diff --git a/change/@ni-nimble-components-b8f24320-d835-42a0-b1d8-1b183206df94.json b/change/@ni-nimble-components-b8f24320-d835-42a0-b1d8-1b183206df94.json
new file mode 100644
index 0000000000..8c2d592396
--- /dev/null
+++ b/change/@ni-nimble-components-b8f24320-d835-42a0-b1d8-1b183206df94.json
@@ -0,0 +1,7 @@
+{
+  "type": "none",
+  "comment": "Disable failing tests in Firefox",
+  "packageName": "@ni/nimble-components",
+  "email": "20542556+mollykreis@users.noreply.github.com",
+  "dependentChangeType": "none"
+}
diff --git a/packages/nimble-components/src/rich-text/models/tests/markdown-serializer.spec.ts b/packages/nimble-components/src/rich-text/models/tests/markdown-serializer.spec.ts
index bac3489a91..aa2680fa6d 100644
--- a/packages/nimble-components/src/rich-text/models/tests/markdown-serializer.spec.ts
+++ b/packages/nimble-components/src/rich-text/models/tests/markdown-serializer.spec.ts
@@ -337,7 +337,8 @@ Plain text 3`);
 <user:1> `);
         });
 
-        it('Mention node', async () => {
+        // Firefox skipped, see https://github.com/ni/nimble/issues/2488
+        it('Mention node #SkipFirefox', async () => {
             await appendUserMentionConfiguration(element, [
                 { key: 'user:1', displayName: 'username1' }
             ]);
@@ -347,7 +348,8 @@ Plain text 3`);
             expect(element.getMarkdown()).toEqual('<user:1> ');
         });
 
-        it('Multiple Mention node of same type', async () => {
+        // Firefox skipped, see https://github.com/ni/nimble/issues/2488
+        it('Multiple Mention node of same type #SkipFirefox', async () => {
             await appendUserMentionConfiguration(element, [
                 { key: 'user:1', displayName: 'username1' },
                 { key: 'user:2', displayName: 'username2' }
diff --git a/packages/nimble-components/src/table-column/duration-text/tests/table-column-duration-text.spec.ts b/packages/nimble-components/src/table-column/duration-text/tests/table-column-duration-text.spec.ts
index 540a6e9235..bac0d350e9 100644
--- a/packages/nimble-components/src/table-column/duration-text/tests/table-column-duration-text.spec.ts
+++ b/packages/nimble-components/src/table-column/duration-text/tests/table-column-duration-text.spec.ts
@@ -142,7 +142,8 @@ describe('TableColumnDurationText', () => {
         expect(tablePageObject.getCellTitle(0, 0)).toEqual('');
     });
 
-    it('removes title on mouseout of cell', async () => {
+    // Firefox skipped, see https://github.com/ni/nimble/issues/2490
+    it('removes title on mouseout of cell #SkipFirefox', async () => {
         table.style.width = '100px';
         await table.setData([{ field: 8607022000 }]);
         await waitForUpdatesAsync();
@@ -161,7 +162,8 @@ describe('TableColumnDurationText', () => {
         );
     });
 
-    it('updates displayed date when lang token changes', async () => {
+    // Firefox skipped, see https://github.com/ni/nimble/issues/2490
+    it('updates displayed date when lang token changes #SkipFirefox', async () => {
         await table.setData([{ field: 8607022000 }]);
         await waitForUpdatesAsync();
         expect(tablePageObject.getRenderedCellTextContent(0, 0)).toBe(
diff --git a/packages/nimble-components/src/table/tests/table.spec.ts b/packages/nimble-components/src/table/tests/table.spec.ts
index f70939ba18..82aadfc841 100644
--- a/packages/nimble-components/src/table/tests/table.spec.ts
+++ b/packages/nimble-components/src/table/tests/table.spec.ts
@@ -2620,7 +2620,8 @@ describe('Table', () => {
             await waitForUpdatesAsync();
         }
 
-        it('maintains scroll position if data does not change', async () => {
+        // Firefox skipped, see https://github.com/ni/nimble/issues/2491
+        it('maintains scroll position if data does not change #SkipFirefox', async () => {
             await setDataAndScrollToBottom(largeData200);
             const scrollTopBeforeDisconnect = element.viewport.scrollTop;
             const firstRenderedRowBeforeDisconnect = getFirstRenderedRowDataIndex(largeData200);
@@ -2634,7 +2635,8 @@ describe('Table', () => {
             );
         });
 
-        it('updates scroll position if data length is reduced while not attached', async () => {
+        // Firefox skipped, see https://github.com/ni/nimble/issues/2491
+        it('updates scroll position if data length is reduced while not attached #SkipFirefox', async () => {
             await setDataAndScrollToBottom(largeData400);
             const scrollTopBeforeDisconnect = element.viewport.scrollTop;
             const firstRenderedRowBeforeDisconnect = getFirstRenderedRowDataIndex(largeData400);
@@ -2689,7 +2691,8 @@ describe('Table', () => {
             );
         });
 
-        it('adjusts the number of rendered rows when the table height decreases while not attached', async () => {
+        // Firefox skipped, see https://github.com/ni/nimble/issues/2491
+        it('adjusts the number of rendered rows when the table height decreases while not attached #SkipFirefox', async () => {
             element.style.height = '500px';
             await element.setData(largeData200);
             await waitForUpdatesAsync();