GitHub Metabolic coverage analysis.ipynb

{
 "cells": [
  {
   "cell_type": "code",
   "execution_count": 1,
   "id": "respiratory-florida",
   "metadata": {},
   "outputs": [],
   "source": [
    "import plotly\n",
    "import plotly.express as px\n",
    "import plotly.graph_objs as go\n",
    "import matplotlib.pyplot as plt\n",
    "import numpy as np\n",
    "import pandas as pd\n",
    "import string\n",
    "import re\n",
    "import csv\n",
    "from pandas import DataFrame"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 271,
   "id": "wrapped-blend",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "0                                1B18_HUMAN\n",
       "1                                2AAA_HUMAN\n",
       "2                                2AAB_HUMAN\n",
       "3       4EBP2_HUMAN;4EBP1_HUMAN;4EBP3_HUMAN\n",
       "4                                6PGD_HUMAN\n",
       "                       ...                 \n",
       "2642                             BRK1_HUMAN\n",
       "2643                            PDZD2_HUMAN\n",
       "2644                            SQSTM_HUMAN\n",
       "2645                            VP26A_HUMAN\n",
       "2646                            CC149_HUMAN\n",
       "Name: IDs, Length: 2647, dtype: object"
      ]
     },
     "execution_count": 271,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "#Finding proteins which overlap between dataset and Human1.\n",
    "#Upload dataset proteins:\n",
    "OC_dataset = pd.read_csv(r'/Users/katemeeson/Desktop/Workbook30.csv')\n",
    "OC_dataset = OC_dataset.iloc[:,0]\n",
    "OC_dataset"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 272,
   "id": "continent-ticket",
   "metadata": {},
   "outputs": [],
   "source": [
    "#Separate strings according to \";\", where there are multiple protein names on same row. \n",
    "OC_dataset2 = []\n",
    "\n",
    "for i in range(2647):\n",
    "    OC_dataset2.append(OC_dataset.iloc[i].split(\";\"))"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 273,
   "id": "quiet-departure",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "2647"
      ]
     },
     "execution_count": 273,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "#Check length of separated dataset matches with that which was uploaded.\n",
    "len(OC_dataset2)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 41,
   "id": "outstanding-batch",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "['CC149_HUMAN']"
      ]
     },
     "execution_count": 41,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "#Check last element in list matches with that shown when we uploaded list.\n",
    "#I.e. havent missed any in the range used to separate strings according to \";\".\n",
    "OC_dataset2[-1]"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 274,
   "id": "piano-telephone",
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "4EBP2_HUMAN\n",
      "4EBP1_HUMAN\n",
      "4EBP3_HUMAN\n"
     ]
    }
   ],
   "source": [
    "#Check you can access individual protein names from dataset, where before these were grouped with the \";\".\n",
    "#Shows separation was successful.\n",
    "for x in OC_dataset2[3]:\n",
    "    print(x)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 275,
   "id": "abroad-success",
   "metadata": {},
   "outputs": [
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "<ipython-input-275-2934c3e4350c>:5: FutureWarning: The default value of regex will change from True to False in a future version.\n",
      "  Updated_model.iloc[:,0] = Updated_model.iloc[:,0].str.replace(r'[^\\w\\s]+', '') #removes punctuation\n"
     ]
    },
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>UniprotID</th>\n",
       "      <th>ReactionID</th>\n",
       "      <th>ReactionRule</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>HOT_HUMAN ADH1G_HUMAN ADHX_HUMAN PTGR3_HUMAN A...</td>\n",
       "      <td>HMR_3905</td>\n",
       "      <td>Q8IWW8 or P28332 or Q8N4Q0 or P07327 or P40394...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>AK1A1_HUMAN</td>\n",
       "      <td>HMR_3907</td>\n",
       "      <td>P14550</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>ACSA_HUMAN</td>\n",
       "      <td>HMR_4097</td>\n",
       "      <td>Q9NR19</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>ACS2L_HUMAN ACSS3_HUMAN</td>\n",
       "      <td>HMR_4099</td>\n",
       "      <td>Q9H6R3 or Q9NUB1</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>ACSA_HUMAN</td>\n",
       "      <td>HMR_4108</td>\n",
       "      <td>Q9NR19</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>...</th>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>13082</th>\n",
       "      <td>NTCP_HUMAN</td>\n",
       "      <td>HMR_10119</td>\n",
       "      <td>Q14973</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>13083</th>\n",
       "      <td>NTCP_HUMAN</td>\n",
       "      <td>HMR_10120</td>\n",
       "      <td>Q14973</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>13088</th>\n",
       "      <td>MRP3_HUMAN ABCBB_HUMAN</td>\n",
       "      <td>HMR_10125</td>\n",
       "      <td>O95342 or O15438</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>13089</th>\n",
       "      <td>MRP3_HUMAN ABCBB_HUMAN</td>\n",
       "      <td>HMR_10126</td>\n",
       "      <td>O95342 or O15438</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>13090</th>\n",
       "      <td>NTCP_HUMAN</td>\n",
       "      <td>HMR_10127</td>\n",
       "      <td>Q14973</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>8036 rows × 3 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "                                               UniprotID ReactionID  \\\n",
       "0      HOT_HUMAN ADH1G_HUMAN ADHX_HUMAN PTGR3_HUMAN A...   HMR_3905   \n",
       "1                                            AK1A1_HUMAN   HMR_3907   \n",
       "2                                             ACSA_HUMAN   HMR_4097   \n",
       "3                                ACS2L_HUMAN ACSS3_HUMAN   HMR_4099   \n",
       "4                                             ACSA_HUMAN   HMR_4108   \n",
       "...                                                  ...        ...   \n",
       "13082                                         NTCP_HUMAN  HMR_10119   \n",
       "13083                                         NTCP_HUMAN  HMR_10120   \n",
       "13088                             MRP3_HUMAN ABCBB_HUMAN  HMR_10125   \n",
       "13089                             MRP3_HUMAN ABCBB_HUMAN  HMR_10126   \n",
       "13090                                         NTCP_HUMAN  HMR_10127   \n",
       "\n",
       "                                            ReactionRule  \n",
       "0      Q8IWW8 or P28332 or Q8N4Q0 or P07327 or P40394...  \n",
       "1                                                 P14550  \n",
       "2                                                 Q9NR19  \n",
       "3                                       Q9H6R3 or Q9NUB1  \n",
       "4                                                 Q9NR19  \n",
       "...                                                  ...  \n",
       "13082                                             Q14973  \n",
       "13083                                             Q14973  \n",
       "13088                                   O95342 or O15438  \n",
       "13089                                   O95342 or O15438  \n",
       "13090                                             Q14973  \n",
       "\n",
       "[8036 rows x 3 columns]"
      ]
     },
     "execution_count": 275,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "#Upload Human1 model. \n",
    "#Remove [] (and other punctuation) from UniprotID column.\n",
    "#Drop rows with empty cells for protein names.  \n",
    "Updated_model = pd.read_csv(r'/Users/katemeeson/Library/Mobile Documents/com~apple~CloudDocs/MRC-DTP PhD UoM/Modelling/Metabolic modelling/Datasets/updated_model_for_upload.csv')\n",
    "Updated_model.iloc[:,0] = Updated_model.iloc[:,0].str.replace(r'[^\\w\\s]+', '') #removes punctuation\n",
    "Updated_model = Updated_model.dropna()\n",
    "Updated_model"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 276,
   "id": "sorted-registrar",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "0        HOT_HUMAN ADH1G_HUMAN ADHX_HUMAN PTGR3_HUMAN A...\n",
       "1                                              AK1A1_HUMAN\n",
       "2                                               ACSA_HUMAN\n",
       "3                                  ACS2L_HUMAN ACSS3_HUMAN\n",
       "4                                               ACSA_HUMAN\n",
       "                               ...                        \n",
       "13082                                           NTCP_HUMAN\n",
       "13083                                           NTCP_HUMAN\n",
       "13088                               MRP3_HUMAN ABCBB_HUMAN\n",
       "13089                               MRP3_HUMAN ABCBB_HUMAN\n",
       "13090                                           NTCP_HUMAN\n",
       "Name: UniprotID, Length: 8036, dtype: object"
      ]
     },
     "execution_count": 276,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "#Create variable for the UniprotIDs column. To be compared against dataset proteins.\n",
    "model_ids = Updated_model.iloc[:,0]\n",
    "model_ids #Has same number of rows as model, so includes all protein names."
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 277,
   "id": "assumed-tongue",
   "metadata": {},
   "outputs": [],
   "source": [
    "#Split model_ids ready for comparison (some reactions have more than one essential protein).\n",
    "model_ids_2 = []\n",
    "\n",
    "for i in range(8036):\n",
    "    model_ids_2.append(model_ids.iloc[i].split())"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 278,
   "id": "absent-premises",
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "HOT_HUMAN\n",
      "ADH1G_HUMAN\n",
      "ADHX_HUMAN\n",
      "PTGR3_HUMAN\n",
      "ADH1B_HUMAN\n",
      "ADH1A_HUMAN\n",
      "ADH6_HUMAN\n",
      "ADH7_HUMAN\n",
      "ADH4_HUMAN\n",
      "Length:  9\n"
     ]
    }
   ],
   "source": [
    "#Check that each item in the new model ids list is properly accessible.\n",
    "for x in model_ids_2[0]:\n",
    "    print(x)\n",
    "\n",
    "print('Length: ', len(model_ids_2[0]))"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 284,
   "id": "legitimate-tuesday",
   "metadata": {},
   "outputs": [],
   "source": [
    "#Calculate overlap between dataset proteins and model proteins.\n",
    "overlap = []\n",
    "\n",
    "for i in range(8036):\n",
    "    for x in OC_dataset2:\n",
    "        for y in x:\n",
    "            if y in model_ids_2[i]:\n",
    "                overlap.append(y)\n",
    "            else:\n",
    "                continue\n"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 285,
   "id": "fifty-carter",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "5613"
      ]
     },
     "execution_count": 285,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "len(overlap)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 286,
   "id": "portable-setting",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "714"
      ]
     },
     "execution_count": 286,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "final_overlap = list(dict.fromkeys(overlap)) #Remove repeated protein names.\n",
    "len(final_overlap) #Check length of overlap."
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 287,
   "id": "laughing-agenda",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "['ADH7_HUMAN',\n",
       " 'ADHX_HUMAN',\n",
       " 'PTGR3_HUMAN',\n",
       " 'AK1A1_HUMAN',\n",
       " 'DLDH_HUMAN',\n",
       " 'ODP2_HUMAN',\n",
       " 'ODPA_HUMAN',\n",
       " 'ODPB_HUMAN',\n",
       " 'LDH6A_HUMAN',\n",
       " 'LDHA_HUMAN',\n",
       " 'LDHB_HUMAN',\n",
       " 'LDHC_HUMAN',\n",
       " 'AL1A3_HUMAN',\n",
       " 'ALDH2_HUMAN',\n",
       " 'AL7A1_HUMAN',\n",
       " 'AL1B1_HUMAN',\n",
       " 'AL9A1_HUMAN',\n",
       " 'PFKAP_HUMAN',\n",
       " 'PFKAM_HUMAN',\n",
       " 'PFKAL_HUMAN',\n",
       " 'ALDOB_HUMAN',\n",
       " 'ALDOA_HUMAN',\n",
       " 'ALDOC_HUMAN',\n",
       " 'KPYM_HUMAN',\n",
       " 'KPYR_HUMAN',\n",
       " 'ENOA_HUMAN',\n",
       " 'ENOG_HUMAN',\n",
       " 'ENOB_HUMAN',\n",
       " 'PGAM2_HUMAN',\n",
       " 'PGAM4_HUMAN',\n",
       " 'PGAM1_HUMAN',\n",
       " 'PGK1_HUMAN',\n",
       " 'PGK2_HUMAN',\n",
       " 'ACYP1_HUMAN',\n",
       " 'G3P_HUMAN',\n",
       " 'G3PT_HUMAN',\n",
       " 'G6PI_HUMAN',\n",
       " 'TPIS_HUMAN',\n",
       " 'HXK1_HUMAN',\n",
       " 'HXK2_HUMAN',\n",
       " 'PGM2_HUMAN',\n",
       " 'PGM1_HUMAN',\n",
       " 'LYAG_HUMAN',\n",
       " 'UGDH_HUMAN',\n",
       " 'GLYG_HUMAN',\n",
       " 'GYS1_HUMAN',\n",
       " 'GLGB_HUMAN',\n",
       " 'PYGB_HUMAN',\n",
       " 'PYGL_HUMAN',\n",
       " 'PYGM_HUMAN',\n",
       " 'UGPA_HUMAN',\n",
       " 'GALE_HUMAN',\n",
       " 'RL36A_HUMAN',\n",
       " 'ALDR_HUMAN',\n",
       " 'DHSO_HUMAN',\n",
       " 'PMM2_HUMAN',\n",
       " 'GMPPA_HUMAN',\n",
       " 'GMPPB_HUMAN',\n",
       " 'GMDS_HUMAN',\n",
       " 'FCL_HUMAN',\n",
       " 'TIGAR_HUMAN',\n",
       " 'ARK72_HUMAN',\n",
       " 'GLOD4_HUMAN',\n",
       " 'LGUL_HUMAN',\n",
       " 'MAOM_HUMAN',\n",
       " 'PCKGC_HUMAN',\n",
       " 'GRHPR_HUMAN',\n",
       " 'ACADM_HUMAN',\n",
       " 'DHC24_HUMAN',\n",
       " 'DHB11_HUMAN',\n",
       " 'DHI1L_HUMAN',\n",
       " 'SERA_HUMAN',\n",
       " 'BDH_HUMAN',\n",
       " 'HMCS1_HUMAN',\n",
       " 'G6PD_HUMAN',\n",
       " 'RPIA_HUMAN',\n",
       " 'DEOC_HUMAN',\n",
       " 'TKT_HUMAN',\n",
       " '6PGD_HUMAN',\n",
       " 'RPE_HUMAN',\n",
       " 'TALDO_HUMAN',\n",
       " '6PGL_HUMAN',\n",
       " 'ADCY1_HUMAN',\n",
       " 'ADCY4_HUMAN',\n",
       " 'KAD1_HUMAN',\n",
       " 'KAD2_HUMAN',\n",
       " 'KAD9_HUMAN',\n",
       " 'KAD3_HUMAN',\n",
       " 'KAD4_HUMAN',\n",
       " '5NTD_HUMAN',\n",
       " 'ADK_HUMAN',\n",
       " 'DCK_HUMAN',\n",
       " 'PUR9_HUMAN',\n",
       " 'IMDH2_HUMAN',\n",
       " 'IMDH1_HUMAN',\n",
       " 'PURA1_HUMAN',\n",
       " 'PURA2_HUMAN',\n",
       " 'GUAA_HUMAN',\n",
       " 'APT_HUMAN',\n",
       " 'ITPA_HUMAN',\n",
       " 'PUR1_HUMAN',\n",
       " 'PUR8_HUMAN',\n",
       " 'HPRT_HUMAN',\n",
       " 'ACOX3_HUMAN',\n",
       " 'ACADV_HUMAN',\n",
       " 'GUAD_HUMAN',\n",
       " 'PNPH_HUMAN',\n",
       " 'THIO_HUMAN',\n",
       " 'RIR1_HUMAN',\n",
       " 'PUR2_HUMAN',\n",
       " 'PUR6_HUMAN',\n",
       " 'PUR4_HUMAN',\n",
       " 'UCK2_HUMAN',\n",
       " 'PRDX6_HUMAN',\n",
       " 'NUDT5_HUMAN',\n",
       " 'NDKB_HUMAN',\n",
       " 'NDKA_HUMAN',\n",
       " 'TRXR1_HUMAN',\n",
       " 'KCY_HUMAN',\n",
       " 'PYRG1_HUMAN',\n",
       " 'PYR1_HUMAN',\n",
       " 'UMPS_HUMAN',\n",
       " 'DPYL2_HUMAN',\n",
       " 'DPYL3_HUMAN',\n",
       " 'CDD_HUMAN',\n",
       " 'UPP1_HUMAN',\n",
       " 'PYRD_HUMAN',\n",
       " 'KTHY_HUMAN',\n",
       " 'DUT_HUMAN',\n",
       " 'KITH_HUMAN',\n",
       " 'DNM1L_HUMAN',\n",
       " 'EF1A2_HUMAN',\n",
       " 'EF1A1_HUMAN',\n",
       " 'EFTU_HUMAN',\n",
       " 'EF2_HUMAN',\n",
       " 'EFGM_HUMAN',\n",
       " 'DYN2_HUMAN',\n",
       " 'PAPS1_HUMAN',\n",
       " 'DCTD_HUMAN',\n",
       " 'DCTP1_HUMAN',\n",
       " 'POLI_HUMAN',\n",
       " 'POLK_HUMAN',\n",
       " 'REV3L_HUMAN',\n",
       " 'MBB1A_HUMAN',\n",
       " 'DPOE4_HUMAN',\n",
       " 'RFC5_HUMAN',\n",
       " 'DPOE1_HUMAN',\n",
       " 'RPA1_HUMAN',\n",
       " 'PAPOA_HUMAN',\n",
       " 'PAPOB_HUMAN',\n",
       " 'RPC2_HUMAN',\n",
       " 'TUT4_HUMAN',\n",
       " 'RPAC1_HUMAN',\n",
       " 'DHE3_HUMAN',\n",
       " 'ASSY_HUMAN',\n",
       " 'ARLY_HUMAN',\n",
       " 'AATM_HUMAN',\n",
       " 'AATC_HUMAN',\n",
       " 'FUMH_HUMAN',\n",
       " 'GSHR_HUMAN',\n",
       " 'CPSM_HUMAN',\n",
       " 'GLSK_HUMAN',\n",
       " 'ASNS_HUMAN',\n",
       " 'NIT2_HUMAN',\n",
       " 'DCE1_HUMAN',\n",
       " 'PLPHP_HUMAN',\n",
       " 'OAT_HUMAN',\n",
       " 'ARGI2_HUMAN',\n",
       " 'P5CR2_HUMAN',\n",
       " 'P5CR3_HUMAN',\n",
       " 'P5CR1_HUMAN',\n",
       " 'P5CS_HUMAN',\n",
       " 'SPEE_HUMAN',\n",
       " 'SPSY_HUMAN',\n",
       " 'CNDP2_HUMAN',\n",
       " 'P4HA1_HUMAN',\n",
       " 'P4HA2_HUMAN',\n",
       " 'MTAP_HUMAN',\n",
       " 'KCRM_HUMAN',\n",
       " 'KCRB_HUMAN',\n",
       " 'SERC_HUMAN',\n",
       " 'HYI_HUMAN',\n",
       " 'GLYM_HUMAN',\n",
       " 'GGT1_HUMAN',\n",
       " 'NAA10_HUMAN',\n",
       " 'NAA11_HUMAN',\n",
       " 'NAA15_HUMAN',\n",
       " 'ODO2_HUMAN',\n",
       " 'ODO1_HUMAN',\n",
       " 'SMYD3_HUMAN',\n",
       " 'SUV91_HUMAN',\n",
       " 'SC11A_HUMAN',\n",
       " 'PLOD2_HUMAN',\n",
       " 'PLOD3_HUMAN',\n",
       " 'PLOD1_HUMAN',\n",
       " 'GT251_HUMAN',\n",
       " 'ECHM_HUMAN',\n",
       " 'ECHA_HUMAN',\n",
       " 'HCDH_HUMAN',\n",
       " 'HCD2_HUMAN',\n",
       " 'THIL_HUMAN',\n",
       " 'DUOX2_HUMAN',\n",
       " 'THIM_HUMAN',\n",
       " 'ECHB_HUMAN',\n",
       " 'BCAT1_HUMAN',\n",
       " '3HIDH_HUMAN',\n",
       " 'MCCB_HUMAN',\n",
       " 'ANM5_HUMAN',\n",
       " 'FBLL1_HUMAN',\n",
       " 'FBRL_HUMAN',\n",
       " 'NEP1_HUMAN',\n",
       " 'NOP2_HUMAN',\n",
       " 'ANM8_HUMAN',\n",
       " 'TM10C_HUMAN',\n",
       " 'SPB1_HUMAN',\n",
       " 'NSUN5_HUMAN',\n",
       " 'CARM1_HUMAN',\n",
       " 'NSUN4_HUMAN',\n",
       " 'ANM1_HUMAN',\n",
       " 'COMT_HUMAN',\n",
       " 'GSTK1_HUMAN',\n",
       " 'GSTP1_HUMAN',\n",
       " 'MGST1_HUMAN',\n",
       " 'GSTO1_HUMAN',\n",
       " 'GSTM3_HUMAN',\n",
       " 'GSTM5_HUMAN',\n",
       " 'GSTM1_HUMAN',\n",
       " 'MIF_HUMAN',\n",
       " 'OXLA_HUMAN',\n",
       " 'FAAA_HUMAN',\n",
       " 'HS2ST_HUMAN',\n",
       " 'MAT2B_HUMAN',\n",
       " 'METK2_HUMAN',\n",
       " 'SAHH_HUMAN',\n",
       " 'SAHH3_HUMAN',\n",
       " 'SAHH2_HUMAN',\n",
       " 'CBSL_HUMAN',\n",
       " 'PON2_HUMAN',\n",
       " 'DNM3A_HUMAN',\n",
       " 'DNM3B_HUMAN',\n",
       " 'MDHC_HUMAN',\n",
       " 'MDHM_HUMAN',\n",
       " 'OPLA_HUMAN',\n",
       " 'ESTD_HUMAN',\n",
       " 'PRDX1_HUMAN',\n",
       " 'PRDX3_HUMAN',\n",
       " 'PRDX5_HUMAN',\n",
       " 'GPX4_HUMAN',\n",
       " 'GPX1_HUMAN',\n",
       " 'PRDX2_HUMAN',\n",
       " 'GSH0_HUMAN',\n",
       " 'GSHB_HUMAN',\n",
       " 'PSA_HUMAN',\n",
       " 'AMPL_HUMAN',\n",
       " 'SYMM_HUMAN',\n",
       " 'SYMC_HUMAN',\n",
       " 'UAP1_HUMAN',\n",
       " 'GNPI1_HUMAN',\n",
       " 'GFPT2_HUMAN',\n",
       " 'GFPT1_HUMAN',\n",
       " 'SIAS_HUMAN',\n",
       " 'NEUA_HUMAN',\n",
       " 'AGM1_HUMAN',\n",
       " 'SYYC_HUMAN',\n",
       " 'SYAC_HUMAN',\n",
       " 'SYRC_HUMAN',\n",
       " 'SYNC_HUMAN',\n",
       " 'SYDC_HUMAN',\n",
       " 'SYCC_HUMAN',\n",
       " 'SYQ_HUMAN',\n",
       " 'SYEP_HUMAN',\n",
       " 'GARS_HUMAN',\n",
       " 'SYIC_HUMAN',\n",
       " 'SYLC_HUMAN',\n",
       " 'SYK_HUMAN',\n",
       " 'SYFA_HUMAN',\n",
       " 'SYFB_HUMAN',\n",
       " 'SYSC_HUMAN',\n",
       " 'SYTC_HUMAN',\n",
       " 'SYWC_HUMAN',\n",
       " 'SYVC_HUMAN',\n",
       " 'GALT2_HUMAN',\n",
       " 'GLTL5_HUMAN',\n",
       " 'FPPS_HUMAN',\n",
       " 'DPM1_HUMAN',\n",
       " 'DPM3_HUMAN',\n",
       " 'DAD1_HUMAN',\n",
       " 'OST48_HUMAN',\n",
       " 'RPN1_HUMAN',\n",
       " 'RPN2_HUMAN',\n",
       " 'STT3B_HUMAN',\n",
       " 'STT3A_HUMAN',\n",
       " 'MOGS_HUMAN',\n",
       " 'GANAB_HUMAN',\n",
       " 'MGAT3_HUMAN',\n",
       " 'MGT5A_HUMAN',\n",
       " 'PPGB_HUMAN',\n",
       " 'FUCO_HUMAN',\n",
       " 'ALBU_HUMAN',\n",
       " 'TFR1_HUMAN',\n",
       " 'EPHA2_HUMAN',\n",
       " 'ERBB3_HUMAN',\n",
       " 'FGFR1_HUMAN',\n",
       " 'FGFR3_HUMAN',\n",
       " 'FGFR4_HUMAN',\n",
       " 'LCK_HUMAN',\n",
       " 'LYN_HUMAN',\n",
       " 'MP2K1_HUMAN',\n",
       " 'TIE2_HUMAN',\n",
       " 'MP2K3_HUMAN',\n",
       " 'MP2K4_HUMAN',\n",
       " 'FGR_HUMAN',\n",
       " 'BLK_HUMAN',\n",
       " 'CSK_HUMAN',\n",
       " 'HCK_HUMAN',\n",
       " 'FGFR2_HUMAN',\n",
       " 'FER_HUMAN',\n",
       " 'EPHA4_HUMAN',\n",
       " 'MP2K7_HUMAN',\n",
       " 'FYN_HUMAN',\n",
       " 'YES_HUMAN',\n",
       " 'PTPC1_HUMAN',\n",
       " 'PTPRB_HUMAN',\n",
       " 'DUS3_HUMAN',\n",
       " 'PTN13_HUMAN',\n",
       " 'PTPRS_HUMAN',\n",
       " 'PTN1_HUMAN',\n",
       " 'PPAC_HUMAN',\n",
       " 'DUS22_HUMAN',\n",
       " 'TPST2_HUMAN',\n",
       " 'CATD_HUMAN',\n",
       " 'CATL1_HUMAN',\n",
       " 'CATB_HUMAN',\n",
       " 'CATZ_HUMAN',\n",
       " 'CATC_HUMAN',\n",
       " 'CAH3_HUMAN',\n",
       " 'ULA1_HUMAN',\n",
       " 'CAH9_HUMAN',\n",
       " 'CAH2_HUMAN',\n",
       " 'BPNT1_HUMAN',\n",
       " 'SUCA_HUMAN',\n",
       " 'SUCB1_HUMAN',\n",
       " 'SUCB2_HUMAN',\n",
       " 'IDHP_HUMAN',\n",
       " 'IDHC_HUMAN',\n",
       " 'SCOT1_HUMAN',\n",
       " 'IDH3B_HUMAN',\n",
       " 'IDH3A_HUMAN',\n",
       " 'CISY_HUMAN',\n",
       " 'ACLY_HUMAN',\n",
       " 'ACOC_HUMAN',\n",
       " 'ACON_HUMAN',\n",
       " 'SDHA_HUMAN',\n",
       " 'SDHB_HUMAN',\n",
       " 'IPYR_HUMAN',\n",
       " 'IPYR2_HUMAN',\n",
       " 'ETFB_HUMAN',\n",
       " 'ETFA_HUMAN',\n",
       " 'COX2_HUMAN',\n",
       " 'COX5B_HUMAN',\n",
       " 'COX41_HUMAN',\n",
       " 'COX6C_HUMAN',\n",
       " 'CX6B1_HUMAN',\n",
       " 'ATP5H_HUMAN',\n",
       " 'ATP5I_HUMAN',\n",
       " 'ATP5L_HUMAN',\n",
       " 'ATPA_HUMAN',\n",
       " 'ATPG_HUMAN',\n",
       " 'ATP5J_HUMAN',\n",
       " 'AT5F1_HUMAN',\n",
       " 'ATPB_HUMAN',\n",
       " 'ATPO_HUMAN',\n",
       " 'ATPD_HUMAN',\n",
       " 'QCR1_HUMAN',\n",
       " 'QCR2_HUMAN',\n",
       " 'QCR7_HUMAN',\n",
       " 'UCRI_HUMAN',\n",
       " 'CY1_HUMAN',\n",
       " 'NDUB7_HUMAN',\n",
       " 'NDUBB_HUMAN',\n",
       " 'NDUC2_HUMAN',\n",
       " 'NDUS3_HUMAN',\n",
       " 'NDUV2_HUMAN',\n",
       " 'NDUS1_HUMAN',\n",
       " 'NDUBA_HUMAN',\n",
       " 'SODC_HUMAN',\n",
       " 'SODM_HUMAN',\n",
       " 'ACBG1_HUMAN',\n",
       " 'ACSL4_HUMAN',\n",
       " 'ACSL3_HUMAN',\n",
       " 'FAS_HUMAN',\n",
       " 'ACACB_HUMAN',\n",
       " 'DHB12_HUMAN',\n",
       " 'HACD3_HUMAN',\n",
       " 'BACH_HUMAN',\n",
       " 'PGH2_HUMAN',\n",
       " 'PGH1_HUMAN',\n",
       " 'CP19A_HUMAN',\n",
       " 'HYEP_HUMAN',\n",
       " 'ECI1_HUMAN',\n",
       " 'ECI2_HUMAN',\n",
       " 'DHB4_HUMAN',\n",
       " 'CBR1_HUMAN',\n",
       " 'DHRS4_HUMAN',\n",
       " 'LKHA4_HUMAN',\n",
       " 'CP4FN_HUMAN',\n",
       " 'TBCB_HUMAN',\n",
       " 'PGES2_HUMAN',\n",
       " 'TEBP_HUMAN',\n",
       " 'DECR_HUMAN',\n",
       " 'ECH1_HUMAN',\n",
       " 'ACSF2_HUMAN',\n",
       " 'PTGR1_HUMAN',\n",
       " 'AMPB_HUMAN',\n",
       " 'NAT10_HUMAN',\n",
       " 'MBOA1_HUMAN',\n",
       " 'PCAT1_HUMAN',\n",
       " 'ACOT9_HUMAN',\n",
       " 'SDC1_HUMAN',\n",
       " 'GPDM_HUMAN',\n",
       " 'FACE1_HUMAN',\n",
       " 'PCYOX_HUMAN',\n",
       " 'NQO1_HUMAN',\n",
       " 'IDI1_HUMAN',\n",
       " 'FDFT_HUMAN',\n",
       " 'CP51A_HUMAN',\n",
       " 'LBR_HUMAN',\n",
       " 'NSDHL_HUMAN',\n",
       " 'DHCR7_HUMAN',\n",
       " 'ASAH1_HUMAN',\n",
       " 'LPIN2_HUMAN',\n",
       " 'UGGG1_HUMAN',\n",
       " 'NSMA2_HUMAN',\n",
       " 'PLD3_HUMAN',\n",
       " 'PLPL7_HUMAN',\n",
       " 'LYPA1_HUMAN',\n",
       " 'PCY2_HUMAN',\n",
       " 'PA1B2_HUMAN',\n",
       " 'PA1B3_HUMAN',\n",
       " 'LIS1_HUMAN',\n",
       " 'GNT2A_HUMAN',\n",
       " 'FHL2_HUMAN',\n",
       " 'TBL1R_HUMAN',\n",
       " 'ANKR1_HUMAN',\n",
       " 'TIAM2_HUMAN',\n",
       " 'PLIN2_HUMAN',\n",
       " 'APOA1_HUMAN',\n",
       " 'CBX1_HUMAN',\n",
       " 'XYLT2_HUMAN',\n",
       " 'XYLT1_HUMAN',\n",
       " 'CHSTC_HUMAN',\n",
       " 'GNS_HUMAN',\n",
       " 'EST3_HUMAN',\n",
       " 'BAP31_HUMAN',\n",
       " 'SSRD_HUMAN',\n",
       " 'CDO1_HUMAN',\n",
       " 'NB5R3_HUMAN',\n",
       " 'NB5R1_HUMAN',\n",
       " 'NADC_HUMAN',\n",
       " 'PNCB_HUMAN',\n",
       " 'NAMPT_HUMAN',\n",
       " 'NNMT_HUMAN',\n",
       " 'PANK2_HUMAN',\n",
       " 'PANK1_HUMAN',\n",
       " 'PPCS_HUMAN',\n",
       " 'PLCG2_HUMAN',\n",
       " 'INO1_HUMAN',\n",
       " 'IMPA1_HUMAN',\n",
       " 'PK3C3_HUMAN',\n",
       " 'PHP14_HUMAN',\n",
       " 'P4K2A_HUMAN',\n",
       " 'OCRL_HUMAN',\n",
       " 'SYNJ2_HUMAN',\n",
       " 'I5P2_HUMAN',\n",
       " 'PK3CA_HUMAN',\n",
       " 'PK3CG_HUMAN',\n",
       " 'DHPR_HUMAN',\n",
       " 'C1TC_HUMAN',\n",
       " 'MTDC_HUMAN',\n",
       " 'C1TM_HUMAN',\n",
       " 'SPRE_HUMAN',\n",
       " 'PHS_HUMAN',\n",
       " 'GLRX1_HUMAN',\n",
       " 'FRDA_HUMAN',\n",
       " 'FRIH_HUMAN',\n",
       " 'HPS3_HUMAN',\n",
       " 'HEM3_HUMAN',\n",
       " 'DCUP_HUMAN',\n",
       " 'HEM6_HUMAN',\n",
       " 'HMOX1_HUMAN',\n",
       " 'BIEA_HUMAN',\n",
       " 'BLVRB_HUMAN',\n",
       " 'RET1_HUMAN',\n",
       " 'NTPCR_HUMAN',\n",
       " 'PDXK_HUMAN',\n",
       " 'VTDB_HUMAN',\n",
       " '4EBP3_HUMAN',\n",
       " 'THOP1_HUMAN',\n",
       " 'CN37_HUMAN',\n",
       " 'AP4A_HUMAN',\n",
       " 'ZCCHV_HUMAN',\n",
       " 'PARP1_HUMAN',\n",
       " 'CALM3_HUMAN',\n",
       " 'UBP5_HUMAN',\n",
       " 'UBP14_HUMAN',\n",
       " 'UBP34_HUMAN',\n",
       " 'UBP44_HUMAN',\n",
       " 'USP9X_HUMAN',\n",
       " 'UBP25_HUMAN',\n",
       " 'U17L2_HUMAN',\n",
       " 'UBP10_HUMAN',\n",
       " 'UBP24_HUMAN',\n",
       " 'UBP11_HUMAN',\n",
       " 'GOLI_HUMAN',\n",
       " 'HECW1_HUMAN',\n",
       " 'SAE1_HUMAN',\n",
       " 'SAE2_HUMAN',\n",
       " 'UB2L3_HUMAN',\n",
       " 'UBA1_HUMAN',\n",
       " 'UBA7_HUMAN',\n",
       " 'UBC12_HUMAN',\n",
       " 'UBE2K_HUMAN',\n",
       " 'UHRF1_HUMAN',\n",
       " 'HUWE1_HUMAN',\n",
       " 'TRIPC_HUMAN',\n",
       " 'TRI18_HUMAN',\n",
       " 'UBA6_HUMAN',\n",
       " 'UB2D2_HUMAN',\n",
       " 'UB2D3_HUMAN',\n",
       " 'UB2D4_HUMAN',\n",
       " 'UBE2C_HUMAN',\n",
       " 'CHIP_HUMAN',\n",
       " 'FKBP6_HUMAN',\n",
       " 'FKB1A_HUMAN',\n",
       " 'FKB11_HUMAN',\n",
       " 'FKBP3_HUMAN',\n",
       " 'FKBP4_HUMAN',\n",
       " 'FKBP9_HUMAN',\n",
       " 'PPIA_HUMAN',\n",
       " 'PPIC_HUMAN',\n",
       " 'PIN4_HUMAN',\n",
       " 'FKB10_HUMAN',\n",
       " 'PPIB_HUMAN',\n",
       " 'PPIF_HUMAN',\n",
       " 'FKBP5_HUMAN',\n",
       " 'PPID_HUMAN',\n",
       " 'PPWD1_HUMAN',\n",
       " 'FKBP8_HUMAN',\n",
       " 'PPIH_HUMAN',\n",
       " 'MYLK2_HUMAN',\n",
       " 'MYLK3_HUMAN',\n",
       " 'MYLK4_HUMAN',\n",
       " 'MYLK_HUMAN',\n",
       " 'CDY1_HUMAN',\n",
       " 'HAT1_HUMAN',\n",
       " 'TF3C4_HUMAN',\n",
       " 'KAT6A_HUMAN',\n",
       " 'TGM2_HUMAN',\n",
       " 'PIMT_HUMAN',\n",
       " 'NCPR_HUMAN',\n",
       " 'TPMT_HUMAN',\n",
       " 'MCE1_HUMAN',\n",
       " 'NMT1_HUMAN',\n",
       " 'DDAH2_HUMAN',\n",
       " 'DDAH1_HUMAN',\n",
       " 'ASPH_HUMAN',\n",
       " 'ANXA3_HUMAN',\n",
       " 'NQO2_HUMAN',\n",
       " 'MTRR_HUMAN',\n",
       " 'PGP_HUMAN',\n",
       " 'AAKG2_HUMAN',\n",
       " 'AKT2_HUMAN',\n",
       " 'ARAF_HUMAN',\n",
       " 'CDK1_HUMAN',\n",
       " 'CDK12_HUMAN',\n",
       " 'CDK14_HUMAN',\n",
       " 'CDK16_HUMAN',\n",
       " 'CDKL3_HUMAN',\n",
       " 'CSK2B_HUMAN',\n",
       " 'GLU2B_HUMAN',\n",
       " 'KAP0_HUMAN',\n",
       " 'M3K1_HUMAN',\n",
       " 'M3K13_HUMAN',\n",
       " 'MINK1_HUMAN',\n",
       " 'MK03_HUMAN',\n",
       " 'PAK2_HUMAN',\n",
       " 'PAK1_HUMAN',\n",
       " 'PLK2_HUMAN',\n",
       " 'SMG1_HUMAN',\n",
       " 'NEK8_HUMAN',\n",
       " 'STK24_HUMAN',\n",
       " 'TAF1_HUMAN',\n",
       " 'MK09_HUMAN',\n",
       " 'MK10_HUMAN',\n",
       " 'MK11_HUMAN',\n",
       " 'CDK3_HUMAN',\n",
       " 'E2AK2_HUMAN',\n",
       " 'AKT1_HUMAN',\n",
       " 'OXSR1_HUMAN',\n",
       " 'STK39_HUMAN',\n",
       " 'CDK13_HUMAN',\n",
       " 'MK01_HUMAN',\n",
       " 'CDK5_HUMAN',\n",
       " 'E2AK4_HUMAN',\n",
       " 'ATR_HUMAN',\n",
       " 'MAPK2_HUMAN',\n",
       " 'CSK22_HUMAN',\n",
       " 'MK14_HUMAN',\n",
       " 'KAP2_HUMAN',\n",
       " 'CSK21_HUMAN',\n",
       " 'AKT3_HUMAN',\n",
       " 'M4K2_HUMAN',\n",
       " 'MK12_HUMAN',\n",
       " 'CDK18_HUMAN',\n",
       " 'M3K4_HUMAN',\n",
       " 'KS6B1_HUMAN',\n",
       " 'MK08_HUMAN',\n",
       " 'MAST4_HUMAN',\n",
       " 'KC1A_HUMAN',\n",
       " 'AURKB_HUMAN',\n",
       " 'M3K15_HUMAN',\n",
       " 'TLK1_HUMAN',\n",
       " 'PLK3_HUMAN',\n",
       " 'CDK17_HUMAN',\n",
       " 'STK26_HUMAN',\n",
       " 'PRKDC_HUMAN',\n",
       " 'CDK9_HUMAN',\n",
       " 'KPCT_HUMAN',\n",
       " 'KS6B2_HUMAN',\n",
       " '2AAA_HUMAN',\n",
       " '2AAB_HUMAN',\n",
       " 'PGAM5_HUMAN',\n",
       " 'PP1A_HUMAN',\n",
       " 'PP2AB_HUMAN',\n",
       " 'PP2AA_HUMAN',\n",
       " 'PPP5_HUMAN',\n",
       " 'PPE1_HUMAN',\n",
       " 'PP1B_HUMAN',\n",
       " 'PP4C_HUMAN',\n",
       " 'PPM1G_HUMAN',\n",
       " 'PDIA1_HUMAN',\n",
       " 'PDIA5_HUMAN',\n",
       " 'PDIA6_HUMAN',\n",
       " 'PDIA4_HUMAN',\n",
       " 'PDIA3_HUMAN',\n",
       " 'FABP5_HUMAN',\n",
       " 'MOT1_HUMAN',\n",
       " 'MOT4_HUMAN',\n",
       " 'GTR1_HUMAN',\n",
       " 'NPT2B_HUMAN',\n",
       " '4F2_HUMAN',\n",
       " 'CTL2_HUMAN',\n",
       " 'LAT1_HUMAN',\n",
       " 'AT1A3_HUMAN',\n",
       " 'AT1B1_HUMAN',\n",
       " 'AT1B3_HUMAN',\n",
       " 'AT1A1_HUMAN',\n",
       " 'AT1A2_HUMAN',\n",
       " 'AAAT_HUMAN',\n",
       " 'S38A2_HUMAN',\n",
       " 'SLC31_HUMAN',\n",
       " 'CELR3_HUMAN',\n",
       " 'B3A3_HUMAN',\n",
       " 'B3AT_HUMAN',\n",
       " 'AT2A1_HUMAN',\n",
       " 'AT2A3_HUMAN',\n",
       " 'AT2B3_HUMAN',\n",
       " 'AT2B4_HUMAN',\n",
       " 'AT2A2_HUMAN',\n",
       " 'AT2B1_HUMAN',\n",
       " 'AT12A_HUMAN',\n",
       " 'ATP4A_HUMAN',\n",
       " 'COPA_HUMAN',\n",
       " 'COPB_HUMAN',\n",
       " 'COPB2_HUMAN',\n",
       " 'COPE_HUMAN',\n",
       " 'COPG1_HUMAN',\n",
       " 'COPD_HUMAN',\n",
       " 'ACBP_HUMAN',\n",
       " 'CMC2_HUMAN',\n",
       " 'DIC_HUMAN',\n",
       " 'M2OM_HUMAN',\n",
       " 'TXTP_HUMAN',\n",
       " 'MPCP_HUMAN',\n",
       " 'SFXN1_HUMAN',\n",
       " 'ADT1_HUMAN',\n",
       " 'ADT2_HUMAN',\n",
       " 'NU153_HUMAN',\n",
       " 'NU214_HUMAN',\n",
       " 'NUP50_HUMAN',\n",
       " 'NU155_HUMAN',\n",
       " 'NUP93_HUMAN',\n",
       " 'PO210_HUMAN',\n",
       " 'NUP54_HUMAN',\n",
       " 'RBP2_HUMAN',\n",
       " 'SEC13_HUMAN',\n",
       " 'RAE1L_HUMAN',\n",
       " 'TPR_HUMAN',\n",
       " 'VIGLN_HUMAN',\n",
       " 'IMA7_HUMAN',\n",
       " 'XPO7_HUMAN',\n",
       " 'VAPB_HUMAN',\n",
       " 'VAPA_HUMAN',\n",
       " 'PLIN3_HUMAN',\n",
       " 'VATA_HUMAN',\n",
       " 'VATB2_HUMAN',\n",
       " 'VATG2_HUMAN',\n",
       " 'VATC1_HUMAN',\n",
       " 'VATG1_HUMAN',\n",
       " 'PEPD_HUMAN',\n",
       " 'ABCA4_HUMAN',\n",
       " 'AT11C_HUMAN',\n",
       " 'ACO13_HUMAN',\n",
       " 'SAP_HUMAN']"
      ]
     },
     "execution_count": 287,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "#Print overlap.\n",
    "final_overlap"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 288,
   "id": "proof-crazy",
   "metadata": {
    "scrolled": true
   },
   "outputs": [
    {
     "data": {
      "text/html": [
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       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>UniprotID</th>\n",
       "      <th>ReactionID</th>\n",
       "      <th>ReactionRule</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>HOT_HUMAN ADH1G_HUMAN ADHX_HUMAN PTGR3_HUMAN A...</td>\n",
       "      <td>HMR_3905</td>\n",
       "      <td>Q8IWW8 or P28332 or Q8N4Q0 or P07327 or P40394...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>AK1A1_HUMAN</td>\n",
       "      <td>HMR_3907</td>\n",
       "      <td>P14550</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>ACSA_HUMAN</td>\n",
       "      <td>HMR_4097</td>\n",
       "      <td>Q9NR19</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>ACS2L_HUMAN ACSS3_HUMAN</td>\n",
       "      <td>HMR_4099</td>\n",
       "      <td>Q9H6R3 or Q9NUB1</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>ACSA_HUMAN</td>\n",
       "      <td>HMR_4108</td>\n",
       "      <td>Q9NR19</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>...</th>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>13082</th>\n",
       "      <td>NTCP_HUMAN</td>\n",
       "      <td>HMR_10119</td>\n",
       "      <td>Q14973</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>13083</th>\n",
       "      <td>NTCP_HUMAN</td>\n",
       "      <td>HMR_10120</td>\n",
       "      <td>Q14973</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>13088</th>\n",
       "      <td>MRP3_HUMAN ABCBB_HUMAN</td>\n",
       "      <td>HMR_10125</td>\n",
       "      <td>O95342 or O15438</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>13089</th>\n",
       "      <td>MRP3_HUMAN ABCBB_HUMAN</td>\n",
       "      <td>HMR_10126</td>\n",
       "      <td>O95342 or O15438</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>13090</th>\n",
       "      <td>NTCP_HUMAN</td>\n",
       "      <td>HMR_10127</td>\n",
       "      <td>Q14973</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>8036 rows × 3 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "                                               UniprotID ReactionID  \\\n",
       "0      HOT_HUMAN ADH1G_HUMAN ADHX_HUMAN PTGR3_HUMAN A...   HMR_3905   \n",
       "1                                            AK1A1_HUMAN   HMR_3907   \n",
       "2                                             ACSA_HUMAN   HMR_4097   \n",
       "3                                ACS2L_HUMAN ACSS3_HUMAN   HMR_4099   \n",
       "4                                             ACSA_HUMAN   HMR_4108   \n",
       "...                                                  ...        ...   \n",
       "13082                                         NTCP_HUMAN  HMR_10119   \n",
       "13083                                         NTCP_HUMAN  HMR_10120   \n",
       "13088                             MRP3_HUMAN ABCBB_HUMAN  HMR_10125   \n",
       "13089                             MRP3_HUMAN ABCBB_HUMAN  HMR_10126   \n",
       "13090                                         NTCP_HUMAN  HMR_10127   \n",
       "\n",
       "                                            ReactionRule  \n",
       "0      Q8IWW8 or P28332 or Q8N4Q0 or P07327 or P40394...  \n",
       "1                                                 P14550  \n",
       "2                                                 Q9NR19  \n",
       "3                                       Q9H6R3 or Q9NUB1  \n",
       "4                                                 Q9NR19  \n",
       "...                                                  ...  \n",
       "13082                                             Q14973  \n",
       "13083                                             Q14973  \n",
       "13088                                   O95342 or O15438  \n",
       "13089                                   O95342 or O15438  \n",
       "13090                                             Q14973  \n",
       "\n",
       "[8036 rows x 3 columns]"
      ]
     },
     "execution_count": 288,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "#Creating new variable for model for next stage of the analysis.\n",
    "model = Updated_model\n",
    "model"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 289,
   "id": "available-absorption",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
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       "    .dataframe tbody tr th:only-of-type {\n",
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       "\n",
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       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>0</th>\n",
       "      <th>1</th>\n",
       "      <th>2</th>\n",
       "      <th>3</th>\n",
       "      <th>4</th>\n",
       "      <th>5</th>\n",
       "      <th>6</th>\n",
       "      <th>7</th>\n",
       "      <th>8</th>\n",
       "      <th>9</th>\n",
       "      <th>...</th>\n",
       "      <th>341</th>\n",
       "      <th>342</th>\n",
       "      <th>343</th>\n",
       "      <th>344</th>\n",
       "      <th>345</th>\n",
       "      <th>346</th>\n",
       "      <th>347</th>\n",
       "      <th>348</th>\n",
       "      <th>349</th>\n",
       "      <th>350</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>HOT_HUMAN</td>\n",
       "      <td>ADH1G_HUMAN</td>\n",
       "      <td>ADHX_HUMAN</td>\n",
       "      <td>PTGR3_HUMAN</td>\n",
       "      <td>ADH1B_HUMAN</td>\n",
       "      <td>ADH1A_HUMAN</td>\n",
       "      <td>ADH6_HUMAN</td>\n",
       "      <td>ADH7_HUMAN</td>\n",
       "      <td>ADH4_HUMAN</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>AK1A1_HUMAN</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>ACSA_HUMAN</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>ACS2L_HUMAN</td>\n",
       "      <td>ACSS3_HUMAN</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>ACSA_HUMAN</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>...</th>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>13082</th>\n",
       "      <td>NTCP_HUMAN</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>13083</th>\n",
       "      <td>NTCP_HUMAN</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>13088</th>\n",
       "      <td>MRP3_HUMAN</td>\n",
       "      <td>ABCBB_HUMAN</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>13089</th>\n",
       "      <td>MRP3_HUMAN</td>\n",
       "      <td>ABCBB_HUMAN</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>13090</th>\n",
       "      <td>NTCP_HUMAN</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>8036 rows × 351 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "               0            1           2            3            4    \\\n",
       "0        HOT_HUMAN  ADH1G_HUMAN  ADHX_HUMAN  PTGR3_HUMAN  ADH1B_HUMAN   \n",
       "1      AK1A1_HUMAN         None        None         None         None   \n",
       "2       ACSA_HUMAN         None        None         None         None   \n",
       "3      ACS2L_HUMAN  ACSS3_HUMAN        None         None         None   \n",
       "4       ACSA_HUMAN         None        None         None         None   \n",
       "...            ...          ...         ...          ...          ...   \n",
       "13082   NTCP_HUMAN         None        None         None         None   \n",
       "13083   NTCP_HUMAN         None        None         None         None   \n",
       "13088   MRP3_HUMAN  ABCBB_HUMAN        None         None         None   \n",
       "13089   MRP3_HUMAN  ABCBB_HUMAN        None         None         None   \n",
       "13090   NTCP_HUMAN         None        None         None         None   \n",
       "\n",
       "               5           6           7           8     9    ...   341   342  \\\n",
       "0      ADH1A_HUMAN  ADH6_HUMAN  ADH7_HUMAN  ADH4_HUMAN  None  ...  None  None   \n",
       "1             None        None        None        None  None  ...  None  None   \n",
       "2             None        None        None        None  None  ...  None  None   \n",
       "3             None        None        None        None  None  ...  None  None   \n",
       "4             None        None        None        None  None  ...  None  None   \n",
       "...            ...         ...         ...         ...   ...  ...   ...   ...   \n",
       "13082         None        None        None        None  None  ...  None  None   \n",
       "13083         None        None        None        None  None  ...  None  None   \n",
       "13088         None        None        None        None  None  ...  None  None   \n",
       "13089         None        None        None        None  None  ...  None  None   \n",
       "13090         None        None        None        None  None  ...  None  None   \n",
       "\n",
       "        343   344   345   346   347   348   349   350  \n",
       "0      None  None  None  None  None  None  None  None  \n",
       "1      None  None  None  None  None  None  None  None  \n",
       "2      None  None  None  None  None  None  None  None  \n",
       "3      None  None  None  None  None  None  None  None  \n",
       "4      None  None  None  None  None  None  None  None  \n",
       "...     ...   ...   ...   ...   ...   ...   ...   ...  \n",
       "13082  None  None  None  None  None  None  None  None  \n",
       "13083  None  None  None  None  None  None  None  None  \n",
       "13088  None  None  None  None  None  None  None  None  \n",
       "13089  None  None  None  None  None  None  None  None  \n",
       "13090  None  None  None  None  None  None  None  None  \n",
       "\n",
       "[8036 rows x 351 columns]"
      ]
     },
     "execution_count": 289,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "#Split UniprotID into one protein name per column, and one reaction per row.\n",
    "separated_ids = model.UniprotID.str.split(expand=True,)\n",
    "separated_ids"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 96,
   "id": "suffering-framing",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "0        HOT_HUMAN\n",
       "1      ADH1G_HUMAN\n",
       "2       ADHX_HUMAN\n",
       "3      PTGR3_HUMAN\n",
       "4      ADH1B_HUMAN\n",
       "          ...     \n",
       "346           None\n",
       "347           None\n",
       "348           None\n",
       "349           None\n",
       "350           None\n",
       "Name: 0, Length: 351, dtype: object"
      ]
     },
     "execution_count": 96,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "#Checking how to access each reaction. \n",
    "separated_ids.iloc[0,:] #e.g. first row"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 119,
   "id": "direct-boulder",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "['HMR_3905',\n",
       " 'HMR_3907',\n",
       " 'HMR_4097',\n",
       " 'HMR_4099',\n",
       " 'HMR_4108',\n",
       " 'HMR_4133',\n",
       " 'HMR_4137',\n",
       " 'HMR_4281',\n",
       " 'HMR_4388',\n",
       " 'HMR_4283',\n",
       " 'HMR_8357',\n",
       " 'HMR_4379',\n",
       " 'HMR_4301',\n",
       " 'HMR_4355',\n",
       " 'HMR_4358',\n",
       " 'HMR_4360',\n",
       " 'HMR_4363',\n",
       " 'HMR_4365',\n",
       " 'HMR_4368',\n",
       " 'HMR_4370',\n",
       " 'HMR_4371',\n",
       " 'HMR_4372',\n",
       " 'HMR_4373',\n",
       " 'HMR_4375',\n",
       " 'HMR_4377',\n",
       " 'HMR_4381',\n",
       " 'HMR_4391',\n",
       " 'HMR_4394',\n",
       " 'HMR_4396',\n",
       " 'HMR_4521',\n",
       " 'HMR_6410',\n",
       " 'HMR_6412',\n",
       " 'HMR_7745',\n",
       " 'HMR_7746',\n",
       " 'HMR_7747',\n",
       " 'HMR_7748',\n",
       " 'HMR_7749',\n",
       " 'HMR_8360',\n",
       " 'HMR_8652',\n",
       " 'HMR_8757',\n",
       " 'HMR_3989',\n",
       " 'HMR_4122',\n",
       " 'HMR_4837',\n",
       " 'HMR_5395',\n",
       " 'HMR_5396',\n",
       " 'HMR_9727',\n",
       " 'HMR_5397',\n",
       " 'HMR_5398',\n",
       " 'HMR_5399',\n",
       " 'HMR_5400',\n",
       " 'HMR_5401',\n",
       " 'HMR_8568',\n",
       " 'HMR_8569',\n",
       " 'HMR_8570',\n",
       " 'HMR_8571',\n",
       " 'HMR_8572',\n",
       " 'HMR_8573',\n",
       " 'HMR_8574',\n",
       " 'HMR_8575',\n",
       " 'HMR_8576',\n",
       " 'HMR_8577',\n",
       " 'HMR_8578',\n",
       " 'HMR_8579',\n",
       " 'HMR_8581',\n",
       " 'HMR_8591',\n",
       " 'HMR_8592',\n",
       " 'HMR_8580',\n",
       " 'HMR_8582',\n",
       " 'HMR_8587',\n",
       " 'HMR_8589',\n",
       " 'HMR_8583',\n",
       " 'HMR_8584',\n",
       " 'HMR_8585',\n",
       " 'HMR_3944',\n",
       " 'HMR_4128',\n",
       " 'HMR_4130',\n",
       " 'HMR_4131',\n",
       " 'HMR_4132',\n",
       " 'HMR_4303',\n",
       " 'HMR_4414',\n",
       " 'HMR_4415',\n",
       " 'HMR_4416',\n",
       " 'HMR_4774',\n",
       " 'HMR_4775',\n",
       " 'HMR_4832',\n",
       " 'HMR_7674',\n",
       " 'HMR_8761',\n",
       " 'HMR_8762',\n",
       " 'HMR_8764',\n",
       " 'HMR_8766',\n",
       " 'HMR_8767',\n",
       " 'HMR_4297',\n",
       " 'HMR_4310',\n",
       " 'HMR_4315',\n",
       " 'HMR_4316',\n",
       " 'HMR_4317',\n",
       " 'HMR_4318',\n",
       " 'HMR_4319',\n",
       " 'HMR_4320',\n",
       " 'HMR_4356',\n",
       " 'HMR_4383',\n",
       " 'HMR_4385',\n",
       " 'HMR_4386',\n",
       " 'HMR_4387',\n",
       " 'HMR_4399',\n",
       " 'HMR_4400',\n",
       " 'HMR_4401',\n",
       " 'HMR_4402',\n",
       " 'HMR_4490',\n",
       " 'HMR_4706',\n",
       " 'HMR_8768',\n",
       " 'HMR_4590',\n",
       " 'HMR_4591',\n",
       " 'HMR_4592',\n",
       " 'HMR_4593',\n",
       " 'HMR_4594',\n",
       " 'HMR_4595',\n",
       " 'HMR_8341',\n",
       " 'HMR_8344',\n",
       " 'HMR_8352',\n",
       " 'HMR_8726',\n",
       " 'HMR_8727',\n",
       " 'HMR_8729',\n",
       " 'HMR_6537',\n",
       " 'HMR_1568',\n",
       " 'HMR_3853',\n",
       " 'HMR_3854',\n",
       " 'HMR_3855',\n",
       " 'HMR_3857',\n",
       " 'HMR_3859',\n",
       " 'HMR_4087',\n",
       " 'HMR_4089',\n",
       " 'HMR_4091',\n",
       " 'HMR_4093',\n",
       " 'HMR_4095',\n",
       " 'HMR_4101',\n",
       " 'HMR_4103',\n",
       " 'HMR_4143',\n",
       " 'HMR_4193',\n",
       " 'HMR_8497',\n",
       " 'HMR_8498',\n",
       " 'HMR_8499',\n",
       " 'HMR_8500',\n",
       " 'HMR_8501',\n",
       " 'HMR_8502',\n",
       " 'HMR_8503',\n",
       " 'HMR_8504',\n",
       " 'HMR_8506',\n",
       " 'HMR_8507',\n",
       " 'HMR_8508',\n",
       " 'HMR_8509',\n",
       " 'HMR_8511',\n",
       " 'HMR_8512',\n",
       " 'HMR_8514',\n",
       " 'HMR_8516',\n",
       " 'HMR_4280',\n",
       " 'HMR_0153',\n",
       " 'HMR_3212',\n",
       " 'HMR_3797',\n",
       " 'HMR_3800',\n",
       " 'HMR_4105',\n",
       " 'HMR_4106',\n",
       " 'HMR_4107',\n",
       " 'HMR_4282',\n",
       " 'HMR_4331',\n",
       " 'HMR_4459',\n",
       " 'HMR_4460',\n",
       " 'HMR_4497',\n",
       " 'HMR_4741',\n",
       " 'HMR_9804',\n",
       " 'HMR_0718',\n",
       " 'HMR_0719',\n",
       " 'HMR_1434',\n",
       " 'HMR_1436',\n",
       " 'HMR_3163',\n",
       " 'HMR_4461',\n",
       " 'HMR_4604',\n",
       " 'HMR_5351',\n",
       " 'HMR_7709',\n",
       " 'HMR_4052',\n",
       " 'HMR_4304',\n",
       " 'HMR_4306',\n",
       " 'HMR_4350',\n",
       " 'HMR_4351',\n",
       " 'HMR_4352',\n",
       " 'HMR_4354',\n",
       " 'HMR_4398',\n",
       " 'HMR_4404',\n",
       " 'HMR_4473',\n",
       " 'HMR_4474',\n",
       " 'HMR_4476',\n",
       " 'HMR_4477',\n",
       " 'HMR_4501',\n",
       " 'HMR_4565',\n",
       " 'HMR_4567',\n",
       " 'HMR_4568',\n",
       " 'HMR_9799',\n",
       " 'HMR_9800',\n",
       " 'HMR_4623',\n",
       " 'HMR_4625',\n",
       " 'HMR_4710',\n",
       " 'HMR_4841',\n",
       " 'HMR_8074',\n",
       " 'HMR_8653',\n",
       " 'HMR_3998',\n",
       " 'HMR_4000',\n",
       " 'HMR_4002',\n",
       " 'HMR_4004',\n",
       " 'HMR_4010',\n",
       " 'HMR_4081',\n",
       " 'HMR_4082',\n",
       " 'HMR_4012',\n",
       " 'HMR_4014',\n",
       " 'HMR_4020',\n",
       " 'HMR_4022',\n",
       " 'HMR_4038',\n",
       " 'HMR_4040',\n",
       " 'HMR_4042',\n",
       " 'HMR_4046',\n",
       " 'HMR_4048',\n",
       " 'HMR_4080',\n",
       " 'HMR_4085',\n",
       " 'HMR_4086',\n",
       " 'HMR_4134',\n",
       " 'HMR_4135',\n",
       " 'HMR_4168',\n",
       " 'HMR_4171',\n",
       " 'HMR_4290',\n",
       " 'HMR_4406',\n",
       " 'HMR_4412',\n",
       " 'HMR_4417',\n",
       " 'HMR_4418',\n",
       " 'HMR_4419',\n",
       " 'HMR_4421',\n",
       " 'HMR_4449',\n",
       " 'HMR_4450',\n",
       " 'HMR_4452',\n",
       " 'HMR_4453',\n",
       " 'HMR_4480',\n",
       " 'HMR_4481',\n",
       " 'HMR_4482',\n",
       " 'HMR_4486',\n",
       " 'HMR_4487',\n",
       " 'HMR_4488',\n",
       " 'HMR_4489',\n",
       " 'HMR_4492',\n",
       " 'HMR_4493',\n",
       " 'HMR_4495',\n",
       " 'HMR_4496',\n",
       " 'HMR_4518',\n",
       " 'HMR_4519',\n",
       " 'HMR_4520',\n",
       " 'HMR_4573',\n",
       " 'HMR_4574',\n",
       " 'HMR_4600',\n",
       " 'HMR_4602',\n",
       " 'HMR_4603',\n",
       " 'HMR_4611',\n",
       " 'HMR_4612',\n",
       " 'HMR_4614',\n",
       " 'HMR_4615',\n",
       " 'HMR_4617',\n",
       " 'HMR_4618',\n",
       " 'HMR_4619',\n",
       " 'HMR_4621',\n",
       " 'HMR_4632',\n",
       " 'HMR_4646',\n",
       " 'HMR_4648',\n",
       " 'HMR_4649',\n",
       " 'HMR_4650',\n",
       " 'HMR_4651',\n",
       " 'HMR_4663',\n",
       " 'HMR_4664',\n",
       " 'HMR_4694',\n",
       " 'HMR_4695',\n",
       " 'HMR_4705',\n",
       " 'HMR_4709',\n",
       " 'HMR_4799',\n",
       " 'HMR_4802',\n",
       " 'HMR_4804',\n",
       " 'HMR_4808',\n",
       " 'HMR_4810',\n",
       " 'HMR_4812',\n",
       " 'HMR_4814',\n",
       " 'HMR_5301',\n",
       " 'HMR_5353',\n",
       " 'HMR_6601',\n",
       " 'HMR_6602',\n",
       " 'HMR_6603',\n",
       " 'HMR_7144',\n",
       " 'HMR_8755',\n",
       " 'HMR_4016',\n",
       " 'HMR_4018',\n",
       " 'HMR_4044',\n",
       " 'HMR_4291',\n",
       " 'HMR_4420',\n",
       " 'HMR_4570',\n",
       " 'HMR_4572',\n",
       " 'HMR_4006',\n",
       " 'HMR_4028',\n",
       " 'HMR_4030',\n",
       " 'HMR_4670',\n",
       " 'HMR_4673',\n",
       " 'HMR_4675',\n",
       " 'HMR_6614',\n",
       " 'HMR_6615',\n",
       " 'HMR_6616',\n",
       " 'HMR_4635',\n",
       " 'HMR_3793',\n",
       " 'HMR_3931',\n",
       " 'HMR_3969',\n",
       " 'HMR_3970',\n",
       " 'HMR_4008',\n",
       " 'HMR_4032',\n",
       " 'HMR_4034',\n",
       " 'HMR_4036',\n",
       " 'HMR_4050',\n",
       " 'HMR_4056',\n",
       " 'HMR_4059',\n",
       " 'HMR_4060',\n",
       " 'HMR_4127',\n",
       " 'HMR_4177',\n",
       " 'HMR_4179',\n",
       " 'HMR_4182',\n",
       " 'HMR_4183',\n",
       " 'HMR_4192',\n",
       " 'HMR_4194',\n",
       " 'HMR_4210',\n",
       " 'HMR_4211',\n",
       " 'HMR_4343',\n",
       " 'HMR_4345',\n",
       " 'HMR_4346',\n",
       " 'HMR_4470',\n",
       " 'HMR_4471',\n",
       " 'HMR_4472',\n",
       " 'HMR_4484',\n",
       " 'HMR_4485',\n",
       " 'HMR_4510',\n",
       " 'HMR_4512',\n",
       " 'HMR_4513',\n",
       " 'HMR_4514',\n",
       " 'HMR_4577',\n",
       " 'HMR_4579',\n",
       " 'HMR_4580',\n",
       " 'HMR_4608',\n",
       " 'HMR_4575',\n",
       " 'HMR_4637',\n",
       " 'HMR_4642',\n",
       " 'HMR_4643',\n",
       " 'HMR_4644',\n",
       " 'HMR_4676',\n",
       " 'HMR_4736',\n",
       " 'HMR_4819',\n",
       " 'HMR_5299',\n",
       " 'HMR_5352',\n",
       " 'HMR_5415',\n",
       " 'HMR_5416',\n",
       " 'HMR_5417',\n",
       " 'HMR_6612',\n",
       " 'HMR_6613',\n",
       " 'HMR_6621',\n",
       " 'HMR_6622',\n",
       " 'HMR_6623',\n",
       " 'HMR_6624',\n",
       " 'HMR_6627',\n",
       " 'HMR_7744',\n",
       " 'HMR_3965',\n",
       " 'HMR_3966',\n",
       " 'HMR_3967',\n",
       " 'HMR_3968',\n",
       " 'HMR_3999',\n",
       " 'HMR_4024',\n",
       " 'HMR_4026',\n",
       " 'HMR_4054',\n",
       " 'HMR_4061',\n",
       " 'HMR_4083',\n",
       " 'HMR_4136',\n",
       " 'HMR_4180',\n",
       " 'HMR_4185',\n",
       " 'HMR_4186',\n",
       " 'HMR_4342',\n",
       " 'HMR_4483',\n",
       " 'HMR_4507',\n",
       " 'HMR_4516',\n",
       " 'HMR_4601',\n",
       " 'HMR_4633',\n",
       " 'HMR_4640',\n",
       " 'HMR_4641',\n",
       " 'HMR_4680',\n",
       " 'HMR_4806',\n",
       " 'HMR_6625',\n",
       " 'HMR_6626',\n",
       " 'HMR_7160',\n",
       " 'HMR_7161',\n",
       " 'HMR_7162',\n",
       " 'HMR_7163',\n",
       " 'HMR_7164',\n",
       " 'HMR_7713',\n",
       " 'HMR_7716',\n",
       " 'HMR_7717',\n",
       " 'HMR_7721',\n",
       " 'HMR_7725',\n",
       " 'HMR_7728',\n",
       " 'HMR_7800',\n",
       " 'HMR_7801',\n",
       " 'HMR_7802',\n",
       " 'HMR_7863',\n",
       " 'HMR_7864',\n",
       " 'HMR_7865',\n",
       " 'HMR_7866',\n",
       " 'HMR_7867',\n",
       " 'HMR_7868',\n",
       " 'HMR_7869',\n",
       " 'HMR_7870',\n",
       " 'HMR_7871',\n",
       " 'HMR_7872',\n",
       " 'HMR_7873',\n",
       " 'HMR_7874',\n",
       " 'HMR_7875',\n",
       " 'HMR_7876',\n",
       " 'HMR_7878',\n",
       " 'HMR_7879',\n",
       " 'HMR_7880',\n",
       " 'HMR_7881',\n",
       " 'HMR_7882',\n",
       " 'HMR_7883',\n",
       " 'HMR_7884',\n",
       " 'HMR_7885',\n",
       " 'HMR_7886',\n",
       " 'HMR_7887',\n",
       " 'HMR_7888',\n",
       " 'HMR_7889',\n",
       " 'HMR_7890',\n",
       " 'HMR_7891',\n",
       " 'HMR_7892',\n",
       " 'HMR_7893',\n",
       " 'HMR_7894',\n",
       " 'HMR_7895',\n",
       " 'HMR_8083',\n",
       " 'HMR_8085',\n",
       " 'HMR_8087',\n",
       " 'HMR_8443',\n",
       " 'HMR_8444',\n",
       " 'HMR_8445',\n",
       " 'HMR_8446',\n",
       " 'HMR_8448',\n",
       " 'HMR_8449',\n",
       " 'HMR_8450',\n",
       " 'HMR_8451',\n",
       " 'HMR_8452',\n",
       " 'HMR_8453',\n",
       " 'HMR_8454',\n",
       " 'HMR_8455',\n",
       " 'HMR_8456',\n",
       " 'HMR_8457',\n",
       " 'HMR_8458',\n",
       " 'HMR_8459',\n",
       " 'HMR_8460',\n",
       " 'HMR_8461',\n",
       " 'HMR_8462',\n",
       " 'HMR_8463',\n",
       " 'HMR_8464',\n",
       " 'HMR_8465',\n",
       " 'HMR_8466',\n",
       " 'HMR_8467',\n",
       " 'HMR_8468',\n",
       " 'HMR_8469',\n",
       " 'HMR_8470',\n",
       " 'HMR_8471',\n",
       " 'HMR_8472',\n",
       " 'HMR_8473',\n",
       " 'HMR_8474',\n",
       " 'HMR_8477',\n",
       " 'HMR_8478',\n",
       " 'HMR_8479',\n",
       " 'HMR_8480',\n",
       " 'HMR_8482',\n",
       " 'HMR_8483',\n",
       " 'HMR_8485',\n",
       " 'HMR_8486',\n",
       " 'HMR_8487',\n",
       " 'HMR_8488',\n",
       " 'HMR_8489',\n",
       " 'HMR_8493',\n",
       " 'HMR_8494',\n",
       " 'HMR_8495',\n",
       " 'HMR_3802',\n",
       " 'HMR_3804',\n",
       " 'HMR_3811',\n",
       " 'HMR_3813',\n",
       " 'HMR_3822',\n",
       " 'HMR_3827',\n",
       " 'HMR_3829',\n",
       " 'HMR_3831',\n",
       " 'HMR_3862',\n",
       " 'HMR_3865',\n",
       " 'HMR_3870',\n",
       " 'HMR_3873',\n",
       " 'HMR_8654',\n",
       " 'HMR_3890',\n",
       " 'HMR_3892',\n",
       " 'HMR_9802',\n",
       " 'HMR_3899',\n",
       " 'HMR_3903',\n",
       " 'HMR_4109',\n",
       " 'HMR_4114',\n",
       " 'HMR_4115',\n",
       " 'HMR_4118',\n",
       " 'HMR_4172',\n",
       " 'HMR_4196',\n",
       " 'HMR_4197',\n",
       " 'HMR_4287',\n",
       " 'HMR_4690',\n",
       " 'HMR_4693',\n",
       " 'HMR_6780',\n",
       " 'HMR_6968',\n",
       " 'HMR_6969',\n",
       " 'HMR_6970',\n",
       " 'HMR_6971',\n",
       " 'HMR_6972',\n",
       " 'HMR_7641',\n",
       " 'HMR_7642',\n",
       " 'HMR_8626',\n",
       " 'HMR_8628',\n",
       " 'HMR_3806',\n",
       " 'HMR_3807',\n",
       " 'HMR_3809',\n",
       " 'HMR_3816',\n",
       " 'HMR_3819',\n",
       " 'HMR_3820',\n",
       " 'HMR_3833',\n",
       " 'HMR_3835',\n",
       " 'HMR_3837',\n",
       " 'HMR_3838',\n",
       " 'HMR_3895',\n",
       " 'HMR_3897',\n",
       " 'HMR_3956',\n",
       " 'HMR_3993',\n",
       " 'HMR_4073',\n",
       " 'HMR_4075',\n",
       " 'HMR_4077',\n",
       " 'HMR_4190',\n",
       " 'HMR_4191',\n",
       " 'HMR_4212',\n",
       " 'HMR_4422',\n",
       " 'HMR_4423',\n",
       " 'HMR_4424',\n",
       " 'HMR_4583',\n",
       " 'HMR_4605',\n",
       " 'HMR_4606',\n",
       " 'HMR_4607',\n",
       " 'HMR_4776',\n",
       " 'HMR_4777',\n",
       " 'HMR_4778',\n",
       " 'HMR_4779',\n",
       " 'HMR_4780',\n",
       " 'HMR_4781',\n",
       " 'HMR_4784',\n",
       " 'HMR_4785',\n",
       " 'HMR_4786',\n",
       " 'HMR_4787',\n",
       " 'HMR_5384',\n",
       " 'HMR_6929',\n",
       " 'HMR_6930',\n",
       " 'HMR_6931',\n",
       " 'HMR_6932',\n",
       " 'HMR_6933',\n",
       " 'HMR_6934',\n",
       " 'HMR_6935',\n",
       " 'HMR_6936',\n",
       " 'HMR_6938',\n",
       " 'HMR_6939',\n",
       " 'HMR_6941',\n",
       " 'HMR_6942',\n",
       " 'HMR_6943',\n",
       " 'HMR_6944',\n",
       " 'HMR_6945',\n",
       " 'HMR_6946',\n",
       " 'HMR_6947',\n",
       " 'HMR_6948',\n",
       " 'HMR_6949',\n",
       " 'HMR_6950',\n",
       " 'HMR_6951',\n",
       " 'HMR_6952',\n",
       " 'HMR_6953',\n",
       " 'HMR_6954',\n",
       " 'HMR_6958',\n",
       " 'HMR_6959',\n",
       " 'HMR_6961',\n",
       " 'HMR_6962',\n",
       " 'HMR_6963',\n",
       " 'HMR_6964',\n",
       " 'HMR_6965',\n",
       " 'HMR_6966',\n",
       " 'HMR_6967',\n",
       " 'HMR_6973',\n",
       " 'HMR_8096',\n",
       " 'HMR_8097',\n",
       " 'HMR_8098',\n",
       " 'HMR_8416',\n",
       " 'HMR_8425',\n",
       " 'HMR_8426',\n",
       " 'HMR_8427',\n",
       " 'HMR_8432',\n",
       " 'HMR_8603',\n",
       " 'HMR_8604',\n",
       " 'HMR_8605',\n",
       " 'HMR_8606',\n",
       " 'HMR_8608',\n",
       " 'HMR_8609',\n",
       " 'HMR_8610',\n",
       " 'HMR_8611',\n",
       " 'HMR_4285',\n",
       " 'HMR_0457',\n",
       " 'HMR_0460',\n",
       " 'HMR_3750',\n",
       " 'HMR_3752',\n",
       " 'HMR_3770',\n",
       " 'HMR_3771',\n",
       " 'HMR_3772',\n",
       " 'HMR_3782',\n",
       " 'HMR_3784',\n",
       " 'HMR_3794',\n",
       " 'HMR_3839',\n",
       " 'HMR_3841',\n",
       " 'HMR_3843',\n",
       " 'HMR_3845',\n",
       " 'HMR_3847',\n",
       " 'HMR_3849',\n",
       " 'HMR_3852',\n",
       " 'HMR_3856',\n",
       " 'HMR_3883',\n",
       " 'HMR_3901',\n",
       " 'HMR_3939',\n",
       " 'HMR_3974',\n",
       " 'HMR_4198',\n",
       " 'HMR_4199',\n",
       " 'HMR_4200',\n",
       " 'HMR_4348',\n",
       " 'HMR_4466',\n",
       " 'HMR_4467',\n",
       " 'HMR_4582',\n",
       " 'HMR_4584',\n",
       " 'HMR_4696',\n",
       " 'HMR_4697',\n",
       " 'HMR_4698',\n",
       " 'HMR_4699',\n",
       " 'HMR_4700',\n",
       " 'HMR_4742',\n",
       " 'HMR_4788',\n",
       " 'HMR_4789',\n",
       " 'HMR_4791',\n",
       " 'HMR_4792',\n",
       " 'HMR_4937',\n",
       " 'HMR_5392',\n",
       " 'HMR_5393',\n",
       " 'HMR_6409',\n",
       " 'HMR_7702',\n",
       " 'HMR_7703',\n",
       " 'HMR_8433',\n",
       " 'HMR_8434',\n",
       " 'HMR_8435',\n",
       " 'HMR_8436',\n",
       " 'HMR_8437',\n",
       " 'HMR_8439',\n",
       " 'HMR_8440',\n",
       " 'HMR_8441',\n",
       " 'HMR_9486',\n",
       " 'HMR_4426',\n",
       " 'HMR_4428',\n",
       " 'HMR_4429',\n",
       " 'HMR_4430',\n",
       " 'HMR_4431',\n",
       " 'HMR_4437',\n",
       " 'HMR_4658',\n",
       " 'HMR_4660',\n",
       " 'HMR_4712',\n",
       " 'HMR_5336',\n",
       " 'HMR_5337',\n",
       " 'HMR_5338',\n",
       " 'HMR_5339',\n",
       " 'HMR_5340',\n",
       " 'HMR_8783',\n",
       " 'HMR_8784',\n",
       " 'HMR_8786',\n",
       " 'HMR_4239',\n",
       " 'HMR_4241',\n",
       " 'HMR_4288',\n",
       " 'HMR_4596',\n",
       " 'HMR_4597',\n",
       " 'HMR_4599',\n",
       " 'HMR_4667',\n",
       " 'HMR_4668',\n",
       " 'HMR_4737',\n",
       " 'HMR_4739',\n",
       " 'HMR_4740',\n",
       " 'HMR_6415',\n",
       " 'HMR_6975',\n",
       " 'HMR_6976',\n",
       " 'HMR_6977',\n",
       " 'HMR_6978',\n",
       " 'HMR_6979',\n",
       " 'HMR_6980',\n",
       " 'HMR_6981',\n",
       " 'HMR_6982',\n",
       " 'HMR_6983',\n",
       " 'HMR_6984',\n",
       " 'HMR_6985',\n",
       " 'HMR_8021',\n",
       " 'HMR_8025',\n",
       " 'HMR_8026',\n",
       " 'HMR_8027',\n",
       " 'HMR_8029',\n",
       " 'HMR_3164',\n",
       " 'HMR_3166',\n",
       " 'HMR_3885',\n",
       " 'HMR_8091',\n",
       " 'HMR_8092',\n",
       " 'HMR_8563',\n",
       " 'HMR_8564',\n",
       " 'HMR_8566',\n",
       " 'HMR_3935',\n",
       " 'HMR_4681',\n",
       " 'HMR_4682',\n",
       " 'HMR_4683',\n",
       " 'HMR_4685',\n",
       " 'HMR_4686',\n",
       " 'HMR_4687',\n",
       " 'HMR_4703',\n",
       " 'HMR_4704',\n",
       " 'HMR_6988',\n",
       " 'HMR_7689',\n",
       " 'HMR_7701',\n",
       " 'HMR_8094',\n",
       " 'HMR_8529',\n",
       " 'HMR_8530',\n",
       " 'HMR_8533',\n",
       " 'HMR_8534',\n",
       " 'HMR_8535',\n",
       " 'HMR_8537',\n",
       " 'HMR_8541',\n",
       " 'HMR_8542',\n",
       " 'HMR_8543',\n",
       " 'HMR_8544',\n",
       " 'HMR_8630',\n",
       " 'HMR_9734',\n",
       " 'HMR_3206',\n",
       " 'HMR_3208',\n",
       " 'HMR_3211',\n",
       " 'HMR_3213',\n",
       " 'HMR_3215',\n",
       " 'HMR_3747',\n",
       " 'HMR_3744',\n",
       " 'HMR_3757',\n",
       " 'HMR_3761',\n",
       " 'HMR_3777',\n",
       " 'HMR_3778',\n",
       " 'HMR_3795',\n",
       " 'HMR_4797',\n",
       " 'HMR_6417',\n",
       " 'HMR_6419',\n",
       " 'HMR_6420',\n",
       " 'HMR_6421',\n",
       " 'HMR_6422',\n",
       " 'HMR_6923',\n",
       " 'HMR_3765',\n",
       " 'HMR_6924',\n",
       " 'HMR_6925',\n",
       " 'HMR_6926',\n",
       " 'HMR_6927',\n",
       " 'HMR_8088',\n",
       " 'HMR_8787',\n",
       " 'HMR_3743',\n",
       " 'HMR_3940',\n",
       " 'HMR_4214',\n",
       " 'HMR_4216',\n",
       " 'HMR_4218',\n",
       " 'HMR_4219',\n",
       " 'HMR_4220',\n",
       " 'HMR_4222',\n",
       " 'HMR_4224',\n",
       " 'HMR_4225',\n",
       " 'HMR_4227',\n",
       " 'HMR_4231',\n",
       " 'HMR_4242',\n",
       " 'HMR_4243',\n",
       " 'HMR_4244',\n",
       " 'HMR_4246',\n",
       " 'HMR_6707',\n",
       " 'HMR_6710',\n",
       " 'HMR_6711',\n",
       " 'HMR_6713',\n",
       " 'HMR_6714',\n",
       " 'HMR_6715',\n",
       " 'HMR_6716',\n",
       " 'HMR_6717',\n",
       " 'HMR_6718',\n",
       " 'HMR_6719',\n",
       " 'HMR_6722',\n",
       " 'HMR_6723',\n",
       " 'HMR_6725',\n",
       " 'HMR_6726',\n",
       " 'HMR_6727',\n",
       " 'HMR_6728',\n",
       " 'HMR_6729',\n",
       " 'HMR_6730',\n",
       " 'HMR_6731',\n",
       " 'HMR_6735',\n",
       " 'HMR_6736',\n",
       " 'HMR_6737',\n",
       " 'HMR_6739',\n",
       " 'HMR_6740',\n",
       " 'HMR_6741',\n",
       " 'HMR_6743',\n",
       " 'HMR_6745',\n",
       " 'HMR_6746',\n",
       " 'HMR_6747',\n",
       " 'HMR_6748',\n",
       " 'HMR_6749',\n",
       " 'HMR_6750',\n",
       " 'HMR_6751',\n",
       " 'HMR_6752',\n",
       " 'HMR_6753',\n",
       " 'HMR_6754',\n",
       " 'HMR_6755',\n",
       " 'HMR_6756',\n",
       " 'HMR_6757',\n",
       " 'HMR_6758',\n",
       " 'HMR_6760',\n",
       " 'HMR_6761',\n",
       " 'HMR_6762',\n",
       " 'HMR_6763',\n",
       " 'HMR_6764',\n",
       " 'HMR_6766',\n",
       " 'HMR_6767',\n",
       " 'HMR_6768',\n",
       " 'HMR_6770',\n",
       " 'HMR_6771',\n",
       " 'HMR_6772',\n",
       " 'HMR_6774',\n",
       " 'HMR_6776',\n",
       " 'HMR_6778',\n",
       " 'HMR_6787',\n",
       " 'HMR_6788',\n",
       " 'HMR_6789',\n",
       " 'HMR_6790',\n",
       " 'HMR_6791',\n",
       " 'HMR_6798',\n",
       " 'HMR_6799',\n",
       " 'HMR_6800',\n",
       " 'HMR_6801',\n",
       " 'HMR_6803',\n",
       " 'HMR_6808',\n",
       " 'HMR_6811',\n",
       " 'HMR_6813',\n",
       " 'HMR_6814',\n",
       " 'HMR_6815',\n",
       " 'HMR_6817',\n",
       " 'HMR_6819',\n",
       " 'HMR_6820',\n",
       " 'HMR_6823',\n",
       " 'HMR_6824',\n",
       " 'HMR_6826',\n",
       " 'HMR_6827',\n",
       " 'HMR_6828',\n",
       " 'HMR_6829',\n",
       " 'HMR_6830',\n",
       " 'HMR_6831',\n",
       " 'HMR_6834',\n",
       " 'HMR_6835',\n",
       " 'HMR_6836',\n",
       " 'HMR_6837',\n",
       " 'HMR_6838',\n",
       " 'HMR_6839',\n",
       " 'HMR_6840',\n",
       " 'HMR_6841',\n",
       " 'HMR_6842',\n",
       " 'HMR_6843',\n",
       " 'HMR_6844',\n",
       " 'HMR_6845',\n",
       " 'HMR_6848',\n",
       " 'HMR_6849',\n",
       " 'HMR_6850',\n",
       " 'HMR_6851',\n",
       " 'HMR_6854',\n",
       " 'HMR_6855',\n",
       " 'HMR_6874',\n",
       " 'HMR_6883',\n",
       " 'HMR_6885',\n",
       " 'HMR_6886',\n",
       " 'HMR_6888',\n",
       " 'HMR_6889',\n",
       " 'HMR_7628',\n",
       " 'HMR_7756',\n",
       " 'HMR_8539',\n",
       " 'HMR_8796',\n",
       " 'HMR_3875',\n",
       " 'HMR_3877',\n",
       " 'HMR_3879',\n",
       " 'HMR_3881',\n",
       " 'HMR_3912',\n",
       " 'HMR_3917',\n",
       " 'HMR_3919',\n",
       " 'HMR_3920',\n",
       " 'HMR_3922',\n",
       " 'HMR_3928',\n",
       " 'HMR_3995',\n",
       " 'HMR_4072',\n",
       " 'HMR_4189',\n",
       " 'HMR_4302',\n",
       " 'HMR_4323',\n",
       " 'HMR_5381',\n",
       " 'HMR_5385',\n",
       " 'HMR_5386',\n",
       " 'HMR_5387',\n",
       " 'HMR_5388',\n",
       " 'HMR_5389',\n",
       " 'HMR_5390',\n",
       " 'HMR_5391',\n",
       " 'HMR_5418',\n",
       " 'HMR_5419',\n",
       " 'HMR_6515',\n",
       " 'HMR_6518',\n",
       " 'HMR_6519',\n",
       " 'HMR_6520',\n",
       " 'HMR_6523',\n",
       " 'HMR_8062',\n",
       " 'HMR_8066',\n",
       " 'HMR_8067',\n",
       " 'HMR_8068',\n",
       " 'HMR_8069',\n",
       " 'HMR_8641',\n",
       " 'HMR_8683',\n",
       " 'HMR_8684',\n",
       " 'HMR_3868',\n",
       " 'HMR_3869',\n",
       " 'HMR_3889',\n",
       " 'HMR_3933',\n",
       " 'HMR_3937',\n",
       " 'HMR_4116',\n",
       " 'HMR_4120',\n",
       " 'HMR_4121',\n",
       " 'HMR_4175',\n",
       " 'HMR_4176',\n",
       " 'HMR_4324',\n",
       " 'HMR_4326',\n",
       " 'HMR_4328',\n",
       " 'HMR_4329',\n",
       " 'HMR_4708',\n",
       " 'HMR_8769',\n",
       " 'HMR_8770',\n",
       " 'HMR_4078',\n",
       " 'HMR_4079',\n",
       " 'HMR_4174',\n",
       " 'HMR_4330',\n",
       " 'HMR_4347',\n",
       " 'HMR_4425',\n",
       " 'HMR_4427',\n",
       " 'HMR_4688',\n",
       " 'HMR_4689',\n",
       " 'HMR_4735',\n",
       " 'HMR_7992',\n",
       " 'HMR_7993',\n",
       " 'HMR_7128',\n",
       " 'HMR_7129',\n",
       " 'HMR_7131',\n",
       " 'HMR_7132',\n",
       " 'HMR_7133',\n",
       " 'HMR_7134',\n",
       " 'HMR_7135',\n",
       " 'HMR_7136',\n",
       " 'HMR_7137',\n",
       " 'HMR_7138',\n",
       " 'HMR_7139',\n",
       " 'HMR_7141',\n",
       " 'HMR_7620',\n",
       " 'HMR_7647',\n",
       " 'HMR_8640',\n",
       " 'HMR_8689',\n",
       " 'HMR_8690',\n",
       " 'HMR_3748',\n",
       " 'HMR_3751',\n",
       " 'HMR_3753',\n",
       " 'HMR_3755',\n",
       " 'HMR_3759',\n",
       " 'HMR_3763',\n",
       " 'HMR_3767',\n",
       " 'HMR_3769',\n",
       " 'HMR_3773',\n",
       " 'HMR_3775',\n",
       " 'HMR_3780',\n",
       " 'HMR_3783',\n",
       " 'HMR_3785',\n",
       " 'HMR_3790',\n",
       " 'HMR_3792',\n",
       " 'HMR_3796',\n",
       " 'HMR_3823',\n",
       " 'HMR_6416',\n",
       " 'HMR_3986',\n",
       " 'HMR_3988',\n",
       " ...]"
      ]
     },
     "execution_count": 119,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "#Converting ReactionID column into list, to be added to end of separated IDs df.\n",
    "ReactionID = model.ReactionID.tolist()\n",
    "ReactionID"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 120,
   "id": "institutional-hartford",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "['Q8IWW8 or P28332 or Q8N4Q0 or P07327 or P40394 or P00325 or P11766 or P08319 or P00326',\n",
       " 'P14550',\n",
       " 'Q9NR19',\n",
       " 'Q9H6R3 or Q9NUB1',\n",
       " 'Q9NR19',\n",
       " 'Q9NR19',\n",
       " 'P09622 and O00330 and P08559 and P10515 and P29803 and P11177',\n",
       " 'P07195 or P00338 or Q8IX04 or P07864 or Q6ZMR3 or Q9BYZ2',\n",
       " 'P07195 or P00338 or Q8IX04 or P07864 or Q6ZMR3 or Q9BYZ2',\n",
       " 'P43353 or P30838 or P48448 or P47895',\n",
       " 'P51648 or P05091 or P30837 or P49189 or P49419',\n",
       " 'Q01813 or P17858 or P08237',\n",
       " 'Q01813 or P17858 or P08237 or O43822',\n",
       " 'P09972 or P05062 or P04075 or P04075',\n",
       " 'P14618 or Q969K7 or P30613 or Q9P1Z3',\n",
       " 'Q8N4Q0',\n",
       " 'P06733 or P13929 or P09104',\n",
       " 'P15259 or P18669 or P07738 or Q8N0Y7',\n",
       " 'P54108 or P00558 or Q5JRA6 or P07205',\n",
       " 'P07311 or P14621',\n",
       " 'P15259 or P18669 or P07738 or Q8N0Y7',\n",
       " 'P07738',\n",
       " 'O14556 or P04406',\n",
       " 'P09972 or P05062 or P04075 or P04075',\n",
       " 'O00757 or P09467',\n",
       " 'P06744',\n",
       " 'P60174',\n",
       " 'P35557 or Q2TB90 or P19367 or Q9BRR6 or P52789 or P52790',\n",
       " 'P36871 or Q15124 or Q96G03',\n",
       " 'P35575 or Q9BUM1 or Q9NQR9',\n",
       " '( P08559 and P11177 ) or ( P29803 and P11177 )',\n",
       " '( P09622 and P08559 and P10515 and P11177 ) or ( P09622 and P10515 and P29803 and P11177 )',\n",
       " 'Q96C23',\n",
       " 'P35557 or Q2TB90 or P19367 or P52789 or P52790',\n",
       " 'Q9BRR6',\n",
       " 'P06744',\n",
       " 'P06744',\n",
       " 'P04040',\n",
       " 'P35575 or Q9BUM1 or Q9NQR9',\n",
       " 'P05181',\n",
       " 'P20807 or P10253 or Q8TET4 or O43451',\n",
       " 'O60701',\n",
       " 'O43280 or Q32M88',\n",
       " 'O15488 or P46976',\n",
       " 'O15488 or P13807 or P54840 or P46976',\n",
       " 'P13807 or P54840 or Q9UQK1 or Q86XI6',\n",
       " 'Q04446',\n",
       " 'P11217 or P06737 or P11216',\n",
       " 'P35573',\n",
       " 'P35573',\n",
       " 'P11217 or P06737 or P11216',\n",
       " 'Q6UWQ5 or P0DUB6 or P0DUB6 or P0DUB6 or P19961 or P04746',\n",
       " 'Q6UWQ5 or P0DUB6 or P0DUB6 or P0DUB6 or P19961 or P04746',\n",
       " 'Q6UWQ5 or P0DUB6 or P0DUB6 or P0DUB6 or P19961 or P04746',\n",
       " 'Q6UWQ5 or P0DUB6 or P0DUB6 or P0DUB6 or P19961 or P04746',\n",
       " 'Q6UWQ5 or P0DUB6 or P0DUB6 or P0DUB6 or P19961 or P04746',\n",
       " 'Q6UWQ5 or P0DUB6 or P0DUB6 or P0DUB6 or P19961 or P04746',\n",
       " 'Q6UWQ5 or P0DUB6 or P0DUB6 or P0DUB6 or P19961 or P04746',\n",
       " 'Q6UWQ5 or P0DUB6 or P0DUB6 or P0DUB6 or P19961 or P04746',\n",
       " 'Q6UWQ5 or P0DUB6 or P0DUB6 or P0DUB6 or P19961 or P04746',\n",
       " 'Q6UWQ5 or P0DUB6 or P0DUB6 or P0DUB6 or P19961 or P04746',\n",
       " 'Q6UWQ5 or P0DUB6 or P0DUB6 or P0DUB6 or P19961 or P04746',\n",
       " 'Q6UWQ5 or P0DUB6 or P0DUB6 or P0DUB6 or P19961 or P04746',\n",
       " 'Q6UWQ5 or P0DUB6 or P0DUB6 or P0DUB6 or P19961 or P04746',\n",
       " 'Q8TET4 or O43451',\n",
       " 'P10253',\n",
       " 'Q6UWQ5 or P0DUB6 or P0DUB6 or P0DUB6 or P19961 or P04746',\n",
       " 'Q6UWQ5 or P0DUB6 or P0DUB6 or P0DUB6 or P19961 or P04746',\n",
       " 'Q8TET4 or O43451',\n",
       " 'P10253',\n",
       " 'O43451',\n",
       " 'P14410',\n",
       " 'Q6PCE3',\n",
       " 'Q16851',\n",
       " 'Q14376',\n",
       " 'P51570 or Q01415',\n",
       " 'P07902',\n",
       " 'P07902',\n",
       " 'P14410 or P10253 or Q8TET4 or O43451',\n",
       " 'P51570 or Q01415 or Q96M60',\n",
       " 'P09848 and Q6UWU2 and P16278 and Q6ZT21',\n",
       " 'P06280 or P16278 or P83881',\n",
       " 'Q01813 or P17858 or P08237',\n",
       " 'Q01813 or P17858 or P08237',\n",
       " 'P09848 and Q6UWU2 and P16278 and Q6ZT21',\n",
       " 'P15291 or O60909 or P00709',\n",
       " 'P50053',\n",
       " 'P09972 or P05062 or P04075 or P04075',\n",
       " 'P09848',\n",
       " 'P15121 or O60218',\n",
       " 'P07902',\n",
       " 'Q16877 or O60825 or P16118 or Q16875',\n",
       " 'P50053',\n",
       " 'Q00796',\n",
       " 'P15121 or O60218',\n",
       " 'O75063 or Q9HA64 or Q5SY16 or Q9H479 or Q96C11',\n",
       " 'O75063 or Q9HA64 or Q5SY16 or Q9H479 or Q96C11',\n",
       " 'Q2TB90 or P19367 or P52789 or P52790',\n",
       " 'O75063 or Q9HA64 or Q5SY16 or Q9H479 or Q96C11',\n",
       " 'P09972 or P05062 or P04075 or P04075',\n",
       " 'P34949',\n",
       " 'Q9Y535 or Q92871 or O15305',\n",
       " 'Q96IJ6 or Q5XPI4 or Q9Y5P6 or Q86WK7',\n",
       " 'Q96IJ6 or Q9Y5P6 or Q86WK7',\n",
       " 'O60547',\n",
       " 'Q13630',\n",
       " 'Q59H18 or O14772 or Q59H18',\n",
       " 'Q8N0W3',\n",
       " 'Q2TB90 or P19367 or P52789 or P52790',\n",
       " 'Q9NQ88 or Q92988 or Q16877 or O60825 or P16118 or Q16875',\n",
       " 'Q13630',\n",
       " 'Q7Z4W1',\n",
       " 'Q9BY49 or Q9BV79',\n",
       " 'P15121 or O60218',\n",
       " 'Q00796',\n",
       " 'Q9UQ10',\n",
       " 'O75191',\n",
       " 'O43488 or P15121 or P14550',\n",
       " 'P14550',\n",
       " 'Q9Y2S2',\n",
       " 'Q9H477',\n",
       " 'Q9Y673',\n",
       " 'Q8NBZ7',\n",
       " 'P14550',\n",
       " 'P43353 or P30838 or P48448 or P47895',\n",
       " 'Q04760 or Q9HC38',\n",
       " 'P15121 or O60218',\n",
       " 'P15121 or O60218',\n",
       " 'Q16775 or Q6PII5',\n",
       " 'Q86WU2 or Q6P9G0',\n",
       " 'P23368 or Q16798',\n",
       " 'Q9UIY3 or P48163',\n",
       " 'P23368 or Q16798',\n",
       " 'Q8WYK0',\n",
       " 'Q8WYK0',\n",
       " 'P35558',\n",
       " 'Q16822',\n",
       " 'P11498',\n",
       " 'P14618 or P30613',\n",
       " 'O43488 or P15121 or P14550',\n",
       " 'P05181',\n",
       " 'P05181',\n",
       " 'O43488 or P15121 or P14550',\n",
       " 'Q9UBQ7',\n",
       " 'Q8IWW8 or P28332 or P07327 or P40394 or P00325 or P11766 or P08319 or P00326',\n",
       " 'P43353 or P51648 or P30838 or P48448 or P49189 or P49419 or P47895',\n",
       " 'P51648 or P05091 or P30837 or P49189 or P49419',\n",
       " 'P51648 or P05091 or P30837 or P49189 or P49419',\n",
       " 'Q8IWW8 or P28332 or Q8N4Q0 or P07327 or P40394 or P00325 or P11766 or P08319 or P00326',\n",
       " 'Q8IWW8 or P28332 or Q8N4Q0 or P07327 or P40394 or P00325 or P11766 or P08319 or P00326',\n",
       " 'O43488 or P15121 or P14550',\n",
       " 'Q16775 or Q6PII5',\n",
       " 'Q86WU2',\n",
       " 'Q86WU2 or Q6P9G0',\n",
       " 'Q13825',\n",
       " 'P07195 or P00338 or Q8IX04 or P07864 or Q6ZMR3 or Q9BYZ2',\n",
       " 'Q9H6R3 or Q9NR19 or Q9NUB1',\n",
       " 'Q6JQN1 or P11310 or P16219 or Q9UKU7 or Q9H845 or P45954 or Q709F0',\n",
       " 'Q9H6R3 or Q9NR19 or Q9NUB1',\n",
       " 'P21953 and P09622 and P11182 and P12694',\n",
       " 'O95822',\n",
       " 'O95822',\n",
       " 'O95822',\n",
       " 'Q02252',\n",
       " 'Q9H6R3 or Q9NR19 or Q9NUB1',\n",
       " 'Q9H6R3 or Q9NR19 or Q9NUB1',\n",
       " 'Q9H6R3 or Q9NR19 or Q9NUB1',\n",
       " 'Q15392',\n",
       " 'Q6NVY1',\n",
       " 'Q9BPX1 or Q9H2F3 or Q13268 or Q9BUP3 or Q8IZV5 or Q5I0G3 or Q96NR8 or Q8N4T8 or Q13363 or Q8NBN7 or Q9BUT1 or Q7Z5J1 or Q8NEX9 or Q8N3Y7 or P80365 or A6NKP2 or Q8WUS8 or Q9NZC7 or Q04828 or P11766 or O60218 or Q8NBQ5 or P17516 or Q92506 or C9JRZ8 or Q9HBH5',\n",
       " 'Q9H9P8',\n",
       " 'O43175',\n",
       " 'Q9BWD1',\n",
       " 'Q86V21',\n",
       " 'Q6JQN1 or P11310 or P16219 or Q9UKU7 or Q9H845 or P45954 or Q709F0',\n",
       " 'Q02338 or Q9BUT1',\n",
       " 'Q01581',\n",
       " 'P07195 or Q8IX04 or P07864 or Q6ZMR3 or Q9BYZ2',\n",
       " 'Q86YB7',\n",
       " 'P11908 or P60891 or P21108',\n",
       " 'P11413',\n",
       " 'P11413',\n",
       " 'Q9NXR7 or Q9H477',\n",
       " 'P49247',\n",
       " 'P49247',\n",
       " 'P36871 or Q96G03',\n",
       " 'Q9Y315',\n",
       " 'P51854 or Q9H0I9 or P29401',\n",
       " 'P52209',\n",
       " 'P52209',\n",
       " 'P21673 or Q96F10',\n",
       " 'Q96AT9 or Q2QD12',\n",
       " 'P51854 or Q9H0I9 or P29401',\n",
       " 'P37837',\n",
       " 'Q01813 or P17858 or P08237',\n",
       " 'Q01813 or P17858 or P08237',\n",
       " 'Q9UHJ6',\n",
       " 'P50053',\n",
       " 'O95479 or O95336',\n",
       " 'O95479 or O95336',\n",
       " 'Q96G03 or Q9HBF5',\n",
       " 'P43353 or P30838 or P48448 or P47895',\n",
       " 'Q9NXR7 or Q9H477',\n",
       " 'O95479 or O95336',\n",
       " 'Q9Y5L3 or P49961 or O75355 or Q8WVQ1 or O75356 or Q5MY95 or Q9Y227 or O75354',\n",
       " '( Q02153 and Q02108 ) or P25092 or Q08462 or P51841 or P51828 or Q8NFM4 or Q02846 or O60266 or Q96PN6 or P33402 or P40145 or P20594 or O60503 or Q08828 or P16066 or O95622 or O43306',\n",
       " 'P54819 or Q9Y3D8 or P00568 or Q96M32 or Q9UIJ7 or Q9Y6K8 or Q5TCS8 or P27144 or Q96MA6 or Q16594',\n",
       " 'P54819 or Q9Y3D8 or P00568 or Q96M32 or Q9UIJ7 or Q9Y6K8 or Q5TCS8 or P27144 or Q96MA6 or Q16594',\n",
       " 'P15309 or P49902 or Q9BXI3 or Q9H0P0 or Q8TCD5 or P21589 or Q969T7 or Q9NYW8 or Q96P26 or Q9NPB1 or C9J2C7',\n",
       " 'P15309 or P49902 or Q9BXI3 or Q9H0P0 or Q8TCD5 or P21589 or Q969T7 or Q9NYW8 or Q96P26 or Q9NPB1 or C9J2C7',\n",
       " 'P15309 or P49902 or Q9BXI3 or Q9H0P0 or Q8TCD5 or P21589 or Q969T7 or Q9NYW8 or Q96P26 or Q9NPB1 or C9J2C7',\n",
       " 'P55263 or P27707',\n",
       " 'P27815 or O60658 or P51160 or Q08493 or Q9Y233 or O95263 or Q08499 or P54750 or Q01064 or Q9HCR9 or P16499 or P35913 or O95998 or O76074 or Q13956 or Q13370 or Q14123 or O43924 or O76083 or Q9NP56 or Q14432 or Q07343 or P18545 or O00408 or Q13946',\n",
       " 'Q16774',\n",
       " '( Q02153 and Q02108 ) or P25092 or Q08462 or P51841 or P51828 or Q8NFM4 or Q02846 or O60266 or Q96PN6 or P33402 or P40145 or P20594 or O60503 or Q08828 or P16066 or O95622 or O43306',\n",
       " 'P31939',\n",
       " 'P20839 or P12268',\n",
       " 'P30520 or Q8N142',\n",
       " 'P49915',\n",
       " 'P27815 or O60658 or P51160 or Q08493 or Q9Y233 or O95263 or Q08499 or P54750 or Q01064 or Q9HCR9 or P16499 or P35913 or O95998 or O76074 or Q13956 or Q13370 or Q14123 or O43924 or O76083 or Q9NP56 or Q14432 or Q07343 or P18545 or O00408 or Q13946',\n",
       " 'Q01433 or P23109 or Q01432',\n",
       " 'P07741',\n",
       " 'P07741',\n",
       " 'Q9Y5L3 or P49961 or O75355 or Q8WVQ1 or O75356 or Q5MY95 or Q9Y227 or O75354',\n",
       " 'Q16774',\n",
       " 'Q9BY32',\n",
       " 'P14618 or P30613',\n",
       " 'P49961 or O75355 or Q5MY95',\n",
       " 'Q06203',\n",
       " 'Q9UPQ9 or P30566',\n",
       " 'P15309 or P49902 or Q9BXI3 or Q9H0P0 or Q8TCD5 or P21589 or Q969T7 or Q9NYW8 or Q96P26 or Q9NPB1 or C9J2C7',\n",
       " 'P00492',\n",
       " 'Q9P2T1 or P36959',\n",
       " 'P14618 or P30613',\n",
       " 'P15309 or P49902 or Q9BXI3 or Q9H0P0 or Q8TCD5 or P21589 or Q969T7 or Q9NYW8 or Q96P26 or Q9NPB1 or C9J2C7',\n",
       " 'P15309 or P49902 or Q9BXI3 or Q9H0P0 or Q8TCD5 or P21589 or Q969T7 or Q9NYW8 or Q96P26 or Q9NPB1 or C9J2C7',\n",
       " 'P00492',\n",
       " 'P49915',\n",
       " 'P54819 or P49748 or Q9Y3D8 or O15254 or P00568 or P11310 or Q96M32 or Q9UIJ7 or Q9UKU7 or Q9Y6K8 or Q5TCS8 or P27144 or Q96MA6 or Q9H845',\n",
       " 'Q9NZK5 or P00813',\n",
       " 'Q9NZK5 or P00813',\n",
       " 'Q2TB90 or P19367 or P52789 or P52790',\n",
       " 'Q2TB90 or P19367 or P52789 or P52790',\n",
       " 'Q2TB90 or P19367 or P52789 or P52790',\n",
       " 'Q2TB90 or P19367 or P52789 or P52790',\n",
       " 'Q2TB90 or P19367 or P52789 or P52790',\n",
       " 'Q2TB90 or P19367 or P52789 or P52790',\n",
       " 'Q2TB90 or P19367 or P52789 or P52790',\n",
       " 'Q2TB90 or P19367 or P52789 or P52790',\n",
       " 'Q9Y2T3',\n",
       " 'P47989',\n",
       " 'P47989',\n",
       " 'P14618 or P30613',\n",
       " 'P00491',\n",
       " 'Q16854',\n",
       " 'P15309 or P49902 or Q9BXI3 or Q9H0P0 or Q8TCD5 or P21589 or Q969T7 or Q9NYW8 or Q96P26 or Q9NPB1 or C9J2C7',\n",
       " 'P19971 or P00491',\n",
       " '( Q7LG56 and Q99757 and P23921 and Q96LS8 ) or ( Q7LG56 and P10599 and P23921 and Q96LS8 )',\n",
       " '( Q7LG56 and Q99757 and P23921 and Q96LS8 ) or ( Q7LG56 and P10599 and P23921 and Q96LS8 )',\n",
       " '( Q7LG56 and Q99757 and P23921 and Q96LS8 ) or ( Q7LG56 and P10599 and P23921 and Q96LS8 )',\n",
       " '( Q7LG56 and Q99757 and P23921 and Q96LS8 ) or ( Q7LG56 and P10599 and P23921 and Q96LS8 )',\n",
       " '( Q7LG56 and Q99757 and P23921 and Q96LS8 ) or ( Q7LG56 and P10599 and P23921 and Q96LS8 )',\n",
       " '( Q7LG56 and Q99757 and P23921 and Q96LS8 ) or ( Q7LG56 and P10599 and P23921 and Q96LS8 )',\n",
       " '( Q7LG56 and Q99757 and P23921 and Q96LS8 ) or ( Q7LG56 and P10599 and P23921 and Q96LS8 )',\n",
       " '( Q7LG56 and Q99757 and P23921 and Q96LS8 ) or ( Q7LG56 and P10599 and P23921 and Q96LS8 )',\n",
       " 'P15309 or P49902 or Q9BXI3 or Q9H0P0 or Q8TCD5 or P21589 or Q969T7 or Q9NYW8 or Q96P26 or Q9NPB1 or C9J2C7',\n",
       " 'P47989',\n",
       " 'P47989',\n",
       " 'P47989',\n",
       " 'P47989',\n",
       " 'P00491',\n",
       " 'P00491',\n",
       " 'P00492',\n",
       " 'Q9NZK5 or P00813',\n",
       " 'P19971 or P00491',\n",
       " 'P15309 or P49902 or Q9BXI3 or Q9H0P0 or Q8TCD5 or P21589 or Q969T7 or Q9NYW8 or Q96P26 or Q9NPB1 or C9J2C7',\n",
       " 'P19971 or P00491',\n",
       " 'P22102',\n",
       " 'P22102',\n",
       " 'P22234',\n",
       " 'O15067',\n",
       " 'P22234',\n",
       " 'Q9UPQ9 or P30566',\n",
       " 'P31939',\n",
       " 'Q9HA47 or Q9BZX2 or Q9NWZ5',\n",
       " 'Q16774',\n",
       " 'Q8N6M5',\n",
       " 'P30041 or P11678 or Q92626 or A1KZ92 or P22079',\n",
       " 'P30041 or P11678 or Q92626 or A1KZ92 or P22079',\n",
       " 'O94759 or Q9UKK9 or Q3LIE5 or Q9BW91',\n",
       " 'P47989',\n",
       " 'P22392 or Q13232 or O00746 or P56597 or Q9Y5B8 or O75414 or P15531 or P22392',\n",
       " 'P22392 or Q13232 or O00746 or P56597 or Q9Y5B8 or O75414 or P15531 or P22392',\n",
       " 'P22392 or Q13232 or O00746 or P56597 or Q9Y5B8 or O75414 or P15531 or P22392',\n",
       " 'P22392 or Q13232 or O00746 or P56597 or Q9Y5B8 or O75414 or P15531 or P22392',\n",
       " 'P22392 or Q13232 or O00746 or P56597 or Q9Y5B8 or O75414 or P15531 or P22392',\n",
       " 'P22392 or Q13232 or O00746 or P56597 or Q9Y5B8 or O75414 or P15531 or P22392',\n",
       " 'P22392 or Q13232 or O00746 or P56597 or Q9Y5B8 or O75414 or P15531 or P22392',\n",
       " 'P22392 or Q13232 or O00746 or P56597 or Q9Y5B8 or O75414 or P15531 or P22392',\n",
       " 'P22392 or Q13232 or O00746 or P56597 or Q9Y5B8 or O75414 or P15531 or P22392',\n",
       " 'P22392 or Q13232 or O00746 or P56597 or Q9Y5B8 or O75414 or P15531 or P22392',\n",
       " 'P22392 or Q13232 or O00746 or P56597 or Q9Y5B8 or O75414 or P15531 or P22392',\n",
       " 'P22392 or Q13232 or O00746 or P56597 or Q9Y5B8 or O75414 or P15531 or P22392',\n",
       " 'P22392 or Q13232 or O00746 or P56597 or Q9Y5B8 or O75414 or P15531 or P22392',\n",
       " 'P22392 or Q13232 or O00746 or P56597 or Q9Y5B8 or O75414 or P15531 or P22392',\n",
       " 'P22392 or Q13232 or O00746 or P56597 or Q9Y5B8 or O75414 or P15531 or P22392',\n",
       " 'P22392 or Q13232 or O00746 or P56597 or Q9Y5B8 or O75414 or P15531 or P22392',\n",
       " 'P22392 or Q13232 or O00746 or P56597 or Q9Y5B8 or O75414 or P15531 or P22392',\n",
       " 'Q9BYV1',\n",
       " 'Q9NNW7 or Q86VQ6 or Q16881',\n",
       " 'Q9HA47 or Q9BZX2',\n",
       " 'P49902 or Q9BXI3 or Q9H0P0 or Q8TCD5 or P21589 or Q969T7 or Q96P26 or Q9NPB1 or C9J2C7',\n",
       " 'P30085',\n",
       " 'Q9NRF8 or P17812',\n",
       " 'P27708',\n",
       " 'P11172',\n",
       " 'P27708',\n",
       " 'P15309 or P49902 or Q9BXI3 or Q9H0P0 or Q8TCD5 or P21589 or Q969T7 or Q9NYW8 or Q96P26 or Q9NPB1 or C9J2C7',\n",
       " 'Q9Y5L3 or P49961 or O75355 or Q8WVQ1 or O75356 or Q5MY95 or Q9Y227 or O75354',\n",
       " 'Q9Y5L3 or P49961 or O75355 or Q8WVQ1 or O75356 or Q5MY95 or Q9Y227 or O75354',\n",
       " 'O14638 or O95848 or P22413',\n",
       " 'P15309 or P49902 or Q9BXI3 or Q9H0P0 or Q8TCD5 or P21589 or Q969T7 or Q9NYW8 or Q96P26 or Q9NPB1 or C9J2C7',\n",
       " 'P15309 or P49902 or Q9BXI3 or Q9H0P0 or Q8TCD5 or P21589 or Q969T7 or Q9NYW8 or Q96P26 or Q9NPB1 or C9J2C7',\n",
       " 'O75063 or Q9HA64 or Q5SY16 or Q9H479 or Q96C11',\n",
       " 'P49961 or O75355 or Q5MY95',\n",
       " 'P49961 or O75355 or Q5MY95',\n",
       " 'Q9NRF8 or P17812',\n",
       " 'P14618 or P30613',\n",
       " 'Q9BY32',\n",
       " 'Q96BW1',\n",
       " 'Q12882',\n",
       " 'Q16555 or Q14195 or Q14117',\n",
       " 'Q12882',\n",
       " 'Q12882',\n",
       " 'Q12882',\n",
       " 'P15309 or P49902 or Q9BXI3 or Q9H0P0 or Q8TCD5 or P21589 or Q969T7 or Q9NYW8 or Q96P26 or Q9NPB1 or C9J2C7',\n",
       " 'P19971 or P00491',\n",
       " 'P15309 or P49902 or Q9BXI3 or Q9H0P0 or Q8TCD5 or P21589 or Q969T7 or Q9NYW8 or Q96P26 or Q9NPB1 or C9J2C7',\n",
       " 'P30085',\n",
       " 'P27707',\n",
       " 'Q9GZX7 or P32320',\n",
       " 'P11172',\n",
       " 'O95045 or Q16831',\n",
       " 'Q9GZX7 or P32320 or Q8WW27',\n",
       " 'P27708',\n",
       " 'Q02127',\n",
       " 'P23919',\n",
       " 'Q8TCD5 or Q9NPB1',\n",
       " 'Q9BY32 or P33316',\n",
       " 'P04818',\n",
       " 'Q9HA47 or Q9BZX2 or Q9NWZ5',\n",
       " 'Q14117',\n",
       " 'Q9UBR1',\n",
       " 'Q9HA47 or Q9BZX2 or Q9NWZ5',\n",
       " 'Q9HA47 or Q9BZX2 or Q9NWZ5',\n",
       " '( Q7LG56 and Q99757 and P23921 and Q96LS8 ) or ( Q7LG56 and P10599 and P23921 and Q96LS8 )',\n",
       " '( Q7LG56 and Q99757 and P23921 and Q96LS8 ) or ( Q7LG56 and P10599 and P23921 and Q96LS8 )',\n",
       " 'Q9NNW7 or Q86VQ6 or Q16881',\n",
       " 'P23919',\n",
       " 'P23919',\n",
       " '( Q7LG56 and Q99757 and P23921 and Q96LS8 ) or ( Q7LG56 and P10599 and P23921 and Q96LS8 )',\n",
       " '( Q7LG56 and Q99757 and P23921 and Q96LS8 ) or ( Q7LG56 and P10599 and P23921 and Q96LS8 )',\n",
       " 'P04183',\n",
       " 'O00142',\n",
       " 'P14618 or P30613',\n",
       " 'Q96CM3',\n",
       " 'P33316',\n",
       " 'Q9BY32',\n",
       " 'P30085',\n",
       " 'P23919',\n",
       " 'P49961 or O75355 or Q5MY95',\n",
       " 'P30085',\n",
       " 'Q5EBM0',\n",
       " 'P04183',\n",
       " 'P49961 or O75355 or Q5MY95',\n",
       " 'P55263 or P27707',\n",
       " 'Q9Y5L3 or P50570 or O00429 or Q05639 or Q05193 or P49961 or Q7Z2Z2 or P68104 or Q969S9 or P13639 or O75355 or Q96RP9 or Q8WVQ1 or P49411 or O75356 or Q5MY95 or Q9Y227 or O75354 or Q9UQ16',\n",
       " 'Q9HA47 or Q9BZX2 or Q9NWZ5',\n",
       " 'O43252 or O95340',\n",
       " 'O43252 or O95340',\n",
       " 'Q9Y5L3 or P49961 or O75355 or Q8WVQ1 or O75356 or Q5MY95 or Q9Y227 or O75354',\n",
       " 'O00142',\n",
       " 'P32321',\n",
       " 'Q9H773',\n",
       " 'Q16854',\n",
       " 'P00813',\n",
       " 'P23919',\n",
       " 'P04183',\n",
       " 'O95045 or Q16831',\n",
       " 'P22102',\n",
       " 'O00142',\n",
       " 'Q8TCD5 or Q9NPB1',\n",
       " '( Q9NR33 and Q9NRF9 ) or ( P28340 and Q15054 and P49005 and Q9HCU8 ) or ( Q14181 and P09884 ) or ( Q14181 and P28340 and Q15054 and P56282 and P09884 and P49005 and Q9NR33 and Q9NRF9 and Q9HCU8 and Q07864 ) or O60673 or O75417 or P06746 or Q9UNA4 or P40937 or Q5XG87 or Q9UBT6 or Q9NP87 or Q7Z5Q5 or Q9BQG0 or P54098 or Q9UGP5 or Q9Y253 or Q9UHN1',\n",
       " '( O15318 or Q9BT43 ) and ( P51003 or Q9BWT3 or Q6PIY7 or Q9NRJ5 ) and ( Q5VYS8 or Q5TAX3 or Q9H6E5 ) and P52435 and Q9NW08 and P30876 and Q9NVU0 and Q9P1U0 and O95602 and P19388 and O00411 and P61218 and Q9Y535 and P19387 and P36954 and Q9NVV4 and Q9H9Y6 and Q9H1D9 and Q9GZS1 and O15514 and P53803 and O14802 and Q9Y2Y1 and P52434 and P62487 and P05423 and O15160 and P62875 and P24928 and Q9BUI4 and P0DPB5',\n",
       " '( O15318 or Q9BT43 ) and ( P51003 or Q9BWT3 or Q6PIY7 or Q9NRJ5 ) and ( Q5VYS8 or Q5TAX3 or Q9H6E5 ) and P52435 and Q9NW08 and P30876 and Q9NVU0 and Q9P1U0 and O95602 and P19388 and O00411 and P61218 and Q9Y535 and P19387 and P36954 and Q9NVV4 and Q9H9Y6 and Q9H1D9 and Q9GZS1 and O15514 and P53803 and O14802 and Q9Y2Y1 and P52434 and P62487 and P05423 and O15160 and P62875 and P24928 and Q9BUI4 and P0DPB5',\n",
       " '( O60671 and Q99638 ) or Q8WXE1 or Q9BQ50 or Q9NSU2',\n",
       " '( O60671 and Q99638 ) or Q8WXE1 or Q9BQ50 or Q9NSU2',\n",
       " 'P49902 or Q9BXI3 or Q9H0P0 or Q8TCD5 or P21589 or Q969T7 or Q96P26 or Q9NPB1 or C9J2C7',\n",
       " 'P49902 or Q9BXI3 or Q9H0P0 or Q8TCD5 or P21589 or Q969T7 or Q96P26 or Q9NPB1 or C9J2C7',\n",
       " 'P49902 or Q9BXI3 or Q9H0P0 or Q8TCD5 or P21589 or Q969T7 or Q96P26 or Q9NPB1 or C9J2C7',\n",
       " 'P49902 or Q9BXI3 or Q9H0P0 or Q8TCD5 or P21589 or Q969T7 or Q96P26 or Q9NPB1 or C9J2C7',\n",
       " 'P49902 or Q9BXI3 or Q9H0P0 or Q8TCD5 or P21589 or Q969T7 or Q96P26 or Q9NPB1 or C9J2C7',\n",
       " 'P49902 or Q9BXI3 or Q9H0P0 or Q8TCD5 or P21589 or Q969T7 or Q96P26 or Q9NPB1 or C9J2C7',\n",
       " 'Q9Y6K8',\n",
       " 'Q9UIJ7',\n",
       " 'Q9Y6K8',\n",
       " 'P30085',\n",
       " 'P30085',\n",
       " 'P30085',\n",
       " 'P30085',\n",
       " 'P30085',\n",
       " 'P30085',\n",
       " 'P30085',\n",
       " 'P30085',\n",
       " 'P30085',\n",
       " 'P30085',\n",
       " 'P30085',\n",
       " 'P30085',\n",
       " 'Q5EBM0',\n",
       " 'P30085',\n",
       " 'P22392 or Q13232 or O00746 or P56597 or Q9Y5B8 or O75414 or P15531 or P22392',\n",
       " 'Q9BY32',\n",
       " 'Q8TCD5',\n",
       " 'P22392 or P15531 or P22392',\n",
       " 'P22392 or P15531 or P22392',\n",
       " 'P22392 or Q13232 or O00746 or P56597 or Q9Y5B8 or Q5TCS8 or O75414 or P15531 or P22392',\n",
       " 'P22392 or P15531 or P22392',\n",
       " 'P22392 or P15531 or P22392',\n",
       " 'P22392 or Q13232 or O00746 or P56597 or Q9Y5B8 or Q5TCS8 or O75414 or P15531 or P22392',\n",
       " 'P22392 or P15531 or P22392',\n",
       " 'P22392 or P15531 or P22392',\n",
       " 'P22392 or P15531 or P22392',\n",
       " 'P22392 or Q13232 or O00746 or P56597 or Q9Y5B8 or Q5TCS8 or O75414 or P15531 or P22392',\n",
       " 'P22392 or P15531 or P22392',\n",
       " 'P22392 or P15531 or P22392',\n",
       " 'P22392 or P15531 or P22392',\n",
       " 'P22392 or Q13232 or O00746 or P56597 or Q9Y5B8 or Q5TCS8 or O75414 or P15531 or P22392',\n",
       " 'P22392 or Q13232 or O00746 or P56597 or Q9Y5B8 or Q5TCS8 or O75414 or P15531 or P22392',\n",
       " 'P27815 or O60658 or P51160 or Q08493 or Q9Y233 or O95263 or Q08499 or P54750 or Q01064 or Q9HCR9 or P16499 or P35913 or O95998 or O76074 or Q13956 or Q13370 or Q14123 or O43924 or O76083 or Q9NP56 or Q14432 or Q07343 or P18545 or O00408 or Q13946',\n",
       " 'P27815 or O60658 or P51160 or Q08493 or Q9Y233 or O95263 or Q08499 or P54750 or Q01064 or Q9HCR9 or P16499 or P35913 or O95998 or O76074 or Q13956 or Q13370 or Q14123 or O43924 or O76083 or Q9NP56 or Q14432 or Q07343 or P18545 or O00408 or Q13946',\n",
       " 'P27815 or O60658 or P51160 or Q08493 or Q9Y233 or O95263 or Q08499 or P54750 or Q01064 or Q9HCR9 or P16499 or P35913 or O95998 or O76074 or Q13956 or Q13370 or Q14123 or O43924 or O76083 or Q9NP56 or Q14432 or Q07343 or P18545 or O00408 or Q13946',\n",
       " 'Q9UKK9 or Q3LIE5 or Q9BW91',\n",
       " 'Q9UKK9 or Q3LIE5 or Q9BW91',\n",
       " 'Q9HA47 or Q9BZX2 or Q9NWZ5',\n",
       " 'Q9GZX7',\n",
       " 'P30085',\n",
       " 'P30085',\n",
       " 'P30085',\n",
       " 'P30085',\n",
       " 'P30085',\n",
       " 'P30085',\n",
       " 'P30085',\n",
       " 'P30085',\n",
       " 'P30085',\n",
       " 'P30085',\n",
       " 'P30085',\n",
       " 'P30085',\n",
       " 'P30085',\n",
       " 'Q9Y6K8',\n",
       " 'P30085',\n",
       " 'P30085',\n",
       " 'P30085',\n",
       " 'P30085',\n",
       " 'P30085',\n",
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       " 'Q9UBQ7',\n",
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       " 'P09622 and P23434 and P48728 and P23378',\n",
       " 'P09622 and P23434 and P48728 and P23378',\n",
       " 'P09622 and P23434 and P48728 and P23378',\n",
       " 'P09622 and P23434 and P48728 and P23378',\n",
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       " 'Q8IXJ6 or Q8N6T7 or Q9NUN7 or Q96EB6 or Q9NXA8 or Q9Y530 or Q96HD9 or Q9BQ69 or Q02083 or Q9NTG7 or Q96HA8 or Q96AB6 or A1Z1Q3 or Q9NRC8',\n",
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       " 'Q9NYP7 or Q9BW60 or Q9GZR5 or Q9HB03 or A1L3X0 or Q9H5J4 or Q9NXB9',\n",
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       " 'P05091 or P30837 or P49419',\n",
       " 'P09622 and Q02218 and P36957',\n",
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       " 'Q9UDR5 or Q8NBX0',\n",
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       " 'P49419',\n",
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       " '( Q8NEZ4 and Q9UMN6 ) or ( Q8NEZ4 and O14686 ) or Q8IZD2 or O15047 or O43463 or Q8TEK3 or O96028 or Q4FZB7 or Q9NR48 or Q03164 or Q86Y97 or Q96T68 or Q9UPS6 or Q15047 or Q8WTS6 or Q9BZ95 or Q9H5I1 or Q96L73 or Q53H47 or Q9H9B1 or Q9BYW2 or Q9NQR1 or Q9H7B4 or Q96KQ7',\n",
       " '( Q8NEZ4 and Q9UMN6 ) or ( Q8NEZ4 and O14686 ) or Q8IZD2 or O15047 or O43463 or Q8TEK3 or O96028 or Q4FZB7 or Q9NR48 or Q03164 or Q86Y97 or Q96T68 or Q9UPS6 or Q15047 or Q8WTS6 or Q9BZ95 or Q9H5I1 or Q96L73 or Q53H47 or Q9H9B1 or Q9BYW2 or Q9NQR1 or Q9H7B4 or Q96KQ7',\n",
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       " 'Q9NVH6',\n",
       " 'P34897',\n",
       " 'P49189',\n",
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       " '( Q8NEZ4 and Q9UMN6 ) or ( Q8NEZ4 and O14686 ) or Q8IZD2 or O15047 or O43463 or Q8TEK3 or Q15910 or Q92800 or O96028 or Q4FZB7 or Q9NR48 or Q03164 or Q86Y97 or Q96T68 or Q9UPS6 or Q15047 or Q8WTS6 or Q9BZ95 or Q9H5I1 or Q96L73 or Q53H47 or Q9H9B1 or Q9BYW2 or Q9NQR1 or Q96KQ7',\n",
       " '( Q8NEZ4 and Q9UMN6 ) or ( Q8NEZ4 and O14686 ) or Q8IZD2 or O15047 or O43463 or Q8TEK3 or Q15910 or Q92800 or O96028 or Q4FZB7 or Q9NR48 or Q03164 or Q86Y97 or Q96T68 or Q9UPS6 or Q15047 or Q8WTS6 or Q9BZ95 or Q9H5I1 or Q96L73 or Q53H47 or Q9H9B1 or Q9BYW2 or Q9NQR1 or Q96KQ7',\n",
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       " 'Q99714 and P40939 and Q16836',\n",
       " 'P24752',\n",
       " 'P20711',\n",
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       " 'P05091 or P30837 or P49419',\n",
       " 'Q8N5Z0 or Q6YP21 or Q16773',\n",
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       " 'P35914',\n",
       " 'P20711',\n",
       " 'P19801 or P27338 or Q16853 or O75106 or P21397',\n",
       " 'P43353 or P30838 or P48448 or P47895',\n",
       " 'P43353 or P30838 or P48448 or P47895',\n",
       " 'P43353 or P30838 or P48448 or P47895',\n",
       " 'P43353 or P30838 or P48448 or P47895',\n",
       " 'Q06278',\n",
       " 'Q06278',\n",
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       " 'P19801 or Q16853 or O75106',\n",
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       " 'P14679',\n",
       " 'P14679',\n",
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       " 'P21953 and Q6ZNR0 and P12694',\n",
       " 'P11182',\n",
       " 'P21953 and Q6ZNR0 and P12694',\n",
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       " 'Q9BPX1 or Q9H2F3 or Q13268 or Q9BUP3 or Q8IZV5 or Q5I0G3 or Q96NR8 or Q8N4T8 or Q13363 or Q8NBN7 or Q9BUT1 or Q7Z5J1 or Q8NEX9 or Q8N3Y7 or P80365 or A6NKP2 or Q8WUS8 or Q9NZC7 or Q04828 or P11766 or O60218 or Q8NBQ5 or P17516 or Q92506 or C9JRZ8 or Q9HBH5',\n",
       " 'Q96RQ3 and Q9HCC0',\n",
       " 'Q96RQ3 and Q9HCC0',\n",
       " 'P80404',\n",
       " 'O95822',\n",
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       " 'P00439',\n",
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       " 'Q8N5Z0 or Q6YP21 or Q16773',\n",
       " 'Q16719',\n",
       " 'Q16719',\n",
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       " 'Q92947',\n",
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       " 'O95050',\n",
       " 'P19801 or P27338 or P21397',\n",
       " 'P51648 or P05091 or P30837 or P49189 or P49419',\n",
       " 'P21964 or Q8WZ04 or A0A2R8Y5M8',\n",
       " 'P14902 or Q6ZQW0',\n",
       " 'Q63HM1',\n",
       " 'P20711',\n",
       " 'P27338 or P21397',\n",
       " 'Q8NHS2',\n",
       " 'P10620 or Q9H4Y5 or P09211 or Q99735 or A0A087WY67 or O43708 or P0CG30 or P09488 or P46439 or P21266 or O14880 or P78417 or O60760 or Q03013 or O15217 or Q16772 or Q7RTV2 or Q9Y2Q3 or P28161 or P08263 or P09210',\n",
       " 'P17174 or P00505 or P17735',\n",
       " 'P32754',\n",
       " 'P14174',\n",
       " 'P07101',\n",
       " 'P14679',\n",
       " 'P21964 or Q8WZ04 or A0A2R8Y5M8',\n",
       " 'P20711',\n",
       " 'P21964 or Q8WZ04 or A0A2R8Y5M8',\n",
       " 'P21964 or Q8WZ04 or A0A2R8Y5M8',\n",
       " '( O14744 and Q99873 ) or Q8N6R0 or Q8WVM0 or Q13395 or Q7Z4G4 or Q9BUU2 or Q9UET6 or O43709 or Q96IZ6 or Q9H867 or Q5TEU4 or Q8N3J2 or Q8TBK2 or P22087 or Q8IY81 or Q5HYK3 or Q9NR22 or P46087 or Q9Y5R4 or Q96CB9 or Q9NUP7 or Q9UI43 or Q96AZ1 or Q9H825 or Q92979 or Q86W50 or Q96P11 or O43159 or Q9NVM4 or Q96RS0 or Q96BT7 or Q9NRN9 or Q8IXQ9 or Q5VZV1 or Q86X55 or Q9NRG4 or Q8WXB1 or P0DPD6 or Q8TBZ6 or Q9HCE5 or Q7L2J0 or Q8WVE0 or Q9Y5N5 or P55345 or Q6IPR3 or Q9H5Q4 or Q6P2P2 or Q6P1Q9 or Q6PF06 or Q86VU5 or Q9H7H0 or O60294 or A6NJ78 or Q6UX53 or O95568 or Q9HC36 or Q7L0Y3 or Q9H649 or Q8NE18 or Q8IYT2 or Q86XA0 or Q9H9B1 or Q9NQR1 or O60678 or Q9H8H3 or Q7Z5W3 or A6NHQ2 or Q96LA8 or Q5JPI9 or Q96KQ7 or Q9UIC8 or Q8TCB7 or A8MUP2 or Q8TEA1 or Q9P272 or Q6IN84',\n",
       " 'P21964 or Q8WZ04 or A0A2R8Y5M8',\n",
       " 'P20711',\n",
       " 'P09172',\n",
       " 'P11086',\n",
       " 'P27338 or P21397',\n",
       " 'P21964 or Q8WZ04 or A0A2R8Y5M8',\n",
       " 'P27338 or P21397',\n",
       " 'P43353 or P30838 or P48448 or P47895',\n",
       " 'P43353 or P30838 or P48448 or P47895',\n",
       " 'P21964 or Q8WZ04 or A0A2R8Y5M8',\n",
       " 'P27338 or P21397',\n",
       " 'P27338 or P21397',\n",
       " 'P43353 or P30838 or P48448 or P47895',\n",
       " 'P43353 or P30838 or P48448 or P47895',\n",
       " 'P21964 or Q8WZ04 or A0A2R8Y5M8',\n",
       " 'Q8IWW8 or P28332 or P07327 or P40394 or P00325 or P11766 or P08319 or P00326',\n",
       " 'P21964 or Q8WZ04 or A0A2R8Y5M8',\n",
       " 'P19801 or P27338 or Q16853 or O75106 or P21397',\n",
       " 'P43353 or P30838 or P48448 or P47895',\n",
       " 'P43353 or P30838 or P48448 or P47895',\n",
       " 'P21964 or Q8WZ04 or A0A2R8Y5M8',\n",
       " 'P21964 or Q8WZ04 or A0A2R8Y5M8',\n",
       " 'P27338 or P21397',\n",
       " 'P43353 or P30838 or P48448 or P47895',\n",
       " 'P43353 or P30838 or P48448 or P47895',\n",
       " 'P17174 or P00505 or P17735',\n",
       " 'Q96RQ9',\n",
       " 'P14174',\n",
       " 'P32754',\n",
       " 'Q93099',\n",
       " 'O43708',\n",
       " 'P16930',\n",
       " 'P20711',\n",
       " 'P21964 or Q8WZ04 or O95050 or A0A2R8Y5M8',\n",
       " 'P19801 or P27338 or Q16853 or O75106 or P21397',\n",
       " 'P43353 or P30838 or P48448 or P47895',\n",
       " 'P43353 or P30838 or P48448 or P47895',\n",
       " 'P36537 or Q6UWM9 or Q9BY64 or Q6NUS8 or P06133 or P19224 or Q3SY77 or P16662 or P0DTE4 or P54855 or O75795 or O75310 or P35504 or O60656 or P22309 or Q9HAW9 or Q9HAW8 or P35503 or Q9HAW7 or P22310',\n",
       " 'P36537 or Q6UWM9 or Q9BY64 or Q6NUS8 or P06133 or P19224 or Q3SY77 or P16662 or P0DTE4 or P54855 or O75795 or O75310 or P35504 or O60656 or P22309 or Q9HAW9 or Q9HAW8 or P35503 or Q9HAW7 or P22310',\n",
       " 'P36537 or Q6UWM9 or Q9BY64 or Q6NUS8 or P06133 or P19224 or Q3SY77 or P16662 or P0DTE4 or P54855 or O75795 or O75310 or P35504 or O60656 or P22309 or Q9HAW9 or Q9HAW8 or P35503 or Q9HAW7 or P22310',\n",
       " 'P36537 or Q6UWM9 or Q9BY64 or Q6NUS8 or P06133 or P19224 or Q3SY77 or P16662 or P0DTE4 or P54855 or O75795 or O75310 or P35504 or O60656 or P22309 or Q9HAW9 or Q9HAW8 or P35503 or Q9HAW7 or P22310',\n",
       " 'P14679',\n",
       " 'P30041 or P11678 or Q92626 or A1KZ92 or P22079',\n",
       " 'P10620 or Q9H4Y5 or P09211 or Q99735 or A0A087WY67 or O43708 or P0CG30 or P09488 or P46439 or P21266 or O14880 or P78417 or O60760 or Q03013 or O15217 or Q16772 or Q7RTV2 or Q9Y2Q3 or P28161 or P08263 or P09210',\n",
       " 'P05164 or P07202 or P30041 or P11678 or P22079',\n",
       " 'Q08257',\n",
       " 'P10620 or Q9H4Y5 or P09211 or Q99735 or A0A087WY67 or O43708 or P0CG30 or P09488 or P46439 or P21266 or O14880 or P78417 or O60760 or Q03013 or O15217 or Q16772 or Q7RTV2 or Q9Y2Q3 or P28161 or P08263 or P09210',\n",
       " 'Q08257',\n",
       " 'Q08257',\n",
       " 'P10620 or Q9H4Y5 or P09211 or Q99735 or A0A087WY67 or O43708 or P0CG30 or P09488 or P46439 or P21266 or O14880 or P78417 or O60760 or Q03013 or O15217 or Q16772 or Q7RTV2 or Q9Y2Q3 or P28161 or P08263 or P09210',\n",
       " 'Q08257',\n",
       " 'P10620 or Q9H4Y5 or P09211 or Q99735 or A0A087WY67 or O43708 or P0CG30 or P09488 or P46439 or P21266 or O14880 or P78417 or O60760 or Q03013 or O15217 or Q16772 or Q7RTV2 or Q9Y2Q3 or P28161 or P08263 or P09210',\n",
       " 'P55073 or Q92813 or P49895',\n",
       " 'P55073 or Q92813 or P49895',\n",
       " 'P36537 or Q6UWM9 or Q9BY64 or Q6NUS8 or P06133 or P19224 or Q3SY77 or P16662 or P0DTE4 or P54855 or O75795 or O75310 or P35504 or O60656 or P22309 or Q9HAW9 or Q9HAW8 or P35503 or Q9HAW7 or P22310',\n",
       " 'P52848 or Q9Y2C2 or O43529 or Q9H2A9 or Q9BR01 or Q9GZS9 or O60243 or Q9H3R1 or Q8NCG5 or Q9NS84 or Q7LGA3 or Q7L1S5 or Q9H3Q3 or O95803 or P52849 or Q96MM7 or O43704 or Q9Y4C5 or Q96A11 or Q9GZX3 or Q8IZP7 or Q96RP7 or O75897 or O00338',\n",
       " 'P36537 or Q6UWM9 or Q9BY64 or Q6NUS8 or P06133 or P19224 or Q3SY77 or P16662 or P0DTE4 or P54855 or O75795 or O75310 or P35504 or O60656 or P22309 or Q9HAW9 or Q9HAW8 or P35503 or Q9HAW7 or P22310',\n",
       " 'P08842',\n",
       " 'Q92813 or P49895',\n",
       " 'Q92813 or P49895',\n",
       " 'P36537 or Q6UWM9 or Q9BY64 or Q6NUS8 or P06133 or P19224 or Q3SY77 or P16662 or P0DTE4 or P54855 or O75795 or O75310 or P35504 or O60656 or P22309 or Q9HAW9 or Q9HAW8 or P35503 or Q9HAW7 or P22310',\n",
       " 'P36537 or Q6UWM9 or Q9BY64 or Q6NUS8 or P06133 or P19224 or Q3SY77 or P16662 or P0DTE4 or P54855 or O75795 or O75310 or P35504 or O60656 or P22309 or Q9HAW9 or Q9HAW8 or P35503 or Q9HAW7 or P22310',\n",
       " 'O43704 or O00338',\n",
       " 'P08842',\n",
       " 'Q92813 or P49895',\n",
       " 'Q92813 or P49895',\n",
       " 'P36537 or Q6UWM9 or Q9BY64 or Q6NUS8 or P06133 or P19224 or Q3SY77 or P16662 or P0DTE4 or P54855 or O75795 or O75310 or P35504 or O60656 or P22309 or Q9HAW9 or Q9HAW8 or P35503 or Q9HAW7 or P22310',\n",
       " 'P36537 or Q6UWM9 or Q9BY64 or Q6NUS8 or P06133 or P19224 or Q3SY77 or P16662 or P0DTE4 or P54855 or O75795 or O75310 or P35504 or O60656 or P22309 or Q9HAW9 or Q9HAW8 or P35503 or Q9HAW7 or P22310',\n",
       " 'O43704 or O00338',\n",
       " 'P08842',\n",
       " 'Q92813 or P49895',\n",
       " 'Q92813 or P49895',\n",
       " 'O43704 or O00338',\n",
       " 'P08842',\n",
       " 'Q92813 or P49895',\n",
       " 'Q92813 or P49895',\n",
       " 'P14679',\n",
       " 'P10620 or Q9H4Y5 or P09211 or Q99735 or A0A087WY67 or O43708 or P0CG30 or P09488 or P46439 or P21266 or O14880 or P78417 or O60760 or Q03013 or O15217 or Q16772 or Q7RTV2 or Q9Y2Q3 or P28161 or P08263 or P09210',\n",
       " 'Q08257',\n",
       " 'P10620 or Q9H4Y5 or P09211 or Q99735 or A0A087WY67 or O43708 or P0CG30 or P09488 or P46439 or P21266 or O14880 or P78417 or O60760 or Q03013 or O15217 or Q16772 or Q7RTV2 or Q9Y2Q3 or P28161 or P08263 or P09210',\n",
       " 'P40126',\n",
       " 'P14679 or P17643',\n",
       " 'P30041 or P11678 or Q92626 or A1KZ92 or P22079',\n",
       " 'Q6GMR7',\n",
       " 'P00439',\n",
       " 'Q6IB77',\n",
       " 'Q9NZL9 or Q00266 or P31153',\n",
       " 'P23526 or Q96HN2 or O43865',\n",
       " 'P0DN79',\n",
       " 'P32929',\n",
       " 'P17174 or P00505',\n",
       " 'Q99707',\n",
       " 'A0A1B0GUT4 or Q03154',\n",
       " 'P27169 or Q15166 or Q15165',\n",
       " 'Q8N159',\n",
       " 'P25325 or Q16762',\n",
       " 'Q674R7 or Q9NNW7 or Q86VQ6 or Q16881',\n",
       " '( Q9UBC3 and P26358 ) or O14717 or Q9Y6K1 or Q9UJW3',\n",
       " 'P51687',\n",
       " 'P32929',\n",
       " 'P0DN79',\n",
       " 'P0DMM9',\n",
       " 'Q9BV20',\n",
       " 'Q96GX9',\n",
       " 'Q9UHY7',\n",
       " 'Q9BV57',\n",
       " 'Q9BV57',\n",
       " 'Q96RQ9',\n",
       " 'P17735',\n",
       " 'Q8N159',\n",
       " 'Q8N159',\n",
       " 'P25325 or Q16762',\n",
       " 'P25325 or Q16762',\n",
       " 'P07195 or Q8IX04 or P07864 or Q6ZMR3 or Q9BYZ2',\n",
       " 'P25325 or Q16762',\n",
       " 'P21953 or P09622 or P30041 or P11678 or Q92626 or Q6ZNR0 or A1KZ92 or P22079 or P12694 or F5H5P2',\n",
       " 'P0DMM9',\n",
       " 'P17174 or P00505',\n",
       " 'P00505',\n",
       " 'P40925 or Q5I0G3',\n",
       " 'P40926',\n",
       " '( Q9UBC3 and P26358 ) or O14717 or Q9Y6K1 or Q9UJW3',\n",
       " 'P32929',\n",
       " 'P00505',\n",
       " 'P00390',\n",
       " 'P00390',\n",
       " 'O14841',\n",
       " 'P11766',\n",
       " 'P10768',\n",
       " 'Q96SL4 or Q06830 or P30041 or P30044 or Q8TED1 or P30048 or P36969 or P32119 or P18283 or P59796 or P22352 or O75715 or P07203',\n",
       " 'Q96SL4 or Q06830 or P30041 or P30044 or Q8TED1 or P30048 or P36969 or P32119 or P18283 or P59796 or P22352 or O75715 or P07203',\n",
       " 'Q96SL4 or Q06830 or P30041 or P30044 or Q8TED1 or P30048 or P36969 or P32119 or P18283 or P59796 or P22352 or O75715 or P07203',\n",
       " 'P36269 or P19440 or Q14390 or Q9UJ14 or P36268 or Q6P531 or B5MD39',\n",
       " 'P36269 or P19440 or Q14390 or Q9UJ14 or P36268 or Q6P531 or B5MD39',\n",
       " 'P48506 and P48507',\n",
       " 'P48637',\n",
       " 'P28838 or P55786 or P15144',\n",
       " 'P28838 or P55786 or P15144',\n",
       " 'O75223 or Q9BVM4',\n",
       " 'P36269 or P19440 or Q14390 or Q9UJ14 or P36268 or Q9BX51 or Q6P531',\n",
       " 'O75223 or Q9BVM4',\n",
       " 'Q9NWM0',\n",
       " 'P51648 or P05091 or P30837 or P49189 or P49419',\n",
       " 'Q99259 or Q05329',\n",
       " 'P80404',\n",
       " 'Q9UBR1',\n",
       " 'A5YM72',\n",
       " 'Q96KP4 or Q96KN2',\n",
       " 'P51648 or P05091 or P30837 or P49189 or P49419',\n",
       " 'P49189',\n",
       " 'P40939 and Q08426 and P30084',\n",
       " 'P19801 or Q16853 or O75106',\n",
       " 'P51648 or P05091 or P30837 or P49189 or P49419',\n",
       " 'O43252 or O95340',\n",
       " 'O43252 or O95340',\n",
       " 'Q9NNW7 or Q86VQ6 or Q16881',\n",
       " 'P49903 or Q99611',\n",
       " 'Q96I15',\n",
       " 'P32929',\n",
       " 'P0DN79',\n",
       " 'P23526 or Q96HN2 or O43865',\n",
       " 'P32929',\n",
       " 'P31513 or Q01740 or P31512 or Q99518 or P49326',\n",
       " 'Q9NZL9 or Q00266 or P31153',\n",
       " 'Q96I15',\n",
       " 'P56192 or Q96GW9',\n",
       " 'P14920',\n",
       " '( Q9UBC3 and P26358 ) or O14717 or Q9Y6K1 or Q9UJW3',\n",
       " 'P14920',\n",
       " 'P14920',\n",
       " 'P21953 and Q6ZNR0 and P12694',\n",
       " 'P16219 or P45954',\n",
       " 'P40939 and Q08426 and P30084',\n",
       " 'Q6NVY1',\n",
       " 'P51648 or P05091 or P30837 or Q06278 or P49189 or P49419',\n",
       " 'Q02252',\n",
       " 'P21953 and Q6ZNR0 and P12694',\n",
       " 'P26440',\n",
       " 'Q96RQ3 and Q9HCC0',\n",
       " 'Q13825',\n",
       " 'P21953 and Q6ZNR0 and P12694',\n",
       " 'P16219 or P45954',\n",
       " 'P40939 and Q08426 and P30084',\n",
       " 'Q06278',\n",
       " 'Q9BYV1 or P80404',\n",
       " 'Q9H6R3 or Q9NR19 or Q9NUB1',\n",
       " 'Q99714 or Q16836',\n",
       " 'P21953 and Q6ZNR0 and P12694',\n",
       " 'Q13231 or Q9BZP6',\n",
       " 'P07686 or Q8WVB3 or P06865',\n",
       " ...]"
      ]
     },
     "execution_count": 120,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "#^Doing the same for ReactionRule.\n",
    "ReactionRule = model.ReactionRule.tolist()\n",
    "ReactionRule"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 127,
   "id": "unnecessary-junction",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>0</th>\n",
       "      <th>1</th>\n",
       "      <th>2</th>\n",
       "      <th>3</th>\n",
       "      <th>4</th>\n",
       "      <th>5</th>\n",
       "      <th>6</th>\n",
       "      <th>7</th>\n",
       "      <th>8</th>\n",
       "      <th>9</th>\n",
       "      <th>...</th>\n",
       "      <th>343</th>\n",
       "      <th>344</th>\n",
       "      <th>345</th>\n",
       "      <th>346</th>\n",
       "      <th>347</th>\n",
       "      <th>348</th>\n",
       "      <th>349</th>\n",
       "      <th>350</th>\n",
       "      <th>ReactionID</th>\n",
       "      <th>ReactionRule</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>HOT_HUMAN</td>\n",
       "      <td>ADH1G_HUMAN</td>\n",
       "      <td>ADHX_HUMAN</td>\n",
       "      <td>PTGR3_HUMAN</td>\n",
       "      <td>ADH1B_HUMAN</td>\n",
       "      <td>ADH1A_HUMAN</td>\n",
       "      <td>ADH6_HUMAN</td>\n",
       "      <td>ADH7_HUMAN</td>\n",
       "      <td>ADH4_HUMAN</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>HMR_3905</td>\n",
       "      <td>Q8IWW8 or P28332 or Q8N4Q0 or P07327 or P40394...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>AK1A1_HUMAN</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>HMR_3907</td>\n",
       "      <td>P14550</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>ACSA_HUMAN</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>HMR_4097</td>\n",
       "      <td>Q9NR19</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>ACS2L_HUMAN</td>\n",
       "      <td>ACSS3_HUMAN</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>HMR_4099</td>\n",
       "      <td>Q9H6R3 or Q9NUB1</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>ACSA_HUMAN</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>HMR_4108</td>\n",
       "      <td>Q9NR19</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>...</th>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>13082</th>\n",
       "      <td>NTCP_HUMAN</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>HMR_10119</td>\n",
       "      <td>Q14973</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>13083</th>\n",
       "      <td>NTCP_HUMAN</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>HMR_10120</td>\n",
       "      <td>Q14973</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>13088</th>\n",
       "      <td>MRP3_HUMAN</td>\n",
       "      <td>ABCBB_HUMAN</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>HMR_10125</td>\n",
       "      <td>O95342 or O15438</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>13089</th>\n",
       "      <td>MRP3_HUMAN</td>\n",
       "      <td>ABCBB_HUMAN</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>HMR_10126</td>\n",
       "      <td>O95342 or O15438</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>13090</th>\n",
       "      <td>NTCP_HUMAN</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>HMR_10127</td>\n",
       "      <td>Q14973</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>8036 rows × 353 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "                 0            1           2            3            4  \\\n",
       "0        HOT_HUMAN  ADH1G_HUMAN  ADHX_HUMAN  PTGR3_HUMAN  ADH1B_HUMAN   \n",
       "1      AK1A1_HUMAN         None        None         None         None   \n",
       "2       ACSA_HUMAN         None        None         None         None   \n",
       "3      ACS2L_HUMAN  ACSS3_HUMAN        None         None         None   \n",
       "4       ACSA_HUMAN         None        None         None         None   \n",
       "...            ...          ...         ...          ...          ...   \n",
       "13082   NTCP_HUMAN         None        None         None         None   \n",
       "13083   NTCP_HUMAN         None        None         None         None   \n",
       "13088   MRP3_HUMAN  ABCBB_HUMAN        None         None         None   \n",
       "13089   MRP3_HUMAN  ABCBB_HUMAN        None         None         None   \n",
       "13090   NTCP_HUMAN         None        None         None         None   \n",
       "\n",
       "                 5           6           7           8     9  ...   343   344  \\\n",
       "0      ADH1A_HUMAN  ADH6_HUMAN  ADH7_HUMAN  ADH4_HUMAN  None  ...  None  None   \n",
       "1             None        None        None        None  None  ...  None  None   \n",
       "2             None        None        None        None  None  ...  None  None   \n",
       "3             None        None        None        None  None  ...  None  None   \n",
       "4             None        None        None        None  None  ...  None  None   \n",
       "...            ...         ...         ...         ...   ...  ...   ...   ...   \n",
       "13082         None        None        None        None  None  ...  None  None   \n",
       "13083         None        None        None        None  None  ...  None  None   \n",
       "13088         None        None        None        None  None  ...  None  None   \n",
       "13089         None        None        None        None  None  ...  None  None   \n",
       "13090         None        None        None        None  None  ...  None  None   \n",
       "\n",
       "        345   346   347   348   349   350 ReactionID  \\\n",
       "0      None  None  None  None  None  None   HMR_3905   \n",
       "1      None  None  None  None  None  None   HMR_3907   \n",
       "2      None  None  None  None  None  None   HMR_4097   \n",
       "3      None  None  None  None  None  None   HMR_4099   \n",
       "4      None  None  None  None  None  None   HMR_4108   \n",
       "...     ...   ...   ...   ...   ...   ...        ...   \n",
       "13082  None  None  None  None  None  None  HMR_10119   \n",
       "13083  None  None  None  None  None  None  HMR_10120   \n",
       "13088  None  None  None  None  None  None  HMR_10125   \n",
       "13089  None  None  None  None  None  None  HMR_10126   \n",
       "13090  None  None  None  None  None  None  HMR_10127   \n",
       "\n",
       "                                            ReactionRule  \n",
       "0      Q8IWW8 or P28332 or Q8N4Q0 or P07327 or P40394...  \n",
       "1                                                 P14550  \n",
       "2                                                 Q9NR19  \n",
       "3                                       Q9H6R3 or Q9NUB1  \n",
       "4                                                 Q9NR19  \n",
       "...                                                  ...  \n",
       "13082                                             Q14973  \n",
       "13083                                             Q14973  \n",
       "13088                                   O95342 or O15438  \n",
       "13089                                   O95342 or O15438  \n",
       "13090                                             Q14973  \n",
       "\n",
       "[8036 rows x 353 columns]"
      ]
     },
     "execution_count": 127,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "#Adding reaction IDs and rules to new dataframe.\n",
    "separated_ids['ReactionID'] = ReactionID\n",
    "separated_ids['ReactionRule'] = ReactionRule\n",
    "separated_ids"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 141,
   "id": "demonstrated-trade",
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "0        HOT_HUMAN\n",
      "1      ADH1G_HUMAN\n",
      "2       ADHX_HUMAN\n",
      "3      PTGR3_HUMAN\n",
      "4      ADH1B_HUMAN\n",
      "          ...     \n",
      "346           None\n",
      "347           None\n",
      "348           None\n",
      "349           None\n",
      "350           None\n",
      "Name: 0, Length: 351, dtype: object \n",
      " first ID first row:  HOT_HUMAN\n"
     ]
    }
   ],
   "source": [
    "#Creating new variable to access the IDs.\n",
    "model_ids_3 = separated_ids.iloc[:,0:351]\n",
    "print((model_ids_3.iloc[0,:]),'\\n','first ID first row: ',(model_ids_3.iloc[0,0])) #Checking how to access reactions."
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 149,
   "id": "photographic-boundary",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "0       ADH7_HUMAN\n",
       "1       ADHX_HUMAN\n",
       "2      PTGR3_HUMAN\n",
       "3      AK1A1_HUMAN\n",
       "4       DLDH_HUMAN\n",
       "          ...     \n",
       "709     PEPD_HUMAN\n",
       "710    ABCA4_HUMAN\n",
       "711    AT11C_HUMAN\n",
       "712    ACO13_HUMAN\n",
       "713      SAP_HUMAN\n",
       "Length: 714, dtype: object"
      ]
     },
     "execution_count": 149,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "#Converting overlap to a series for set intersection method.\n",
    "final_overlap = pd.Series(final_overlap)\n",
    "final_overlap"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 168,
   "id": "voluntary-broadcasting",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
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       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>ID</th>\n",
       "      <th>ID.1</th>\n",
       "      <th>ID.2</th>\n",
       "      <th>ID.3</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>a</td>\n",
       "      <td>b</td>\n",
       "      <td>c</td>\n",
       "      <td>d</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>a</td>\n",
       "      <td>j</td>\n",
       "      <td>h</td>\n",
       "      <td>b</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>b</td>\n",
       "      <td>k</td>\n",
       "      <td>l</td>\n",
       "      <td>i</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "  ID ID.1 ID.2 ID.3\n",
       "0  a    b    c    d\n",
       "1  a    j    h    b\n",
       "2  b    k    l    i"
      ]
     },
     "execution_count": 168,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "#Using test datasets/lists as a positive control for calculating overlap.\n",
    "testing = pd.read_csv(r'/Users/katemeeson/Desktop/testing.csv')\n",
    "testing "
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 169,
   "id": "forward-boards",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "0    a\n",
       "1    b\n",
       "2    c\n",
       "dtype: object"
      ]
     },
     "execution_count": 169,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "testing_list = ['a','b','c']\n",
    "testing_series = pd.Series(testing_list)\n",
    "testing_series"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 170,
   "id": "silent-casting",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>0</th>\n",
       "      <th>1</th>\n",
       "      <th>2</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>c</td>\n",
       "      <td>a</td>\n",
       "      <td>b</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>a</td>\n",
       "      <td>b</td>\n",
       "      <td>None</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>b</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "   0     1     2\n",
       "0  c     a     b\n",
       "1  a     b  None\n",
       "2  b  None  None"
      ]
     },
     "execution_count": 170,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "test_overlap = []\n",
    "\n",
    "for i in range(0,3):\n",
    "    test_overlap.append(set(testing.iloc[i,:]).intersection(testing_series))\n",
    "    continue\n",
    "    \n",
    "test_overlapdf = pd.DataFrame(test_overlap)\n",
    "\n",
    "test_overlapdf"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 171,
   "id": "retained-phrase",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "8036"
      ]
     },
     "execution_count": 171,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "len(model_ids_3)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 292,
   "id": "polar-magnitude",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>IDs</th>\n",
       "      <th>IDs.1</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>2AAA_HUMAN</td>\n",
       "      <td>P30153</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>2AAB_HUMAN</td>\n",
       "      <td>P30154</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>3HIDH_HUMAN</td>\n",
       "      <td>P31937</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>4EBP3_HUMAN</td>\n",
       "      <td>O60516</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>4F2_HUMAN</td>\n",
       "      <td>P08195</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>...</th>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>709</th>\n",
       "      <td>XPO7_HUMAN</td>\n",
       "      <td>Q9UIA9</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>710</th>\n",
       "      <td>XYLT1_HUMAN</td>\n",
       "      <td>Q86Y38</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>711</th>\n",
       "      <td>XYLT2_HUMAN</td>\n",
       "      <td>Q9H1B5</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>712</th>\n",
       "      <td>YES_HUMAN</td>\n",
       "      <td>P07947</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>713</th>\n",
       "      <td>ZCCHV_HUMAN</td>\n",
       "      <td>Q7Z2W4</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>714 rows × 2 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "             IDs   IDs.1\n",
       "0     2AAA_HUMAN  P30153\n",
       "1     2AAB_HUMAN  P30154\n",
       "2    3HIDH_HUMAN  P31937\n",
       "3    4EBP3_HUMAN  O60516\n",
       "4      4F2_HUMAN  P08195\n",
       "..           ...     ...\n",
       "709   XPO7_HUMAN  Q9UIA9\n",
       "710  XYLT1_HUMAN  Q86Y38\n",
       "711  XYLT2_HUMAN  Q9H1B5\n",
       "712    YES_HUMAN  P07947\n",
       "713  ZCCHV_HUMAN  Q7Z2W4\n",
       "\n",
       "[714 rows x 2 columns]"
      ]
     },
     "execution_count": 292,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "#CSV with Uniprot IDs (as well as protien names from overlap), so we can compare to reaction rules.\n",
    "overlap_uniprot_ids = pd.read_csv(r'/Users/katemeeson/Desktop/160620213.csv')\n",
    "overlap_uniprot_ids"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 294,
   "id": "invalid-lesbian",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "0      P30153\n",
       "1      P30154\n",
       "2      P31937\n",
       "3      O60516\n",
       "4      P08195\n",
       "        ...  \n",
       "709    Q9UIA9\n",
       "710    Q86Y38\n",
       "711    Q9H1B5\n",
       "712    P07947\n",
       "713    Q7Z2W4\n",
       "Name: IDs.1, Length: 714, dtype: object"
      ]
     },
     "execution_count": 294,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "#Creating variable for UniprotID column, ready for comparison.\n",
    "overlap_uniprot_ids_2 = overlap_uniprot_ids.iloc[:,1]\n",
    "overlap_uniprot_ids_2"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 174,
   "id": "secure-nothing",
   "metadata": {
    "scrolled": true
   },
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
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       "\n",
       "    .dataframe thead th {\n",
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       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>0</th>\n",
       "      <th>1</th>\n",
       "      <th>2</th>\n",
       "      <th>3</th>\n",
       "      <th>4</th>\n",
       "      <th>5</th>\n",
       "      <th>6</th>\n",
       "      <th>7</th>\n",
       "      <th>8</th>\n",
       "      <th>9</th>\n",
       "      <th>...</th>\n",
       "      <th>54</th>\n",
       "      <th>55</th>\n",
       "      <th>56</th>\n",
       "      <th>57</th>\n",
       "      <th>58</th>\n",
       "      <th>59</th>\n",
       "      <th>60</th>\n",
       "      <th>61</th>\n",
       "      <th>62</th>\n",
       "      <th>63</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>PTGR3_HUMAN</td>\n",
       "      <td>ADH7_HUMAN</td>\n",
       "      <td>ADHX_HUMAN</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>AK1A1_HUMAN</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>...</th>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8031</th>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8032</th>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8033</th>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8034</th>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8035</th>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>8036 rows × 64 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "               0           1           2     3     4     5     6     7     8   \\\n",
       "0     PTGR3_HUMAN  ADH7_HUMAN  ADHX_HUMAN  None  None  None  None  None  None   \n",
       "1     AK1A1_HUMAN        None        None  None  None  None  None  None  None   \n",
       "2            None        None        None  None  None  None  None  None  None   \n",
       "3            None        None        None  None  None  None  None  None  None   \n",
       "4            None        None        None  None  None  None  None  None  None   \n",
       "...           ...         ...         ...   ...   ...   ...   ...   ...   ...   \n",
       "8031         None        None        None  None  None  None  None  None  None   \n",
       "8032         None        None        None  None  None  None  None  None  None   \n",
       "8033         None        None        None  None  None  None  None  None  None   \n",
       "8034         None        None        None  None  None  None  None  None  None   \n",
       "8035         None        None        None  None  None  None  None  None  None   \n",
       "\n",
       "        9   ...    54    55    56    57    58    59    60    61    62    63  \n",
       "0     None  ...  None  None  None  None  None  None  None  None  None  None  \n",
       "1     None  ...  None  None  None  None  None  None  None  None  None  None  \n",
       "2     None  ...  None  None  None  None  None  None  None  None  None  None  \n",
       "3     None  ...  None  None  None  None  None  None  None  None  None  None  \n",
       "4     None  ...  None  None  None  None  None  None  None  None  None  None  \n",
       "...    ...  ...   ...   ...   ...   ...   ...   ...   ...   ...   ...   ...  \n",
       "8031  None  ...  None  None  None  None  None  None  None  None  None  None  \n",
       "8032  None  ...  None  None  None  None  None  None  None  None  None  None  \n",
       "8033  None  ...  None  None  None  None  None  None  None  None  None  None  \n",
       "8034  None  ...  None  None  None  None  None  None  None  None  None  None  \n",
       "8035  None  ...  None  None  None  None  None  None  None  None  None  None  \n",
       "\n",
       "[8036 rows x 64 columns]"
      ]
     },
     "execution_count": 174,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "#Use this to create overlap dataframe with the proteins per reaction etc, as soon as overlap list and uniprotids has been made into a dataframe.\n",
    "overlap_2 = []\n",
    "\n",
    "for i in range(0,8036):\n",
    "    overlap_2.append(set(model_ids_3.iloc[i,:]).intersection(final_overlap))\n",
    "    continue\n",
    "    \n",
    "overlapdf = pd.DataFrame(overlap_2)\n",
    "\n",
    "overlapdf"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 206,
   "id": "harmful-arbor",
   "metadata": {
    "scrolled": true
   },
   "outputs": [
    {
     "data": {
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       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
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       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>0</th>\n",
       "      <th>1</th>\n",
       "      <th>2</th>\n",
       "      <th>3</th>\n",
       "      <th>4</th>\n",
       "      <th>5</th>\n",
       "      <th>6</th>\n",
       "      <th>7</th>\n",
       "      <th>8</th>\n",
       "      <th>9</th>\n",
       "      <th>...</th>\n",
       "      <th>56</th>\n",
       "      <th>57</th>\n",
       "      <th>58</th>\n",
       "      <th>59</th>\n",
       "      <th>60</th>\n",
       "      <th>61</th>\n",
       "      <th>62</th>\n",
       "      <th>63</th>\n",
       "      <th>ReactionID</th>\n",
       "      <th>ReactionRule</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>PTGR3_HUMAN</td>\n",
       "      <td>ADH7_HUMAN</td>\n",
       "      <td>ADHX_HUMAN</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>HMR_3905</td>\n",
       "      <td>Q8IWW8 or P28332 or Q8N4Q0 or P07327 or P40394...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>AK1A1_HUMAN</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>HMR_3907</td>\n",
       "      <td>P14550</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>HMR_4097</td>\n",
       "      <td>Q9NR19</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>HMR_4099</td>\n",
       "      <td>Q9H6R3 or Q9NUB1</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>HMR_4108</td>\n",
       "      <td>Q9NR19</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>...</th>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8031</th>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>HMR_10119</td>\n",
       "      <td>Q14973</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8032</th>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>HMR_10120</td>\n",
       "      <td>Q14973</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8033</th>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>HMR_10125</td>\n",
       "      <td>O95342 or O15438</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8034</th>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>HMR_10126</td>\n",
       "      <td>O95342 or O15438</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8035</th>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>HMR_10127</td>\n",
       "      <td>Q14973</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>8036 rows × 66 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "                0           1           2     3     4     5     6     7     8  \\\n",
       "0     PTGR3_HUMAN  ADH7_HUMAN  ADHX_HUMAN  None  None  None  None  None  None   \n",
       "1     AK1A1_HUMAN        None        None  None  None  None  None  None  None   \n",
       "2            None        None        None  None  None  None  None  None  None   \n",
       "3            None        None        None  None  None  None  None  None  None   \n",
       "4            None        None        None  None  None  None  None  None  None   \n",
       "...           ...         ...         ...   ...   ...   ...   ...   ...   ...   \n",
       "8031         None        None        None  None  None  None  None  None  None   \n",
       "8032         None        None        None  None  None  None  None  None  None   \n",
       "8033         None        None        None  None  None  None  None  None  None   \n",
       "8034         None        None        None  None  None  None  None  None  None   \n",
       "8035         None        None        None  None  None  None  None  None  None   \n",
       "\n",
       "         9  ...    56    57    58    59    60    61    62    63 ReactionID  \\\n",
       "0     None  ...  None  None  None  None  None  None  None  None   HMR_3905   \n",
       "1     None  ...  None  None  None  None  None  None  None  None   HMR_3907   \n",
       "2     None  ...  None  None  None  None  None  None  None  None   HMR_4097   \n",
       "3     None  ...  None  None  None  None  None  None  None  None   HMR_4099   \n",
       "4     None  ...  None  None  None  None  None  None  None  None   HMR_4108   \n",
       "...    ...  ...   ...   ...   ...   ...   ...   ...   ...   ...        ...   \n",
       "8031  None  ...  None  None  None  None  None  None  None  None  HMR_10119   \n",
       "8032  None  ...  None  None  None  None  None  None  None  None  HMR_10120   \n",
       "8033  None  ...  None  None  None  None  None  None  None  None  HMR_10125   \n",
       "8034  None  ...  None  None  None  None  None  None  None  None  HMR_10126   \n",
       "8035  None  ...  None  None  None  None  None  None  None  None  HMR_10127   \n",
       "\n",
       "                                           ReactionRule  \n",
       "0     Q8IWW8 or P28332 or Q8N4Q0 or P07327 or P40394...  \n",
       "1                                                P14550  \n",
       "2                                                Q9NR19  \n",
       "3                                      Q9H6R3 or Q9NUB1  \n",
       "4                                                Q9NR19  \n",
       "...                                                 ...  \n",
       "8031                                             Q14973  \n",
       "8032                                             Q14973  \n",
       "8033                                   O95342 or O15438  \n",
       "8034                                   O95342 or O15438  \n",
       "8035                                             Q14973  \n",
       "\n",
       "[8036 rows x 66 columns]"
      ]
     },
     "execution_count": 206,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "overlapdf['ReactionID'] = ReactionID\n",
    "overlapdf['ReactionRule'] = ReactionRule\n",
    "overlapdf"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 180,
   "id": "authentic-mailing",
   "metadata": {},
   "outputs": [],
   "source": [
    "#Saving overlap to CSV for overview.\n",
    "overlapdf.to_csv(r'/Users/katemeeson/Desktop/16062021.csv', index = False, header=True)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 208,
   "id": "proved-lucas",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "0       PTGR3_HUMAN\n",
       "1       AK1A1_HUMAN\n",
       "2               NaN\n",
       "3               NaN\n",
       "4               NaN\n",
       "           ...     \n",
       "8031            NaN\n",
       "8032            NaN\n",
       "8033            NaN\n",
       "8034            NaN\n",
       "8035            NaN\n",
       "Name: First_column, Length: 8036, dtype: object"
      ]
     },
     "execution_count": 208,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "overlap_df_2 = pd.read_csv(r'/Users/katemeeson/Desktop/16062021.csv')\n",
    "overlap_df_2['First_column'] #Renamed first column so I can search it and remove Nans."
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 213,
   "id": "civic-genealogy",
   "metadata": {
    "scrolled": true
   },
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>First_column</th>\n",
       "      <th>1</th>\n",
       "      <th>2</th>\n",
       "      <th>3</th>\n",
       "      <th>4</th>\n",
       "      <th>5</th>\n",
       "      <th>6</th>\n",
       "      <th>7</th>\n",
       "      <th>8</th>\n",
       "      <th>9</th>\n",
       "      <th>...</th>\n",
       "      <th>56</th>\n",
       "      <th>57</th>\n",
       "      <th>58</th>\n",
       "      <th>59</th>\n",
       "      <th>60</th>\n",
       "      <th>61</th>\n",
       "      <th>62</th>\n",
       "      <th>63</th>\n",
       "      <th>ReactionID</th>\n",
       "      <th>ReactionRule</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>PTGR3_HUMAN</td>\n",
       "      <td>ADH7_HUMAN</td>\n",
       "      <td>ADHX_HUMAN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>HMR_3905</td>\n",
       "      <td>Q8IWW8 or P28332 or Q8N4Q0 or P07327 or P40394...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>AK1A1_HUMAN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>HMR_3907</td>\n",
       "      <td>P14550</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>6</th>\n",
       "      <td>DLDH_HUMAN</td>\n",
       "      <td>ODP2_HUMAN</td>\n",
       "      <td>ODPA_HUMAN</td>\n",
       "      <td>ODPB_HUMAN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>HMR_4137</td>\n",
       "      <td>P09622 and O00330 and P08559 and P10515 and P2...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>7</th>\n",
       "      <td>LDH6A_HUMAN</td>\n",
       "      <td>LDHC_HUMAN</td>\n",
       "      <td>LDHB_HUMAN</td>\n",
       "      <td>LDHA_HUMAN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>HMR_4281</td>\n",
       "      <td>P07195 or P00338 or Q8IX04 or P07864 or Q6ZMR3...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8</th>\n",
       "      <td>LDH6A_HUMAN</td>\n",
       "      <td>LDHC_HUMAN</td>\n",
       "      <td>LDHB_HUMAN</td>\n",
       "      <td>LDHA_HUMAN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>HMR_4388</td>\n",
       "      <td>P07195 or P00338 or Q8IX04 or P07864 or Q6ZMR3...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>...</th>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>7915</th>\n",
       "      <td>MOT1_HUMAN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>ATVACIDMCTtu</td>\n",
       "      <td>P53985</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>7939</th>\n",
       "      <td>DHB4_HUMAN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>DEOXFVShc</td>\n",
       "      <td>P09110 or Q08426 or P51659 or Q15067</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>7980</th>\n",
       "      <td>DHB4_HUMAN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>PROFVSCOAhc</td>\n",
       "      <td>P09110 or Q08426 or P51659 or P11712 or Q15067</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8008</th>\n",
       "      <td>MPCP_HUMAN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>PIt2mi</td>\n",
       "      <td>Q00325</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8010</th>\n",
       "      <td>COX6C_HUMAN</td>\n",
       "      <td>COX41_HUMAN</td>\n",
       "      <td>CX6B1_HUMAN</td>\n",
       "      <td>COX2_HUMAN</td>\n",
       "      <td>COX5B_HUMAN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>CYOOm3i</td>\n",
       "      <td>P12074 and H0UI06 and P14854 and P15954 and Q9...</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>3017 rows × 66 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "     First_column            1            2           3            4    5  \\\n",
       "0     PTGR3_HUMAN   ADH7_HUMAN   ADHX_HUMAN         NaN          NaN  NaN   \n",
       "1     AK1A1_HUMAN          NaN          NaN         NaN          NaN  NaN   \n",
       "6      DLDH_HUMAN   ODP2_HUMAN   ODPA_HUMAN  ODPB_HUMAN          NaN  NaN   \n",
       "7     LDH6A_HUMAN   LDHC_HUMAN   LDHB_HUMAN  LDHA_HUMAN          NaN  NaN   \n",
       "8     LDH6A_HUMAN   LDHC_HUMAN   LDHB_HUMAN  LDHA_HUMAN          NaN  NaN   \n",
       "...           ...          ...          ...         ...          ...  ...   \n",
       "7915   MOT1_HUMAN          NaN          NaN         NaN          NaN  NaN   \n",
       "7939   DHB4_HUMAN          NaN          NaN         NaN          NaN  NaN   \n",
       "7980   DHB4_HUMAN          NaN          NaN         NaN          NaN  NaN   \n",
       "8008   MPCP_HUMAN          NaN          NaN         NaN          NaN  NaN   \n",
       "8010  COX6C_HUMAN  COX41_HUMAN  CX6B1_HUMAN  COX2_HUMAN  COX5B_HUMAN  NaN   \n",
       "\n",
       "        6    7    8    9  ...   56   57   58   59   60   61   62   63  \\\n",
       "0     NaN  NaN  NaN  NaN  ...  NaN  NaN  NaN  NaN  NaN  NaN  NaN  NaN   \n",
       "1     NaN  NaN  NaN  NaN  ...  NaN  NaN  NaN  NaN  NaN  NaN  NaN  NaN   \n",
       "6     NaN  NaN  NaN  NaN  ...  NaN  NaN  NaN  NaN  NaN  NaN  NaN  NaN   \n",
       "7     NaN  NaN  NaN  NaN  ...  NaN  NaN  NaN  NaN  NaN  NaN  NaN  NaN   \n",
       "8     NaN  NaN  NaN  NaN  ...  NaN  NaN  NaN  NaN  NaN  NaN  NaN  NaN   \n",
       "...   ...  ...  ...  ...  ...  ...  ...  ...  ...  ...  ...  ...  ...   \n",
       "7915  NaN  NaN  NaN  NaN  ...  NaN  NaN  NaN  NaN  NaN  NaN  NaN  NaN   \n",
       "7939  NaN  NaN  NaN  NaN  ...  NaN  NaN  NaN  NaN  NaN  NaN  NaN  NaN   \n",
       "7980  NaN  NaN  NaN  NaN  ...  NaN  NaN  NaN  NaN  NaN  NaN  NaN  NaN   \n",
       "8008  NaN  NaN  NaN  NaN  ...  NaN  NaN  NaN  NaN  NaN  NaN  NaN  NaN   \n",
       "8010  NaN  NaN  NaN  NaN  ...  NaN  NaN  NaN  NaN  NaN  NaN  NaN  NaN   \n",
       "\n",
       "        ReactionID                                       ReactionRule  \n",
       "0         HMR_3905  Q8IWW8 or P28332 or Q8N4Q0 or P07327 or P40394...  \n",
       "1         HMR_3907                                             P14550  \n",
       "6         HMR_4137  P09622 and O00330 and P08559 and P10515 and P2...  \n",
       "7         HMR_4281  P07195 or P00338 or Q8IX04 or P07864 or Q6ZMR3...  \n",
       "8         HMR_4388  P07195 or P00338 or Q8IX04 or P07864 or Q6ZMR3...  \n",
       "...            ...                                                ...  \n",
       "7915  ATVACIDMCTtu                                             P53985  \n",
       "7939     DEOXFVShc               P09110 or Q08426 or P51659 or Q15067  \n",
       "7980   PROFVSCOAhc     P09110 or Q08426 or P51659 or P11712 or Q15067  \n",
       "8008        PIt2mi                                             Q00325  \n",
       "8010       CYOOm3i  P12074 and H0UI06 and P14854 and P15954 and Q9...  \n",
       "\n",
       "[3017 rows x 66 columns]"
      ]
     },
     "execution_count": 213,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "#Remove reactions where there are no proteins we can annotate, and save file.\n",
    "overlap_df_2.dropna(subset = [\"First_column\"], inplace=True)\n",
    "overlap_df_2.to_csv(r'/Users/katemeeson/Desktop/160620212.csv', index = False, header=True)\n",
    "overlap_df_2 #This file contains all the reactions for which there is one essential protein in our dataset. Doesn't mean reaction rule is satisfied."
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 318,
   "id": "operational-thanks",
   "metadata": {},
   "outputs": [
    {
     "data": {
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       "      <th></th>\n",
       "      <th>IDs</th>\n",
       "      <th>IDs.1</th>\n",
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       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>2AAA_HUMAN</td>\n",
       "      <td>P30153</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>2AAB_HUMAN</td>\n",
       "      <td>P30154</td>\n",
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       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>3HIDH_HUMAN</td>\n",
       "      <td>P31937</td>\n",
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       "    <tr>\n",
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       "      <td>4EBP3_HUMAN</td>\n",
       "      <td>O60516</td>\n",
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       "    <tr>\n",
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       "      <td>...</td>\n",
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       "      <td>XPO7_HUMAN</td>\n",
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       "      <th>710</th>\n",
       "      <td>XYLT1_HUMAN</td>\n",
       "      <td>Q86Y38</td>\n",
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       "      <td>Q9H1B5</td>\n",
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       "      <td>YES_HUMAN</td>\n",
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       "      <td>ZCCHV_HUMAN</td>\n",
       "      <td>Q7Z2W4</td>\n",
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       "</table>\n",
       "<p>714 rows × 2 columns</p>\n",
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      ],
      "text/plain": [
       "             IDs   IDs.1\n",
       "0     2AAA_HUMAN  P30153\n",
       "1     2AAB_HUMAN  P30154\n",
       "2    3HIDH_HUMAN  P31937\n",
       "3    4EBP3_HUMAN  O60516\n",
       "4      4F2_HUMAN  P08195\n",
       "..           ...     ...\n",
       "709   XPO7_HUMAN  Q9UIA9\n",
       "710  XYLT1_HUMAN  Q86Y38\n",
       "711  XYLT2_HUMAN  Q9H1B5\n",
       "712    YES_HUMAN  P07947\n",
       "713  ZCCHV_HUMAN  Q7Z2W4\n",
       "\n",
       "[714 rows x 2 columns]"
      ]
     },
     "execution_count": 318,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "#CSV with Uniprot IDs (as well as protien names from overlap), so we can compare to reaction rules.\n",
    "overlap_uniprot_ids = pd.read_csv(r'/Users/katemeeson/Desktop/160620213.csv')\n",
    "overlap_uniprot_ids"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 319,
   "id": "measured-architecture",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "0      P30153\n",
       "1      P30154\n",
       "2      P31937\n",
       "3      O60516\n",
       "4      P08195\n",
       "        ...  \n",
       "709    Q9UIA9\n",
       "710    Q86Y38\n",
       "711    Q9H1B5\n",
       "712    P07947\n",
       "713    Q7Z2W4\n",
       "Name: IDs.1, Length: 714, dtype: object"
      ]
     },
     "execution_count": 319,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "#Creating variable for UniprotID column, ready for comparison.\n",
    "overlap_uniprot_ids_2 = overlap_uniprot_ids.iloc[:,1]\n",
    "overlap_uniprot_ids_2"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 320,
   "id": "coordinated-distribution",
   "metadata": {},
   "outputs": [
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       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8033</th>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
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       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
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       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
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       "      <td>None</td>\n",
       "      <td>None</td>\n",
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       "    <tr>\n",
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       "      <td>None</td>\n",
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       "<p>8036 rows × 64 columns</p>\n",
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      ],
      "text/plain": [
       "               0           1           2     3     4     5     6     7     8   \\\n",
       "0     PTGR3_HUMAN  ADH7_HUMAN  ADHX_HUMAN  None  None  None  None  None  None   \n",
       "1     AK1A1_HUMAN        None        None  None  None  None  None  None  None   \n",
       "2            None        None        None  None  None  None  None  None  None   \n",
       "3            None        None        None  None  None  None  None  None  None   \n",
       "4            None        None        None  None  None  None  None  None  None   \n",
       "...           ...         ...         ...   ...   ...   ...   ...   ...   ...   \n",
       "8031         None        None        None  None  None  None  None  None  None   \n",
       "8032         None        None        None  None  None  None  None  None  None   \n",
       "8033         None        None        None  None  None  None  None  None  None   \n",
       "8034         None        None        None  None  None  None  None  None  None   \n",
       "8035         None        None        None  None  None  None  None  None  None   \n",
       "\n",
       "        9   ...    54    55    56    57    58    59    60    61    62    63  \n",
       "0     None  ...  None  None  None  None  None  None  None  None  None  None  \n",
       "1     None  ...  None  None  None  None  None  None  None  None  None  None  \n",
       "2     None  ...  None  None  None  None  None  None  None  None  None  None  \n",
       "3     None  ...  None  None  None  None  None  None  None  None  None  None  \n",
       "4     None  ...  None  None  None  None  None  None  None  None  None  None  \n",
       "...    ...  ...   ...   ...   ...   ...   ...   ...   ...   ...   ...   ...  \n",
       "8031  None  ...  None  None  None  None  None  None  None  None  None  None  \n",
       "8032  None  ...  None  None  None  None  None  None  None  None  None  None  \n",
       "8033  None  ...  None  None  None  None  None  None  None  None  None  None  \n",
       "8034  None  ...  None  None  None  None  None  None  None  None  None  None  \n",
       "8035  None  ...  None  None  None  None  None  None  None  None  None  None  \n",
       "\n",
       "[8036 rows x 64 columns]"
      ]
     },
     "execution_count": 320,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "#Use this to create overlap dataframe with the proteins per reaction etc, as soon as overlap list and uniprotids has been made into a dataframe.\n",
    "overlap_2 = []\n",
    "\n",
    "for i in range(0,8036):\n",
    "    overlap_2.append(set(model_ids_3.iloc[i,:]).intersection(final_overlap))\n",
    "    continue\n",
    "    \n",
    "overlapdf = pd.DataFrame(overlap_2)\n",
    "\n",
    "overlapdf #df shows proteins from our dataset for each reaction, which are mentioned in the reaction rule. "
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 321,
   "id": "crude-funds",
   "metadata": {},
   "outputs": [
    {
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       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>HMR_3905</td>\n",
       "      <td>Q8IWW8 or P28332 or Q8N4Q0 or P07327 or P40394...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>AK1A1_HUMAN</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>HMR_3907</td>\n",
       "      <td>P14550</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>HMR_4097</td>\n",
       "      <td>Q9NR19</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>HMR_4099</td>\n",
       "      <td>Q9H6R3 or Q9NUB1</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>HMR_4108</td>\n",
       "      <td>Q9NR19</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>...</th>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8031</th>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>HMR_10119</td>\n",
       "      <td>Q14973</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8032</th>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>HMR_10120</td>\n",
       "      <td>Q14973</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8033</th>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>HMR_10125</td>\n",
       "      <td>O95342 or O15438</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8034</th>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>HMR_10126</td>\n",
       "      <td>O95342 or O15438</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8035</th>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>HMR_10127</td>\n",
       "      <td>Q14973</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>8036 rows × 66 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "                0           1           2     3     4     5     6     7     8  \\\n",
       "0     PTGR3_HUMAN  ADH7_HUMAN  ADHX_HUMAN  None  None  None  None  None  None   \n",
       "1     AK1A1_HUMAN        None        None  None  None  None  None  None  None   \n",
       "2            None        None        None  None  None  None  None  None  None   \n",
       "3            None        None        None  None  None  None  None  None  None   \n",
       "4            None        None        None  None  None  None  None  None  None   \n",
       "...           ...         ...         ...   ...   ...   ...   ...   ...   ...   \n",
       "8031         None        None        None  None  None  None  None  None  None   \n",
       "8032         None        None        None  None  None  None  None  None  None   \n",
       "8033         None        None        None  None  None  None  None  None  None   \n",
       "8034         None        None        None  None  None  None  None  None  None   \n",
       "8035         None        None        None  None  None  None  None  None  None   \n",
       "\n",
       "         9  ...    56    57    58    59    60    61    62    63 ReactionID  \\\n",
       "0     None  ...  None  None  None  None  None  None  None  None   HMR_3905   \n",
       "1     None  ...  None  None  None  None  None  None  None  None   HMR_3907   \n",
       "2     None  ...  None  None  None  None  None  None  None  None   HMR_4097   \n",
       "3     None  ...  None  None  None  None  None  None  None  None   HMR_4099   \n",
       "4     None  ...  None  None  None  None  None  None  None  None   HMR_4108   \n",
       "...    ...  ...   ...   ...   ...   ...   ...   ...   ...   ...        ...   \n",
       "8031  None  ...  None  None  None  None  None  None  None  None  HMR_10119   \n",
       "8032  None  ...  None  None  None  None  None  None  None  None  HMR_10120   \n",
       "8033  None  ...  None  None  None  None  None  None  None  None  HMR_10125   \n",
       "8034  None  ...  None  None  None  None  None  None  None  None  HMR_10126   \n",
       "8035  None  ...  None  None  None  None  None  None  None  None  HMR_10127   \n",
       "\n",
       "                                           ReactionRule  \n",
       "0     Q8IWW8 or P28332 or Q8N4Q0 or P07327 or P40394...  \n",
       "1                                                P14550  \n",
       "2                                                Q9NR19  \n",
       "3                                      Q9H6R3 or Q9NUB1  \n",
       "4                                                Q9NR19  \n",
       "...                                                 ...  \n",
       "8031                                             Q14973  \n",
       "8032                                             Q14973  \n",
       "8033                                   O95342 or O15438  \n",
       "8034                                   O95342 or O15438  \n",
       "8035                                             Q14973  \n",
       "\n",
       "[8036 rows x 66 columns]"
      ]
     },
     "execution_count": 321,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "overlapdf['ReactionID'] = ReactionID\n",
    "overlapdf['ReactionRule'] = ReactionRule\n",
    "overlapdf #Added reaction rules and IDs to the df. This df contains Nans. "
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 322,
   "id": "deadly-month",
   "metadata": {},
   "outputs": [],
   "source": [
    "#Saving overlap to CSV for overview.\n",
    "overlapdf.to_csv(r'/Users/katemeeson/Desktop/16062021.csv', index = False, header=True)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 325,
   "id": "broken-lender",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "0       PTGR3_HUMAN\n",
       "1       AK1A1_HUMAN\n",
       "2               NaN\n",
       "3               NaN\n",
       "4               NaN\n",
       "           ...     \n",
       "8031            NaN\n",
       "8032            NaN\n",
       "8033            NaN\n",
       "8034            NaN\n",
       "8035            NaN\n",
       "Name: First_column, Length: 8036, dtype: object"
      ]
     },
     "execution_count": 325,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "overlap_df_2 = pd.read_csv(r'/Users/katemeeson/Desktop/16062021.csv')\n",
    "overlap_df_2['First_column'] #Renamed first column so I can search it and remove Nans."
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 326,
   "id": "conceptual-nicholas",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>First_column</th>\n",
       "      <th>1</th>\n",
       "      <th>2</th>\n",
       "      <th>3</th>\n",
       "      <th>4</th>\n",
       "      <th>5</th>\n",
       "      <th>6</th>\n",
       "      <th>7</th>\n",
       "      <th>8</th>\n",
       "      <th>9</th>\n",
       "      <th>...</th>\n",
       "      <th>56</th>\n",
       "      <th>57</th>\n",
       "      <th>58</th>\n",
       "      <th>59</th>\n",
       "      <th>60</th>\n",
       "      <th>61</th>\n",
       "      <th>62</th>\n",
       "      <th>63</th>\n",
       "      <th>ReactionID</th>\n",
       "      <th>ReactionRule</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>PTGR3_HUMAN</td>\n",
       "      <td>ADH7_HUMAN</td>\n",
       "      <td>ADHX_HUMAN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>HMR_3905</td>\n",
       "      <td>Q8IWW8 or P28332 or Q8N4Q0 or P07327 or P40394...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>AK1A1_HUMAN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>HMR_3907</td>\n",
       "      <td>P14550</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>6</th>\n",
       "      <td>DLDH_HUMAN</td>\n",
       "      <td>ODP2_HUMAN</td>\n",
       "      <td>ODPA_HUMAN</td>\n",
       "      <td>ODPB_HUMAN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>HMR_4137</td>\n",
       "      <td>P09622 and O00330 and P08559 and P10515 and P2...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>7</th>\n",
       "      <td>LDH6A_HUMAN</td>\n",
       "      <td>LDHC_HUMAN</td>\n",
       "      <td>LDHB_HUMAN</td>\n",
       "      <td>LDHA_HUMAN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>HMR_4281</td>\n",
       "      <td>P07195 or P00338 or Q8IX04 or P07864 or Q6ZMR3...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8</th>\n",
       "      <td>LDH6A_HUMAN</td>\n",
       "      <td>LDHC_HUMAN</td>\n",
       "      <td>LDHB_HUMAN</td>\n",
       "      <td>LDHA_HUMAN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>HMR_4388</td>\n",
       "      <td>P07195 or P00338 or Q8IX04 or P07864 or Q6ZMR3...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>...</th>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>7915</th>\n",
       "      <td>MOT1_HUMAN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>ATVACIDMCTtu</td>\n",
       "      <td>P53985</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>7939</th>\n",
       "      <td>DHB4_HUMAN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>DEOXFVShc</td>\n",
       "      <td>P09110 or Q08426 or P51659 or Q15067</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>7980</th>\n",
       "      <td>DHB4_HUMAN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>PROFVSCOAhc</td>\n",
       "      <td>P09110 or Q08426 or P51659 or P11712 or Q15067</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8008</th>\n",
       "      <td>MPCP_HUMAN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>PIt2mi</td>\n",
       "      <td>Q00325</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8010</th>\n",
       "      <td>COX6C_HUMAN</td>\n",
       "      <td>COX41_HUMAN</td>\n",
       "      <td>CX6B1_HUMAN</td>\n",
       "      <td>COX2_HUMAN</td>\n",
       "      <td>COX5B_HUMAN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>CYOOm3i</td>\n",
       "      <td>P12074 and H0UI06 and P14854 and P15954 and Q9...</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>3017 rows × 66 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "     First_column            1            2           3            4    5  \\\n",
       "0     PTGR3_HUMAN   ADH7_HUMAN   ADHX_HUMAN         NaN          NaN  NaN   \n",
       "1     AK1A1_HUMAN          NaN          NaN         NaN          NaN  NaN   \n",
       "6      DLDH_HUMAN   ODP2_HUMAN   ODPA_HUMAN  ODPB_HUMAN          NaN  NaN   \n",
       "7     LDH6A_HUMAN   LDHC_HUMAN   LDHB_HUMAN  LDHA_HUMAN          NaN  NaN   \n",
       "8     LDH6A_HUMAN   LDHC_HUMAN   LDHB_HUMAN  LDHA_HUMAN          NaN  NaN   \n",
       "...           ...          ...          ...         ...          ...  ...   \n",
       "7915   MOT1_HUMAN          NaN          NaN         NaN          NaN  NaN   \n",
       "7939   DHB4_HUMAN          NaN          NaN         NaN          NaN  NaN   \n",
       "7980   DHB4_HUMAN          NaN          NaN         NaN          NaN  NaN   \n",
       "8008   MPCP_HUMAN          NaN          NaN         NaN          NaN  NaN   \n",
       "8010  COX6C_HUMAN  COX41_HUMAN  CX6B1_HUMAN  COX2_HUMAN  COX5B_HUMAN  NaN   \n",
       "\n",
       "        6    7    8    9  ...   56   57   58   59   60   61   62   63  \\\n",
       "0     NaN  NaN  NaN  NaN  ...  NaN  NaN  NaN  NaN  NaN  NaN  NaN  NaN   \n",
       "1     NaN  NaN  NaN  NaN  ...  NaN  NaN  NaN  NaN  NaN  NaN  NaN  NaN   \n",
       "6     NaN  NaN  NaN  NaN  ...  NaN  NaN  NaN  NaN  NaN  NaN  NaN  NaN   \n",
       "7     NaN  NaN  NaN  NaN  ...  NaN  NaN  NaN  NaN  NaN  NaN  NaN  NaN   \n",
       "8     NaN  NaN  NaN  NaN  ...  NaN  NaN  NaN  NaN  NaN  NaN  NaN  NaN   \n",
       "...   ...  ...  ...  ...  ...  ...  ...  ...  ...  ...  ...  ...  ...   \n",
       "7915  NaN  NaN  NaN  NaN  ...  NaN  NaN  NaN  NaN  NaN  NaN  NaN  NaN   \n",
       "7939  NaN  NaN  NaN  NaN  ...  NaN  NaN  NaN  NaN  NaN  NaN  NaN  NaN   \n",
       "7980  NaN  NaN  NaN  NaN  ...  NaN  NaN  NaN  NaN  NaN  NaN  NaN  NaN   \n",
       "8008  NaN  NaN  NaN  NaN  ...  NaN  NaN  NaN  NaN  NaN  NaN  NaN  NaN   \n",
       "8010  NaN  NaN  NaN  NaN  ...  NaN  NaN  NaN  NaN  NaN  NaN  NaN  NaN   \n",
       "\n",
       "        ReactionID                                       ReactionRule  \n",
       "0         HMR_3905  Q8IWW8 or P28332 or Q8N4Q0 or P07327 or P40394...  \n",
       "1         HMR_3907                                             P14550  \n",
       "6         HMR_4137  P09622 and O00330 and P08559 and P10515 and P2...  \n",
       "7         HMR_4281  P07195 or P00338 or Q8IX04 or P07864 or Q6ZMR3...  \n",
       "8         HMR_4388  P07195 or P00338 or Q8IX04 or P07864 or Q6ZMR3...  \n",
       "...            ...                                                ...  \n",
       "7915  ATVACIDMCTtu                                             P53985  \n",
       "7939     DEOXFVShc               P09110 or Q08426 or P51659 or Q15067  \n",
       "7980   PROFVSCOAhc     P09110 or Q08426 or P51659 or P11712 or Q15067  \n",
       "8008        PIt2mi                                             Q00325  \n",
       "8010       CYOOm3i  P12074 and H0UI06 and P14854 and P15954 and Q9...  \n",
       "\n",
       "[3017 rows x 66 columns]"
      ]
     },
     "execution_count": 326,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "#Remove reactions where there are no proteins we can annotate, and save file.\n",
    "overlap_df_2.dropna(subset = [\"First_column\"], inplace=True)\n",
    "overlap_df_2.to_csv(r'/Users/katemeeson/Desktop/160620212.csv', index = False, header=True)\n",
    "overlap_df_2"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 327,
   "id": "interesting-temple",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>0</th>\n",
       "      <th>1</th>\n",
       "      <th>2</th>\n",
       "      <th>3</th>\n",
       "      <th>4</th>\n",
       "      <th>5</th>\n",
       "      <th>6</th>\n",
       "      <th>7</th>\n",
       "      <th>8</th>\n",
       "      <th>9</th>\n",
       "      <th>...</th>\n",
       "      <th>343</th>\n",
       "      <th>344</th>\n",
       "      <th>345</th>\n",
       "      <th>346</th>\n",
       "      <th>347</th>\n",
       "      <th>348</th>\n",
       "      <th>349</th>\n",
       "      <th>350</th>\n",
       "      <th>ReactionID</th>\n",
       "      <th>ReactionRule</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>HOT_HUMAN</td>\n",
       "      <td>ADH1G_HUMAN</td>\n",
       "      <td>ADHX_HUMAN</td>\n",
       "      <td>PTGR3_HUMAN</td>\n",
       "      <td>ADH1B_HUMAN</td>\n",
       "      <td>ADH1A_HUMAN</td>\n",
       "      <td>ADH6_HUMAN</td>\n",
       "      <td>ADH7_HUMAN</td>\n",
       "      <td>ADH4_HUMAN</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>HMR_3905</td>\n",
       "      <td>Q8IWW8 or P28332 or Q8N4Q0 or P07327 or P40394...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>AK1A1_HUMAN</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>HMR_3907</td>\n",
       "      <td>P14550</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>ACSA_HUMAN</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>HMR_4097</td>\n",
       "      <td>Q9NR19</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>ACS2L_HUMAN</td>\n",
       "      <td>ACSS3_HUMAN</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>HMR_4099</td>\n",
       "      <td>Q9H6R3 or Q9NUB1</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>ACSA_HUMAN</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>HMR_4108</td>\n",
       "      <td>Q9NR19</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>...</th>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>13082</th>\n",
       "      <td>NTCP_HUMAN</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>HMR_10119</td>\n",
       "      <td>Q14973</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>13083</th>\n",
       "      <td>NTCP_HUMAN</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>HMR_10120</td>\n",
       "      <td>Q14973</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>13088</th>\n",
       "      <td>MRP3_HUMAN</td>\n",
       "      <td>ABCBB_HUMAN</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>HMR_10125</td>\n",
       "      <td>O95342 or O15438</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>13089</th>\n",
       "      <td>MRP3_HUMAN</td>\n",
       "      <td>ABCBB_HUMAN</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>HMR_10126</td>\n",
       "      <td>O95342 or O15438</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>13090</th>\n",
       "      <td>NTCP_HUMAN</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>HMR_10127</td>\n",
       "      <td>Q14973</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>8036 rows × 353 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "                 0            1           2            3            4  \\\n",
       "0        HOT_HUMAN  ADH1G_HUMAN  ADHX_HUMAN  PTGR3_HUMAN  ADH1B_HUMAN   \n",
       "1      AK1A1_HUMAN         None        None         None         None   \n",
       "2       ACSA_HUMAN         None        None         None         None   \n",
       "3      ACS2L_HUMAN  ACSS3_HUMAN        None         None         None   \n",
       "4       ACSA_HUMAN         None        None         None         None   \n",
       "...            ...          ...         ...          ...          ...   \n",
       "13082   NTCP_HUMAN         None        None         None         None   \n",
       "13083   NTCP_HUMAN         None        None         None         None   \n",
       "13088   MRP3_HUMAN  ABCBB_HUMAN        None         None         None   \n",
       "13089   MRP3_HUMAN  ABCBB_HUMAN        None         None         None   \n",
       "13090   NTCP_HUMAN         None        None         None         None   \n",
       "\n",
       "                 5           6           7           8     9  ...   343   344  \\\n",
       "0      ADH1A_HUMAN  ADH6_HUMAN  ADH7_HUMAN  ADH4_HUMAN  None  ...  None  None   \n",
       "1             None        None        None        None  None  ...  None  None   \n",
       "2             None        None        None        None  None  ...  None  None   \n",
       "3             None        None        None        None  None  ...  None  None   \n",
       "4             None        None        None        None  None  ...  None  None   \n",
       "...            ...         ...         ...         ...   ...  ...   ...   ...   \n",
       "13082         None        None        None        None  None  ...  None  None   \n",
       "13083         None        None        None        None  None  ...  None  None   \n",
       "13088         None        None        None        None  None  ...  None  None   \n",
       "13089         None        None        None        None  None  ...  None  None   \n",
       "13090         None        None        None        None  None  ...  None  None   \n",
       "\n",
       "        345   346   347   348   349   350 ReactionID  \\\n",
       "0      None  None  None  None  None  None   HMR_3905   \n",
       "1      None  None  None  None  None  None   HMR_3907   \n",
       "2      None  None  None  None  None  None   HMR_4097   \n",
       "3      None  None  None  None  None  None   HMR_4099   \n",
       "4      None  None  None  None  None  None   HMR_4108   \n",
       "...     ...   ...   ...   ...   ...   ...        ...   \n",
       "13082  None  None  None  None  None  None  HMR_10119   \n",
       "13083  None  None  None  None  None  None  HMR_10120   \n",
       "13088  None  None  None  None  None  None  HMR_10125   \n",
       "13089  None  None  None  None  None  None  HMR_10126   \n",
       "13090  None  None  None  None  None  None  HMR_10127   \n",
       "\n",
       "                                            ReactionRule  \n",
       "0      Q8IWW8 or P28332 or Q8N4Q0 or P07327 or P40394...  \n",
       "1                                                 P14550  \n",
       "2                                                 Q9NR19  \n",
       "3                                       Q9H6R3 or Q9NUB1  \n",
       "4                                                 Q9NR19  \n",
       "...                                                  ...  \n",
       "13082                                             Q14973  \n",
       "13083                                             Q14973  \n",
       "13088                                   O95342 or O15438  \n",
       "13089                                   O95342 or O15438  \n",
       "13090                                             Q14973  \n",
       "\n",
       "[8036 rows x 353 columns]"
      ]
     },
     "execution_count": 327,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "separated_ids['ReactionID'] = ReactionID\n",
    "separated_ids['ReactionRule'] = ReactionRule\n",
    "separated_ids"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 328,
   "id": "equivalent-wellington",
   "metadata": {},
   "outputs": [
    {
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      "text/plain": [
       "          0     1       2     3       4     5       6     7       8     9    \\\n",
       "0      Q8IWW8    or  P28332    or  Q8N4Q0    or  P07327    or  P40394    or   \n",
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       "3      Q9H6R3    or  Q9NUB1  None    None  None    None  None    None  None   \n",
       "4      Q9NR19  None    None  None    None  None    None  None    None  None   \n",
       "...       ...   ...     ...   ...     ...   ...     ...   ...     ...   ...   \n",
       "13082  Q14973  None    None  None    None  None    None  None    None  None   \n",
       "13083  Q14973  None    None  None    None  None    None  None    None  None   \n",
       "13088  O95342    or  O15438  None    None  None    None  None    None  None   \n",
       "13089  O95342    or  O15438  None    None  None    None  None    None  None   \n",
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       "\n",
       "       ...   707   708   709   710   711   712   713   714   715   716  \n",
       "0      ...  None  None  None  None  None  None  None  None  None  None  \n",
       "1      ...  None  None  None  None  None  None  None  None  None  None  \n",
       "2      ...  None  None  None  None  None  None  None  None  None  None  \n",
       "3      ...  None  None  None  None  None  None  None  None  None  None  \n",
       "4      ...  None  None  None  None  None  None  None  None  None  None  \n",
       "...    ...   ...   ...   ...   ...   ...   ...   ...   ...   ...   ...  \n",
       "13082  ...  None  None  None  None  None  None  None  None  None  None  \n",
       "13083  ...  None  None  None  None  None  None  None  None  None  None  \n",
       "13088  ...  None  None  None  None  None  None  None  None  None  None  \n",
       "13089  ...  None  None  None  None  None  None  None  None  None  None  \n",
       "13090  ...  None  None  None  None  None  None  None  None  None  None  \n",
       "\n",
       "[8036 rows x 717 columns]"
      ]
     },
     "execution_count": 328,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "Rules_split = model.ReactionRule.str.split(expand=True)\n",
    "Rules_split #Split rules so they can be searched against uniprot ids. "
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 329,
   "id": "neural-scheme",
   "metadata": {},
   "outputs": [
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       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>...</th>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8031</th>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8032</th>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8033</th>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8034</th>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8035</th>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>8036 rows × 64 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "          0       1       2     3     4     5     6     7     8     9   ...  \\\n",
       "0     P40394  Q8N4Q0  P11766  None  None  None  None  None  None  None  ...   \n",
       "1     P14550    None    None  None  None  None  None  None  None  None  ...   \n",
       "2       None    None    None  None  None  None  None  None  None  None  ...   \n",
       "3       None    None    None  None  None  None  None  None  None  None  ...   \n",
       "4       None    None    None  None  None  None  None  None  None  None  ...   \n",
       "...      ...     ...     ...   ...   ...   ...   ...   ...   ...   ...  ...   \n",
       "8031    None    None    None  None  None  None  None  None  None  None  ...   \n",
       "8032    None    None    None  None  None  None  None  None  None  None  ...   \n",
       "8033    None    None    None  None  None  None  None  None  None  None  ...   \n",
       "8034    None    None    None  None  None  None  None  None  None  None  ...   \n",
       "8035    None    None    None  None  None  None  None  None  None  None  ...   \n",
       "\n",
       "        54    55    56    57    58    59    60    61    62    63  \n",
       "0     None  None  None  None  None  None  None  None  None  None  \n",
       "1     None  None  None  None  None  None  None  None  None  None  \n",
       "2     None  None  None  None  None  None  None  None  None  None  \n",
       "3     None  None  None  None  None  None  None  None  None  None  \n",
       "4     None  None  None  None  None  None  None  None  None  None  \n",
       "...    ...   ...   ...   ...   ...   ...   ...   ...   ...   ...  \n",
       "8031  None  None  None  None  None  None  None  None  None  None  \n",
       "8032  None  None  None  None  None  None  None  None  None  None  \n",
       "8033  None  None  None  None  None  None  None  None  None  None  \n",
       "8034  None  None  None  None  None  None  None  None  None  None  \n",
       "8035  None  None  None  None  None  None  None  None  None  None  \n",
       "\n",
       "[8036 rows x 64 columns]"
      ]
     },
     "execution_count": 329,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "overlap_3 = []\n",
    "\n",
    "for i in range(0,8036):\n",
    "    overlap_3.append(set(Rules_split.iloc[i,:]).intersection(overlap_uniprot_ids_2))\n",
    "    continue\n",
    "    \n",
    "overlapdf2 = pd.DataFrame(overlap_3)\n",
    "\n",
    "overlapdf2 #df showing uniprot ids which are in the reaction rules. Contains Nans. "
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 330,
   "id": "looking-processor",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>0</th>\n",
       "      <th>1</th>\n",
       "      <th>2</th>\n",
       "      <th>3</th>\n",
       "      <th>4</th>\n",
       "      <th>5</th>\n",
       "      <th>6</th>\n",
       "      <th>7</th>\n",
       "      <th>8</th>\n",
       "      <th>9</th>\n",
       "      <th>...</th>\n",
       "      <th>56</th>\n",
       "      <th>57</th>\n",
       "      <th>58</th>\n",
       "      <th>59</th>\n",
       "      <th>60</th>\n",
       "      <th>61</th>\n",
       "      <th>62</th>\n",
       "      <th>63</th>\n",
       "      <th>ReactionID</th>\n",
       "      <th>ReactionRule</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>P40394</td>\n",
       "      <td>Q8N4Q0</td>\n",
       "      <td>P11766</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>HMR_3905</td>\n",
       "      <td>Q8IWW8 or P28332 or Q8N4Q0 or P07327 or P40394...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>P14550</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>HMR_3907</td>\n",
       "      <td>P14550</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>HMR_4097</td>\n",
       "      <td>Q9NR19</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>HMR_4099</td>\n",
       "      <td>Q9H6R3 or Q9NUB1</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>HMR_4108</td>\n",
       "      <td>Q9NR19</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>...</th>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8031</th>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>HMR_10119</td>\n",
       "      <td>Q14973</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8032</th>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>HMR_10120</td>\n",
       "      <td>Q14973</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8033</th>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>HMR_10125</td>\n",
       "      <td>O95342 or O15438</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8034</th>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>HMR_10126</td>\n",
       "      <td>O95342 or O15438</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8035</th>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>HMR_10127</td>\n",
       "      <td>Q14973</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>8036 rows × 66 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "           0       1       2     3     4     5     6     7     8     9  ...  \\\n",
       "0     P40394  Q8N4Q0  P11766  None  None  None  None  None  None  None  ...   \n",
       "1     P14550    None    None  None  None  None  None  None  None  None  ...   \n",
       "2       None    None    None  None  None  None  None  None  None  None  ...   \n",
       "3       None    None    None  None  None  None  None  None  None  None  ...   \n",
       "4       None    None    None  None  None  None  None  None  None  None  ...   \n",
       "...      ...     ...     ...   ...   ...   ...   ...   ...   ...   ...  ...   \n",
       "8031    None    None    None  None  None  None  None  None  None  None  ...   \n",
       "8032    None    None    None  None  None  None  None  None  None  None  ...   \n",
       "8033    None    None    None  None  None  None  None  None  None  None  ...   \n",
       "8034    None    None    None  None  None  None  None  None  None  None  ...   \n",
       "8035    None    None    None  None  None  None  None  None  None  None  ...   \n",
       "\n",
       "        56    57    58    59    60    61    62    63 ReactionID  \\\n",
       "0     None  None  None  None  None  None  None  None   HMR_3905   \n",
       "1     None  None  None  None  None  None  None  None   HMR_3907   \n",
       "2     None  None  None  None  None  None  None  None   HMR_4097   \n",
       "3     None  None  None  None  None  None  None  None   HMR_4099   \n",
       "4     None  None  None  None  None  None  None  None   HMR_4108   \n",
       "...    ...   ...   ...   ...   ...   ...   ...   ...        ...   \n",
       "8031  None  None  None  None  None  None  None  None  HMR_10119   \n",
       "8032  None  None  None  None  None  None  None  None  HMR_10120   \n",
       "8033  None  None  None  None  None  None  None  None  HMR_10125   \n",
       "8034  None  None  None  None  None  None  None  None  HMR_10126   \n",
       "8035  None  None  None  None  None  None  None  None  HMR_10127   \n",
       "\n",
       "                                           ReactionRule  \n",
       "0     Q8IWW8 or P28332 or Q8N4Q0 or P07327 or P40394...  \n",
       "1                                                P14550  \n",
       "2                                                Q9NR19  \n",
       "3                                      Q9H6R3 or Q9NUB1  \n",
       "4                                                Q9NR19  \n",
       "...                                                 ...  \n",
       "8031                                             Q14973  \n",
       "8032                                             Q14973  \n",
       "8033                                   O95342 or O15438  \n",
       "8034                                   O95342 or O15438  \n",
       "8035                                             Q14973  \n",
       "\n",
       "[8036 rows x 66 columns]"
      ]
     },
     "execution_count": 330,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "overlapdf2['ReactionID'] = ReactionID\n",
    "overlapdf2['ReactionRule'] = ReactionRule\n",
    "overlapdf2 #Adding reactin rules and IDs to df. "
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 331,
   "id": "apparent-willow",
   "metadata": {},
   "outputs": [],
   "source": [
    "overlapdf2.to_csv(r'/Users/katemeeson/Desktop/17062021.csv', index = False, header=True)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 333,
   "id": "rising-gasoline",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "0       P40394\n",
       "1       P14550\n",
       "2          NaN\n",
       "3          NaN\n",
       "4          NaN\n",
       "         ...  \n",
       "8031       NaN\n",
       "8032       NaN\n",
       "8033       NaN\n",
       "8034       NaN\n",
       "8035       NaN\n",
       "Name: First_column, Length: 8036, dtype: object"
      ]
     },
     "execution_count": 333,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "overlap_df_3 = pd.read_csv(r'/Users/katemeeson/Desktop/17062021.csv')\n",
    "overlap_df_3['First_column']"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 334,
   "id": "leading-butter",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
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       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>First_column</th>\n",
       "      <th>1</th>\n",
       "      <th>2</th>\n",
       "      <th>3</th>\n",
       "      <th>4</th>\n",
       "      <th>5</th>\n",
       "      <th>6</th>\n",
       "      <th>7</th>\n",
       "      <th>8</th>\n",
       "      <th>9</th>\n",
       "      <th>...</th>\n",
       "      <th>56</th>\n",
       "      <th>57</th>\n",
       "      <th>58</th>\n",
       "      <th>59</th>\n",
       "      <th>60</th>\n",
       "      <th>61</th>\n",
       "      <th>62</th>\n",
       "      <th>63</th>\n",
       "      <th>ReactionID</th>\n",
       "      <th>ReactionRule</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>P40394</td>\n",
       "      <td>Q8N4Q0</td>\n",
       "      <td>P11766</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>HMR_3905</td>\n",
       "      <td>Q8IWW8 or P28332 or Q8N4Q0 or P07327 or P40394...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>P14550</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>HMR_3907</td>\n",
       "      <td>P14550</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>6</th>\n",
       "      <td>P09622</td>\n",
       "      <td>P08559</td>\n",
       "      <td>P11177</td>\n",
       "      <td>P10515</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>HMR_4137</td>\n",
       "      <td>P09622 and O00330 and P08559 and P10515 and P2...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>7</th>\n",
       "      <td>P07195</td>\n",
       "      <td>Q6ZMR3</td>\n",
       "      <td>P07864</td>\n",
       "      <td>P00338</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>HMR_4281</td>\n",
       "      <td>P07195 or P00338 or Q8IX04 or P07864 or Q6ZMR3...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8</th>\n",
       "      <td>P07195</td>\n",
       "      <td>Q6ZMR3</td>\n",
       "      <td>P07864</td>\n",
       "      <td>P00338</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>HMR_4388</td>\n",
       "      <td>P07195 or P00338 or Q8IX04 or P07864 or Q6ZMR3...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>...</th>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>7915</th>\n",
       "      <td>P53985</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>ATVACIDMCTtu</td>\n",
       "      <td>P53985</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>7939</th>\n",
       "      <td>P51659</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>DEOXFVShc</td>\n",
       "      <td>P09110 or Q08426 or P51659 or Q15067</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>7980</th>\n",
       "      <td>P51659</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>PROFVSCOAhc</td>\n",
       "      <td>P09110 or Q08426 or P51659 or P11712 or Q15067</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8008</th>\n",
       "      <td>Q00325</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>PIt2mi</td>\n",
       "      <td>Q00325</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8010</th>\n",
       "      <td>P00403</td>\n",
       "      <td>P13073</td>\n",
       "      <td>P09669</td>\n",
       "      <td>P14854</td>\n",
       "      <td>P10606</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>CYOOm3i</td>\n",
       "      <td>P12074 and H0UI06 and P14854 and P15954 and Q9...</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>3017 rows × 66 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "     First_column       1       2       3       4    5    6    7    8    9  \\\n",
       "0          P40394  Q8N4Q0  P11766     NaN     NaN  NaN  NaN  NaN  NaN  NaN   \n",
       "1          P14550     NaN     NaN     NaN     NaN  NaN  NaN  NaN  NaN  NaN   \n",
       "6          P09622  P08559  P11177  P10515     NaN  NaN  NaN  NaN  NaN  NaN   \n",
       "7          P07195  Q6ZMR3  P07864  P00338     NaN  NaN  NaN  NaN  NaN  NaN   \n",
       "8          P07195  Q6ZMR3  P07864  P00338     NaN  NaN  NaN  NaN  NaN  NaN   \n",
       "...           ...     ...     ...     ...     ...  ...  ...  ...  ...  ...   \n",
       "7915       P53985     NaN     NaN     NaN     NaN  NaN  NaN  NaN  NaN  NaN   \n",
       "7939       P51659     NaN     NaN     NaN     NaN  NaN  NaN  NaN  NaN  NaN   \n",
       "7980       P51659     NaN     NaN     NaN     NaN  NaN  NaN  NaN  NaN  NaN   \n",
       "8008       Q00325     NaN     NaN     NaN     NaN  NaN  NaN  NaN  NaN  NaN   \n",
       "8010       P00403  P13073  P09669  P14854  P10606  NaN  NaN  NaN  NaN  NaN   \n",
       "\n",
       "      ...   56   57   58   59   60   61   62   63    ReactionID  \\\n",
       "0     ...  NaN  NaN  NaN  NaN  NaN  NaN  NaN  NaN      HMR_3905   \n",
       "1     ...  NaN  NaN  NaN  NaN  NaN  NaN  NaN  NaN      HMR_3907   \n",
       "6     ...  NaN  NaN  NaN  NaN  NaN  NaN  NaN  NaN      HMR_4137   \n",
       "7     ...  NaN  NaN  NaN  NaN  NaN  NaN  NaN  NaN      HMR_4281   \n",
       "8     ...  NaN  NaN  NaN  NaN  NaN  NaN  NaN  NaN      HMR_4388   \n",
       "...   ...  ...  ...  ...  ...  ...  ...  ...  ...           ...   \n",
       "7915  ...  NaN  NaN  NaN  NaN  NaN  NaN  NaN  NaN  ATVACIDMCTtu   \n",
       "7939  ...  NaN  NaN  NaN  NaN  NaN  NaN  NaN  NaN     DEOXFVShc   \n",
       "7980  ...  NaN  NaN  NaN  NaN  NaN  NaN  NaN  NaN   PROFVSCOAhc   \n",
       "8008  ...  NaN  NaN  NaN  NaN  NaN  NaN  NaN  NaN        PIt2mi   \n",
       "8010  ...  NaN  NaN  NaN  NaN  NaN  NaN  NaN  NaN       CYOOm3i   \n",
       "\n",
       "                                           ReactionRule  \n",
       "0     Q8IWW8 or P28332 or Q8N4Q0 or P07327 or P40394...  \n",
       "1                                                P14550  \n",
       "6     P09622 and O00330 and P08559 and P10515 and P2...  \n",
       "7     P07195 or P00338 or Q8IX04 or P07864 or Q6ZMR3...  \n",
       "8     P07195 or P00338 or Q8IX04 or P07864 or Q6ZMR3...  \n",
       "...                                                 ...  \n",
       "7915                                             P53985  \n",
       "7939               P09110 or Q08426 or P51659 or Q15067  \n",
       "7980     P09110 or Q08426 or P51659 or P11712 or Q15067  \n",
       "8008                                             Q00325  \n",
       "8010  P12074 and H0UI06 and P14854 and P15954 and Q9...  \n",
       "\n",
       "[3017 rows x 66 columns]"
      ]
     },
     "execution_count": 334,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "overlap_df_3.dropna(subset = [\"First_column\"], inplace=True)\n",
    "overlap_df_3.to_csv(r'/Users/katemeeson/Desktop/170620212.csv', index = False, header=True)\n",
    "overlap_df_3 #Removed Nans from coverage df. "
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 338,
   "id": "analyzed-cause",
   "metadata": {},
   "outputs": [],
   "source": [
    "#Creating subset of coverage for those reactions with 'and' rules. \n",
    "#These will be filtered manually for those where rules are met with overlapping proteins.\n",
    "and_rules = []\n",
    "or_rules = []\n",
    "\n",
    "for rule in overlap_df_3['ReactionRule']:\n",
    "    if 'and' in rule:\n",
    "        and_rules.append(rule)\n",
    "    if 'and' not in rule:\n",
    "        or_rules.append(rule)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 342,
   "id": "living-stanford",
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "and rules:  599\n",
      "or rules:  2418\n"
     ]
    }
   ],
   "source": [
    "print('and rules: ', len(and_rules)) #599 out of 3017 rules are 'and' rules. These will be filtered manually.\n",
    "print('or rules: ', len(or_rules)) #2418 out of 3017 rules are 'or' rules, and contain those proteins in our overlap so reactions can happen."
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 352,
   "id": "flexible-theater",
   "metadata": {},
   "outputs": [
    {
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       "      <th>1</th>\n",
       "      <td>P14550</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>HMR_3907</td>\n",
       "      <td>P14550</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>7</th>\n",
       "      <td>P07195</td>\n",
       "      <td>Q6ZMR3</td>\n",
       "      <td>P07864</td>\n",
       "      <td>P00338</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>HMR_4281</td>\n",
       "      <td>P07195 or P00338 or Q8IX04 or P07864 or Q6ZMR3...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8</th>\n",
       "      <td>P07195</td>\n",
       "      <td>Q6ZMR3</td>\n",
       "      <td>P07864</td>\n",
       "      <td>P00338</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>HMR_4388</td>\n",
       "      <td>P07195 or P00338 or Q8IX04 or P07864 or Q6ZMR3...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>9</th>\n",
       "      <td>P47895</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>HMR_4283</td>\n",
       "      <td>P43353 or P30838 or P48448 or P47895</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>...</th>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>7859</th>\n",
       "      <td>P51659</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>3HPVSTETCOAhcx</td>\n",
       "      <td>P09110 or Q08426 or P51659 or Q15067</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>7915</th>\n",
       "      <td>P53985</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>ATVACIDMCTtu</td>\n",
       "      <td>P53985</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>7939</th>\n",
       "      <td>P51659</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>DEOXFVShc</td>\n",
       "      <td>P09110 or Q08426 or P51659 or Q15067</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>7980</th>\n",
       "      <td>P51659</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>PROFVSCOAhc</td>\n",
       "      <td>P09110 or Q08426 or P51659 or P11712 or Q15067</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8008</th>\n",
       "      <td>Q00325</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>PIt2mi</td>\n",
       "      <td>Q00325</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>2418 rows × 66 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "     First_column       1       2       3    4    5    6    7    8    9  ...  \\\n",
       "0          P40394  Q8N4Q0  P11766     NaN  NaN  NaN  NaN  NaN  NaN  NaN  ...   \n",
       "1          P14550     NaN     NaN     NaN  NaN  NaN  NaN  NaN  NaN  NaN  ...   \n",
       "7          P07195  Q6ZMR3  P07864  P00338  NaN  NaN  NaN  NaN  NaN  NaN  ...   \n",
       "8          P07195  Q6ZMR3  P07864  P00338  NaN  NaN  NaN  NaN  NaN  NaN  ...   \n",
       "9          P47895     NaN     NaN     NaN  NaN  NaN  NaN  NaN  NaN  NaN  ...   \n",
       "...           ...     ...     ...     ...  ...  ...  ...  ...  ...  ...  ...   \n",
       "7859       P51659     NaN     NaN     NaN  NaN  NaN  NaN  NaN  NaN  NaN  ...   \n",
       "7915       P53985     NaN     NaN     NaN  NaN  NaN  NaN  NaN  NaN  NaN  ...   \n",
       "7939       P51659     NaN     NaN     NaN  NaN  NaN  NaN  NaN  NaN  NaN  ...   \n",
       "7980       P51659     NaN     NaN     NaN  NaN  NaN  NaN  NaN  NaN  NaN  ...   \n",
       "8008       Q00325     NaN     NaN     NaN  NaN  NaN  NaN  NaN  NaN  NaN  ...   \n",
       "\n",
       "       56   57   58   59   60   61   62   63      ReactionID  \\\n",
       "0     NaN  NaN  NaN  NaN  NaN  NaN  NaN  NaN        HMR_3905   \n",
       "1     NaN  NaN  NaN  NaN  NaN  NaN  NaN  NaN        HMR_3907   \n",
       "7     NaN  NaN  NaN  NaN  NaN  NaN  NaN  NaN        HMR_4281   \n",
       "8     NaN  NaN  NaN  NaN  NaN  NaN  NaN  NaN        HMR_4388   \n",
       "9     NaN  NaN  NaN  NaN  NaN  NaN  NaN  NaN        HMR_4283   \n",
       "...   ...  ...  ...  ...  ...  ...  ...  ...             ...   \n",
       "7859  NaN  NaN  NaN  NaN  NaN  NaN  NaN  NaN  3HPVSTETCOAhcx   \n",
       "7915  NaN  NaN  NaN  NaN  NaN  NaN  NaN  NaN    ATVACIDMCTtu   \n",
       "7939  NaN  NaN  NaN  NaN  NaN  NaN  NaN  NaN       DEOXFVShc   \n",
       "7980  NaN  NaN  NaN  NaN  NaN  NaN  NaN  NaN     PROFVSCOAhc   \n",
       "8008  NaN  NaN  NaN  NaN  NaN  NaN  NaN  NaN          PIt2mi   \n",
       "\n",
       "                                           ReactionRule  \n",
       "0     Q8IWW8 or P28332 or Q8N4Q0 or P07327 or P40394...  \n",
       "1                                                P14550  \n",
       "7     P07195 or P00338 or Q8IX04 or P07864 or Q6ZMR3...  \n",
       "8     P07195 or P00338 or Q8IX04 or P07864 or Q6ZMR3...  \n",
       "9                  P43353 or P30838 or P48448 or P47895  \n",
       "...                                                 ...  \n",
       "7859               P09110 or Q08426 or P51659 or Q15067  \n",
       "7915                                             P53985  \n",
       "7939               P09110 or Q08426 or P51659 or Q15067  \n",
       "7980     P09110 or Q08426 or P51659 or P11712 or Q15067  \n",
       "8008                                             Q00325  \n",
       "\n",
       "[2418 rows x 66 columns]"
      ]
     },
     "execution_count": 352,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "or_rules_df = overlap_df_3[~overlap_df_3.ReactionRule.str.contains(\"and\")] \n",
    "or_rules_df #These are the 'or' rules, for which reactions are permitted. Will now filter 'and' rules manually and add this to this df."
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 351,
   "id": "obvious-accreditation",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>First_column</th>\n",
       "      <th>1</th>\n",
       "      <th>2</th>\n",
       "      <th>3</th>\n",
       "      <th>4</th>\n",
       "      <th>5</th>\n",
       "      <th>6</th>\n",
       "      <th>7</th>\n",
       "      <th>8</th>\n",
       "      <th>9</th>\n",
       "      <th>...</th>\n",
       "      <th>56</th>\n",
       "      <th>57</th>\n",
       "      <th>58</th>\n",
       "      <th>59</th>\n",
       "      <th>60</th>\n",
       "      <th>61</th>\n",
       "      <th>62</th>\n",
       "      <th>63</th>\n",
       "      <th>ReactionID</th>\n",
       "      <th>ReactionRule</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>6</th>\n",
       "      <td>P09622</td>\n",
       "      <td>P08559</td>\n",
       "      <td>P11177</td>\n",
       "      <td>P10515</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>HMR_4137</td>\n",
       "      <td>P09622 and O00330 and P08559 and P10515 and P2...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>30</th>\n",
       "      <td>P08559</td>\n",
       "      <td>P11177</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>HMR_6410</td>\n",
       "      <td>( P08559 and P11177 ) or ( P29803 and P11177 )</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>31</th>\n",
       "      <td>P09622</td>\n",
       "      <td>P08559</td>\n",
       "      <td>P11177</td>\n",
       "      <td>P10515</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>HMR_6412</td>\n",
       "      <td>( P09622 and P08559 and P10515 and P11177 ) or...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>159</th>\n",
       "      <td>P09622</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>HMR_3800</td>\n",
       "      <td>P21953 and P09622 and P11182 and P12694</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>205</th>\n",
       "      <td>Q08828</td>\n",
       "      <td>Q8NFM4</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>HMR_4000</td>\n",
       "      <td>( Q02153 and Q02108 ) or P25092 or Q08462 or P...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>...</th>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>7661</th>\n",
       "      <td>P08195</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>PTRCARGte</td>\n",
       "      <td>Q9UM01 and P08195</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>7667</th>\n",
       "      <td>P08195</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>ARGN1ASPMDte</td>\n",
       "      <td>Q92536 and P08195</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>7694</th>\n",
       "      <td>P07602</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>GLA2l</td>\n",
       "      <td>P06280 and P07602</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>7699</th>\n",
       "      <td>P10619</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NEU11l</td>\n",
       "      <td>P10619 and P34059 and P16278 and Q99519</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8010</th>\n",
       "      <td>P00403</td>\n",
       "      <td>P13073</td>\n",
       "      <td>P09669</td>\n",
       "      <td>P14854</td>\n",
       "      <td>P10606</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>CYOOm3i</td>\n",
       "      <td>P12074 and H0UI06 and P14854 and P15954 and Q9...</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>599 rows × 66 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "     First_column       1       2       3       4    5    6    7    8    9  \\\n",
       "6          P09622  P08559  P11177  P10515     NaN  NaN  NaN  NaN  NaN  NaN   \n",
       "30         P08559  P11177     NaN     NaN     NaN  NaN  NaN  NaN  NaN  NaN   \n",
       "31         P09622  P08559  P11177  P10515     NaN  NaN  NaN  NaN  NaN  NaN   \n",
       "159        P09622     NaN     NaN     NaN     NaN  NaN  NaN  NaN  NaN  NaN   \n",
       "205        Q08828  Q8NFM4     NaN     NaN     NaN  NaN  NaN  NaN  NaN  NaN   \n",
       "...           ...     ...     ...     ...     ...  ...  ...  ...  ...  ...   \n",
       "7661       P08195     NaN     NaN     NaN     NaN  NaN  NaN  NaN  NaN  NaN   \n",
       "7667       P08195     NaN     NaN     NaN     NaN  NaN  NaN  NaN  NaN  NaN   \n",
       "7694       P07602     NaN     NaN     NaN     NaN  NaN  NaN  NaN  NaN  NaN   \n",
       "7699       P10619     NaN     NaN     NaN     NaN  NaN  NaN  NaN  NaN  NaN   \n",
       "8010       P00403  P13073  P09669  P14854  P10606  NaN  NaN  NaN  NaN  NaN   \n",
       "\n",
       "      ...   56   57   58   59   60   61   62   63    ReactionID  \\\n",
       "6     ...  NaN  NaN  NaN  NaN  NaN  NaN  NaN  NaN      HMR_4137   \n",
       "30    ...  NaN  NaN  NaN  NaN  NaN  NaN  NaN  NaN      HMR_6410   \n",
       "31    ...  NaN  NaN  NaN  NaN  NaN  NaN  NaN  NaN      HMR_6412   \n",
       "159   ...  NaN  NaN  NaN  NaN  NaN  NaN  NaN  NaN      HMR_3800   \n",
       "205   ...  NaN  NaN  NaN  NaN  NaN  NaN  NaN  NaN      HMR_4000   \n",
       "...   ...  ...  ...  ...  ...  ...  ...  ...  ...           ...   \n",
       "7661  ...  NaN  NaN  NaN  NaN  NaN  NaN  NaN  NaN     PTRCARGte   \n",
       "7667  ...  NaN  NaN  NaN  NaN  NaN  NaN  NaN  NaN  ARGN1ASPMDte   \n",
       "7694  ...  NaN  NaN  NaN  NaN  NaN  NaN  NaN  NaN         GLA2l   \n",
       "7699  ...  NaN  NaN  NaN  NaN  NaN  NaN  NaN  NaN        NEU11l   \n",
       "8010  ...  NaN  NaN  NaN  NaN  NaN  NaN  NaN  NaN       CYOOm3i   \n",
       "\n",
       "                                           ReactionRule  \n",
       "6     P09622 and O00330 and P08559 and P10515 and P2...  \n",
       "30       ( P08559 and P11177 ) or ( P29803 and P11177 )  \n",
       "31    ( P09622 and P08559 and P10515 and P11177 ) or...  \n",
       "159             P21953 and P09622 and P11182 and P12694  \n",
       "205   ( Q02153 and Q02108 ) or P25092 or Q08462 or P...  \n",
       "...                                                 ...  \n",
       "7661                                  Q9UM01 and P08195  \n",
       "7667                                  Q92536 and P08195  \n",
       "7694                                  P06280 and P07602  \n",
       "7699            P10619 and P34059 and P16278 and Q99519  \n",
       "8010  P12074 and H0UI06 and P14854 and P15954 and Q9...  \n",
       "\n",
       "[599 rows x 66 columns]"
      ]
     },
     "execution_count": 351,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "and_rules_df = overlap_df_3[overlap_df_3['ReactionRule'].str.contains(\"and\")]\n",
    "and_rules_df"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 353,
   "id": "christian-furniture",
   "metadata": {},
   "outputs": [],
   "source": [
    "and_rules_df.to_csv(r'/Users/katemeeson/Desktop/18062021andrules.csv', index = False, header=True)\n",
    "or_rules_df.to_csv(r'/Users/katemeeson/Desktop/18062021orrules.csv', index = False, header=True)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "id": "southern-cancer",
   "metadata": {},
   "outputs": [],
   "source": [
    "#Manually filter the 'and' rules and produce final coverage document ready for annotation and FBA. "
   ]
  }
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