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Historically, one would have wanted to sequence fewer individuals at higher depth to get confident genotype calls, rather than sequence more individuals at lower depth. Recent advances in bioinformatics have enabled low-coverage whole genome sequencing -a.k.a. lcWGS to be a viable options for studies of outbred non-model systems. More +a.k.a. lcWGS to be a viable option for studies of outbred non-model systems. More and more studies are emerging that have adopted lcWGS, which is pretty cool. However, calling structural variants at low depth is challenging, especially with short reads.

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