diff --git a/docs/tutorials/databases_klifs.ipynb b/docs/tutorials/databases_klifs.ipynb
index f14abb6a..0dfb7ff6 100644
--- a/docs/tutorials/databases_klifs.ipynb
+++ b/docs/tutorials/databases_klifs.ipynb
@@ -102,16 +102,7 @@
    "cell_type": "code",
    "execution_count": 5,
    "metadata": {},
-   "outputs": [
-    {
-     "name": "stderr",
-     "output_type": "stream",
-     "text": [
-      "INFO:opencadd.databases.klifs.api:Set up remote session...\n",
-      "INFO:opencadd.databases.klifs.api:Remote session is ready!\n"
-     ]
-    }
-   ],
+   "outputs": [],
    "source": [
     "remote = setup_remote()"
    ]
@@ -154,21 +145,7 @@
    "cell_type": "code",
    "execution_count": 7,
    "metadata": {},
-   "outputs": [
-    {
-     "name": "stderr",
-     "output_type": "stream",
-     "text": [
-      "INFO:opencadd.databases.klifs.api:Set up local session...\n",
-      "INFO:opencadd.databases.klifs.local:Load overview.csv...\n",
-      "INFO:opencadd.databases.klifs.local:Load KLIFS_export.csv...\n",
-      "INFO:opencadd.databases.klifs.local:Merge both csv files...\n",
-      "INFO:opencadd.databases.klifs.local:Add paths to coordinate folders to structures...\n",
-      "INFO:opencadd.databases.klifs.local:Add KLIFS IDs to structures (uses remote since not available locally!)...\n",
-      "INFO:opencadd.databases.klifs.api:Local session is ready!\n"
-     ]
-    }
-   ],
+   "outputs": [],
    "source": [
     "local = setup_local(\"../../opencadd/tests/data/klifs\")"
    ]
@@ -263,18 +240,18 @@
        "      <td>4</td>\n",
        "      <td>0</td>\n",
        "      <td>0000000000000010000001000000000000000000000000...</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>1</td>\n",
-       "      <td>1</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
+       "      <td>0.0</td>\n",
+       "      <td>0.0</td>\n",
+       "      <td>1.0</td>\n",
+       "      <td>1.0</td>\n",
+       "      <td>0.0</td>\n",
+       "      <td>0.0</td>\n",
+       "      <td>0.0</td>\n",
+       "      <td>0.0</td>\n",
+       "      <td>0.0</td>\n",
+       "      <td>0.0</td>\n",
+       "      <td>0.0</td>\n",
+       "      <td>0.0</td>\n",
        "      <td>[BMX]</td>\n",
        "      <td>BMX</td>\n",
        "      <td>BMX</td>\n",
@@ -304,18 +281,18 @@
        "      <td>7</td>\n",
        "      <td>61</td>\n",
        "      <td>0000000000000000000000000000000000000000000000...</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>1</td>\n",
-       "      <td>1</td>\n",
-       "      <td>1</td>\n",
-       "      <td>1</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
+       "      <td>0.0</td>\n",
+       "      <td>0.0</td>\n",
+       "      <td>1.0</td>\n",
+       "      <td>1.0</td>\n",
+       "      <td>1.0</td>\n",
+       "      <td>1.0</td>\n",
+       "      <td>0.0</td>\n",
+       "      <td>0.0</td>\n",
+       "      <td>0.0</td>\n",
+       "      <td>0.0</td>\n",
+       "      <td>0.0</td>\n",
+       "      <td>0.0</td>\n",
        "      <td>[BRAF]</td>\n",
        "      <td>BRAF</td>\n",
        "      <td>BRAF</td>\n",
@@ -330,163 +307,219 @@
        "      <td>509</td>\n",
        "    </tr>\n",
        "    <tr>\n",
-       "      <th>2</th>\n",
-       "      <td>Mouse</td>\n",
-       "      <td>1fpu</td>\n",
+       "      <th>...</th>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "    </tr>\n",
+       "    <tr>\n",
+       "      <th>4</th>\n",
+       "      <td>Human</td>\n",
+       "      <td>7lht</td>\n",
        "      <td>-</td>\n",
        "      <td>A</td>\n",
-       "      <td>PRC</td>\n",
        "      <td>-</td>\n",
-       "      <td>0.925</td>\n",
-       "      <td>2.319</td>\n",
-       "      <td>8.8</td>\n",
-       "      <td>HKLGGGQYGEVYEVAVKTLEFLKEAAVMKEIKPNLVQLLGVYIITE...</td>\n",
-       "      <td>2.40</td>\n",
-       "      <td>0</td>\n",
-       "      <td>8</td>\n",
-       "      <td>0000000000000010000000000000000000000000000000...</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>1</td>\n",
-       "      <td>1</td>\n",
-       "      <td>0</td>\n",
+       "      <td>ATP</td>\n",
+       "      <td>10.267</td>\n",
+       "      <td>15.045</td>\n",
+       "      <td>4.0</td>\n",
+       "      <td>KALGKGLFSMVIRITLKVVGLRILNLPHLILEYCKAKDIIRFLQQK...</td>\n",
+       "      <td>3.50</td>\n",
        "      <td>0</td>\n",
        "      <td>0</td>\n",
-       "      <td>1</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>[Abl1, ABL1]</td>\n",
-       "      <td>Abl1</td>\n",
-       "      <td>ABL1</td>\n",
-       "      <td>Abl</td>\n",
-       "      <td>TK</td>\n",
-       "      <td>N-[4-METHYL-3-[[4-(3-PYRIDINYL)-2-PYRIMIDINYL]...</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>[LRRK2]</td>\n",
+       "      <td>LRRK2</td>\n",
+       "      <td>LRRK2</td>\n",
+       "      <td>LRRK</td>\n",
+       "      <td>TKL</td>\n",
        "      <td>-</td>\n",
+       "      <td>ADENOSINE-5&amp;apos;-TRIPHOSPHATE</td>\n",
        "      <td>out</td>\n",
        "      <td>out</td>\n",
-       "      <td>MOUSE/ABL1/1fpu_chainA</td>\n",
-       "      <td>5728</td>\n",
-       "      <td>532</td>\n",
+       "      <td>HUMAN/LRRK2/7lht_chainA</td>\n",
+       "      <td>13623</td>\n",
+       "      <td>495</td>\n",
        "    </tr>\n",
        "    <tr>\n",
-       "      <th>3</th>\n",
-       "      <td>Mouse</td>\n",
-       "      <td>1fpu</td>\n",
+       "      <th>5</th>\n",
+       "      <td>Human</td>\n",
+       "      <td>2ogv</td>\n",
        "      <td>-</td>\n",
-       "      <td>B</td>\n",
-       "      <td>PRC</td>\n",
+       "      <td>A</td>\n",
        "      <td>-</td>\n",
-       "      <td>0.925</td>\n",
-       "      <td>2.329</td>\n",
-       "      <td>9.2</td>\n",
-       "      <td>HKLGGGQYGEVYEVAVKTLEFLKEAAVMKEIKPNLVQLLGVYIITE...</td>\n",
-       "      <td>2.40</td>\n",
-       "      <td>0</td>\n",
-       "      <td>4</td>\n",
-       "      <td>0000000000000010000000000000000000000000000000...</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>1</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>1</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
+       "      <td>-</td>\n",
+       "      <td>1.043</td>\n",
+       "      <td>2.362</td>\n",
+       "      <td>6.4</td>\n",
+       "      <td>KTLGAGAFGKVVEVAVKMLALMSELKIMSHLGENIVNLLGALVITE...</td>\n",
+       "      <td>2.70</td>\n",
+       "      <td>2</td>\n",
        "      <td>0</td>\n",
-       "      <td>[Abl1, ABL1]</td>\n",
-       "      <td>Abl1</td>\n",
-       "      <td>ABL1</td>\n",
-       "      <td>Abl</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>[CSF1R, FMS]</td>\n",
+       "      <td>CSF1R</td>\n",
+       "      <td>FMS</td>\n",
+       "      <td>PDGFR</td>\n",
        "      <td>TK</td>\n",
-       "      <td>N-[4-METHYL-3-[[4-(3-PYRIDINYL)-2-PYRIMIDINYL]...</td>\n",
+       "      <td>-</td>\n",
        "      <td>-</td>\n",
        "      <td>out</td>\n",
-       "      <td>out</td>\n",
-       "      <td>MOUSE/ABL1/1fpu_chainB</td>\n",
-       "      <td>5705</td>\n",
-       "      <td>532</td>\n",
+       "      <td>in</td>\n",
+       "      <td>HUMAN/FMS/2ogv_chainA</td>\n",
+       "      <td>1243</td>\n",
+       "      <td>449</td>\n",
        "    </tr>\n",
        "  </tbody>\n",
        "</table>\n",
+       "<p>6 rows × 38 columns</p>\n",
        "</div>"
       ],
       "text/plain": [
-       "  species.klifs structure.pdb_id structure.alternate_model structure.chain  \\\n",
-       "0         Human             3sxr                         -               A   \n",
-       "1         Human             6uuo                         -               A   \n",
-       "2         Mouse             1fpu                         -               A   \n",
-       "3         Mouse             1fpu                         -               B   \n",
-       "\n",
-       "  ligand.expo_id ligand_allosteric.expo_id  structure.rmsd1  structure.rmsd2  \\\n",
-       "0            1N1                         -            0.839            1.967   \n",
-       "1            QH1                         -            0.806            2.028   \n",
-       "2            PRC                         -            0.925            2.319   \n",
-       "3            PRC                         -            0.925            2.329   \n",
-       "\n",
-       "   structure.qualityscore                                   structure.pocket  \\\n",
-       "0                     6.4  KELGS____VVKLVAVKMIEFFQEAQTMMKLSPKLVKFYGVYIVTE...   \n",
-       "1                     5.2  QRI____FGTVYKVAVKMLAFKNEVGVLRKTRVNILLFMGYAIVTQ...   \n",
-       "2                     8.8  HKLGGGQYGEVYEVAVKTLEFLKEAAVMKEIKPNLVQLLGVYIITE...   \n",
-       "3                     9.2  HKLGGGQYGEVYEVAVKTLEFLKEAAVMKEIKPNLVQLLGVYIITE...   \n",
-       "\n",
-       "   structure.resolution  structure.missing_residues  structure.missing_atoms  \\\n",
-       "0                  2.40                           4                        0   \n",
-       "1                  3.29                           7                       61   \n",
-       "2                  2.40                           0                        8   \n",
-       "3                  2.40                           0                        4   \n",
-       "\n",
-       "                             interaction.fingerprint  structure.fp_i  \\\n",
-       "0  0000000000000010000001000000000000000000000000...               0   \n",
-       "1  0000000000000000000000000000000000000000000000...               0   \n",
-       "2  0000000000000010000000000000000000000000000000...               0   \n",
-       "3  0000000000000010000000000000000000000000000000...               0   \n",
-       "\n",
-       "   structure.fp_ii  structure.bp_i_a  structure.bp_i_b  structure.bp_ii_in  \\\n",
-       "0                0                 1                 1                   0   \n",
-       "1                0                 1                 1                   1   \n",
-       "2                0                 1                 1                   0   \n",
-       "3                0                 0                 1                   0   \n",
+       "   species.klifs structure.pdb_id structure.alternate_model structure.chain  \\\n",
+       "0          Human             3sxr                         -               A   \n",
+       "1          Human             6uuo                         -               A   \n",
+       "..           ...              ...                       ...             ...   \n",
+       "4          Human             7lht                         -               A   \n",
+       "5          Human             2ogv                         -               A   \n",
+       "\n",
+       "   ligand.expo_id ligand_allosteric.expo_id  structure.rmsd1  structure.rmsd2  \\\n",
+       "0             1N1                         -            0.839            1.967   \n",
+       "1             QH1                         -            0.806            2.028   \n",
+       "..            ...                       ...              ...              ...   \n",
+       "4               -                       ATP           10.267           15.045   \n",
+       "5               -                         -            1.043            2.362   \n",
+       "\n",
+       "    structure.qualityscore                                   structure.pocket  \\\n",
+       "0                      6.4  KELGS____VVKLVAVKMIEFFQEAQTMMKLSPKLVKFYGVYIVTE...   \n",
+       "1                      5.2  QRI____FGTVYKVAVKMLAFKNEVGVLRKTRVNILLFMGYAIVTQ...   \n",
+       "..                     ...                                                ...   \n",
+       "4                      4.0  KALGKGLFSMVIRITLKVVGLRILNLPHLILEYCKAKDIIRFLQQK...   \n",
+       "5                      6.4  KTLGAGAFGKVVEVAVKMLALMSELKIMSHLGENIVNLLGALVITE...   \n",
+       "\n",
+       "    structure.resolution  structure.missing_residues  structure.missing_atoms  \\\n",
+       "0                   2.40                           4                        0   \n",
+       "1                   3.29                           7                       61   \n",
+       "..                   ...                         ...                      ...   \n",
+       "4                   3.50                           0                        0   \n",
+       "5                   2.70                           2                        0   \n",
+       "\n",
+       "                              interaction.fingerprint  structure.fp_i  \\\n",
+       "0   0000000000000010000001000000000000000000000000...             0.0   \n",
+       "1   0000000000000000000000000000000000000000000000...             0.0   \n",
+       "..                                                ...             ...   \n",
+       "4                                                 NaN             NaN   \n",
+       "5                                                 NaN             NaN   \n",
        "\n",
-       "   structure.bp_ii_a_in  structure.bp_ii_b_in  structure.bp_ii_out  \\\n",
-       "0                     0                     0                    0   \n",
-       "1                     1                     0                    0   \n",
-       "2                     0                     0                    1   \n",
-       "3                     0                     0                    1   \n",
-       "\n",
-       "   structure.bp_ii_b  structure.bp_iii  structure.bp_iv  structure.bp_v  \\\n",
-       "0                  0                 0                0               0   \n",
-       "1                  0                 0                0               0   \n",
-       "2                  0                 0                0               0   \n",
-       "3                  0                 0                0               0   \n",
+       "    structure.fp_ii  structure.bp_i_a  structure.bp_i_b  structure.bp_ii_in  \\\n",
+       "0               0.0               1.0               1.0                 0.0   \n",
+       "1               0.0               1.0               1.0                 1.0   \n",
+       "..              ...               ...               ...                 ...   \n",
+       "4               NaN               NaN               NaN                 NaN   \n",
+       "5               NaN               NaN               NaN                 NaN   \n",
        "\n",
-       "   kinase.names kinase.gene_name kinase.klifs_name kinase.family kinase.group  \\\n",
-       "0         [BMX]              BMX               BMX           Tec           TK   \n",
-       "1        [BRAF]             BRAF              BRAF           RAF          TKL   \n",
-       "2  [Abl1, ABL1]             Abl1              ABL1           Abl           TK   \n",
-       "3  [Abl1, ABL1]             Abl1              ABL1           Abl           TK   \n",
+       "    structure.bp_ii_a_in  structure.bp_ii_b_in  structure.bp_ii_out  \\\n",
+       "0                    0.0                   0.0                  0.0   \n",
+       "1                    1.0                   0.0                  0.0   \n",
+       "..                   ...                   ...                  ...   \n",
+       "4                    NaN                   NaN                  NaN   \n",
+       "5                    NaN                   NaN                  NaN   \n",
        "\n",
-       "                                         ligand.name ligand_allosteric.name  \\\n",
-       "0  N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROX...                      -   \n",
-       "1  1-[4-{[1-(3-{[dihydroxy(propyl)-lambda~4~-sulf...                      -   \n",
-       "2  N-[4-METHYL-3-[[4-(3-PYRIDINYL)-2-PYRIMIDINYL]...                      -   \n",
-       "3  N-[4-METHYL-3-[[4-(3-PYRIDINYL)-2-PYRIMIDINYL]...                      -   \n",
-       "\n",
-       "  structure.dfg structure.ac_helix      structure.filepath  \\\n",
-       "0      out-like                 in   HUMAN/BMX/3sxr_chainA   \n",
-       "1            in           out-like  HUMAN/BRAF/6uuo_chainA   \n",
-       "2           out                out  MOUSE/ABL1/1fpu_chainA   \n",
-       "3           out                out  MOUSE/ABL1/1fpu_chainB   \n",
-       "\n",
-       "   structure.klifs_id  kinase.klifs_id  \n",
-       "0                3482              472  \n",
-       "1               12347              509  \n",
-       "2                5728              532  \n",
-       "3                5705              532  "
+       "    structure.bp_ii_b  structure.bp_iii  structure.bp_iv  structure.bp_v  \\\n",
+       "0                 0.0               0.0              0.0             0.0   \n",
+       "1                 0.0               0.0              0.0             0.0   \n",
+       "..                ...               ...              ...             ...   \n",
+       "4                 NaN               NaN              NaN             NaN   \n",
+       "5                 NaN               NaN              NaN             NaN   \n",
+       "\n",
+       "    kinase.names kinase.gene_name kinase.klifs_name kinase.family  \\\n",
+       "0          [BMX]              BMX               BMX           Tec   \n",
+       "1         [BRAF]             BRAF              BRAF           RAF   \n",
+       "..           ...              ...               ...           ...   \n",
+       "4        [LRRK2]            LRRK2             LRRK2          LRRK   \n",
+       "5   [CSF1R, FMS]            CSF1R               FMS         PDGFR   \n",
+       "\n",
+       "   kinase.group                                        ligand.name  \\\n",
+       "0            TK  N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROX...   \n",
+       "1           TKL  1-[4-{[1-(3-{[dihydroxy(propyl)-lambda~4~-sulf...   \n",
+       "..          ...                                                ...   \n",
+       "4           TKL                                                  -   \n",
+       "5            TK                                                  -   \n",
+       "\n",
+       "            ligand_allosteric.name structure.dfg structure.ac_helix  \\\n",
+       "0                                -      out-like                 in   \n",
+       "1                                -            in           out-like   \n",
+       "..                             ...           ...                ...   \n",
+       "4   ADENOSINE-5&apos;-TRIPHOSPHATE           out                out   \n",
+       "5                                -           out                 in   \n",
+       "\n",
+       "         structure.filepath  structure.klifs_id  kinase.klifs_id  \n",
+       "0     HUMAN/BMX/3sxr_chainA                3482              472  \n",
+       "1    HUMAN/BRAF/6uuo_chainA               12347              509  \n",
+       "..                      ...                 ...              ...  \n",
+       "4   HUMAN/LRRK2/7lht_chainA               13623              495  \n",
+       "5     HUMAN/FMS/2ogv_chainA                1243              449  \n",
+       "\n",
+       "[6 rows x 38 columns]"
       ]
      },
      "execution_count": 8,
@@ -528,14 +561,12 @@
     "|:--------------------------| -  | -  | -  | -       | -  | -  |\n",
     "| __by_kinase_klifs_id__    | x* | x* | x* |         | x  |    | \n",
     "| __by_kinase_name__        | x* | x  | x  |         |    |    |\n",
-    "| __by_ligand_klifs_id__    |    | x* | x  | x\\* \\** | x  |    |\n",
-    "| __by_ligand_expo_id__     |    | x  | x  | x\\* \\** |    |    |\n",
+    "| __by_ligand_klifs_id__    |    | x* | x  | x*      | x  |    |\n",
+    "| __by_ligand_expo_id__     |    | x  | x  | x*      |    |    |\n",
     "| __by_structure_klifs_id__ |    |    | x* |         | x* | x* |\n",
     "| __by_structure_pdb_id__   |    |    | x* |         |    |    |\n",
     "\n",
-    " \\* Direct use of KLIFS Swagger API.\n",
-    " \n",
-    " \\** KLIFS Swagger API allows only ONE input value."
+    " \\* Direct use of KLIFS Swagger API."
    ]
   },
   {
@@ -937,6 +968,14 @@
        "      <th>2</th>\n",
        "      <td>Abl</td>\n",
        "    </tr>\n",
+       "    <tr>\n",
+       "      <th>3</th>\n",
+       "      <td>LRRK</td>\n",
+       "    </tr>\n",
+       "    <tr>\n",
+       "      <th>4</th>\n",
+       "      <td>PDGFR</td>\n",
+       "    </tr>\n",
        "  </tbody>\n",
        "</table>\n",
        "</div>"
@@ -945,7 +984,9 @@
        "  kinase.family\n",
        "0           Tec\n",
        "1           RAF\n",
-       "2           Abl"
+       "2           Abl\n",
+       "3          LRRK\n",
+       "4         PDGFR"
       ]
      },
      "execution_count": 14,
@@ -995,6 +1036,10 @@
        "      <th>1</th>\n",
        "      <td>Abl</td>\n",
        "    </tr>\n",
+       "    <tr>\n",
+       "      <th>2</th>\n",
+       "      <td>PDGFR</td>\n",
+       "    </tr>\n",
        "  </tbody>\n",
        "</table>\n",
        "</div>"
@@ -1002,7 +1047,8 @@
       "text/plain": [
        "  kinase.family\n",
        "0           Tec\n",
-       "1           Abl"
+       "1           Abl\n",
+       "2         PDGFR"
       ]
      },
      "execution_count": 15,
@@ -1351,9 +1397,9 @@
        "      <th>0</th>\n",
        "      <td>472</td>\n",
        "      <td>BMX</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>BMX</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>Human</td>\n",
        "    </tr>\n",
        "  </tbody>\n",
@@ -1362,10 +1408,10 @@
       ],
       "text/plain": [
        "   kinase.klifs_id kinase.klifs_name kinase.full_name kinase.gene_name  \\\n",
-       "0              472               BMX             None              BMX   \n",
+       "0              472               BMX             <NA>              BMX   \n",
        "\n",
        "  kinase.uniprot species.klifs  \n",
-       "0           None         Human  "
+       "0           <NA>         Human  "
       ]
      },
      "execution_count": 20,
@@ -1416,9 +1462,9 @@
        "      <th>0</th>\n",
        "      <td>532</td>\n",
        "      <td>ABL1</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>Abl1</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>Mouse</td>\n",
        "    </tr>\n",
        "  </tbody>\n",
@@ -1427,10 +1473,10 @@
       ],
       "text/plain": [
        "   kinase.klifs_id kinase.klifs_name kinase.full_name kinase.gene_name  \\\n",
-       "0              532              ABL1             None             Abl1   \n",
+       "0              532              ABL1             <NA>             Abl1   \n",
        "\n",
        "  kinase.uniprot species.klifs  \n",
-       "0           None         Mouse  "
+       "0           <NA>         Mouse  "
       ]
      },
      "execution_count": 21,
@@ -1508,7 +1554,7 @@
        "      <th>kinase.gene_name</th>\n",
        "      <th>kinase.family</th>\n",
        "      <th>kinase.group</th>\n",
-       "      <th>kinase.class</th>\n",
+       "      <th>kinase.subfamily</th>\n",
        "      <th>species.klifs</th>\n",
        "      <th>kinase.uniprot</th>\n",
        "      <th>kinase.iuphar</th>\n",
@@ -1541,11 +1587,11 @@
        "                                kinase.full_name kinase.gene_name  \\\n",
        "0  v-akt murine thymoma viral oncogene homolog 1             AKT1   \n",
        "\n",
-       "  kinase.family kinase.group kinase.class species.klifs kinase.uniprot  \\\n",
-       "0           Akt          AGC                      Human         P31749   \n",
+       "  kinase.family kinase.group kinase.subfamily species.klifs kinase.uniprot  \\\n",
+       "0           Akt          AGC                          Human         P31749   \n",
        "\n",
-       "   kinase.iuphar                                      kinase.pocket  \n",
-       "0           1479  KLLGKGTFGKVILYAMKILHTLTENRVLQNSRPFLTALKYSCFVME...  "
+       "  kinase.iuphar                                      kinase.pocket  \n",
+       "0          1479  KLLGKGTFGKVILYAMKILHTLTENRVLQNSRPFLTALKYSCFVME...  "
       ]
      },
      "execution_count": 23,
@@ -1589,7 +1635,7 @@
        "      <th>kinase.gene_name</th>\n",
        "      <th>kinase.family</th>\n",
        "      <th>kinase.group</th>\n",
-       "      <th>kinase.class</th>\n",
+       "      <th>kinase.subfamily</th>\n",
        "      <th>species.klifs</th>\n",
        "      <th>kinase.uniprot</th>\n",
        "      <th>kinase.iuphar</th>\n",
@@ -1638,13 +1684,13 @@
        "0  v-akt murine thymoma viral oncogene homolog 1             AKT1   \n",
        "1  v-akt murine thymoma viral oncogene homolog 2             AKT2   \n",
        "\n",
-       "  kinase.family kinase.group kinase.class species.klifs kinase.uniprot  \\\n",
-       "0           Akt          AGC                      Human         P31749   \n",
-       "1           Akt          AGC                      Human         P31751   \n",
+       "  kinase.family kinase.group kinase.subfamily species.klifs kinase.uniprot  \\\n",
+       "0           Akt          AGC                          Human         P31749   \n",
+       "1           Akt          AGC                          Human         P31751   \n",
        "\n",
-       "   kinase.iuphar                                      kinase.pocket  \n",
-       "0           1479  KLLGKGTFGKVILYAMKILHTLTENRVLQNSRPFLTALKYSCFVME...  \n",
-       "1           1480  KLLGKGTFGKVILYAMKILHTVTESRVLQNTRPFLTALKYACFVME...  "
+       "  kinase.iuphar                                      kinase.pocket  \n",
+       "0          1479  KLLGKGTFGKVILYAMKILHTLTENRVLQNSRPFLTALKYSCFVME...  \n",
+       "1          1480  KLLGKGTFGKVILYAMKILHTVTESRVLQNTRPFLTALKYACFVME...  "
       ]
      },
      "execution_count": 24,
@@ -1715,7 +1761,7 @@
        "      <th>kinase.gene_name</th>\n",
        "      <th>kinase.family</th>\n",
        "      <th>kinase.group</th>\n",
-       "      <th>kinase.class</th>\n",
+       "      <th>kinase.subfamily</th>\n",
        "      <th>species.klifs</th>\n",
        "      <th>kinase.uniprot</th>\n",
        "      <th>kinase.iuphar</th>\n",
@@ -1727,15 +1773,15 @@
        "      <th>0</th>\n",
        "      <td>472</td>\n",
        "      <td>BMX</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>BMX</td>\n",
        "      <td>Tec</td>\n",
        "      <td>TK</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>Human</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "    </tr>\n",
        "  </tbody>\n",
        "</table>\n",
@@ -1743,13 +1789,13 @@
       ],
       "text/plain": [
        "   kinase.klifs_id kinase.klifs_name kinase.full_name kinase.gene_name  \\\n",
-       "0              472               BMX             None              BMX   \n",
+       "0              472               BMX             <NA>              BMX   \n",
        "\n",
-       "  kinase.family kinase.group kinase.class species.klifs kinase.uniprot  \\\n",
-       "0           Tec           TK         None         Human           None   \n",
+       "  kinase.family kinase.group kinase.subfamily species.klifs kinase.uniprot  \\\n",
+       "0           Tec           TK             <NA>         Human           <NA>   \n",
        "\n",
        "  kinase.iuphar kinase.pocket  \n",
-       "0          None          None  "
+       "0          <NA>          <NA>  "
       ]
      },
      "execution_count": 26,
@@ -1793,7 +1839,7 @@
        "      <th>kinase.gene_name</th>\n",
        "      <th>kinase.family</th>\n",
        "      <th>kinase.group</th>\n",
-       "      <th>kinase.class</th>\n",
+       "      <th>kinase.subfamily</th>\n",
        "      <th>species.klifs</th>\n",
        "      <th>kinase.uniprot</th>\n",
        "      <th>kinase.iuphar</th>\n",
@@ -1805,29 +1851,29 @@
        "      <th>0</th>\n",
        "      <td>472</td>\n",
        "      <td>BMX</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>BMX</td>\n",
        "      <td>Tec</td>\n",
        "      <td>TK</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>Human</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>1</th>\n",
        "      <td>509</td>\n",
        "      <td>BRAF</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>BRAF</td>\n",
        "      <td>RAF</td>\n",
        "      <td>TKL</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>Human</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "    </tr>\n",
        "  </tbody>\n",
        "</table>\n",
@@ -1835,16 +1881,16 @@
       ],
       "text/plain": [
        "   kinase.klifs_id kinase.klifs_name kinase.full_name kinase.gene_name  \\\n",
-       "0              472               BMX             None              BMX   \n",
-       "1              509              BRAF             None             BRAF   \n",
+       "0              472               BMX             <NA>              BMX   \n",
+       "1              509              BRAF             <NA>             BRAF   \n",
        "\n",
-       "  kinase.family kinase.group kinase.class species.klifs kinase.uniprot  \\\n",
-       "0           Tec           TK         None         Human           None   \n",
-       "1           RAF          TKL         None         Human           None   \n",
+       "  kinase.family kinase.group kinase.subfamily species.klifs kinase.uniprot  \\\n",
+       "0           Tec           TK             <NA>         Human           <NA>   \n",
+       "1           RAF          TKL             <NA>         Human           <NA>   \n",
        "\n",
        "  kinase.iuphar kinase.pocket  \n",
-       "0          None          None  \n",
-       "1          None          None  "
+       "0          <NA>          <NA>  \n",
+       "1          <NA>          <NA>  "
       ]
      },
      "execution_count": 27,
@@ -1922,7 +1968,7 @@
        "      <th>kinase.gene_name</th>\n",
        "      <th>kinase.family</th>\n",
        "      <th>kinase.group</th>\n",
-       "      <th>kinase.class</th>\n",
+       "      <th>kinase.subfamily</th>\n",
        "      <th>species.klifs</th>\n",
        "      <th>kinase.uniprot</th>\n",
        "      <th>kinase.iuphar</th>\n",
@@ -1967,13 +2013,13 @@
        "0              574               BMX  BMX non-receptor tyrosine kinase   \n",
        "1              472               BMX  BMX non-receptor tyrosine kinase   \n",
        "\n",
-       "  kinase.gene_name kinase.family kinase.group kinase.class species.klifs  \\\n",
-       "0              Bmx           Tec           TK                      Mouse   \n",
-       "1              BMX           Tec           TK                      Human   \n",
+       "  kinase.gene_name kinase.family kinase.group kinase.subfamily species.klifs  \\\n",
+       "0              Bmx           Tec           TK                          Mouse   \n",
+       "1              BMX           Tec           TK                          Human   \n",
        "\n",
-       "  kinase.uniprot  kinase.iuphar  \\\n",
-       "0         P97504              0   \n",
-       "1         P51813           1942   \n",
+       "  kinase.uniprot kinase.iuphar  \\\n",
+       "0         P97504             0   \n",
+       "1         P51813          1942   \n",
        "\n",
        "                                       kinase.pocket  \n",
        "0  KELGNGQFGVVQLVAVKMIEFFQEAQTMMKLSPKLVKFYGVYIVTE...  \n",
@@ -2021,7 +2067,7 @@
        "      <th>kinase.gene_name</th>\n",
        "      <th>kinase.family</th>\n",
        "      <th>kinase.group</th>\n",
-       "      <th>kinase.class</th>\n",
+       "      <th>kinase.subfamily</th>\n",
        "      <th>species.klifs</th>\n",
        "      <th>kinase.uniprot</th>\n",
        "      <th>kinase.iuphar</th>\n",
@@ -2066,13 +2112,13 @@
        "0              574               BMX  BMX non-receptor tyrosine kinase   \n",
        "1              472               BMX  BMX non-receptor tyrosine kinase   \n",
        "\n",
-       "  kinase.gene_name kinase.family kinase.group kinase.class species.klifs  \\\n",
-       "0              Bmx           Tec           TK                      Mouse   \n",
-       "1              BMX           Tec           TK                      Human   \n",
+       "  kinase.gene_name kinase.family kinase.group kinase.subfamily species.klifs  \\\n",
+       "0              Bmx           Tec           TK                          Mouse   \n",
+       "1              BMX           Tec           TK                          Human   \n",
        "\n",
-       "  kinase.uniprot  kinase.iuphar  \\\n",
-       "0         P97504              0   \n",
-       "1         P51813           1942   \n",
+       "  kinase.uniprot kinase.iuphar  \\\n",
+       "0         P97504             0   \n",
+       "1         P51813          1942   \n",
        "\n",
        "                                       kinase.pocket  \n",
        "0  KELGNGQFGVVQLVAVKMIEFFQEAQTMMKLSPKLVKFYGVYIVTE...  \n",
@@ -2140,7 +2186,7 @@
        "      <th>kinase.gene_name</th>\n",
        "      <th>kinase.family</th>\n",
        "      <th>kinase.group</th>\n",
-       "      <th>kinase.class</th>\n",
+       "      <th>kinase.subfamily</th>\n",
        "      <th>species.klifs</th>\n",
        "      <th>kinase.uniprot</th>\n",
        "      <th>kinase.iuphar</th>\n",
@@ -2189,13 +2235,13 @@
        "0  B-Raf proto-oncogene, serine/threonine kinase             BRAF   \n",
        "1               BMX non-receptor tyrosine kinase              BMX   \n",
        "\n",
-       "  kinase.family kinase.group kinase.class species.klifs kinase.uniprot  \\\n",
-       "0           RAF          TKL          RAF         Human         P15056   \n",
-       "1           Tec           TK                      Human         P51813   \n",
+       "  kinase.family kinase.group kinase.subfamily species.klifs kinase.uniprot  \\\n",
+       "0           RAF          TKL              RAF         Human         P15056   \n",
+       "1           Tec           TK                          Human         P51813   \n",
        "\n",
-       "   kinase.iuphar                                      kinase.pocket  \n",
-       "0           1943  QRIGSGSFGTVYKVAVKMLAFKNEVGVLRKTRVNILLFMGYAIVTQ...  \n",
-       "1           1942  KELGSGQFGVVQLVAVKMIEFFQEAQTMMKLSPKLVKFYGVYIVTE...  "
+       "  kinase.iuphar                                      kinase.pocket  \n",
+       "0          1943  QRIGSGSFGTVYKVAVKMLAFKNEVGVLRKTRVNILLFMGYAIVTQ...  \n",
+       "1          1942  KELGSGQFGVVQLVAVKMIEFFQEAQTMMKLSPKLVKFYGVYIVTE...  "
       ]
      },
      "execution_count": 32,
@@ -2246,7 +2292,7 @@
        "      <th>kinase.gene_name</th>\n",
        "      <th>kinase.family</th>\n",
        "      <th>kinase.group</th>\n",
-       "      <th>kinase.class</th>\n",
+       "      <th>kinase.subfamily</th>\n",
        "      <th>species.klifs</th>\n",
        "      <th>kinase.uniprot</th>\n",
        "      <th>kinase.iuphar</th>\n",
@@ -2258,15 +2304,15 @@
        "      <th>0</th>\n",
        "      <td>472</td>\n",
        "      <td>BMX</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>BMX</td>\n",
        "      <td>Tec</td>\n",
        "      <td>TK</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>Human</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "    </tr>\n",
        "  </tbody>\n",
        "</table>\n",
@@ -2274,13 +2320,13 @@
       ],
       "text/plain": [
        "   kinase.klifs_id kinase.klifs_name kinase.full_name kinase.gene_name  \\\n",
-       "0              472               BMX             None              BMX   \n",
+       "0              472               BMX             <NA>              BMX   \n",
        "\n",
-       "  kinase.family kinase.group kinase.class species.klifs kinase.uniprot  \\\n",
-       "0           Tec           TK         None         Human           None   \n",
+       "  kinase.family kinase.group kinase.subfamily species.klifs kinase.uniprot  \\\n",
+       "0           Tec           TK             <NA>         Human           <NA>   \n",
        "\n",
        "  kinase.iuphar kinase.pocket  \n",
-       "0          None          None  "
+       "0          <NA>          <NA>  "
       ]
      },
      "execution_count": 33,
@@ -2344,7 +2390,7 @@
        "      <th>kinase.gene_name</th>\n",
        "      <th>kinase.family</th>\n",
        "      <th>kinase.group</th>\n",
-       "      <th>kinase.class</th>\n",
+       "      <th>kinase.subfamily</th>\n",
        "      <th>species.klifs</th>\n",
        "      <th>kinase.uniprot</th>\n",
        "      <th>kinase.iuphar</th>\n",
@@ -2356,29 +2402,29 @@
        "      <th>0</th>\n",
        "      <td>472</td>\n",
        "      <td>BMX</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>BMX</td>\n",
        "      <td>Tec</td>\n",
        "      <td>TK</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>Human</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>1</th>\n",
        "      <td>509</td>\n",
        "      <td>BRAF</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>BRAF</td>\n",
        "      <td>RAF</td>\n",
        "      <td>TKL</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>Human</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "    </tr>\n",
        "  </tbody>\n",
        "</table>\n",
@@ -2386,16 +2432,16 @@
       ],
       "text/plain": [
        "   kinase.klifs_id kinase.klifs_name kinase.full_name kinase.gene_name  \\\n",
-       "0              472               BMX             None              BMX   \n",
-       "1              509              BRAF             None             BRAF   \n",
+       "0              472               BMX             <NA>              BMX   \n",
+       "1              509              BRAF             <NA>             BRAF   \n",
        "\n",
-       "  kinase.family kinase.group kinase.class species.klifs kinase.uniprot  \\\n",
-       "0           Tec           TK         None         Human           None   \n",
-       "1           RAF          TKL         None         Human           None   \n",
+       "  kinase.family kinase.group kinase.subfamily species.klifs kinase.uniprot  \\\n",
+       "0           Tec           TK             <NA>         Human           <NA>   \n",
+       "1           RAF          TKL             <NA>         Human           <NA>   \n",
        "\n",
        "  kinase.iuphar kinase.pocket  \n",
-       "0          None          None  \n",
-       "1          None          None  "
+       "0          <NA>          <NA>  \n",
+       "1          <NA>          <NA>  "
       ]
      },
      "execution_count": 35,
@@ -2595,47 +2641,58 @@
        "  <tbody>\n",
        "    <tr>\n",
        "      <th>0</th>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>1N1</td>\n",
        "      <td>N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROX...</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>1</th>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>QH1</td>\n",
        "      <td>1-[4-{[1-(3-{[dihydroxy(propyl)-lambda~4~-sulf...</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>2</th>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>PRC</td>\n",
        "      <td>N-[4-METHYL-3-[[4-(3-PYRIDINYL)-2-PYRIMIDINYL]...</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "    </tr>\n",
+       "    <tr>\n",
+       "      <th>3</th>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>-</td>\n",
+       "      <td>-</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "    </tr>\n",
        "  </tbody>\n",
        "</table>\n",
        "</div>"
       ],
       "text/plain": [
-       "  ligand.klifs_id ligand.expo_id  \\\n",
-       "0            None            1N1   \n",
-       "1            None            QH1   \n",
-       "2            None            PRC   \n",
+       "   ligand.klifs_id ligand.expo_id  \\\n",
+       "0             <NA>            1N1   \n",
+       "1             <NA>            QH1   \n",
+       "2             <NA>            PRC   \n",
+       "3             <NA>              -   \n",
        "\n",
        "                                         ligand.name ligand.smiles  \\\n",
-       "0  N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROX...          None   \n",
-       "1  1-[4-{[1-(3-{[dihydroxy(propyl)-lambda~4~-sulf...          None   \n",
-       "2  N-[4-METHYL-3-[[4-(3-PYRIDINYL)-2-PYRIMIDINYL]...          None   \n",
+       "0  N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROX...          <NA>   \n",
+       "1  1-[4-{[1-(3-{[dihydroxy(propyl)-lambda~4~-sulf...          <NA>   \n",
+       "2  N-[4-METHYL-3-[[4-(3-PYRIDINYL)-2-PYRIMIDINYL]...          <NA>   \n",
+       "3                                                  -          <NA>   \n",
        "\n",
        "  ligand.inchikey  \n",
-       "0            None  \n",
-       "1            None  \n",
-       "2            None  "
+       "0            <NA>  \n",
+       "1            <NA>  \n",
+       "2            <NA>  \n",
+       "3            <NA>  "
       ]
      },
      "execution_count": 37,
@@ -2676,7 +2733,7 @@
     {
      "data": {
       "application/vnd.jupyter.widget-view+json": {
-       "model_id": "aab889d91de64b29ba449882101d589d",
+       "model_id": "490e594cdbc643c9b105c4924b8e4738",
        "version_major": 2,
        "version_minor": 0
       },
@@ -2787,7 +2844,7 @@
     {
      "data": {
       "application/vnd.jupyter.widget-view+json": {
-       "model_id": "2cf8023b0aef40959214b94a316c2c0e",
+       "model_id": "350de9c0c8fa42caa4a2a98a80ec17e1",
        "version_major": 2,
        "version_minor": 0
       },
@@ -2802,9 +2859,9 @@
      "name": "stderr",
      "output_type": "stream",
      "text": [
-      "ERROR:opencadd.databases.klifs.core:There was (were) 1/3 failed request(s).\n",
+      "There was (were) 1/3 failed request(s).\n",
       "Show error messages (up to 5 messages only):\n",
-      "ERROR:opencadd.databases.klifs.core:Error for 10000: Expected type to be dict for value [400, 'KLIFS error: The provided kinase ID(s) is/are invalid'] to unmarshal to a <class 'abc.Error'>.Was <class 'list'> instead.\n"
+      "Error for 10000: Expected type to be dict for value [400, 'KLIFS error: The provided kinase ID(s) is/are invalid'] to unmarshal to a <class 'abc.Error'>.Was <class 'list'> instead.\n"
      ]
     },
     {
@@ -2936,7 +2993,7 @@
     {
      "data": {
       "application/vnd.jupyter.widget-view+json": {
-       "model_id": "376df0e4170f477093f4b34e09f842b4",
+       "model_id": "00879a77d46a408984bf81abe93b1931",
        "version_major": 2,
        "version_minor": 0
       },
@@ -2951,9 +3008,9 @@
      "name": "stderr",
      "output_type": "stream",
      "text": [
-      "ERROR:opencadd.databases.klifs.core:There was (were) 1/1 failed request(s).\n",
+      "There was (were) 1/1 failed request(s).\n",
       "Show error messages (up to 5 messages only):\n",
-      "ERROR:opencadd.databases.klifs.core:Error for 10000: Expected type to be dict for value [400, 'KLIFS error: The provided kinase ID(s) is/are invalid'] to unmarshal to a <class 'abc.Error'>.Was <class 'list'> instead.\n"
+      "Error for 10000: Expected type to be dict for value [400, 'KLIFS error: The provided kinase ID(s) is/are invalid'] to unmarshal to a <class 'abc.Error'>.Was <class 'list'> instead.\n"
      ]
     },
     {
@@ -3015,11 +3072,11 @@
        "  <tbody>\n",
        "    <tr>\n",
        "      <th>0</th>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>1N1</td>\n",
        "      <td>N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROX...</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>472</td>\n",
        "    </tr>\n",
        "  </tbody>\n",
@@ -3027,14 +3084,14 @@
        "</div>"
       ],
       "text/plain": [
-       "  ligand.klifs_id ligand.expo_id  \\\n",
-       "0            None            1N1   \n",
+       "   ligand.klifs_id ligand.expo_id  \\\n",
+       "0             <NA>            1N1   \n",
        "\n",
        "                                         ligand.name ligand.smiles  \\\n",
-       "0  N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROX...          None   \n",
+       "0  N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROX...          <NA>   \n",
        "\n",
        "  ligand.inchikey  kinase.klifs_id (query)  \n",
-       "0            None                      472  "
+       "0            <NA>                      472  "
       ]
      },
      "execution_count": 41,
@@ -3083,20 +3140,20 @@
        "  <tbody>\n",
        "    <tr>\n",
        "      <th>0</th>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>1N1</td>\n",
        "      <td>N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROX...</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>472</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>1</th>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>QH1</td>\n",
        "      <td>1-[4-{[1-(3-{[dihydroxy(propyl)-lambda~4~-sulf...</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>509</td>\n",
        "    </tr>\n",
        "  </tbody>\n",
@@ -3104,17 +3161,17 @@
        "</div>"
       ],
       "text/plain": [
-       "  ligand.klifs_id ligand.expo_id  \\\n",
-       "0            None            1N1   \n",
-       "1            None            QH1   \n",
+       "   ligand.klifs_id ligand.expo_id  \\\n",
+       "0             <NA>            1N1   \n",
+       "1             <NA>            QH1   \n",
        "\n",
        "                                         ligand.name ligand.smiles  \\\n",
-       "0  N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROX...          None   \n",
-       "1  1-[4-{[1-(3-{[dihydroxy(propyl)-lambda~4~-sulf...          None   \n",
+       "0  N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROX...          <NA>   \n",
+       "1  1-[4-{[1-(3-{[dihydroxy(propyl)-lambda~4~-sulf...          <NA>   \n",
        "\n",
        "  ligand.inchikey  kinase.klifs_id (query)  \n",
-       "0            None                      472  \n",
-       "1            None                      509  "
+       "0            <NA>                      472  \n",
+       "1            <NA>                      509  "
       ]
      },
      "execution_count": 42,
@@ -3165,18 +3222,10 @@
    "execution_count": 44,
    "metadata": {},
    "outputs": [
-    {
-     "name": "stderr",
-     "output_type": "stream",
-     "text": [
-      "INFO:opencadd.databases.klifs.remote:Fetch kinase KLIFS IDs for input kinase names...\n",
-      "INFO:opencadd.databases.klifs.remote:Fetch ligands based on these KLIFS IDs...\n"
-     ]
-    },
     {
      "data": {
       "application/vnd.jupyter.widget-view+json": {
-       "model_id": "87c1a6993fd94af795927f3cf7880ce4",
+       "model_id": "98bd8339663140a7865be50814f5490e",
        "version_major": 2,
        "version_minor": 0
       },
@@ -3191,9 +3240,9 @@
      "name": "stderr",
      "output_type": "stream",
      "text": [
-      "ERROR:opencadd.databases.klifs.core:There was (were) 1/4 failed request(s).\n",
+      "There was (were) 1/4 failed request(s).\n",
       "Show error messages (up to 5 messages only):\n",
-      "ERROR:opencadd.databases.klifs.core:Error for 574: Expected type to be dict for value [400, 'KLIFS error: The provided kinase ID(s) is/are invalid'] to unmarshal to a <class 'abc.Error'>.Was <class 'list'> instead.\n"
+      "Error for 574: Expected type to be dict for value [400, 'KLIFS error: The provided kinase ID(s) is/are invalid'] to unmarshal to a <class 'abc.Error'>.Was <class 'list'> instead.\n"
      ]
     },
     {
@@ -3347,13 +3396,6 @@
    "execution_count": 45,
    "metadata": {},
    "outputs": [
-    {
-     "name": "stderr",
-     "output_type": "stream",
-     "text": [
-      "INFO:opencadd.databases.klifs.remote:Fetch kinase KLIFS IDs for input kinase names...\n"
-     ]
-    },
     {
      "name": "stdout",
      "output_type": "stream",
@@ -3415,22 +3457,22 @@
        "  <tbody>\n",
        "    <tr>\n",
        "      <th>0</th>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>1N1</td>\n",
        "      <td>N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROX...</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>BMX</td>\n",
        "      <td>BMX</td>\n",
        "      <td>Human</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>1</th>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>PRC</td>\n",
        "      <td>N-[4-METHYL-3-[[4-(3-PYRIDINYL)-2-PYRIMIDINYL]...</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>ABL1</td>\n",
        "      <td>Abl1</td>\n",
        "      <td>Mouse</td>\n",
@@ -3440,17 +3482,17 @@
        "</div>"
       ],
       "text/plain": [
-       "  ligand.klifs_id ligand.expo_id  \\\n",
-       "0            None            1N1   \n",
-       "1            None            PRC   \n",
+       "   ligand.klifs_id ligand.expo_id  \\\n",
+       "0             <NA>            1N1   \n",
+       "1             <NA>            PRC   \n",
        "\n",
        "                                         ligand.name ligand.smiles  \\\n",
-       "0  N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROX...          None   \n",
-       "1  N-[4-METHYL-3-[[4-(3-PYRIDINYL)-2-PYRIMIDINYL]...          None   \n",
+       "0  N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROX...          <NA>   \n",
+       "1  N-[4-METHYL-3-[[4-(3-PYRIDINYL)-2-PYRIMIDINYL]...          <NA>   \n",
        "\n",
        "  ligand.inchikey kinase.klifs_name (query) kinase.gene_name (query)  \\\n",
-       "0            None                       BMX                      BMX   \n",
-       "1            None                      ABL1                     Abl1   \n",
+       "0            <NA>                       BMX                      BMX   \n",
+       "1            <NA>                      ABL1                     Abl1   \n",
        "\n",
        "  species.klifs (query)  \n",
        "0                 Human  \n",
@@ -3768,25 +3810,25 @@
        "  <tbody>\n",
        "    <tr>\n",
        "      <th>0</th>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>PRC</td>\n",
        "      <td>N-[4-METHYL-3-[[4-(3-PYRIDINYL)-2-PYRIMIDINYL]...</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "    </tr>\n",
        "  </tbody>\n",
        "</table>\n",
        "</div>"
       ],
       "text/plain": [
-       "  ligand.klifs_id ligand.expo_id  \\\n",
-       "0            None            PRC   \n",
+       "   ligand.klifs_id ligand.expo_id  \\\n",
+       "0             <NA>            PRC   \n",
        "\n",
        "                                         ligand.name ligand.smiles  \\\n",
-       "0  N-[4-METHYL-3-[[4-(3-PYRIDINYL)-2-PYRIMIDINYL]...          None   \n",
+       "0  N-[4-METHYL-3-[[4-(3-PYRIDINYL)-2-PYRIMIDINYL]...          <NA>   \n",
        "\n",
        "  ligand.inchikey  \n",
-       "0            None  "
+       "0            <NA>  "
       ]
      },
      "execution_count": 52,
@@ -3874,6 +3916,7 @@
        "      <th>species.klifs</th>\n",
        "      <th>kinase.klifs_id</th>\n",
        "      <th>kinase.klifs_name</th>\n",
+       "      <th>kinase.names</th>\n",
        "      <th>kinase.family</th>\n",
        "      <th>kinase.group</th>\n",
        "      <th>structure.pocket</th>\n",
@@ -3891,6 +3934,7 @@
        "      <th>structure.missing_atoms</th>\n",
        "      <th>structure.rmsd1</th>\n",
        "      <th>structure.rmsd2</th>\n",
+       "      <th>interaction.fingerprint</th>\n",
        "      <th>structure.front</th>\n",
        "      <th>structure.gate</th>\n",
        "      <th>structure.back</th>\n",
@@ -3910,6 +3954,7 @@
        "      <th>structure.grich_angle</th>\n",
        "      <th>structure.grich_rotation</th>\n",
        "      <th>structure.filepath</th>\n",
+       "      <th>structure.curation_flag</th>\n",
        "    </tr>\n",
        "  </thead>\n",
        "  <tbody>\n",
@@ -3922,15 +3967,16 @@
        "      <td>Human</td>\n",
        "      <td>1</td>\n",
        "      <td>AKT1</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>KLLGKGTFGKVILYAMKILHTLTENRVLQNSRPFLTALKYSCFVME...</td>\n",
        "      <td>CQW</td>\n",
        "      <td>-</td>\n",
        "      <td>2147</td>\n",
        "      <td>0</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>in</td>\n",
        "      <td>in</td>\n",
        "      <td>2.0</td>\n",
@@ -3939,6 +3985,7 @@
        "      <td>0</td>\n",
        "      <td>0.779</td>\n",
        "      <td>2.093</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>True</td>\n",
        "      <td>False</td>\n",
        "      <td>False</td>\n",
@@ -3954,10 +4001,11 @@
        "      <td>False</td>\n",
        "      <td>False</td>\n",
        "      <td>False</td>\n",
-       "      <td>17.9435</td>\n",
-       "      <td>58.2835</td>\n",
-       "      <td>52.7742</td>\n",
-       "      <td>None</td>\n",
+       "      <td>17.943501</td>\n",
+       "      <td>58.283501</td>\n",
+       "      <td>52.774200</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>False</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>1</th>\n",
@@ -3968,15 +4016,16 @@
        "      <td>Human</td>\n",
        "      <td>1</td>\n",
        "      <td>AKT1</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>KLLGKGTFGKVILYAMKILHTLTENRVLQNSRPFLTALKYSCFVME...</td>\n",
        "      <td>-</td>\n",
        "      <td>-</td>\n",
        "      <td>0</td>\n",
        "      <td>0</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>in</td>\n",
        "      <td>in</td>\n",
        "      <td>2.4</td>\n",
@@ -3985,6 +4034,7 @@
        "      <td>0</td>\n",
        "      <td>0.776</td>\n",
        "      <td>2.091</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>False</td>\n",
        "      <td>False</td>\n",
        "      <td>False</td>\n",
@@ -4000,10 +4050,11 @@
        "      <td>False</td>\n",
        "      <td>False</td>\n",
        "      <td>False</td>\n",
-       "      <td>17.9011</td>\n",
-       "      <td>59.5948</td>\n",
-       "      <td>60.8725</td>\n",
-       "      <td>None</td>\n",
+       "      <td>17.901100</td>\n",
+       "      <td>59.594799</td>\n",
+       "      <td>60.872501</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>False</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>...</th>\n",
@@ -4050,6 +4101,9 @@
        "      <td>...</td>\n",
        "      <td>...</td>\n",
        "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>12519</th>\n",
@@ -4060,15 +4114,16 @@
        "      <td>Human</td>\n",
        "      <td>1096</td>\n",
        "      <td>PI4KA</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>_PMQSAAKAPYLAAIFKVGDCRQDMLALQIIDLFVFPYRVVCGVIE...</td>\n",
        "      <td>E4S</td>\n",
        "      <td>-</td>\n",
        "      <td>2974</td>\n",
        "      <td>0</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>out-like</td>\n",
        "      <td>in</td>\n",
        "      <td>NaN</td>\n",
@@ -4077,6 +4132,7 @@
        "      <td>0</td>\n",
        "      <td>1.704</td>\n",
        "      <td>2.676</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>True</td>\n",
        "      <td>False</td>\n",
        "      <td>False</td>\n",
@@ -4092,10 +4148,11 @@
        "      <td>False</td>\n",
        "      <td>False</td>\n",
        "      <td>False</td>\n",
-       "      <td>18.3243</td>\n",
-       "      <td>58.9635</td>\n",
-       "      <td>131.1870</td>\n",
-       "      <td>None</td>\n",
+       "      <td>18.324301</td>\n",
+       "      <td>58.963501</td>\n",
+       "      <td>131.186996</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>False</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>12520</th>\n",
@@ -4106,15 +4163,16 @@
        "      <td>Human</td>\n",
        "      <td>1096</td>\n",
        "      <td>PI4KA</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>_PMQSAAKAPYLAAIFKVGDCRQDMLALQIIDLFVFPYRVVCGVIE...</td>\n",
        "      <td>E4S</td>\n",
        "      <td>-</td>\n",
        "      <td>2974</td>\n",
        "      <td>0</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>out-like</td>\n",
        "      <td>in</td>\n",
        "      <td>NaN</td>\n",
@@ -4123,6 +4181,7 @@
        "      <td>0</td>\n",
        "      <td>1.699</td>\n",
        "      <td>2.670</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>True</td>\n",
        "      <td>True</td>\n",
        "      <td>False</td>\n",
@@ -4138,14 +4197,15 @@
        "      <td>False</td>\n",
        "      <td>False</td>\n",
        "      <td>False</td>\n",
-       "      <td>18.1686</td>\n",
-       "      <td>58.6454</td>\n",
-       "      <td>136.5030</td>\n",
-       "      <td>None</td>\n",
+       "      <td>18.168600</td>\n",
+       "      <td>58.645401</td>\n",
+       "      <td>136.503006</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>False</td>\n",
        "    </tr>\n",
        "  </tbody>\n",
        "</table>\n",
-       "<p>12521 rows × 43 columns</p>\n",
+       "<p>12521 rows × 46 columns</p>\n",
        "</div>"
       ],
       "text/plain": [
@@ -4163,12 +4223,12 @@
        "12519               A         Human             1096             PI4KA   \n",
        "12520               E         Human             1096             PI4KA   \n",
        "\n",
-       "      kinase.family kinase.group  \\\n",
-       "0              None         None   \n",
-       "1              None         None   \n",
-       "...             ...          ...   \n",
-       "12519          None         None   \n",
-       "12520          None         None   \n",
+       "      kinase.names kinase.family kinase.group  \\\n",
+       "0             <NA>          <NA>         <NA>   \n",
+       "1             <NA>          <NA>         <NA>   \n",
+       "...            ...           ...          ...   \n",
+       "12519         <NA>          <NA>         <NA>   \n",
+       "12520         <NA>          <NA>         <NA>   \n",
        "\n",
        "                                        structure.pocket ligand.expo_id  \\\n",
        "0      KLLGKGTFGKVILYAMKILHTLTENRVLQNSRPFLTALKYSCFVME...            CQW   \n",
@@ -4185,11 +4245,11 @@
        "12520                         -             2974                           0   \n",
        "\n",
        "      ligand.name ligand_allosteric.name structure.dfg structure.ac_helix  \\\n",
-       "0            None                   None            in                 in   \n",
-       "1            None                   None            in                 in   \n",
+       "0            <NA>                   <NA>            in                 in   \n",
+       "1            <NA>                   <NA>            in                 in   \n",
        "...           ...                    ...           ...                ...   \n",
-       "12519        None                   None      out-like                 in   \n",
-       "12520        None                   None      out-like                 in   \n",
+       "12519        <NA>                   <NA>      out-like                 in   \n",
+       "12520        <NA>                   <NA>      out-like                 in   \n",
        "\n",
        "       structure.resolution  structure.qualityscore  \\\n",
        "0                       2.0                     8.0   \n",
@@ -4205,49 +4265,56 @@
        "12519                           2                        0            1.704   \n",
        "12520                           2                        0            1.699   \n",
        "\n",
-       "       structure.rmsd2  structure.front  structure.gate  structure.back  \\\n",
-       "0                2.093             True           False           False   \n",
-       "1                2.091            False           False           False   \n",
-       "...                ...              ...             ...             ...   \n",
-       "12519            2.676             True           False           False   \n",
-       "12520            2.670             True            True           False   \n",
-       "\n",
-       "       structure.fp_i  structure.fp_ii  structure.bp_i_a  structure.bp_i_b  \\\n",
-       "0               False            False             False             False   \n",
-       "1               False            False             False             False   \n",
-       "...               ...              ...               ...               ...   \n",
-       "12519           False            False             False              True   \n",
-       "12520           False            False              True              True   \n",
-       "\n",
-       "       structure.bp_ii_in  structure.bp_ii_a_in  structure.bp_ii_b_in  \\\n",
-       "0                   False                 False                 False   \n",
-       "1                   False                 False                 False   \n",
-       "...                   ...                   ...                   ...   \n",
-       "12519               False                 False                 False   \n",
-       "12520               False                 False                 False   \n",
-       "\n",
-       "       structure.bp_ii_out  structure.bp_ii_b  structure.bp_iii  \\\n",
-       "0                    False              False             False   \n",
-       "1                    False              False             False   \n",
-       "...                    ...                ...               ...   \n",
-       "12519                False              False             False   \n",
-       "12520                False              False             False   \n",
-       "\n",
-       "       structure.bp_iv  structure.bp_v  structure.grich_distance  \\\n",
-       "0                False           False                   17.9435   \n",
-       "1                False           False                   17.9011   \n",
-       "...                ...             ...                       ...   \n",
-       "12519            False           False                   18.3243   \n",
-       "12520            False           False                   18.1686   \n",
-       "\n",
-       "       structure.grich_angle  structure.grich_rotation structure.filepath  \n",
-       "0                    58.2835                   52.7742               None  \n",
-       "1                    59.5948                   60.8725               None  \n",
-       "...                      ...                       ...                ...  \n",
-       "12519                58.9635                  131.1870               None  \n",
-       "12520                58.6454                  136.5030               None  \n",
-       "\n",
-       "[12521 rows x 43 columns]"
+       "       structure.rmsd2 interaction.fingerprint  structure.front  \\\n",
+       "0                2.093                    <NA>             True   \n",
+       "1                2.091                    <NA>            False   \n",
+       "...                ...                     ...              ...   \n",
+       "12519            2.676                    <NA>             True   \n",
+       "12520            2.670                    <NA>             True   \n",
+       "\n",
+       "       structure.gate  structure.back  structure.fp_i  structure.fp_ii  \\\n",
+       "0               False           False           False            False   \n",
+       "1               False           False           False            False   \n",
+       "...               ...             ...             ...              ...   \n",
+       "12519           False           False           False            False   \n",
+       "12520            True           False           False            False   \n",
+       "\n",
+       "       structure.bp_i_a  structure.bp_i_b  structure.bp_ii_in  \\\n",
+       "0                 False             False               False   \n",
+       "1                 False             False               False   \n",
+       "...                 ...               ...                 ...   \n",
+       "12519             False              True               False   \n",
+       "12520              True              True               False   \n",
+       "\n",
+       "       structure.bp_ii_a_in  structure.bp_ii_b_in  structure.bp_ii_out  \\\n",
+       "0                     False                 False                False   \n",
+       "1                     False                 False                False   \n",
+       "...                     ...                   ...                  ...   \n",
+       "12519                 False                 False                False   \n",
+       "12520                 False                 False                False   \n",
+       "\n",
+       "       structure.bp_ii_b  structure.bp_iii  structure.bp_iv  structure.bp_v  \\\n",
+       "0                  False             False            False           False   \n",
+       "1                  False             False            False           False   \n",
+       "...                  ...               ...              ...             ...   \n",
+       "12519              False             False            False           False   \n",
+       "12520              False             False            False           False   \n",
+       "\n",
+       "       structure.grich_distance  structure.grich_angle  \\\n",
+       "0                     17.943501              58.283501   \n",
+       "1                     17.901100              59.594799   \n",
+       "...                         ...                    ...   \n",
+       "12519                 18.324301              58.963501   \n",
+       "12520                 18.168600              58.645401   \n",
+       "\n",
+       "       structure.grich_rotation structure.filepath  structure.curation_flag  \n",
+       "0                     52.774200               <NA>                    False  \n",
+       "1                     60.872501               <NA>                    False  \n",
+       "...                         ...                ...                      ...  \n",
+       "12519                131.186996               <NA>                    False  \n",
+       "12520                136.503006               <NA>                    False  \n",
+       "\n",
+       "[12521 rows x 46 columns]"
       ]
      },
      "execution_count": 54,
@@ -4301,6 +4368,7 @@
        "      <th>species.klifs</th>\n",
        "      <th>kinase.klifs_id</th>\n",
        "      <th>kinase.klifs_name</th>\n",
+       "      <th>kinase.names</th>\n",
        "      <th>kinase.family</th>\n",
        "      <th>kinase.group</th>\n",
        "      <th>structure.pocket</th>\n",
@@ -4318,6 +4386,7 @@
        "      <th>structure.missing_atoms</th>\n",
        "      <th>structure.rmsd1</th>\n",
        "      <th>structure.rmsd2</th>\n",
+       "      <th>interaction.fingerprint</th>\n",
        "      <th>structure.front</th>\n",
        "      <th>structure.gate</th>\n",
        "      <th>structure.back</th>\n",
@@ -4337,6 +4406,7 @@
        "      <th>structure.grich_angle</th>\n",
        "      <th>structure.grich_rotation</th>\n",
        "      <th>structure.filepath</th>\n",
+       "      <th>structure.curation_flag</th>\n",
        "    </tr>\n",
        "  </thead>\n",
        "  <tbody>\n",
@@ -4349,13 +4419,14 @@
        "      <td>Human</td>\n",
        "      <td>472</td>\n",
        "      <td>BMX</td>\n",
+       "      <td>['BMX']</td>\n",
        "      <td>Tec</td>\n",
        "      <td>TK</td>\n",
        "      <td>KELGS____VVKLVAVKMIEFFQEAQTMMKLSPKLVKFYGVYIVTE...</td>\n",
        "      <td>1N1</td>\n",
        "      <td>-</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROX...</td>\n",
        "      <td>-</td>\n",
        "      <td>out-like</td>\n",
@@ -4366,25 +4437,27 @@
        "      <td>0</td>\n",
        "      <td>0.839</td>\n",
        "      <td>1.967</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>1</td>\n",
-       "      <td>1</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>0000000000000010000001000000000000000000000000...</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>True</td>\n",
+       "      <td>True</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>NaN</td>\n",
        "      <td>HUMAN/BMX/3sxr_chainA</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>1</th>\n",
@@ -4395,13 +4468,14 @@
        "      <td>Human</td>\n",
        "      <td>509</td>\n",
        "      <td>BRAF</td>\n",
+       "      <td>['BRAF']</td>\n",
        "      <td>RAF</td>\n",
        "      <td>TKL</td>\n",
        "      <td>QRI____FGTVYKVAVKMLAFKNEVGVLRKTRVNILLFMGYAIVTQ...</td>\n",
        "      <td>QH1</td>\n",
        "      <td>-</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>1-[4-{[1-(3-{[dihydroxy(propyl)-lambda~4~-sulf...</td>\n",
        "      <td>-</td>\n",
        "      <td>in</td>\n",
@@ -4412,212 +4486,294 @@
        "      <td>61</td>\n",
        "      <td>0.806</td>\n",
        "      <td>2.028</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>1</td>\n",
-       "      <td>1</td>\n",
-       "      <td>1</td>\n",
-       "      <td>1</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>0000000000000000000000000000000000000000000000...</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>True</td>\n",
+       "      <td>True</td>\n",
+       "      <td>True</td>\n",
+       "      <td>True</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>NaN</td>\n",
        "      <td>HUMAN/BRAF/6uuo_chainA</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "    </tr>\n",
        "    <tr>\n",
-       "      <th>2</th>\n",
-       "      <td>5728</td>\n",
-       "      <td>1fpu</td>\n",
+       "      <th>...</th>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "    </tr>\n",
+       "    <tr>\n",
+       "      <th>4</th>\n",
+       "      <td>13623</td>\n",
+       "      <td>7lht</td>\n",
        "      <td>-</td>\n",
        "      <td>A</td>\n",
-       "      <td>Mouse</td>\n",
-       "      <td>532</td>\n",
-       "      <td>ABL1</td>\n",
-       "      <td>Abl</td>\n",
-       "      <td>TK</td>\n",
-       "      <td>HKLGGGQYGEVYEVAVKTLEFLKEAAVMKEIKPNLVQLLGVYIITE...</td>\n",
-       "      <td>PRC</td>\n",
+       "      <td>Human</td>\n",
+       "      <td>495</td>\n",
+       "      <td>LRRK2</td>\n",
+       "      <td>['LRRK2']</td>\n",
+       "      <td>LRRK</td>\n",
+       "      <td>TKL</td>\n",
+       "      <td>KALGKGLFSMVIRITLKVVGLRILNLPHLILEYCKAKDIIRFLQQK...</td>\n",
        "      <td>-</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>N-[4-METHYL-3-[[4-(3-PYRIDINYL)-2-PYRIMIDINYL]...</td>\n",
+       "      <td>ATP</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>-</td>\n",
+       "      <td>ADENOSINE-5&amp;apos;-TRIPHOSPHATE</td>\n",
        "      <td>out</td>\n",
        "      <td>out</td>\n",
-       "      <td>2.40</td>\n",
-       "      <td>8.8</td>\n",
-       "      <td>0</td>\n",
-       "      <td>8</td>\n",
-       "      <td>0.925</td>\n",
-       "      <td>2.319</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>1</td>\n",
-       "      <td>1</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>1</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
+       "      <td>3.50</td>\n",
+       "      <td>4.0</td>\n",
        "      <td>0</td>\n",
        "      <td>0</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>MOUSE/ABL1/1fpu_chainA</td>\n",
-       "    </tr>\n",
-       "    <tr>\n",
-       "      <th>3</th>\n",
-       "      <td>5705</td>\n",
-       "      <td>1fpu</td>\n",
-       "      <td>-</td>\n",
-       "      <td>B</td>\n",
-       "      <td>Mouse</td>\n",
-       "      <td>532</td>\n",
-       "      <td>ABL1</td>\n",
-       "      <td>Abl</td>\n",
-       "      <td>TK</td>\n",
-       "      <td>HKLGGGQYGEVYEVAVKTLEFLKEAAVMKEIKPNLVQLLGVYIITE...</td>\n",
-       "      <td>PRC</td>\n",
-       "      <td>-</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>N-[4-METHYL-3-[[4-(3-PYRIDINYL)-2-PYRIMIDINYL]...</td>\n",
+       "      <td>10.267</td>\n",
+       "      <td>15.045</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>HUMAN/LRRK2/7lht_chainA</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "    </tr>\n",
+       "    <tr>\n",
+       "      <th>5</th>\n",
+       "      <td>1243</td>\n",
+       "      <td>2ogv</td>\n",
+       "      <td>-</td>\n",
+       "      <td>A</td>\n",
+       "      <td>Human</td>\n",
+       "      <td>449</td>\n",
+       "      <td>FMS</td>\n",
+       "      <td>['CSF1R', 'FMS']</td>\n",
+       "      <td>PDGFR</td>\n",
+       "      <td>TK</td>\n",
+       "      <td>KTLGAGAFGKVVEVAVKMLALMSELKIMSHLGENIVNLLGALVITE...</td>\n",
+       "      <td>-</td>\n",
+       "      <td>-</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>-</td>\n",
        "      <td>-</td>\n",
        "      <td>out</td>\n",
-       "      <td>out</td>\n",
-       "      <td>2.40</td>\n",
-       "      <td>9.2</td>\n",
-       "      <td>0</td>\n",
-       "      <td>4</td>\n",
-       "      <td>0.925</td>\n",
-       "      <td>2.329</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>1</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>1</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
+       "      <td>in</td>\n",
+       "      <td>2.70</td>\n",
+       "      <td>6.4</td>\n",
+       "      <td>2</td>\n",
        "      <td>0</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>MOUSE/ABL1/1fpu_chainB</td>\n",
+       "      <td>1.043</td>\n",
+       "      <td>2.362</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>HUMAN/FMS/2ogv_chainA</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "    </tr>\n",
        "  </tbody>\n",
        "</table>\n",
+       "<p>6 rows × 46 columns</p>\n",
        "</div>"
       ],
       "text/plain": [
-       "   structure.klifs_id structure.pdb_id structure.alternate_model  \\\n",
-       "0                3482             3sxr                         -   \n",
-       "1               12347             6uuo                         -   \n",
-       "2                5728             1fpu                         -   \n",
-       "3                5705             1fpu                         -   \n",
+       "    structure.klifs_id structure.pdb_id structure.alternate_model  \\\n",
+       "0                 3482             3sxr                         -   \n",
+       "1                12347             6uuo                         -   \n",
+       "..                 ...              ...                       ...   \n",
+       "4                13623             7lht                         -   \n",
+       "5                 1243             2ogv                         -   \n",
        "\n",
-       "  structure.chain species.klifs  kinase.klifs_id kinase.klifs_name  \\\n",
-       "0               A         Human              472               BMX   \n",
-       "1               A         Human              509              BRAF   \n",
-       "2               A         Mouse              532              ABL1   \n",
-       "3               B         Mouse              532              ABL1   \n",
+       "   structure.chain species.klifs  kinase.klifs_id kinase.klifs_name  \\\n",
+       "0                A         Human              472               BMX   \n",
+       "1                A         Human              509              BRAF   \n",
+       "..             ...           ...              ...               ...   \n",
+       "4                A         Human              495             LRRK2   \n",
+       "5                A         Human              449               FMS   \n",
        "\n",
-       "  kinase.family kinase.group  \\\n",
-       "0           Tec           TK   \n",
-       "1           RAF          TKL   \n",
-       "2           Abl           TK   \n",
-       "3           Abl           TK   \n",
+       "        kinase.names kinase.family kinase.group  \\\n",
+       "0            ['BMX']           Tec           TK   \n",
+       "1           ['BRAF']           RAF          TKL   \n",
+       "..               ...           ...          ...   \n",
+       "4          ['LRRK2']          LRRK          TKL   \n",
+       "5   ['CSF1R', 'FMS']         PDGFR           TK   \n",
        "\n",
-       "                                    structure.pocket ligand.expo_id  \\\n",
-       "0  KELGS____VVKLVAVKMIEFFQEAQTMMKLSPKLVKFYGVYIVTE...            1N1   \n",
-       "1  QRI____FGTVYKVAVKMLAFKNEVGVLRKTRVNILLFMGYAIVTQ...            QH1   \n",
-       "2  HKLGGGQYGEVYEVAVKTLEFLKEAAVMKEIKPNLVQLLGVYIITE...            PRC   \n",
-       "3  HKLGGGQYGEVYEVAVKTLEFLKEAAVMKEIKPNLVQLLGVYIITE...            PRC   \n",
+       "                                     structure.pocket ligand.expo_id  \\\n",
+       "0   KELGS____VVKLVAVKMIEFFQEAQTMMKLSPKLVKFYGVYIVTE...            1N1   \n",
+       "1   QRI____FGTVYKVAVKMLAFKNEVGVLRKTRVNILLFMGYAIVTQ...            QH1   \n",
+       "..                                                ...            ...   \n",
+       "4   KALGKGLFSMVIRITLKVVGLRILNLPHLILEYCKAKDIIRFLQQK...              -   \n",
+       "5   KTLGAGAFGKVVEVAVKMLALMSELKIMSHLGENIVNLLGALVITE...              -   \n",
        "\n",
-       "  ligand_allosteric.expo_id ligand.klifs_id ligand_allosteric.klifs_id  \\\n",
-       "0                         -            None                       None   \n",
-       "1                         -            None                       None   \n",
-       "2                         -            None                       None   \n",
-       "3                         -            None                       None   \n",
+       "   ligand_allosteric.expo_id  ligand.klifs_id  ligand_allosteric.klifs_id  \\\n",
+       "0                          -             <NA>                        <NA>   \n",
+       "1                          -             <NA>                        <NA>   \n",
+       "..                       ...              ...                         ...   \n",
+       "4                        ATP             <NA>                        <NA>   \n",
+       "5                          -             <NA>                        <NA>   \n",
        "\n",
-       "                                         ligand.name ligand_allosteric.name  \\\n",
-       "0  N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROX...                      -   \n",
-       "1  1-[4-{[1-(3-{[dihydroxy(propyl)-lambda~4~-sulf...                      -   \n",
-       "2  N-[4-METHYL-3-[[4-(3-PYRIDINYL)-2-PYRIMIDINYL]...                      -   \n",
-       "3  N-[4-METHYL-3-[[4-(3-PYRIDINYL)-2-PYRIMIDINYL]...                      -   \n",
+       "                                          ligand.name  \\\n",
+       "0   N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROX...   \n",
+       "1   1-[4-{[1-(3-{[dihydroxy(propyl)-lambda~4~-sulf...   \n",
+       "..                                                ...   \n",
+       "4                                                   -   \n",
+       "5                                                   -   \n",
        "\n",
-       "  structure.dfg structure.ac_helix  structure.resolution  \\\n",
-       "0      out-like                 in                  2.40   \n",
-       "1            in           out-like                  3.29   \n",
-       "2           out                out                  2.40   \n",
-       "3           out                out                  2.40   \n",
+       "            ligand_allosteric.name structure.dfg structure.ac_helix  \\\n",
+       "0                                -      out-like                 in   \n",
+       "1                                -            in           out-like   \n",
+       "..                             ...           ...                ...   \n",
+       "4   ADENOSINE-5&apos;-TRIPHOSPHATE           out                out   \n",
+       "5                                -           out                 in   \n",
        "\n",
-       "   structure.qualityscore  structure.missing_residues  \\\n",
-       "0                     6.4                           4   \n",
-       "1                     5.2                           7   \n",
-       "2                     8.8                           0   \n",
-       "3                     9.2                           0   \n",
+       "    structure.resolution  structure.qualityscore  structure.missing_residues  \\\n",
+       "0                   2.40                     6.4                           4   \n",
+       "1                   3.29                     5.2                           7   \n",
+       "..                   ...                     ...                         ...   \n",
+       "4                   3.50                     4.0                           0   \n",
+       "5                   2.70                     6.4                           2   \n",
        "\n",
-       "   structure.missing_atoms  structure.rmsd1  structure.rmsd2 structure.front  \\\n",
-       "0                        0            0.839            1.967            None   \n",
-       "1                       61            0.806            2.028            None   \n",
-       "2                        8            0.925            2.319            None   \n",
-       "3                        4            0.925            2.329            None   \n",
+       "    structure.missing_atoms  structure.rmsd1  structure.rmsd2  \\\n",
+       "0                         0            0.839            1.967   \n",
+       "1                        61            0.806            2.028   \n",
+       "..                      ...              ...              ...   \n",
+       "4                         0           10.267           15.045   \n",
+       "5                         0            1.043            2.362   \n",
+       "\n",
+       "                              interaction.fingerprint  structure.front  \\\n",
+       "0   0000000000000010000001000000000000000000000000...             <NA>   \n",
+       "1   0000000000000000000000000000000000000000000000...             <NA>   \n",
+       "..                                                ...              ...   \n",
+       "4                                                <NA>             <NA>   \n",
+       "5                                                <NA>             <NA>   \n",
+       "\n",
+       "    structure.gate  structure.back  structure.fp_i  structure.fp_ii  \\\n",
+       "0             <NA>            <NA>           False            False   \n",
+       "1             <NA>            <NA>           False            False   \n",
+       "..             ...             ...             ...              ...   \n",
+       "4             <NA>            <NA>            <NA>             <NA>   \n",
+       "5             <NA>            <NA>            <NA>             <NA>   \n",
+       "\n",
+       "    structure.bp_i_a  structure.bp_i_b  structure.bp_ii_in  \\\n",
+       "0               True              True               False   \n",
+       "1               True              True                True   \n",
+       "..               ...               ...                 ...   \n",
+       "4               <NA>              <NA>                <NA>   \n",
+       "5               <NA>              <NA>                <NA>   \n",
+       "\n",
+       "    structure.bp_ii_a_in  structure.bp_ii_b_in  structure.bp_ii_out  \\\n",
+       "0                  False                 False                False   \n",
+       "1                   True                 False                False   \n",
+       "..                   ...                   ...                  ...   \n",
+       "4                   <NA>                  <NA>                 <NA>   \n",
+       "5                   <NA>                  <NA>                 <NA>   \n",
        "\n",
-       "  structure.gate structure.back  structure.fp_i  structure.fp_ii  \\\n",
-       "0           None           None               0                0   \n",
-       "1           None           None               0                0   \n",
-       "2           None           None               0                0   \n",
-       "3           None           None               0                0   \n",
+       "    structure.bp_ii_b  structure.bp_iii  structure.bp_iv  structure.bp_v  \\\n",
+       "0               False             False            False           False   \n",
+       "1               False             False            False           False   \n",
+       "..                ...               ...              ...             ...   \n",
+       "4                <NA>              <NA>             <NA>            <NA>   \n",
+       "5                <NA>              <NA>             <NA>            <NA>   \n",
        "\n",
-       "   structure.bp_i_a  structure.bp_i_b  structure.bp_ii_in  \\\n",
-       "0                 1                 1                   0   \n",
-       "1                 1                 1                   1   \n",
-       "2                 1                 1                   0   \n",
-       "3                 0                 1                   0   \n",
+       "    structure.grich_distance  structure.grich_angle  structure.grich_rotation  \\\n",
+       "0                        NaN                    NaN                       NaN   \n",
+       "1                        NaN                    NaN                       NaN   \n",
+       "..                       ...                    ...                       ...   \n",
+       "4                        NaN                    NaN                       NaN   \n",
+       "5                        NaN                    NaN                       NaN   \n",
        "\n",
-       "   structure.bp_ii_a_in  structure.bp_ii_b_in  structure.bp_ii_out  \\\n",
-       "0                     0                     0                    0   \n",
-       "1                     1                     0                    0   \n",
-       "2                     0                     0                    1   \n",
-       "3                     0                     0                    1   \n",
+       "         structure.filepath  structure.curation_flag  \n",
+       "0     HUMAN/BMX/3sxr_chainA                     <NA>  \n",
+       "1    HUMAN/BRAF/6uuo_chainA                     <NA>  \n",
+       "..                      ...                      ...  \n",
+       "4   HUMAN/LRRK2/7lht_chainA                     <NA>  \n",
+       "5     HUMAN/FMS/2ogv_chainA                     <NA>  \n",
        "\n",
-       "   structure.bp_ii_b  structure.bp_iii  structure.bp_iv  structure.bp_v  \\\n",
-       "0                  0                 0                0               0   \n",
-       "1                  0                 0                0               0   \n",
-       "2                  0                 0                0               0   \n",
-       "3                  0                 0                0               0   \n",
-       "\n",
-       "  structure.grich_distance structure.grich_angle structure.grich_rotation  \\\n",
-       "0                     None                  None                     None   \n",
-       "1                     None                  None                     None   \n",
-       "2                     None                  None                     None   \n",
-       "3                     None                  None                     None   \n",
-       "\n",
-       "       structure.filepath  \n",
-       "0   HUMAN/BMX/3sxr_chainA  \n",
-       "1  HUMAN/BRAF/6uuo_chainA  \n",
-       "2  MOUSE/ABL1/1fpu_chainA  \n",
-       "3  MOUSE/ABL1/1fpu_chainB  "
+       "[6 rows x 46 columns]"
       ]
      },
      "execution_count": 55,
@@ -4676,6 +4832,7 @@
        "      <th>species.klifs</th>\n",
        "      <th>kinase.klifs_id</th>\n",
        "      <th>kinase.klifs_name</th>\n",
+       "      <th>kinase.names</th>\n",
        "      <th>kinase.family</th>\n",
        "      <th>kinase.group</th>\n",
        "      <th>structure.pocket</th>\n",
@@ -4693,6 +4850,7 @@
        "      <th>structure.missing_atoms</th>\n",
        "      <th>structure.rmsd1</th>\n",
        "      <th>structure.rmsd2</th>\n",
+       "      <th>interaction.fingerprint</th>\n",
        "      <th>structure.front</th>\n",
        "      <th>structure.gate</th>\n",
        "      <th>structure.back</th>\n",
@@ -4712,6 +4870,7 @@
        "      <th>structure.grich_angle</th>\n",
        "      <th>structure.grich_rotation</th>\n",
        "      <th>structure.filepath</th>\n",
+       "      <th>structure.curation_flag</th>\n",
        "    </tr>\n",
        "  </thead>\n",
        "  <tbody>\n",
@@ -4724,15 +4883,16 @@
        "      <td>Human</td>\n",
        "      <td>509</td>\n",
        "      <td>BRAF</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>QRI____FGTVYKVAVKMLAFKNEVGVLRKTRVNILLFMGYAIVTQ...</td>\n",
        "      <td>QH1</td>\n",
        "      <td>-</td>\n",
        "      <td>3715</td>\n",
        "      <td>0</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>in</td>\n",
        "      <td>out</td>\n",
        "      <td>3.29</td>\n",
@@ -4741,6 +4901,7 @@
        "      <td>61</td>\n",
        "      <td>0.806</td>\n",
        "      <td>2.028</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>True</td>\n",
        "      <td>True</td>\n",
        "      <td>True</td>\n",
@@ -4759,7 +4920,8 @@
        "      <td>0.0</td>\n",
        "      <td>0.0</td>\n",
        "      <td>0.0</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>False</td>\n",
        "    </tr>\n",
        "  </tbody>\n",
        "</table>\n",
@@ -4772,8 +4934,8 @@
        "  structure.chain species.klifs  kinase.klifs_id kinase.klifs_name  \\\n",
        "0               A         Human              509              BRAF   \n",
        "\n",
-       "  kinase.family kinase.group  \\\n",
-       "0          None         None   \n",
+       "  kinase.names kinase.family kinase.group  \\\n",
+       "0         <NA>          <NA>         <NA>   \n",
        "\n",
        "                                    structure.pocket ligand.expo_id  \\\n",
        "0  QRI____FGTVYKVAVKMLAFKNEVGVLRKTRVNILLFMGYAIVTQ...            QH1   \n",
@@ -4782,31 +4944,31 @@
        "0                         -             3715                           0   \n",
        "\n",
        "  ligand.name ligand_allosteric.name structure.dfg structure.ac_helix  \\\n",
-       "0        None                   None            in                out   \n",
+       "0        <NA>                   <NA>            in                out   \n",
        "\n",
        "   structure.resolution  structure.qualityscore  structure.missing_residues  \\\n",
        "0                  3.29                     5.2                           7   \n",
        "\n",
-       "   structure.missing_atoms  structure.rmsd1  structure.rmsd2  structure.front  \\\n",
-       "0                       61            0.806            2.028             True   \n",
+       "   structure.missing_atoms  structure.rmsd1  structure.rmsd2  \\\n",
+       "0                       61            0.806            2.028   \n",
        "\n",
-       "   structure.gate  structure.back  structure.fp_i  structure.fp_ii  \\\n",
-       "0            True            True           False            False   \n",
+       "  interaction.fingerprint  structure.front  structure.gate  structure.back  \\\n",
+       "0                    <NA>             True            True            True   \n",
        "\n",
-       "   structure.bp_i_a  structure.bp_i_b  structure.bp_ii_in  \\\n",
-       "0              True              True                True   \n",
+       "   structure.fp_i  structure.fp_ii  structure.bp_i_a  structure.bp_i_b  \\\n",
+       "0           False            False              True              True   \n",
        "\n",
-       "   structure.bp_ii_a_in  structure.bp_ii_b_in  structure.bp_ii_out  \\\n",
-       "0                  True                 False                False   \n",
+       "   structure.bp_ii_in  structure.bp_ii_a_in  structure.bp_ii_b_in  \\\n",
+       "0                True                  True                 False   \n",
        "\n",
-       "   structure.bp_ii_b  structure.bp_iii  structure.bp_iv  structure.bp_v  \\\n",
-       "0              False             False            False           False   \n",
+       "   structure.bp_ii_out  structure.bp_ii_b  structure.bp_iii  structure.bp_iv  \\\n",
+       "0                False              False             False            False   \n",
        "\n",
-       "   structure.grich_distance  structure.grich_angle  structure.grich_rotation  \\\n",
-       "0                       0.0                    0.0                       0.0   \n",
+       "   structure.bp_v  structure.grich_distance  structure.grich_angle  \\\n",
+       "0           False                       0.0                    0.0   \n",
        "\n",
-       "  structure.filepath  \n",
-       "0               None  "
+       "   structure.grich_rotation structure.filepath  structure.curation_flag  \n",
+       "0                       0.0               <NA>                    False  "
       ]
      },
      "execution_count": 56,
@@ -4878,6 +5040,7 @@
        "      <th>species.klifs</th>\n",
        "      <th>kinase.klifs_id</th>\n",
        "      <th>kinase.klifs_name</th>\n",
+       "      <th>kinase.names</th>\n",
        "      <th>kinase.family</th>\n",
        "      <th>kinase.group</th>\n",
        "      <th>structure.pocket</th>\n",
@@ -4895,6 +5058,7 @@
        "      <th>structure.missing_atoms</th>\n",
        "      <th>structure.rmsd1</th>\n",
        "      <th>structure.rmsd2</th>\n",
+       "      <th>interaction.fingerprint</th>\n",
        "      <th>structure.front</th>\n",
        "      <th>structure.gate</th>\n",
        "      <th>structure.back</th>\n",
@@ -4914,6 +5078,7 @@
        "      <th>structure.grich_angle</th>\n",
        "      <th>structure.grich_rotation</th>\n",
        "      <th>structure.filepath</th>\n",
+       "      <th>structure.curation_flag</th>\n",
        "    </tr>\n",
        "  </thead>\n",
        "  <tbody>\n",
@@ -4926,13 +5091,14 @@
        "      <td>Human</td>\n",
        "      <td>509</td>\n",
        "      <td>BRAF</td>\n",
+       "      <td>['BRAF']</td>\n",
        "      <td>RAF</td>\n",
        "      <td>TKL</td>\n",
        "      <td>QRI____FGTVYKVAVKMLAFKNEVGVLRKTRVNILLFMGYAIVTQ...</td>\n",
        "      <td>QH1</td>\n",
        "      <td>-</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>1-[4-{[1-(3-{[dihydroxy(propyl)-lambda~4~-sulf...</td>\n",
        "      <td>-</td>\n",
        "      <td>in</td>\n",
@@ -4943,25 +5109,27 @@
        "      <td>61</td>\n",
        "      <td>0.806</td>\n",
        "      <td>2.028</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>1</td>\n",
-       "      <td>1</td>\n",
-       "      <td>1</td>\n",
-       "      <td>1</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>0000000000000000000000000000000000000000000000...</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>True</td>\n",
+       "      <td>True</td>\n",
+       "      <td>True</td>\n",
+       "      <td>True</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>NaN</td>\n",
        "      <td>HUMAN/BRAF/6uuo_chainA</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "    </tr>\n",
        "  </tbody>\n",
        "</table>\n",
@@ -4974,14 +5142,14 @@
        "  structure.chain species.klifs  kinase.klifs_id kinase.klifs_name  \\\n",
        "0               A         Human              509              BRAF   \n",
        "\n",
-       "  kinase.family kinase.group  \\\n",
-       "0           RAF          TKL   \n",
+       "  kinase.names kinase.family kinase.group  \\\n",
+       "0     ['BRAF']           RAF          TKL   \n",
        "\n",
        "                                    structure.pocket ligand.expo_id  \\\n",
        "0  QRI____FGTVYKVAVKMLAFKNEVGVLRKTRVNILLFMGYAIVTQ...            QH1   \n",
        "\n",
-       "  ligand_allosteric.expo_id ligand.klifs_id ligand_allosteric.klifs_id  \\\n",
-       "0                         -            None                       None   \n",
+       "  ligand_allosteric.expo_id  ligand.klifs_id  ligand_allosteric.klifs_id  \\\n",
+       "0                         -             <NA>                        <NA>   \n",
        "\n",
        "                                         ligand.name ligand_allosteric.name  \\\n",
        "0  1-[4-{[1-(3-{[dihydroxy(propyl)-lambda~4~-sulf...                      -   \n",
@@ -4992,26 +5160,29 @@
        "   structure.qualityscore  structure.missing_residues  \\\n",
        "0                     5.2                           7   \n",
        "\n",
-       "   structure.missing_atoms  structure.rmsd1  structure.rmsd2 structure.front  \\\n",
-       "0                       61            0.806            2.028            None   \n",
+       "   structure.missing_atoms  structure.rmsd1  structure.rmsd2  \\\n",
+       "0                       61            0.806            2.028   \n",
        "\n",
-       "  structure.gate structure.back  structure.fp_i  structure.fp_ii  \\\n",
-       "0           None           None               0                0   \n",
+       "                             interaction.fingerprint  structure.front  \\\n",
+       "0  0000000000000000000000000000000000000000000000...             <NA>   \n",
+       "\n",
+       "   structure.gate  structure.back  structure.fp_i  structure.fp_ii  \\\n",
+       "0            <NA>            <NA>           False            False   \n",
        "\n",
        "   structure.bp_i_a  structure.bp_i_b  structure.bp_ii_in  \\\n",
-       "0                 1                 1                   1   \n",
+       "0              True              True                True   \n",
        "\n",
        "   structure.bp_ii_a_in  structure.bp_ii_b_in  structure.bp_ii_out  \\\n",
-       "0                     1                     0                    0   \n",
+       "0                  True                 False                False   \n",
        "\n",
        "   structure.bp_ii_b  structure.bp_iii  structure.bp_iv  structure.bp_v  \\\n",
-       "0                  0                 0                0               0   \n",
+       "0              False             False            False           False   \n",
        "\n",
-       "  structure.grich_distance structure.grich_angle structure.grich_rotation  \\\n",
-       "0                     None                  None                     None   \n",
+       "   structure.grich_distance  structure.grich_angle  structure.grich_rotation  \\\n",
+       "0                       NaN                    NaN                       NaN   \n",
        "\n",
-       "       structure.filepath  \n",
-       "0  HUMAN/BRAF/6uuo_chainA  "
+       "       structure.filepath  structure.curation_flag  \n",
+       "0  HUMAN/BRAF/6uuo_chainA                     <NA>  "
       ]
      },
      "execution_count": 58,
@@ -5031,7 +5202,7 @@
     {
      "data": {
       "text/plain": [
-       "(1, 43)"
+       "(1, 46)"
       ]
      },
      "execution_count": 59,
@@ -5110,6 +5281,7 @@
        "      <th>species.klifs</th>\n",
        "      <th>kinase.klifs_id</th>\n",
        "      <th>kinase.klifs_name</th>\n",
+       "      <th>kinase.names</th>\n",
        "      <th>kinase.family</th>\n",
        "      <th>kinase.group</th>\n",
        "      <th>structure.pocket</th>\n",
@@ -5127,6 +5299,7 @@
        "      <th>structure.missing_atoms</th>\n",
        "      <th>structure.rmsd1</th>\n",
        "      <th>structure.rmsd2</th>\n",
+       "      <th>interaction.fingerprint</th>\n",
        "      <th>structure.front</th>\n",
        "      <th>structure.gate</th>\n",
        "      <th>structure.back</th>\n",
@@ -5146,6 +5319,7 @@
        "      <th>structure.grich_angle</th>\n",
        "      <th>structure.grich_rotation</th>\n",
        "      <th>structure.filepath</th>\n",
+       "      <th>structure.curation_flag</th>\n",
        "    </tr>\n",
        "  </thead>\n",
        "  <tbody>\n",
@@ -5158,15 +5332,16 @@
        "      <td>Human</td>\n",
        "      <td>128</td>\n",
        "      <td>MELK</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>ETIGTGGFAKVKLVAIKIMRIKTEIEALKNLRQHICQLYHVFMVLE...</td>\n",
        "      <td>KSA</td>\n",
        "      <td>-</td>\n",
        "      <td>100</td>\n",
        "      <td>0</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>in</td>\n",
        "      <td>in</td>\n",
        "      <td>1.9</td>\n",
@@ -5175,6 +5350,7 @@
        "      <td>0</td>\n",
        "      <td>0.775</td>\n",
        "      <td>2.083</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>True</td>\n",
        "      <td>False</td>\n",
        "      <td>False</td>\n",
@@ -5191,9 +5367,10 @@
        "      <td>False</td>\n",
        "      <td>False</td>\n",
        "      <td>14.9753</td>\n",
-       "      <td>51.0238</td>\n",
-       "      <td>60.3786</td>\n",
-       "      <td>None</td>\n",
+       "      <td>51.023800</td>\n",
+       "      <td>60.378601</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>False</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>1</th>\n",
@@ -5204,15 +5381,16 @@
        "      <td>Human</td>\n",
        "      <td>128</td>\n",
        "      <td>MELK</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>ETIGTGGFAKVKLVAIKIMRIKTEIEALKNLRQHICQLYHVFMVLE...</td>\n",
        "      <td>KSA</td>\n",
        "      <td>-</td>\n",
        "      <td>100</td>\n",
        "      <td>0</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>in</td>\n",
        "      <td>in</td>\n",
        "      <td>1.9</td>\n",
@@ -5221,6 +5399,7 @@
        "      <td>0</td>\n",
        "      <td>0.775</td>\n",
        "      <td>2.083</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>True</td>\n",
        "      <td>False</td>\n",
        "      <td>False</td>\n",
@@ -5237,9 +5416,10 @@
        "      <td>False</td>\n",
        "      <td>False</td>\n",
        "      <td>14.9753</td>\n",
-       "      <td>51.0238</td>\n",
-       "      <td>60.3786</td>\n",
-       "      <td>None</td>\n",
+       "      <td>51.023800</td>\n",
+       "      <td>60.378601</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>False</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>...</th>\n",
@@ -5286,6 +5466,9 @@
        "      <td>...</td>\n",
        "      <td>...</td>\n",
        "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>12</th>\n",
@@ -5296,15 +5479,16 @@
        "      <td>Human</td>\n",
        "      <td>383</td>\n",
        "      <td>MAP2K1</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>SELGAGNGGVVFKMARKLIQIIRELQVLHECNPYIVGFYGASICME...</td>\n",
        "      <td>KSA</td>\n",
        "      <td>-</td>\n",
        "      <td>100</td>\n",
        "      <td>0</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>in</td>\n",
        "      <td>out</td>\n",
        "      <td>2.7</td>\n",
@@ -5313,6 +5497,7 @@
        "      <td>0</td>\n",
        "      <td>0.816</td>\n",
        "      <td>2.199</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>True</td>\n",
        "      <td>False</td>\n",
        "      <td>False</td>\n",
@@ -5329,9 +5514,10 @@
        "      <td>False</td>\n",
        "      <td>False</td>\n",
        "      <td>15.1080</td>\n",
-       "      <td>51.2885</td>\n",
-       "      <td>69.3669</td>\n",
-       "      <td>None</td>\n",
+       "      <td>51.288502</td>\n",
+       "      <td>69.366898</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>False</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>13</th>\n",
@@ -5342,15 +5528,16 @@
        "      <td>Human</td>\n",
        "      <td>446</td>\n",
        "      <td>MET</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>EVIGRGHFGCVYHCAVKSLQFLTEGIIMKDFSPNVLSLLGILVVLP...</td>\n",
        "      <td>KSA</td>\n",
        "      <td>-</td>\n",
        "      <td>100</td>\n",
        "      <td>0</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>in</td>\n",
        "      <td>out</td>\n",
        "      <td>1.8</td>\n",
@@ -5359,6 +5546,7 @@
        "      <td>0</td>\n",
        "      <td>0.848</td>\n",
        "      <td>2.189</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>True</td>\n",
        "      <td>False</td>\n",
        "      <td>False</td>\n",
@@ -5375,13 +5563,14 @@
        "      <td>False</td>\n",
        "      <td>False</td>\n",
        "      <td>20.0054</td>\n",
-       "      <td>66.3494</td>\n",
-       "      <td>48.1602</td>\n",
-       "      <td>None</td>\n",
+       "      <td>66.349403</td>\n",
+       "      <td>48.160198</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>False</td>\n",
        "    </tr>\n",
        "  </tbody>\n",
        "</table>\n",
-       "<p>14 rows × 43 columns</p>\n",
+       "<p>14 rows × 46 columns</p>\n",
        "</div>"
       ],
       "text/plain": [
@@ -5399,12 +5588,12 @@
        "12               A         Human              383            MAP2K1   \n",
        "13               A         Human              446               MET   \n",
        "\n",
-       "   kinase.family kinase.group  \\\n",
-       "0           None         None   \n",
-       "1           None         None   \n",
-       "..           ...          ...   \n",
-       "12          None         None   \n",
-       "13          None         None   \n",
+       "   kinase.names kinase.family kinase.group  \\\n",
+       "0          <NA>          <NA>         <NA>   \n",
+       "1          <NA>          <NA>         <NA>   \n",
+       "..          ...           ...          ...   \n",
+       "12         <NA>          <NA>         <NA>   \n",
+       "13         <NA>          <NA>         <NA>   \n",
        "\n",
        "                                     structure.pocket ligand.expo_id  \\\n",
        "0   ETIGTGGFAKVKLVAIKIMRIKTEIEALKNLRQHICQLYHVFMVLE...            KSA   \n",
@@ -5421,11 +5610,11 @@
        "13                         -              100                           0   \n",
        "\n",
        "   ligand.name ligand_allosteric.name structure.dfg structure.ac_helix  \\\n",
-       "0         None                   None            in                 in   \n",
-       "1         None                   None            in                 in   \n",
+       "0         <NA>                   <NA>            in                 in   \n",
+       "1         <NA>                   <NA>            in                 in   \n",
        "..         ...                    ...           ...                ...   \n",
-       "12        None                   None            in                out   \n",
-       "13        None                   None            in                out   \n",
+       "12        <NA>                   <NA>            in                out   \n",
+       "13        <NA>                   <NA>            in                out   \n",
        "\n",
        "    structure.resolution  structure.qualityscore  structure.missing_residues  \\\n",
        "0                    1.9                     8.0                           0   \n",
@@ -5441,49 +5630,49 @@
        "12                        0            0.816            2.199   \n",
        "13                        0            0.848            2.189   \n",
        "\n",
-       "    structure.front  structure.gate  structure.back  structure.fp_i  \\\n",
-       "0              True           False           False           False   \n",
-       "1              True           False           False           False   \n",
-       "..              ...             ...             ...             ...   \n",
-       "12             True           False           False           False   \n",
-       "13             True           False           False           False   \n",
-       "\n",
-       "    structure.fp_ii  structure.bp_i_a  structure.bp_i_b  structure.bp_ii_in  \\\n",
-       "0             False             False             False               False   \n",
-       "1             False             False             False               False   \n",
-       "..              ...               ...               ...                 ...   \n",
-       "12            False             False             False               False   \n",
-       "13             True             False             False               False   \n",
-       "\n",
-       "    structure.bp_ii_a_in  structure.bp_ii_b_in  structure.bp_ii_out  \\\n",
-       "0                  False                 False                False   \n",
-       "1                  False                 False                False   \n",
-       "..                   ...                   ...                  ...   \n",
-       "12                 False                 False                False   \n",
-       "13                 False                 False                False   \n",
-       "\n",
-       "    structure.bp_ii_b  structure.bp_iii  structure.bp_iv  structure.bp_v  \\\n",
-       "0               False             False            False           False   \n",
-       "1               False             False            False           False   \n",
-       "..                ...               ...              ...             ...   \n",
-       "12              False             False            False           False   \n",
-       "13              False             False            False           False   \n",
-       "\n",
-       "    structure.grich_distance  structure.grich_angle  structure.grich_rotation  \\\n",
-       "0                    14.9753                51.0238                   60.3786   \n",
-       "1                    14.9753                51.0238                   60.3786   \n",
-       "..                       ...                    ...                       ...   \n",
-       "12                   15.1080                51.2885                   69.3669   \n",
-       "13                   20.0054                66.3494                   48.1602   \n",
-       "\n",
-       "   structure.filepath  \n",
-       "0                None  \n",
-       "1                None  \n",
-       "..                ...  \n",
-       "12               None  \n",
-       "13               None  \n",
-       "\n",
-       "[14 rows x 43 columns]"
+       "   interaction.fingerprint  structure.front  structure.gate  structure.back  \\\n",
+       "0                     <NA>             True           False           False   \n",
+       "1                     <NA>             True           False           False   \n",
+       "..                     ...              ...             ...             ...   \n",
+       "12                    <NA>             True           False           False   \n",
+       "13                    <NA>             True           False           False   \n",
+       "\n",
+       "    structure.fp_i  structure.fp_ii  structure.bp_i_a  structure.bp_i_b  \\\n",
+       "0            False            False             False             False   \n",
+       "1            False            False             False             False   \n",
+       "..             ...              ...               ...               ...   \n",
+       "12           False            False             False             False   \n",
+       "13           False             True             False             False   \n",
+       "\n",
+       "    structure.bp_ii_in  structure.bp_ii_a_in  structure.bp_ii_b_in  \\\n",
+       "0                False                 False                 False   \n",
+       "1                False                 False                 False   \n",
+       "..                 ...                   ...                   ...   \n",
+       "12               False                 False                 False   \n",
+       "13               False                 False                 False   \n",
+       "\n",
+       "    structure.bp_ii_out  structure.bp_ii_b  structure.bp_iii  structure.bp_iv  \\\n",
+       "0                 False              False             False            False   \n",
+       "1                 False              False             False            False   \n",
+       "..                  ...                ...               ...              ...   \n",
+       "12                False              False             False            False   \n",
+       "13                False              False             False            False   \n",
+       "\n",
+       "    structure.bp_v  structure.grich_distance  structure.grich_angle  \\\n",
+       "0            False                   14.9753              51.023800   \n",
+       "1            False                   14.9753              51.023800   \n",
+       "..             ...                       ...                    ...   \n",
+       "12           False                   15.1080              51.288502   \n",
+       "13           False                   20.0054              66.349403   \n",
+       "\n",
+       "    structure.grich_rotation structure.filepath  structure.curation_flag  \n",
+       "0                  60.378601               <NA>                    False  \n",
+       "1                  60.378601               <NA>                    False  \n",
+       "..                       ...                ...                      ...  \n",
+       "12                 69.366898               <NA>                    False  \n",
+       "13                 48.160198               <NA>                    False  \n",
+       "\n",
+       "[14 rows x 46 columns]"
       ]
      },
      "execution_count": 61,
@@ -5571,6 +5760,7 @@
        "      <th>species.klifs</th>\n",
        "      <th>kinase.klifs_id</th>\n",
        "      <th>kinase.klifs_name</th>\n",
+       "      <th>kinase.names</th>\n",
        "      <th>kinase.family</th>\n",
        "      <th>kinase.group</th>\n",
        "      <th>structure.pocket</th>\n",
@@ -5588,6 +5778,7 @@
        "      <th>structure.missing_atoms</th>\n",
        "      <th>structure.rmsd1</th>\n",
        "      <th>structure.rmsd2</th>\n",
+       "      <th>interaction.fingerprint</th>\n",
        "      <th>structure.front</th>\n",
        "      <th>structure.gate</th>\n",
        "      <th>structure.back</th>\n",
@@ -5607,6 +5798,7 @@
        "      <th>structure.grich_angle</th>\n",
        "      <th>structure.grich_rotation</th>\n",
        "      <th>structure.filepath</th>\n",
+       "      <th>structure.curation_flag</th>\n",
        "    </tr>\n",
        "  </thead>\n",
        "  <tbody>\n",
@@ -5619,15 +5811,16 @@
        "      <td>Human</td>\n",
        "      <td>472</td>\n",
        "      <td>BMX</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>KELGSGQFGVVKLVAVKMIEFFQEAQTMMKLSPKLVKFYGVYIVTE...</td>\n",
        "      <td>PP2</td>\n",
        "      <td>-</td>\n",
        "      <td>632</td>\n",
        "      <td>0</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>out-like</td>\n",
        "      <td>in</td>\n",
        "      <td>1.89</td>\n",
@@ -5636,6 +5829,7 @@
        "      <td>0</td>\n",
        "      <td>0.834</td>\n",
        "      <td>2.106</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>True</td>\n",
        "      <td>True</td>\n",
        "      <td>False</td>\n",
@@ -5652,9 +5846,10 @@
        "      <td>False</td>\n",
        "      <td>False</td>\n",
        "      <td>15.3623</td>\n",
-       "      <td>50.7101</td>\n",
-       "      <td>62.7444</td>\n",
-       "      <td>None</td>\n",
+       "      <td>50.710098</td>\n",
+       "      <td>62.744400</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>False</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>1</th>\n",
@@ -5665,15 +5860,16 @@
        "      <td>Human</td>\n",
        "      <td>472</td>\n",
        "      <td>BMX</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>KEL______VVKLVAVKMIEFFQEAQTMMKLSPKLVKFYGVYIVTE...</td>\n",
        "      <td>1N1</td>\n",
        "      <td>-</td>\n",
        "      <td>281</td>\n",
        "      <td>0</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>out-like</td>\n",
        "      <td>in</td>\n",
        "      <td>2.40</td>\n",
@@ -5682,6 +5878,7 @@
        "      <td>0</td>\n",
        "      <td>0.839</td>\n",
        "      <td>1.946</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>True</td>\n",
        "      <td>True</td>\n",
        "      <td>False</td>\n",
@@ -5698,9 +5895,10 @@
        "      <td>False</td>\n",
        "      <td>False</td>\n",
        "      <td>0.0000</td>\n",
-       "      <td>0.0000</td>\n",
-       "      <td>0.0000</td>\n",
-       "      <td>None</td>\n",
+       "      <td>0.000000</td>\n",
+       "      <td>0.000000</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>False</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>...</th>\n",
@@ -5747,6 +5945,9 @@
        "      <td>...</td>\n",
        "      <td>...</td>\n",
        "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>225</th>\n",
@@ -5757,15 +5958,16 @@
        "      <td>Human</td>\n",
        "      <td>509</td>\n",
        "      <td>BRAF</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>QRIGSGSFGTVYKVAVKMLAFKNEVGVLRKTRVNILLFMGYAIVTQ...</td>\n",
        "      <td>2VX</td>\n",
        "      <td>-</td>\n",
        "      <td>945</td>\n",
        "      <td>0</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>in</td>\n",
        "      <td>out</td>\n",
        "      <td>3.40</td>\n",
@@ -5774,6 +5976,7 @@
        "      <td>0</td>\n",
        "      <td>0.813</td>\n",
        "      <td>2.142</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>True</td>\n",
        "      <td>True</td>\n",
        "      <td>True</td>\n",
@@ -5790,9 +5993,10 @@
        "      <td>False</td>\n",
        "      <td>False</td>\n",
        "      <td>17.1234</td>\n",
-       "      <td>55.5483</td>\n",
-       "      <td>31.8510</td>\n",
-       "      <td>None</td>\n",
+       "      <td>55.548302</td>\n",
+       "      <td>31.851000</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>False</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>226</th>\n",
@@ -5803,15 +6007,16 @@
        "      <td>Human</td>\n",
        "      <td>509</td>\n",
        "      <td>BRAF</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>QRIGSGSFGTVYKVAVKMLAFKNEVGVLRKTRVNILLFMGYAIVTQ...</td>\n",
        "      <td>SM5</td>\n",
        "      <td>-</td>\n",
        "      <td>249</td>\n",
        "      <td>0</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>in</td>\n",
        "      <td>in</td>\n",
        "      <td>2.80</td>\n",
@@ -5820,6 +6025,7 @@
        "      <td>0</td>\n",
        "      <td>0.779</td>\n",
        "      <td>2.120</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>True</td>\n",
        "      <td>True</td>\n",
        "      <td>False</td>\n",
@@ -5836,13 +6042,14 @@
        "      <td>False</td>\n",
        "      <td>False</td>\n",
        "      <td>14.7287</td>\n",
-       "      <td>49.4656</td>\n",
-       "      <td>72.6044</td>\n",
-       "      <td>None</td>\n",
+       "      <td>49.465599</td>\n",
+       "      <td>72.604401</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>False</td>\n",
        "    </tr>\n",
        "  </tbody>\n",
        "</table>\n",
-       "<p>227 rows × 43 columns</p>\n",
+       "<p>227 rows × 46 columns</p>\n",
        "</div>"
       ],
       "text/plain": [
@@ -5860,12 +6067,12 @@
        "225               B         Human              509              BRAF   \n",
        "226               A         Human              509              BRAF   \n",
        "\n",
-       "    kinase.family kinase.group  \\\n",
-       "0            None         None   \n",
-       "1            None         None   \n",
-       "..            ...          ...   \n",
-       "225          None         None   \n",
-       "226          None         None   \n",
+       "    kinase.names kinase.family kinase.group  \\\n",
+       "0           <NA>          <NA>         <NA>   \n",
+       "1           <NA>          <NA>         <NA>   \n",
+       "..           ...           ...          ...   \n",
+       "225         <NA>          <NA>         <NA>   \n",
+       "226         <NA>          <NA>         <NA>   \n",
        "\n",
        "                                      structure.pocket ligand.expo_id  \\\n",
        "0    KELGSGQFGVVKLVAVKMIEFFQEAQTMMKLSPKLVKFYGVYIVTE...            PP2   \n",
@@ -5882,11 +6089,11 @@
        "226                         -              249                           0   \n",
        "\n",
        "    ligand.name ligand_allosteric.name structure.dfg structure.ac_helix  \\\n",
-       "0          None                   None      out-like                 in   \n",
-       "1          None                   None      out-like                 in   \n",
+       "0          <NA>                   <NA>      out-like                 in   \n",
+       "1          <NA>                   <NA>      out-like                 in   \n",
        "..          ...                    ...           ...                ...   \n",
-       "225        None                   None            in                out   \n",
-       "226        None                   None            in                 in   \n",
+       "225        <NA>                   <NA>            in                out   \n",
+       "226        <NA>                   <NA>            in                 in   \n",
        "\n",
        "     structure.resolution  structure.qualityscore  structure.missing_residues  \\\n",
        "0                    1.89                     8.0                           0   \n",
@@ -5902,49 +6109,56 @@
        "225                        0            0.813            2.142   \n",
        "226                        0            0.779            2.120   \n",
        "\n",
-       "     structure.front  structure.gate  structure.back  structure.fp_i  \\\n",
-       "0               True            True           False           False   \n",
-       "1               True            True           False           False   \n",
-       "..               ...             ...             ...             ...   \n",
-       "225             True            True            True            True   \n",
-       "226             True            True           False           False   \n",
-       "\n",
-       "     structure.fp_ii  structure.bp_i_a  structure.bp_i_b  structure.bp_ii_in  \\\n",
-       "0              False             False              True               False   \n",
-       "1              False              True              True               False   \n",
-       "..               ...               ...               ...                 ...   \n",
-       "225            False              True              True                True   \n",
-       "226            False             False              True               False   \n",
-       "\n",
-       "     structure.bp_ii_a_in  structure.bp_ii_b_in  structure.bp_ii_out  \\\n",
-       "0                   False                 False                False   \n",
-       "1                   False                 False                False   \n",
-       "..                    ...                   ...                  ...   \n",
-       "225                 False                 False                False   \n",
-       "226                 False                 False                False   \n",
-       "\n",
-       "     structure.bp_ii_b  structure.bp_iii  structure.bp_iv  structure.bp_v  \\\n",
-       "0                False             False            False           False   \n",
-       "1                False             False            False           False   \n",
-       "..                 ...               ...              ...             ...   \n",
-       "225              False             False            False           False   \n",
-       "226              False             False            False           False   \n",
-       "\n",
-       "     structure.grich_distance  structure.grich_angle  \\\n",
-       "0                     15.3623                50.7101   \n",
-       "1                      0.0000                 0.0000   \n",
-       "..                        ...                    ...   \n",
-       "225                   17.1234                55.5483   \n",
-       "226                   14.7287                49.4656   \n",
-       "\n",
-       "     structure.grich_rotation structure.filepath  \n",
-       "0                     62.7444               None  \n",
-       "1                      0.0000               None  \n",
-       "..                        ...                ...  \n",
-       "225                   31.8510               None  \n",
-       "226                   72.6044               None  \n",
-       "\n",
-       "[227 rows x 43 columns]"
+       "    interaction.fingerprint  structure.front  structure.gate  structure.back  \\\n",
+       "0                      <NA>             True            True           False   \n",
+       "1                      <NA>             True            True           False   \n",
+       "..                      ...              ...             ...             ...   \n",
+       "225                    <NA>             True            True            True   \n",
+       "226                    <NA>             True            True           False   \n",
+       "\n",
+       "     structure.fp_i  structure.fp_ii  structure.bp_i_a  structure.bp_i_b  \\\n",
+       "0             False            False             False              True   \n",
+       "1             False            False              True              True   \n",
+       "..              ...              ...               ...               ...   \n",
+       "225            True            False              True              True   \n",
+       "226           False            False             False              True   \n",
+       "\n",
+       "     structure.bp_ii_in  structure.bp_ii_a_in  structure.bp_ii_b_in  \\\n",
+       "0                 False                 False                 False   \n",
+       "1                 False                 False                 False   \n",
+       "..                  ...                   ...                   ...   \n",
+       "225                True                 False                 False   \n",
+       "226               False                 False                 False   \n",
+       "\n",
+       "     structure.bp_ii_out  structure.bp_ii_b  structure.bp_iii  \\\n",
+       "0                  False              False             False   \n",
+       "1                  False              False             False   \n",
+       "..                   ...                ...               ...   \n",
+       "225                False              False             False   \n",
+       "226                False              False             False   \n",
+       "\n",
+       "     structure.bp_iv  structure.bp_v  structure.grich_distance  \\\n",
+       "0              False           False                   15.3623   \n",
+       "1              False           False                    0.0000   \n",
+       "..               ...             ...                       ...   \n",
+       "225            False           False                   17.1234   \n",
+       "226            False           False                   14.7287   \n",
+       "\n",
+       "     structure.grich_angle  structure.grich_rotation structure.filepath  \\\n",
+       "0                50.710098                 62.744400               <NA>   \n",
+       "1                 0.000000                  0.000000               <NA>   \n",
+       "..                     ...                       ...                ...   \n",
+       "225              55.548302                 31.851000               <NA>   \n",
+       "226              49.465599                 72.604401               <NA>   \n",
+       "\n",
+       "     structure.curation_flag  \n",
+       "0                      False  \n",
+       "1                      False  \n",
+       "..                       ...  \n",
+       "225                    False  \n",
+       "226                    False  \n",
+       "\n",
+       "[227 rows x 46 columns]"
       ]
      },
      "execution_count": 63,
@@ -6016,6 +6230,7 @@
        "      <th>species.klifs</th>\n",
        "      <th>kinase.klifs_id</th>\n",
        "      <th>kinase.klifs_name</th>\n",
+       "      <th>kinase.names</th>\n",
        "      <th>kinase.family</th>\n",
        "      <th>kinase.group</th>\n",
        "      <th>structure.pocket</th>\n",
@@ -6033,6 +6248,7 @@
        "      <th>structure.missing_atoms</th>\n",
        "      <th>structure.rmsd1</th>\n",
        "      <th>structure.rmsd2</th>\n",
+       "      <th>interaction.fingerprint</th>\n",
        "      <th>structure.front</th>\n",
        "      <th>structure.gate</th>\n",
        "      <th>structure.back</th>\n",
@@ -6052,6 +6268,7 @@
        "      <th>structure.grich_angle</th>\n",
        "      <th>structure.grich_rotation</th>\n",
        "      <th>structure.filepath</th>\n",
+       "      <th>structure.curation_flag</th>\n",
        "    </tr>\n",
        "  </thead>\n",
        "  <tbody>\n",
@@ -6064,13 +6281,14 @@
        "      <td>Human</td>\n",
        "      <td>472</td>\n",
        "      <td>BMX</td>\n",
+       "      <td>['BMX']</td>\n",
        "      <td>Tec</td>\n",
        "      <td>TK</td>\n",
        "      <td>KELGS____VVKLVAVKMIEFFQEAQTMMKLSPKLVKFYGVYIVTE...</td>\n",
        "      <td>1N1</td>\n",
        "      <td>-</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROX...</td>\n",
        "      <td>-</td>\n",
        "      <td>out-like</td>\n",
@@ -6081,25 +6299,27 @@
        "      <td>0</td>\n",
        "      <td>0.839</td>\n",
        "      <td>1.967</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>1</td>\n",
-       "      <td>1</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>0000000000000010000001000000000000000000000000...</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>True</td>\n",
+       "      <td>True</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>NaN</td>\n",
        "      <td>HUMAN/BMX/3sxr_chainA</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>1</th>\n",
@@ -6110,13 +6330,14 @@
        "      <td>Human</td>\n",
        "      <td>509</td>\n",
        "      <td>BRAF</td>\n",
+       "      <td>['BRAF']</td>\n",
        "      <td>RAF</td>\n",
        "      <td>TKL</td>\n",
        "      <td>QRI____FGTVYKVAVKMLAFKNEVGVLRKTRVNILLFMGYAIVTQ...</td>\n",
        "      <td>QH1</td>\n",
        "      <td>-</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>1-[4-{[1-(3-{[dihydroxy(propyl)-lambda~4~-sulf...</td>\n",
        "      <td>-</td>\n",
        "      <td>in</td>\n",
@@ -6127,25 +6348,27 @@
        "      <td>61</td>\n",
        "      <td>0.806</td>\n",
        "      <td>2.028</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>1</td>\n",
-       "      <td>1</td>\n",
-       "      <td>1</td>\n",
-       "      <td>1</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>0000000000000000000000000000000000000000000000...</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>True</td>\n",
+       "      <td>True</td>\n",
+       "      <td>True</td>\n",
+       "      <td>True</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>NaN</td>\n",
        "      <td>HUMAN/BRAF/6uuo_chainA</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "    </tr>\n",
        "  </tbody>\n",
        "</table>\n",
@@ -6160,17 +6383,17 @@
        "0               A         Human              472               BMX   \n",
        "1               A         Human              509              BRAF   \n",
        "\n",
-       "  kinase.family kinase.group  \\\n",
-       "0           Tec           TK   \n",
-       "1           RAF          TKL   \n",
+       "  kinase.names kinase.family kinase.group  \\\n",
+       "0      ['BMX']           Tec           TK   \n",
+       "1     ['BRAF']           RAF          TKL   \n",
        "\n",
        "                                    structure.pocket ligand.expo_id  \\\n",
        "0  KELGS____VVKLVAVKMIEFFQEAQTMMKLSPKLVKFYGVYIVTE...            1N1   \n",
        "1  QRI____FGTVYKVAVKMLAFKNEVGVLRKTRVNILLFMGYAIVTQ...            QH1   \n",
        "\n",
-       "  ligand_allosteric.expo_id ligand.klifs_id ligand_allosteric.klifs_id  \\\n",
-       "0                         -            None                       None   \n",
-       "1                         -            None                       None   \n",
+       "  ligand_allosteric.expo_id  ligand.klifs_id  ligand_allosteric.klifs_id  \\\n",
+       "0                         -             <NA>                        <NA>   \n",
+       "1                         -             <NA>                        <NA>   \n",
        "\n",
        "                                         ligand.name ligand_allosteric.name  \\\n",
        "0  N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROX...                      -   \n",
@@ -6184,33 +6407,37 @@
        "0                     6.4                           4   \n",
        "1                     5.2                           7   \n",
        "\n",
-       "   structure.missing_atoms  structure.rmsd1  structure.rmsd2 structure.front  \\\n",
-       "0                        0            0.839            1.967            None   \n",
-       "1                       61            0.806            2.028            None   \n",
+       "   structure.missing_atoms  structure.rmsd1  structure.rmsd2  \\\n",
+       "0                        0            0.839            1.967   \n",
+       "1                       61            0.806            2.028   \n",
        "\n",
-       "  structure.gate structure.back  structure.fp_i  structure.fp_ii  \\\n",
-       "0           None           None               0                0   \n",
-       "1           None           None               0                0   \n",
+       "                             interaction.fingerprint  structure.front  \\\n",
+       "0  0000000000000010000001000000000000000000000000...             <NA>   \n",
+       "1  0000000000000000000000000000000000000000000000...             <NA>   \n",
+       "\n",
+       "   structure.gate  structure.back  structure.fp_i  structure.fp_ii  \\\n",
+       "0            <NA>            <NA>           False            False   \n",
+       "1            <NA>            <NA>           False            False   \n",
        "\n",
        "   structure.bp_i_a  structure.bp_i_b  structure.bp_ii_in  \\\n",
-       "0                 1                 1                   0   \n",
-       "1                 1                 1                   1   \n",
+       "0              True              True               False   \n",
+       "1              True              True                True   \n",
        "\n",
        "   structure.bp_ii_a_in  structure.bp_ii_b_in  structure.bp_ii_out  \\\n",
-       "0                     0                     0                    0   \n",
-       "1                     1                     0                    0   \n",
+       "0                 False                 False                False   \n",
+       "1                  True                 False                False   \n",
        "\n",
        "   structure.bp_ii_b  structure.bp_iii  structure.bp_iv  structure.bp_v  \\\n",
-       "0                  0                 0                0               0   \n",
-       "1                  0                 0                0               0   \n",
+       "0              False             False            False           False   \n",
+       "1              False             False            False           False   \n",
        "\n",
-       "  structure.grich_distance structure.grich_angle structure.grich_rotation  \\\n",
-       "0                     None                  None                     None   \n",
-       "1                     None                  None                     None   \n",
+       "   structure.grich_distance  structure.grich_angle  structure.grich_rotation  \\\n",
+       "0                       NaN                    NaN                       NaN   \n",
+       "1                       NaN                    NaN                       NaN   \n",
        "\n",
-       "       structure.filepath  \n",
-       "0   HUMAN/BMX/3sxr_chainA  \n",
-       "1  HUMAN/BRAF/6uuo_chainA  "
+       "       structure.filepath  structure.curation_flag  \n",
+       "0   HUMAN/BMX/3sxr_chainA                     <NA>  \n",
+       "1  HUMAN/BRAF/6uuo_chainA                     <NA>  "
       ]
      },
      "execution_count": 65,
@@ -6289,6 +6516,7 @@
        "      <th>species.klifs</th>\n",
        "      <th>kinase.klifs_id</th>\n",
        "      <th>kinase.klifs_name</th>\n",
+       "      <th>kinase.names</th>\n",
        "      <th>kinase.family</th>\n",
        "      <th>kinase.group</th>\n",
        "      <th>structure.pocket</th>\n",
@@ -6306,6 +6534,7 @@
        "      <th>structure.missing_atoms</th>\n",
        "      <th>structure.rmsd1</th>\n",
        "      <th>structure.rmsd2</th>\n",
+       "      <th>interaction.fingerprint</th>\n",
        "      <th>structure.front</th>\n",
        "      <th>structure.gate</th>\n",
        "      <th>structure.back</th>\n",
@@ -6325,6 +6554,7 @@
        "      <th>structure.grich_angle</th>\n",
        "      <th>structure.grich_rotation</th>\n",
        "      <th>structure.filepath</th>\n",
+       "      <th>structure.curation_flag</th>\n",
        "    </tr>\n",
        "  </thead>\n",
        "  <tbody>\n",
@@ -6337,15 +6567,16 @@
        "      <td>Mouse</td>\n",
        "      <td>532</td>\n",
        "      <td>ABL1</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>HKLGGGQYGEVYEVAVKTLEFLKEAAVMKEIKPNLVQLLGVYIITE...</td>\n",
        "      <td>PRC</td>\n",
        "      <td>-</td>\n",
        "      <td>1793</td>\n",
        "      <td>0</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>out</td>\n",
        "      <td>in</td>\n",
        "      <td>2.4</td>\n",
@@ -6354,6 +6585,7 @@
        "      <td>4</td>\n",
        "      <td>0.925</td>\n",
        "      <td>2.329</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>True</td>\n",
        "      <td>True</td>\n",
        "      <td>True</td>\n",
@@ -6369,10 +6601,11 @@
        "      <td>False</td>\n",
        "      <td>False</td>\n",
        "      <td>False</td>\n",
-       "      <td>15.3329</td>\n",
-       "      <td>51.0939</td>\n",
-       "      <td>49.2289</td>\n",
-       "      <td>None</td>\n",
+       "      <td>15.332900</td>\n",
+       "      <td>51.093899</td>\n",
+       "      <td>49.228901</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>False</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>1</th>\n",
@@ -6383,15 +6616,16 @@
        "      <td>Mouse</td>\n",
        "      <td>532</td>\n",
        "      <td>ABL1</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>HKLGGGQYGEVYEVAVKTLEFLKEAAVMKEIKPNLVQLLGVYIITE...</td>\n",
        "      <td>PRC</td>\n",
        "      <td>-</td>\n",
        "      <td>1793</td>\n",
        "      <td>0</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>out</td>\n",
        "      <td>in</td>\n",
        "      <td>2.4</td>\n",
@@ -6400,6 +6634,7 @@
        "      <td>8</td>\n",
        "      <td>0.925</td>\n",
        "      <td>2.319</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>True</td>\n",
        "      <td>True</td>\n",
        "      <td>True</td>\n",
@@ -6415,10 +6650,11 @@
        "      <td>False</td>\n",
        "      <td>False</td>\n",
        "      <td>False</td>\n",
-       "      <td>16.1554</td>\n",
-       "      <td>54.1402</td>\n",
-       "      <td>48.7414</td>\n",
-       "      <td>None</td>\n",
+       "      <td>16.155399</td>\n",
+       "      <td>54.140202</td>\n",
+       "      <td>48.741402</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>False</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>2</th>\n",
@@ -6429,15 +6665,16 @@
        "      <td>Human</td>\n",
        "      <td>472</td>\n",
        "      <td>BMX</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>KEL______VVKLVAVKMIEFFQEAQTMMKLSPKLVKFYGVYIVTE...</td>\n",
        "      <td>1N1</td>\n",
        "      <td>-</td>\n",
        "      <td>281</td>\n",
        "      <td>0</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>out-like</td>\n",
        "      <td>in</td>\n",
        "      <td>2.4</td>\n",
@@ -6446,6 +6683,7 @@
        "      <td>0</td>\n",
        "      <td>0.839</td>\n",
        "      <td>1.946</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>True</td>\n",
        "      <td>True</td>\n",
        "      <td>False</td>\n",
@@ -6461,10 +6699,11 @@
        "      <td>False</td>\n",
        "      <td>False</td>\n",
        "      <td>False</td>\n",
-       "      <td>0.0000</td>\n",
-       "      <td>0.0000</td>\n",
-       "      <td>0.0000</td>\n",
-       "      <td>None</td>\n",
+       "      <td>0.000000</td>\n",
+       "      <td>0.000000</td>\n",
+       "      <td>0.000000</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>False</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>3</th>\n",
@@ -6475,15 +6714,16 @@
        "      <td>Human</td>\n",
        "      <td>472</td>\n",
        "      <td>BMX</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>KELGS____VVKLVAVKMIEFFQEAQTMMKLSPKLVKFYGVYIVTE...</td>\n",
        "      <td>1N1</td>\n",
        "      <td>-</td>\n",
        "      <td>281</td>\n",
        "      <td>0</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>out-like</td>\n",
        "      <td>in</td>\n",
        "      <td>2.4</td>\n",
@@ -6492,6 +6732,7 @@
        "      <td>0</td>\n",
        "      <td>0.839</td>\n",
        "      <td>1.967</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>True</td>\n",
        "      <td>True</td>\n",
        "      <td>False</td>\n",
@@ -6507,10 +6748,11 @@
        "      <td>False</td>\n",
        "      <td>False</td>\n",
        "      <td>False</td>\n",
-       "      <td>0.0000</td>\n",
-       "      <td>0.0000</td>\n",
-       "      <td>0.0000</td>\n",
-       "      <td>None</td>\n",
+       "      <td>0.000000</td>\n",
+       "      <td>0.000000</td>\n",
+       "      <td>0.000000</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>False</td>\n",
        "    </tr>\n",
        "  </tbody>\n",
        "</table>\n",
@@ -6529,11 +6771,11 @@
        "2               B         Human              472               BMX   \n",
        "3               A         Human              472               BMX   \n",
        "\n",
-       "  kinase.family kinase.group  \\\n",
-       "0          None         None   \n",
-       "1          None         None   \n",
-       "2          None         None   \n",
-       "3          None         None   \n",
+       "  kinase.names kinase.family kinase.group  \\\n",
+       "0         <NA>          <NA>         <NA>   \n",
+       "1         <NA>          <NA>         <NA>   \n",
+       "2         <NA>          <NA>         <NA>   \n",
+       "3         <NA>          <NA>         <NA>   \n",
        "\n",
        "                                    structure.pocket ligand.expo_id  \\\n",
        "0  HKLGGGQYGEVYEVAVKTLEFLKEAAVMKEIKPNLVQLLGVYIITE...            PRC   \n",
@@ -6548,10 +6790,10 @@
        "3                         -              281                           0   \n",
        "\n",
        "  ligand.name ligand_allosteric.name structure.dfg structure.ac_helix  \\\n",
-       "0        None                   None           out                 in   \n",
-       "1        None                   None           out                 in   \n",
-       "2        None                   None      out-like                 in   \n",
-       "3        None                   None      out-like                 in   \n",
+       "0        <NA>                   <NA>           out                 in   \n",
+       "1        <NA>                   <NA>           out                 in   \n",
+       "2        <NA>                   <NA>      out-like                 in   \n",
+       "3        <NA>                   <NA>      out-like                 in   \n",
        "\n",
        "   structure.resolution  structure.qualityscore  structure.missing_residues  \\\n",
        "0                   2.4                     9.2                           0   \n",
@@ -6559,47 +6801,47 @@
        "2                   2.4                     5.6                           6   \n",
        "3                   2.4                     6.4                           4   \n",
        "\n",
-       "   structure.missing_atoms  structure.rmsd1  structure.rmsd2  structure.front  \\\n",
-       "0                        4            0.925            2.329             True   \n",
-       "1                        8            0.925            2.319             True   \n",
-       "2                        0            0.839            1.946             True   \n",
-       "3                        0            0.839            1.967             True   \n",
-       "\n",
-       "   structure.gate  structure.back  structure.fp_i  structure.fp_ii  \\\n",
-       "0            True            True           False            False   \n",
-       "1            True            True           False            False   \n",
-       "2            True           False           False            False   \n",
-       "3            True           False           False            False   \n",
-       "\n",
-       "   structure.bp_i_a  structure.bp_i_b  structure.bp_ii_in  \\\n",
-       "0             False              True               False   \n",
-       "1              True              True               False   \n",
-       "2              True              True               False   \n",
-       "3              True              True               False   \n",
-       "\n",
-       "   structure.bp_ii_a_in  structure.bp_ii_b_in  structure.bp_ii_out  \\\n",
-       "0                 False                 False                 True   \n",
-       "1                 False                 False                 True   \n",
-       "2                 False                 False                False   \n",
-       "3                 False                 False                False   \n",
-       "\n",
-       "   structure.bp_ii_b  structure.bp_iii  structure.bp_iv  structure.bp_v  \\\n",
-       "0              False             False            False           False   \n",
-       "1              False             False            False           False   \n",
-       "2              False             False            False           False   \n",
-       "3              False             False            False           False   \n",
-       "\n",
-       "   structure.grich_distance  structure.grich_angle  structure.grich_rotation  \\\n",
-       "0                   15.3329                51.0939                   49.2289   \n",
-       "1                   16.1554                54.1402                   48.7414   \n",
-       "2                    0.0000                 0.0000                    0.0000   \n",
-       "3                    0.0000                 0.0000                    0.0000   \n",
-       "\n",
-       "  structure.filepath  \n",
-       "0               None  \n",
-       "1               None  \n",
-       "2               None  \n",
-       "3               None  "
+       "   structure.missing_atoms  structure.rmsd1  structure.rmsd2  \\\n",
+       "0                        4            0.925            2.329   \n",
+       "1                        8            0.925            2.319   \n",
+       "2                        0            0.839            1.946   \n",
+       "3                        0            0.839            1.967   \n",
+       "\n",
+       "  interaction.fingerprint  structure.front  structure.gate  structure.back  \\\n",
+       "0                    <NA>             True            True            True   \n",
+       "1                    <NA>             True            True            True   \n",
+       "2                    <NA>             True            True           False   \n",
+       "3                    <NA>             True            True           False   \n",
+       "\n",
+       "   structure.fp_i  structure.fp_ii  structure.bp_i_a  structure.bp_i_b  \\\n",
+       "0           False            False             False              True   \n",
+       "1           False            False              True              True   \n",
+       "2           False            False              True              True   \n",
+       "3           False            False              True              True   \n",
+       "\n",
+       "   structure.bp_ii_in  structure.bp_ii_a_in  structure.bp_ii_b_in  \\\n",
+       "0               False                 False                 False   \n",
+       "1               False                 False                 False   \n",
+       "2               False                 False                 False   \n",
+       "3               False                 False                 False   \n",
+       "\n",
+       "   structure.bp_ii_out  structure.bp_ii_b  structure.bp_iii  structure.bp_iv  \\\n",
+       "0                 True              False             False            False   \n",
+       "1                 True              False             False            False   \n",
+       "2                False              False             False            False   \n",
+       "3                False              False             False            False   \n",
+       "\n",
+       "   structure.bp_v  structure.grich_distance  structure.grich_angle  \\\n",
+       "0           False                 15.332900              51.093899   \n",
+       "1           False                 16.155399              54.140202   \n",
+       "2           False                  0.000000               0.000000   \n",
+       "3           False                  0.000000               0.000000   \n",
+       "\n",
+       "   structure.grich_rotation structure.filepath  structure.curation_flag  \n",
+       "0                 49.228901               <NA>                    False  \n",
+       "1                 48.741402               <NA>                    False  \n",
+       "2                  0.000000               <NA>                    False  \n",
+       "3                  0.000000               <NA>                    False  "
       ]
      },
      "execution_count": 67,
@@ -6671,6 +6913,7 @@
        "      <th>species.klifs</th>\n",
        "      <th>kinase.klifs_id</th>\n",
        "      <th>kinase.klifs_name</th>\n",
+       "      <th>kinase.names</th>\n",
        "      <th>kinase.family</th>\n",
        "      <th>kinase.group</th>\n",
        "      <th>structure.pocket</th>\n",
@@ -6688,6 +6931,7 @@
        "      <th>structure.missing_atoms</th>\n",
        "      <th>structure.rmsd1</th>\n",
        "      <th>structure.rmsd2</th>\n",
+       "      <th>interaction.fingerprint</th>\n",
        "      <th>structure.front</th>\n",
        "      <th>structure.gate</th>\n",
        "      <th>structure.back</th>\n",
@@ -6707,6 +6951,7 @@
        "      <th>structure.grich_angle</th>\n",
        "      <th>structure.grich_rotation</th>\n",
        "      <th>structure.filepath</th>\n",
+       "      <th>structure.curation_flag</th>\n",
        "    </tr>\n",
        "  </thead>\n",
        "  <tbody>\n",
@@ -6719,13 +6964,14 @@
        "      <td>Human</td>\n",
        "      <td>472</td>\n",
        "      <td>BMX</td>\n",
+       "      <td>['BMX']</td>\n",
        "      <td>Tec</td>\n",
        "      <td>TK</td>\n",
        "      <td>KELGS____VVKLVAVKMIEFFQEAQTMMKLSPKLVKFYGVYIVTE...</td>\n",
        "      <td>1N1</td>\n",
        "      <td>-</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROX...</td>\n",
        "      <td>-</td>\n",
        "      <td>out-like</td>\n",
@@ -6736,25 +6982,27 @@
        "      <td>0</td>\n",
        "      <td>0.839</td>\n",
        "      <td>1.967</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>1</td>\n",
-       "      <td>1</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>0000000000000010000001000000000000000000000000...</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>True</td>\n",
+       "      <td>True</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>NaN</td>\n",
        "      <td>HUMAN/BMX/3sxr_chainA</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>1</th>\n",
@@ -6765,13 +7013,14 @@
        "      <td>Mouse</td>\n",
        "      <td>532</td>\n",
        "      <td>ABL1</td>\n",
+       "      <td>['Abl1', 'ABL1']</td>\n",
        "      <td>Abl</td>\n",
        "      <td>TK</td>\n",
        "      <td>HKLGGGQYGEVYEVAVKTLEFLKEAAVMKEIKPNLVQLLGVYIITE...</td>\n",
        "      <td>PRC</td>\n",
        "      <td>-</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>N-[4-METHYL-3-[[4-(3-PYRIDINYL)-2-PYRIMIDINYL]...</td>\n",
        "      <td>-</td>\n",
        "      <td>out</td>\n",
@@ -6782,25 +7031,27 @@
        "      <td>8</td>\n",
        "      <td>0.925</td>\n",
        "      <td>2.319</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>1</td>\n",
-       "      <td>1</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>1</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>0000000000000010000000000000000000000000000000...</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>True</td>\n",
+       "      <td>True</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>True</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>NaN</td>\n",
        "      <td>MOUSE/ABL1/1fpu_chainA</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>2</th>\n",
@@ -6811,13 +7062,14 @@
        "      <td>Mouse</td>\n",
        "      <td>532</td>\n",
        "      <td>ABL1</td>\n",
+       "      <td>['Abl1', 'ABL1']</td>\n",
        "      <td>Abl</td>\n",
        "      <td>TK</td>\n",
        "      <td>HKLGGGQYGEVYEVAVKTLEFLKEAAVMKEIKPNLVQLLGVYIITE...</td>\n",
        "      <td>PRC</td>\n",
        "      <td>-</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>N-[4-METHYL-3-[[4-(3-PYRIDINYL)-2-PYRIMIDINYL]...</td>\n",
        "      <td>-</td>\n",
        "      <td>out</td>\n",
@@ -6828,25 +7080,27 @@
        "      <td>4</td>\n",
        "      <td>0.925</td>\n",
        "      <td>2.329</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>1</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>1</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>0000000000000010000000000000000000000000000000...</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>True</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>True</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>NaN</td>\n",
        "      <td>MOUSE/ABL1/1fpu_chainB</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "    </tr>\n",
        "  </tbody>\n",
        "</table>\n",
@@ -6863,20 +7117,20 @@
        "1               A         Mouse              532              ABL1   \n",
        "2               B         Mouse              532              ABL1   \n",
        "\n",
-       "  kinase.family kinase.group  \\\n",
-       "0           Tec           TK   \n",
-       "1           Abl           TK   \n",
-       "2           Abl           TK   \n",
+       "       kinase.names kinase.family kinase.group  \\\n",
+       "0           ['BMX']           Tec           TK   \n",
+       "1  ['Abl1', 'ABL1']           Abl           TK   \n",
+       "2  ['Abl1', 'ABL1']           Abl           TK   \n",
        "\n",
        "                                    structure.pocket ligand.expo_id  \\\n",
        "0  KELGS____VVKLVAVKMIEFFQEAQTMMKLSPKLVKFYGVYIVTE...            1N1   \n",
        "1  HKLGGGQYGEVYEVAVKTLEFLKEAAVMKEIKPNLVQLLGVYIITE...            PRC   \n",
        "2  HKLGGGQYGEVYEVAVKTLEFLKEAAVMKEIKPNLVQLLGVYIITE...            PRC   \n",
        "\n",
-       "  ligand_allosteric.expo_id ligand.klifs_id ligand_allosteric.klifs_id  \\\n",
-       "0                         -            None                       None   \n",
-       "1                         -            None                       None   \n",
-       "2                         -            None                       None   \n",
+       "  ligand_allosteric.expo_id  ligand.klifs_id  ligand_allosteric.klifs_id  \\\n",
+       "0                         -             <NA>                        <NA>   \n",
+       "1                         -             <NA>                        <NA>   \n",
+       "2                         -             <NA>                        <NA>   \n",
        "\n",
        "                                         ligand.name ligand_allosteric.name  \\\n",
        "0  N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROX...                      -   \n",
@@ -6893,40 +7147,45 @@
        "1                     8.8                           0   \n",
        "2                     9.2                           0   \n",
        "\n",
-       "   structure.missing_atoms  structure.rmsd1  structure.rmsd2 structure.front  \\\n",
-       "0                        0            0.839            1.967            None   \n",
-       "1                        8            0.925            2.319            None   \n",
-       "2                        4            0.925            2.329            None   \n",
+       "   structure.missing_atoms  structure.rmsd1  structure.rmsd2  \\\n",
+       "0                        0            0.839            1.967   \n",
+       "1                        8            0.925            2.319   \n",
+       "2                        4            0.925            2.329   \n",
+       "\n",
+       "                             interaction.fingerprint  structure.front  \\\n",
+       "0  0000000000000010000001000000000000000000000000...             <NA>   \n",
+       "1  0000000000000010000000000000000000000000000000...             <NA>   \n",
+       "2  0000000000000010000000000000000000000000000000...             <NA>   \n",
        "\n",
-       "  structure.gate structure.back  structure.fp_i  structure.fp_ii  \\\n",
-       "0           None           None               0                0   \n",
-       "1           None           None               0                0   \n",
-       "2           None           None               0                0   \n",
+       "   structure.gate  structure.back  structure.fp_i  structure.fp_ii  \\\n",
+       "0            <NA>            <NA>           False            False   \n",
+       "1            <NA>            <NA>           False            False   \n",
+       "2            <NA>            <NA>           False            False   \n",
        "\n",
        "   structure.bp_i_a  structure.bp_i_b  structure.bp_ii_in  \\\n",
-       "0                 1                 1                   0   \n",
-       "1                 1                 1                   0   \n",
-       "2                 0                 1                   0   \n",
+       "0              True              True               False   \n",
+       "1              True              True               False   \n",
+       "2             False              True               False   \n",
        "\n",
        "   structure.bp_ii_a_in  structure.bp_ii_b_in  structure.bp_ii_out  \\\n",
-       "0                     0                     0                    0   \n",
-       "1                     0                     0                    1   \n",
-       "2                     0                     0                    1   \n",
+       "0                 False                 False                False   \n",
+       "1                 False                 False                 True   \n",
+       "2                 False                 False                 True   \n",
        "\n",
        "   structure.bp_ii_b  structure.bp_iii  structure.bp_iv  structure.bp_v  \\\n",
-       "0                  0                 0                0               0   \n",
-       "1                  0                 0                0               0   \n",
-       "2                  0                 0                0               0   \n",
-       "\n",
-       "  structure.grich_distance structure.grich_angle structure.grich_rotation  \\\n",
-       "0                     None                  None                     None   \n",
-       "1                     None                  None                     None   \n",
-       "2                     None                  None                     None   \n",
-       "\n",
-       "       structure.filepath  \n",
-       "0   HUMAN/BMX/3sxr_chainA  \n",
-       "1  MOUSE/ABL1/1fpu_chainA  \n",
-       "2  MOUSE/ABL1/1fpu_chainB  "
+       "0              False             False            False           False   \n",
+       "1              False             False            False           False   \n",
+       "2              False             False            False           False   \n",
+       "\n",
+       "   structure.grich_distance  structure.grich_angle  structure.grich_rotation  \\\n",
+       "0                       NaN                    NaN                       NaN   \n",
+       "1                       NaN                    NaN                       NaN   \n",
+       "2                       NaN                    NaN                       NaN   \n",
+       "\n",
+       "       structure.filepath  structure.curation_flag  \n",
+       "0   HUMAN/BMX/3sxr_chainA                     <NA>  \n",
+       "1  MOUSE/ABL1/1fpu_chainA                     <NA>  \n",
+       "2  MOUSE/ABL1/1fpu_chainB                     <NA>  "
       ]
      },
      "execution_count": 69,
@@ -7005,6 +7264,7 @@
        "      <th>species.klifs</th>\n",
        "      <th>kinase.klifs_id</th>\n",
        "      <th>kinase.klifs_name</th>\n",
+       "      <th>kinase.names</th>\n",
        "      <th>kinase.family</th>\n",
        "      <th>kinase.group</th>\n",
        "      <th>structure.pocket</th>\n",
@@ -7022,6 +7282,7 @@
        "      <th>structure.missing_atoms</th>\n",
        "      <th>structure.rmsd1</th>\n",
        "      <th>structure.rmsd2</th>\n",
+       "      <th>interaction.fingerprint</th>\n",
        "      <th>structure.front</th>\n",
        "      <th>structure.gate</th>\n",
        "      <th>structure.back</th>\n",
@@ -7041,6 +7302,7 @@
        "      <th>structure.grich_angle</th>\n",
        "      <th>structure.grich_rotation</th>\n",
        "      <th>structure.filepath</th>\n",
+       "      <th>structure.curation_flag</th>\n",
        "    </tr>\n",
        "  </thead>\n",
        "  <tbody>\n",
@@ -7053,15 +7315,16 @@
        "      <td>Human</td>\n",
        "      <td>249</td>\n",
        "      <td>p38a</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>SPVGS__YGSVCAVAVKKLRTYRELRLLKHMKENVIGLLDVYLVTH...</td>\n",
        "      <td>1N1</td>\n",
        "      <td>-</td>\n",
        "      <td>281</td>\n",
        "      <td>0</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>na</td>\n",
        "      <td>in</td>\n",
        "      <td>2.10</td>\n",
@@ -7070,6 +7333,7 @@
        "      <td>15</td>\n",
        "      <td>0.765</td>\n",
        "      <td>2.173</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>True</td>\n",
        "      <td>True</td>\n",
        "      <td>True</td>\n",
@@ -7085,10 +7349,11 @@
        "      <td>False</td>\n",
        "      <td>False</td>\n",
        "      <td>False</td>\n",
-       "      <td>0.0000</td>\n",
-       "      <td>0.0000</td>\n",
-       "      <td>0.0000</td>\n",
-       "      <td>None</td>\n",
+       "      <td>0.000000</td>\n",
+       "      <td>0.000000</td>\n",
+       "      <td>0.000000</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>False</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>1</th>\n",
@@ -7099,15 +7364,16 @@
        "      <td>Human</td>\n",
        "      <td>334</td>\n",
        "      <td>MYT1</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>SRLGHGSYGEVFKYAVKRSRKLAEVGSHEKVGPCCVRLEQAYLQTE...</td>\n",
        "      <td>1N1</td>\n",
        "      <td>-</td>\n",
        "      <td>281</td>\n",
        "      <td>0</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>in</td>\n",
        "      <td>in</td>\n",
        "      <td>1.92</td>\n",
@@ -7116,6 +7382,7 @@
        "      <td>0</td>\n",
        "      <td>0.775</td>\n",
        "      <td>2.104</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>True</td>\n",
        "      <td>True</td>\n",
        "      <td>False</td>\n",
@@ -7131,10 +7398,11 @@
        "      <td>False</td>\n",
        "      <td>False</td>\n",
        "      <td>False</td>\n",
-       "      <td>18.5518</td>\n",
-       "      <td>59.8744</td>\n",
-       "      <td>54.6185</td>\n",
-       "      <td>None</td>\n",
+       "      <td>18.551800</td>\n",
+       "      <td>59.874401</td>\n",
+       "      <td>54.618500</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>False</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>...</th>\n",
@@ -7181,6 +7449,9 @@
        "      <td>...</td>\n",
        "      <td>...</td>\n",
        "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>37</th>\n",
@@ -7191,15 +7462,16 @@
        "      <td>Mouse</td>\n",
        "      <td>668</td>\n",
        "      <td>EphA4</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>KVIGVGEFGEVCSVAIKTLDFLSEASIMGQFDPNIIHLEGVMIITE...</td>\n",
        "      <td>1N1</td>\n",
        "      <td>-</td>\n",
        "      <td>281</td>\n",
        "      <td>0</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>in</td>\n",
        "      <td>in</td>\n",
        "      <td>1.54</td>\n",
@@ -7208,6 +7480,7 @@
        "      <td>1</td>\n",
        "      <td>0.783</td>\n",
        "      <td>2.116</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>True</td>\n",
        "      <td>True</td>\n",
        "      <td>True</td>\n",
@@ -7223,10 +7496,11 @@
        "      <td>False</td>\n",
        "      <td>False</td>\n",
        "      <td>False</td>\n",
-       "      <td>19.3129</td>\n",
-       "      <td>61.7605</td>\n",
-       "      <td>52.2424</td>\n",
-       "      <td>None</td>\n",
+       "      <td>19.312901</td>\n",
+       "      <td>61.760502</td>\n",
+       "      <td>52.242401</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>False</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>38</th>\n",
@@ -7237,15 +7511,16 @@
        "      <td>Mouse</td>\n",
        "      <td>767</td>\n",
        "      <td>LYN</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>KKLGAGQFGEVWMVAVKTLAFLEEANLMKTLQDKLVRLYAVYIITE...</td>\n",
        "      <td>1N1</td>\n",
        "      <td>-</td>\n",
        "      <td>281</td>\n",
        "      <td>0</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>in</td>\n",
        "      <td>in</td>\n",
        "      <td>2.60</td>\n",
@@ -7254,6 +7529,7 @@
        "      <td>0</td>\n",
        "      <td>0.780</td>\n",
        "      <td>2.099</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>True</td>\n",
        "      <td>True</td>\n",
        "      <td>True</td>\n",
@@ -7269,14 +7545,15 @@
        "      <td>False</td>\n",
        "      <td>False</td>\n",
        "      <td>False</td>\n",
-       "      <td>19.2971</td>\n",
-       "      <td>62.3627</td>\n",
-       "      <td>53.8728</td>\n",
-       "      <td>None</td>\n",
+       "      <td>19.297100</td>\n",
+       "      <td>62.362701</td>\n",
+       "      <td>53.872799</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>False</td>\n",
        "    </tr>\n",
        "  </tbody>\n",
        "</table>\n",
-       "<p>39 rows × 43 columns</p>\n",
+       "<p>39 rows × 46 columns</p>\n",
        "</div>"
       ],
       "text/plain": [
@@ -7294,12 +7571,12 @@
        "37               A         Mouse              668             EphA4   \n",
        "38               A         Mouse              767               LYN   \n",
        "\n",
-       "   kinase.family kinase.group  \\\n",
-       "0           None         None   \n",
-       "1           None         None   \n",
-       "..           ...          ...   \n",
-       "37          None         None   \n",
-       "38          None         None   \n",
+       "   kinase.names kinase.family kinase.group  \\\n",
+       "0          <NA>          <NA>         <NA>   \n",
+       "1          <NA>          <NA>         <NA>   \n",
+       "..          ...           ...          ...   \n",
+       "37         <NA>          <NA>         <NA>   \n",
+       "38         <NA>          <NA>         <NA>   \n",
        "\n",
        "                                     structure.pocket ligand.expo_id  \\\n",
        "0   SPVGS__YGSVCAVAVKKLRTYRELRLLKHMKENVIGLLDVYLVTH...            1N1   \n",
@@ -7316,11 +7593,11 @@
        "38                         -              281                           0   \n",
        "\n",
        "   ligand.name ligand_allosteric.name structure.dfg structure.ac_helix  \\\n",
-       "0         None                   None            na                 in   \n",
-       "1         None                   None            in                 in   \n",
+       "0         <NA>                   <NA>            na                 in   \n",
+       "1         <NA>                   <NA>            in                 in   \n",
        "..         ...                    ...           ...                ...   \n",
-       "37        None                   None            in                 in   \n",
-       "38        None                   None            in                 in   \n",
+       "37        <NA>                   <NA>            in                 in   \n",
+       "38        <NA>                   <NA>            in                 in   \n",
        "\n",
        "    structure.resolution  structure.qualityscore  structure.missing_residues  \\\n",
        "0                   2.10                     6.1                           5   \n",
@@ -7336,49 +7613,49 @@
        "37                        1            0.783            2.116   \n",
        "38                        0            0.780            2.099   \n",
        "\n",
-       "    structure.front  structure.gate  structure.back  structure.fp_i  \\\n",
-       "0              True            True            True           False   \n",
-       "1              True            True           False           False   \n",
-       "..              ...             ...             ...             ...   \n",
-       "37             True            True            True           False   \n",
-       "38             True            True            True           False   \n",
-       "\n",
-       "    structure.fp_ii  structure.bp_i_a  structure.bp_i_b  structure.bp_ii_in  \\\n",
-       "0             False              True              True               False   \n",
-       "1             False              True              True               False   \n",
-       "..              ...               ...               ...                 ...   \n",
-       "37            False              True              True               False   \n",
-       "38            False              True              True               False   \n",
-       "\n",
-       "    structure.bp_ii_a_in  structure.bp_ii_b_in  structure.bp_ii_out  \\\n",
-       "0                  False                 False                False   \n",
-       "1                  False                 False                False   \n",
-       "..                   ...                   ...                  ...   \n",
-       "37                 False                 False                False   \n",
-       "38                 False                 False                False   \n",
-       "\n",
-       "    structure.bp_ii_b  structure.bp_iii  structure.bp_iv  structure.bp_v  \\\n",
-       "0               False             False            False           False   \n",
-       "1               False             False            False           False   \n",
-       "..                ...               ...              ...             ...   \n",
-       "37              False             False            False           False   \n",
-       "38              False             False            False           False   \n",
-       "\n",
-       "    structure.grich_distance  structure.grich_angle  structure.grich_rotation  \\\n",
-       "0                     0.0000                 0.0000                    0.0000   \n",
-       "1                    18.5518                59.8744                   54.6185   \n",
-       "..                       ...                    ...                       ...   \n",
-       "37                   19.3129                61.7605                   52.2424   \n",
-       "38                   19.2971                62.3627                   53.8728   \n",
-       "\n",
-       "   structure.filepath  \n",
-       "0                None  \n",
-       "1                None  \n",
-       "..                ...  \n",
-       "37               None  \n",
-       "38               None  \n",
-       "\n",
-       "[39 rows x 43 columns]"
+       "   interaction.fingerprint  structure.front  structure.gate  structure.back  \\\n",
+       "0                     <NA>             True            True            True   \n",
+       "1                     <NA>             True            True           False   \n",
+       "..                     ...              ...             ...             ...   \n",
+       "37                    <NA>             True            True            True   \n",
+       "38                    <NA>             True            True            True   \n",
+       "\n",
+       "    structure.fp_i  structure.fp_ii  structure.bp_i_a  structure.bp_i_b  \\\n",
+       "0            False            False              True              True   \n",
+       "1            False            False              True              True   \n",
+       "..             ...              ...               ...               ...   \n",
+       "37           False            False              True              True   \n",
+       "38           False            False              True              True   \n",
+       "\n",
+       "    structure.bp_ii_in  structure.bp_ii_a_in  structure.bp_ii_b_in  \\\n",
+       "0                False                 False                 False   \n",
+       "1                False                 False                 False   \n",
+       "..                 ...                   ...                   ...   \n",
+       "37               False                 False                 False   \n",
+       "38               False                 False                 False   \n",
+       "\n",
+       "    structure.bp_ii_out  structure.bp_ii_b  structure.bp_iii  structure.bp_iv  \\\n",
+       "0                 False              False             False            False   \n",
+       "1                 False              False             False            False   \n",
+       "..                  ...                ...               ...              ...   \n",
+       "37                False              False             False            False   \n",
+       "38                False              False             False            False   \n",
+       "\n",
+       "    structure.bp_v  structure.grich_distance  structure.grich_angle  \\\n",
+       "0            False                  0.000000               0.000000   \n",
+       "1            False                 18.551800              59.874401   \n",
+       "..             ...                       ...                    ...   \n",
+       "37           False                 19.312901              61.760502   \n",
+       "38           False                 19.297100              62.362701   \n",
+       "\n",
+       "    structure.grich_rotation structure.filepath  structure.curation_flag  \n",
+       "0                   0.000000               <NA>                    False  \n",
+       "1                  54.618500               <NA>                    False  \n",
+       "..                       ...                ...                      ...  \n",
+       "37                 52.242401               <NA>                    False  \n",
+       "38                 53.872799               <NA>                    False  \n",
+       "\n",
+       "[39 rows x 46 columns]"
       ]
      },
      "execution_count": 71,
@@ -7450,6 +7727,7 @@
        "      <th>species.klifs</th>\n",
        "      <th>kinase.klifs_id</th>\n",
        "      <th>kinase.klifs_name</th>\n",
+       "      <th>kinase.names</th>\n",
        "      <th>kinase.family</th>\n",
        "      <th>kinase.group</th>\n",
        "      <th>structure.pocket</th>\n",
@@ -7467,6 +7745,7 @@
        "      <th>structure.missing_atoms</th>\n",
        "      <th>structure.rmsd1</th>\n",
        "      <th>structure.rmsd2</th>\n",
+       "      <th>interaction.fingerprint</th>\n",
        "      <th>structure.front</th>\n",
        "      <th>structure.gate</th>\n",
        "      <th>structure.back</th>\n",
@@ -7486,6 +7765,7 @@
        "      <th>structure.grich_angle</th>\n",
        "      <th>structure.grich_rotation</th>\n",
        "      <th>structure.filepath</th>\n",
+       "      <th>structure.curation_flag</th>\n",
        "    </tr>\n",
        "  </thead>\n",
        "  <tbody>\n",
@@ -7498,13 +7778,14 @@
        "      <td>Human</td>\n",
        "      <td>472</td>\n",
        "      <td>BMX</td>\n",
+       "      <td>['BMX']</td>\n",
        "      <td>Tec</td>\n",
        "      <td>TK</td>\n",
        "      <td>KELGS____VVKLVAVKMIEFFQEAQTMMKLSPKLVKFYGVYIVTE...</td>\n",
        "      <td>1N1</td>\n",
        "      <td>-</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROX...</td>\n",
        "      <td>-</td>\n",
        "      <td>out-like</td>\n",
@@ -7515,25 +7796,27 @@
        "      <td>0</td>\n",
        "      <td>0.839</td>\n",
        "      <td>1.967</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>1</td>\n",
-       "      <td>1</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>0000000000000010000001000000000000000000000000...</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>True</td>\n",
+       "      <td>True</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>NaN</td>\n",
        "      <td>HUMAN/BMX/3sxr_chainA</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>1</th>\n",
@@ -7544,13 +7827,14 @@
        "      <td>Mouse</td>\n",
        "      <td>532</td>\n",
        "      <td>ABL1</td>\n",
+       "      <td>['Abl1', 'ABL1']</td>\n",
        "      <td>Abl</td>\n",
        "      <td>TK</td>\n",
        "      <td>HKLGGGQYGEVYEVAVKTLEFLKEAAVMKEIKPNLVQLLGVYIITE...</td>\n",
        "      <td>PRC</td>\n",
        "      <td>-</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>N-[4-METHYL-3-[[4-(3-PYRIDINYL)-2-PYRIMIDINYL]...</td>\n",
        "      <td>-</td>\n",
        "      <td>out</td>\n",
@@ -7561,25 +7845,27 @@
        "      <td>8</td>\n",
        "      <td>0.925</td>\n",
        "      <td>2.319</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>1</td>\n",
-       "      <td>1</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>1</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>0000000000000010000000000000000000000000000000...</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>True</td>\n",
+       "      <td>True</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>True</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>NaN</td>\n",
        "      <td>MOUSE/ABL1/1fpu_chainA</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>2</th>\n",
@@ -7590,13 +7876,14 @@
        "      <td>Mouse</td>\n",
        "      <td>532</td>\n",
        "      <td>ABL1</td>\n",
+       "      <td>['Abl1', 'ABL1']</td>\n",
        "      <td>Abl</td>\n",
        "      <td>TK</td>\n",
        "      <td>HKLGGGQYGEVYEVAVKTLEFLKEAAVMKEIKPNLVQLLGVYIITE...</td>\n",
        "      <td>PRC</td>\n",
        "      <td>-</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>N-[4-METHYL-3-[[4-(3-PYRIDINYL)-2-PYRIMIDINYL]...</td>\n",
        "      <td>-</td>\n",
        "      <td>out</td>\n",
@@ -7607,25 +7894,27 @@
        "      <td>4</td>\n",
        "      <td>0.925</td>\n",
        "      <td>2.329</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>1</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>1</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>0000000000000010000000000000000000000000000000...</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>True</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>True</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>NaN</td>\n",
        "      <td>MOUSE/ABL1/1fpu_chainB</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "    </tr>\n",
        "  </tbody>\n",
        "</table>\n",
@@ -7642,20 +7931,20 @@
        "1               A         Mouse              532              ABL1   \n",
        "2               B         Mouse              532              ABL1   \n",
        "\n",
-       "  kinase.family kinase.group  \\\n",
-       "0           Tec           TK   \n",
-       "1           Abl           TK   \n",
-       "2           Abl           TK   \n",
+       "       kinase.names kinase.family kinase.group  \\\n",
+       "0           ['BMX']           Tec           TK   \n",
+       "1  ['Abl1', 'ABL1']           Abl           TK   \n",
+       "2  ['Abl1', 'ABL1']           Abl           TK   \n",
        "\n",
        "                                    structure.pocket ligand.expo_id  \\\n",
        "0  KELGS____VVKLVAVKMIEFFQEAQTMMKLSPKLVKFYGVYIVTE...            1N1   \n",
        "1  HKLGGGQYGEVYEVAVKTLEFLKEAAVMKEIKPNLVQLLGVYIITE...            PRC   \n",
        "2  HKLGGGQYGEVYEVAVKTLEFLKEAAVMKEIKPNLVQLLGVYIITE...            PRC   \n",
        "\n",
-       "  ligand_allosteric.expo_id ligand.klifs_id ligand_allosteric.klifs_id  \\\n",
-       "0                         -            None                       None   \n",
-       "1                         -            None                       None   \n",
-       "2                         -            None                       None   \n",
+       "  ligand_allosteric.expo_id  ligand.klifs_id  ligand_allosteric.klifs_id  \\\n",
+       "0                         -             <NA>                        <NA>   \n",
+       "1                         -             <NA>                        <NA>   \n",
+       "2                         -             <NA>                        <NA>   \n",
        "\n",
        "                                         ligand.name ligand_allosteric.name  \\\n",
        "0  N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROX...                      -   \n",
@@ -7672,40 +7961,45 @@
        "1                     8.8                           0   \n",
        "2                     9.2                           0   \n",
        "\n",
-       "   structure.missing_atoms  structure.rmsd1  structure.rmsd2 structure.front  \\\n",
-       "0                        0            0.839            1.967            None   \n",
-       "1                        8            0.925            2.319            None   \n",
-       "2                        4            0.925            2.329            None   \n",
+       "   structure.missing_atoms  structure.rmsd1  structure.rmsd2  \\\n",
+       "0                        0            0.839            1.967   \n",
+       "1                        8            0.925            2.319   \n",
+       "2                        4            0.925            2.329   \n",
+       "\n",
+       "                             interaction.fingerprint  structure.front  \\\n",
+       "0  0000000000000010000001000000000000000000000000...             <NA>   \n",
+       "1  0000000000000010000000000000000000000000000000...             <NA>   \n",
+       "2  0000000000000010000000000000000000000000000000...             <NA>   \n",
        "\n",
-       "  structure.gate structure.back  structure.fp_i  structure.fp_ii  \\\n",
-       "0           None           None               0                0   \n",
-       "1           None           None               0                0   \n",
-       "2           None           None               0                0   \n",
+       "   structure.gate  structure.back  structure.fp_i  structure.fp_ii  \\\n",
+       "0            <NA>            <NA>           False            False   \n",
+       "1            <NA>            <NA>           False            False   \n",
+       "2            <NA>            <NA>           False            False   \n",
        "\n",
        "   structure.bp_i_a  structure.bp_i_b  structure.bp_ii_in  \\\n",
-       "0                 1                 1                   0   \n",
-       "1                 1                 1                   0   \n",
-       "2                 0                 1                   0   \n",
+       "0              True              True               False   \n",
+       "1              True              True               False   \n",
+       "2             False              True               False   \n",
        "\n",
        "   structure.bp_ii_a_in  structure.bp_ii_b_in  structure.bp_ii_out  \\\n",
-       "0                     0                     0                    0   \n",
-       "1                     0                     0                    1   \n",
-       "2                     0                     0                    1   \n",
+       "0                 False                 False                False   \n",
+       "1                 False                 False                 True   \n",
+       "2                 False                 False                 True   \n",
        "\n",
        "   structure.bp_ii_b  structure.bp_iii  structure.bp_iv  structure.bp_v  \\\n",
-       "0                  0                 0                0               0   \n",
-       "1                  0                 0                0               0   \n",
-       "2                  0                 0                0               0   \n",
-       "\n",
-       "  structure.grich_distance structure.grich_angle structure.grich_rotation  \\\n",
-       "0                     None                  None                     None   \n",
-       "1                     None                  None                     None   \n",
-       "2                     None                  None                     None   \n",
-       "\n",
-       "       structure.filepath  \n",
-       "0   HUMAN/BMX/3sxr_chainA  \n",
-       "1  MOUSE/ABL1/1fpu_chainA  \n",
-       "2  MOUSE/ABL1/1fpu_chainB  "
+       "0              False             False            False           False   \n",
+       "1              False             False            False           False   \n",
+       "2              False             False            False           False   \n",
+       "\n",
+       "   structure.grich_distance  structure.grich_angle  structure.grich_rotation  \\\n",
+       "0                       NaN                    NaN                       NaN   \n",
+       "1                       NaN                    NaN                       NaN   \n",
+       "2                       NaN                    NaN                       NaN   \n",
+       "\n",
+       "       structure.filepath  structure.curation_flag  \n",
+       "0   HUMAN/BMX/3sxr_chainA                     <NA>  \n",
+       "1  MOUSE/ABL1/1fpu_chainA                     <NA>  \n",
+       "2  MOUSE/ABL1/1fpu_chainB                     <NA>  "
       ]
      },
      "execution_count": 73,
@@ -7784,6 +8078,7 @@
        "      <th>species.klifs</th>\n",
        "      <th>kinase.klifs_id</th>\n",
        "      <th>kinase.klifs_name</th>\n",
+       "      <th>kinase.names</th>\n",
        "      <th>kinase.family</th>\n",
        "      <th>kinase.group</th>\n",
        "      <th>structure.pocket</th>\n",
@@ -7801,6 +8096,7 @@
        "      <th>structure.missing_atoms</th>\n",
        "      <th>structure.rmsd1</th>\n",
        "      <th>structure.rmsd2</th>\n",
+       "      <th>interaction.fingerprint</th>\n",
        "      <th>structure.front</th>\n",
        "      <th>structure.gate</th>\n",
        "      <th>structure.back</th>\n",
@@ -7820,6 +8116,7 @@
        "      <th>structure.grich_angle</th>\n",
        "      <th>structure.grich_rotation</th>\n",
        "      <th>structure.filepath</th>\n",
+       "      <th>structure.curation_flag</th>\n",
        "    </tr>\n",
        "  </thead>\n",
        "  <tbody>\n",
@@ -7832,15 +8129,16 @@
        "      <td>Human</td>\n",
        "      <td>392</td>\n",
        "      <td>ABL1</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>HKLGEGQYGEVYEVAVKTLEFLKEAAVLKEIKPNLVQLLGVYIITE...</td>\n",
        "      <td>-</td>\n",
        "      <td>-</td>\n",
        "      <td>0</td>\n",
        "      <td>0</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>out</td>\n",
        "      <td>in</td>\n",
        "      <td>NaN</td>\n",
@@ -7849,6 +8147,7 @@
        "      <td>0</td>\n",
        "      <td>0.949</td>\n",
        "      <td>2.476</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>False</td>\n",
        "      <td>False</td>\n",
        "      <td>False</td>\n",
@@ -7864,10 +8163,11 @@
        "      <td>False</td>\n",
        "      <td>False</td>\n",
        "      <td>False</td>\n",
-       "      <td>17.8558</td>\n",
-       "      <td>64.9730</td>\n",
-       "      <td>72.90380</td>\n",
-       "      <td>None</td>\n",
+       "      <td>17.855801</td>\n",
+       "      <td>64.973000</td>\n",
+       "      <td>72.903801</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>False</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>1</th>\n",
@@ -7878,15 +8178,16 @@
        "      <td>Human</td>\n",
        "      <td>392</td>\n",
        "      <td>ABL1</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>HKLGGGQYGEVYEVAVKTLEFLKEAAVMKEIKPNLVQLLGVYIITE...</td>\n",
        "      <td>NIL</td>\n",
        "      <td>-</td>\n",
        "      <td>277</td>\n",
        "      <td>0</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>out</td>\n",
        "      <td>in</td>\n",
        "      <td>2.21</td>\n",
@@ -7895,6 +8196,7 @@
        "      <td>0</td>\n",
        "      <td>0.937</td>\n",
        "      <td>2.245</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>True</td>\n",
        "      <td>True</td>\n",
        "      <td>True</td>\n",
@@ -7910,10 +8212,11 @@
        "      <td>True</td>\n",
        "      <td>False</td>\n",
        "      <td>True</td>\n",
-       "      <td>18.3528</td>\n",
-       "      <td>61.4986</td>\n",
-       "      <td>11.32480</td>\n",
-       "      <td>None</td>\n",
+       "      <td>18.352800</td>\n",
+       "      <td>61.498600</td>\n",
+       "      <td>11.324800</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>False</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>...</th>\n",
@@ -7960,6 +8263,9 @@
        "      <td>...</td>\n",
        "      <td>...</td>\n",
        "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>205</th>\n",
@@ -7970,15 +8276,16 @@
        "      <td>Mouse</td>\n",
        "      <td>532</td>\n",
        "      <td>ABL1</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>HKLGGGQYGEVYEVAVKTLEFLKEAAVMKEIKPNLVQLLGVYIITE...</td>\n",
        "      <td>B90</td>\n",
        "      <td>-</td>\n",
        "      <td>1799</td>\n",
        "      <td>0</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>in</td>\n",
        "      <td>in</td>\n",
        "      <td>1.90</td>\n",
@@ -7987,6 +8294,7 @@
        "      <td>0</td>\n",
        "      <td>0.781</td>\n",
        "      <td>2.148</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>True</td>\n",
        "      <td>True</td>\n",
        "      <td>True</td>\n",
@@ -8002,10 +8310,11 @@
        "      <td>False</td>\n",
        "      <td>False</td>\n",
        "      <td>False</td>\n",
-       "      <td>18.1219</td>\n",
-       "      <td>59.6546</td>\n",
-       "      <td>8.66056</td>\n",
-       "      <td>None</td>\n",
+       "      <td>18.121901</td>\n",
+       "      <td>59.654598</td>\n",
+       "      <td>8.660560</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>False</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>206</th>\n",
@@ -8016,15 +8325,16 @@
        "      <td>Mouse</td>\n",
        "      <td>532</td>\n",
        "      <td>ABL1</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>HKLGGGQYGEVYEVAVKTLEFLKEAAVMKEIKPNLVQLLGVYIITE...</td>\n",
        "      <td>STI</td>\n",
        "      <td>STJ</td>\n",
        "      <td>48</td>\n",
        "      <td>1796</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>out</td>\n",
        "      <td>in</td>\n",
        "      <td>1.74</td>\n",
@@ -8033,6 +8343,7 @@
        "      <td>0</td>\n",
        "      <td>0.924</td>\n",
        "      <td>2.310</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>True</td>\n",
        "      <td>True</td>\n",
        "      <td>True</td>\n",
@@ -8048,14 +8359,15 @@
        "      <td>False</td>\n",
        "      <td>True</td>\n",
        "      <td>False</td>\n",
-       "      <td>18.7011</td>\n",
-       "      <td>62.8702</td>\n",
-       "      <td>12.68090</td>\n",
-       "      <td>None</td>\n",
+       "      <td>18.701099</td>\n",
+       "      <td>62.870201</td>\n",
+       "      <td>12.680900</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>False</td>\n",
        "    </tr>\n",
        "  </tbody>\n",
        "</table>\n",
-       "<p>207 rows × 43 columns</p>\n",
+       "<p>207 rows × 46 columns</p>\n",
        "</div>"
       ],
       "text/plain": [
@@ -8073,12 +8385,12 @@
        "205               A         Mouse              532              ABL1   \n",
        "206               A         Mouse              532              ABL1   \n",
        "\n",
-       "    kinase.family kinase.group  \\\n",
-       "0            None         None   \n",
-       "1            None         None   \n",
-       "..            ...          ...   \n",
-       "205          None         None   \n",
-       "206          None         None   \n",
+       "    kinase.names kinase.family kinase.group  \\\n",
+       "0           <NA>          <NA>         <NA>   \n",
+       "1           <NA>          <NA>         <NA>   \n",
+       "..           ...           ...          ...   \n",
+       "205         <NA>          <NA>         <NA>   \n",
+       "206         <NA>          <NA>         <NA>   \n",
        "\n",
        "                                      structure.pocket ligand.expo_id  \\\n",
        "0    HKLGEGQYGEVYEVAVKTLEFLKEAAVLKEIKPNLVQLLGVYIITE...              -   \n",
@@ -8095,11 +8407,11 @@
        "206                       STJ               48                        1796   \n",
        "\n",
        "    ligand.name ligand_allosteric.name structure.dfg structure.ac_helix  \\\n",
-       "0          None                   None           out                 in   \n",
-       "1          None                   None           out                 in   \n",
+       "0          <NA>                   <NA>           out                 in   \n",
+       "1          <NA>                   <NA>           out                 in   \n",
        "..          ...                    ...           ...                ...   \n",
-       "205        None                   None            in                 in   \n",
-       "206        None                   None           out                 in   \n",
+       "205        <NA>                   <NA>            in                 in   \n",
+       "206        <NA>                   <NA>           out                 in   \n",
        "\n",
        "     structure.resolution  structure.qualityscore  structure.missing_residues  \\\n",
        "0                     NaN                     7.6                           0   \n",
@@ -8115,49 +8427,56 @@
        "205                        0            0.781            2.148   \n",
        "206                        0            0.924            2.310   \n",
        "\n",
-       "     structure.front  structure.gate  structure.back  structure.fp_i  \\\n",
-       "0              False           False           False           False   \n",
-       "1               True            True            True           False   \n",
-       "..               ...             ...             ...             ...   \n",
-       "205             True            True            True           False   \n",
-       "206             True            True            True           False   \n",
-       "\n",
-       "     structure.fp_ii  structure.bp_i_a  structure.bp_i_b  structure.bp_ii_in  \\\n",
-       "0              False             False             False               False   \n",
-       "1              False              True              True               False   \n",
-       "..               ...               ...               ...                 ...   \n",
-       "205            False              True              True               False   \n",
-       "206            False              True              True               False   \n",
-       "\n",
-       "     structure.bp_ii_a_in  structure.bp_ii_b_in  structure.bp_ii_out  \\\n",
-       "0                   False                 False                False   \n",
-       "1                   False                 False                 True   \n",
-       "..                    ...                   ...                  ...   \n",
-       "205                 False                 False                False   \n",
-       "206                 False                 False                 True   \n",
-       "\n",
-       "     structure.bp_ii_b  structure.bp_iii  structure.bp_iv  structure.bp_v  \\\n",
-       "0                False             False            False           False   \n",
-       "1                False              True            False            True   \n",
-       "..                 ...               ...              ...             ...   \n",
-       "205              False             False            False           False   \n",
-       "206              False             False             True           False   \n",
-       "\n",
-       "     structure.grich_distance  structure.grich_angle  \\\n",
-       "0                     17.8558                64.9730   \n",
-       "1                     18.3528                61.4986   \n",
-       "..                        ...                    ...   \n",
-       "205                   18.1219                59.6546   \n",
-       "206                   18.7011                62.8702   \n",
-       "\n",
-       "     structure.grich_rotation structure.filepath  \n",
-       "0                    72.90380               None  \n",
-       "1                    11.32480               None  \n",
-       "..                        ...                ...  \n",
-       "205                   8.66056               None  \n",
-       "206                  12.68090               None  \n",
-       "\n",
-       "[207 rows x 43 columns]"
+       "    interaction.fingerprint  structure.front  structure.gate  structure.back  \\\n",
+       "0                      <NA>            False           False           False   \n",
+       "1                      <NA>             True            True            True   \n",
+       "..                      ...              ...             ...             ...   \n",
+       "205                    <NA>             True            True            True   \n",
+       "206                    <NA>             True            True            True   \n",
+       "\n",
+       "     structure.fp_i  structure.fp_ii  structure.bp_i_a  structure.bp_i_b  \\\n",
+       "0             False            False             False             False   \n",
+       "1             False            False              True              True   \n",
+       "..              ...              ...               ...               ...   \n",
+       "205           False            False              True              True   \n",
+       "206           False            False              True              True   \n",
+       "\n",
+       "     structure.bp_ii_in  structure.bp_ii_a_in  structure.bp_ii_b_in  \\\n",
+       "0                 False                 False                 False   \n",
+       "1                 False                 False                 False   \n",
+       "..                  ...                   ...                   ...   \n",
+       "205               False                 False                 False   \n",
+       "206               False                 False                 False   \n",
+       "\n",
+       "     structure.bp_ii_out  structure.bp_ii_b  structure.bp_iii  \\\n",
+       "0                  False              False             False   \n",
+       "1                   True              False              True   \n",
+       "..                   ...                ...               ...   \n",
+       "205                False              False             False   \n",
+       "206                 True              False             False   \n",
+       "\n",
+       "     structure.bp_iv  structure.bp_v  structure.grich_distance  \\\n",
+       "0              False           False                 17.855801   \n",
+       "1              False            True                 18.352800   \n",
+       "..               ...             ...                       ...   \n",
+       "205            False           False                 18.121901   \n",
+       "206             True           False                 18.701099   \n",
+       "\n",
+       "     structure.grich_angle  structure.grich_rotation structure.filepath  \\\n",
+       "0                64.973000                 72.903801               <NA>   \n",
+       "1                61.498600                 11.324800               <NA>   \n",
+       "..                     ...                       ...                ...   \n",
+       "205              59.654598                  8.660560               <NA>   \n",
+       "206              62.870201                 12.680900               <NA>   \n",
+       "\n",
+       "     structure.curation_flag  \n",
+       "0                      False  \n",
+       "1                      False  \n",
+       "..                       ...  \n",
+       "205                    False  \n",
+       "206                    False  \n",
+       "\n",
+       "[207 rows x 46 columns]"
       ]
      },
      "execution_count": 75,
@@ -8229,6 +8548,7 @@
        "      <th>species.klifs</th>\n",
        "      <th>kinase.klifs_id</th>\n",
        "      <th>kinase.klifs_name</th>\n",
+       "      <th>kinase.names</th>\n",
        "      <th>kinase.family</th>\n",
        "      <th>kinase.group</th>\n",
        "      <th>structure.pocket</th>\n",
@@ -8246,6 +8566,7 @@
        "      <th>structure.missing_atoms</th>\n",
        "      <th>structure.rmsd1</th>\n",
        "      <th>structure.rmsd2</th>\n",
+       "      <th>interaction.fingerprint</th>\n",
        "      <th>structure.front</th>\n",
        "      <th>structure.gate</th>\n",
        "      <th>structure.back</th>\n",
@@ -8265,6 +8586,7 @@
        "      <th>structure.grich_angle</th>\n",
        "      <th>structure.grich_rotation</th>\n",
        "      <th>structure.filepath</th>\n",
+       "      <th>structure.curation_flag</th>\n",
        "    </tr>\n",
        "  </thead>\n",
        "  <tbody>\n",
@@ -8277,13 +8599,14 @@
        "      <td>Human</td>\n",
        "      <td>472</td>\n",
        "      <td>BMX</td>\n",
+       "      <td>['BMX']</td>\n",
        "      <td>Tec</td>\n",
        "      <td>TK</td>\n",
        "      <td>KELGS____VVKLVAVKMIEFFQEAQTMMKLSPKLVKFYGVYIVTE...</td>\n",
        "      <td>1N1</td>\n",
        "      <td>-</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROX...</td>\n",
        "      <td>-</td>\n",
        "      <td>out-like</td>\n",
@@ -8294,25 +8617,27 @@
        "      <td>0</td>\n",
        "      <td>0.839</td>\n",
        "      <td>1.967</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>1</td>\n",
-       "      <td>1</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>0000000000000010000001000000000000000000000000...</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>True</td>\n",
+       "      <td>True</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>NaN</td>\n",
        "      <td>HUMAN/BMX/3sxr_chainA</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>1</th>\n",
@@ -8323,13 +8648,14 @@
        "      <td>Mouse</td>\n",
        "      <td>532</td>\n",
        "      <td>ABL1</td>\n",
+       "      <td>['Abl1', 'ABL1']</td>\n",
        "      <td>Abl</td>\n",
        "      <td>TK</td>\n",
        "      <td>HKLGGGQYGEVYEVAVKTLEFLKEAAVMKEIKPNLVQLLGVYIITE...</td>\n",
        "      <td>PRC</td>\n",
        "      <td>-</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>N-[4-METHYL-3-[[4-(3-PYRIDINYL)-2-PYRIMIDINYL]...</td>\n",
        "      <td>-</td>\n",
        "      <td>out</td>\n",
@@ -8340,25 +8666,27 @@
        "      <td>8</td>\n",
        "      <td>0.925</td>\n",
        "      <td>2.319</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>1</td>\n",
-       "      <td>1</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>1</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>0000000000000010000000000000000000000000000000...</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>True</td>\n",
+       "      <td>True</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>True</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>NaN</td>\n",
        "      <td>MOUSE/ABL1/1fpu_chainA</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>2</th>\n",
@@ -8369,13 +8697,14 @@
        "      <td>Mouse</td>\n",
        "      <td>532</td>\n",
        "      <td>ABL1</td>\n",
+       "      <td>['Abl1', 'ABL1']</td>\n",
        "      <td>Abl</td>\n",
        "      <td>TK</td>\n",
        "      <td>HKLGGGQYGEVYEVAVKTLEFLKEAAVMKEIKPNLVQLLGVYIITE...</td>\n",
        "      <td>PRC</td>\n",
        "      <td>-</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>N-[4-METHYL-3-[[4-(3-PYRIDINYL)-2-PYRIMIDINYL]...</td>\n",
        "      <td>-</td>\n",
        "      <td>out</td>\n",
@@ -8386,25 +8715,27 @@
        "      <td>4</td>\n",
        "      <td>0.925</td>\n",
        "      <td>2.329</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>1</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>1</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>0</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
-       "      <td>None</td>\n",
+       "      <td>0000000000000010000000000000000000000000000000...</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>True</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>True</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>False</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>NaN</td>\n",
+       "      <td>NaN</td>\n",
        "      <td>MOUSE/ABL1/1fpu_chainB</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "    </tr>\n",
        "  </tbody>\n",
        "</table>\n",
@@ -8421,20 +8752,20 @@
        "1               A         Mouse              532              ABL1   \n",
        "2               B         Mouse              532              ABL1   \n",
        "\n",
-       "  kinase.family kinase.group  \\\n",
-       "0           Tec           TK   \n",
-       "1           Abl           TK   \n",
-       "2           Abl           TK   \n",
+       "       kinase.names kinase.family kinase.group  \\\n",
+       "0           ['BMX']           Tec           TK   \n",
+       "1  ['Abl1', 'ABL1']           Abl           TK   \n",
+       "2  ['Abl1', 'ABL1']           Abl           TK   \n",
        "\n",
        "                                    structure.pocket ligand.expo_id  \\\n",
        "0  KELGS____VVKLVAVKMIEFFQEAQTMMKLSPKLVKFYGVYIVTE...            1N1   \n",
        "1  HKLGGGQYGEVYEVAVKTLEFLKEAAVMKEIKPNLVQLLGVYIITE...            PRC   \n",
        "2  HKLGGGQYGEVYEVAVKTLEFLKEAAVMKEIKPNLVQLLGVYIITE...            PRC   \n",
        "\n",
-       "  ligand_allosteric.expo_id ligand.klifs_id ligand_allosteric.klifs_id  \\\n",
-       "0                         -            None                       None   \n",
-       "1                         -            None                       None   \n",
-       "2                         -            None                       None   \n",
+       "  ligand_allosteric.expo_id  ligand.klifs_id  ligand_allosteric.klifs_id  \\\n",
+       "0                         -             <NA>                        <NA>   \n",
+       "1                         -             <NA>                        <NA>   \n",
+       "2                         -             <NA>                        <NA>   \n",
        "\n",
        "                                         ligand.name ligand_allosteric.name  \\\n",
        "0  N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROX...                      -   \n",
@@ -8451,40 +8782,45 @@
        "1                     8.8                           0   \n",
        "2                     9.2                           0   \n",
        "\n",
-       "   structure.missing_atoms  structure.rmsd1  structure.rmsd2 structure.front  \\\n",
-       "0                        0            0.839            1.967            None   \n",
-       "1                        8            0.925            2.319            None   \n",
-       "2                        4            0.925            2.329            None   \n",
+       "   structure.missing_atoms  structure.rmsd1  structure.rmsd2  \\\n",
+       "0                        0            0.839            1.967   \n",
+       "1                        8            0.925            2.319   \n",
+       "2                        4            0.925            2.329   \n",
        "\n",
-       "  structure.gate structure.back  structure.fp_i  structure.fp_ii  \\\n",
-       "0           None           None               0                0   \n",
-       "1           None           None               0                0   \n",
-       "2           None           None               0                0   \n",
+       "                             interaction.fingerprint  structure.front  \\\n",
+       "0  0000000000000010000001000000000000000000000000...             <NA>   \n",
+       "1  0000000000000010000000000000000000000000000000...             <NA>   \n",
+       "2  0000000000000010000000000000000000000000000000...             <NA>   \n",
+       "\n",
+       "   structure.gate  structure.back  structure.fp_i  structure.fp_ii  \\\n",
+       "0            <NA>            <NA>           False            False   \n",
+       "1            <NA>            <NA>           False            False   \n",
+       "2            <NA>            <NA>           False            False   \n",
        "\n",
        "   structure.bp_i_a  structure.bp_i_b  structure.bp_ii_in  \\\n",
-       "0                 1                 1                   0   \n",
-       "1                 1                 1                   0   \n",
-       "2                 0                 1                   0   \n",
+       "0              True              True               False   \n",
+       "1              True              True               False   \n",
+       "2             False              True               False   \n",
        "\n",
        "   structure.bp_ii_a_in  structure.bp_ii_b_in  structure.bp_ii_out  \\\n",
-       "0                     0                     0                    0   \n",
-       "1                     0                     0                    1   \n",
-       "2                     0                     0                    1   \n",
+       "0                 False                 False                False   \n",
+       "1                 False                 False                 True   \n",
+       "2                 False                 False                 True   \n",
        "\n",
        "   structure.bp_ii_b  structure.bp_iii  structure.bp_iv  structure.bp_v  \\\n",
-       "0                  0                 0                0               0   \n",
-       "1                  0                 0                0               0   \n",
-       "2                  0                 0                0               0   \n",
-       "\n",
-       "  structure.grich_distance structure.grich_angle structure.grich_rotation  \\\n",
-       "0                     None                  None                     None   \n",
-       "1                     None                  None                     None   \n",
-       "2                     None                  None                     None   \n",
-       "\n",
-       "       structure.filepath  \n",
-       "0   HUMAN/BMX/3sxr_chainA  \n",
-       "1  MOUSE/ABL1/1fpu_chainA  \n",
-       "2  MOUSE/ABL1/1fpu_chainB  "
+       "0              False             False            False           False   \n",
+       "1              False             False            False           False   \n",
+       "2              False             False            False           False   \n",
+       "\n",
+       "   structure.grich_distance  structure.grich_angle  structure.grich_rotation  \\\n",
+       "0                       NaN                    NaN                       NaN   \n",
+       "1                       NaN                    NaN                       NaN   \n",
+       "2                       NaN                    NaN                       NaN   \n",
+       "\n",
+       "       structure.filepath  structure.curation_flag  \n",
+       "0   HUMAN/BMX/3sxr_chainA                     <NA>  \n",
+       "1  MOUSE/ABL1/1fpu_chainA                     <NA>  \n",
+       "2  MOUSE/ABL1/1fpu_chainB                     <NA>  "
       ]
      },
      "execution_count": 77,
@@ -8547,7 +8883,7 @@
     {
      "data": {
       "application/vnd.jupyter.widget-view+json": {
-       "model_id": "3f046af45dc447d9b02f485dfd164c38",
+       "model_id": "0681f9b0e434422491c2f694353a6f9e",
        "version_major": 2,
        "version_minor": 0
       },
@@ -8600,7 +8936,7 @@
        "      <td>CHEMBL552425</td>\n",
        "      <td>IC50</td>\n",
        "      <td>=</td>\n",
-       "      <td>18.6</td>\n",
+       "      <td>18.60</td>\n",
        "      <td>nM</td>\n",
        "      <td>7.73</td>\n",
        "      <td>Homo sapiens</td>\n",
@@ -8613,7 +8949,7 @@
        "      <td>CHEMBL552425</td>\n",
        "      <td>EC50</td>\n",
        "      <td>=</td>\n",
-       "      <td>40.0</td>\n",
+       "      <td>40.00</td>\n",
        "      <td>nM</td>\n",
        "      <td>7.40</td>\n",
        "      <td>Homo sapiens</td>\n",
@@ -8639,7 +8975,7 @@
        "      <td>CHEMBL3086536</td>\n",
        "      <td>Ki</td>\n",
        "      <td>=</td>\n",
-       "      <td>55.0</td>\n",
+       "      <td>55.00</td>\n",
        "      <td>nM</td>\n",
        "      <td>7.26</td>\n",
        "      <td>Homo sapiens</td>\n",
@@ -8677,19 +9013,19 @@
        "540    CHEMBL3086536                               Ki   \n",
        "541    CHEMBL3263052                               Ki   \n",
        "\n",
-       "    ligand.bioactivity_standard_relation ligand.bioactivity_standard_value  \\\n",
-       "0                                      =                              18.6   \n",
-       "1                                      =                              40.0   \n",
-       "..                                   ...                               ...   \n",
-       "540                                    =                              55.0   \n",
-       "541                                    =                              0.93   \n",
+       "    ligand.bioactivity_standard_relation  ligand.bioactivity_standard_value  \\\n",
+       "0                                      =                              18.60   \n",
+       "1                                      =                              40.00   \n",
+       "..                                   ...                                ...   \n",
+       "540                                    =                              55.00   \n",
+       "541                                    =                               0.93   \n",
        "\n",
-       "    ligand.bioactivity_standard_units ligand.bioactivity_pchembl_value  \\\n",
-       "0                                  nM                             7.73   \n",
-       "1                                  nM                             7.40   \n",
-       "..                                ...                              ...   \n",
-       "540                                nM                             7.26   \n",
-       "541                                nM                             9.03   \n",
+       "    ligand.bioactivity_standard_units  ligand.bioactivity_pchembl_value  \\\n",
+       "0                                  nM                              7.73   \n",
+       "1                                  nM                              7.40   \n",
+       "..                                ...                               ...   \n",
+       "540                                nM                              7.26   \n",
+       "541                                nM                              9.03   \n",
        "\n",
        "    species.chembl  \n",
        "0     Homo sapiens  \n",
@@ -8743,7 +9079,7 @@
     {
      "data": {
       "application/vnd.jupyter.widget-view+json": {
-       "model_id": "dd0de47d97a7444b94d1bcad22c0fff4",
+       "model_id": "f70759a55dca4a8a9cc0b35eb21c8023",
        "version_major": 2,
        "version_minor": 0
       },
@@ -8758,15 +9094,15 @@
      "name": "stderr",
      "output_type": "stream",
      "text": [
-      "ERROR:opencadd.databases.klifs.core:There was (were) 1/2 failed request(s).\n",
+      "There was (were) 1/2 failed request(s).\n",
       "Show error messages (up to 5 messages only):\n",
-      "ERROR:opencadd.databases.klifs.core:Error for 10000: Expected type to be dict for value [400, 'KLIFS error: The provided kinase ID(s) is/are invalid'] to unmarshal to a <class 'abc.Error'>.Was <class 'list'> instead.\n"
+      "Error for 10000: Expected type to be dict for value [400, 'KLIFS error: The provided kinase ID(s) is/are invalid'] to unmarshal to a <class 'abc.Error'>.Was <class 'list'> instead.\n"
      ]
     },
     {
      "data": {
       "application/vnd.jupyter.widget-view+json": {
-       "model_id": "2b36a89ea4b84b3b93aeb7ae5efcba71",
+       "model_id": "6d31d6f4f31d46beaa02317f38e7df00",
        "version_major": 2,
        "version_minor": 0
       },
@@ -8781,9 +9117,9 @@
      "name": "stderr",
      "output_type": "stream",
      "text": [
-      "ERROR:opencadd.databases.klifs.core:There was (were) 2/3 failed request(s).\n",
+      "There was (were) 2/3 failed request(s).\n",
       "Show error messages (up to 5 messages only):\n",
-      "ERROR:opencadd.databases.klifs.core:Error for 632: Expected type to be dict for value [400, 'KLIFS error: This ligand is not available in ChEMBL.'] to unmarshal to a <class 'abc.Error'>.Was <class 'list'> instead.\n",
+      "Error for 632: Expected type to be dict for value [400, 'KLIFS error: This ligand is not available in ChEMBL.'] to unmarshal to a <class 'abc.Error'>.Was <class 'list'> instead.\n",
       "Error for 3716: Expected type to be dict for value [400, 'KLIFS error: This ligand is not available in ChEMBL.'] to unmarshal to a <class 'abc.Error'>.Was <class 'list'> instead.\n"
      ]
     },
@@ -8829,7 +9165,7 @@
        "      <td>CHEMBL1421</td>\n",
        "      <td>Kd</td>\n",
        "      <td>=</td>\n",
-       "      <td>620.0</td>\n",
+       "      <td>620.00</td>\n",
        "      <td>nM</td>\n",
        "      <td>6.21</td>\n",
        "      <td>Homo sapiens</td>\n",
@@ -8868,7 +9204,7 @@
        "      <td>CHEMBL1421</td>\n",
        "      <td>Kd</td>\n",
        "      <td>=</td>\n",
-       "      <td>200.0</td>\n",
+       "      <td>200.00</td>\n",
        "      <td>nM</td>\n",
        "      <td>6.70</td>\n",
        "      <td>Homo sapiens</td>\n",
@@ -8881,7 +9217,7 @@
        "      <td>CHEMBL1421</td>\n",
        "      <td>Kd</td>\n",
        "      <td>=</td>\n",
-       "      <td>481.0</td>\n",
+       "      <td>481.00</td>\n",
        "      <td>nM</td>\n",
        "      <td>6.32</td>\n",
        "      <td>Homo sapiens</td>\n",
@@ -8906,19 +9242,19 @@
        "289       CHEMBL1421                               Kd   \n",
        "290       CHEMBL1421                               Kd   \n",
        "\n",
-       "    ligand.bioactivity_standard_relation ligand.bioactivity_standard_value  \\\n",
-       "0                                      =                             620.0   \n",
-       "1                                      =                             79.43   \n",
-       "..                                   ...                               ...   \n",
-       "289                                    =                             200.0   \n",
-       "290                                    =                             481.0   \n",
+       "    ligand.bioactivity_standard_relation  ligand.bioactivity_standard_value  \\\n",
+       "0                                      =                             620.00   \n",
+       "1                                      =                              79.43   \n",
+       "..                                   ...                                ...   \n",
+       "289                                    =                             200.00   \n",
+       "290                                    =                             481.00   \n",
        "\n",
-       "    ligand.bioactivity_standard_units ligand.bioactivity_pchembl_value  \\\n",
-       "0                                  nM                             6.21   \n",
-       "1                                  nM                             7.10   \n",
-       "..                                ...                              ...   \n",
-       "289                                nM                             6.70   \n",
-       "290                                nM                             6.32   \n",
+       "    ligand.bioactivity_standard_units  ligand.bioactivity_pchembl_value  \\\n",
+       "0                                  nM                              6.21   \n",
+       "1                                  nM                              7.10   \n",
+       "..                                ...                               ...   \n",
+       "289                                nM                              6.70   \n",
+       "290                                nM                              6.32   \n",
        "\n",
        "    species.chembl  \n",
        "0     Homo sapiens  \n",
@@ -8947,7 +9283,7 @@
     {
      "data": {
       "application/vnd.jupyter.widget-view+json": {
-       "model_id": "7a031fa0718e4ac18e5d7fdd885c6c82",
+       "model_id": "ca494d28fb914a1891543af72992db28",
        "version_major": 2,
        "version_minor": 0
       },
@@ -8962,9 +9298,9 @@
      "name": "stderr",
      "output_type": "stream",
      "text": [
-      "ERROR:opencadd.databases.klifs.core:There was (were) 1/1 failed request(s).\n",
+      "There was (were) 1/1 failed request(s).\n",
       "Show error messages (up to 5 messages only):\n",
-      "ERROR:opencadd.databases.klifs.core:Error for 10000000: Expected type to be dict for value [400, 'KLIFS error: The provided kinase ID(s) is/are invalid'] to unmarshal to a <class 'abc.Error'>.Was <class 'list'> instead.\n"
+      "Error for 10000000: Expected type to be dict for value [400, 'KLIFS error: The provided kinase ID(s) is/are invalid'] to unmarshal to a <class 'abc.Error'>.Was <class 'list'> instead.\n"
      ]
     },
     {
@@ -9006,7 +9342,7 @@
     {
      "data": {
       "application/vnd.jupyter.widget-view+json": {
-       "model_id": "3275998906c441d8afe60a8a7ba8d9c6",
+       "model_id": "d278b183a0b04c4cb878a7bff64fd793",
        "version_major": 2,
        "version_minor": 0
       },
@@ -9021,9 +9357,9 @@
      "name": "stderr",
      "output_type": "stream",
      "text": [
-      "ERROR:opencadd.databases.klifs.core:There was (were) 1/3 failed request(s).\n",
+      "There was (were) 1/3 failed request(s).\n",
       "Show error messages (up to 5 messages only):\n",
-      "ERROR:opencadd.databases.klifs.core:Error for 10000: Expected type to be dict for value [400, 'KLIFS error: Could not find a ligand with the provided ID.'] to unmarshal to a <class 'abc.Error'>.Was <class 'list'> instead.\n"
+      "Error for 10000: Expected type to be dict for value [400, 'KLIFS error: Could not find a ligand with the provided ID.'] to unmarshal to a <class 'abc.Error'>.Was <class 'list'> instead.\n"
      ]
     },
     {
@@ -9057,6 +9393,7 @@
        "      <th>ligand.bioactivity_standard_units</th>\n",
        "      <th>ligand.bioactivity_pchembl_value</th>\n",
        "      <th>species.chembl</th>\n",
+       "      <th>ligand.klifs_id (query)</th>\n",
        "    </tr>\n",
        "  </thead>\n",
        "  <tbody>\n",
@@ -9072,6 +9409,7 @@
        "      <td>nM</td>\n",
        "      <td>10.80</td>\n",
        "      <td>Oryctolagus cuniculus</td>\n",
+       "      <td>100</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>1</th>\n",
@@ -9081,10 +9419,11 @@
        "      <td>CHEMBL281948</td>\n",
        "      <td>IC50</td>\n",
        "      <td>=</td>\n",
-       "      <td>0.02</td>\n",
+       "      <td>0.020</td>\n",
        "      <td>nM</td>\n",
        "      <td>10.70</td>\n",
        "      <td>Gallus gallus</td>\n",
+       "      <td>100</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>...</th>\n",
@@ -9098,6 +9437,7 @@
        "      <td>...</td>\n",
        "      <td>...</td>\n",
        "      <td>...</td>\n",
+       "      <td>...</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>7</th>\n",
@@ -9107,10 +9447,11 @@
        "      <td>CHEMBL281948</td>\n",
        "      <td>IC50</td>\n",
        "      <td>=</td>\n",
-       "      <td>43.0</td>\n",
+       "      <td>43.000</td>\n",
        "      <td>nM</td>\n",
        "      <td>7.37</td>\n",
        "      <td>Homo sapiens</td>\n",
+       "      <td>100</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>8</th>\n",
@@ -9120,14 +9461,15 @@
        "      <td>CHEMBL523435</td>\n",
        "      <td>IC50</td>\n",
        "      <td>=</td>\n",
-       "      <td>247.0</td>\n",
+       "      <td>247.000</td>\n",
        "      <td>nM</td>\n",
        "      <td>6.61</td>\n",
        "      <td>Homo sapiens</td>\n",
+       "      <td>200</td>\n",
        "    </tr>\n",
        "  </tbody>\n",
        "</table>\n",
-       "<p>9 rows × 10 columns</p>\n",
+       "<p>9 rows × 11 columns</p>\n",
        "</div>"
       ],
       "text/plain": [
@@ -9145,28 +9487,28 @@
        "7         CHEMBL279     CHEMBL281948                             IC50   \n",
        "8         CHEMBL262     CHEMBL523435                             IC50   \n",
        "\n",
-       "   ligand.bioactivity_standard_relation ligand.bioactivity_standard_value  \\\n",
-       "0                                     =                             0.016   \n",
-       "1                                     =                              0.02   \n",
-       "..                                  ...                               ...   \n",
-       "7                                     =                              43.0   \n",
-       "8                                     =                             247.0   \n",
-       "\n",
-       "   ligand.bioactivity_standard_units ligand.bioactivity_pchembl_value  \\\n",
-       "0                                 nM                            10.80   \n",
-       "1                                 nM                            10.70   \n",
-       "..                               ...                              ...   \n",
-       "7                                 nM                             7.37   \n",
-       "8                                 nM                             6.61   \n",
-       "\n",
-       "           species.chembl  \n",
-       "0   Oryctolagus cuniculus  \n",
-       "1           Gallus gallus  \n",
-       "..                    ...  \n",
-       "7            Homo sapiens  \n",
-       "8            Homo sapiens  \n",
-       "\n",
-       "[9 rows x 10 columns]"
+       "   ligand.bioactivity_standard_relation  ligand.bioactivity_standard_value  \\\n",
+       "0                                     =                              0.016   \n",
+       "1                                     =                              0.020   \n",
+       "..                                  ...                                ...   \n",
+       "7                                     =                             43.000   \n",
+       "8                                     =                            247.000   \n",
+       "\n",
+       "   ligand.bioactivity_standard_units  ligand.bioactivity_pchembl_value  \\\n",
+       "0                                 nM                             10.80   \n",
+       "1                                 nM                             10.70   \n",
+       "..                               ...                               ...   \n",
+       "7                                 nM                              7.37   \n",
+       "8                                 nM                              6.61   \n",
+       "\n",
+       "           species.chembl  ligand.klifs_id (query)  \n",
+       "0   Oryctolagus cuniculus                      100  \n",
+       "1           Gallus gallus                      100  \n",
+       "..                    ...                      ...  \n",
+       "7            Homo sapiens                      100  \n",
+       "8            Homo sapiens                      200  \n",
+       "\n",
+       "[9 rows x 11 columns]"
       ]
      },
      "execution_count": 82,
@@ -9186,7 +9528,7 @@
     {
      "data": {
       "application/vnd.jupyter.widget-view+json": {
-       "model_id": "88a3f355ac4b4d4e8fe1d800915f0861",
+       "model_id": "12660bc60d424e3486a178c04d6c0a14",
        "version_major": 2,
        "version_minor": 0
       },
@@ -9201,9 +9543,9 @@
      "name": "stderr",
      "output_type": "stream",
      "text": [
-      "ERROR:opencadd.databases.klifs.core:There was (were) 1/1 failed request(s).\n",
+      "There was (were) 1/1 failed request(s).\n",
       "Show error messages (up to 5 messages only):\n",
-      "ERROR:opencadd.databases.klifs.core:Error for 10000: Expected type to be dict for value [400, 'KLIFS error: Could not find a ligand with the provided ID.'] to unmarshal to a <class 'abc.Error'>.Was <class 'list'> instead.\n"
+      "Error for 10000: Expected type to be dict for value [400, 'KLIFS error: Could not find a ligand with the provided ID.'] to unmarshal to a <class 'abc.Error'>.Was <class 'list'> instead.\n"
      ]
     },
     {
@@ -9362,6 +9704,20 @@
    "execution_count": 85,
    "metadata": {},
    "outputs": [
+    {
+     "name": "stdout",
+     "output_type": "stream",
+     "text": [
+      "       structure.klifs_id                            interaction.fingerprint\n",
+      "0                       1  0000000000000010000000000000000000000000000000...\n",
+      "1                       3  0000000000000010000000000000000000000000000000...\n",
+      "...                   ...                                                ...\n",
+      "10518               13850  0000000000000010000001000000100000000000000000...\n",
+      "10519               13853  0000000000000010000001000000100000010000000000...\n",
+      "\n",
+      "[10520 rows x 2 columns]\n"
+     ]
+    },
     {
      "data": {
       "text/html": [
@@ -9487,25 +9843,34 @@
        "      <td>0000000000000000000000000000000000000000000000...</td>\n",
        "    </tr>\n",
        "    <tr>\n",
-       "      <th>2</th>\n",
-       "      <td>5728</td>\n",
-       "      <td>0000000000000010000000000000000000000000000000...</td>\n",
+       "      <th>...</th>\n",
+       "      <td>...</td>\n",
+       "      <td>...</td>\n",
        "    </tr>\n",
        "    <tr>\n",
-       "      <th>3</th>\n",
-       "      <td>5705</td>\n",
-       "      <td>0000000000000010000000000000000000000000000000...</td>\n",
+       "      <th>4</th>\n",
+       "      <td>13623</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
+       "    </tr>\n",
+       "    <tr>\n",
+       "      <th>5</th>\n",
+       "      <td>1243</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "    </tr>\n",
        "  </tbody>\n",
        "</table>\n",
+       "<p>6 rows × 2 columns</p>\n",
        "</div>"
       ],
       "text/plain": [
-       "   structure.klifs_id                            interaction.fingerprint\n",
-       "0                3482  0000000000000010000001000000000000000000000000...\n",
-       "1               12347  0000000000000000000000000000000000000000000000...\n",
-       "2                5728  0000000000000010000000000000000000000000000000...\n",
-       "3                5705  0000000000000010000000000000000000000000000000..."
+       "    structure.klifs_id                            interaction.fingerprint\n",
+       "0                 3482  0000000000000010000001000000000000000000000000...\n",
+       "1                12347  0000000000000000000000000000000000000000000000...\n",
+       "..                 ...                                                ...\n",
+       "4                13623                                               <NA>\n",
+       "5                 1243                                               <NA>\n",
+       "\n",
+       "[6 rows x 2 columns]"
       ]
      },
      "execution_count": 86,
@@ -10355,8 +10720,8 @@
      "name": "stderr",
      "output_type": "stream",
      "text": [
-      "WARNING:opencadd.io.dataframe:Suspicious residue ID: _0 (from QH1_0)\n",
-      "WARNING:opencadd.io.dataframe:Suspicious residue ID: _0 (from QH1_0)\n"
+      "Suspicious residue ID: _0 (from QH1_0)\n",
+      "Suspicious residue ID: _0 (from QH1_0)\n"
      ]
     },
     {
@@ -10404,7 +10769,7 @@
        "      <td>901</td>\n",
        "      <td>HOH</td>\n",
        "      <td>&lt;NA&gt;</td>\n",
-       "      <td>NaN</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>NaN</td>\n",
        "      <td>NaN</td>\n",
        "    </tr>\n",
@@ -10418,7 +10783,7 @@
        "      <td>901</td>\n",
        "      <td>HOH</td>\n",
        "      <td>&lt;NA&gt;</td>\n",
-       "      <td>NaN</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>NaN</td>\n",
        "      <td>NaN</td>\n",
        "    </tr>\n",
@@ -10446,7 +10811,7 @@
        "      <td>722</td>\n",
        "      <td>SER</td>\n",
        "      <td>&lt;NA&gt;</td>\n",
-       "      <td>NaN</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>NaN</td>\n",
        "      <td>NaN</td>\n",
        "    </tr>\n",
@@ -10460,7 +10825,7 @@
        "      <td>722</td>\n",
        "      <td>SER</td>\n",
        "      <td>&lt;NA&gt;</td>\n",
-       "      <td>NaN</td>\n",
+       "      <td>&lt;NA&gt;</td>\n",
        "      <td>NaN</td>\n",
        "      <td>NaN</td>\n",
        "    </tr>\n",
@@ -10478,11 +10843,11 @@
        "3603     3604        HG -31.812500  21.593599  37.191399        722   \n",
        "\n",
        "     residue.name  residue.klifs_id residue.klifs_region_id  \\\n",
-       "0             HOH              <NA>                     NaN   \n",
-       "1             HOH              <NA>                     NaN   \n",
+       "0             HOH              <NA>                    <NA>   \n",
+       "1             HOH              <NA>                    <NA>   \n",
        "...           ...               ...                     ...   \n",
-       "3602          SER              <NA>                     NaN   \n",
-       "3603          SER              <NA>                     NaN   \n",
+       "3602          SER              <NA>                    <NA>   \n",
+       "3603          SER              <NA>                    <NA>   \n",
        "\n",
        "     residue.klifs_region residue.klifs_color  \n",
        "0                     NaN                 NaN  \n",
@@ -10513,7 +10878,7 @@
      "name": "stderr",
      "output_type": "stream",
      "text": [
-      "WARNING:opencadd.io.dataframe:Suspicious residue ID: _0 (from QH1_0)\n"
+      "Suspicious residue ID: _0 (from QH1_0)\n"
      ]
     },
     {
@@ -10529,7 +10894,7 @@
      "name": "stderr",
      "output_type": "stream",
      "text": [
-      "WARNING:opencadd.io.dataframe:Suspicious residue ID:  (from QH1)\n"
+      "Suspicious residue ID:  (from QH1)\n"
      ]
     },
     {
@@ -10603,7 +10968,7 @@
      "name": "stderr",
      "output_type": "stream",
      "text": [
-      "WARNING:opencadd.io.dataframe:Suspicious residue ID: _0 (from QH1_0)\n"
+      "Suspicious residue ID: _0 (from QH1_0)\n"
      ]
     },
     {
@@ -10613,21 +10978,21 @@
       "Complex (mol2): Number of atoms: 3604\n",
       "Complex (pdb): Number of atoms: 1819\n",
       "Protein (mol2): Number of atoms: 3552\n",
-      "Pocket (mol2): Number of atoms: 1156\n",
-      "Pocket (pdb): Number of atoms: 1156\n"
+      "Pocket (mol2): Number of atoms: 1156\n"
      ]
     },
     {
      "name": "stderr",
      "output_type": "stream",
      "text": [
-      "WARNING:opencadd.io.dataframe:Suspicious residue ID:  (from QH1)\n"
+      "Suspicious residue ID:  (from QH1)\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
+      "Pocket (pdb): Number of atoms: 1156\n",
       "Ligand (mol2): Number of atoms: 49\n"
      ]
     },
@@ -10635,7 +11000,7 @@
      "name": "stderr",
      "output_type": "stream",
      "text": [
-      "WARNING:opencadd.io.dataframe:Suspicious residue ID:  (from HOH)\n"
+      "Suspicious residue ID:  (from HOH)\n"
      ]
     },
     {
@@ -10703,7 +11068,7 @@
      "name": "stderr",
      "output_type": "stream",
      "text": [
-      "WARNING:opencadd.io.dataframe:Suspicious residue ID: _0 (from QH1_0)\n"
+      "Suspicious residue ID: _0 (from QH1_0)\n"
      ]
     },
     {
@@ -10711,36 +11076,36 @@
      "output_type": "stream",
      "text": [
       "Complex (mol2): Number of atoms: 3604\n",
-      "Protein (mol2): Number of atoms: 3552\n"
+      "Protein (mol2): Number of atoms: 3552\n",
+      "Pocket (mol2): Number of atoms: 1156\n"
      ]
     },
     {
      "name": "stderr",
      "output_type": "stream",
      "text": [
-      "WARNING:opencadd.io.dataframe:Suspicious residue ID:  (from QH1)\n"
+      "Suspicious residue ID:  (from QH1)\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "Pocket (mol2): Number of atoms: 1156\n",
-      "Pocket (pdb): Number of atoms: 1156\n",
-      "Ligand (mol2): Number of atoms: 49\n"
+      "Pocket (pdb): Number of atoms: 1156\n"
      ]
     },
     {
      "name": "stderr",
      "output_type": "stream",
      "text": [
-      "WARNING:opencadd.io.dataframe:Suspicious residue ID:  (from HOH)\n"
+      "Suspicious residue ID:  (from HOH)\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
+      "Ligand (mol2): Number of atoms: 49\n",
       "Ligand (pdb): Number of atoms: 31\n",
       "Water (mol2): Number of atoms: 3\n"
      ]
@@ -10788,9 +11153,9 @@
    "outputs": [
     {
      "data": {
-      "image/png": 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\n",
+      "image/png": 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\n",
       "text/plain": [
-       "<rdkit.Chem.rdchem.Mol at 0x7f7ea81541c0>"
+       "<rdkit.Chem.rdchem.Mol at 0x7f0b6920efa0>"
       ]
      },
      "execution_count": 108,
@@ -10809,9 +11174,9 @@
    "outputs": [
     {
      "data": {
-      "image/png": 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\n",
+      "image/png": "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\n",
       "text/plain": [
-       "<rdkit.Chem.rdchem.Mol at 0x7f7ea7d317c0>"
+       "<rdkit.Chem.rdchem.Mol at 0x7f0b695bed60>"
       ]
      },
      "execution_count": 109,
@@ -10864,9 +11229,9 @@
    "outputs": [
     {
      "data": {
-      "image/png": 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\n",
+      "image/png": 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\n",
       "text/plain": [
-       "<rdkit.Chem.rdchem.Mol at 0x7f7ea8296d60>"
+       "<rdkit.Chem.rdchem.Mol at 0x7f0b695bea00>"
       ]
      },
      "execution_count": 111,
@@ -10885,9 +11250,9 @@
    "outputs": [
     {
      "data": {
-      "image/png": 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\n",
+      "image/png": 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AVFSkOzn1ZUwrENh5eER6ek41GKoqK0+Xl5/g/qtx/LMqEI55D2/O0fHuazu72lL0cbLKykpqaiQiUZD1HA6r1epLly7l5OTk5OQkJSVdu3atX79+EydO5HtcxOpRjPJKIHjSDL2HWv1jQcESQNS27ecCgT0AodDR2TnM2TmM20GnK9buOYjNR5CbixMnUFh4bxOXL6OmBlxFdvQowsLq0+/lqiq1Xu8lFjfNGC0pKbn8IHX38fLyGjBgAK0uSBqPzo1at/Lyk9euzZVKn/b3X1GvD+TlIS0NJ07gxAmcOoXoaLRujV9+QWQkzp3DmTPYu/exM0vzcnJm+Ps3hYN6nU6Xn5+fk5NjLDM55eXl9+8skUg63FFZWfnvf//bz8/v8uXLTk3gixCrRtWoddNq88rKjtjZPfRx6vcKDERgICZNAgDGwNViI0bg1CmMGgW5HNbwsLb09PT3338/JyfnypUrNTU19+/g5eXV4a86duzYsmXLuvucPHny5MmTn3/++ezZsy01cNI8UTVq3W7fVly9OqtFi+jAQIXFOj2oUvV2cfHi6XKo48ePL1myJDk5mXvr4eHRvo7u3bv37NmTe5zno+3YsePFF19s06bNpUuX7O3tzTxq0pxRNWrdeFmzuZ+Ly/AzZ9o4Ov7Ax3pIv/32W3Jy8gsvvLB69eoOHTo41p0ie5CSkpK6x/svvfQSt7j9+PHjg4KCMjMzv/rqq9dff90iYyfNE8WodeNlXRK1TscAvqZmMjMzAYwdO/b+Re3qM7Pk5+fHxahAIFiwYMHLL7/8r3/969VXXxU363sNiFnRHx3rdudBTBatRtU6HQA3ns6icjEaFBTEvU1PT1+1ahVXaVZUVNy/v7Ozc90zpAMHDjT+aNKkScuWLbtw4cJ33303depUy4yfND8Uo9btzkG9ZatRvR6AGx/lm06ny87OFggEPXv25LZUV1fv3LmTe33PeVJO27ZtH/aYT5FIJJPJoqKiVq1aNWXKFHoaKGkYilHrVlzcBRio17d+/K6mw1WjrnzE6MWLF6uqqtq3b+96ZxWVXr16JSYmcsWmm5vboz9+v7/97W8rVqw4f/78jh07XnrpJVOPl9gE+ufXur32WlxoaOqtW8GP39V0ag/q+YjRs2fPAujVq5dxi1QqjYyM7NevXwMyFICdnd28efMArFy5kq5aIQ1DMWrdlErgwTfim1HtQT0f50a5E6N1Y7TxoqKiWrVqdfr06b1795qwWWI7KEatG7eunoVjtJTvatQ4v2QSDg4O7777LgBusRJCnhTFqBXTaKDVQiqFhS8e5/HcqFj8Zt++c4OC+pi22ZkzZ/r4+KSlpR04cMC0LRNbQDFqxXg5ogegO3KkU3a2q0pl4X7VauzaNfKPP9Z07NjRtC1LJJJ33nkHwKpVq0zbMrEFFKNWrLgYACz/DKEDa9dufeUV+wct1G9WZ8+CMfTsaZb7/mfPnu3h4XHo0KGjR4+avnXSrFGMWjG+qlGlUgnA8s+AO3sWAEw6vXSXq6sr90SmDz74wCwdkOaLYtQ6XLoEw51F7PPzUV6O339HcDAOH8bKlTh3zqKDKS4uBuBp8fzOzAQAk04v/UVMTIxUKv3pp59Onjxprj5Ic0Qxah0mToRGU/t63jxkZCAkBNu24emnERKCyEjLjUSr1ZaVldnZ2bm4uFiuVwB3qlHzxainp+ebb74JKkjJE6IYtVY9e+I//8GtW5bu13hEb+F14xmrLbrNF6MA/vnPf0okkl27dnFXVhFSHxSjVmPDBnz8MT7+GBcuAICDAxYvxty5lh4Gd0Rv+ROjubkoLYW/P7zrvUR1fRgMhpiYmP3793NvfXx8ZsyYwRhbsmSJXq83ZU+k+aIYtRpdu6J7d3TvDuNNj+PHo6QEhw9bdBhcNWr5E6PmmF/S6/VRUVHr1q2bOnWq5s5Jk3HjxtnZ2aWmpvr6+k6aNGnz5s03btwwZa+k2aEYtRrDhmHECIwYAT+/uxs//RQLFwJAWho++wwWuCmcr2pUqYRUijvrOpmATqd77bXXEhISnJ2dt27dKpVKAaSnp0+cOLGmpqampkapVG7btm3mzJlt2rQZNGjQypUrMzIy6L578gCMWIPevZlKVft68mR25AgLDq59u3Qp69qVdenCADZyJLt2zYzDyMjICA8Pd3d3b9eu3fXr183YUx07d7IjRxhjzGBg27axggITtFldXT1hwgQAbm5uv/32G7fx6NGj3Pomo0ePrqysvHjx4ieffDJ8+HAHBwfj3xc/P7933924bdvd/x2EUIxah5MnmU5X+/rcOaZSsbS02reVlSw1lSUmshYtGMDc3JhCYfoBHDp0KCIigosSZ2dnAB4eHl9//bXpe7rPpEmsfXtWUsIYY1On3v3iDVZeXv7cc89xXyHtTnO//vorV5BOnjxZq9XW3b+ioiI5OTkmJiYgIADAkCGHACYSseBgFhvL0tOZwXB35+vXWX5+7euCAqZUNna0pOmjGG0+bt5k48czgAHshReYqYrFlJSUYcOGcQEqlUpjYmLOnj07btw4bsuoUaPMXZZOmsQWLWJvvsmYKWK0rKyM+zq+vr5nzpzhNu7du5d7zPLUqVNramoe8fGzZ8+uW6ccMoSJxbW/1QALDGSzZrGkJFZezhYvZgEBTKNhjLGlS5lF/qEhPKMYbW4SE5mnJwOYtzf7/vuGt2MwGJKSkgYMGMDFpZeXV2xsbHFxcZ2OEj08PAB4e3t/35ieHmfSJJaZyZ55hqWlNTZGS0pKuIeItGzZMisri9uYlJTEHbbPnDlTr9fXuymWmMhee435+t7NUycn9u67bMIENncuYxSjNoNitBnKy2MREbV/sWfNKlU+4YGlXq9PSkoKDq5dCtrb2zs2Nlb1oHOBeXl5xiP9yMjIoqIiE30DxhgzGNiOHey772pjNCuLDRrEpkxhaWns22/ZXw+766W4uDg0NBRAYGDgpUuXuI3ffvutnZ0dgLlz5xrqHpw/iawsJpeziAgWHMwWL2bbt7PwcHbmDMWoraAYbZ4MBqZQMFdX1rt3jK+v786dO+vzKb1en5iY2LVrVy4Z27RpEx8fX1FRYdzh9OnTt2/f/mtHBoVCwd3R5Ofnt2vXrsYPXq9nSUmsXz8GsJYt2UsvscxMxhibN495eLC4OAawgACmUNw9X/xYN2/e5FYp7dy5c/6dk5dfffWVSCQCIJPJGj9sxlh1NVu8mP3wA/v9d/b00xSjtoJitDnLySl+6qmnuEx8/fXX1Wr1w/asrq5OSEjo1KkTt3Pbtm3j4+MrKyuNO5w6dSoyMlIgEMyfP//+j1++fHnIkCHGsrTusf8T0WrZF1+wzp1rS+mAALZ+PXv1VZadzRhjGg3r2pVt3Mi6davdoW9ftm/f45u9evUq99W6detmPJO7ceNG7hl2y5Yta9hoH4iLUcbYW2+xoCCKUZtAMdrMcdWiRCIBEBAQ8Msvv9yzQ1VVlUKhaN269qF4HTp0UCgUdadZjhw5ws1rc3P077///mM7CgwMPHDgwBONs7qaJSSwjh1r87FdOxYfz+rE+F/o9SwxkbVrV7vzoEEsJeWhLefm5nbo0AFA3759jaX06tWrAQgEgk8++eSJxvlYxhhVq5m/P8WoTaAYtQnZ2dn9+/fngiM6Olqj0TDGNBpNfHx8y5YtuYgMCgpKSEjQ1TlOTklJGT16NPdTFxeXmJiYgsddtHnu3Ln7O3q08vLyzZtT/P1rM7F7d/b11/U6Wq+uZgoF8/Gp/WBEBDt79gG7paSkSCSSgQMHlnDXTDEml8u5Ea5fv/7x3Tyh69drr83Kz2effUYXPNkEilFbUVNTs2LFCnt7ewDt27d//fXXjTd0DhgwICkpqe4ES3JyclhYGPdTV1dXmUxW/3mqmpoauVzOddSuXbvDhw8/bE9jjotE9m3banv1YgkJT3C6804jTC5nUikD2DPP7I+MjMzNzb1nn2PHjhkDffHixQBEItGWLVuerKcnUVnJHByYUMgaenqDWBOKUduSmZnZr18/4yX04eHhSUlJxp9yc/QhISGPnaN/rLNnz/bt2xeAUCiMiYmpqqqq+1OlUhkbG8tdLwUgLCxs//6shs6TM8bY9evs7be1UqkvAIlEMn/+fGPtaWQwGObMmQPA3t5+27ZtDe+sfp56igFs925z90P4RzFqc6qrq7k74hMTE40buTn6bt26cbnm6+srl8vLy8sb05FWq5XL5dzlRN27dz958iRjrLCwMDY21t3dnevonhxvpAsXLnDzYNwdSnK53HiZgU6ni4qKAuDg4LBjxw5T9fgIixYxoPYCUtK8UYzaIq4UNR7nlpSUtG/fnsu1du3abdq06Z7isTGOHTvWpUsXAHZ2duHh4dwcFIARI0YcPXrUVL3UdeLECeNtV61atVIoFFVVVa+88gpXqP7888/m6JRz8iT7179q7x/7+WcGsJAQ8/VGmgqKUZtTXV3NHdjW3fj888+3b9/+njl6U6msrJTJZAKBoFWrVgKBYPTo0WmNvzH+cfbv38+dvgDALTji6uqa8ogZfVMYM4YBLCGBMcbKy5m9PROJaBGT5o9i1OYUFBRwd0PW3VhYWFj/+yAbJjw8HIA5JscfxmAwJCYmdujQoXXr1lKp9NixY+bu8cMPGcCiomrfDhzIALZ3r7m7JTyj9UZtzgPXXfb29uauRTcfnU4HwHiPqQUIBILIyMjTp08XFRWVlZWZ/On29xs6FMDdhbS5OxIsvK42sTyKUZtjsXWXs7Ozt2/ffoF75gl/zxN1cXEJCwtjjFngAfR9+sDdHTk5yM8HKEZtBsWozbHYU0B27do1ceLEhISEuv1aftl8ANyNqofNn2ciEQYNAoCUFAAID4e9PdTqqrKySnN3TXhEMWpzLBZndctPg8GgUqmEQqHxUidLsliMAhgyBEIhMjI0AKRSDBo07vx5p9TUFAt0TfhCMWpzLHZwXbfsValUBoPB3d2dW1HJwgYOHOjo6HjmzBmVSmXuvp59NkcqbbtnT3/ubUhIZwBHjhwxd7+ERxSjNsdi50brlr18PU+U4+joGBISYjAYLHJ6NNBgKL5w4QJ3RQRXCP/666/m7pfwiGLU5lgs0eqWvTyeGOUMHToUFjmuF4vF3AL7XGQPHjxYJBKdPHmyoqLC3F0TvlCM2hxeqlG+pumNLFkV1j0V6+bm1rt3b61We/z4cQt0TXhBMWpzLFyN1j2o57EaHTRokL29/alTp9Rqtbn7umdGy5ITXIQXFKM2x2KJVlJSAoBbxon3alQikQQHB+v1+tTUVHP31b9/f2dn5+zs7MLCQlCM2gCKUZtjmUQrLS3VarVSqZRbeNRiZxIewWJxZm9v/8EHH2zdupVbAmbw4MFCofD48eNVVVXm7prwgmLU5lgmRu/JTX5n6jmWrApjYmImTZrExainp6e/v79erx87duyWLVtu3bplgQEQSxLzPQBiUeXl5VVVVRKJxMnJyawd3ZObTaEafeqpp8RicXp6ukajkUqllumUMfbOO+9cu3bN1dU1OTk5OTkZQPfu3ceMGRMRETF06FCxmP4OWj2qRm2Lha+9b1LVqIuLS9++fXU6ncUmzRljb7/99tq1a+3t7ePi4jZs2DBq1CiJRJKdnR0XFzd8+HB/f/9p06Z9++3W4mLLjIiYBcWobeHlTlBL9vtoljyu1+v106dP37Bhg0Qi2b1796xZs9588809e/Yolcrk5GSZTNatW7fbt29//fXXS5f+4OODkBDMn4+jR8GYBUZHTIli1LY88OCam1A2rXtyk/eZeo7FYlSr1f7f//1fQkKCs7Pz7t27jU+oBuDo6BgRESGXy7Ozs//444+PP/546NDZYjF+/x1xcRg8GK1bY8YM/PADNBoAOHgQISG1r48cwbJleOcdnDlT29ratdixw9zfhjwGxahtuf/g+sqVK506dZo5c2ZZWZkJO2qa1Sh3T9GJEyfMek9RdXX15MmTv//+e3d39+Tk5GefffZhe0AhkYcAAAczSURBVHbp0uUf//iHQjGkqAg7dmDGDLRujYICfPYZXnoJLVpg2DBkZkKjQWwsAFRUQKnEzZswzvkXF6O01HxfhdQLxaht4dKNe+gbJzU1tbKycvPmzf369TPhNZWDBw9etGgRV/3pdDqNRiMWi11dXU3VfsM88J6i/Pz8sLCw5cuXp6enGwyGRnZRUVExZsyYnTt3enp6/vzzz9yNoY/l4oLx47F5M/LzkZOD+HhERIAxHDwIiQTjx+PUKZw6dXf/GzeQm4vcXJh/rRVSDzyvvk8s68KFCyNGjBCJRDKZTKvVchszMzOND0OOjo5u5ANB78dd4uPj42PaZhvmH//4B4AlS5YYt2zatMn416FFixaRkZEJCQnFDXrAvEajeeaZZwD4+vqePXu2kUMtLmZJSSwpiclk7PRpFh7O9u5lb7/NJk9m48ez6GgWHc2Cg9mWLY3shzQWxajNiYmJ4arR0NDQ7OxsbuMDH4ZsKtnZ2QC6du1qwjYbbOfOnQCGDBli3FJRUcHN+XBPMOWIRKLg4ODY2FiuRK1PyyUlJWFhYQDatGlz8eJFUw2Yi1HG2DvvsClTamP0+PHan8bGUozyj2LUFqWkpHTo0AGAo6OjXC7X6XTc9rS0tK5duwIQi8Uymay6utok3X300UcAOnfubO6n5tWHUqkUCoV2dnZHjhy5fzw5OTnx8fERERHczVccX1/fadOmJSYmqtXqhzV769at3r17A2jbtu2lS5dMOGBjjKrVrFWrB8fod9+xdeuY6Z6KTZ4MxaiNUqvV0dHRXFk6cODACxcucNu5hyFziysHBQVlZGQ0uAuDwZCUlBQaGoo7d9YPGjTIhGVagy1atCggIACAl5dXZGSkQqG4cePGPfuo1ervv/8+KiqqZcuWxjx1cHAYPnz4tWvX7tn5xo0bPXv2BNClS5f8/HzTjjY7++6zRX/5he3axbZsYVeu1G756Se2fz87dozt3s3++1/T9kzqi2LUpu3bt69169YAnJyc5HK5sTr77bffOnXqBMDOzi42NtZYrtaTTqf79ttvg4KCuPTx8/OLiory9fUF4OLisnHjxnoeJpuJXq9/66232rdvX/cQPjw8fNWqVRkZGfePLSsrSy6XR0RE2NnZSaXSe4r0vLw87veqe/fuBQUFFvwef/HZZ+zgQb46t3UUo7aupKQkOjqaS5OIiIi8vDxue3l5uUwm4566PGDAgPPnz9enNa1Wm5CQwJ0ZABAQEBAfH19RUXFPR8OHD7969aoZv1X95OTkKBSK0aNHOzg4GCPVx8eHO4QvKSm5Z/+ioqLDhw/X3ZKbm8vFcb9+/W7fvm3Bsf/Fvn3s3//mq3NCMUoYY4zt2bOHO3p1dXVVKBTG7fv37+fKVYlEsmfPnke0UF1dnZCQwNVl3CnC+Pj4ysrKe3bbtm2bt7f3/R3xq7y8PDk5OSYmpk2bNveUqHK5/GGzTOfPn2/VqhWA8PBwlUpl+WFzzpxhzz3HZDL20098DcHWUYySWrdu3XrxxRe5BBkxYoTxDCB3FrVFixY3b9584AerqqoUCgWXtgA6dOigUChqamoe1tHNmzfHjRvH7TxmzJgbD2mWLw+cZWrbtm10dHRiYmJpaSm3W1ZWFvcPz5AhQ4wbiW2iGCV/kZiYyN1r5O7uXrdafGCGajSa+Ph44yRMUFBQQkJCPU+kJiYmenp6evj7v3j69Hb+Docfobi4eOvWra+88oqPj48xT52cnEaMGPHee+9xN2iNHDmSO2VBbBnFKLnXjRs3xo4dy6XGxIkTH3jKT61Wy+Vy472effv2TUxMfNKJo/z8/PdTUoLT04PT0+fn5KgeXsDyzjjLxK1rJxQK7e3tX3zxRVNdE0asmoDRejLkQb788su33npLo9H4+Phs2rRpwoQJ3Pbbt29v2LDh008/5Z75Hh4eLpPJxowZ0+COflQq4/LzK/R6T7F4QWDgM+7upvkC5lFYWLhv374///xz9OjRwcHBtFooAUAxSh4qLy8vKirq4MGDACIjI1esWPHFF1+sW7eOW9cjPDx82bJlw4YNa3xHN7TaZVeupGs0ACI8PBYGBLhSPBHrQTFKHsVgMKxfv37BggUVFRWOjo5VVVUCgWDs2LGLFy8OCQkxYUcM2FFU9El+fqXB0MLOblFgYDeJ5Gp1NffTQAcHLzs7E3ZHiAlRjJLHu3jx4pw5c7p163bjxo2FCxcar6s3ubyqqqVXrmSWlwuAcd7ehdXVQS4uAAa7uXWVSMzUKSGNRDFKmhYD8F1h4W6lcrSXFxh72deX7xER8hgUo6Qp0jO2vajol5ISrgh909/fUUhr45Imik7kk6ZIJBAA6CGRjPT0BGBfZ51pQpoailHSdHnb2XWmU6KkyaMDJUIIaRQ6N0qaKLVOxwB3uoCUNHkUo4QQ0ih0UE8IIY1CMUoIIY1CMUoIIY1CMUoIIY1CMUoIIY3y/9GBhfUHBxwGAAADDnpUWHRyZGtpdFBLTCByZGtpdCAyMDIxLjAzLjMAAHicnZVLaNRAGMcnk91ks5vss/tud2OxpfVRs90+0XZjC3Wx0FoqrfUgAVEjpQfFSqUIFR8tWAqCClV6EhGEgqj4QOwG8eDjIkXoQS148OYLK1JQ0OSb9OAtnYGZ/DPM7z8z33yTfFuYX0ZmEc3KIFKyZq006wTDddSYT9a11WU+5M5czhpSZzXbrEZWWLPtK5L+nfXQlycm3wuNTCvXoVs8y6wZ5MEAr8Pg/wU0AM9S843Au5zzWLMCw9q8QgLgXieP8RoPI+o4ap7Ej6fdv9ICvIeabwVeoI5/E/Be+gRqBgMfvQGJgEi9AxIBiZbPkwzwU28gT1IgQG9A7kCQ3oCcQYg6BOQIwtQLaFDAIEJvQK5xmWMDAcumtPGuHJk/SonnSQrFHOM8huVj26BHIQcQd25ADsD+ivXkSA4maPl6sv/kejfA4DUDEv8U7QLy5DeQpubJZ6jcMe/B1v/wr30AvQq5QhXUPJk/45gP4i1WArntK9SvkABkHRv4kEdDIR2juMxgHTNxDbMalmRW0DGb0Fxu5OYQl0G8R8d8RONjsqcMCV5NiGten459oiYmdCwmZcmvYymo+VNaIKXjQFoLpnUcCmuhKApHdBzLoEy5i6nIoDKXm8GsEOf4SDiEPJzXJyZYgfOnAumgFGeQXbIT6YulqeY3JeulKPCFD79RwdK+90idHGkEPfJwkzpUvRHGtF3rNa6PXlIt/WV6wLi9uRP0ythVo7gnCRodGjZWqx7BeB5FjSPLRdD7V18VorEl0NLX1cKMUTQsvWF+nzp34iDo3M8ZtXZFBn2/uk4dQJj4i5PqdNINmj1wTpVvXgE98OdXITbdD/ojmi31vdsF7NFPlca9B8dA3xk8bkwtbgc9KPmN19km2Ne90R1t46XT0H9jeM7oepKAtT17fKF9ijkF+vnJs2r3+CTo9sBTteUW8SnenVMnFoZg3rcvatTzicugvVV7jdqx3eAfWnxpLHFnQHf/mDU+dxwGHfsHKpgyovzg+NsAAAIqelRYdE1PTCByZGtpdCAyMDIxLjAzLjMAAHicnVbLrtQwDN33K/IDjWzHceIlusNDQlwkkPgHVmy4/4/TZNIMAmnqUaXxqetTv1N5e/sV322h/b7dPv/8HeaPbtsWEobEIcA/L1UNPwgAmv2OEarULglJaRwQTQvhJfyPYr22bpGp5CFBqj4WioDN72ZboDp9oShSGssOURjJxbKnSNzj4Jg5i5clZToiShFYs4+FLRuUemxJs5MlRSkVeqUtNF92d/OAKvbslsq+vASMueYyuq4Ce1mUufbYMImz66xG9aivseTM4GPhyFJSz1BGdk9AIcQxCwmT1xciGP0CRZ1zxC2nuUtSxF8jUhl5huxjsS5BzWlUmsiX3VYZvrOU4uyXZltFOp8mds8RoY7pKYhrXj5c2bvAAt0rlYeue57F9ouijo2ZVdaZfr3iC0kam0ELFR+LdR1U6jUHWxI+lhwV+pZqNSL0+qJ0bEzrXR4b+DqLnUfp2AxtjgbfZZZ2ksytUhR0Yfn6PIvYDIr2uQR48OUCC8dqReq2VR9Ote/PslhJzA++A6wLaCcmdmCdkKaGDs0A/fYEeNpwQJgaDpQnMEnmYyaVCUr7ZrqDuvpWA8EK0nxMA00be2Pb23wHp6N2u32DDEABZzwmnb41MH2zYPDUGCgT5EAnkL/ATKIZLKAG1AUQzffoEpxFdubAJNIDoAE4NV9CePn08ShMe2C3m6a2/6Z5/3rb/gCsraU1rdy4rQAAAX16VFh0U01JTEVTIHJka2l0IDIwMjEuMDMuMwAAeJwlkr1q7TAQhF8lpQ2y2P9dkSZwIGVuccuQyv15gjx8ZnUwCHvQNzsa+fF4fP//+Pg5vv9dP+dr/br5Pj7P+7iecmO99X7i0RMvEO7j63zio7fc/PZ7XDrFNNew6ebB4x2KuqgPnWTLDYrNJJEYMnW5y1aKqXTQrLXM1wtjy4CUi2oFpJhKUWvwJCp6cYuXrnHR9BVBtcHIIhsXT9OKBjFIirW3ZVmYbU14+fZnNlFI8C2wTYZEIAVNCWWNJldKVEsuaeUAnbQMoExitU6fVElbSWFmnJCUJce7TRFSbSFX2yC5FDFaMXThLWCOFYqLDOP2CMXIFiQXwjCQ5QVEyV9zI9K8w4EQ7i1envsARYjdjHWLaAX2iTmgy3uPTndtX5sWqTxQibMVyvGJynkrS4V2XNwPYnZHXpjZbaE/tW0tghmohiyIaZsvHIZ3z/gRmtSZ2e32DWXfy3a3lHH+/gE2D4NjbSv2XgAAAABJRU5ErkJggg==\n",
       "text/plain": [
-       "<rdkit.Chem.rdchem.Mol at 0x7f7ea6700e20>"
+       "<rdkit.Chem.rdchem.Mol at 0x7f0b695be940>"
       ]
      },
      "execution_count": 112,
@@ -10913,9 +11278,9 @@
    "outputs": [
     {
      "data": {
-      "image/png": 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\n",
+      "image/png": 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\n",
       "text/plain": [
-       "<rdkit.Chem.rdchem.Mol at 0x7f7ea67009a0>"
+       "<rdkit.Chem.rdchem.Mol at 0x7f0b6925a6a0>"
       ]
      },
      "execution_count": 113,
@@ -11065,7 +11430,7 @@
  ],
  "metadata": {
   "kernelspec": {
-   "display_name": "Python 3",
+   "display_name": "Python 3 (ipykernel)",
    "language": "python",
    "name": "python3"
   },
@@ -11084,4 +11449,4 @@
  },
  "nbformat": 4,
  "nbformat_minor": 4
-}
\ No newline at end of file
+}