diff --git a/Lib/test/test_uuid.py b/Lib/test/test_uuid.py
index e177464c00f7a6..291efa031986d8 100755
--- a/Lib/test/test_uuid.py
+++ b/Lib/test/test_uuid.py
@@ -781,29 +781,14 @@ class TestUUIDWithExtModule(BaseTestUUID, unittest.TestCase):
 class BaseTestInternals:
     _uuid = py_uuid
 
-    def check_parse_mac(self, aix):
-        if not aix:
-            patch = mock.patch.multiple(self.uuid,
-                                        _MAC_DELIM=b':',
-                                        _MAC_OMITS_LEADING_ZEROES=False)
-        else:
-            patch = mock.patch.multiple(self.uuid,
-                                        _MAC_DELIM=b'.',
-                                        _MAC_OMITS_LEADING_ZEROES=True)
+    def check_parse_mac(self, valid_macs, delim=b':', omits_leading_zeros=False):
+        patch = mock.patch.multiple(self.uuid,
+                                    _MAC_DELIM=delim,
+                                    _MAC_OMITS_LEADING_ZEROES=omits_leading_zeros)
 
         with patch:
             # Valid MAC addresses
-            if not aix:
-                tests = (
-                    (b'52:54:00:9d:0e:67', 0x5254009d0e67),
-                    (b'12:34:56:78:90:ab', 0x1234567890ab),
-                )
-            else:
-                # AIX format
-                tests = (
-                    (b'fe.ad.c.1.23.4', 0xfead0c012304),
-                )
-            for mac, expected in tests:
+            for mac, expected in valid_macs:
                 self.assertEqual(self.uuid._parse_mac(mac), expected)
 
             # Invalid MAC addresses
@@ -822,16 +807,38 @@ def check_parse_mac(self, aix):
                 # dash separator
                 b'52-54-00-9d-0e-67',
             ):
-                if aix:
-                    mac = mac.replace(b':', b'.')
+                if delim != b':':
+                    mac = mac.replace(b':', delim)
                 with self.subTest(mac=mac):
                     self.assertIsNone(self.uuid._parse_mac(mac))
 
     def test_parse_mac(self):
-        self.check_parse_mac(False)
+        self.check_parse_mac(
+            valid_macs=(
+                (b'52:54:00:9d:0e:67', 0x5254009d0e67),
+                (b'12:34:56:78:90:ab', 0x1234567890ab),
+            ),
+            delim=b':',
+            omits_leading_zeros=False,
+        )
 
     def test_parse_mac_aix(self):
-        self.check_parse_mac(True)
+        self.check_parse_mac(
+            valid_macs=(
+                (b'fe.ad.c.1.23.4', 0xfead0c012304),
+            ),
+            delim=b'.',
+            omits_leading_zeros=True,
+        )
+
+    def test_parse_mac_macos(self):
+        self.check_parse_mac(
+            valid_macs=(
+                (b'1:0:5e:0:c:fb', 0x01005e000cfb),
+            ),
+            delim=b':',
+            omits_leading_zeros=True,
+        )
 
     def test_find_under_heading(self):
         data = '''\
@@ -917,6 +924,25 @@ def test_find_mac_near_keyword(self):
 
         self.assertEqual(mac, 0x1234567890ab)
 
+    def test_find_mac_near_keyword_macos(self):
+        data = '''
+? (224.0.0.251) at 1:0:5e:0:0:fb on en0 ifscope permanent [ethernet]
+'''
+
+        with mock.patch.multiple(self.uuid,
+                                 _MAC_DELIM=b':',
+                                 _MAC_OMITS_LEADING_ZEROES=True,
+                                 _get_command_stdout=mock_get_command_stdout(data)):
+
+            mac = self.uuid._find_mac_near_keyword(
+                command='arp',
+                args='-an',
+                keywords=[os.fsencode('(%s)' % '224.0.0.251')],
+                get_word_index=lambda x: x + 2,
+            )
+
+        self.assertEqual(mac, 0x01005e0000fb)
+
     def check_node(self, node, requires=None):
         if requires and node is None:
             self.skipTest('requires ' + requires)
diff --git a/Lib/uuid.py b/Lib/uuid.py
index c286eac38e1ef4..1dd7b7998be13c 100644
--- a/Lib/uuid.py
+++ b/Lib/uuid.py
@@ -69,6 +69,8 @@
 if _AIX:
     _MAC_DELIM = b'.'
     _MAC_OMITS_LEADING_ZEROES = True
+if sys.platform == 'darwin':
+    _MAC_OMITS_LEADING_ZEROES = True
 
 RESERVED_NCS, RFC_4122, RESERVED_MICROSOFT, RESERVED_FUTURE = [
     'reserved for NCS compatibility', 'specified in RFC 4122',
@@ -430,8 +432,8 @@ def _find_mac_near_keyword(command, args, keywords, get_word_index):
             if words[i] in keywords:
                 try:
                     word = words[get_word_index(i)]
-                    mac = int(word.replace(_MAC_DELIM, b''), 16)
-                except (ValueError, IndexError):
+                    mac = _parse_mac(word)
+                except IndexError:
                     # Virtual interfaces, such as those provided by
                     # VPNs, do not have a colon-delimited MAC address
                     # as expected, but a 16-byte HWAddr separated by
@@ -439,7 +441,7 @@ def _find_mac_near_keyword(command, args, keywords, get_word_index):
                     # real MAC address
                     pass
                 else:
-                    if _is_universal(mac):
+                    if mac and _is_universal(mac):
                         return mac
                     first_local_mac = first_local_mac or mac
     return first_local_mac or None
@@ -456,10 +458,12 @@ def _parse_mac(word):
     if len(parts) != 6:
         return
     if _MAC_OMITS_LEADING_ZEROES:
-        # (Only) on AIX the macaddr value given is not prefixed by 0, e.g.
+        # on AIX and darwin the macaddr value given is not prefixed by 0, e.g. on AIX
         # en0   1500  link#2      fa.bc.de.f7.62.4 110854824     0 160133733     0     0
         # not
         # en0   1500  link#2      fa.bc.de.f7.62.04 110854824     0 160133733     0     0
+        # and on darwin
+        # ? (224.0.0.251) at 1:0:5e:0:0:fb on en0 ifscope permanent [ethernet]
         if not all(1 <= len(part) <= 2 for part in parts):
             return
         hexstr = b''.join(part.rjust(2, b'0') for part in parts)
diff --git a/Misc/NEWS.d/next/macOS/2023-05-26-17-07-23.gh-issue-101531.xTMHTk.rst b/Misc/NEWS.d/next/macOS/2023-05-26-17-07-23.gh-issue-101531.xTMHTk.rst
new file mode 100644
index 00000000000000..20de87652fe86d
--- /dev/null
+++ b/Misc/NEWS.d/next/macOS/2023-05-26-17-07-23.gh-issue-101531.xTMHTk.rst
@@ -0,0 +1 @@
+Handle omitted leading zeroes in mac address on Darwin