Filtering nucleosomal fragments

[leandro-ventimiglia]

Hello,

I started using Signac to analyse my multiome dataset.
My goal is to find enhancers-promoters interactions. I would like to know if it is a good practice to filter out all the nucleosome fragments (just keeping all the fragments with a length shorter than 140) after the initial clusterization step and before running cicero to find co-accesible peaks.
Thanks

[timoast]

This is not something that is typically being done for scATAC-seq analysis