diff --git a/scrapy_poet/injection.py b/scrapy_poet/injection.py
index 7bac5b68..2e8189f0 100644
--- a/scrapy_poet/injection.py
+++ b/scrapy_poet/injection.py
@@ -20,7 +20,7 @@
 from weakref import WeakKeyDictionary
 
 import andi
-from andi.typeutils import issubclass_safe
+from andi.typeutils import issubclass_safe, strip_annotated
 from scrapy import Request, Spider
 from scrapy.crawler import Crawler
 from scrapy.http import Response
@@ -224,7 +224,7 @@ def _get_dynamic_deps_factory_text(
         # https://github.com/python/cpython/blob/v3.11.9/Lib/dataclasses.py#L413
         args = [f"{name}_arg: {name}" for name in type_names]
         args_str = ", ".join(args)
-        result_args = [f"{name}: {name}_arg" for name in type_names]
+        result_args = [f"strip_annotated({name}): {name}_arg" for name in type_names]
         result_args_str = ", ".join(result_args)
         create_args_str = ", ".join(type_names)
         return (
@@ -245,12 +245,14 @@ def _get_dynamic_deps_factory(
         corresponding args. It has correct type hints so that it can be used as
         an ``andi`` custom builder.
         """
-        ns: Dict[str, type] = {}
+        type_names: List[str] = []
         for type_ in dynamic_types:
+            type_ = cast(type, strip_annotated(type_))
             if not isinstance(type_, type):
                 raise TypeError(f"Expected a dynamic dependency type, got {type_!r}")
-            ns[type_.__name__] = type_
-        txt = Injector._get_dynamic_deps_factory_text(ns.keys())
+            type_names.append(type_.__name__)
+        txt = Injector._get_dynamic_deps_factory_text(type_names)
+        ns: Dict[str, Any] = {}
         exec(txt, globals(), ns)
         return ns["__create_fn__"](*dynamic_types)
 
diff --git a/tests/test_injection.py b/tests/test_injection.py
index 90f03104..a2a216e5 100644
--- a/tests/test_injection.py
+++ b/tests/test_injection.py
@@ -666,6 +666,35 @@ def callback(dd: DynamicDeps):
         instances = yield from injector.build_instances(request, response, plan)
         assert set(instances) == {TestItemPage, TestItem, DynamicDeps}
 
+    @pytest.mark.skipif(
+        sys.version_info < (3, 9), reason="No Annotated support in Python < 3.9"
+    )
+    @inlineCallbacks
+    def test_dynamic_deps_annotated(self):
+        from typing import Annotated
+
+        def callback(dd: DynamicDeps):
+            pass
+
+        provider = get_provider({Cls1, Cls2})
+        injector = get_injector_for_testing({provider: 1})
+
+        expected_instances = {
+            DynamicDeps: DynamicDeps({Cls1: Cls1(), Cls2: Cls2()}),
+            Annotated[Cls1, 42]: Cls1(),
+            Annotated[Cls2, "foo"]: Cls2(),
+        }
+        expected_kwargs = {
+            "dd": DynamicDeps({Cls1: Cls1(), Cls2: Cls2()}),
+        }
+        yield self._assert_instances(
+            injector,
+            callback,
+            expected_instances,
+            expected_kwargs,
+            reqmeta={"inject": [Annotated[Cls1, 42], Annotated[Cls2, "foo"]]},
+        )
+
 
 class Html(Injectable):
     url = "http://example.com"
@@ -972,7 +1001,7 @@ def test_dynamic_deps_factory_text():
         txt
         == """def __create_fn__(int, Cls1):
  def dynamic_deps_factory(int_arg: int, Cls1_arg: Cls1) -> DynamicDeps:
-  return DynamicDeps({int: int_arg, Cls1: Cls1_arg})
+  return DynamicDeps({strip_annotated(int): int_arg, strip_annotated(Cls1): Cls1_arg})
  return dynamic_deps_factory"""
     )
 
@@ -989,6 +1018,26 @@ def test_dynamic_deps_factory():
     assert dd == {int: 42, Cls1: c}
 
 
+@pytest.mark.skipif(
+    sys.version_info < (3, 9), reason="No Annotated support in Python < 3.9"
+)
+def test_dynamic_deps_factory_annotated():
+    from typing import Annotated
+
+    fn = Injector._get_dynamic_deps_factory(
+        [Annotated[Cls1, 42], Annotated[Cls2, "foo"]]
+    )
+    args = andi.inspect(fn)
+    assert args == {
+        "Cls1_arg": [Annotated[Cls1, 42]],
+        "Cls2_arg": [Annotated[Cls2, "foo"]],
+    }
+    c1 = Cls1()
+    c2 = Cls2()
+    dd = fn(Cls1_arg=c1, Cls2_arg=c2)
+    assert dd == {Cls1: c1, Cls2: c2}
+
+
 def test_dynamic_deps_factory_bad_input():
     with pytest.raises(
         TypeError,