diff --git a/src/ontology/config/omim_exclusions.tsv b/src/ontology/config/omim_exclusions.tsv
index 3762d2c4..6216ccee 100644
--- a/src/ontology/config/omim_exclusions.tsv
+++ b/src/ontology/config/omim_exclusions.tsv
@@ -17306,3 +17306,4 @@ OMIM:620678	RINL	MONDO:excludeGene	FALSE
 OMIM:620682	SZRD1	MONDO:excludeGene	FALSE
 OMIM:620684	HGH1	MONDO:excludeGene	FALSE
 OMIM:620685	C19ORF53	MONDO:excludeGene	FALSE
+OMIMPS:151623	Li-Fraumeni syndrome	MONDO:excludeGrouping	FALSE
diff --git a/src/ontology/config/ordo_exclusions.tsv b/src/ontology/config/ordo_exclusions.tsv
index 12fe75c1..7ce70eab 100644
--- a/src/ontology/config/ordo_exclusions.tsv
+++ b/src/ontology/config/ordo_exclusions.tsv
@@ -171,4 +171,9 @@ Orphanet:522512	Rare genetic optic nerve disorder	FALSE	MONDO:excludeGroupingOri
 Orphanet:519321	Syndromic chorioretinal dystrophy	FALSE	MONDO:excludeGroupingModifier
 Orphanet:522548	Syndromic genetic cataract	FALSE	MONDO:excludeGroupingOriginGenetic|MONDO:excludeGroupingModifier
 Orphanet:522554	Syndromic genetic ectopia lentis	FALSE	MONDO:excludeGroupingOriginGenetic|MONDO:excludeGroupingModifier
-Orphanet:522564	Syndromic genetic keratoconus	FALSE	MONDO:excludeGroupingOriginGenetic|MONDO:excludeGroupingModifier
\ No newline at end of file
+Orphanet:522564	Syndromic genetic keratoconus	FALSE	MONDO:excludeGroupingOriginGenetic|MONDO:excludeGroupingModifier
+Orphanet:522514	Congenital optic disc excavation of genetic origin	FALSE	MONDO:excludeGrouping
+Orphanet:522562	Genetic superficial corneal dystrophy	FALSE	MONDO:excludeGroupingOriginGenetic
+Orphanet:519337	Disorder with optic nerve compression	FALSE	MONDO:excludeGroupingPhenotype
+Orphanet:522520	Syndromic genetic disorder with strabismus	FALSE	MONDO:excludeGroupingPhenotype
+Orphanet:522530	Rare genetic disorder with entropion	FALSE	MONDO:excludeGroupingPhenotype
\ No newline at end of file