diff --git a/_bibliography/papers.bib b/_bibliography/papers.bib index e73b7b3..1a18f6c 100644 --- a/_bibliography/papers.bib +++ b/_bibliography/papers.bib @@ -7,40 +7,41 @@ @PHDTHESIS{Attia2021-fy catalysis and separations. Recently, additive manufacturing has allowed for the design of structured mesoscale porous structures, including open cellular structures and lattices,which can be used - for applications ranging from biomedical implants to drug - delivery to aeroelastic wing design. These structures have also - garnered interest as a means to generate ordered porous media - which can exhibit desired surface properties and imparts - predictability. However, limited work has investigated the flow - dynamics through these structures. This thesis leveraged - computational fluid dynamics (CFD) as a tool to simulate fluid - flow through open cellular structures. The flow phenomena through - individual unit cells was investigated, and flow conditioning - through unit cell pores was observed. The influence of unit cell - geometry and flow conditions on pressure drop was also - investigated for cubic unit cells. Theoretical model fits were - evaluated, and it was found that the Darcy-Weisbach model may be - a useful tool to evaluate pressure drop over individual unit - cells. Pressure drop was shown to be decoupled for cubic unit - cells under laminar flow in lattice structures, suggesting the - feasibility of implementing optimization for the design of - lattice structures with specific flow dynamics. Finally, a - portable optimization workflow was developed to optimize lattice - designs with a minimum pressure drop.", + for applications ranging from biomedical implants to drug delivery + to aeroelastic wing design. These structures have also garnered + interest as a means to generate ordered porous media which can + exhibit desired surface properties and imparts predictability. + However, limited work has investigated the flow dynamics through + these structures. This thesis leveraged computational fluid + dynamics (CFD) as a tool to simulate fluid flow through open + cellular structures. The flow phenomena through individual unit + cells was investigated, and flow conditioning through unit cell + pores was observed. The influence of unit cell geometry and flow + conditions on pressure drop was also investigated for cubic unit + cells. Theoretical model fits were evaluated, and it was found + that the Darcy-Weisbach model may be a useful tool to evaluate + pressure drop over individual unit cells. Pressure drop was shown + to be decoupled for cubic unit cells under laminar flow in lattice + structures, suggesting the feasibility of implementing + optimization for the design of lattice structures with specific + flow dynamics. Finally, a portable optimization workflow was + developed to optimize lattice designs with a minimum pressure + drop.", month = may, year = 2021, - school = "University of Delaware", keywords = "Flow dynamics; Cellular structures; Porous media; Darcy-Weisbach - model;Website", - pdf = {LMA_Thesis.pdf}, - preview = {thesis.PNG} + model", + school = "University of Delaware" } @ARTICLE{Woodward2021-ka, - title = "Scalable 3D-printed lattices for pressure control in fluid + title = "Scalable {3D}-printed lattices for pressure control in fluid applications", - author = "Woodward, Ian R and Attia, Lucas and Patel, Premal and Fromen, + author = "Woodward, Ian R and Attia, Lucas M and Patel, Premal and Fromen, Catherine A", + journal = "AIChE J.", + volume = 67, + number = 12, abstract = "Additive manufacturing affords precise control over geometries with high degrees of complexity and pre-defined structure. Lattices are one class of additive-only structures which have @@ -56,26 +57,23 @@ @ARTICLE{Woodward2021-ka that a single correlation can describe pressure behavior for different lattice geometries and scales. Furthermore, combining lattice systems in series has a complex effect that is sensitive - to part geometry. Together, these developments support the - promise for tailored, modular lattice systems at laboratory - scales and beyond.", - journal = "AIChE J.", - volume = 67, - number = 12, + to part geometry. Together, these developments support the promise + for tailored, modular lattice systems at laboratory scales and + beyond.", month = dec, year = 2021, keywords = "3D printing; Fluid Mechanics; Transport Phenomena; lattices; open - cellular structures; pressure drop; scaling;Website", - language = "en", - pdf = {Scalable 3D-printed lattices for pressure control in fluid applications.pdf}, - preview = {pressure.PNG} + cellular structures; pressure drop; scaling", + language = "en" } @ARTICLE{Attia2023-bc, - title = "Orthogonal Gelations to Synthesize {Core-Shell} Hydrogels Loaded - with {Nanoemulsion-Templated} Drug Nanoparticles for Versatile - Oral Drug Delivery", + title = "Orthogonal Gelations to Synthesize Core-Shell Hydrogels Loaded + with Nanoemulsion-Templated Drug Nanoparticles for Versatile Oral + Drug Delivery", author = "Attia, Lucas and Chen, Liang-Hsun and Doyle, Patrick S", + journal = "Adv. Healthc. Mater.", + pages = "e2301667", abstract = "Hydrophobic active pharmaceutical ingredients are ubiquitous in the drug development pipeline, but their poor bioavailability often prevents their translation into drug products. Industrial @@ -83,8 +81,8 @@ @ARTICLE{Attia2023-bc to optimize, and not flexible enough to incorporate customizable drug release profiles into drug products. Here, a novel, dual-responsive gelation process that exploits orthogonal - thermo-responsive and ion-responsive gelations is introduced. - This one-step ``dual gelation'' synthesizes core-shell + thermo-responsive and ion-responsive gelations is introduced. This + one-step ``dual gelation'' synthesizes core-shell (methylcellulose-alginate) hydrogel particles and encapsulates drug-laden nanoemulsions in the hydrogel matrices. In situ crystallization templates drug nanocrystals inside the polymeric @@ -101,35 +99,32 @@ @ARTICLE{Attia2023-bc suggests and applies a novel method to leverage orthogonal gel chemistries to generate functional core-shell hydrogel particles. This article is protected by copyright. All rights reserved.", - journal = "Adv. Healthc. Mater.", - pages = "e2301667", month = jul, year = 2023, keywords = "drug delivery; hydrogels; nanocrystals; nanoemulsions; - stimuli-responsive materials;Website;md\_paper", - language = "en", - pdf = {Adv Healthcare Materials - 2023 - Attia.pdf}, - preview = {TOC.png} + stimuli-responsive materials", + language = "en" } -% The entry below contains non-ASCII chars that could not be converted -% to a LaTeX equivalent. @ARTICLE{Jarai2020-tn, - title = "Evaluating {UiO-66} {Metal-Organic} Framework Nanoparticles as - {Acid-Sensitive} Carriers for Pulmonary Drug Delivery - Applications", + title = "Evaluating {UiO}-66 Metal-Organic Framework Nanoparticles as + Acid-Sensitive Carriers for Pulmonary Drug Delivery Applications", author = "Jarai, Bader M and Stillman, Zachary and Attia, Lucas and Decker, Gerald E and Bloch, Eric D and Fromen, Catherine A", - abstract = "Developing novel drug carriers for pulmonary delivery is - necessary to achieve higher efficacy and consistency for treating - pulmonary diseases while limiting off-target side effects that - occur from alternative routes of administration. Metal-organic - frameworks (MOFs) have recently emerged as a class of materials - with characteristics well-suited for pulmonary drug delivery, - with chemical tunability, high surface area, and pore size, which - will allow for efficient loading of therapeutic cargo and deep - lung penetration. UiO-66, a zirconium and terephthalic acid-based - MOF, has displayed notable chemical and physical stability and + journal = "ACS Appl. Mater. Interfaces", + volume = 12, + number = 35, + pages = "38989--39004", + abstract = "Developing novel drug carriers for pulmonary delivery is necessary + to achieve higher efficacy and consistency for treating pulmonary + diseases while limiting off-target side effects that occur from + alternative routes of administration. Metal-organic frameworks + (MOFs) have recently emerged as a class of materials with + characteristics well-suited for pulmonary drug delivery, with + chemical tunability, high surface area, and pore size, which will + allow for efficient loading of therapeutic cargo and deep lung + penetration. UiO-66, a zirconium and terephthalic acid-based MOF, + has displayed notable chemical and physical stability and potential biocompatibility; however, its feasibility for use as a pulmonary drug delivery vehicle has yet to be examined. Here, we evaluate the use of UiO-66 nanoparticles (NPs) as novel pulmonary @@ -140,40 +135,37 @@ @ARTICLE{Jarai2020-tn cargo, cargo release, biocompatibility, or biodistribution. This is a critical result, as it indicates the robust consistency of UiO-66, a critical feature for pulmonary drug delivery, which is - plagued by inconsistent dosage because of variable properties. - Not only that, but UiO-66 NPs also demonstrate pH-dependent - stability, with resistance to degradation in extracellular - conditions and breakdown in intracellular environments. - Furthermore, the carriers exhibit high biocompatibility and low - cytotoxicity in vitro and are well-tolerated in in vivo murine - evaluations of orotracheally administered NPs. Following - pulmonary delivery, UiO-66 NPs remain localized to the lungs - before clearance over the course of seven days. Our results - demonstrate the feasibility of using UiO-66 NPs as a novel - platform for pulmonary drug delivery through their tunable NP - properties, which allow for controlled aerodynamics and + plagued by inconsistent dosage because of variable properties. Not + only that, but UiO-66 NPs also demonstrate pH-dependent stability, + with resistance to degradation in extracellular conditions and + breakdown in intracellular environments. Furthermore, the carriers + exhibit high biocompatibility and low cytotoxicity in vitro and + are well-tolerated in in vivo murine evaluations of orotracheally + administered NPs. Following pulmonary delivery, UiO-66 NPs remain + localized to the lungs before clearance over the course of seven + days. Our results demonstrate the feasibility of using UiO-66 NPs + as a novel platform for pulmonary drug delivery through their + tunable NP properties, which allow for controlled aerodynamics and internalization-dependent cargo release while displaying remarkable pulmonary biocompatibility.", - journal = "ACS Appl. Mater. Interfaces", - volume = 12, - number = 35, - pages = "38989--39004", month = sep, year = 2020, keywords = "UiO-66; aerosols; defectiveness; metal−organic frameworks; - nanoparticles; pulmonary drug delivery;Website", - language = "en", - pdf = {Evaluating UiO-66 Metal−Organic Framework Nanoparticles as Acid-Sensitive Carriers.pdf}, - preview = {appliedmaterials.gif} + nanoparticles; pulmonary drug delivery", + language = "en" } @ARTICLE{Decker2019-kv, title = "Controlling Size, Defectiveness, and Fluorescence in Nanoparticle - {UiO-66} Through Water and Ligand Modulation", + {UiO}-66 Through Water and Ligand Modulation", author = "Decker, Gerald E and Stillman, Zachary and Attia, Lucas and Fromen, Catherine A and Bloch, Eric D", - abstract = "UiO-66, a zirconium(IV) metal-organic framework (MOF) comprised - of six-metal clusters and terephthalic acid ligands, displays + journal = "Chem. Mater.", + volume = 31, + number = 13, + pages = "4831--4839", + abstract = "UiO-66, a zirconium(IV) metal-organic framework (MOF) comprised of + six-metal clusters and terephthalic acid ligands, displays excellent thermal and chemical stability and has functions in gas storage, catalysis, selective adsorption, and drug delivery. Though the stability of UiO-66 is highly advantageous, @@ -188,75 +180,15 @@ @ARTICLE{Decker2019-kv 120 nm, while maintaining high crystallinity in the nanoparticles that were formed. We also find that particle defectiveness is linked to common over-estimation of particle size measurements - obtained via dynamic light scattering (DLS) and propose a model - to correct elevated hydrodynamic diameter measurements. Finally, - we report inherent fluorescence of non-functionalized UiO-66, - which exhibits peak fluorescence at a wavelength of 390 nm - following excitation at 280 nm and is maximized in large, - defect-free particles. Overall, this synthetic approach and - characterization of defect, size, and fluorescence represent new - opportunities to tune the physiochemical properties of UiO-66.", - journal = "Chem. Mater.", - volume = 31, - number = 13, - pages = "4831--4839", + obtained via dynamic light scattering (DLS) and propose a model to + correct elevated hydrodynamic diameter measurements. Finally, we + report inherent fluorescence of non-functionalized UiO-66, which + exhibits peak fluorescence at a wavelength of 390 nm following + excitation at 280 nm and is maximized in large, defect-free + particles. Overall, this synthetic approach and characterization + of defect, size, and fluorescence represent new opportunities to + tune the physiochemical properties of UiO-66.", month = jul, year = 2019, - keywords = "Website", - language = "en", - pdf = {Controlling Size, Defectiveness, and Fluorescence in Nanoparticle UiO-66.pdf}, - preview = {chemmat.gif} -} - - -@ARTICLE{Attia2024-qn, - title = "{Surfactant-Polymer} Complexation and Competition on Drug - Nanocrystal Surfaces Control Crystallinity", - author = "Attia, Lucas and Nguyen, Dien and Gokhale, Devashish and Zheng, - Talia and Doyle, Patrick S", - abstract = "Nanosizing drug crystals has emerged as a successful approach to - enabling oral bioavailability, as increasing drug crystal surface - area improves dissolution kinetics and effective solubility. - Recently, bottom-up methods have been developed to directly - assemble nanosized crystals by leveraging polymer and surfactant - excipients during crystallization to control crystal size, - morphology, and structure. However, while significant research - has investigated how polymers and other single additives inhibit - or promote crystallization in pharmaceutical systems, there is - little work studying the mechanistic interactions of multiple - excipients on drug crystal structure and the extent of - crystallinity, which can influence formulation performance. This - study explores how the structure and crystallinity of a model - hydrophobic drug crystal, fenofibrate, change as a result of - competitive interfacial chemisorption between common nonionic - surfactants (polysorbate 80 and sorbitan monooleate) and a - surface-active polymer excipient (methylcellulose). Classical - molecular dynamics simulations highlight how key intermolecular - interactions, including surfactant-polymer complexation and - surfactant screening of the crystal surface, modify the resulting - crystal structure. In parallel, experiments generating drug - nanocrystals in hydrogel thin films validate that drug - crystallinity increases with an increasing weight fraction of - surfactant. Simulation results reveal a connection between - accelerated dynamics in the bulk crystal and the experimentally - measured extent of crystallinity. To our knowledge, these are the - first simulations that directly characterize structural changes - in a drug crystal as a result of excipient surface composition - and relate the experimental extent of crystallinity to structural - changes in the molecular crystal. Our approach provides a - mechanistic understanding of crystallinity in - nanocrystallization, which can expand the range of orally - deliverable small molecule therapies.", - journal = "ACS Appl. Mater. Interfaces", - volume = 16, - number = 26, - pages = "34409--34418", - month = jul, - year = 2024, - keywords = "crystallinity; interfaces; molecular dynamics; nanoformulations; - polymers; surfactants", - language = "en", - pdf = {attia-et-al-2024-surfactant-polymer-complexation-and-competition-on-drug-nanocrystal-surfaces-control-crystallinity.pdf}, - preview = {TOC_ami.png} + language = "en" } -