diff --git a/data/json/items/chemicals_and_resources.json b/data/json/items/chemicals_and_resources.json
index cb16caaa9b42..4aa7632a4492 100644
--- a/data/json/items/chemicals_and_resources.json
+++ b/data/json/items/chemicals_and_resources.json
@@ -276,7 +276,7 @@
     "name": { "str_sp": "commercial fertilizer" },
     "weight": "350 g",
     "color": "yellow",
-    "flags": [ "FERTILIZER" ],
+    "flags": [ "FERTILIZER", "UNSAFE_CONSUME" ],
     "use_action": "PLANTBLECH",
     "container": "bag_canvas",
     "comestible_type": "FOOD",
diff --git a/data/json/items/comestibles/carnivore.json b/data/json/items/comestibles/carnivore.json
index 31b47398ed37..aa51a313cfef 100644
--- a/data/json/items/comestibles/carnivore.json
+++ b/data/json/items/comestibles/carnivore.json
@@ -625,7 +625,7 @@
     "material": "flesh",
     "volume": "250 ml",
     "fun": -10,
-    "flags": [ "TRADER_AVOID", "SMOKABLE", "NUTRIENT_OVERRIDE", "RAW" ],
+    "flags": [ "TRADER_AVOID", "SMOKABLE", "NUTRIENT_OVERRIDE", "RAW", "UNSAFE_CONSUME" ],
     "smoking_result": "dry_meat_tainted"
   },
   {
@@ -648,7 +648,7 @@
     "volume": "250 ml",
     "milling": { "into": "meal_bone_tainted", "conversion_rate": 4 },
     "fun": -10,
-    "flags": [ "NO_SALVAGE" ]
+    "flags": [ "NO_SALVAGE", "UNSAFE_CONSUME" ]
   },
   {
     "type": "GENERIC",
@@ -678,7 +678,7 @@
     "material": "flesh",
     "volume": "250 ml",
     "fun": -10,
-    "flags": [ "RAW" ]
+    "flags": [ "RAW", "UNSAFE_CONSUME" ]
   },
   {
     "type": "COMESTIBLE",
@@ -701,7 +701,8 @@
     "volume": "250 ml",
     "charges": 2,
     "stack_size": 4,
-    "fun": -18
+    "fun": -18,
+    "flags": [ "UNSAFE_CONSUME" ]
   },
   {
     "type": "COMESTIBLE",
@@ -764,7 +765,7 @@
     "price": 330,
     "price_postapoc": 20,
     "material": "flesh",
-    "flags": [ "RAW", "TRADER_AVOID" ],
+    "flags": [ "RAW", "TRADER_AVOID", "UNSAFE_CONSUME" ],
     "stack_size": 1,
     "fun": -12
   },
@@ -819,7 +820,7 @@
     "description": "A carefully folded raw skin harvested from a fur-bearing unnatural creature.  It still has the fur attached and is poisonous.  You can cure it for storage and tanning.",
     "price": 0,
     "price_postapoc": 50,
-    "flags": [ "NO_SALVAGE" ]
+    "flags": [ "NO_SALVAGE", "UNSAFE_CONSUME" ]
   },
   {
     "type": "COMESTIBLE",
@@ -920,7 +921,8 @@
         { "id": "badpoison", "duration": 3600 },
         { "id": "shakes", "duration": 810 }
       ]
-    }
+    },
+    "flags": [ "UNSAFE_CONSUME" ]
   },
   {
     "id": "meat_bark",
diff --git a/data/json/items/comestibles/mushroom.json b/data/json/items/comestibles/mushroom.json
index 47c5c5ddfdd9..56f1489835bd 100644
--- a/data/json/items/comestibles/mushroom.json
+++ b/data/json/items/comestibles/mushroom.json
@@ -30,7 +30,7 @@
     "material": "mushroom",
     "volume": "250 ml",
     "fun": 1,
-    "flags": [ "SMOKABLE" ],
+    "flags": [ "SMOKABLE", "UNSAFE_CONSUME" ],
     "smoking_result": "dry_mushroom",
     "vitamins": [ [ "calcium", 2 ], [ "iron", 52 ] ]
   },
@@ -45,7 +45,8 @@
     "price": 1500,
     "price_postapoc": 50,
     "fun": 4,
-    "vitamins": [ [ "calcium", 2 ], [ "iron", 52 ] ]
+    "vitamins": [ [ "calcium", 2 ], [ "iron", 52 ] ],
+    "delete": { "flags": [ "UNSAFE_CONSUME" ] }
   },
   {
     "type": "COMESTIBLE",
diff --git a/data/json/items/comestibles/other.json b/data/json/items/comestibles/other.json
index 8c9fb42a5784..f1c6537dcba2 100644
--- a/data/json/items/comestibles/other.json
+++ b/data/json/items/comestibles/other.json
@@ -29,7 +29,8 @@
     "price": 0,
     "price_postapoc": 0,
     "volume": "250 ml",
-    "fun": -10
+    "fun": -10,
+    "flags": [ "UNSAFE_CONSUME" ]
   },
   {
     "type": "COMESTIBLE",
@@ -207,7 +208,8 @@
     "material": "powder",
     "volume": "250 ml",
     "charges": 4,
-    "fun": -10
+    "fun": -10,
+    "flags": [ "UNSAFE_CONSUME" ]
   },
   {
     "type": "COMESTIBLE",
@@ -568,7 +570,7 @@
     "price": 80,
     "price_postapoc": 0,
     "material": "hflesh",
-    "flags": [ "TRADER_AVOID" ],
+    "flags": [ "TRADER_AVOID", "UNSAFE_CONSUME" ],
     "volume": "250 ml",
     "fun": -30
   },
diff --git a/data/json/items/comestibles/raw_veggy.json b/data/json/items/comestibles/raw_veggy.json
index bb986ff402d1..e48c6f2d7dd4 100644
--- a/data/json/items/comestibles/raw_veggy.json
+++ b/data/json/items/comestibles/raw_veggy.json
@@ -400,7 +400,8 @@
     "material": [ "veggy" ],
     "volume": "250 ml",
     "price": 0,
-    "price_postapoc": 0
+    "price_postapoc": 0,
+    "flags": [ "UNSAFE_CONSUME" ]
   },
   {
     "type": "COMESTIBLE",
@@ -792,7 +793,8 @@
     "description": "This is a chunk of fungal matter from some sort of alien mushroom creature.  Eating unfamiliar mushrooms is a bad idea.",
     "price": 0,
     "price_postapoc": 0,
-    "smoking_result": "dry_veggy_tainted"
+    "smoking_result": "dry_veggy_tainted",
+    "extend": { "flags": [ "UNSAFE_CONSUME" ] }
   },
   {
     "type": "COMESTIBLE",
diff --git a/data/json/items/comestibles/seed.json b/data/json/items/comestibles/seed.json
index 56d452b3c3aa..af663305c16d 100644
--- a/data/json/items/comestibles/seed.json
+++ b/data/json/items/comestibles/seed.json
@@ -15,7 +15,7 @@
     "primary_material": "dried_vegetable",
     "symbol": ".",
     "color": "brown",
-    "flags": [ "NUTRIENT_OVERRIDE", "PLANTABLE_SEED" ]
+    "flags": [ "NUTRIENT_OVERRIDE", "PLANTABLE_SEED", "UNSAFE_CONSUME" ]
   },
   {
     "abstract": "seed_fruit",
@@ -318,6 +318,7 @@
     "material": "garlic",
     "volume": "150 ml",
     "fun": -3,
+    "flags": [ "UNSAFE_CONSUME" ],
     "seed_data": { "plant_name": "garlic", "fruit": "garlic", "byproducts": [ "withered" ], "grow": "10 days" }
   },
   {
@@ -382,7 +383,7 @@
     "price": 100,
     "weight": "2 g",
     "charges": 2,
-    "flags": [ "RAW" ],
+    "flags": [ "RAW", "UNSAFE_CONSUME" ],
     "seed_data": { "plant_name": "cannabis", "fruit": "cannabis", "grow": "14 days" }
   },
   {
@@ -419,6 +420,7 @@
     "volume": "100 ml",
     "stack_size": 10,
     "fun": 30,
+    "flags": [ "UNSAFE_CONSUME" ],
     "seed_data": { "fruit": "null", "//": "dummy entry, results are hardcoded", "plant_name": "marloss berry", "grow": "14 days" }
   },
   {