Calculates gene signature scores for single-cell RNA sequencing data, using methods described in Rehman et al Cell 2021.
- Read count matrix is z-score normalized gene-wise.
- From the defined gene set and associated weights (i.e. -1 for genes anticipated to be downregulated, +1 for upregulated genes), normalized read count values belonging to the defined gene set are multiplied by the associated weight.
- Weighted read count values belonging to the gene set are averaged to derive the final signature score.