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<!DOCTYPE html>
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<html lang="en">
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<title>The Cutting Edge Foundation</title>
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<meta name="author" content="Ellis Sawyer, Ishaan sehgal, Rohan Katakam">
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<div class="header-text"><h1 class="text-center" style="">The Cutting Edge Foundation</h1></div>
<div class="header-text"><p class="lead text-center"><b>Advancing</b> health through surgical innovations</p><br></div>
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<h1 id="about" class="title text-center">Our <span>Mission</span></h1>
<p class="lead text-center">The Cutting Edge Foundation supports innovative surgical procedures that revolutionize the treatment of diseases and change the face of medicine as it exists today.</p>
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<p>The Cutting Edge Foundation funds surgical procedures and surgical research dedicated to advancing the art of surgery for the purpose of finding actual cures for chronic diseases. The focus of our funding efforts is to support the innovations of the Department of Surgery, University of Illinois at Chicago (UIC) in developing minimally invasive, highly precise robotic surgical techniques to treat some of the most challenging and life-threatening diseases, and in finding functional cures of chronic medical conditions. Our goal is to support these efforts and to make these advanced techniques available to those in need of such medical care, including patients with limited financial means.</p>
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<h4 class="media-heading">What is Robotic Surgery?</h4>
<p>Robotic surgery is an innovative and modern technique to perform minimally-invasive surgery using electronic and computerized instruments, as well a superior and magnified 3D vision system.</p>
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<h4 class="media-heading">Is the Robot doing surgery autonomously?</h4>
<p>No it is not! Robot is a misleading word. It is the surgeon who is performing the surgical procedure using the Robot’s electronic tools. The Robot is a kind of master-command system (tele manipulator) that reproduces the movements of the surgeon’s hands.</p>
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<h4 class="media-heading">Is the surgeon far away from the patient?</h4>
<p>The surgeon is in the operative room and very close to the patient, as well as the rest of the surgical team who are located at the patient’s bed side. </p>
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<h4 class="media-heading">Are Da Vinci surgery and Robotic surgery synonymous?</h4>
<p>Yes they are! So far, The Da Vinci robotic system is the only system approved for clinical use.</p>
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<h4 class="media-heading">What does "conversion to open" mean? </h4>
<p>A robotic procedure can be converted to the traditional open surgical approach at any time. Reasons for the conversion can be anatomical complexities, adhesions created from previous surgical procedures and bleeding. The conversion rate is proportional to the difficulty of the procedure, as well as the inexperience of the surgeon. Conversion, by itself, is not a complication, but rather a different approach to successfully complete an operation.</p>
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<h4 class="media-heading">Is the Robot a safe machine?</h4>
<p>Yes it is! It is very rare to encounter any major mechanical or electronic malfunctions of the robotic system. If a system malfunction should occur, there is no risk for the patient. The robotic operation can be finished and converted to the traditional approach (laparoscopic or open).</p>
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<h4 class="media-heading">Are complications more or less frequent in Robotic surgery?</h4>
<p>In more than a million procedures utilizing the Robot it has been widely demonstrated that the robotic approach is not specifically connected to any increased risk of complications when the surgeon is well trained using the robotic system. Lack of experience and improper training are the main reasons for surgical injuries attributed to the Robot. </p>
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<h4 class="media-heading">What are the benefits of minimally-invasive surgery?</h4>
<p>The minimally invasive approach is usually associated with the following benefits: less postoperative pain, less scaring, less blood loss, faster recovery, better convalescence and a faster return to normal life and daily routines.</p>
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<h4 class="media-heading">What are the benefits and advantages of Robotic Surgery?</h4>
<p>With the proper utilization of the robotic technology, more complex procedures can be feasible in a minimally invasive fashion. Examples of these complex procedures include: Resections of the pancreas, liver, lung, esophagus and rectum.</p>
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<h4 class="media-heading">How can an expert robotic surgeon be recognized?</h4>
<p>Many institutions, before granting a surgeon with “robotic privileges”, will verify the competence of the surgeon using this system. There are also Centers of Excellence in Robotic Surgery (accredited by SRS and scientific associations like the Clinical Robotic Surgery Association [CRSA]). Another good way to recognize an expert robotic surgeon is by asking for their personal experience with the Robot (number of cases, conversion rate, outcomes, etc.).</p><br>
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<h1 class="text-center title" id="portfolio">Success Stories</h1>
<div class="separator"></div>
<p class="lead text-center">The following are examples of how this technology is affecting our world today. Stories and biographies are all included in the following blocks of information. In addition, there are pictures to detail different aspects of the da Vinci robot.</p>
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<h3>Joseph's Pancreatic Cancer Story</h3>
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<p>When Joseph told friends he needed a Whipple procedure to treat his pancreatic cancer, some of them became visibly upset. “Anyone who knew anything about the procedure was a little shocked,” recalls Joseph, 62, a retired science teacher from suburban Homewood. “It became clear my condition was more serious than I realized.”</p>
<p>The Whipple, he learned, is among the most complex surgeries performed by general surgeons, calling for creation of a large abdominal opening to remove benign or cancerous tumors in the head of the pancreas, and in adjacent ducts and blood vessels. Patients are left with a long scar, a lengthy hospital stay, significant pain, months of recuperation and risk for infection. But Joseph was lucky. Not only was his cancer detected early, but it also was removed using a noninvasive robotic Whipple, a pioneering technology available at the University of Illinois Medical Center at Chicago.</p>
<p>Another piece of luck: His surgeon was Pier Cristoforo Giulianotti, MD, chief of the center’s division of general, minimally invasive and robotic surgery, who has performed more than 2,000 minimally invasive surgeries, including nearly 1,000 robotic procedures.</p>
<p>Giulianotti says the robotic Whipple requires about the same amount of time as traditional methods, though the result is less blood loss and pain, minimal scarring and shorter recovery time. It’s why Giulianotti, who hails from Pisa, Italy, joined UIC in 2007 as Lloyd M. Nyhus Professor of Surgery. “I felt, here was a place where I could make a contribution,” he recalls.</p>
<p>While robotic surgery is routine for certain conditions, Giulianotti, a general surgeon, has expanded its use to treat life-threatening diseases of the lungs, esophagus, colon, stomach, liver, gall-bladder, kidneys, and pancreas. The center, which performs more than 300 such procedures per year, is a world leader in robotic-assisted surgery.</p>
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<p>Surgery performed by Giulianotti to remove a cancerous lung lobe illustrates why. Before he arrived, Fabio Sbrana, MD, and other team members prepped the patient by making four tiny incisions — three for inserting tiny robotic instruments to excise tissue and tie sutures. The fourth accommodated lighting implements and removal of excised tissue. Giulianotti, meantime, was seated at a console resembling those found in road race video games, his forehead pressed against the instrument so he could access a binocular viewer. Robotic arms translated his gestures via hand and foot controls.</p>
<p>“I can see the patient better than if I were at the operating table,” he says, noting that high-resolution, three-dimensional views are magnified nearly 30-fold. Gripping the hand controls, he explains that the jointed-wrist instruments replicate the surgeon’s motions but allow 360-degree rotation, twice the range of the human hand. To operate the third hand, Giulianotti removed his shoes to increase his sensitivity while pumping pedals.</p>
<p>As surgery proceeded, Giulianotti employed a cauterizing instrument to excise tissue, isolate the cancer and remove it. Once surgery was completed, the day’s schedule called for a robotic Whipple. Giulianotti says it’s not uncommon for UIC to perform one per day, as compared with one per month at other hospitals. Joseph underwent Whipple surgery in January 2009 and left the hospital just 10 days later. “By that point, patients who undergo a traditional Whipple only feel well enough to rise from bed,” he says.</p>
<p>Once home, Joseph resumed normal activity after two months, long before a traditional Whipple would have allowed. “I really feel good,” he says, “and my prognosis is very good.”</p>
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<p>Dr. Pier Giulianotti is Chief of the Division of General, Minimally Invasive and Robotic Surgery at the University of Illinois Chicago Medical Center and known world-wide for his pioneering techniques in treating cancer and other challenging ailments that other surgeons declared untreatable. As a preeminent surgeon in Italy, we are fortunate that Dr. Giulianotti came to Chicago to make it his new home and venue for training the next generation of surgeons; passing along his knowledge in the latest cutting edge techniques.</p>
<p>As both an educator and a highly skilled, world-renowned surgeon, Dr. Giulianotti is contributing to the fabric of Chicago by making these advances accessible to the disadvantaged, the next generation of surgeons and most importantly, patients previously told that their conditions were inoperable.</p>
<p>Prof. Giulianotti received his M.D. degree from La Scuola Normale of Pisa University, Italy. Beside a formal General Surgery Residency at University of Pisa, he has completed two additional Residencies: Digestive and Vascular Surgery. For 10 years he has been Faculty Surgeon at Pisa University. In 1998, he became Director of the General and Minimally Invasive Surgery Division at Misericordia Hospital in Grosseto, Tuscany (Italy) and, after 5 years, Head of the Department of General Surgery at the same Hospital. In 2000, he pioneered the new robotic technology, performing complex procedures such as formal hepatic resection, lung resection and pancreatico-duodenectomy. </p>
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In the last 7 years he has developed one of the largest programs worldwide for Robotic Surgery: the Special School ACOI of Robotic Surgery of which, Prof. Giulianotti is the Director. He is also a faculty member of the Minimally Invasive Training program at the European Surgical Institute, Ethicon Endo-Surgery Norderstedt (Hamburg , Germany) and invited professor at the Institut de Recherché contre les Cancers de l'Appareil Digestif (IRCAD), Strasburg France. Since 1979, he has published over 250 papers in scientific publications on several topics such as pancreatic, vascular, transplant, oncologic, digestive and robotic surgery. Recently, Prof. Giulianotti has been awarded with the prestigious Lloyd M. Nyhus Endowed Chair in Surgery at University of Illinois at Chicago and has been appointed Chief of the Division of General, Minimally Invasive and Robotic Surgery.
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<h3>How a Type 1 Diabetic can Live Without Insulin</h3>
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<q>This is a life-changing experience for those who are eligible, and yes, they say that it’s a ‘functional cure‘ to them.</q><p style="font-style: italic">- Jose Oberholzer, MD, Associate Professor of Surgery</p><br>
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Mr. Bruno Pasquinelli, Jan L. (a recipient of Islet Cell Transplant surgery, Dr. Jose Oberholzer and Dr. Enrico Benedetti
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<h4>Why Type 1 Diabetic Jan L. No Longer Needs Insulin</h4> <p>Jan suffered from Type 1 Diabetes since she was a teenager. But after years of easily managing her diabetes, she realized when she entered medical school that she could no longer feel the symptoms of low blood sugars. "Testing numerous times a day saved me. I would catch myself with a blood sugar of 28 felt almost nothing "Jan suffered from Type 1 Diabetes since she was a teenager. But after years of easily managing her diabetes, she realized when she entered medical school that she could no longer feel the symptoms of low blood sugars. "Testing numerous times a day saved me. I would catch myself with a blood sugar of 28 felt almost nothing"</p>
<h4>A Revolutionary Procedure</h4> <p>While looking for place to volunteer, Jan came across the work being done by Dr. Jose Oberholzer. She first dismissed the possibility of an transplant due to the need for immunosuppression but after meeting with Dr. Oberholzer, Jan volunteered for an islet transplant, a breakthrough procedure designed to prevent many of the know devastating effects of long-term Type 1 diabetes. Mr. Bruno Pasquinelli (pictured above with Jan) sponsored Jan by completely covering the cost of her islet cell transplantation with a generous donation.</p>
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<h4>Her Life Today</h4>
<p>Jan had her transplant in 2011 and continues to be symptom-free of diabetes; she hasn't required an insulin shot since then. The young doctor is now finishing her medical residency. "I cannot imagine how I would have survived the intense schedule and work load had I been having low blood sugars. I am thankful and words are not enough. I can only hope that others, seeing the generosity of Mr. Pasquinelli, realize the magnitude of this procedure and support the efforts to cure diabetes. "I hope to pay it forward one day"</p>
<h4>How it Works</h4>
<p>Dr. Jose Oberholzer has established in record time, a first-class human islet isolation and transplantation program. In his first clinical trial, 10 of 10 brittle diabetic patients who received islet cell transplants achieved insulin-independence.
Islet cell transplantation offers promise of a cell-based, functional cure for diabetes. Transplanted islet cells quickly begin to act as insulin factories, allowing recipients to live insulin-free. By placing the islet cells in protective capsules, there is hope that transplant recipients will not need immunosuppressive drugs to prevent rejection.
Future research to prove these concepts will pave the way for widespread clinical application of a cell-based cure for diabetes. The research is now focused on overcoming the remaining obstacles to islet transplantation.</p>
<h4>Why is this important?</h4>
<p>In the last 20 years, a vast amount of scientific knowledge has been gathered about how insulin-producing cells develop, function and survive in the normal human body and how they become compromised and destroyed in diabetic patients. In recent years, interest in diabetes has intensified because it is nearing epidemic proportions: in 1985 there were 30 million diabetics; today that number has rocketed to more than 194 million. By 2025, diabetes is likely to affect 300 million people worldwide.</p>
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<h3 style="font-style: bold">About Dr. Jose Oberholzer, MD</h3> <hr>
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<p style="font-style: italic">Dr. Jose Oberholzer, MD, is an Associate Professor of Surgery, Endocrinology and Diabetes, and Bioengineering at the University of Illinois at Chicago (UIC)</p>
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<p>Dr. Jose Oberholzer, MD, is an Associate Professor of Surgery, Endocrinology and Diabetes, and Bioengineering at the University of Illinois at Chicago (UIC), the Director of the Islet and Pancreas Transplant Program and the Chief of the Division of Transplantation. He has extensive experience in clinical and experimental islet transplantation, abdominal organ transplantation, as well as advanced hepatobiliary and pancreatic surgery.</p>
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<h3>Living Donor Liver Transplants</h3>
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<q>Thanks to Dr. Jeon, I am a liver cancer survivor. After receiving the devastating news that I had a cancerous tumor in my liver, and learning from four of the leading hospitals that specialize in liver transplants that the large size of the tumor eliminated me as a candidate for a cadaver liver transplant, I thought it would only be a matter of time before I would succumb to this terrible disease. It was then during this stressful and frustrating period that I was miraculously referred to Dr. Jeon at the University of Illinois at Chicago (UIC), and he offered me an opportunity to win the battle over liver cancer—a liver transplant from a living donor. And the living donor would be my daughter, Melinda, who offered to donate her entire right lobe (61% of her liver) to replace my cancerous liver. This option was only possible because of the uniqueness of the liver which is its ability to regenerate itself. Although there are risks to such a surgery to both Melinda and myself, I am forever grateful to Dr. Jeon and his liver transplant team who successfully performed the transplant. The success of this transplant would not have been possible without Dr. Jeon’s exceptional medical skills, commitment, and dedication to his patients. Not only is he a talented surgeon, but his concern for his patients is unmatched. He was always there for us, both day and night, whenever any concerns arose during the recovery period.</q><br><p style="font-style: italic"> --- Carol N</p><br>
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<p>The University of Illinois Medical Center has established a living-donor liver transplant program offering advanced treatment to patients suffering from End-Stage Liver Disease (cirrhosis) or selected cases of liver cancer. Due to a shortage of deceased donor organs which creates significant delay in timely treatment of these patients, University of Illinois surgeons perform living-donor liver transplants between adults. This represents a unique opportunity to provide patients with a timely transplantation while optimizing the patient’s condition. Until recently, very few adults in this country were treated with a partial liver graft from a live donor</p>
<p>The University of Illinois at Chicago Transplant Center liver program was launched in 1985. From their extensive experience in liver transplantation, the institution is able to offer patients with liver diseases opportunities previously not available or even considered possible.</p>
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<li>First adult-to-adult living donor liver transplant in the US (1998)</li>
<li>First coronary artery bypass and liver transplant in the same setting (1998)</li>
<li>First liver and small bowel transplants from same living donor into same recipient worldwide (2004)</li>
<li>First robotic living donor hepatectomy in the US (2005)</li>
<li>One of two programs worldwide offering living donor transplant option for all abdominal organs: kidney liver, pancreas, intestine, combined liver/bowel, combined kidney/pancreas</li>
</ul>
<p>One of the key determinants for the successful improvements for the liver transplant program has been the multi-disciplinary team. Refinement of surgical technique, skillful management of immunosuppressive therapy and prompt diagnosis of rejection are ways University of Illinois surgeons continuously strive to improve post-operative results.</p>
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<h4 class="modal-title" id="project-10-label">Dr. Hoonbae Jeon MD, FACS</h4>
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<h3>About Dr. Hoonbae Jeon MD, FACS </h3><hr>
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<img src="images/drhane.png" alt=""><p style="font-style: italic">Associate Professor of Surgery
Director, Liver Transplantation and Hepatobiliary Surgery
University of Illinois at Chicago</p><br> <p>Dr. Hoonbae Jeon earned his medical degree from Korea University, Seoul, Korea and finished his general surgery residency training at the same institution. Afterward, he joined Asan Medical Center, Ulsan University, Seoul, Korea for his advanced training in hepatobiliary surgery and liver transplantation. This is one of pioneering groups in the world that has performed living-donor liver transplantation and has become the largest liver transplant program in the world for the past decade He came to the US to hone his skills and experience further and continued his training at Mount Sinai School of Medicine, New York, which was the leading institution in living-donor liver transplantation in early 2000’s.</p>
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<p>He joined the University of Illinois as the surgical director of liver transplantation and primary living-donor liver transplant surgeon. He has been devoting himself for not only maintaining prestigious tradition of the liver transplant program, but also accomplishing multiple innovations in living donor liver transplantation, such as multidisciplinary approach for cholangiocarcinoma (which took Walter Payton’s life away), minimally invasive approach to donor liver resection, and aggressive weight loss program for possible donor candidate to expand the organ pool.</p><br>
<h4>Licensure and Board Certifications</h4>
<ul>
<li>National Medial Licensure of Korea (No. 40402)</li>
<li>Board Certified in General Surgery (Republic of Korea)</li>
<li>ASTS Certification of Transplant Fellowship</li>
<li>Kentucky, Illinois Medical License</li>
<li>Fellow, American College of Surgeons</li>
<li>UNOS certified primary living donor liver transplant surgeon at the University of Illinois</li>
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<h4>Research Interest</h4>
<ul>
<li>Partial liver transplantation (live donor and split)</li>
<li>Expansion of donor pool in transplantation</li></ul>
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<h2>Patient Testimonial for Dr. Pier Giulianotti,
Anna C., Evanston, IL</h2> <br>
I found myself under the surgical care of Dr. Giulianotti for very unique circumstances. Unlike many of his patients, my case was due to an accidental emergency. I was at work when, thinking it was my water, I unintentionally drank concentrated industrial dishwashing detergent which had been left unattended. The liquid burned my mouth and entire esophagus immediately upon contact and then again when I vomited the liquid. I was in serious pain and was taken to a small hospital in Wisconsin right away. After intubating me and giving me a series of tests, they determined they were not equipped to handle my injury. It was clear that I was in very serious condition and that if my injuries were not attended to properly, I would face death.
My distraught husband and parents spent many hours determining which hospital to transfer me to in Chicago. A friend of my mother’s who is a doctor at the University of Illinois at Chicago Hospital (UIC) insisted that I would be in the best surgical hands if they transferred me there. Not long after their conversation, Dr. Benedetti, the chief of surgery, called my mom personally and assured her that I would be put in world-class hands; namely, Dr. Giulianotti. Dr. Benedetti also promised my family that he would take personal charge of my case. During this scary time, my husband and parents felt secure in the confidence of this UIC surgical team and had me transferred.
The surgical team offered clear guidance to my husband and family during this extremely scary and uncertain time. They came up with a plan and back up plans in order to provide me with the best possible outcome. They hoped to wait to do the surgery in order to give my esophagus an opportunity to heal but they were prepared to go into surgery should my esophagus perforate. My esophagus did end up perforating and they had to take me into emergency surgery. Dr. Giulianotti performed an impeccable robotic surgery under this unique acute circumstance. He removed my esophagus and pulled my stomach up and attached it to the small remaining portion of my esophagus, which now serves as the tube for food to pass through.
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Unbelievably, this major surgery was done solely through two small incisions.While I imagine there is uncertainty in every surgery, the severe and emergent circumstances of my case demanded sound navigation and extreme precision from Dr. Giulianotti.
I came out of surgery without undergoing any of the many possible complications. The intubation was able to come out of my throat only a few days later. As soon as they took the tube out I could talk, I passed my swallow test and began drinking clear liquids only a day after the tube came out, and then I was able to quickly progress to solids. I was out of the hospital not even two weeks after being admitted and undergoing this huge surgery. It became clear to me that this was an unbelievable timeline and it was due to the robotic surgical techniques of Dr. Giulianotti.
I am now essentially back to my daily routine. It blows my mind that my stomach has seamlessly taken the place of my esophagus, that I can eat and function as a normal human, that my recovery process was so relatively smooth, and that I escaped every complication.
I can’t say enough about the personal care and attention I received form Dr. Giulianotti and Dr. Benedetti. It was clear from the moment I met these surgeons that they not only offered me their world-class medical attention but that they put their whole hearts into this work. I felt cared for as a whole person, not just as a surgical case. I experienced not only their remarkable medical expertise but also their empathy and compassion. And when your life is on the line - you want doctors who have put their entire hearts and souls into the work they are doing.
Dr. Giulianotti is unbelievably passionate about this work, and as a result, I get to wake up every morning breathing, swallowing, eating, and conducting essentially the same quality of life I had before my terrible accident. I am eternally grateful for this man’s surgical genius and for all of the time and energy he has dedicated specifically to minimally invasive and robotic surgery. I honestly cannot say I would be living to write this testimonial if it were not for his hard work and dedication. My beating heart is full of gratitude for Dr. Giulianotti and for all those who support his work.
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<br><p style="font-style: italic"> --- Anna C., Evanston, IL</p>
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<h3>Dave D., Palos Park, IL</h3>
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In 2012, I was diagnosed with a huge paraesophageal hernia. I was unable to eat a normal dinner. If I did, I would suffer SEVERE abdominal pain and would actually have to lie down for hours until the food digested from my stomach. Part of this was that my hernia would actually close off my esophagus and I wasn’t able to expel gaseous products of digestion. Also, when lying down, my full stomach would actually end up lying against my heart and I would feel chest pains.
The surgeon in my medical group did not want to attempt the surgery. I asked him if he had to do it, how would he proceed.
He said he would end up making a very large incision and then try to figure out how to make the needed repair. He told me I would be off of work for a very long time.
I ended up making an appointment with Dr. Guilianotti, a very experienced and confident surgeon. Within 15 minutes of my first visit with him, he had an immediate plan of action on how to repair my hernia.
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The surgery consisted of meshing my diaphragm and esophagus, robotically. I had small incisions (1/2-3/4”), a minimal hospital stay, and was up and walking the very next morning.
In my mind, the robotically performed surgery gave me small incisions, less chance of infection, and minimal recovery time. I was back to my normal life shortly after surgery. I did not even contemplate traditional surgery based on having a large incision, greater chance of infection, and a long recovery time, not to mention my medical group surgeon’s lack of confidence with this type of surgery.
Since this surgery, Dr. Guilianotti has performed left and right side inguinal hernia repair on me. Both surgeries were performed robotically and with the same results as my paraesophageal hernia repair!
I would recommend both robotic surgery and Dr. Guillanotti enthusiastically and without hesitation.
<br><p style="font-style: italic"> --- Dave D., Palos Park, IL</p>
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