diff --git a/pkg/querier/queryrange/queryrangebase/retry.go b/pkg/querier/queryrange/queryrangebase/retry.go
index f02b5d73cd6c4..a3f2693b1ba75 100644
--- a/pkg/querier/queryrange/queryrangebase/retry.go
+++ b/pkg/querier/queryrange/queryrangebase/retry.go
@@ -7,9 +7,10 @@ import (
 	"github.com/go-kit/log"
 	"github.com/go-kit/log/level"
 	"github.com/grafana/dskit/backoff"
-	"github.com/grafana/dskit/httpgrpc"
+	"github.com/grafana/dskit/grpcutil"
 	"github.com/prometheus/client_golang/prometheus"
 	"github.com/prometheus/client_golang/prometheus/promauto"
+	"google.golang.org/grpc/codes"
 
 	"github.com/grafana/loki/v3/pkg/util"
 	util_log "github.com/grafana/loki/v3/pkg/util/log"
@@ -88,9 +89,8 @@ func (r retry) Do(ctx context.Context, req Request) (Response, error) {
 			return resp, nil
 		}
 
-		// Retry if we get a HTTP 500 or a non-HTTP error.
-		httpResp, ok := httpgrpc.HTTPResponseFromError(err)
-		if !ok || httpResp.Code/100 == 5 {
+		// Retry if we get a HTTP 500 or an unknown error.
+		if code := grpcutil.ErrorToStatusCode(err); code == codes.Unknown || code/100 == 5 {
 			lastErr = err
 			level.Error(util_log.WithContext(ctx, r.log)).Log(
 				"msg", "error processing request",
diff --git a/pkg/querier/queryrange/queryrangebase/retry_test.go b/pkg/querier/queryrange/queryrangebase/retry_test.go
index 7476fa21a06b2..f3a33b45c9d1e 100644
--- a/pkg/querier/queryrange/queryrangebase/retry_test.go
+++ b/pkg/querier/queryrange/queryrangebase/retry_test.go
@@ -8,9 +8,11 @@ import (
 	"testing"
 
 	"github.com/go-kit/log"
+	"github.com/gogo/status"
 	"github.com/grafana/dskit/httpgrpc"
 	"github.com/stretchr/testify/require"
 	"go.uber.org/atomic"
+	"google.golang.org/grpc/codes"
 
 	"github.com/grafana/loki/v3/pkg/util/constants"
 )
@@ -19,10 +21,11 @@ func TestRetry(t *testing.T) {
 	var try atomic.Int32
 
 	for _, tc := range []struct {
-		name    string
-		handler Handler
-		resp    Response
-		err     error
+		name          string
+		handler       Handler
+		resp          Response
+		err           error
+		expectedCalls int
 	}{
 		{
 			name: "retry failures",
@@ -32,21 +35,26 @@ func TestRetry(t *testing.T) {
 				}
 				return nil, fmt.Errorf("fail")
 			}),
-			resp: &PrometheusResponse{Status: "Hello World"},
+			resp:          &PrometheusResponse{Status: "Hello World"},
+			expectedCalls: 5,
 		},
 		{
 			name: "don't retry 400s",
 			handler: HandlerFunc(func(_ context.Context, req Request) (Response, error) {
+				try.Inc()
 				return nil, httpgrpc.Errorf(http.StatusBadRequest, "Bad Request")
 			}),
-			err: httpgrpc.Errorf(http.StatusBadRequest, "Bad Request"),
+			err:           httpgrpc.Errorf(http.StatusBadRequest, "Bad Request"),
+			expectedCalls: 1,
 		},
 		{
 			name: "retry 500s",
 			handler: HandlerFunc(func(_ context.Context, req Request) (Response, error) {
+				try.Inc()
 				return nil, httpgrpc.Errorf(http.StatusInternalServerError, "Internal Server Error")
 			}),
-			err: httpgrpc.Errorf(http.StatusInternalServerError, "Internal Server Error"),
+			err:           httpgrpc.Errorf(http.StatusInternalServerError, "Internal Server Error"),
+			expectedCalls: 5,
 		},
 		{
 			name: "last error",
@@ -56,7 +64,28 @@ func TestRetry(t *testing.T) {
 				}
 				return nil, httpgrpc.Errorf(http.StatusInternalServerError, "Internal Server Error")
 			}),
-			err: httpgrpc.Errorf(http.StatusBadRequest, "Bad Request"),
+			err:           httpgrpc.Errorf(http.StatusBadRequest, "Bad Request"),
+			expectedCalls: 5,
+		},
+		// previous entires in this table use httpgrpc.Errorf for generating the error which also populates the Details field with the marshalled http response.
+		// Next set of tests validate the retry behavior when using protobuf encoding where the status does not include the details.
+		{
+			name: "protobuf enc don't retry 400s",
+			handler: HandlerFunc(func(_ context.Context, req Request) (Response, error) {
+				try.Inc()
+				return nil, status.New(codes.Code(http.StatusBadRequest), "Bad Request").Err()
+			}),
+			err:           status.New(codes.Code(http.StatusBadRequest), "Bad Request").Err(),
+			expectedCalls: 1,
+		},
+		{
+			name: "protobuf enc retry 500s",
+			handler: HandlerFunc(func(_ context.Context, req Request) (Response, error) {
+				try.Inc()
+				return nil, status.New(codes.Code(http.StatusInternalServerError), "Internal Server Error").Err()
+			}),
+			err:           status.New(codes.Code(http.StatusInternalServerError), "Internal Server Error").Err(),
+			expectedCalls: 5,
 		},
 	} {
 		t.Run(tc.name, func(t *testing.T) {
@@ -68,6 +97,7 @@ func TestRetry(t *testing.T) {
 			resp, err := h.Do(context.Background(), req)
 			require.Equal(t, tc.err, err)
 			require.Equal(t, tc.resp, resp)
+			require.EqualValues(t, tc.expectedCalls, try.Load())
 		})
 	}
 }