diff --git a/CMakeLists.txt b/CMakeLists.txt
index 1b41797771..34fe0c9c51 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -137,15 +137,17 @@ if(VITA)
 	set(USE_GLES2 ON)
 	enable_language(ASM)
 
-	add_executable(${PROJECT_NAME} core/emulator.cpp)
-	target_compile_definitions(${PROJECT_NAME} PRIVATE EGL_NO_PLATFORM_SPECIFIC_TYPES)
-	# target_compile_definitions(${PROJECT_NAME} PRIVATE TARGET_NO_EXCEPTIONS)
-	target_compile_definitions(${PROJECT_NAME} PRIVATE VITA _GNU_SOURCE)
-	target_compile_definitions(${PROJECT_NAME} PRIVATE GLES)
-
-	# For proper fseek/ftell definition in external dependency "libchdr", doesn't impact anything else:
-	target_compile_definitions(${PROJECT_NAME} PRIVATE __PS3__)
+	if(LIBRETRO)
+		add_library(${PROJECT_NAME} STATIC core/emulator.cpp)
+		target_compile_definitions(${PROJECT_NAME} PRIVATE LIBRETRO VITA)
+		set_target_properties(${PROJECT_NAME} PROPERTIES OUTPUT_NAME "flycast_libretro_vita")
+	else()
+		add_executable(${PROJECT_NAME} core/emulator.cpp)
+		target_compile_definitions(${PROJECT_NAME} PRIVATE EGL_NO_PLATFORM_SPECIFIC_TYPES)
+	endif()
 
+	target_compile_definitions(${PROJECT_NAME} PRIVATE _GNU_SOURCE)
+	target_compile_definitions(${PROJECT_NAME} PRIVATE GLES)
 elseif(NINTENDO_SWITCH)
 	set(USE_VULKAN OFF)
 	enable_language(ASM)
@@ -638,7 +640,7 @@ target_sources(${PROJECT_NAME} PRIVATE
 		core/deps/chdpsr/cdipsr.h)
 
 add_subdirectory(core/deps/nowide EXCLUDE_FROM_ALL)
-target_compile_definitions(nowide PRIVATE $<$<BOOL:${NINTENDO_SWITCH}>:_DEFAULT_SOURCE>)
+target_compile_definitions(nowide PRIVATE $<$<BOOL:${NINTENDO_SWITCH}>:_DEFAULT_SOURCE> $<$<BOOL:${VITA}>:_GNU_SOURCE>)
 target_link_libraries(${PROJECT_NAME} PRIVATE nowide::nowide)
 
 if(NOT MINIUPNP_FOUND)
@@ -659,7 +661,7 @@ if(NOT MINIUPNP_FOUND)
 	endif()
 endif()
 
-if(NOT LIBZIP_FOUND OR NINTENDO_SWITCH OR VITA)
+if(NOT LIBZIP_FOUND OR NINTENDO_SWITCH)
 	option(ENABLE_COMMONCRYPTO "Enable use of CommonCrypto" OFF)
 	option(ENABLE_GNUTLS "Enable use of GnuTLS" OFF)
 	option(ENABLE_MBEDTLS "Enable use of mbed TLS" OFF)
@@ -1867,16 +1869,20 @@ if(NINTENDO_SWITCH)
 endif()
 
 if(VITA)
-	vita_create_self(eboot.bin ${PROJECT_NAME} UNSAFE STRIPPED NOASLR)
-	vita_create_vpk(${VITA_VPKNAME}.vpk ${VITA_TITLEID} eboot.bin
-		VERSION ${VITA_VERSION}
-		NAME ${VITA_APP_NAME}
-		FILE ${CMAKE_SOURCE_DIR}/shell/vita/icon0.png sce_sys/icon0.png
-		${CMAKE_SOURCE_DIR}/shell/vita/startup.png sce_sys/livearea/contents/startup.png
-		${CMAKE_SOURCE_DIR}/shell/vita/bg.png sce_sys/livearea/contents/bg.png
-		${CMAKE_SOURCE_DIR}/shell/vita/template.xml sce_sys/livearea/contents/template.xml
-		${VPK_INCLUDES}
-	)
+	if(LIBRETRO)
+		# TODO?
+	else()
+		vita_create_self(eboot.bin ${PROJECT_NAME} UNSAFE STRIPPED NOASLR)
+		vita_create_vpk(${VITA_VPKNAME}.vpk ${VITA_TITLEID} eboot.bin
+			VERSION ${VITA_VERSION}
+			NAME ${VITA_APP_NAME}
+			FILE ${CMAKE_SOURCE_DIR}/shell/vita/icon0.png sce_sys/icon0.png
+			${CMAKE_SOURCE_DIR}/shell/vita/startup.png sce_sys/livearea/contents/startup.png
+			${CMAKE_SOURCE_DIR}/shell/vita/bg.png sce_sys/livearea/contents/bg.png
+			${CMAKE_SOURCE_DIR}/shell/vita/template.xml sce_sys/livearea/contents/template.xml
+			${VPK_INCLUDES}
+		)
+	endif()
 endif()
 
 if(IOS)
diff --git a/core/deps/imgui/backends/imgui_impl_opengl3.cpp b/core/deps/imgui/backends/imgui_impl_opengl3.cpp
index c0d2a17069..d2653f76ab 100644
--- a/core/deps/imgui/backends/imgui_impl_opengl3.cpp
+++ b/core/deps/imgui/backends/imgui_impl_opengl3.cpp
@@ -502,8 +502,10 @@ static bool ImGui_ImplOpenGL3_CreateDeviceObjects()
     glLinkProgram(g_ShaderHandle);
     CheckProgram(g_ShaderHandle, "shader program");
 
+#ifndef __vita__
     glDetachShader(g_ShaderHandle, vert_handle);
     glDetachShader(g_ShaderHandle, frag_handle);
+#endif
     glDeleteShader(vert_handle);
     glDeleteShader(frag_handle);
 
diff --git a/core/deps/vixl/code-buffer-vixl.cc b/core/deps/vixl/code-buffer-vixl.cc
index b22ba3320d..2cfe8b71d3 100644
--- a/core/deps/vixl/code-buffer-vixl.cc
+++ b/core/deps/vixl/code-buffer-vixl.cc
@@ -25,12 +25,10 @@
 // OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE.
 
 #ifdef VIXL_CODE_BUFFER_MMAP
-#ifndef __vita__
 extern "C" {
 #include <sys/mman.h>
 }
 #endif
-#endif
 
 #include "code-buffer-vixl.h"
 #include "utils-vixl.h"
diff --git a/core/linux-dist/main.cpp b/core/linux-dist/main.cpp
index 1940efdb10..8a87e8699a 100644
--- a/core/linux-dist/main.cpp
+++ b/core/linux-dist/main.cpp
@@ -220,7 +220,7 @@ std::string find_user_data_dir()
 #endif
 }
 
-#ifndef __SWITCH__
+#if !defined(__SWITCH__) && !defined(__vita__)
 static void addDirectoriesFromPath(std::vector<std::string>& dirs, const std::string& path, const std::string& suffix)
 {
 	std::string::size_type pos = 0;
diff --git a/core/rend/gles/gles.cpp b/core/rend/gles/gles.cpp
index 5668b4619c..1ee717ce43 100644
--- a/core/rend/gles/gles.cpp
+++ b/core/rend/gles/gles.cpp
@@ -973,8 +973,10 @@ GLuint gl_CompileAndLink(const char *vertexShader, const char *fragmentShader)
 		INFO_LOG(RENDERER, "// FRAGMENT SHADER\n%s\n// END", fragmentShader);
 		die("shader compile fail\n");
 	}
+#ifndef __vita__
 	glDetachShader(program, vs);
 	glDetachShader(program, ps);
+#endif
 	glDeleteShader(vs);
 	glDeleteShader(ps);
 
diff --git a/shell/libretro/libretro.cpp b/shell/libretro/libretro.cpp
index 963b6343e5..4756715898 100644
--- a/shell/libretro/libretro.cpp
+++ b/shell/libretro/libretro.cpp
@@ -29,6 +29,10 @@
 #include "nswitch.h"
 #endif
 
+#ifdef __vita__
+#include <sys/syslimits.h> // for PATH_MAX
+#endif
+
 #include <sys/stat.h>
 #include <file/file_path.h>
 
diff --git a/shell/libretro/oslib.cpp b/shell/libretro/oslib.cpp
index 4f7bfa8729..e52158ad20 100644
--- a/shell/libretro/oslib.cpp
+++ b/shell/libretro/oslib.cpp
@@ -20,6 +20,10 @@
 #include "stdclass.h"
 #include "file/file_path.h"
 
+#ifdef __vita__
+#include <sys/syslimits.h> // for PATH_MAX
+#endif
+
 const char *retro_get_system_directory();
 
 extern char game_dir_no_slash[1024];