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wrong germline species assigned #95

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Darthvadar opened this issue Sep 21, 2024 · 0 comments
Open

wrong germline species assigned #95

Darthvadar opened this issue Sep 21, 2024 · 0 comments

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@Darthvadar
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I use durvalumab sequences as example, which is well known fully human antibody.

when I tested it on webapp (https://opig.stats.ox.ac.uk/webapps/sabdab-sabpred/sabpred/anarci/), it clearly told this is human H domain.

image

but when I tested it with anarci python delivered in Conda, it said this is alpaca H domain.
image

I manually searched this sequence against HMM profiles in Anarci python package by HMMScan program, the model of alpaca was ranked first over human model.

there should be something wrong ...

image

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