diff --git a/admet_ai/resources/data/admet.csv b/admet_ai/resources/data/admet.csv index 5f3ddbf..cb6a108 100644 --- a/admet_ai/resources/data/admet.csv +++ b/admet_ai/resources/data/admet.csv @@ -1,50 +1,50 @@ -category,id,name,size,task_type,units,species,tdc_rank,AUPRC,AUROC,R^2,MAE,url -Physicochemical,molecular_weight,Molecular Weight,,regression,Dalton,-,,,,,,https://www.rdkit.org/docs/source/rdkit.Chem.Descriptors.html#rdkit.Chem.Descriptors.MolWt -Physicochemical,logP,LogP,,regression,log-ratio,-,,,,,,https://www.rdkit.org/docs/source/rdkit.Chem.Crippen.html#rdkit.Chem.Crippen.MolLogP -Physicochemical,hydrogen_bond_acceptors,Hydrogen Bond Acceptors,,regression,#,-,,,,,,https://www.rdkit.org/docs/source/rdkit.Chem.rdMolDescriptors.html#rdkit.Chem.rdMolDescriptors.CalcNumHBA -Physicochemical,hydrogen_bond_donors,Hydrogen Bond Donors,,regression,#,-,,,,,,https://www.rdkit.org/docs/source/rdkit.Chem.rdMolDescriptors.html#rdkit.Chem.rdMolDescriptors.CalcNumHBD -Physicochemical,Lipinski,Lipinski Rule of 5,,regression,# of 4,-,,,,,,https://en.wikipedia.org/wiki/Lipinski%27s_rule_of_five#Components_of_the_rule -Physicochemical,QED,Quantitative Estimate of Druglikeness (QED),,regression,-,-,,,,,,https://www.rdkit.org/docs/source/rdkit.Chem.QED.html#rdkit.Chem.QED.qed -Physicochemical,stereo_centers,Stereo Centers,,regression,#,-,,,,,,https://www.rdkit.org/docs/source/rdkit.Chem.rdMolDescriptors.html#rdkit.Chem.rdMolDescriptors.CalcNumAtomStereoCenters -Physicochemical,tpsa,Topological Polar Surface Area (TPSA),,regression,Å^2,-,,,,,,https://www.rdkit.org/docs/source/rdkit.Chem.rdMolDescriptors.html#rdkit.Chem.rdMolDescriptors.CalcTPSA -Absorption,HIA_Hou,Human Intestinal Absorption,578,classification,-,human,2,0.996606708,0.980679753,,,https://tdcommons.ai/single_pred_tasks/adme/#hia-human-intestinal-absorption-hou-et-al -Absorption,Bioavailability_Ma,Oral Bioavailability,640,classification,-,human,5,0.898285256,0.783118134,,,https://tdcommons.ai/single_pred_tasks/adme/#bioavailability-ma-et-al -Absorption,Solubility_AqSolDB,Aqueous Solubility,9982,regression,log(mol/L),-,1,,,0.814276627,0.673885697,https://tdcommons.ai/single_pred_tasks/adme/#solubility-aqsoldb -Absorption,Lipophilicity_AstraZeneca,Lipophilicity,4200,regression,log-ratio,-,1,,,0.746047462,0.430572678,https://tdcommons.ai/single_pred_tasks/adme/#lipophilicity-astrazeneca -Absorption,HydrationFreeEnergy_FreeSolv,Hydration Free Energy,642,regression,kcal/mol,-,-,,,0.919245,0.71341,https://tdcommons.ai/single_pred_tasks/adme/#hydration-free-energy-freesolv -Absorption,Caco2_Wang,Cell Effective Permeability,906,regression,log(10^-6 cm/s),human,5,,,0.744364201,0.300075312,https://tdcommons.ai/single_pred_tasks/adme/#caco-2-cell-effective-permeability-wang-et-al -Absorption,PAMPA_NCATS,PAMPA Permeability,2034,classification,-,artificial membrane,-,0.94826615,0.798405536,,,https://tdcommons.ai/single_pred_tasks/adme/#pampa-permeability-ncats -Absorption,Pgp_Broccatelli,P-glycoprotein Inhibition,1212,classification,-,human pgp / mouse cells,10,0.959242927,0.945843699,,,https://tdcommons.ai/single_pred_tasks/adme/#pgp-p-glycoprotein-inhibition-broccatelli-et-al -Distribution,BBB_Martins,Blood-Brain Barrier Penetration,1975,classification,-,human,11,0.978083609,0.93934044,,,https://tdcommons.ai/single_pred_tasks/adme/#bbb-blood-brain-barrier-martins-et-al -Distribution,PPBR_AZ,Plasma Protein Binding Rate,1614,regression,%,human,3,,,0.462089051,7.754102431,https://tdcommons.ai/single_pred_tasks/adme/#ppbr-plasma-protein-binding-rate-astrazeneca -Distribution,VDss_Lombardo,Volume of Distribution at Steady State,1111,regression,L/kg,human,10,,,-0.610145027,5.890426238,https://tdcommons.ai/single_pred_tasks/adme/#vdss-volumn-of-distribution-at-steady-state-lombardo-et-al -Excretion,Half_Life_Obach,Half Life,665,regression,hr,human,7,,,-1.551572848,31.04670644,https://tdcommons.ai/single_pred_tasks/adme/#half-life-obach-et-al -Excretion,Clearance_Hepatocyte_AZ,Drug Clearance (Hepatocyte),1020,regression,uL/min/10^6 cells,human,4,,,0.302233775,31.562803,https://tdcommons.ai/single_pred_tasks/adme/#clearance-astrazeneca -Excretion,Clearance_Microsome_AZ,Drug Clearance (Microsome),1102,regression,uL/min/mg,human,2,,,0.300325493,25.2952124,https://tdcommons.ai/single_pred_tasks/adme/#clearance-astrazeneca -Metabolism,CYP1A2_Veith,CYP1A2 Inhibition,12579,classification,-,human,-,0.934630479,0.941599044,,,https://tdcommons.ai/single_pred_tasks/adme/#cyp-p450-1a2-inhibition-veith-et-al -Metabolism,CYP2C19_Veith,CYP2C19 Inhibition,12665,classification,-,human,-,0.882382711,0.907060295,,,https://tdcommons.ai/single_pred_tasks/adme/#cyp-p450-2c19-inhibition-veith-et-al -Metabolism,CYP2C9_Veith,CYP2C9 Inhibition,12092,classification,-,human,4,0.809011378,0.905095011,,,https://tdcommons.ai/single_pred_tasks/adme/#cyp-p450-2c9-inhibition-veith-et-al -Metabolism,CYP2D6_Veith,CYP2D6 Inhibition,13130,classification,-,human,3,0.734222423,0.887889936,,,https://tdcommons.ai/single_pred_tasks/adme/#cyp-p450-2d6-inhibition-veith-et-al -Metabolism,CYP3A4_Veith,CYP3A4 Inhibition,12328,classification,-,human,3,0.881595257,0.914678766,,,https://tdcommons.ai/single_pred_tasks/adme/#cyp-p450-3a4-inhibition-veith-et-al -Metabolism,CYP2C9_Substrate_CarbonMangels,CYP2C9 Substrate,666,classification,-,human,4,0.3002083,0.695313349,,,https://tdcommons.ai/single_pred_tasks/adme/#cyp2c9-substrate-carbon-mangels-et-al -Metabolism,CYP2D6_Substrate_CarbonMangels,CYP2D6 Substrate,664,classification,-,human,3,0.573863564,0.768020178,,,https://tdcommons.ai/single_pred_tasks/adme/#cyp2d6-substrate-carbon-mangels-et-al -Metabolism,CYP3A4_Substrate_CarbonMangels,CYP3A4 Substrate,667,classification,-,human,7,0.701417532,0.714367012,,,https://tdcommons.ai/single_pred_tasks/adme/#cyp3a4-substrate-carbon-mangels-et-al -Toxicity,hERG,hERG Blocking,648,classification,-,human,4,0.925968621,0.858940863,,,https://tdcommons.ai/single_pred_tasks/tox/#herg-blockers -Toxicity,ClinTox,Clinical Toxicity,1459,classification,-,human,-,0.425390242,0.869768917,,,https://tdcommons.ai/single_pred_tasks/tox/#clintox -Toxicity,AMES,Mutagenicity,7255,classification,-,salmonella typhimurium,2,0.912265988,0.892359338,,,https://tdcommons.ai/single_pred_tasks/tox/#ames-mutagenicity -Toxicity,DILI,Drug Induced Liver Injury,475,classification,-,human,5,0.858379277,0.865054697,,,https://tdcommons.ai/single_pred_tasks/tox/#dili-drug-induced-liver-injury -Toxicity,Carcinogens_Lagunin,Carcinogenicity,278,classification,-,rodent,-,0.728486215,0.839515637,,,https://tdcommons.ai/single_pred_tasks/tox/#carcinogens -Toxicity,LD50_Zhu,Acute Toxicity LD50,7342,regression,log(1/(mol/kg)),rat,5,,,0.612500001,0.436945841,https://tdcommons.ai/single_pred_tasks/tox/#acute-toxicity-ld50 -Toxicity,Skin_Reaction,Skin Reaction,404,classification,-,mouse,-,0.867316907,0.817321607,,,https://tdcommons.ai/single_pred_tasks/tox/#skin-reaction -Toxicity,NR-AR,Androgen Receptor (Full Length),6758,classification,-,human,-,0.620952705,0.821381643,,,https://tdcommons.ai/single_pred_tasks/tox/#tox21 -Toxicity,NR-AR-LBD,Androgen Receptor (Ligand Binding Domain),7265,classification,-,human,-,0.711622503,0.899019067,,,https://tdcommons.ai/single_pred_tasks/tox/#tox21 -Toxicity,NR-AhR,Aryl Hydrocarbon Receptor,6549,classification,-,human,-,0.62899255,0.887560753,,,https://tdcommons.ai/single_pred_tasks/tox/#tox21 -Toxicity,NR-Aromatase,Aromatase,5821,classification,-,human,-,0.453731846,0.874020253,,,https://tdcommons.ai/single_pred_tasks/tox/#tox21 -Toxicity,NR-ER,Estrogen Receptor (Full Length),6955,classification,-,human,-,0.451886067,0.715059484,,,https://tdcommons.ai/single_pred_tasks/tox/#tox21 -Toxicity,NR-ER-LBD,Estrogen Receptor (Ligand Binding Domain),6193,classification,-,human,-,0.469083765,0.814587495,,,https://tdcommons.ai/single_pred_tasks/tox/#tox21 -Toxicity,NR-PPAR-gamma,Peroxisome Proliferator-Activated Receptor Gamma,6450,classification,-,human,-,0.373228274,0.884272416,,,https://tdcommons.ai/single_pred_tasks/tox/#tox21 -Toxicity,SR-ARE,Nuclear Factor (Erythroid-Derived 2)-Like 2/Antioxidant Responsive Element,5832,classification,-,human,-,0.548436893,0.837783074,,,https://tdcommons.ai/single_pred_tasks/tox/#tox21 -Toxicity,SR-ATAD5,ATPase Family AAA Domain-Containing Protein 5 (ATAD5),7072,classification,-,human,-,0.324797882,0.879084144,,,https://tdcommons.ai/single_pred_tasks/tox/#tox21 -Toxicity,SR-HSE,Heat Shock Factor Response Element,6467,classification,-,human,-,0.380343661,0.852138257,,,https://tdcommons.ai/single_pred_tasks/tox/#tox21 -Toxicity,SR-MMP,Mitochondrial Membrane Potential,5810,classification,-,human,-,0.744683945,0.925379251,,,https://tdcommons.ai/single_pred_tasks/tox/#tox21 -Toxicity,SR-p53,Tumor Protein p53,6774,classification,-,human,-,0.408814321,0.878568992,,,https://tdcommons.ai/single_pred_tasks/tox/#tox21 \ No newline at end of file +category,id,name,size,task_type,units,minimum,maximum,species,tdc_rank,AUPRC,AUROC,R^2,MAE,url +Physicochemical,molecular_weight,Molecular Weight,,regression,Dalton,0,inf,-,,,,,,https://www.rdkit.org/docs/source/rdkit.Chem.Descriptors.html#rdkit.Chem.Descriptors.MolWt +Physicochemical,logP,LogP,,regression,log-ratio,-inf,inf,-,,,,,,https://www.rdkit.org/docs/source/rdkit.Chem.Crippen.html#rdkit.Chem.Crippen.MolLogP +Physicochemical,hydrogen_bond_acceptors,Hydrogen Bond Acceptors,,regression,#,0,inf,-,,,,,,https://www.rdkit.org/docs/source/rdkit.Chem.rdMolDescriptors.html#rdkit.Chem.rdMolDescriptors.CalcNumHBA +Physicochemical,hydrogen_bond_donors,Hydrogen Bond Donors,,regression,#,0,inf,-,,,,,,https://www.rdkit.org/docs/source/rdkit.Chem.rdMolDescriptors.html#rdkit.Chem.rdMolDescriptors.CalcNumHBD +Physicochemical,Lipinski,Lipinski Rule of 5,,regression,# of 4,0,4,-,,,,,,https://en.wikipedia.org/wiki/Lipinski%27s_rule_of_five#Components_of_the_rule +Physicochemical,QED,Quantitative Estimate of Druglikeness (QED),,regression,-,0,1,-,,,,,,https://www.rdkit.org/docs/source/rdkit.Chem.QED.html#rdkit.Chem.QED.qed +Physicochemical,stereo_centers,Stereo Centers,,regression,#,0,inf,-,,,,,,https://www.rdkit.org/docs/source/rdkit.Chem.rdMolDescriptors.html#rdkit.Chem.rdMolDescriptors.CalcNumAtomStereoCenters +Physicochemical,tpsa,Topological Polar Surface Area (TPSA),,regression,Å^2,0,inf,-,,,,,,https://www.rdkit.org/docs/source/rdkit.Chem.rdMolDescriptors.html#rdkit.Chem.rdMolDescriptors.CalcTPSA +Absorption,HIA_Hou,Human Intestinal Absorption,578,classification,-,0,1,human,2,0.996606708,0.980679753,,,https://tdcommons.ai/single_pred_tasks/adme/#hia-human-intestinal-absorption-hou-et-al +Absorption,Bioavailability_Ma,Oral Bioavailability,640,classification,-,0,1,human,5,0.898285256,0.783118134,,,https://tdcommons.ai/single_pred_tasks/adme/#bioavailability-ma-et-al +Absorption,Solubility_AqSolDB,Aqueous Solubility,9982,regression,log(mol/L),-inf,inf,-,1,,,0.814276627,0.673885697,https://tdcommons.ai/single_pred_tasks/adme/#solubility-aqsoldb +Absorption,Lipophilicity_AstraZeneca,Lipophilicity,4200,regression,log-ratio,-inf,inf,-,1,,,0.746047462,0.430572678,https://tdcommons.ai/single_pred_tasks/adme/#lipophilicity-astrazeneca +Absorption,HydrationFreeEnergy_FreeSolv,Hydration Free Energy,642,regression,kcal/mol,-inf,inf,-,-,,,0.919245,0.71341,https://tdcommons.ai/single_pred_tasks/adme/#hydration-free-energy-freesolv +Absorption,Caco2_Wang,Cell Effective Permeability,906,regression,log(10^-6 cm/s),-inf,inf,human,5,,,0.744364201,0.300075312,https://tdcommons.ai/single_pred_tasks/adme/#caco-2-cell-effective-permeability-wang-et-al +Absorption,PAMPA_NCATS,PAMPA Permeability,2034,classification,-,0,1,artificial membrane,-,0.94826615,0.798405536,,,https://tdcommons.ai/single_pred_tasks/adme/#pampa-permeability-ncats +Absorption,Pgp_Broccatelli,P-glycoprotein Inhibition,1212,classification,-,0,1,human pgp / mouse cells,10,0.959242927,0.945843699,,,https://tdcommons.ai/single_pred_tasks/adme/#pgp-p-glycoprotein-inhibition-broccatelli-et-al +Distribution,BBB_Martins,Blood-Brain Barrier Penetration,1975,classification,-,0,1,human,11,0.978083609,0.93934044,,,https://tdcommons.ai/single_pred_tasks/adme/#bbb-blood-brain-barrier-martins-et-al +Distribution,PPBR_AZ,Plasma Protein Binding Rate,1614,regression,%,0,100,human,3,,,0.462089051,7.754102431,https://tdcommons.ai/single_pred_tasks/adme/#ppbr-plasma-protein-binding-rate-astrazeneca +Distribution,VDss_Lombardo,Volume of Distribution at Steady State,1111,regression,L/kg,0,inf,human,10,,,-0.610145027,5.890426238,https://tdcommons.ai/single_pred_tasks/adme/#vdss-volumn-of-distribution-at-steady-state-lombardo-et-al +Excretion,Half_Life_Obach,Half Life,665,regression,hr,0,inf,human,7,,,-1.551572848,31.04670644,https://tdcommons.ai/single_pred_tasks/adme/#half-life-obach-et-al +Excretion,Clearance_Hepatocyte_AZ,Drug Clearance (Hepatocyte),1020,regression,uL/min/10^6 cells,0,inf,human,4,,,0.302233775,31.562803,https://tdcommons.ai/single_pred_tasks/adme/#clearance-astrazeneca +Excretion,Clearance_Microsome_AZ,Drug Clearance (Microsome),1102,regression,uL/min/mg,0,inf,human,2,,,0.300325493,25.2952124,https://tdcommons.ai/single_pred_tasks/adme/#clearance-astrazeneca +Metabolism,CYP1A2_Veith,CYP1A2 Inhibition,12579,classification,-,0,1,human,-,0.934630479,0.941599044,,,https://tdcommons.ai/single_pred_tasks/adme/#cyp-p450-1a2-inhibition-veith-et-al +Metabolism,CYP2C19_Veith,CYP2C19 Inhibition,12665,classification,-,0,1,human,-,0.882382711,0.907060295,,,https://tdcommons.ai/single_pred_tasks/adme/#cyp-p450-2c19-inhibition-veith-et-al +Metabolism,CYP2C9_Veith,CYP2C9 Inhibition,12092,classification,-,0,1,human,4,0.809011378,0.905095011,,,https://tdcommons.ai/single_pred_tasks/adme/#cyp-p450-2c9-inhibition-veith-et-al +Metabolism,CYP2D6_Veith,CYP2D6 Inhibition,13130,classification,-,0,1,human,3,0.734222423,0.887889936,,,https://tdcommons.ai/single_pred_tasks/adme/#cyp-p450-2d6-inhibition-veith-et-al +Metabolism,CYP3A4_Veith,CYP3A4 Inhibition,12328,classification,-,0,1,human,3,0.881595257,0.914678766,,,https://tdcommons.ai/single_pred_tasks/adme/#cyp-p450-3a4-inhibition-veith-et-al +Metabolism,CYP2C9_Substrate_CarbonMangels,CYP2C9 Substrate,666,classification,-,0,1,human,4,0.3002083,0.695313349,,,https://tdcommons.ai/single_pred_tasks/adme/#cyp2c9-substrate-carbon-mangels-et-al +Metabolism,CYP2D6_Substrate_CarbonMangels,CYP2D6 Substrate,664,classification,-,0,1,human,3,0.573863564,0.768020178,,,https://tdcommons.ai/single_pred_tasks/adme/#cyp2d6-substrate-carbon-mangels-et-al +Metabolism,CYP3A4_Substrate_CarbonMangels,CYP3A4 Substrate,667,classification,-,0,1,human,7,0.701417532,0.714367012,,,https://tdcommons.ai/single_pred_tasks/adme/#cyp3a4-substrate-carbon-mangels-et-al +Toxicity,hERG,hERG Blocking,648,classification,-,0,1,human,4,0.925968621,0.858940863,,,https://tdcommons.ai/single_pred_tasks/tox/#herg-blockers +Toxicity,ClinTox,Clinical Toxicity,1459,classification,-,0,1,human,-,0.425390242,0.869768917,,,https://tdcommons.ai/single_pred_tasks/tox/#clintox +Toxicity,AMES,Mutagenicity,7255,classification,-,0,1,salmonella typhimurium,2,0.912265988,0.892359338,,,https://tdcommons.ai/single_pred_tasks/tox/#ames-mutagenicity +Toxicity,DILI,Drug Induced Liver Injury,475,classification,-,0,1,human,5,0.858379277,0.865054697,,,https://tdcommons.ai/single_pred_tasks/tox/#dili-drug-induced-liver-injury +Toxicity,Carcinogens_Lagunin,Carcinogenicity,278,classification,-,0,1,rodent,-,0.728486215,0.839515637,,,https://tdcommons.ai/single_pred_tasks/tox/#carcinogens +Toxicity,LD50_Zhu,Acute Toxicity LD50,7342,regression,log(1/(mol/kg)),-inf,inf,rat,5,,,0.612500001,0.436945841,https://tdcommons.ai/single_pred_tasks/tox/#acute-toxicity-ld50 +Toxicity,Skin_Reaction,Skin Reaction,404,classification,-,0,1,mouse,-,0.867316907,0.817321607,,,https://tdcommons.ai/single_pred_tasks/tox/#skin-reaction +Toxicity,NR-AR,Androgen Receptor (Full Length),6758,classification,-,0,1,human,-,0.620952705,0.821381643,,,https://tdcommons.ai/single_pred_tasks/tox/#tox21 +Toxicity,NR-AR-LBD,Androgen Receptor (Ligand Binding Domain),7265,classification,-,0,1,human,-,0.711622503,0.899019067,,,https://tdcommons.ai/single_pred_tasks/tox/#tox21 +Toxicity,NR-AhR,Aryl Hydrocarbon Receptor,6549,classification,-,0,1,human,-,0.62899255,0.887560753,,,https://tdcommons.ai/single_pred_tasks/tox/#tox21 +Toxicity,NR-Aromatase,Aromatase,5821,classification,-,0,1,human,-,0.453731846,0.874020253,,,https://tdcommons.ai/single_pred_tasks/tox/#tox21 +Toxicity,NR-ER,Estrogen Receptor (Full Length),6955,classification,-,0,1,human,-,0.451886067,0.715059484,,,https://tdcommons.ai/single_pred_tasks/tox/#tox21 +Toxicity,NR-ER-LBD,Estrogen Receptor (Ligand Binding Domain),6193,classification,-,0,1,human,-,0.469083765,0.814587495,,,https://tdcommons.ai/single_pred_tasks/tox/#tox21 +Toxicity,NR-PPAR-gamma,Peroxisome Proliferator-Activated Receptor Gamma,6450,classification,-,0,1,human,-,0.373228274,0.884272416,,,https://tdcommons.ai/single_pred_tasks/tox/#tox21 +Toxicity,SR-ARE,Nuclear Factor (Erythroid-Derived 2)-Like 2/Antioxidant Responsive Element,5832,classification,-,0,1,human,-,0.548436893,0.837783074,,,https://tdcommons.ai/single_pred_tasks/tox/#tox21 +Toxicity,SR-ATAD5,ATPase Family AAA Domain-Containing Protein 5 (ATAD5),7072,classification,-,0,1,human,-,0.324797882,0.879084144,,,https://tdcommons.ai/single_pred_tasks/tox/#tox21 +Toxicity,SR-HSE,Heat Shock Factor Response Element,6467,classification,-,0,1,human,-,0.380343661,0.852138257,,,https://tdcommons.ai/single_pred_tasks/tox/#tox21 +Toxicity,SR-MMP,Mitochondrial Membrane Potential,5810,classification,-,0,1,human,-,0.744683945,0.925379251,,,https://tdcommons.ai/single_pred_tasks/tox/#tox21 +Toxicity,SR-p53,Tumor Protein p53,6774,classification,-,0,1,human,-,0.408814321,0.878568992,,,https://tdcommons.ai/single_pred_tasks/tox/#tox21 \ No newline at end of file diff --git a/admet_ai/web/app/templates/index.html b/admet_ai/web/app/templates/index.html index ded50d1..68f8309 100644 --- a/admet_ai/web/app/templates/index.html +++ b/admet_ai/web/app/templates/index.html @@ -139,7 +139,9 @@
Download Predictions: Predictions for the first {{
@@ -440,7 +442,8 @@ {{ category }}
{% set pred = smiles_to_property_id_to_pred[smiles][row["id"]] %}
- {{ ("{:.2f}" if pred > 0.005 or pred < -0.005 else "{:.2e}").format(pred) }}
+ {% set pred = min(max(pred, row["minimum"]), row["maximum"]) %}
+ {{ ("{:.2f}" if pred == 0 or pred > 0.005 or pred < -0.005 else "{:.2e}").format(pred) }}
diff --git a/admet_ai/web/app/views.py b/admet_ai/web/app/views.py
index 72db1ff..b8ea799 100644
--- a/admet_ai/web/app/views.py
+++ b/admet_ai/web/app/views.py
@@ -57,6 +57,8 @@ def render(**kwargs) -> str:
atc_code=session.get("atc_code") or "all",
heartbeat_frequency=app.config["HEARTBEAT_FREQUENCY"],
string_to_html_sup=string_to_html_sup,
+ min=min,
+ max=max,
text_smiles=session.get("text_smiles", ""),
version=__version__,
**kwargs,