diff --git a/backend/src/openarchiefbeheer/destruction/api/serializers.py b/backend/src/openarchiefbeheer/destruction/api/serializers.py
index fc825618..64f30259 100644
--- a/backend/src/openarchiefbeheer/destruction/api/serializers.py
+++ b/backend/src/openarchiefbeheer/destruction/api/serializers.py
@@ -114,12 +114,19 @@ def validate(self, attrs):
             .assignees.filter(role=ListRole.co_reviewer)
             .count()
         )
-        if (
-            current_number_co_reviewers
-            + len(attrs.get("add", []))
-            - len(attrs.get("remove", []))
-            > MAX_NUMBER_CO_REVIEWERS
-        ):
+
+        # (New) number of co reviewers depends on whether a partial update has been mode or a full update is provided.
+        number_of_co_reviewers = (
+            (
+                current_number_co_reviewers
+                + len(attrs.get("add", []))
+                - len(attrs.get("remove", []))
+            )
+            if self.partial
+            else len(attrs.get("add", []))
+        )
+
+        if number_of_co_reviewers > MAX_NUMBER_CO_REVIEWERS:
             raise ValidationError(
                 _("The maximum number of allowed co-reviewers is %(max_co_reviewers)s.")
                 % {"max_co_reviewers": MAX_NUMBER_CO_REVIEWERS}
diff --git a/frontend/src/components/DestructionListReviewer/DestructionListReviewer.tsx b/frontend/src/components/DestructionListReviewer/DestructionListReviewer.tsx
index a932be80..c4cf9676 100644
--- a/frontend/src/components/DestructionListReviewer/DestructionListReviewer.tsx
+++ b/frontend/src/components/DestructionListReviewer/DestructionListReviewer.tsx
@@ -3,11 +3,13 @@ import {
   Button,
   FormField,
   P,
+  SerializedFormData,
   Solid,
   useAlert,
   useFormDialog,
+  validateForm,
 } from "@maykin-ui/admin-ui";
-import { useMemo } from "react";
+import { useEffect, useMemo, useState } from "react";
 import { useNavigation, useRevalidator } from "react-router-dom";
 
 import {
@@ -57,11 +59,41 @@ export function DestructionListReviewer({
   const assignedCoReviewers = useDestructionListCoReviewers(destructionList);
   const user = useWhoAmI();
 
+  const [
+    assignCoReviewersFormValuesState,
+    setAssignCoReviewersFormValuesState,
+  ] = useState<SerializedFormData>({});
+
+  useEffect(() => {
+    setAssignCoReviewersFormValuesState({
+      ...assignCoReviewersFormValuesState,
+      coReviewer: assignedCoReviewers.map((r) => r.user.pk.toString()),
+    });
+  }, [assignedCoReviewers]);
+
+  const [assignCoReviewerModalOpenState, setAssignCoReviewerModalOpenState] =
+    useState(false);
+
+  /**
+   * Updates `assignCoReviewersFormValuesState` with `values`.
+   * This allows `field` to use filtered options based on it's value.
+   * @param values
+   */
+  const handleValidate = (values: SerializedFormData) => {
+    // Ignore first run.
+    if (!Object.keys(values).length) {
+      return;
+    }
+    setAssignCoReviewersFormValuesState(values);
+    return validateForm(values, fields);
+  };
+
   /**
    * Gets called when the change is confirmed.
    */
   const handleSubmit = (data: DestructionListReviewerFormType) => {
     const { coReviewer, reviewer, comment } = data;
+    setAssignCoReviewerModalOpenState(false);
 
     const promises: Promise<unknown>[] = [];
 
@@ -122,6 +154,10 @@ export function DestructionListReviewer({
     (assignee) => assignee.role === "main_reviewer",
   );
 
+  /**
+   * The fields to show in the form dialog, can be either for (re)assigning a
+   * reviewer or for (re)assigning co-reviewers.
+   */
   const fields = useMemo<FormField[]>(() => {
     if (!user) return [];
 
@@ -145,29 +181,58 @@ export function DestructionListReviewer({
       required: true,
     };
 
+    const activeCoReviewers =
+      (assignCoReviewersFormValuesState.coReviewer as string[]) || [];
+
     if (canReviewDestructionList(user, destructionList)) {
       const coReviewerFields = new Array(5)
         .fill({
           label: "Medebeoordelaar",
           name: "coReviewer",
           type: "string",
-          options: coReviewers.map((user) => ({
-            label: formatUser(user),
-            value: user.pk,
-          })),
           required: false,
         })
-        .map((f, i) => ({
-          ...f,
-          label: `Medebeoordelaar ${1 + i}`,
-          value: assignedCoReviewers[i]?.user.pk,
-        }));
+        .map((f, i) => {
+          return {
+            ...f,
+            label: `Medebeoordelaar ${1 + i}`,
+            value: activeCoReviewers?.[i],
+            options: coReviewers
+              // Don't show the co-reviewer as option if:
+              // - The co-reviewer is already selected AND
+              // - The co-reviewer is not selected as value for the current
+              //   field.
+              .filter((c) => {
+                const selectedIndex = activeCoReviewers.indexOf(
+                  c.pk.toString(),
+                );
+                if (selectedIndex < 0 || selectedIndex === i) {
+                  return true;
+                }
+                return false;
+              })
+              .map((user) => ({
+                label: formatUser(user),
+                value: user.pk,
+              })),
+          };
+        });
 
       return [...coReviewerFields, comment];
     }
     return [reviewer, comment];
-  }, [user, destructionList, reviewers, assignedCoReviewers]);
+  }, [
+    user,
+    destructionList,
+    reviewers,
+    assignedCoReviewers,
+    assignCoReviewersFormValuesState,
+  ]);
 
+  /**
+   * Contains the co-reviewers that are assigned to the destruction list as
+   * items for the AttributeTable.
+   */
   const coReviewerItems = useMemo(
     () =>
       assignedCoReviewers.reduce((acc, coReviewer, i) => {
@@ -194,6 +259,29 @@ export function DestructionListReviewer({
     [assignedCoReviewers, coReviews],
   );
 
+  /**
+   * Opens a dialog to assign a co-reviewer and updates it when `fields` change.
+   */
+  useEffect(() => {
+    formDialog(
+      "Beoordelaar toewijzen",
+      null,
+      fields,
+      "Toewijzen",
+      "Annuleren",
+      handleSubmit,
+      undefined,
+      {
+        allowClose: true,
+        open: assignCoReviewerModalOpenState,
+        onClose: () => setAssignCoReviewerModalOpenState(false),
+      },
+      {
+        validate: handleValidate,
+      },
+    );
+  }, [assignCoReviewerModalOpenState, fields]);
+
   return (
     <>
       {reviewer && (
@@ -217,18 +305,9 @@ export function DestructionListReviewer({
                             }
                             size="xs"
                             variant="secondary"
-                            onClick={(e) => {
-                              formDialog(
-                                "Beoordelaar toewijzen",
-                                null,
-                                fields,
-                                "Toewijzen",
-                                "Annuleren",
-                                handleSubmit,
-                                undefined,
-                                { allowClose: true },
-                              );
-                            }}
+                            onClick={() =>
+                              setAssignCoReviewerModalOpenState(true)
+                            }
                           >
                             <Solid.PencilIcon />
                           </Button>