diff --git a/CHANGELOG.md b/CHANGELOG.md
index b9f997b842c..41f9575e5cb 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -91,6 +91,7 @@
 
 - Stopped ignoring nanoseconds in `pd.Timedelta` scalars.
 - Fixed AssertionError in tree of binary operations.
+- Fixed `inplace` argument for Series objects derived from DataFrame columns.
 
 #### Behavior Change
 
diff --git a/src/snowflake/snowpark/modin/pandas/series.py b/src/snowflake/snowpark/modin/pandas/series.py
index 6e1b93437a8..7fb73ebbd37 100644
--- a/src/snowflake/snowpark/modin/pandas/series.py
+++ b/src/snowflake/snowpark/modin/pandas/series.py
@@ -2752,8 +2752,6 @@ def _update_inplace(self, new_query_compiler):
         # Propagate changes back to parent so that column in dataframe had the same contents
         if self._parent is not None:
             if self._parent_axis == 0:
-                self._parent.loc[self.name] = self
-            else:
                 self._parent[self.name] = self
 
     def _create_or_update_from_compiler(self, new_query_compiler, inplace=False):
diff --git a/tests/integ/modin/series/test_fillna.py b/tests/integ/modin/series/test_fillna.py
index 567f45db084..9371cd0dcd1 100644
--- a/tests/integ/modin/series/test_fillna.py
+++ b/tests/integ/modin/series/test_fillna.py
@@ -188,3 +188,16 @@ def test_argument_negative(test_fillna_series, test_fillna_df):
         expect_exception_type=TypeError,
         assert_exception_equal=False,
     )
+
+
+@sql_count_checker(query_count=1)
+def test_inplace_fillna_from_df():
+    def inplace_fillna(df):
+        df["B"].fillna(method="ffill", inplace=True)
+        return df
+
+    eval_snowpark_pandas_result(
+        pd.DataFrame([[1, 2, 3], [4, None, 6]], columns=list("ABC")),
+        native_pd.DataFrame([[1, 2, 3], [4, None, 6]], columns=list("ABC")),
+        inplace_fillna,
+    )