From ae9e4d7e4303e7762a2f9c59c0eae1e5a9e260d6 Mon Sep 17 00:00:00 2001 From: Lucas Attia <43359170+lucasattia@users.noreply.github.com> Date: Mon, 16 Sep 2024 13:59:38 -0400 Subject: [PATCH] Update papers._backup.bib --- _bibliography/papers._backup.bib | 133 +++++++++++++++---------------- 1 file changed, 64 insertions(+), 69 deletions(-) diff --git a/_bibliography/papers._backup.bib b/_bibliography/papers._backup.bib index 315fde4..1c53c1d 100644 --- a/_bibliography/papers._backup.bib +++ b/_bibliography/papers._backup.bib @@ -1,3 +1,54 @@ +@ARTICLE{Attia2024-qn, + title = "{Surfactant-Polymer} Complexation and Competition on Drug + Nanocrystal Surfaces Control Crystallinity", + author = "Attia, Lucas and Nguyen, Dien and Gokhale, Devashish and Zheng, + Talia and Doyle, Patrick S", + abstract = "Nanosizing drug crystals has emerged as a successful approach to + enabling oral bioavailability, as increasing drug crystal surface + area improves dissolution kinetics and effective solubility. + Recently, bottom-up methods have been developed to directly + assemble nanosized crystals by leveraging polymer and surfactant + excipients during crystallization to control crystal size, + morphology, and structure. However, while significant research + has investigated how polymers and other single additives inhibit + or promote crystallization in pharmaceutical systems, there is + little work studying the mechanistic interactions of multiple + excipients on drug crystal structure and the extent of + crystallinity, which can influence formulation performance. This + study explores how the structure and crystallinity of a model + hydrophobic drug crystal, fenofibrate, change as a result of + competitive interfacial chemisorption between common nonionic + surfactants (polysorbate 80 and sorbitan monooleate) and a + surface-active polymer excipient (methylcellulose). Classical + molecular dynamics simulations highlight how key intermolecular + interactions, including surfactant-polymer complexation and + surfactant screening of the crystal surface, modify the resulting + crystal structure. In parallel, experiments generating drug + nanocrystals in hydrogel thin films validate that drug + crystallinity increases with an increasing weight fraction of + surfactant. Simulation results reveal a connection between + accelerated dynamics in the bulk crystal and the experimentally + measured extent of crystallinity. To our knowledge, these are the + first simulations that directly characterize structural changes + in a drug crystal as a result of excipient surface composition + and relate the experimental extent of crystallinity to structural + changes in the molecular crystal. Our approach provides a + mechanistic understanding of crystallinity in + nanocrystallization, which can expand the range of orally + deliverable small molecule therapies.", + journal = "ACS Appl. Mater. Interfaces", + volume = 16, + number = 26, + pages = "34409--34418", + month = jul, + year = 2024, + keywords = "crystallinity; interfaces; molecular dynamics; nanoformulations; + polymers; surfactants", + language = "en", + pdf = {attia-et-al-2024-surfactant-polymer-complexation-and-competition-on-drug-nanocrystal-surfaces-control-crystallinity.pdf}, + preview = {TOC_ami.png} +} + @PHDTHESIS{Attia2021-fy, title = "Computational Modeling Of Fluid Flow Through Open Cellular Structures", @@ -32,15 +83,14 @@ @PHDTHESIS{Attia2021-fy school = "University of Delaware", keywords = "Flow dynamics; Cellular structures; Porous media; Darcy-Weisbach model;Website", - url={https://udspace.udel.edu/handle/19716/31000}, - pdf={LMA Thesis.pdf}, + pdf = {LMA_Thesis.pdf}, preview = {thesis.PNG} } @ARTICLE{Woodward2021-ka, title = "Scalable 3D-printed lattices for pressure control in fluid applications", - author = "Woodward, Ian R and Attia, Lucas M and Patel, Premal and Fromen, + author = "Woodward, Ian R and Attia, Lucas and Patel, Premal and Fromen, Catherine A", abstract = "Additive manufacturing affords precise control over geometries with high degrees of complexity and pre-defined structure. @@ -67,11 +117,9 @@ @ARTICLE{Woodward2021-ka year = 2021, keywords = "3D printing; Fluid Mechanics; Transport Phenomena; lattices; open cellular structures; pressure drop; scaling;Website", - language = "en", - doi={10.1002/aic.17452}, - url={https://aiche.onlinelibrary.wiley.com/doi/abs/10.1002/aic.17452}, - pdf={Scalable 3D-printed lattices for pressure control in fluid applications.pdf}, - preview = {pressure.jpg} + language = "en", + pdf = {Scalable 3D-printed lattices for pressure control in fluid applications.pdf}, + preview = {pressure.PNG} } @ARTICLE{Attia2023-bc, @@ -109,10 +157,10 @@ @ARTICLE{Attia2023-bc month = jul, year = 2023, keywords = "drug delivery; hydrogels; nanocrystals; nanoemulsions; - stimuli-responsive materials;Website", - language = "en", - url={https://onlinelibrary.wiley.com/doi/10.1002/adhm.202301667}, - preview={TOC.png} + stimuli-responsive materials;Website;md\_paper", + language = "en", + pdf = {Adv Healthcare Materials - 2023 - Attia.pdf}, + preview = {TOC.png} } % The entry below contains non-ASCII chars that could not be converted @@ -165,9 +213,8 @@ @ARTICLE{Jarai2020-tn year = 2020, keywords = "UiO-66; aerosols; defectiveness; metal−organic frameworks; nanoparticles; pulmonary drug delivery;Website", - language = "en", - url={https://pubs.acs.org/doi/abs/10.1021/acsami.0c10900}, - pdf={Evaluating UiO-66 Metal−Organic Framework Nanoparticles as Acid-Sensitive Carriers.pdf}, + language = "en", + pdf = {Evaluating UiO-66 Metal−Organic Framework Nanoparticles as Acid-Sensitive Carriers.pdf}, preview = {appliedmaterials.gif} } @@ -207,59 +254,7 @@ @ARTICLE{Decker2019-kv month = jul, year = 2019, keywords = "Website", - language = "en", - url={https://pubs.acs.org/doi/abs/10.1021/acs.chemmater.9b01383}, - pdf={Controlling Size, Defectiveness, and Fluorescence in Nanoparticle UiO-66.pdf}, - preview = {chemmat.gif} -} - - -@ARTICLE{Attia2024-qn, - title = "{Surfactant-Polymer} Complexation and Competition on Drug - Nanocrystal Surfaces Control Crystallinity", - author = "Attia, Lucas and Nguyen, Dien and Gokhale, Devashish and Zheng, - Talia and Doyle, Patrick S", - abstract = "Nanosizing drug crystals has emerged as a successful approach to - enabling oral bioavailability, as increasing drug crystal surface - area improves dissolution kinetics and effective solubility. - Recently, bottom-up methods have been developed to directly - assemble nanosized crystals by leveraging polymer and surfactant - excipients during crystallization to control crystal size, - morphology, and structure. However, while significant research - has investigated how polymers and other single additives inhibit - or promote crystallization in pharmaceutical systems, there is - little work studying the mechanistic interactions of multiple - excipients on drug crystal structure and the extent of - crystallinity, which can influence formulation performance. This - study explores how the structure and crystallinity of a model - hydrophobic drug crystal, fenofibrate, change as a result of - competitive interfacial chemisorption between common nonionic - surfactants (polysorbate 80 and sorbitan monooleate) and a - surface-active polymer excipient (methylcellulose). Classical - molecular dynamics simulations highlight how key intermolecular - interactions, including surfactant-polymer complexation and - surfactant screening of the crystal surface, modify the resulting - crystal structure. In parallel, experiments generating drug - nanocrystals in hydrogel thin films validate that drug - crystallinity increases with an increasing weight fraction of - surfactant. Simulation results reveal a connection between - accelerated dynamics in the bulk crystal and the experimentally - measured extent of crystallinity. To our knowledge, these are the - first simulations that directly characterize structural changes - in a drug crystal as a result of excipient surface composition - and relate the experimental extent of crystallinity to structural - changes in the molecular crystal. Our approach provides a - mechanistic understanding of crystallinity in - nanocrystallization, which can expand the range of orally - deliverable small molecule therapies.", - journal = "ACS Appl. Mater. Interfaces", - volume = 16, - number = 26, - pages = "34409--34418", - month = jul, - year = 2024, - keywords = "crystallinity; interfaces; molecular dynamics; nanoformulations; - polymers; surfactants", - language = "en" + language = "en", + pdf = {Controlling Size, Defectiveness, and Fluorescence in Nanoparticle UiO-66.pdf}, preview = {chemmat.gif} }