diff --git a/jwst/regtest/conftest.py b/jwst/regtest/conftest.py
index 5eb902d6c3..10a85af7fd 100644
--- a/jwst/regtest/conftest.py
+++ b/jwst/regtest/conftest.py
@@ -250,6 +250,7 @@ def fitsdiff_default_kwargs():
         ignore_hdus=['ASDF'],
         ignore_keywords=ignore_keywords,
         ignore_fields=ignore_keywords,
+        ignore_comments=["*"],
         rtol=1e-5,
         atol=1e-7,
     )