diff --git a/tests/test_cli.py b/tests/test_cli.py
index 3a00145889..7f7e68f7ed 100644
--- a/tests/test_cli.py
+++ b/tests/test_cli.py
@@ -17,6 +17,7 @@
     DEFAULT_SKIP_MAGIC,
     ExtractionConfig,
 )
+from unblob.testing import is_sandbox_available
 from unblob.ui import (
     NullProgressReporter,
     ProgressReporter,
@@ -425,3 +426,29 @@ def test_clear_skip_magics(
     assert sorted(process_file_mock.call_args.args[0].skip_magic) == sorted(
         skip_magic
     ), fail_message
+
+
+@pytest.mark.skipif(
+    not is_sandbox_available(), reason="Sandboxing is only available on Linux"
+)
+def test_sandbox_escape(tmp_path: Path):
+    runner = CliRunner()
+
+    in_path = tmp_path / "input"
+    in_path.touch()
+    extract_dir = tmp_path / "extract-dir"
+    params = ["--extract-dir", str(extract_dir), str(in_path)]
+
+    unrelated_file = tmp_path / "unrelated"
+
+    process_file_mock = mock.MagicMock(
+        side_effect=lambda *_args, **_kwargs: unrelated_file.write_text(
+            "sandbox escape"
+        )
+    )
+    with mock.patch.object(unblob.cli, "process_file", process_file_mock):
+        result = runner.invoke(unblob.cli.cli, params)
+
+    assert result.exit_code != 0
+    assert isinstance(result.exception, PermissionError)
+    process_file_mock.assert_called_once()
diff --git a/tests/test_sandbox.py b/tests/test_sandbox.py
new file mode 100644
index 0000000000..ee0feff16a
--- /dev/null
+++ b/tests/test_sandbox.py
@@ -0,0 +1,57 @@
+from pathlib import Path
+
+import pytest
+
+from unblob.processing import ExtractionConfig
+from unblob.sandbox import Sandbox
+from unblob.testing import is_sandbox_available
+
+pytestmark = pytest.mark.skipif(
+    not is_sandbox_available(), reason="Sandboxing only works on Linux"
+)
+
+
+@pytest.fixture
+def log_path(tmp_path):
+    return tmp_path / "unblob.log"
+
+
+@pytest.fixture
+def extraction_config(extraction_config, tmp_path):
+    extraction_config.extract_root = tmp_path / "extract" / "root"
+    # parent has to exist
+    extraction_config.extract_root.parent.mkdir()
+    return extraction_config
+
+
+@pytest.fixture
+def sandbox(extraction_config: ExtractionConfig, log_path: Path):
+    return Sandbox(extraction_config, log_path, None)
+
+
+def test_necessary_resources_can_be_created_in_sandbox(
+    sandbox: Sandbox, extraction_config: ExtractionConfig, log_path: Path
+):
+    directory_in_extract_root = extraction_config.extract_root / "path" / "to" / "dir"
+    file_in_extract_root = directory_in_extract_root / "file"
+
+    sandbox.run(extraction_config.extract_root.mkdir, parents=True)
+    sandbox.run(directory_in_extract_root.mkdir, parents=True)
+
+    sandbox.run(file_in_extract_root.touch)
+    sandbox.run(file_in_extract_root.write_text, "file content")
+
+    # log-file is already opened
+    log_path.touch()
+    sandbox.run(log_path.write_text, "log line")
+
+
+def test_access_outside_sandbox_is_not_possible(sandbox: Sandbox, tmp_path: Path):
+    unrelated_dir = tmp_path / "unrelated" / "path"
+    unrelated_file = tmp_path / "unrelated-file"
+
+    with pytest.raises(PermissionError):
+        sandbox.run(unrelated_dir.mkdir, parents=True)
+
+    with pytest.raises(PermissionError):
+        sandbox.run(unrelated_file.touch)
diff --git a/unblob/cli.py b/unblob/cli.py
index cb275e809c..498644e078 100755
--- a/unblob/cli.py
+++ b/unblob/cli.py
@@ -33,6 +33,7 @@
     ExtractionConfig,
     process_file,
 )
+from .sandbox import Sandbox
 from .ui import NullProgressReporter, RichConsoleProgressReporter
 
 logger = get_logger()
@@ -301,7 +302,8 @@ def cli(
     )
 
     logger.info("Start processing file", file=file)
-    process_results = process_file(config, file, report_file)
+    sandbox = Sandbox(config, log_path, report_file)
+    process_results = sandbox.run(process_file, config, file, report_file)
     if verbose == 0:
         if skip_extraction:
             print_scan_report(process_results)
diff --git a/unblob/pool.py b/unblob/pool.py
index eeee58ca7a..4b06ea3e85 100644
--- a/unblob/pool.py
+++ b/unblob/pool.py
@@ -203,10 +203,9 @@ def make_pool(process_num, handler, result_callback) -> Union[SinglePool, MultiP
 
 
 def _on_terminate(signum, frame):
-    with contextlib.suppress(StopIteration):
-        while True:
-            pool = next(iter(pools))
-            pool.close(immediate=True)
+    pools_snapshot = list(pools)
+    for pool in pools_snapshot:
+        pool.close(immediate=True)
 
     if callable(orig_signal_handlers[signum]):
         orig_signal_handlers[signum](signum, frame)
diff --git a/unblob/processing.py b/unblob/processing.py
index 1f9c74432b..ac93c20a1c 100644
--- a/unblob/processing.py
+++ b/unblob/processing.py
@@ -110,7 +110,6 @@ def get_extract_dir_for(self, path: Path) -> Path:
         return extract_dir.expanduser().resolve()
 
 
-@terminate_gracefully
 def process_file(
     config: ExtractionConfig, input_path: Path, report_file: Optional[Path] = None
 ) -> ProcessResult:
diff --git a/unblob/sandbox.py b/unblob/sandbox.py
new file mode 100644
index 0000000000..3608b5bf7f
--- /dev/null
+++ b/unblob/sandbox.py
@@ -0,0 +1,118 @@
+import ctypes
+import sys
+import threading
+from pathlib import Path
+from typing import Callable, Iterable, Optional, Type, TypeVar
+
+from structlog import get_logger
+from unblob_native.sandbox import (
+    AccessFS,
+    SandboxError,
+    restrict_access,
+)
+
+if sys.version_info >= (3, 10):
+    from typing import ParamSpec
+else:
+    from typing_extensions import ParamSpec
+
+from unblob.processing import ExtractionConfig
+
+logger = get_logger()
+
+P = ParamSpec("P")
+R = TypeVar("R")
+
+
+class Sandbox:
+    """Configures restricted file-systems to run functions in.
+
+    When calling ``run()``, a separate thread will be configured with
+    minimum required file-system permissions. All subprocesses spawned
+    from that thread will honor the restrictions.
+    """
+
+    def __init__(
+        self,
+        config: ExtractionConfig,
+        log_path: Path,
+        report_file: Optional[Path],
+        extra_restrictions: Iterable[AccessFS] = (),
+    ):
+        self.restrictions = [
+            # Python, shared libraries, extractor binaries and so on
+            AccessFS.read("/"),
+            # Multiprocessing
+            AccessFS.read_write("/dev/shm"),  # noqa: S108
+            # Extracted contents
+            AccessFS.read_write(config.extract_root),
+            AccessFS.make_dir(config.extract_root.parent),
+            AccessFS.read_write(log_path),
+            *extra_restrictions,
+        ]
+
+        if report_file:
+            self.restrictions += [
+                AccessFS.read_write(report_file),
+                AccessFS.make_reg(report_file.parent),
+            ]
+
+    def run(self, callback: Callable[P, R], *args: P.args, **kwargs: P.kwargs) -> R:
+        """Run callback with restricted filesystem access."""
+        exception = None
+        result = None
+
+        def _run_in_thread(callback, *args, **kwargs):
+            nonlocal exception, result
+
+            self._try_enter_sandbox()
+            try:
+                result = callback(*args, **kwargs)
+            except BaseException as e:
+                exception = e
+
+        thread = threading.Thread(
+            target=_run_in_thread, args=(callback, *args), kwargs=kwargs
+        )
+        thread.start()
+
+        try:
+            thread.join()
+        except KeyboardInterrupt:
+            raise_in_thread(thread, KeyboardInterrupt)
+            thread.join()
+
+        if exception:
+            raise exception  # pyright: ignore[reportGeneralTypeIssues]
+        return result  # pyright: ignore[reportReturnType]
+
+    def _try_enter_sandbox(self):
+        try:
+            restrict_access(*self.restrictions)
+        except SandboxError:
+            logger.warning(
+                "Sandboxing FS access is unavailable on this system, skipping."
+            )
+
+
+def raise_in_thread(thread: threading.Thread, exctype: Type) -> None:
+    if thread.ident is None:
+        raise RuntimeError("Thread is not started")
+
+    res = ctypes.pythonapi.PyThreadState_SetAsyncExc(
+        ctypes.c_ulong(thread.ident), ctypes.py_object(exctype)
+    )
+
+    # success
+    if res == 1:
+        return
+
+    # Need to revert the call to restore interpreter state
+    ctypes.pythonapi.PyThreadState_SetAsyncExc(ctypes.c_ulong(thread.ident), None)
+
+    # Thread could have exited since
+    if res == 0:
+        return
+
+    # Something bad have happened
+    raise RuntimeError("Could not raise exception in thread", thread.ident)
diff --git a/unblob/testing.py b/unblob/testing.py
index 75a786df34..b56c0f175a 100644
--- a/unblob/testing.py
+++ b/unblob/testing.py
@@ -1,6 +1,7 @@
 import binascii
 import glob
 import io
+import platform
 import shlex
 import subprocess
 from pathlib import Path
@@ -10,6 +11,7 @@
 from lark.lark import Lark
 from lark.visitors import Discard, Transformer
 from pytest_cov.embed import cleanup_on_sigterm
+from unblob_native.sandbox import AccessFS, SandboxError, restrict_access
 
 from unblob.finder import build_hyperscan_database
 from unblob.logging import configure_logger
@@ -217,3 +219,17 @@ def start(self, s):
             rv.write(line.data)
 
         return rv.getvalue()
+
+
+def is_sandbox_available():
+    is_sandbox_available = True
+
+    try:
+        restrict_access(AccessFS.read_write("/"))
+    except SandboxError:
+        is_sandbox_available = False
+
+    if platform.architecture == "x86_64" and platform.system == "linux":
+        assert is_sandbox_available, "Sandboxing should work at least on Linux-x86_64"
+
+    return is_sandbox_available