diff --git a/test/CMakeLists.txt b/test/CMakeLists.txt
index f41f664ce6..9ec53dc567 100644
--- a/test/CMakeLists.txt
+++ b/test/CMakeLists.txt
@@ -43,23 +43,26 @@ endif()
 proj_add_gie_test("Builtins" "gie/builtins.gie")
 proj_add_gie_test("Builtins2" "gie/more_builtins.gie")
 proj_add_gie_test("Axisswap" "gie/axisswap.gie")
-proj_add_gie_test("Deformation" "gie/deformation.gie")
 proj_add_gie_test("Ellipsoid" "gie/ellipsoid.gie")
 proj_add_gie_test("GDA" "gie/GDA.gie")
 proj_add_gie_test("4D-API-cs2cs-style" "gie/4D-API_cs2cs-style.gie")
 proj_add_gie_test("DHDN_ETRS89" "gie/DHDN_ETRS89.gie")
 proj_add_gie_test("Unitconvert" "gie/unitconvert.gie")
-proj_add_gie_test("geotiff_grids" "gie/geotiff_grids.gie")
 proj_add_gie_test("adams_hemi" "gie/adams_hemi.gie")
 proj_add_gie_test("adams_ws1" "gie/adams_ws1.gie")
 proj_add_gie_test("adams_ws2" "gie/adams_ws2.gie")
 proj_add_gie_test("guyou" "gie/guyou.gie")
 proj_add_gie_test("peirce_q" "gie/peirce_q.gie")
-proj_add_gie_test("defmodel" "gie/defmodel.gie")
 proj_add_gie_test("tinshift" "gie/tinshift.gie")
+
+if(TIFF_ENABLED)
+proj_add_gie_test("Deformation" "gie/deformation.gie")
+proj_add_gie_test("geotiff_grids" "gie/geotiff_grids.gie")
+proj_add_gie_test("defmodel" "gie/defmodel.gie")
 proj_add_gie_test("gridshift" "gie/gridshift.gie")
+endif()
 
-if(CURL_ENABLED AND RUN_NETWORK_DEPENDENT_TESTS)
+if(TIFF_ENABLED AND CURL_ENABLED AND RUN_NETWORK_DEPENDENT_TESTS)
 proj_add_gie_network_dependent_test("nkg" "gie/nkg.gie")
 endif()
 
diff --git a/test/unit/CMakeLists.txt b/test/unit/CMakeLists.txt
index 1ec1dcb892..e58b11931a 100644
--- a/test/unit/CMakeLists.txt
+++ b/test/unit/CMakeLists.txt
@@ -154,6 +154,9 @@ target_link_libraries(proj_test_cpp_api
 add_test(NAME proj_test_cpp_api COMMAND proj_test_cpp_api)
 set_property(TEST proj_test_cpp_api
   PROPERTY ENVIRONMENT ${PROJ_TEST_ENVIRONMENT})
+if(TIFF_ENABLED)
+  target_compile_definitions(proj_test_cpp_api PRIVATE -DTIFF_ENABLED)
+endif()
 
 add_executable(gie_self_tests
   main.cpp
@@ -161,9 +164,13 @@ add_executable(gie_self_tests
 target_link_libraries(gie_self_tests
   PRIVATE GTest::gtest
   PRIVATE ${PROJ_LIBRARIES})
+  
 add_test(NAME gie_self_tests COMMAND gie_self_tests)
 set_property(TEST gie_self_tests
   PROPERTY ENVIRONMENT ${PROJ_TEST_ENVIRONMENT})
+if(TIFF_ENABLED)
+  target_compile_definitions(gie_self_tests PRIVATE -DTIFF_ENABLED)
+endif()
 
 add_executable(test_network
   main.cpp
@@ -183,9 +190,11 @@ target_link_libraries(test_network
   PRIVATE GTest::gtest
   PRIVATE ${PROJ_LIBRARIES}
   PRIVATE ${SQLITE3_LIBRARY})
+if(TIFF_ENABLED)
 add_test(NAME test_network COMMAND test_network)
 set_property(TEST test_network
   PROPERTY ENVIRONMENT ${PROJ_TEST_ENVIRONMENT})
+endif()
 
 add_executable(test_defmodel
   main.cpp
diff --git a/test/unit/gie_self_tests.cpp b/test/unit/gie_self_tests.cpp
index b8ab1da233..646e1cb718 100644
--- a/test/unit/gie_self_tests.cpp
+++ b/test/unit/gie_self_tests.cpp
@@ -407,6 +407,7 @@ TEST(gie, info_functions) {
 
     proj_destroy(P);
 
+#ifdef TIFF_ENABLED
     /* proj_grid_info() */
     grid_info = proj_grid_info("tests/test_hgrid.tif");
     ASSERT_NE(std::string(grid_info.filename), "");
@@ -420,6 +421,7 @@ TEST(gie, info_functions) {
     EXPECT_NEAR(grid_info.lowerleft.phi, 0.90757121103705141, 1e-15);
     EXPECT_NEAR(grid_info.upperright.lam, 0.12217304763960307, 1e-15);
     EXPECT_NEAR(grid_info.upperright.phi, 0.95993108859688125, 1e-15);
+#endif
 
     grid_info = proj_grid_info("nonexistinggrid");
     ASSERT_EQ(std::string(grid_info.filename), "");
diff --git a/test/unit/test_c_api.cpp b/test/unit/test_c_api.cpp
index 6862f03b2d..18fbd1feab 100644
--- a/test/unit/test_c_api.cpp
+++ b/test/unit/test_c_api.cpp
@@ -1661,6 +1661,7 @@ TEST_F(CApi, proj_coordoperation_get_grid_used) {
 
 // ---------------------------------------------------------------------------
 
+#ifdef TIFF_ENABLED
 TEST_F(CApi, proj_coordoperation_get_grid_used_fullname_caching) {
     // Test bugfix for
     // https://github.com/OSGeo/PROJ/issues/3444#issuecomment-1309499342
@@ -1688,6 +1689,7 @@ TEST_F(CApi, proj_coordoperation_get_grid_used_fullname_caching) {
             << std::string(fullName);
     }
 }
+#endif
 
 // ---------------------------------------------------------------------------
 
diff --git a/test/unit/test_grids.cpp b/test/unit/test_grids.cpp
index 29dd080c24..3eab20feff 100644
--- a/test/unit/test_grids.cpp
+++ b/test/unit/test_grids.cpp
@@ -117,6 +117,31 @@ TEST_F(GridTest, HorizontalShiftGridSet_null) {
 
 // ---------------------------------------------------------------------------
 
+TEST_F(GridTest, GenericShiftGridSet_null) {
+    auto gridSet = NS_PROJ::GenericShiftGridSet::open(m_ctxt, "null");
+    ASSERT_NE(gridSet, nullptr);
+    auto grid = gridSet->gridAt(0.0, 0.0);
+    ASSERT_NE(grid, nullptr);
+    EXPECT_EQ(grid->width(), 3);
+    EXPECT_EQ(grid->height(), 3);
+    EXPECT_EQ(grid->extentAndRes().west, -M_PI);
+    EXPECT_TRUE(grid->isNullGrid());
+    EXPECT_FALSE(grid->hasChanged());
+    float out = -1.0f;
+    EXPECT_TRUE(grid->valueAt(0, 0, 0, out));
+    EXPECT_EQ(out, 0.0f);
+    EXPECT_EQ(grid->unit(0), "");
+    EXPECT_EQ(grid->description(0), "");
+    EXPECT_EQ(grid->metadataItem("foo"), "");
+    EXPECT_EQ(grid->samplesPerPixel(), 0);
+    gridSet->reassign_context(m_ctxt2);
+    gridSet->reopen(m_ctxt2);
+}
+
+#ifdef TIFF_ENABLED
+
+// ---------------------------------------------------------------------------
+
 TEST_F(GridTest, HorizontalShiftGridSet_gtiff) {
     auto gridSet =
         NS_PROJ::HorizontalShiftGridSet::open(m_ctxt, "tests/test_hgrid.tif");
@@ -147,29 +172,6 @@ TEST_F(GridTest, HorizontalShiftGridSet_gtiff) {
 
 // ---------------------------------------------------------------------------
 
-TEST_F(GridTest, GenericShiftGridSet_null) {
-    auto gridSet = NS_PROJ::GenericShiftGridSet::open(m_ctxt, "null");
-    ASSERT_NE(gridSet, nullptr);
-    auto grid = gridSet->gridAt(0.0, 0.0);
-    ASSERT_NE(grid, nullptr);
-    EXPECT_EQ(grid->width(), 3);
-    EXPECT_EQ(grid->height(), 3);
-    EXPECT_EQ(grid->extentAndRes().west, -M_PI);
-    EXPECT_TRUE(grid->isNullGrid());
-    EXPECT_FALSE(grid->hasChanged());
-    float out = -1.0f;
-    EXPECT_TRUE(grid->valueAt(0, 0, 0, out));
-    EXPECT_EQ(out, 0.0f);
-    EXPECT_EQ(grid->unit(0), "");
-    EXPECT_EQ(grid->description(0), "");
-    EXPECT_EQ(grid->metadataItem("foo"), "");
-    EXPECT_EQ(grid->samplesPerPixel(), 0);
-    gridSet->reassign_context(m_ctxt2);
-    gridSet->reopen(m_ctxt2);
-}
-
-// ---------------------------------------------------------------------------
-
 TEST_F(GridTest, GenericShiftGridSet_gtiff) {
     ASSERT_EQ(NS_PROJ::GenericShiftGridSet::open(m_ctxt, "foobar"), nullptr);
     auto gridSet = NS_PROJ::GenericShiftGridSet::open(
@@ -335,4 +337,6 @@ TEST_F(GridTest, GenericShiftGridSet_gtiff_projected) {
     EXPECT_EQ(grid->extentAndRes().resY, 1000);
 }
 
+#endif // TIFF_ENABLED
+
 } // namespace