diff --git a/gmso/tests/test_mcf.py b/gmso/tests/test_mcf.py
index a0a3d592e..c6bbc7b83 100644
--- a/gmso/tests/test_mcf.py
+++ b/gmso/tests/test_mcf.py
@@ -1,4 +1,5 @@
 import re
+import subprocess
 
 import mbuild as mb
 import numpy as np
@@ -48,10 +49,32 @@ def parse_mcf(filename):
         if len(line) > 1:
             if line[1] == "Fragment_Connectivity":
                 mcf_idx["Fragment_Connectivity"] = idx
+        if len(line) > 1:
+            if line[1] == "Intra_Scaling":
+                mcf_idx["Intra_Scaling"] = idx
 
     return mcf_data, mcf_idx
 
 
+def run_cassandra(cassandra, inp_file):
+    """Calls Cassandra. Taken from mosdef_cassandra v0.3.2"""
+    cassandra_cmd = "{cassandra} {inp_file}".format(
+        cassandra=cassandra, inp_file=inp_file
+    )
+    p = subprocess.Popen(
+        cassandra_cmd,
+        shell=True,
+        stdout=subprocess.PIPE,
+        stderr=subprocess.PIPE,
+        universal_newlines=True,
+    )
+    out, err = p.communicate()
+
+    if p.returncode != 0 or "error" in err.lower() or "error" in out.lower():
+        return 1, out, err
+    return 0, out, err
+
+
 def is_charge_neutral(mcf_data, mcf_idx):
     n_sites = int(mcf_data[mcf_idx["Atom_Info"] + 1][0])
     net_q = 0.0
@@ -369,9 +392,21 @@ def test_top_with_mixture(self):
 
     @pytest.mark.skipif(not has_cassandra, reason="cassandra is not installed")
     def test_in_cassandra(self, typed_ethane):
+        """
+        This test runs a single point energy calculation in Cassandra using an MCF
+        generated by gmso and compare the total energy
+        to the energy of a simulation run with a MCF file generated using mosdef_cassandra
+        (which involves using a parmed.Structure)
+        """
+        from mosdef_cassandra.utils.detect import detect_cassandra_binaries
+        from mosdef_cassandra.writers.writers import write_input
+
         from gmso.external.convert_parmed import to_parmed
 
-        write_mcf(typed_ethane, "top.mcf")
+        # First run the mosdef_cassandra simulation. Mosdef_cassandra generates an input file
+        # as well as an MCF. Later, we will use a mosdef_cassandra
+        # input file as a template and replace the MCF file with the GMSO MCF file
+
         box = mb.Box([3.0, 3.0, 3.0])
         species = to_parmed(typed_ethane)
         system = mc.System([box], [species], mols_to_add=[[5]])
@@ -381,11 +416,86 @@ def test_in_cassandra(self, typed_ethane):
             system=system,
             moveset=moveset,
             run_type="equilibration",
-            run_length=100,
+            run_length=0,
+            temperature=300.0 * u.K,
+            run_name="nvt_mbuild",
+            seeds=[12356, 64321],
+        )
+
+        py, fraglib_setup, cassandra = detect_cassandra_binaries()
+
+        # TODO: not sure why the cassandra MCF writer of mBuild
+        # outputs a different intramolecular exclusions relative
+        # to the GMSO writer. This is a temporary fix to make the
+        # test pass. We should investigate this further.
+        # Also, try to use the function top.set_lj_scale() and see how
+        # to update subtopologies.
+
+        write_mcf(typed_ethane, "gmso.mcf")
+        mcf_data, mcf_idx = parse_mcf("gmso.mcf")
+        mcf_data[mcf_idx["Intra_Scaling"] + 1][0:4] = [
+            "0.0",
+            "0.0",
+            "0.0",
+            "1.0",
+        ]
+        mcf_data[mcf_idx["Intra_Scaling"] + 2][0:4] = [
+            "0.0",
+            "0.0",
+            "0.0",
+            "1.0",
+        ]
+        with open("gmso.mcf", mode="w") as f:
+            for line in mcf_data:
+                f.write(" ".join(line) + "\n")
+
+        inp_file = write_input(
+            system=system,
+            moveset=moveset,
+            run_type="equilibration",
+            run_length=0,
             temperature=300.0 * u.K,
-            run_name="top",
+            run_name="nvt_gmso",
+            seeds=[12356, 64321],
         )
 
+        with open(inp_file, mode="r") as f:
+            lines = f.read()
+            lines = lines.replace("species1.mcf", "gmso.mcf")
+            # The fragment files section is empty unless
+            # restart option is used in mosdef_cassandra.
+            # See the mosdef_cassandra.writers.inp_functions.generate_input
+            lines = lines.replace(
+                "# Fragment_Files",
+                "# Fragment_Files\nspecies1/frag1/frag1.dat  1\nspecies1/frag2/frag2.dat  2\n",
+            )
+
+        with open(inp_file, mode="w") as f:
+            f.writelines(lines)
+
+        # Run the simulation with the GMSO MCF file
+        code, out, err = run_cassandra(cassandra, inp_file)
+
+        assert code == 0
+        assert "complete" in out
+
+        # Parse log files
+        with open("nvt_gmso.out.log", mode="r") as f:
+            lines = f.readlines()
+            for line in lines:
+                if "Total system energy" in line:
+                    energy = float(line.split()[-1])
+                    break
+
+        with open("nvt_mbuild.out.log", mode="r") as f:
+            lines = f.readlines()
+            for line in lines:
+                if "Total system energy" in line:
+                    energy_ref = float(line.split()[-1])
+                    break
+
+        assert np.isclose(energy, energy_ref, rtol=1e-3)
+
     @pytest.mark.skipif(not has_parmed, reason="ParmEd is not installed")
     def test_parmed_vs_gmso(self, parmed_ethane):
         """