diff --git a/src/wp-includes/post.php b/src/wp-includes/post.php
index 2f7cba613f0ed..993056ff2c032 100644
--- a/src/wp-includes/post.php
+++ b/src/wp-includes/post.php
@@ -8094,10 +8094,11 @@ function get_available_post_mime_types( $type = 'attachment' ) {
 	$mime_types = apply_filters( 'pre_get_available_post_mime_types', null, $type );
 
 	if ( ! is_array( $mime_types ) ) {
-		$mime_types = $wpdb->get_col( $wpdb->prepare( "SELECT DISTINCT post_mime_type FROM $wpdb->posts WHERE post_type = %s", $type ) );
+		$mime_types = $wpdb->get_col( $wpdb->prepare( "SELECT DISTINCT post_mime_type FROM $wpdb->posts WHERE post_type = %s AND post_mime_type != ''", $type ) );
 	}
 
-	return $mime_types;
+	// Remove nulls from returned $mime_types.
+	return array_values( array_filter( $mime_types ) );
 }
 
 /**
diff --git a/tests/phpunit/tests/post/getAvailablePostMimeTypes.php b/tests/phpunit/tests/post/getAvailablePostMimeTypes.php
new file mode 100644
index 0000000000000..cf6f46b920324
--- /dev/null
+++ b/tests/phpunit/tests/post/getAvailablePostMimeTypes.php
@@ -0,0 +1,58 @@
+<?php
+/**
+ * Unit tests covering post mime types.
+ *
+ * @ticket 59195
+ *
+ * @group post
+ *
+ * @covers ::get_available_post_mime_types
+ */
+
+class Tests_Post_GetAvailablePostMimeTypes extends WP_UnitTestCase {
+
+	public function tear_down() {
+		// Remove all uploads.
+		$this->remove_added_uploads();
+		remove_filter( 'pre_get_available_post_mime_types', array( $this, 'filter_add_null_to_post_mime_types' ) );
+		parent::tear_down();
+	}
+
+	public function test_should_return_expected_post_mime_types() {
+		// Upload a JPEG image.
+		$filename = DIR_TESTDATA . '/images/test-image.jpg';
+		$contents = file_get_contents( $filename );
+		$upload   = wp_upload_bits( wp_basename( $filename ), null, $contents );
+		$this->assertEmpty( $upload['error'], 'Uploading a JPEG file should not result in an error.' );
+		$this->_make_attachment( $upload );
+
+		// Upload a PDF file.
+		$filename = DIR_TESTDATA . '/images/test-alpha.pdf';
+		$contents = file_get_contents( $filename );
+		$upload   = wp_upload_bits( wp_basename( $filename ), null, $contents );
+		$this->assertEmpty( $upload['error'], 'Uploading a PDF file should not result in an error.' );
+		$this->_make_attachment( $upload );
+
+		$mime_types = get_available_post_mime_types();
+
+		$this->assertSame( array( 'image/jpeg', 'application/pdf' ), $mime_types, 'The MIME types returned should match the uploaded file MIME types.' );
+	}
+
+	public function test_should_remove_null() {
+		// Add filter to inject null into the mime types array.
+		add_filter( 'pre_get_available_post_mime_types', array( $this, 'filter_add_null_to_post_mime_types' ) );
+
+		$mime_types = get_available_post_mime_types();
+		$this->assertEqualsCanonicalizing( array( 'image/jpeg', 'image/png' ), $mime_types );
+	}
+
+	/**
+	 * Filter to inject null into the mime types array.
+	 *
+	 * @param string $type Post type.
+	 * @return array
+	 */
+	public function filter_add_null_to_post_mime_types( $type ) {
+		return array( 'image/jpeg', null, 'image/png' );
+	}
+}