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<!DOCTYPE html>
<html>
<head>
<meta charset="utf-8">
<title>Graham Holt</title>
<meta name="viewport" content="width=device-width, initial-scale=1.0">
<link href="https://fonts.googleapis.com/css?family=Catamaran:100,200,300,400,500,600,700,800,900|Cormorant+Garamond:300,300i,400,400i,500,500i,600,600i,700,700i", rel="stylesheet">
<link rel="stylesheet" href="style.css">
</head>
<body>
<header>
<a href="index.html" class="header-brand">GTH</a>
<nav>
<ul>
<li><a href="research.html">Research</a></li>
<li><a href="about.html">About Me</a></li>
<li><a href="contact.html">Contact</a></li>
</ul>
<a href="resources/resume.pdf" class="header-link-special">Resume</a>
</nav>
</header>
<main>
<div class="wrapper">
<section class="publications-links">
<h1>Talks & Teaching</h1>
<div class="publications-year">
<h2>2022</h2>
<div class="citation-link">
<cite><b>Ensemble-based computational protein design: Algorithms and applications</b>. Dissertation defense seminar, <i>Duke University Program in Computational Biology & Bioinformatics</i>. April 20, 2022.</cite>
</div>
<div class="citation-link">
<cite><b><i>In silico</i> design of V2-apex antibodies yields improved HIV-1 breadth and potency by improving non-conserved side chain interactions</b>. Oral presentation, <i>Joint HIV-1 Meeting (Passive), Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), NIH</i>. March 2022.</cite>
</div>
</div>
<div class="publications-year">
<h2>2021</h2>
<div class="citation-link">
<cite><b>Ensemble-based computational protein design: Algorithms and applications</b>. Oral presentation, <i>Departmental seminar for the Duke University Program in Computational Biology & Bioinformatics</i>. October 2021.</cite>
</div>
</div>
<div class="publications-year">
<h2>2019</h2>
<div class="citation-link">
<cite><b>Using Ensemble-Based Computational Protein Design to Propose Mechanisms of Binding and Resistance</b>. Contributed talk at <i>Duke Biochemistry Department Retreat</i>. October 26, 2019.</cite>
</div>
<div class="citation-link">
<cite>Head TA for <b>Discrete Mathematics for Computer Science (COSC230)</b>. <i>Duke University Department of Computer Science</i>. Fall 2019.</cite>
</div>
<div class="citation-link">
<cite><b>Minimization-Aware Recursive K*: A novel, provable algorithm that accelerates ensemble-based protein design and provably approximates the energy landscape</b>. Contributed talk at <i>Research in Computational Molecular Biology (RECOMB)</i>. May 6, 2019.</cite>
</div>
</div>
<div class="publications-year">
<h2>2018</h2>
<div class="citation-link">
<cite><b>Minimization-Aware Recursive K* (MARK*) enables approximation and visualization of energy landscapes</b>. Poster presentation at the <i>Duke Computational Biology & Informatics Program Retreat</i>. October 2018.</cite>
</div>
<div class="citation-link">
<cite>TA for <b>Discrete Mathematics for Computer Science (COSC230)</b>. <i>Duke University Department of Computer Science</i>. Fall 2018.</cite>
</div>
</div>
<div class="publications-year">
<h2>2012</h2>
<div class="citation-link">
<cite><b>Transcriptional Regulation of XPG in the DNA Damage Response</b>. Poster presentation at the <i>Lawrence Berkeley National Laboratory Science Undergraduate Laboratory Intern Program</i>. 2012.</cite>
</div>
</div>
</section>
<a href="contact.html">
<div class="projects-contact-link">
<h2>Contact me</h2>
<img src="img/email.png" alt="get away nasty bots">
</div>
</a>
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<footer>
<ul class="footer-links-main">
<li><a href="index.html">Home</a></li>
<li><a href="research.html">Research</a></li>
<li><a href="publications.html">Publications</a></li>
<li><a href="talks.html">Talks & Teaching</a></li>
<li><a href="about.html">About me</a></li>
<li><a href="contact.html">Contact</a></li>
</ul>
<ul class="footer-links-papers">
<li><p>Latest Papers</p></li>
<li><a href="https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1009855">Mechanisms of antifolate resistance in S. aureus</a></li>
<li><a href="https://doi.org/10.1371/journal.pcbi.1007447">Redesign of the c-Raf-RBD:KRas protein-protein interface</a></li>
<li><a href="https://doi.org/10.1089/cmb.2019.0315">Minimization-Aware Recursive K* (MARK*)</a></li>
<li><a href="https://doi.org/10.1021/acs.jpcb.9b07278">Energy landscapes of CFTR-associated ligand inhibitors</a></li>
<li><a href="https://doi.org/10.1021/acsinfecdis.9b00222">Toward broad spectrum dihydrofolate reductase inhibitors</a></li>
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<a href="https://github.com/grahamtholt">
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