diff --git a/ee/tuf/autoupdate.go b/ee/tuf/autoupdate.go
index b8aaa52c9..9bf34159f 100644
--- a/ee/tuf/autoupdate.go
+++ b/ee/tuf/autoupdate.go
@@ -328,9 +328,12 @@ func (ta *TufAutoupdater) checkForUpdate() error {
 
 	// If launcher was updated, we want to exit and reload
 	if updatedVersion, ok := updatesDownloaded[binaryLauncher]; ok {
-		level.Debug(ta.logger).Log("msg", "launcher updated -- exiting to load new version", "new_binary_version", updatedVersion)
-		ta.signalRestart <- NewLauncherReloadNeededErr(updatedVersion)
-		return nil
+		// Only reload if we're not using a localdev path
+		if ta.knapsack.LocalDevelopmentPath() == "" {
+			level.Debug(ta.logger).Log("msg", "launcher updated -- exiting to load new version", "new_binary_version", updatedVersion)
+			ta.signalRestart <- NewLauncherReloadNeededErr(updatedVersion)
+			return nil
+		}
 	}
 
 	// For non-launcher binaries (i.e. osqueryd), call any reload functions we have saved
diff --git a/ee/tuf/autoupdate_test.go b/ee/tuf/autoupdate_test.go
index b45a6246f..207754feb 100644
--- a/ee/tuf/autoupdate_test.go
+++ b/ee/tuf/autoupdate_test.go
@@ -73,6 +73,7 @@ func TestExecute_launcherUpdate(t *testing.T) {
 	mockKnapsack.On("TufServerURL").Return(tufServerUrl)
 	mockKnapsack.On("UpdateDirectory").Return("")
 	mockKnapsack.On("MirrorServerURL").Return("https://example.com")
+	mockKnapsack.On("LocalDevelopmentPath").Return("")
 	mockQuerier := newMockQuerier(t)
 
 	// Set up autoupdater
diff --git a/ee/tuf/finalize_linux.go b/ee/tuf/finalize_linux.go
new file mode 100644
index 000000000..395eb5fc4
--- /dev/null
+++ b/ee/tuf/finalize_linux.go
@@ -0,0 +1,69 @@
+//go:build linux
+// +build linux
+
+package tuf
+
+import (
+	"context"
+	"fmt"
+	"os"
+	"strings"
+	"time"
+
+	"github.com/kolide/launcher/pkg/allowedcmd"
+)
+
+// patchExecutable updates the downloaded binary as necessary for it to be able to
+// run on this system. On NixOS, we have to set the interpreter for any non-NixOS
+// executable we want to run.
+// See: https://unix.stackexchange.com/a/522823
+func patchExecutable(executableLocation string) error {
+	if !allowedcmd.IsNixOS() {
+		return nil
+	}
+
+	interpreter, err := getInterpreter(executableLocation)
+	if err != nil {
+		return fmt.Errorf("getting interpreter for %s: %w", executableLocation, err)
+	}
+
+	ctx, cancel := context.WithTimeout(context.Background(), 5*time.Second)
+	defer cancel()
+
+	cmd, err := allowedcmd.Patchelf(ctx, "--set-interpreter", interpreter, executableLocation)
+	if err != nil {
+		return fmt.Errorf("creating patchelf command: %w", err)
+	}
+
+	if out, err := cmd.CombinedOutput(); err != nil {
+		return fmt.Errorf("running patchelf: output `%s`, error `%w`", string(out), err)
+	}
+
+	return nil
+}
+
+// getInterpreter asks patchelf what the interpreter is for the current running
+// executable, assuming that's a reasonable choice given that the current executable
+// is able to run.
+func getInterpreter(executableLocation string) (string, error) {
+	currentExecutable, err := os.Executable()
+	if err != nil {
+		return "", fmt.Errorf("getting current running executable: %w", err)
+	}
+
+	ctx, cancel := context.WithTimeout(context.Background(), 5*time.Second)
+	defer cancel()
+
+	cmd, err := allowedcmd.Patchelf(ctx, "--print-interpreter", currentExecutable)
+	if err != nil {
+		return "", fmt.Errorf("creating patchelf command: %w", err)
+	}
+
+	out, err := cmd.CombinedOutput()
+	if err != nil {
+		return "", fmt.Errorf("running patchelf: output `%s`, error `%w`", string(out), err)
+
+	}
+
+	return strings.TrimSpace(string(out)), nil
+}
diff --git a/ee/tuf/finalize_other.go b/ee/tuf/finalize_other.go
new file mode 100644
index 000000000..b645ffbfe
--- /dev/null
+++ b/ee/tuf/finalize_other.go
@@ -0,0 +1,8 @@
+//go:build !linux
+// +build !linux
+
+package tuf
+
+func patchExecutable(executableLocation string) error {
+	return nil
+}
diff --git a/ee/tuf/finalize_other_test.go b/ee/tuf/finalize_other_test.go
new file mode 100644
index 000000000..8458c18a4
--- /dev/null
+++ b/ee/tuf/finalize_other_test.go
@@ -0,0 +1,17 @@
+//go:build !linux
+// +build !linux
+
+package tuf
+
+import (
+	"testing"
+
+	"github.com/stretchr/testify/require"
+)
+
+func Test_patchExecutable(t *testing.T) {
+	t.Parallel()
+
+	// patchExecutable is a no-op on windows and darwin
+	require.NoError(t, patchExecutable(""))
+}
diff --git a/ee/tuf/library_manager.go b/ee/tuf/library_manager.go
index 269934799..bd01ff61f 100644
--- a/ee/tuf/library_manager.go
+++ b/ee/tuf/library_manager.go
@@ -201,6 +201,11 @@ func (ulm *updateLibraryManager) moveVerifiedUpdate(binary autoupdatableBinary,
 		return fmt.Errorf("could not set +x permissions on executable: %w", err)
 	}
 
+	// If necessary, patch the executable (NixOS only)
+	if err := patchExecutable(executableLocation(stagedVersionedDirectory, binary)); err != nil {
+		return fmt.Errorf("could not patch executable: %w", err)
+	}
+
 	// Validate the executable
 	if err := autoupdate.CheckExecutable(context.TODO(), executableLocation(stagedVersionedDirectory, binary), "--version"); err != nil {
 		return fmt.Errorf("could not verify executable: %w", err)
diff --git a/pkg/allowedcmd/cmd.go b/pkg/allowedcmd/cmd.go
index eb054b761..128908a51 100644
--- a/pkg/allowedcmd/cmd.go
+++ b/pkg/allowedcmd/cmd.go
@@ -6,7 +6,6 @@ import (
 	"os"
 	"os/exec"
 	"path/filepath"
-	"runtime"
 )
 
 type AllowedCommand func(ctx context.Context, arg ...string) (*exec.Cmd, error)
@@ -38,14 +37,25 @@ func validatedCommand(ctx context.Context, knownPath string, arg ...string) (*ex
 }
 
 func allowSearchPath() bool {
-	if runtime.GOOS != "linux" {
-		return false
+	return IsNixOS()
+}
+
+// Save results of lookup so we don't have to stat for /etc/NIXOS every time
+// we want to know.
+var (
+	checkedIsNixOS = false
+	isNixOS        = false
+)
+
+func IsNixOS() bool {
+	if checkedIsNixOS {
+		return isNixOS
 	}
 
-	// We only allow searching for binaries in PATH on NixOS
 	if _, err := os.Stat("/etc/NIXOS"); err == nil {
-		return true
+		isNixOS = true
 	}
 
-	return false
+	checkedIsNixOS = true
+	return isNixOS
 }
diff --git a/pkg/allowedcmd/cmd_linux.go b/pkg/allowedcmd/cmd_linux.go
index 4923644ed..35c08d78e 100644
--- a/pkg/allowedcmd/cmd_linux.go
+++ b/pkg/allowedcmd/cmd_linux.go
@@ -95,6 +95,10 @@ func Pacman(ctx context.Context, arg ...string) (*exec.Cmd, error) {
 	return validatedCommand(ctx, "/usr/bin/pacman", arg...)
 }
 
+func Patchelf(ctx context.Context, arg ...string) (*exec.Cmd, error) {
+	return validatedCommand(ctx, "/run/current-system/sw/bin/patchelf", arg...)
+}
+
 func Ps(ctx context.Context, arg ...string) (*exec.Cmd, error) {
 	return validatedCommand(ctx, "/usr/bin/ps", arg...)
 }