diff --git a/centipede/BUILD b/centipede/BUILD
index 7aa5030a..1b58e1e7 100644
--- a/centipede/BUILD
+++ b/centipede/BUILD
@@ -1022,13 +1022,18 @@ RUNNER_SOURCES_NO_MAIN = [
 
 RUNNER_SOURCES_WITH_MAIN = RUNNER_SOURCES_NO_MAIN + ["runner_main.cc"]
 
+RUNNER_FUZZTEST_COPTS = select({
+    "@com_google_fuzztest//fuzztest:use_centipede": ["-DCENTIPEDE_RUNNER_NO_MUTATE_LIB"],
+    "//conditions:default": [],
+})
+
 # Disable sancov and sanitizer instrumentation
-RUNNER_COPTS = [
+RUNNER_COPTS = RUNNER_FUZZTEST_COPTS + [
     "-fsanitize-coverage=0",
     "-fno-sanitize=address,hwaddress,memory,thread,undefined",
 ]
 
-RUNNER_SANITIZED_COPTS = [
+RUNNER_SANITIZED_COPTS = RUNNER_FUZZTEST_COPTS + [
     "-fsanitize-coverage=0",
 ]
 
diff --git a/centipede/runner.cc b/centipede/runner.cc
index 78c00983..8ea58835 100644
--- a/centipede/runner.cc
+++ b/centipede/runner.cc
@@ -328,6 +328,7 @@ void GlobalRunnerState::ResetTimers() {
   }
 }
 
+#ifndef CENTIPEDE_RUNNER_NO_MUTATE_LIB
 // Byte array mutation fallback for a custom mutator, as defined here:
 // https://github.com/google/fuzzing/blob/master/docs/structure-aware-fuzzing.md
 extern "C" size_t LLVMFuzzerMutate(uint8_t *data, size_t size,
@@ -352,6 +353,7 @@ extern "C" size_t LLVMFuzzerMutate(uint8_t *data, size_t size,
   memcpy(data, array.data(), array.size());
   return array.size();
 }
+#endif  // CENTIPEDE_RUNNER_NO_MUTATE_LIB
 
 // An arbitrary large size for input data.
 static const size_t kMaxDataSize = 1 << 20;
diff --git a/fuzztest/llvm_fuzzer_wrapper.cc b/fuzztest/llvm_fuzzer_wrapper.cc
index bbdd7f3a..28048741 100644
--- a/fuzztest/llvm_fuzzer_wrapper.cc
+++ b/fuzztest/llvm_fuzzer_wrapper.cc
@@ -16,9 +16,7 @@
 #include "./fuzztest/internal/domains/container_of_impl.h"
 #include "./fuzztest/internal/domains/domain_base.h"
 #include "./fuzztest/internal/io.h"
-#ifndef FUZZTEST_USE_CENTIPEDE
 #include "./fuzztest/internal/coverage.h"
-#endif
 
 ABSL_DECLARE_FLAG(std::string, llvm_fuzzer_wrapper_dict_file);
 ABSL_DECLARE_FLAG(std::string, llvm_fuzzer_wrapper_corpus_dir);
@@ -127,9 +125,6 @@ class InplaceVector {
   std::size_t size_;
 };
 
-// Centipede runner also provides LLVMFuzzerMutate to support libFuzzer targets
-// on its own. So we do not define it when integrating with Centipede.
-#ifndef FUZZTEST_USE_CENTIPEDE
 
 extern "C" size_t LLVMFuzzerMutate(uint8_t* data, size_t size,
                                    size_t max_size) {
@@ -147,8 +142,6 @@ extern "C" size_t LLVMFuzzerMutate(uint8_t* data, size_t size,
   return val.size();
 }
 
-#endif
-
 class ArbitraryByteVector
     : public fuzztest::internal::SequenceContainerOfImpl<
           std::vector<uint8_t>, fuzztest::internal::ArbitraryImpl<uint8_t>> {