalvm.nativeimage.hosted.Feature;
+
+import java.lang.instrument.Instrumentation;
+import java.lang.reflect.Method;
+import java.util.ArrayList;
+import java.util.List;
+
+/**
+ * This feature supports instrumentation in native image.
+ */
+@AutomaticallyRegisteredFeature
+public class InstrumentFeature implements InternalFeature {
+    private ClassLoader cl;
+    private PreMainSupport preMainSupport;
+
+    public static class Options {
+        @Option(help = "Specify premain-class list. Multiple classes are separated by comma, and order matters.")//
+        public static final HostedOptionKey<LocatableMultiOptionValue.Strings> PremainClasses = new HostedOptionKey<>(null);
+
+    }
+
+    /**
+     * {@link ReflectionFeature} must come before this feature, because many instrumentation methods
+     * are called by reflection, e.g. premain.
+     */
+    @Override
+    public List<Class<? extends Feature>> getRequiredFeatures() {
+        return List.of(ReflectionFeature.class);
+    }
+
+    @Override
+    public void afterRegistration(AfterRegistrationAccess access) {
+        FeatureImpl.AfterRegistrationAccessImpl a = (FeatureImpl.AfterRegistrationAccessImpl) access;
+        cl = a.getImageClassLoader().getClassLoader();
+        ImageSingletons.add(PreMainSupport.class, preMainSupport = new PreMainSupport());
+        if(Options.PremainClasses.hasBeenSet()) {
+            List<String> premains = Options.PremainClasses.getValue().values();
+            for (String premain : premains) {
+                addPremainClass(premain);
+            }
+        }
+    }
+
+
+    /**
+     * Find the premain method from the given class and register it for runtime usage. According
+     * to java.lang.instrument <a
+     * href=https://docs.oracle.com/en/java/javase/17/docs/api/java.instrument/java/lang/instrument/package-summary.html>API
+     * doc</a>, there are two premain methods:
+     * <ol>
+     * <li>{@code public static void premain(String agentArgs, Instrumentation inst)}</li>
+     * <li>{@code public static void premain(String agentArgs)}</li>
+     * </ol>
+     * The first one is taken with higher priority. The second one is taken only when the first
+     * one is absent. <br>
+     * So this method looks for them in the same order.
+     */
+    private void addPremainClass(String premainClass) {
+        try {
+            Class<?> clazz = Class.forName(premainClass, false, cl);
+            Method premain = null;
+            List<Object> args = new ArrayList<>();
+            args.add(""); // First argument is options which will be set at runtime
+            try {
+                premain = clazz.getDeclaredMethod("premain", String.class, Instrumentation.class);
+                args.add(new PreMainSupport.SVMRuntimeInstrumentImpl());
+            } catch (NoSuchMethodException e) {
+                try {
+                    premain = clazz.getDeclaredMethod("premain", String.class);
+                } catch (NoSuchMethodException e1) {
+                    VMError.shouldNotReachHere("Can't find premain method in " + premainClass, e1);
+                }
+            }
+            preMainSupport.registerPremainMethod(premainClass, premain, args.toArray(new Object[0]));
+        } catch (ClassNotFoundException e) {
+            VMError.shouldNotReachHere("Can't register agent premain method, because the declaring class " + premainClass + " is not found", e);
+        }
+    }
+
+
+}
diff --git a/substratevm/src/com.oracle.svm.hosted/src/com/oracle/svm/hosted/NativeImageGeneratorRunner.java b/substratevm/src/com.oracle.svm.hosted/src/com/oracle/svm/hosted/NativeImageGeneratorRunner.java
index b2ce35238117b..53bd97a958102 100644
--- a/substratevm/src/com.oracle.svm.hosted/src/com/oracle/svm/hosted/NativeImageGeneratorRunner.java
+++ b/substratevm/src/com.oracle.svm.hosted/src/com/oracle/svm/hosted/NativeImageGeneratorRunner.java
@@ -189,6 +189,7 @@ private static void checkBootModuleDependencies(boolean verbose) {
 
         Set<String> expectedBuilderDependencies = Set.of(
                         "java.base",
+                        "java.instrument",
                         "java.management",
                         "java.logging",
                         // workaround for GR-47773 on the module-path which requires java.sql (like