diff --git a/catkit2/services/hamamatsu_camera/hamamatsu_camera.py b/catkit2/services/hamamatsu_camera/hamamatsu_camera.py
index a817ce004..92d620101 100644
--- a/catkit2/services/hamamatsu_camera/hamamatsu_camera.py
+++ b/catkit2/services/hamamatsu_camera/hamamatsu_camera.py
@@ -207,6 +207,12 @@ def acquisition_loop(self):
                     self.log.warning('Timeout while waiting for frame')
                 if self.cam.wait_capevent_frameready(timeout_millisec) is False:
                     raise RuntimeError(f'Dcam.wait_capevent_frameready({timeout_millisec}) fails with error {self.cam.lasterr()}')
+
+                if self.cam.buf_getframedata(-2) is False:
+                    # If there is no second to last frame, it means we just acquired the first frame.
+                    # In this case, drop the current frame since it always contains systematic errors.
+                    break
+
                 img = self.cam.buf_getlastframedata()
                 self.images.submit_data(img.astype('float32'))