seminar_data.json

{"365": {"seminar_date": "Sat, Jul 18, 2020", "seminar_time": "15:00", "timezone": "Europe/Berlin", "posted": "yes", "seminar_link": "https://ocns.memberclicks.net/assets/CNS_Meetings/CNS2020/CNS2020-Keynotes.pdf", "password": "Please register at https://www.cnsorg.org/cns-2020. The system will email you the password for the Sched.com, where you get the link to the talk.", "video_on_demand": "", "speaker_title": "Director of Neuroscience Research", "seminar_speaker": "Matt Botvinick", "speaker_affil": "DeepMind", "speaker_twitter": "@CNSorg", "speaker_website": "https://scholar.google.com/citations?user=eM916YMAAAAJ&hl=en", "topic_tags": "computational neuroscience, deep learning, reinforcement learning", "seminar_title": "Deep reinforcement learning and its neuroscientific implications", "seminar_abstract": "The last few years have seen some dramatic developments in artificial intelligence research. What implications might these have for neuroscience? Investigations of this question have, to date, focused largely on deep neural networks trained using supervised learning, in tasks such as image classification. However, there is another area of recent AI work which has so far received less attention from neuroscientists, but which may have more profound neuroscientific implications: Deep reinforcement learning. Deep RL offers a rich framework for studying the interplay among learning, representation and decision-making, offering to the brain sciences a new set of research tools and a wide range of novel hypotheses. I\u2019ll provide a high level introduction to deep RL, discuss some recent neuroscience-oriented investigations from my group at DeepMind, and survey some wider implications for research on brain and behavior.", "hosted_by": "CNS 2020", "domain": ["Neuroscience"], "calendar_event_hash": "227c5ea55432074b198c3de70d396da0fadb671162d22e9858b2fb2b15f0baf4", "seminar_id": 365, "time_of_addition": "Thu, Jul 16, 2020 15:55"}, "366": {"seminar_date": "Sun, Jul 19, 2020", "seminar_time": "15:00", "timezone": "Europe/Berlin", "posted": "yes", "seminar_link": "https://ocns.memberclicks.net/assets/CNS_Meetings/CNS2020/CNS2020-Keynotes.pdf", "password": "Please register at https://www.cnsorg.org/cns-2020. The system will email you the password for the Sched.com, where you get the link to the talk.", "video_on_demand": "", "speaker_title": "Prof.", "seminar_speaker": "Zhaoping Li", "speaker_affil": "University of Tuebingen and Max Planck Institute", "speaker_twitter": "@CNSorg", "speaker_website": "https://www.kyb.tuebingen.mpg.de/sensory-and-sensorimotor-systems", "topic_tags": "computational neuroscience, vision, cortex", "seminar_title": "A new computational framework for understanding vision in our brain", "seminar_abstract": "Visual attention selects only a tiny fraction of visual input information for further processing. Selection starts in the primary visual cortex (V1), which creates a bottom-up saliency map to guide the fovea to selected visual locations via gaze shifts. This motivates a new framework that views vision as consisting of encoding, selection, and decoding stages, placing selection on center stage. It suggests a massive loss of non-selected information from V1 downstream along the visual pathway. Hence, feedback from downstream visual cortical areas to V1 for better decoding (recognition), through analysis-by- synthesis, should query for additional information and be mainly directed at the foveal region. Accordingly, non-foveal vision is not only poorer in spatial resolution, but also more susceptible to many illusions.", "hosted_by": "CNS 2020", "domain": ["Neuroscience"], "calendar_event_hash": "25be7ee657605ccff04cbef1fe03dcc69a0f65a21be8b96b716d3bfa0866eb61", "seminar_id": 366, "time_of_addition": "Thu, Jul 16, 2020 15:55"}, "367": {"seminar_date": "Sun, Jul 19, 2020", "seminar_time": "13:00:00 PM", "timezone": "Europe/Berlin", "posted": "yes", "seminar_link": "https://ocns.memberclicks.net/assets/CNS_Meetings/CNS2020/CNS2020-Featured-talks.pdf", "password": "Please register at https://www.cnsorg.org/cns-2020. The system will email you the password for the Sched.com, where you get the link to the talk.", "video_on_demand": "", "speaker_title": "", "seminar_speaker": "Xiaoliu Zhang", "speaker_affil": "Monash University", "speaker_twitter": "@CNSorg", "speaker_website": "", "topic_tags": "computational neuroscience", "seminar_title": "Delineating Reward/Avoidance Decision Process in the Impulsive-compulsive Spectrum Disorders through a Probabilistic Reversal Learning Task", "seminar_abstract": "Impulsivity and compulsivity are behavioural traits that underlie many aspects of decision-making and form the characteristic symptoms of Obsessive Compulsive Disorder (OCD) and Gambling Disorder (GD). The neural underpinnings of aspects of reward and avoidance learning under the expression of these traits and symptoms are only partially understood. \" \"The present study combined behavioural modelling and neuroimaging technique to examine brain activity associated with critical phases of reward and loss processing in OCD and GD. \" \"Forty-two healthy controls (HC), forty OCD and twenty-three GD participants were recruited in our study to complete a two-session reinforcement learning (RL) task featuring a \u201cprobability switch (PS)\u201d with imaging scanning. Finally, 39 HC (20F/19M, 34 yrs +/- 9.47), 28 OCD (14F/14M, 32.11 yrs \u00b19.53) and 16 GD (4F/12M, 35.53yrs \u00b1 12.20) were included with both behavioural and imaging data available. The functional imaging was conducted by using 3.0-T SIEMENS MAGNETOM Skyra syngo MR D13C at Monash Biomedical Imaging. Each volume compromised 34 coronal slices of 3 mm thickness with 2000 ms TR and 30 ms TE. A total of 479 volumes were acquired for each participant in each session in an interleaved-ascending manner. \" \" The standard Q-learning model was fitted to the observed behavioural data and the Bayesian model was used for the parameter estimation. Imaging analysis was conducted using SPM12 (Welcome Department of Imaging Neuroscience, London, United Kingdom) in the Matlab (R2015b) environment. The pre-processing commenced with the slice timing, realignment, normalization to MNI space according to T1-weighted image and smoothing with a 8 mm Gaussian kernel. \" \" The frontostriatal brain circuit including the putamen and medial orbitofrontal (mOFC) were significantly more active in response to receiving reward and avoiding punishment compared to receiving an aversive outcome and missing reward at 0.001 with FWE correction at cluster level; While the right insula showed greater activation in response to missing rewards and receiving punishment. Compared to healthy participants, GD patients showed significantly lower activation in the left superior frontal and posterior cingulum at  0.001 for the gain omission. \" \" The reward prediction error (PE) signal was found positively correlated with the activation at several clusters expanding across cortical and subcortical region including the striatum, cingulate, bilateral insula, thalamus and superior frontal at  0.001 with FWE correction at cluster level. The GD patients showed a trend of decreased reward PE response in the right precentral extending to left posterior cingulate compared to controls at 0.05 with FWE correction. \" \" The aversive PE signal was negatively correlated with brain activity in regions including bilateral thalamus, hippocampus, insula and striatum at 0.001 with FWE correction.  Compared with the control group, GD group showed an increased aversive PE activation in the cluster encompassing right thalamus and right hippocampus, and also the right middle frontal extending to the right anterior cingulum at 0.005 with FWE correction. \" \" Through the reversal learning task, the study provided a further support of the dissociable brain circuits for distinct phases of reward and avoidance learning. Also, the OCD and GD is characterised by aberrant patterns of reward and avoidance processing.", "hosted_by": "CNS 2020", "domain": ["Neuroscience"], "calendar_event_hash": "c151dc33c3fb33059eda3d151208c6967b86bac20ba6d7dd91a8057cfa33da59", "seminar_id": 367, "time_of_addition": "Thu, Jul 16, 2020 15:55"}, "368": {"seminar_date": "Sun, Jul 19, 2020", "seminar_time": "17:40:00 PM", "timezone": "Europe/Berlin", "posted": "yes", "seminar_link": "https://ocns.memberclicks.net/assets/CNS_Meetings/CNS2020/CNS2020-Featured-talks.pdf", "password": "Please register at https://www.cnsorg.org/cns-2020. The system will email you the password for the Sched.com, where you get the link to the talk.", "video_on_demand": "", "speaker_title": "", "seminar_speaker": "Andrea Navas-Olive", "speaker_affil": "Instituto Cajal CSIC", "speaker_twitter": "@CNSorg", "speaker_website": "", "topic_tags": "computational neuroscience", "seminar_title": "Using evolutionary algorithms to explore single-cell heterogeneity and microcircuit operation in the hippocampus", "seminar_abstract": "The hippocampus-entorhinal system is critical for learning and memory. Recent cutting-edge single-cell technologies from RNAseq to electrophysiology are disclosing a so far unrecognized heterogeneity within the major cell types (1). Surprisingly, massive high-throughput recordings of these very same cells identify low dimensional microcircuit dynamics (2,3). Reconciling both views is critical to understand how the brain operates. \" \"The CA1 region is considered high in the hierarchy of the entorhinal-hippocampal system. Traditionally viewed as a single layered structure, recent evidence has disclosed an exquisite laminar organization across deep and superficial pyramidal sublayers at the transcriptional, morphological and functional levels (1,4,5). Such a low-dimensional segregation may be driven by a combination of intrinsic, biophysical and microcircuit factors but mechanisms are unknown.\" \"Here, we exploit evolutionary algorithms to address the effect of single-cell heterogeneity on CA1 pyramidal cell activity (6). First, we developed a biophysically realistic model of CA1 pyramidal cells using the Hodgkin-Huxley multi-compartment formalism in the Neuron+Python platform and the morphological database Neuromorpho.org. We adopted genetic algorithms (GA) to identify passive, active and synaptic conductances resulting in realistic electrophysiological behavior. We then used the generated models to explore the functional effect of intrinsic, synaptic and morphological heterogeneity during oscillatory activities. By combining results from all simulations in a logistic regression model we evaluated the effect of up/down-regulation of different factors. We found that muyltidimensional excitatory and inhibitory inputs interact with morphological and intrinsic factors to determine a low dimensional subset of output features (e.g. phase-locking preference) that matches non-fitted experimental data.", "hosted_by": "CNS 2020", "domain": ["Neuroscience"], "calendar_event_hash": "596c19239e5ccecac02712a36b0cbcbbffa73f11831003cdb1d98941de5271f4", "seminar_id": 368, "time_of_addition": "Thu, Jul 16, 2020 15:55"}, "369": {"seminar_date": "Mon, Jul 20, 2020", "seminar_time": "13:00:00 PM", "timezone": "Europe/Berlin", "posted": "yes", "seminar_link": "https://ocns.memberclicks.net/assets/CNS_Meetings/CNS2020/CNS2020-Featured-talks.pdf", "password": "Please register at https://www.cnsorg.org/cns-2020. The system will email you the password for the Sched.com, where you get the link to the talk.", "video_on_demand": "", "speaker_title": "", "seminar_speaker": "Adriano Bellotti", "speaker_affil": "University of Cambridge", "speaker_twitter": "@CNSorg", "speaker_website": "", "topic_tags": "computational neuroscience", "seminar_title": "Neuronal morphology imposes a tradeoff between stability, accuracy and efficiency of synaptic scaling", "seminar_abstract": "Synaptic scaling is a homeostatic normalization mechanism that preserves relative synaptic strengths by adjusting them with a common factor. This multiplicative change is believed to be critical, since synaptic strengths are involved in learning and memory retention. Further, this homeostatic process is thought to be crucial for neuronal stability, playing a stabilizing role in otherwise runaway Hebbian plasticity [1-3]. Synaptic scaling requires a mechanism to sense total neuron activity and globally adjust synapses to achieve some activity set-point [4]. This process is relatively slow, which places limits on its ability to stabilize network activity [5]. Here we show that this slow response is inevitable in realistic neuronal morphologies. Furthermore, we reveal that global scaling can in fact be a source of instability unless responsiveness or scaling accuracy are sacrificed.\"  \"A neuron with tens of thousands of synapses must regulate its own excitability to compensate for changes in input. The time requirement for global feedback can introduce critical phase lags in a neuron\u2019s response to perturbation. The severity of phase lag increases with neuron size. Further, a more expansive morphology worsens cell responsiveness and scaling accuracy, especially in distal regions of the neuron. Local pools of reserve receptors improve efficiency, potentiation, and scaling, but this comes at a cost. Trafficking large quantities of receptors requires time, exacerbating the phase lag and instability. Local homeostatic feedback mitigates instability, but this too comes at the cost of reducing scaling accuracy.\"  \"Realization of the phase lag instability requires a unified model of synaptic scaling, regulation, and transport. We present such a model with global and local feedback in realistic neuron morphologies (Fig. 1). This combined model shows that neurons face a tradeoff between stability, accuracy, and efficiency. Global feedback is required for synaptic scaling but favors either system stability or efficiency. Large receptor pools improve scaling accuracy in large morphologies but worsen both stability and efficiency. Local feedback improves the stability-efficiency tradeoff at the cost of scaling accuracy. This project introduces unexplored constraints on neuron size, morphology, and synaptic scaling that are weakened by an interplay between global and local feedback.", "hosted_by": "CNS 2020", "domain": ["Neuroscience"], "calendar_event_hash": "2c699ecd00e1a344ce7da7b40f5bf6b545320fe0ca7bf275d3f5ff9141dc522d", "seminar_id": 369, "time_of_addition": "Thu, Jul 16, 2020 15:55"}, "370": {"seminar_date": "Mon, Jul 20, 2020", "seminar_time": "15:00", "timezone": "Europe/Berlin", "posted": "yes", "seminar_link": "https://ocns.memberclicks.net/assets/CNS_Meetings/CNS2020/CNS2020-Keynotes.pdf", "password": "Please register at https://www.cnsorg.org/cns-2020. The system will email you the password for the Sched.com, where you get the link to the talk.", "video_on_demand": "", "speaker_title": "Prof.", "seminar_speaker": "Daniel Polani", "speaker_affil": "University of Hertfordshire", "speaker_twitter": "@CNSorg", "speaker_website": "http://homepages.herts.ac.uk/~comqdp1/", "topic_tags": "computational neuroscience, information, decision making", "seminar_title": "Information and Decision-Making", "seminar_abstract": "In recent years it has become increasingly clear that (Shannon) information is a central resource for organisms, akin in importance to energy. Any decision that an organism or a subsystem of an organism takes involves the acquisition, selection, and processing of information and ultimately its concentration and enaction. It is the consequences of this balance that will occupy us in this talk. This perception-action loop picture of an agent's life cycle is well established and expounded especially in the context of Fuster's sensorimotor hierarchies. Nevertheless, the information-theoretic perspective drastically expands the potential and predictive power of the perception-action loop perspective. On the one hand information can be treated - to a significant extent - as a resource that is being sought and utilized by an organism. On the other hand, unlike energy, information is not additive. The intrinsic structure and dynamics of information can be exceedingly complex and subtle; in the last two decades one has discovered that Shannon information possesses a rich and nontrivial intrinsic structure that must be taken into account when informational contributions, information flow or causal interactions of processes are investigated, whether in the brain or in other complex processes. In addition, strong parallels between information and control theory have emerged. This parallelism between the theories allows one to obtain unexpected insights into the nature and properties of the perception-action loop. Through the lens of information theory, one can not only come up with novel hypotheses about necessary conditions for the organization of information processing in a brain, but also with constructive conjectures and predictions about what behaviours, brain structure and dynamics and even evolutionary pressures one can expect to operate on biological organisms, induced purely by informational considerations.", "hosted_by": "CNS 2020", "domain": ["Neuroscience"], "calendar_event_hash": "65906f672224593aa431045d157ec1b72d36cdb4ed48510bd9e766af21f20e89", "seminar_id": 370, "time_of_addition": "Thu, Jul 16, 2020 15:55"}, "371": {"seminar_date": "Mon, Jul 20, 2020", "seminar_time": "16:20:00 PM", "timezone": "Europe/Berlin", "posted": "yes", "seminar_link": "https://ocns.memberclicks.net/assets/CNS_Meetings/CNS2020/CNS2020-Featured-talks.pdf", "password": "Please register at https://www.cnsorg.org/cns-2020. The system will email you the password for the Sched.com, where you get the link to the talk.", "video_on_demand": "", "speaker_title": "", "seminar_speaker": "Ioannis Pisokas", "speaker_affil": "University of Edinburgh", "speaker_twitter": "@CNSorg", "speaker_website": "", "topic_tags": "computational neuroscience", "seminar_title": "Who can turn faster? Comparison of the head direction circuit of two species", "seminar_abstract": "Ants, bees and other insects have the ability to return to their nest or hive using a navigation strategy known as path integration. Similarly, fruit flies employ path integration to return to a previously visited food source. An important component of path integration is the ability of the insect to keep track of its heading relative to salient visual cues. A highly conserved brain region known as the central complex has been identified as being of key importance for the computations required for an insect to keep track of its heading. However, the similarities or differences of the underlying heading tracking circuit between species are not well understood. We sought to address this shortcoming by using reverse engineering techniques to derive the effective underlying neural circuits of two evolutionary distant species, the fruit fly and the locust. Our analysis revealed that regardless of the anatomical differences between the two species the essential circuit structure has not changed. Both effective neural circuits have the structural topology of a ring attractor with an eight-fold radial symmetry (Fig. 1). However, despite the strong similarities between the two ring attractors, there remain differences. Using computational modelling we found that two apparently small anatomical differences have significant functional effect on the ability of the two circuits to track fast rotational movements and to maintain a stable heading signal. In particular, the fruit fly circuit responds faster to abrupt heading changes of the animal while the locust circuit maintains a heading signal that is more robust to inhomogeneities in cell membrane properties and synaptic weights. We suggest that the effects of these differences are consistent with the behavioural ecology of the two species. On the one hand, the faster response of the ring attractor circuit in the fruit fly accommodates the fast body saccades that fruit flies are known to perform. On the other hand, the locust is a migratory species, so its behaviour demands maintenance of a defined heading for a long period of time. Our results highlight that even seemingly small differences in the distribution of dendritic fibres can have a significant effect on the dynamics of the effective ring attractor circuit with consequences for the behavioural capabilities of each species. These differences, emerging from morphologically distinct single neurons highlight the importance of a comparative approach to neuroscience.", "hosted_by": "CNS 2020", "domain": ["Neuroscience"], "calendar_event_hash": "662fd6dba1ba52efae2f3d7428bef001708e8e65837f1383f6efbc0d7c2810cd", "seminar_id": 371, "time_of_addition": "Thu, Jul 16, 2020 15:55"}, "372": {"seminar_date": "Tue, Jul 21, 2020", "seminar_time": "7:00", "timezone": "Europe/Berlin", "posted": "yes", "seminar_link": "https://ocns.memberclicks.net/assets/CNS_Meetings/CNS2020/CNS2020-Keynotes.pdf", "password": "Please register at https://www.cnsorg.org/cns-2020. The system will email you the password for the Sched.com, where you get the link to the talk.", "video_on_demand": "", "speaker_title": "Prof.", "seminar_speaker": "Geoffrey J. Goodhill", "speaker_affil": "The University of Queensland", "speaker_twitter": "@CNSorg", "speaker_website": "https://qbi.uq.edu.au/profile/553/geoffrey-goodhill", "topic_tags": "computational neuroscience, neural development", "seminar_title": "Computational models of neural development", "seminar_abstract": "Unlike even the most sophisticated current forms of artificial intelligence, developing biological organisms must build their neural hardware from scratch. Furthermore they must start to evade predators and find food before this construction process is complete. I will discuss an interdisciplinary program of mathematical and experimental work which addresses some of the computational principles underlying neural development. This includes (i) how growing axons navigate to their targets by detecting and responding to molecular cues in their environment, (ii) the formation of maps in the visual cortex and how these are influenced by visual experience, and (iii) how patterns of neural activity in the zebrafish brain develop to facilitate precisely targeted hunting behaviour. Together this work contributes to our understanding of both normal neural development and the etiology of neurodevelopmental disorders.", "hosted_by": "CNS 2020", "domain": ["Neuroscience"], "calendar_event_hash": "eab0b214687723518a9c896076891da2b8436a2030ea8bc9aca0c9d0a1a2e20e", "seminar_id": 372, "time_of_addition": "Thu, Jul 16, 2020 15:55"}, "356": {"seminar_date": "Wed, Jul 15, 2020", "seminar_time": "14:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://www.eventbrite.com/e/ucl-neuroai-talk-series-tickets-112577317788?aff=eemailordconf&utm_campaign=order_confirm&utm_medium=email&ref=eemailordconf&utm_source=eventbrite&utm_term=viewevent", "password": "", "video_on_demand": "", "speaker_title": "Dr", "seminar_speaker": "Irina Higgins", "speaker_affil": "Google Deepmind", "speaker_twitter": "", "speaker_website": "", "topic_tags": "NeuroAI", "seminar_title": "Unsupervised deep learning identifies semantic disentanglement in single inferotemporal neurons", "seminar_abstract": "Irina is a research scientist at DeepMind, where she works in the Froniers team. Her work aims to bring together insights from the fields of neuroscience and physics to advance general artificial intelligence through improved representation learning. Before joining DeepMind, Irina was a British Psychological Society Undergraduate Award winner for her achievements as an undergraduate student in Experimental Psychology at Westminster University, followed by a DPhil at the Oxford Centre for Computational Neuroscience and Artificial Intelligence, where she focused on understanding the computational principles underlying speech processing in the auditory brain. During her DPhil, Irina also worked on developing poker AI, applying machine learning in the finance sector, and working on speech recognition at Google Research.\"\"  https://arxiv.org/pdf/2006.14304.pdf", "hosted_by": "NeuroAI UCL", "domain": ["Neuroscience"], "calendar_event_hash": "1346197f91766b1444df275aa8e35904fc16402386549a5947a61f2451007250", "seminar_id": 356, "time_of_addition": "Mon, Jul 13, 2020 12:35"}, "642": {"seminar_date": "Wed, Sep 16, 2020", "seminar_time": "14:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://www.eventbrite.com/e/ucl-neuroai-talk-series-tickets-115333525680", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Michael Bronstein", "speaker_affil": "Imperial College London", "speaker_twitter": "", "speaker_website": "", "topic_tags": "NeuroAI", "seminar_title": "Geometric deep learning on graphs and manifolds", "seminar_abstract": "", "hosted_by": "NeuroAI UCL", "domain": ["Neuroscience"], "calendar_event_hash": "80c333d75fbd66b1196836456ec4dbd4da4473a8e09142359290fe216e698e46", "seminar_id": 642, "time_of_addition": "Fri, Sep 11, 2020 12:40"}, "928": {"seminar_date": "Thu, Apr 30, 2020", "seminar_time": "16:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://t.co/T7FF9f3bm6?amp=1", "password": "", "video_on_demand": "https://www.youtube.com/watch?v=S6Dxzajz5iM", "speaker_title": "Sir Prof", "seminar_speaker": "David Klenerman", "speaker_affil": "University of Cambridge", "speaker_twitter": "@UKDRI", "speaker_website": "https://www.ch.cam.ac.uk/person/dk10012", "topic_tags": "disease", "seminar_title": "Watching single molecules in action: How this can be used in neurodegeneration", "seminar_abstract": "This talk aims to show how new physical methods can advance biological and biomedical research.  A major advance in physical chemistry in the last two decades has been the development of quantitative methods to directly observe individual molecules in solution, attached to surfaces, in the membrane of live cells or more recently inside live cells. These single-molecule fluorescence studies have now reached a stage where they can provide new insights into important biological problems. After presenting the principles of these methods, I will give some examples from our current research to probe the molecular basis of neurodegeneration. Here we have used single-molecule fluorescence to detect and analyse the low concentrations of soluble protein aggregates thought to be responsible for Alzheimer\u2019s disease and determine the mechanisms by which they damage neurons. Lastly, I will describe how fundamental science aimed at watching single molecules incorporating nucleotides into DNA gave rise to a new rapid method to sequence DNA that is now widely used.", "hosted_by": "SONA", "domain": ["Neuroscience"], "calendar_event_hash": "9fff4998cfbf60ee6319857186c8ad83ec99187a413f71ca166c213a77950f46", "seminar_id": 928, "time_of_addition": "Mon, Sep 28, 2020 11:08"}, "929": {"seminar_date": "Tue, May 12, 2020", "seminar_time": "16:00", "timezone": "Europe/London", "posted": "Yes", "seminar_link": "https://www.youtube.com/watch?v=bsPmLF65r3k", "password": "", "video_on_demand": "https://youtu.be/bsPmLF65r3k", "speaker_title": "", "seminar_speaker": "Andr\u00e9 Maia Chagas", "speaker_affil": "University of Sussex", "speaker_twitter": "@Chagas_AM", "speaker_website": "https://amchagas.github.io/", "topic_tags": "open neuroscience", "seminar_title": "Open Neuroscience: Challenging scientific barriers with Open Source & Open Science tools", "seminar_abstract": "The Open Science movement advocates for more transparent, equitable and reliable science. It focusses on improving existing infrastructures and spans all aspects of the scientific process, from implementing systems that reward pre-registering studies and guarantee their publication, all the way to making research data citable and freely available. In this context, open source tools (and the development ethos supporting them) are becoming more and more present in academic labs, as researchers are realizing that they can improve the quality of their work, while cutting costs. In this talk an overview of OS tools for neuroscience will be given, with a focus on software and hardware, and how their use can bring scientific independence and make research evolve faster.", "hosted_by": "SONA", "domain": ["Neuroscience"], "calendar_event_hash": "cbe4ff24f14185a95ea5b563c460c7ea41ab1e8c28b68effee3e971b81303ba6", "seminar_id": 929, "time_of_addition": "Mon, Sep 28, 2020 11:08"}, "930": {"seminar_date": "Fri, May 22, 2020", "seminar_time": "16:00", "timezone": "Europe/London", "posted": "Yes", "seminar_link": "https://www.youtube.com/watch?v=DPb4jkqtJT4", "password": "", "video_on_demand": "https://www.youtube.com/watch?v=DPb4jkqtJT4", "speaker_title": "Prof", "seminar_speaker": "James O Olopade", "speaker_affil": "University of Ibadan", "speaker_twitter": "@SONAorg", "speaker_website": "https://sonafrica.org/", "topic_tags": "neuroanatomy, neurogenesis, neurodegeneration", "seminar_title": "Neuroscience Investigations in the Virgin Lands of African Biodiversity", "seminar_abstract": "Africa is blessed with a rich diversity and abundance in rodent and avian populations. This natural endowment on the continent portends research opportunities to study unique anatomical profiles and investigate animal models that may confer better neural architecture to study neurodegenerative diseases, adult neurogenesis, stroke and stem cell therapies. To this end, African researchers are beginning to pay closer attention to some of her indigenous rodents and birds in an attempt to develop spontaneous laboratory models for homegrown neuroscience-based research. For this presentation, I will be showing studies in our lab, involving cellular neuroanatomy of two rodents, the African giant rat (AGR) and Greater cane rat (GCR), Eidolon Bats (EB) and also the Striped Owl (SO). Using histological stains (Cresyl violet and Rapid Golgi) and immunohistochemical biomarkers (GFAP, NeuN, CNPase, Iba-1, Collagen 2, Doublecortin, Ki67, Calbindin, etc), and Electron Microscopy, morphology and functional organizations of neuronal and glial populations of the AGR , GCR, EB and SO brains have been described, with our work ongoing. In addition, the developmental profiles of the prenatal GCR brains have been chronicled across its entire gestational period. Brains of embryos/foetuses were harvested for gross morphological descriptions and then processed using immunofluorescence biomarkers to determine the pattern, onset, duration and peak of neurogenesis (Pax6, Tbr1, Tbr2, NF, HuCD, MAP2) and the onset and peak of glial cell expressions and myelination in the prenatal GCR. The outcome of these research efforts has shown unique neuroanatomical expressions and networks amongst Africa\u2019s rich biodiversity. It is hopeful that continuous effort in this regard will provide sufficient basic research data on neural developments and cellular neuroanatomy with subsequent translational consequences.", "hosted_by": "SONA", "domain": ["Neuroscience"], "calendar_event_hash": "b558a19b8a0fb7a760fd9315cd3a01d8a7e99ba932768c3273380fc38e5c2c22", "seminar_id": 930, "time_of_addition": "Mon, Sep 28, 2020 11:08"}, "351": {"seminar_date": "Fri, Jul 17, 2020", "seminar_time": "16:00", "timezone": "Europe/London", "posted": "Yes", "seminar_link": "https://ucl.zoom.us/webinar/register/4715943201707/WN_17n6gvghSmutWquSJZ5vmA", "password": "", "video_on_demand": "https://www.youtube.com/watch?v=Gm-OinnVDP4&t=252s", "speaker_title": "Dr", "seminar_speaker": "Mahmoud Bukar Maina", "speaker_affil": "University of Sussex", "speaker_twitter": "@SONAorg", "speaker_website": "https://sonafrica.org/", "topic_tags": "open neuroscience", "seminar_title": "African Neuroscience: Current Status and Prospects", "seminar_abstract": "Understanding the function and dysfunction of the brain remains one of the key challenges of our time. However, an overwhelming majority of brain research is carried out in the Global North, by a minority of well-funded and intimately interconnected labs. In contrast, with an estimated one neuroscientist per million people in Africa, news about neuroscience research from the Global South remains sparse. Clearly, devising new policies to boost Africa\u2019s neuroscience landscape is imperative. However, the policy must be based on accurate data, which is largely lacking. Such data must reflect the extreme heterogeneity of research outputs across the continent\u2019s 54 countries. We have analysed all of Africa\u2019s Neuroscience output over the past 21 years and uniquely verified the work performed in African laboratories. Our unique dataset allows us to gain accurate and in-depth information on the current state of African Neuroscience research, and to put it into a global context. The key findings from this work and recommendations on how African research might best be supported in the future will be discussed.", "hosted_by": "SONA", "domain": ["Neuroscience"], "calendar_event_hash": "89379f8bba92a293a546b0ae1e2a8ae5067257f581afa97d3c5804a11cc3faff", "seminar_id": 351, "time_of_addition": "Thu, Jul 09, 2020 21:45"}, "931": {"seminar_date": "Thu, Jul 23, 2020", "seminar_time": "16:00", "timezone": "Europe/London", "posted": "Yes", "seminar_link": "https://ucl.zoom.us/webinar/register/6315909451274/WN_SqutehmXTCWTP35psPHTGw", "password": "", "video_on_demand": "https://www.youtube.com/watch?v=EYUuOLlyNjk&t=18s", "speaker_title": "Prof", "seminar_speaker": "Karen Duff", "speaker_affil": "UK Dementia Research Institute at UCL", "speaker_twitter": "@SONAorg", "speaker_website": "https://ukdri.ac.uk/team/karen-duff", "topic_tags": "neurodegeneration, dementia", "seminar_title": "Mechanisms of pathogenesis in the tauopathies", "seminar_abstract": "The distribution of pathological tau in the brain of patients with AD is highly predicable, and as disease worsens, it spreads transynaptically from initial regions of vulnerability. The reason why only some neurons are vulnerable to the accumulation and propagation of pathological forms of tau, and the mechanisms by which tauopathy spreads through the brain are not well understood. Using a combination of immunohistochemistry and computational analysis we have examined pathway differences between vulnerable and resistant neurons. How tau spreads across a synapse has been examined in vitro using different model systems. Our data show that dysregulation of tau homeostasis determines the cellular and regional vulnerability of specific neurons to tau pathology (H. Fu et al. 2019. Nat. Neuro. 22 (1):47-56) and that deficits in tau homeostasis can exacerbate tau accumulation and propagation. Aging appears to impact similar neuronal populations. Mechanisms and consequences of abnormal tau accumulation within neurons, its transfer between cells, pathology propagation and therapeutic opportunities will be discussed.", "hosted_by": "SONA", "domain": ["Neuroscience"], "calendar_event_hash": "2c0a186a4281ca2804ccbc874937ffc1d373fc457a2d2e34b9cf10d2462f160c", "seminar_id": 931, "time_of_addition": "Mon, Sep 28, 2020 11:08"}, "352": {"seminar_date": "Thu, Jul 30, 2020", "seminar_time": "16:00", "timezone": "Europe/London", "posted": "Yes", "seminar_link": "https://ucl.zoom.us/webinar/register/4715936421528/WN_YaUZL_nyRVyCFKrCyiy_aQ", "password": "", "video_on_demand": "https://www.youtube.com/watch?v=NIsvdcgUBpg&t=15s", "speaker_title": "Dr", "seminar_speaker": "Martin Kampmann", "speaker_affil": "UCSF Department of Biochemistry and Biophysics", "speaker_twitter": "@SONAorg", "speaker_website": "https://kampmannlab.ucsf.edu/martin-kampmann-phd", "topic_tags": "genetics, neurodegeneration", "seminar_title": "CRISPR-based functional genomics in iPSC-based models of brain disease", "seminar_abstract": "Human genes associated with brain-related diseases are being discovered at an accelerating pace. A major challenge is an identification of the mechanisms through which these genes act, and of potential therapeutic strategies. To elucidate such mechanisms in human cells, we established a CRISPR-based platform for genetic screening in human iPSC-derived neurons, astrocytes and microglia. Our approach relies on CRISPR interference (CRISPRi) and CRISPR activation (CRISPRa), in which a catalytically dead version of the bacterial Cas9 protein recruits transcriptional repressors or activators, respectively, to endogenous genes to control their expression, as directed by a small guide RNA (sgRNA). Complex libraries of sgRNAs enable us to conduct genome-wide or focused loss-of-function and gain-of-function screens. Such screens uncover molecular players for phenotypes based on survival, stress resistance, fluorescent phenotypes, high-content imaging and single-cell RNA-Seq. To uncover disease mechanisms and therapeutic targets, we are conducting genetic modifier screens for disease-relevant cellular phenotypes in patient-derived neurons and glia with familial mutations and isogenic controls. In a genome-wide screen, we have uncovered genes that modulate the formation of disease-associated aggregates of tau in neurons with a tauopathy-linked mutation (MAPT V337M). CRISPRi/a can also be used to model and functionally evaluate disease-associated changes in gene expression, such as those caused by eQTLs, haploinsufficiency, or disease states of brain cells. We will discuss an application to Alzheimer\u2019s Disease-associated genes in microglia.", "hosted_by": "SONA", "domain": ["Neuroscience"], "calendar_event_hash": "1560fecb8714922ab08a7261a1307df183881db07ffc9a5dfe0ef3cb092eb814", "seminar_id": 352, "time_of_addition": "Thu, Jul 09, 2020 21:45"}, "353": {"seminar_date": "Thu, Aug 6, 2020", "seminar_time": "16:00", "timezone": "Europe/London", "posted": "Yes", "seminar_link": "https://ucl.zoom.us/webinar/register/4115938122250/WN_DnSq04yVQcmhgk8bJjO-Rw", "password": "", "video_on_demand": "", "speaker_title": "Dr", "seminar_speaker": "Soyon Hong", "speaker_affil": "UK Dementia Research Institute at UCL", "speaker_twitter": "@SONAorg", "speaker_website": "https://ukdri.ac.uk/team/soyon-hong", "topic_tags": "neurodegeneration, dementia, microglia", "seminar_title": "More than Bystanders in Dementia, Learning What Microglia Do", "seminar_abstract": "Genome-wide association studies implicate microglia in Alzheimer\u2019s disease (AD) pathogenesis, but how microglia contribute to cognitive decline in AD is unclear. Emerging research suggests microglia, the resident macrophages of the central nervous system, to be active participants in brain wiring. One mechanism by which microglia help eliminate synapses is through the classical complement pathway (C1q, CR3/C3). Data from multiple laboratories collectively suggest that there may be an aberrant reactivation of the complement-dependent pruning pathway in multiple models of neurologic diseases including AD. These data altogether suggest that microglia participate in synaptic pathology. However, how and which synapses are targeted are unknown. Furthermore, whether microglia directly impair synaptic function is unknown. Primary goals of my laboratory are to understand how higher cognitive functions such as learning and memory involve microglial biology in the healthy adult brain and dissect immune mechanisms behind the region-specific vulnerability of synapse loss and neuronal dysfunction during disease. Mechanistic insight into local signals that regulate neuroglia interactions will be key to developing potential therapeutic avenues to target in disease.", "hosted_by": "SONA", "domain": ["Neuroscience"], "calendar_event_hash": "b28e4057dbe72c5dd31525dd64a05a3e52eabc1a51edeb9267e575508f4c07a8", "seminar_id": 353, "time_of_addition": "Thu, Jul 09, 2020 21:50"}, "381": {"seminar_date": "Thu, Aug 20, 2020", "seminar_time": "16:00", "timezone": "Europe/London", "posted": "Yes", "seminar_link": "https://ucl.zoom.us/webinar/register/5315951882356/WN_mEO0BKPpSF-RwrExZEwZjw", "password": "", "video_on_demand": "https://www.youtube.com/watch?v=sscadeXGj2Q", "speaker_title": "Dr", "seminar_speaker": "Joanne Kamens", "speaker_affil": "Addgene", "speaker_twitter": "@SONAorg", "speaker_website": "https://www.linkedin.com/in/joannekamens/", "topic_tags": "", "seminar_title": "Academia, Pharma, Biotech, Nonprofit - Career transitions in Science", "seminar_abstract": "", "hosted_by": "SONA", "domain": ["Neuroscience"], "calendar_event_hash": "27a74bea6e7f8b4729c7f6da15ca90b993889ed819b0712f81e4fd5e8a81c5d7", "seminar_id": 381, "time_of_addition": "Sun, Jul 19, 2020 21:00"}, "582": {"seminar_date": "Thu, Sep 17, 2020", "seminar_time": "16:00", "timezone": "Europe/London", "posted": "Yes", "seminar_link": "https://ucl.zoom.us/webinar/register/7015991719414/WN_ryAk4k5DRFCleNuboLJ2Zg", "password": "", "video_on_demand": "", "speaker_title": "Dr", "seminar_speaker": "Helena Ledmyr", "speaker_affil": "INCF", "speaker_twitter": "@SONAorg", "speaker_website": "https://www.incf.org/team/helena-ledmyr", "topic_tags": "open neuroscience", "seminar_title": "INCF: enabling open and FAIR neuroscience", "seminar_abstract": "", "hosted_by": "SONA", "domain": ["Neuroscience"], "calendar_event_hash": "b273bf4b0cc29287f6a089ac46526391d69c031047186164b6d1b3b792018224", "seminar_id": 582, "time_of_addition": "Sat, Sep 05, 2020 01:40"}, "583": {"seminar_date": "Thu, Sep 24, 2020", "seminar_time": "16:00", "timezone": "Europe/London", "posted": "Yes", "seminar_link": "https://ucl.zoom.us/webinar/register/2115991747712/WN_NvP9icNYT2O0Kxfu-v7QlQ", "password": "", "video_on_demand": "", "speaker_title": "Dr", "seminar_speaker": "Willias Masocha", "speaker_affil": "Department of Pharmacology and Therapeutics, Faculty of Pharmacy, Kuwait University, Kuwait", "speaker_twitter": "@SONAorg", "speaker_website": "https://scholar.google.com/citations?user=0os5kRgAAAAJ&hl=en", "topic_tags": "pain, endocannabinoid", "seminar_title": "Targeting the Endocannabinoid System for Management of Chemotherapy, HIV and Antiretroviral-Induced Neuropathic Pain", "seminar_abstract": "Chemotherapeutic drugs (used for treating cancer), HIV infection and antiretroviral therapy (ART) can independently cause difficult-to-manage painful neuropathy. Paclitaxel, a chemotherapeutic drug, for example is associated with high incidence of peripheral neuropathy, around 71% of the patients of which 27% of these develop neuropathic pain. Use of cannabis or phytocannabinoids has been reported to improve pain measures in patients with neuropathic pain, including painful HIV-associated sensory neuropathy and cancer pain. Phytocannabinoids and endocannabinoids, such as anandamide and 2-arachidonoylglycerol (2-AG), produce their effects via cannabinoid (CB) receptors, which are present both in the periphery and central nervous system. Endocannabinoids are synthesized in an \u201con demand\u201d fashion and are degraded by various enzymes such as fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MGL). Various studies, including those from our group, suggest that there are changes in gene and protein expression of endocannabinoid molecules during chemotherapy-induced neuropathic pain (CINP), HIV and antiretroviral-induced neuropathic pain. Analysis of endocannabinoid molecule expression in the brain, spinal cord and paw skin using LC-MS/MS show that there is a specific deficiency of the endocannabinoids 2-AG and/or anandamide in the periphery during CINP. Various drugs including endocannabinoids, cannabidiol, inhibitors of FAAH and MGL, CB receptor agonists, desipramine and coadministered indomethacin plus minocycline have been found to either prevent the development and/or attenuate established CINP, HIV and antiretroviral-induced neuropathic pain in a CB receptor-dependent manner. The results available suggest that targeting the endocannabinoid system for prevention and treatment of CINP, HIV-associated neuropathic pain and antiretroviral-induced neuropathic pain is a plausible therapeutic option.", "hosted_by": "SONA", "domain": ["Neuroscience"], "calendar_event_hash": "6e7174f21277c5eafe35889fa7f7b91f967b8b47c00b0f5f7f4c4143926f9175", "seminar_id": 583, "time_of_addition": "Sat, Sep 05, 2020 01:50"}, "584": {"seminar_date": "Thu, Oct 1, 2020", "seminar_time": "16:00", "timezone": "Europe/London", "posted": "Yes", "seminar_link": "https://ucl.zoom.us/webinar/register/9715985274270/WN_tLKJDsJAR_qLlWHD2_xvuw", "password": "", "video_on_demand": "", "speaker_title": "Dr", "seminar_speaker": "Bess Frost", "speaker_affil": "Barshop Institute for Longevity and Aging Studies", "speaker_twitter": "@SONAorg", "speaker_website": "https://barshopinstitute.uthscsa.edu/team-member/frost-bess/", "topic_tags": "neurodegeneration, alzheimer's", "seminar_title": "Transposable element activation in Alzheimer's disease and related tauopathies", "seminar_abstract": "Transposable elements, known colloquially as \u2018jumping genes\u2019, constitute approximately 45% of the human genome. Cells utilize epigenetic defenses to limit transposable element jumping, including formation of silencing heterochromatin and generation of piwi-interacting RNAs (piRNAs), small RNAs that facilitate clearance of transposable element transcripts. We have utilized fruit flies, mice and postmortem human brain samples to identify transposable element dysregulation as a key mediator of neuronal death in tauopathies, a group of neurodegenerative disorders that are pathologically characterized by deposits of tau protein in the brain. Mechanistically, we find that heterochromatin decondensation and reduction of piwi and piRNAs drive transposable element dysregulation in tauopathy. We further report a significant increase in transcripts of the endogenous retrovirus class of transposable elements in human Alzheimer\u2019s disease and progressive supranuclear palsy, suggesting that transposable element dysregulation is conserved in human tauopathy. Taken together, our data identify heterochromatin decondensation, piwi and piRNA depletion and consequent transposable element dysregulation as a pharmacologically targetable, mechanistic driver of neurodegeneration in tauopathy.", "hosted_by": "SONA", "domain": ["Neuroscience"], "calendar_event_hash": "b55d4c9f7492a13f25f4bd6058e60a4486f8fdf03da14fa2d75656d7afc4ab46", "seminar_id": 584, "time_of_addition": "Sat, Sep 05, 2020 01:50"}, "645": {"seminar_date": "Thur, Oct 8,2020", "seminar_time": "16:00", "timezone": "Europe/London", "posted": "Yes", "seminar_link": "https://ucl.zoom.us/webinar/register/6215997799402/WN_VClcCYyvS6y8D7GTcfWmqA", "password": "", "video_on_demand": "", "speaker_title": "Dr", "seminar_speaker": "Beth Stevens", "speaker_affil": "Harvard Medical School", "speaker_twitter": "@SONAorg", "speaker_website": "https://www.stevenslab.org/people", "topic_tags": "neurodegeneration, dementia, microglia", "seminar_title": "Microglia function and dysfunction in Alzheimer\u2019s disease", "seminar_abstract": "Emerging genetic studies of late-onset Alzheimer\u2019s Disease implicate the brain\u2019s resident macrophages in the pathogenesis of AD. More than half the risk genes associated with late-onset AD are selectively expressed in microglia and peripheral myeloid cells; yet we know little about the underlying biology or how myeloid cells contribute to AD pathogenesis. Using single-cell RNA sequencing and spatial transcriptomics we identified molecular signatures that can be used to localize and monitor distinct microglia functional states in the human and mouse brain. Our results show that microglia assume diverse functional states in development, aging and injury, including populations corresponding to known microglial functions including proliferation, migration, inflammation, and synaptic phagocytosis. We identified several innate immune pathways by which microglia recognize and prune synapses during development and in models of Alzheimer\u2019s disease, including the classical complement cascade. Illuminating the mechanisms by which developing synaptic circuits are sculpted is providing important insight on understanding how to protect synapses in Alzheimer\u2019s and other neurodegenerative diseases of synaptic dysfunction.", "hosted_by": "SONA", "domain": ["Neuroscience"], "calendar_event_hash": "c21b9c4091132e4a287928f96629b1cc68a1bc3f224c9fca99796c975db29f31", "seminar_id": 645, "time_of_addition": "Sun, Sep 13, 2020 00:30"}, "646": {"seminar_date": "Thu, Oct 15, 2020", "seminar_time": "16:00", "timezone": "Europe/London", "posted": "Yes", "seminar_link": "https://ucl.zoom.us/webinar/register/1915992622145/WN_aHoK1tB_R4iIjna-lJZe_Q", "password": "", "video_on_demand": "", "speaker_title": "Dr", "seminar_speaker": "Arif Hamid", "speaker_affil": "Howard Hughes Medical Institute", "speaker_twitter": "@SONAorg", "speaker_website": "http://arifahamid.com/index.html", "topic_tags": "decision making", "seminar_title": "The role of spatiotemporal waves in coordinating regional dopamine decision signals", "seminar_abstract": "The neurotransmitter dopamine is essential for normal reward learning and motivational arousal processes. Indeed these core functions are implicated in the major neurological and psychiatric dopamine disorders such as schizophrenia, substance abuse disorders/addiction and Parkinson's disease. Over the years, we have made significant strides in understanding the dopamine system across multiple levels of description, and I will focus on our recent advances in the computational description, and brain circuit mechanisms that facilitate the dual role of dopamine in learning and performance. I will specifically describe our recent work with imaging the activity of dopamine axons and measurements of dopamine release in mice performing various behavioural tasks. We discovered wave-like spatiotemporal activity of dopamine in the striatal region, and I will argue that this pattern of activation supports a critical computational operation; spatiotemporal credit assignment to regional striatal subexperts. Our findings provide a mechanistic description for vectorizing reward prediction error signals relayed by dopamine.", "hosted_by": "SONA", "domain": ["Neuroscience"], "calendar_event_hash": "77f49969c39cd1e1f7e8a5d4f1da1be1a342cbb438f7abd5d6e13f6d8b82d2c8", "seminar_id": 646, "time_of_addition": "Sun, Sep 13, 2020 00:30"}, "647": {"seminar_date": "Thu, Oct 22, 2020", "seminar_time": "16:00", "timezone": "Europe/London", "posted": "Yes", "seminar_link": "https://ucl.zoom.us/webinar/register/2815992600827/WN_Vhk7DXzLQuejT6_dt9IgVw", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Nouria Lakhdar-Ghazal", "speaker_affil": "Mohammed V University, Morocco", "speaker_twitter": "@SONAorg", "speaker_website": "https://www.researchgate.net/profile/Nouria_Lakhdar_Ghazal", "topic_tags": "Parkinson's, neurotoxicity", "seminar_title": "Neurotoxicity is a major health problem in Africa: focus on Parkinson's / Parkinsonism", "seminar_abstract": "Parkinson's disease (PD) is the second most present neurodegenerative disease in the world after Alzheimer's. It is due to the progressive and irreversible loss of dopaminergic neurons of the substantia nigra Pars Compacta. Alpha synuclein deposits and the appearance of Lewi bodies are systematically associated with it. PD is characterized by four cardinal motor symptoms: bradykinesia / akinesia, rigidity, postural instability and tremors at rest. These symptoms appear when 80% of the dopaminergic endings disappear in the striatum. According to Braak's theory, non-motor symptoms appear much earlier and this is particularly the case with anxiety, depression, anhedonia, and sleep disturbances. In 90 to 95% of cases, the causes of the appearance of the disease remain unknown, but polluting toxic molecules are incriminated more and more. In Africa, neurodegenerative diseases of the Parkinson's type are increasingly present and a parallel seems to exist between the increase in cases and the presence of toxic and polluting products such as metals. My Web conference will focus on this aspect, i.e. present experimental arguments which reinforce the hypothesis of the incrimination of these pollutants in the incidence of Parkinson's disease and / or Parkinsonism. Among the lines of research that we have developed in my laboratory in Rabat, Morocco, I have chosen this one knowing that many of our PhD students and IBRO Alumni are working or trying to develop scientific research on neurotoxicity in correlation with pathologies of the brain.", "hosted_by": "SONA", "domain": ["Neuroscience"], "calendar_event_hash": "5f4de64f469df2506ff566df2583cf6924b1bfb8c34e9f5fc701a195ff009410", "seminar_id": 647, "time_of_addition": "Sun, Sep 13, 2020 00:30"}, "870": {"seminar_date": "Thu, May 28, 2020", "seminar_time": "16:00", "timezone": "Europe/Brussels", "posted": "yes", "seminar_link": "mailto: events.cbd@kuleuven.vib.be", "password": "", "video_on_demand": "", "speaker_title": "", "seminar_speaker": "Henne Holstege", "speaker_affil": "Amsterdam UMC", "speaker_twitter": "", "speaker_website": "https://research.vumc.nl/en/persons/henne-holstege", "topic_tags": "genetics, neurodegeneration", "seminar_title": "", "seminar_abstract": "", "hosted_by": "VIB Brain & Disease", "domain": ["Neuroscience"], "calendar_event_hash": "e1b4380dd73e5134ffbfb8f6f67e7d8f3cc154b281c2b5567d71f462905e034c", "seminar_id": 870, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "871": {"seminar_date": "Thu, Jun 11, 2020", "seminar_time": "16:00", "timezone": "Europe/Brussels", "posted": "yes", "seminar_link": "mailto: events.cbd@kuleuven.vib.be", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Beatriz Rico", "speaker_affil": "King's College London", "speaker_twitter": "", "speaker_website": "http://devneuro.org.uk/rico/default.aspx", "topic_tags": "development", "seminar_title": "Molecular Programs orchestrating the wiring of inhibitory circuitries", "seminar_abstract": "", "hosted_by": "VIB Brain & Disease", "domain": ["Neuroscience"], "calendar_event_hash": "dfc3c0dec3f18a7931f810589dbf7c22e0e64348dba36094728247bbb75f3a48", "seminar_id": 871, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "577": {"seminar_date": "Tue, Sep 8, 2020", "seminar_time": "16:00", "timezone": "Europe/Brussels", "posted": "yes", "seminar_link": "mailto: events.cbd@kuleuven.vib.be", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Barak A. Cohen", "speaker_affil": "Washington University, St. Louis", "speaker_twitter": "", "speaker_website": "http://genetics.wustl.edu/bclab/", "topic_tags": "genetics", "seminar_title": "Integration of Local and Regional cis-Regulatory Information in the Genome", "seminar_abstract": "", "hosted_by": "VIB Brain & Disease", "domain": ["Neuroscience"], "calendar_event_hash": "e3df6efbe9b9648f02babdcd9ab8347c7ce8f67f857b784b0ddb45646419d11c", "seminar_id": 577, "time_of_addition": "Fri, Sep 04, 2020 12:10"}, "934": {"seminar_date": "Thu, Oct 1, 2020", "seminar_time": "16:00", "timezone": "Europe/Brussels", "posted": "yes", "seminar_link": "https://teams.microsoft.com/l/meetup-join/19%3ameeting_MGUwM2M5NjctM2ZjMS00OTZiLThlMzgtNjdmOThmZDZhMDJm%40thread.v2/0?context=%7b%22Tid%22%3a%222d714a65-b97f-41a9-8ff1-ec2cdf7df5cd%22%2c%22Oid%22%3a%22ec6cbc10-68c3-47fe-a042-91ee01590c06%22%2c%22IsBroadcastMeeting%22%3atrue%7d", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Rosa Rademakers", "speaker_affil": "VIB-UAntwerp Center for Molecular Neurology", "speaker_twitter": "@CMN_VIB", "speaker_website": "https://uantwerpen.vib.be/group/RosaRademakers", "topic_tags": "genetics, dementia, disease", "seminar_title": "A decade of TMEM106B research", "seminar_abstract": "", "hosted_by": "VIB Brain & Disease", "domain": ["Neuroscience"], "calendar_event_hash": "b2c82bb295acbe3b93d3e1e0abe02590feea2377cd6c7e4811688a4b23193c04", "seminar_id": 934, "time_of_addition": "Mon, Sep 28, 2020 12:15"}, "838": {"seminar_date": "Fri, Jun 26, 2020", "seminar_time": "15:30", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/jimhaxby", "password": "", "video_on_demand": "https://www.crowdcast.io/e/jimhaxby", "speaker_title": "Prof.", "seminar_speaker": "James Haxby", "speaker_affil": "Dartmouth College", "speaker_twitter": "@haxbylab", "speaker_website": "https://faculty-directory.dartmouth.edu/james-v-haxby", "topic_tags": "cognitive, fMRI, computational", "seminar_title": "Hyperalignment: Modeling shared information encoded in idiosyncratic cortical topographies", "seminar_abstract": "Information that is shared across brains is encoded in idiosyncratic fine-scale functional topographies. Hyperalignment jointly models shared information and idiosyncratic topographies. Pattern vectors for neural responses and connectivities are projected into a common, high-dimensional information space, rather than being aligned in a canonical anatomical space. Hyperalignment calculates individual transformation matrices that preserve the geometry of pairwise dissimilarities between pattern vectors. Individual cortical topographies are modeled as mixtures of overlapping, individual-specific topographic basis functions, rather than as contiguous functional areas. The fundamental property of brain function that is preserved across brains is information content, rather than the functional properties of local features that support that content.", "hosted_by": "Oxford WINeuro", "domain": ["Neuroscience"], "calendar_event_hash": "fe60814ea981a45d5a14ecb0a31e01d2f811afd52fd68fb6781cbedae938feae", "seminar_id": 838, "time_of_addition": "Mon, Sep 28, 2020 11:06"}, "839": {"seminar_date": "Wed, Jul 1, 2020", "seminar_time": "14:30", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/chris-baldassano", "password": "", "video_on_demand": "https://www.crowdcast.io/e/chris-baldassano", "speaker_title": "Dr", "seminar_speaker": "Chris Baldassano", "speaker_affil": "Columbia University", "speaker_twitter": "@ChrisBaldassano", "speaker_website": "http://www.chrisbaldassano.com/", "topic_tags": "cognition, fMRI, memory", "seminar_title": "Schemas: events, spaces, semantics, and development", "seminar_abstract": "Understanding and remembering realistic experiences in our everyday lives requires activating many kinds of structured knowledge about the world, including spatial maps, temporal event scripts, and semantic relationships. My recent projects have explored the ways in which we build up this schematic knowledge (during a single experiment and across developmental timescales) and can strategically deploy them to construct event representations that we can store in memory or use to make predictions. I will describe my lab's ongoing work developing new experimental and analysis techniques for conducting functional MRI experiments using narratives, movies, poetry, virtual reality, and \"memory experts\" to study complex naturalistic schemas.", "hosted_by": "Oxford WINeuro", "domain": ["Neuroscience"], "calendar_event_hash": "c464090ad55e66fdc2b06ee21ab0db5f0c90e95e64ad73f608c7c589880f2490", "seminar_id": 839, "time_of_addition": "Mon, Sep 28, 2020 11:06"}, "840": {"seminar_date": "Wed, Jul 22, 2020", "seminar_time": "16:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/eric-knudsen", "password": "", "video_on_demand": "https://www.crowdcast.io/e/eric-knudsen", "speaker_title": "Dr", "seminar_speaker": "Eric Knudsen", "speaker_affil": "UC Berkeley (Joni Wallis's lab)", "speaker_twitter": "", "speaker_website": "", "topic_tags": "decision making, OFC, hippocampus", "seminar_title": "Learning in abstract value spaces", "seminar_abstract": "Learning the consequences our choices have as we interact with our world is critical for flexible behavior. Relational knowledge of one\u2019s environment gives structure to otherwise-individual one-to-one stimulus-outcome mappings, providing a substrate to globally update behavioral contingencies in the face of changes in the landscape of reward. In the brain, this relational knowledge is thought to be encoded in the hippocampus (HPC) in the form of a cognitive map, while prefrontal regions, such as orbitofrontal cortex (OFC), are thought to instantiate subjective estimates of location on the map, though direct neurophysiological evidence is lacking. In this talk, I will present recent work demonstrating the causal relationship between HPC and OFC as nonhuman primates perform a reward learning task requiring them to learn and maintain knowledge of changing stimulus-outcome associations. I will then provide direct evidence that single primate hippocampal neurons represent an abstract map of the value space defined by the task. Finally, I use behavioral modeling to highlight one possible strategy by which knowledge of value space is exploited by animals to detect changes in choice-outcome mappings and proactively update their behavior in response.", "hosted_by": "Oxford WINeuro", "domain": ["Neuroscience"], "calendar_event_hash": "8bab4d5aa27d774729d1757825b48c91ce07b2f9394b30dad3ea87d3a52fa89c", "seminar_id": 840, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "348": {"seminar_date": "Fri, Jul 31, 2020", "seminar_time": "16:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/alice-berners-lee", "password": "", "video_on_demand": "https://www.crowdcast.io/e/alice-berners-lee", "speaker_title": "", "seminar_speaker": "Alice Berners-Lee", "speaker_affil": "Johns Hopkins / UC Berkeley (David Foster's lab)", "speaker_twitter": "@AliceBLee", "speaker_website": "", "topic_tags": "hippocampus, replay, spatial cognition", "seminar_title": "Hippocampal replays appear after a single experience and slow down with subsequent experience as greater detail is incorporated", "seminar_abstract": "The hippocampus is implicated in memory formation, and neurons in the hippocampus take part in replay sequences, time-compressed reactivations of trajectories through space the animal has previously explored. These replay sequences have been proposed to be a form of memory for previously experienced places. I will present work exploring how these replays appear and change with experience. By recording from large ensembles of hippocampal neurons as rats explored novel and familiar linear tracks in various experiments, we found that hippocampal replays appear after a single experience and slow down with subsequent experience as greater detail is incorporated. We also investigated hover-and-jump dynamics within replays that are associated with the slow gamma (25-50Hz) oscillation in the LFP and found that replays slow down by adding more hover locations, corresponding to depiction of the behavioral trajectory with increased resolution. Thus, replays can reflect single experiences, and be rapidly modified by subsequent experience to incorporate more detail, consistent with their proposed role as a basic mechanism of hippocampally dependent memory.", "hosted_by": "Oxford WINeuro", "domain": ["Neuroscience"], "calendar_event_hash": "5a42e5de608bb84ab1aa0cf5f2166a8a8df2f8956de1e2558a0d224e48735055", "seminar_id": 348, "time_of_addition": "Wed, Jul 08, 2020 17:30"}, "841": {"seminar_date": "Wed, Aug 5, 2020", "seminar_time": "11:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/yaara-yeshurun", "password": "", "video_on_demand": "https://www.crowdcast.io/e/yaara-yeshurun", "speaker_title": "Dr", "seminar_speaker": "Yaara Yeshurun", "speaker_affil": "Tel Aviv University", "speaker_twitter": "", "speaker_website": "https://people.socsci.tau.ac.il/mu/yaarayeshurun/", "topic_tags": "social cognition, cognition, fMRI, fNIRS", "seminar_title": "It\u2019s not what you look at that matters, it\u2019s what you see", "seminar_abstract": "People frequently interpret the same information differently, based on their prior beliefs and views. This may occur in everyday settings, as when two friends are watching the same movie, but also in more consequential circumstances, such as when people interpret the same news differently based on their political views. The role of subjective knowledge in altering how the brain processes narratives has been explored mainly in controlled settings. I will present two projects that examines neural mechanisms underlying narrative interpretation \u201cin the wild\u201d -- how responses differ between two groups of people who interpret the same narrative in two coherent, but opposing ways. In the first project we\nmanipulated participant\u2019s prior knowledge to make them interpret the narrative differently, and found that responses in high-order areas, including the default mode network, language areas and subsets of the mirror neuron system, tend to be similar among people who share the same interpretation, but different from people with an opposing interpretation. In contrast to the active manipulation of participants\u2019 interpretation in the first study, in the second (ongoing) project we examine these processes in a more ecological setting. Taking advantage of people\u2019s natural tendencies to interpret the world through their own (political) filters, we examine these mechanisms while measuring their brain response to political movie clips. These studies are intended to deepen our understanding of the differences in subjective construal processes, by mapping their underlying brain mechanisms.", "hosted_by": "Oxford WINeuro", "domain": ["Neuroscience"], "calendar_event_hash": "2e5477f203b2d11c4c30bdf8527d2a203124633476d63a7c333d75e02d012bdc", "seminar_id": 841, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "338": {"seminar_date": "Wed, Aug 12, 2020", "seminar_time": "15:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/dwight-kravitz", "password": "", "video_on_demand": "https://www.crowdcast.io/e/dwight-kravitz", "speaker_title": "Prog", "seminar_speaker": "Dwight Kravitz", "speaker_affil": "George Washington University", "speaker_twitter": "", "speaker_website": "https://cogneurolab.columbian.gwu.edu/", "topic_tags": "fMRI, cognition, vision, perception", "seminar_title": "The consequences and constraints of functional organization on behavior", "seminar_abstract": "In many ways, cognitive neuroscience is the attempt to use physiological observation to clarify the mechanisms that shape behavior. Over the past 25 years, fMRI has provided a system-wide and yet somewhat spatially precise view of the response in human cortex evoked by a wide variety of stimuli and task contexts. The current talk focuses on the other direction of inference; the implications of this observed functional organization for behavior. To begin, we must interrogate the methodological and empirical frameworks underlying our derivation of this organization, partially by exploring its relationship to and predictability from gross neuroanatomy. Next, across a series of studies, the implications of two properties of functional organization for behavior will be explored: 1) the co-localization of visual working memory and perceptual processing and 2) implicit learning in the context of distributed responses. In sum, these results highlight the limitations of our current approach and hint at a new general mechanism for explaining observed behavior in context with the neural substrate.", "hosted_by": "Oxford WINeuro", "domain": ["Neuroscience"], "calendar_event_hash": "123dae1720576de3577591d85ba52cb141f6d8d5e67325a9f51d7557ad737edf", "seminar_id": 338, "time_of_addition": "Tue, Jul 07, 2020 11:40"}, "316": {"seminar_date": "Fri, Aug 21, 2020", "seminar_time": "15:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/janice-chen", "password": "", "video_on_demand": "https://www.crowdcast.io/e/janice-chen", "speaker_title": "Dr", "seminar_speaker": "Janice Chen", "speaker_affil": "Johns Hopkins", "speaker_twitter": "@kanileke", "speaker_website": "http://jchenlab.johnshopkins.edu/", "topic_tags": "cognition, fMRI, memory", "seminar_title": "Brain dynamics underlying memory for continuous natural events", "seminar_abstract": "The world confronts our senses with a continuous stream of rapidly changing information. Yet, we experience life as a series of episodes or events, and in memory these pieces seem to become even further organized. How do we recall and give structure to this complex information? Recent studies have begun to examine these questions using naturalistic stimuli and behavior: subjects view audiovisual movies and then freely recount aloud their memories of the events. We find brain activity patterns that are unique to individual episodes, and which reappear during verbal recollection; robust generalization of these patterns across people; and memory effects driven by the structure of links between events in a narrative. These findings construct a picture of how we comprehend and recall real-world events that unfold continuously across time.", "hosted_by": "Oxford WINeuro", "domain": ["Neuroscience"], "calendar_event_hash": "db40b90679119a32eeb874359c8449372b05bdca6f2768f1537f351f66b7dbab", "seminar_id": 316, "time_of_addition": "Fri, Jul 03, 2020 14:00"}, "842": {"seminar_date": "Wed, Aug 26, 2020", "seminar_time": "16:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/anne-collins", "password": "", "video_on_demand": "https://www.crowdcast.io/e/anne-collins", "speaker_title": "Dr", "seminar_speaker": "Anne Collins", "speaker_affil": "UC Berkeley", "speaker_twitter": "@ccnlab", "speaker_website": "https://ccn.berkeley.edu/", "topic_tags": "RL, theory, fMRI, cognition", "seminar_title": "Working memory transforms goals into rewards", "seminar_abstract": "Humans continuously need to learn to make good choices \u2013 be it using a new video-conferencing set up, figuring out what questions to ask to successfully secure a reliable babysitter, or just selecting which location in a house is least likely to be interrupted by toddlers during work calls. However, the goals we seek to attain \u2013 such as using zoom successfully \u2013 are often vaguely defined and previously unexperienced, and in that sense cannot be known by us as being rewarding. We hypothesized that learning to make good choices in such situations nevertheless leverages reinforcement learning processes, and that executive functions in general, and working memory in particular, play a crucial role in defining the reward function for arbitrary outcomes in such a way that they become reinforcing. I will show results from a novel behavioral protocol, as well as preliminary computational and imaging evidence supporting our hypothesis.", "hosted_by": "Oxford WINeuro", "domain": ["Neuroscience"], "calendar_event_hash": "a3c42bd8cbd0406f75bf3ebc685fe2a0cd3212fdd38b5ff4ae43159bb4a7e159", "seminar_id": 842, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "843": {"seminar_date": "Wed, Sep 2, 2020", "seminar_time": "15:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/rita-goldstein", "password": "", "video_on_demand": "https://www.crowdcast.io/e/rita-goldstein", "speaker_title": "Prof", "seminar_speaker": "Rita Goldstein", "speaker_affil": "Mount Sinai", "speaker_twitter": "", "speaker_website": "", "topic_tags": "psychiatry, cognitive, fMRI", "seminar_title": "Neuroimaging in human drug addiction: an eye towards intervention development / Rita Z. Goldstein", "seminar_abstract": "Drug addiction is a chronically relapsing disorder characterized by compulsive drug use despite catastrophic personal consequences (e.g., loss of family, job) and even when the substance is no longer perceived as pleasurable. In this talk, I will present results of human neuroimaging studies, utilizing a multimodal approach (neuropsychology, functional magnetic resonance imaging, event-related potentials recordings), to explore the neurobiology underlying the core psychological impairments in drug addiction (impulsivity, drive/motivation, insight/awareness) as associated with its clinical symptomatology (intoxication, craving, bingeing, withdrawal). The focus of this talk is on understanding the role of the dopaminergic mesocorticolimbic circuit, and especially the prefrontal cortex, in higher-order executive dysfunction (e.g., disadvantageous decision-making such as trading a car for a couple of cocaine hits) in drug addicted individuals. The theoretical model that guides the presented research is called iRISA (Impaired Response Inhibition and Salience Attribution), postulating that abnormalities in the orbitofrontal cortex and anterior cingulate cortex, as related to dopaminergic dysfunction, contribute to the core clinical symptoms in drug addiction. Specifically, our multi-modality program of research is guided by the underlying working hypothesis that drug addicted individuals disproportionately attribute reward value to their drug of choice at the expense of other potentially but no-longer-rewarding stimuli, with a concomitant decrease in the ability to inhibit maladaptive drug use. In this talk I will also explore whether treatment (as usual) and 6-month abstinence enhance recovery in these brain-behavior compromises in treatment seeking cocaine addicted individuals. Promising neuroimaging studies, which combine pharmacological (i.e., oral methylphenidate, or RitalinTM) and salient cognitive tasks or functional connectivity during resting-state, will be discussed as examples for using neuroimaging for empirically guiding the development of effective neurorehabilitation strategies (encompassing cognitive reappraisal and transcranial direct current stimulation) in drug addiction.", "hosted_by": "Oxford WINeuro", "domain": ["Neuroscience"], "calendar_event_hash": "c8f867cd4eb9a6f2cf8da2b889b9c2e0a65370b43f50961b2f99a2461c85a061", "seminar_id": 843, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "290": {"seminar_date": "Wed, Aug 5, 2020", "seminar_time": "17:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/peyman-golshanis-world", "password": "", "video_on_demand": "https://www.youtube.com/watch?v=tVQuCVeTWq8", "speaker_title": "Prof", "seminar_speaker": "Peyman Golshani", "speaker_affil": "UCLA", "speaker_twitter": "@pgolshani", "speaker_website": "https://golshanilab.neurology.ucla.edu/", "topic_tags": "epilepsy, interneurons", "seminar_title": "Interneuron desynchronization and breakdown of long-term place cell stability in temporal lobe epilepsy", "seminar_abstract": "Temporal lobe epilepsy is associated with memory deficits but the circuit mechanisms underlying these cognitive disabilities are not understood. We used electrophysiological recordings, open-source wire-free miniaturized microscopy and computational modeling to probe these deficits in a model of temporal lobe epilepsy. We find desynchronization of dentate gyrus interneurons with CA1 interneurons during theta oscillations and a loss of precision and stability of place fields. We also find that emergence of place cell dysfunction is delayed, providing a potential temporal window for treatments. Computation modeling shows that desynchronization rather than interneuron cell loss can drive place cell dysfunction. Future studies will uncover cell types driving these changes and transcriptional changes that may be driving dysfunction.", "hosted_by": "Experimental Epilepsy", "domain": ["Neuroscience"], "calendar_event_hash": "30bb2547e6cd7f4c70d1d24a2cf1c0af6c5ec01687b40e60849710b9b155469f", "seminar_id": 290, "time_of_addition": "Fri, Jul 03, 2020 14:00"}, "291": {"seminar_date": "Wed, Aug 19, 2020", "seminar_time": "17:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/alfredo-gonzalez-sulsers", "password": "", "video_on_demand": "https://youtu.be/IH2AkhWFip0", "speaker_title": "Dr", "seminar_speaker": "Alfredo Gonzalez-Sulser", "speaker_affil": "University of Edinburgh", "speaker_twitter": "@SulserGonzalez", "speaker_website": "https://www.ed.ac.uk/discovery-brain-sciences/our-staff/research-groups/alfredo-gonzalez-sulser", "topic_tags": "epilepsy, interneurons", "seminar_title": "Medial Septal GABAergic Neurons Reduce Seizure Duration Upon Wireless Optogenetic Closed-Loop Stimulation", "seminar_abstract": "Seizures can emerge from multiple or large foci in temporal lobe epilepsy (TLE), complicating focally targeted strategies such as surgical resection or the modulation of the activity of specific hippocampal neuronal populations through genetic or optogenetic techniques. Here, we evaluate a strategy in which optogenetic activation of medial septal GABAergic neurons (MSGNs), which provide extensive projections throughout the hippocampus, is used to control seizures. We found that MSGNs were structurally and functionally resilient in the chronic intrahippocampal kainate mouse model of TLE, which as is often the case in human TLE patients, presents with hippocampal sclerosis. Optogenetic stimulation of MSGNs modulated oscillations across the rostral to caudal extent of the hippocampus in epileptic conditions. Chronic wireless optogenetic stimulation of MSGNs, upon electrographic detection of spontaneous hippocampal seizures, resulted in reduced seizure durations. We propose MSGNs as a novel target for optogenetic control of seizures in TLE.", "hosted_by": "Experimental Epilepsy", "domain": ["Neuroscience"], "calendar_event_hash": "733fd1a29f3b61fdf4361dce38a2ac73a4f9ee9a9398aafa60c2aae4649c652a", "seminar_id": 291, "time_of_addition": "Fri, Jul 03, 2020 14:00"}, "292": {"seminar_date": "Wed, Sep 2, 2020", "seminar_time": "17:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/andrew-trevelyans-world", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Andrew Trevelyan", "speaker_affil": "Newcastle University", "speaker_twitter": "", "speaker_website": "https://www.ncl.ac.uk/medical-sciences/people/profile/andrewtrevelyan.html", "topic_tags": "epilepsy, interneurons, network, seizures", "seminar_title": "Positive and negative feedback in seizure initiation", "seminar_abstract": "Seizure onset is a critically important brain state transition that has proved very difficult to predict accurately from recordings of brain activity. I will present new data acquired using a range of optogenetic and imaging tools to characterize exactly how cortical networks change in the build-up to a seizure. I will show how intermittent optogenetic stimulation (\"active probing\") reveals a latent change in dendritic excitability that is tightly correlated to the onset of seizure activity. This data relates back to old work from the 1980s suggesting a critical role in epileptic pathophysiology for dendritic plateau potentials. Our data show how the precipitous nature of the transition can be understood in terms of multiple, synergistic positive feedback mechanisms.", "hosted_by": "Experimental Epilepsy", "domain": ["Neuroscience"], "calendar_event_hash": "d3d915a0c65e2eaee774630d5fd4e9f15f013b92d11b8ab09ca805183854b289", "seminar_id": 292, "time_of_addition": "Fri, Jul 03, 2020 14:00"}, "293": {"seminar_date": "Wed, Sep 16, 2020", "seminar_time": "17:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/christophe-bernards", "password": "", "video_on_demand": "https://youtu.be/24kNLJDPNRo", "speaker_title": "Prof", "seminar_speaker": "Christophe Bernard", "speaker_affil": "Aix-Marseille Universit\u00e9", "speaker_twitter": "@eNeuroEiC", "speaker_website": "https://ins-amu.fr/physionet", "topic_tags": "epilepsy, circadian rhythms, sleep", "seminar_title": "Circadian/Multidien Molecular Oscillations and Rhythmicity of Epilepsy", "seminar_abstract": "The occurrence of seizures at specific times of the day has been consistently observed for centuries in individuals with epilepsy. Electrophysiological recordings provide evidence that seizures have a higher probability of occurring at a given time during the night and day cycle in individuals with epilepsy \u2013 the seizure rush hour. Which mechanisms underly such circadian rhythmicity of seizures? Why don\u2019t they occur every day at the same time? Which mechanisms may underly their occurrence outside the rush hour? I shall present a hypothesis: MORE - Molecular Oscillations and Rhythmicity of Epilepsy, a conceptual framework to study and understand the mechanisms underlying the circadian rhythmicity of seizures and their probabilistic nature. The core of the hypothesis is the existence of circa 24h oscillations of gene and protein expression throughout the body in different cells and organs. The orchestrated molecular oscillations control the rhythmicity of numerous body events, such as feeding and sleep. The concept developed here is that molecular oscillations may favor seizure genesis at preferred times, generating the condition for a seizure rush hour. However, the condition is not sufficient, as other factors are necessary for a seizure to occur. Studying these molecular oscillations may help us understand seizure genesis mechanisms and find new therapeutic targets and predictive biomarkers. The MORE hypothesis can be generalized to comorbidities and the slower multidien (week/month period) rhythmicity of seizures.", "hosted_by": "Experimental Epilepsy", "domain": ["Neuroscience"], "calendar_event_hash": "8ec54eeb91c4054022bcfed7dda494c25fe0fb29960d521e9ee69ce63d5df83a", "seminar_id": 293, "time_of_addition": "Fri, Jul 03, 2020 14:00"}, "294": {"seminar_date": "Wed, Oct 7, 2020", "seminar_time": "17:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/jeff-noebelss-world-wide", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Jeff Noebels", "speaker_affil": "Baylor College of Medicine", "speaker_twitter": "", "speaker_website": "https://www.bcm.edu/people-search/jeffrey-noebels-27644", "topic_tags": "epilepsy, epileptogenesis, glioma", "seminar_title": "Sparks, flames, and inferno: epileptogenesis in the glioblastoma microenvironment", "seminar_abstract": "Glioblastoma cells trigger pharmacoresistant seizures that may promote tumor growth and diminish the quality of remaining life. To define the relationship between growth of glial tumors and their neuronal microenvironment, and to identify genomic biomarkers and mechanisms that may point to better prognosis and treatment of  drug resistant epilepsy in brain cancer, we are analyzing a new generation of genetically defined CRISPR/in utero electroporation inborn glioblastoma (GBM) tumor models engineered in mice. The molecular pathophysiology of glioblastoma cells and surrounding neurons and untransformed astrocytes are compared at serial stages of tumor development. Initial studies reveal that epileptiform EEG spiking is a very early and reliable preclinical signature of GBM expansion in these mice, followed by rapidly progressive seizures and death within weeks. FACS-sorted transcriptomic analysis of cortical astrocytes reveals the expansion of a subgroup enriched in pro-synaptogenic genes that may drive hyperexcitability, a novel mechanism of epileptogenesis. Using a prototypical GBM IUE model, we systematically define and correlate the earliest appearance of cortical hyperexcitability with progressive cortical tumor cell invasion, including spontaneous episodes of spreading cortical depolarization, innate inflammation, and xCT upregulation in the peritumoral microenvironment. Blocking this glutamate exporter reduces seizure load. We show that the host genome contributes to seizure risk by generating tumors in a monogenic deletion strain (MapT/tau -/-) that raises cortical seizure threshold. We also show that the tumor variant profile determines epilepsy risk. Our genetic dissection approach sets the stage to broadly explore the developmental biology of personalized tumor/host interactions in mice engineered with novel human tumor mutations in specified glial cell lineages.", "hosted_by": "Experimental Epilepsy", "domain": ["Neuroscience"], "calendar_event_hash": "2bf0735d74fc55694f1dcc8a3aa7c18068353e305906a84862e4bc15f382ae4e", "seminar_id": 294, "time_of_addition": "Fri, Jul 03, 2020 14:00"}, "295": {"seminar_date": "Wed, Oct 21, 2020", "seminar_time": "17:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Matthew Weston", "speaker_affil": "University of Vermont", "speaker_twitter": "", "speaker_website": "http://www.med.uvm.edu/ecdgroup/groupmembers", "topic_tags": "epilepsy", "seminar_title": "TBD", "seminar_abstract": "", "hosted_by": "Experimental Epilepsy", "domain": ["Neuroscience"], "calendar_event_hash": "a88982e346e6ee25c25e4e81c83ced970cd660b320af6bed2ef539e87abcd328", "seminar_id": 295, "time_of_addition": "Fri, Jul 03, 2020 14:00"}, "296": {"seminar_date": "Wed, Nov 4, 2020", "seminar_time": "17:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Michele Simonato", "speaker_affil": "Universit\u00e0 Vita-Salute San Raffaele", "speaker_twitter": "", "speaker_website": "https://research.hsr.it/en/divisions/neuroscience/gene-therapy-of-neurodegenerative-diseases/michele-simonato.html", "topic_tags": "epilepsy, Gene Therapy, GDNF", "seminar_title": "Ex vivo gene therapy for epilepsy. Seizure-suppressant and neuroprotective effects of encapsulated GDNF-producing cells", "seminar_abstract": "", "hosted_by": "Experimental Epilepsy", "domain": ["Neuroscience"], "calendar_event_hash": "fd88adcccad95b9a13139c42bf84b5288bda8a5e14fca44cb550b0c2dd7e3512", "seminar_id": 296, "time_of_addition": "Fri, Jul 03, 2020 14:00"}, "297": {"seminar_date": "Wed, Nov 18, 2020", "seminar_time": "17:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Heinz Beck", "speaker_affil": "Institute for Experimental Epileptology and Cognition", "speaker_twitter": "", "speaker_website": "https://eecr-bonn.de/beck-group/", "topic_tags": "epilepsy, dendrites, cognitive comorbidities", "seminar_title": "Targeting aberrant dendritic integration to treat cognitive comorbidities of epilepsy", "seminar_abstract": "", "hosted_by": "Experimental Epilepsy", "domain": ["Neuroscience"], "calendar_event_hash": "13dd6a90ab6f7d54fd239c1a0a0c3a8fbe3299c2de85016f3a67dcfc2eea61a9", "seminar_id": 297, "time_of_addition": "Fri, Jul 03, 2020 14:00"}, "298": {"seminar_date": "Wed, Dec 2, 2020", "seminar_time": "17:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Kai Kaila", "speaker_affil": "University of Helsinki", "speaker_twitter": "", "speaker_website": "https://www.helsinki.fi/en/people/people-finder/kai-kaila-9034121", "topic_tags": "epilepsy, seizures, KCC2", "seminar_title": "The many faces of KCC2 in the generation and suppression of seizures", "seminar_abstract": "", "hosted_by": "Experimental Epilepsy", "domain": ["Neuroscience"], "calendar_event_hash": "ab04d15397ce7a234951f5195c81f35d0421a9b903ba4f9080c74d3521981d1f", "seminar_id": 298, "time_of_addition": "Fri, Jul 03, 2020 14:00"}, "299": {"seminar_date": "Wed, Dec 16, 2020", "seminar_time": "17:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Dirk Isbrandt", "speaker_affil": "Deutsches Zentrum fur Neurodegenerative Erkrankunngen", "speaker_twitter": "", "speaker_website": "https://www.dzne.de/en/research/research-areas/fundamental-research/research-groups/isbrandt/research-areasfocus/", "topic_tags": "epilepsy, development, channelopathies", "seminar_title": "Vulnerable periods of brain development in ion channelopathies", "seminar_abstract": "", "hosted_by": "Experimental Epilepsy", "domain": ["Neuroscience"], "calendar_event_hash": "ff48e1c9a431557e5e505291f9316122dd2854fcf5ca7f8ccab8758b02c468de", "seminar_id": 299, "time_of_addition": "Fri, Jul 03, 2020 14:00"}, "300": {"seminar_date": "Wed, Jan 6, 2021", "seminar_time": "17:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Karen Wilcox", "speaker_affil": "the University of Utah", "speaker_twitter": "@kswilcox", "speaker_website": "https://pharmacy.utah.edu/pharmtox/faculty/current-faculty/Wilcox-K.php", "topic_tags": "epilepsy, therapy, screening", "seminar_title": "New Directions of the Epilepsy Therapy Screening Program", "seminar_abstract": "", "hosted_by": "Experimental Epilepsy", "domain": ["Neuroscience"], "calendar_event_hash": "944e70e05e2c0bc0fea8bb2330c146e30397798cf104e3fe6f1bafe65e8b8d9c", "seminar_id": 300, "time_of_addition": "Fri, Jul 03, 2020 14:00"}, "301": {"seminar_date": "Wed, Jan 20, 2021", "seminar_time": "17:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Liset de la Prida", "speaker_affil": "INSTITUTO CAJAL", "speaker_twitter": "@LMPrida", "speaker_website": "http://hippo-circuitlab.es/", "topic_tags": "epilepsy", "seminar_title": "TBD", "seminar_abstract": "", "hosted_by": "Experimental Epilepsy", "domain": ["Neuroscience"], "calendar_event_hash": "210e5b6e1916fb720f07eb616e49d3d6aaaf8934d7c41b78182564a97a077418", "seminar_id": 301, "time_of_addition": "Fri, Jul 03, 2020 14:00"}, "302": {"seminar_date": "Wed, Feb 3, 2021", "seminar_time": "17:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Christoph Schwarzer", "speaker_affil": "Innsbruck University", "speaker_twitter": "", "speaker_website": "https://www.i-med.ac.at/pharmakologie/forschung/research_schwarzer.html", "topic_tags": "epilepsy, opioids receptor, drug therapy, hippocampus", "seminar_title": "The Kappa Opioid Receptor as Potential Drug Target in TLE", "seminar_abstract": "", "hosted_by": "Experimental Epilepsy", "domain": ["Neuroscience"], "calendar_event_hash": "c00077ec149ee2bd21995c700274af796c05d4b884e10453e0b528171991fc47", "seminar_id": 302, "time_of_addition": "Fri, Jul 03, 2020 14:00"}, "303": {"seminar_date": "Wed, Feb 17, 2021", "seminar_time": "17:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Chris Dulla", "speaker_affil": "Tufts University", "speaker_twitter": "@DullaChris", "speaker_website": "https://gsbs.tufts.edu/facultyResearch/faculty/dulla-chris", "topic_tags": "epilepsy", "seminar_title": "TBD", "seminar_abstract": "", "hosted_by": "Experimental Epilepsy", "domain": ["Neuroscience"], "calendar_event_hash": "73fe13bd4758f007ed169b9b68d5dcbc33e626d60e542a548c13b25362ceb4eb", "seminar_id": 303, "time_of_addition": "Fri, Jul 03, 2020 14:00"}, "304": {"seminar_date": "Wed, Mar 3, 2021", "seminar_time": "17:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Ethan Goldberg", "speaker_affil": "Children's Hospital of Philadelphia", "speaker_twitter": "@Go3than", "speaker_website": "https://goldbergneurolab.com/", "topic_tags": "epilepsy, Dravet, development", "seminar_title": "Cellular/circuit dysfunction across development in a model of Dravet syndrome", "seminar_abstract": "", "hosted_by": "Experimental Epilepsy", "domain": ["Neuroscience"], "calendar_event_hash": "769586e6f6f1c336a007c110d5df3ed724c95382d964a5a057364e9c49c762fd", "seminar_id": 304, "time_of_addition": "Fri, Jul 03, 2020 14:00"}, "305": {"seminar_date": "Wed, Mar 17, 2021", "seminar_time": "17:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Federico Zara", "speaker_affil": "Gaslini Hospital", "speaker_twitter": "", "speaker_website": "https://www.gaslini.org/staff/federico-zara/", "topic_tags": "epilepsy", "seminar_title": "TBD", "seminar_abstract": "", "hosted_by": "Experimental Epilepsy", "domain": ["Neuroscience"], "calendar_event_hash": "b606937b8d281a599af769ca1baf862b1f006c6c6b07ae92b1742b2a4db46614", "seminar_id": 305, "time_of_addition": "Fri, Jul 03, 2020 14:00"}, "306": {"seminar_date": "Wed, Apr 7, 2021", "seminar_time": "17:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Ivan Soltesz", "speaker_affil": "Stanford University", "speaker_twitter": "", "speaker_website": "http://med.stanford.edu/ivansolteszlab/front-page.html", "topic_tags": "epilepsy", "seminar_title": "Organization and control of hippocampal circuits in epilepsy", "seminar_abstract": "", "hosted_by": "Experimental Epilepsy", "domain": ["Neuroscience"], "calendar_event_hash": "29ae5ec6cc904cec3dcb40637923328ebf3f8a00ccc1a69f7e7adb89805c7a07", "seminar_id": 306, "time_of_addition": "Fri, Jul 03, 2020 14:00"}, "307": {"seminar_date": "Wed, Apr 21, 2021", "seminar_time": "17:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Massimo Mantegazza", "speaker_affil": "Institute of Molecular and Cellular Pharmacology", "speaker_twitter": "", "speaker_website": "https://www.ipmc.cnrs.fr/cgi-bin/site.cgi", "topic_tags": "epilepsy, Dravet, migraine, Sodium Channels", "seminar_title": "SCN1A/Nav1.1 sodium channel: loss and gain of function in epilepsy and migraine", "seminar_abstract": "", "hosted_by": "Experimental Epilepsy", "domain": ["Neuroscience"], "calendar_event_hash": "a6fa2ebf2eb9b9e9b2f730d73b963f2c3c4cc9d0d99683f19ae9f4b5511f24b6", "seminar_id": 307, "time_of_addition": "Fri, Jul 03, 2020 14:00"}, "308": {"seminar_date": "Wed, May 5, 2021", "seminar_time": "17:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Angelique Bordey", "speaker_affil": "Yale University", "speaker_twitter": "", "speaker_website": "https://medicine.yale.edu/lab/bordey/", "topic_tags": "epilepsy, Tuberous Sclerosis, mTOR, Focal Cortical Dysplasia", "seminar_title": "Understanding and treating epilepsy in tuberous sclerosis complex", "seminar_abstract": "", "hosted_by": "Experimental Epilepsy", "domain": ["Neuroscience"], "calendar_event_hash": "d3d808ea998b0d6a5068b8bf4b965f756ab9d4d88c1ad0be87dda117003b535e", "seminar_id": 308, "time_of_addition": "Fri, Jul 03, 2020 14:00"}, "309": {"seminar_date": "Wed, May 19, 2021", "seminar_time": "17:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "Dr", "seminar_speaker": "Gaia Colasante", "speaker_affil": "Ospedale San Raffaele", "speaker_twitter": "@ColasanteGaia", "speaker_website": "https://research.hsr.it/en/divisions/neuroscience/stem-cells-and-neurogenesis/gaia-colasante.html", "topic_tags": "epilepsy, Dravet, CRISPR", "seminar_title": "TBD", "seminar_abstract": "", "hosted_by": "Experimental Epilepsy", "domain": ["Neuroscience"], "calendar_event_hash": "3c809a90169b833292b154af6fe76c5ef7af16d469b17fa9fb0fa5d3d13195e7", "seminar_id": 309, "time_of_addition": "Fri, Jul 03, 2020 14:00"}, "310": {"seminar_date": "Wed, Jun 2, 2021", "seminar_time": "17:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Alfonso Represa", "speaker_affil": "INSERM, Institut de Neurobiologie de la M\u00e9diterran\u00e9e", "speaker_twitter": "", "speaker_website": "http://www.inmed.fr/en/en-migration-neuronale-et-pathologies-du-developpement-cerebral", "topic_tags": "epilepsy, cortical malformations, epileptogenesis", "seminar_title": "Malformation of cortical development: the genesis of epileptogenic networks", "seminar_abstract": "", "hosted_by": "Experimental Epilepsy", "domain": ["Neuroscience"], "calendar_event_hash": "6c10798fefca55196ef9ef2ce4cc28bdf49bf287314377232db62d1be18d2d50", "seminar_id": 310, "time_of_addition": "Fri, Jul 03, 2020 14:00"}, "311": {"seminar_date": "Wed, Jun 16, 2021", "seminar_time": "17:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Jeanne Paz", "speaker_affil": "UCSF", "speaker_twitter": "@JeanneTPaz", "speaker_website": "https://labs.gladstone.org/paz/", "topic_tags": "epilepsy", "seminar_title": "TBD", "seminar_abstract": "", "hosted_by": "Experimental Epilepsy", "domain": ["Neuroscience"], "calendar_event_hash": "501ff6283844f95d3bc359d06b7bed71496b62235982d4de6193355f826c8fea", "seminar_id": 311, "time_of_addition": "Fri, Jul 03, 2020 14:00"}, "312": {"seminar_date": "Wed, Jul 7, 2021", "seminar_time": "17:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Holger Lerche", "speaker_affil": "Hertie Institute for Clinical Brain Research", "speaker_twitter": "", "speaker_website": "https://www.hih-tuebingen.de/en/research/neurology-and-epileptology/", "topic_tags": "epilepsy", "seminar_title": "Mechanisms and precision therapies in genetic epilepsies", "seminar_abstract": "", "hosted_by": "Experimental Epilepsy", "domain": ["Neuroscience"], "calendar_event_hash": "ad00959df8a0ee09cbd9ac65f96e613bedd88b68989e6c46c6f182fe6fdfdcec", "seminar_id": 312, "time_of_addition": "Fri, Jul 03, 2020 14:00"}, "335": {"seminar_date": "Wed, Jul 21, 2021", "seminar_time": "14:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Jack Parent", "speaker_affil": "University of Michigan Medical School.", "speaker_twitter": "", "speaker_website": "https://theparentlab.weebly.com", "topic_tags": "epilepsy", "seminar_title": "Using Human Stem Cells to Uncover Genetic Epilepsy Mechanisms", "seminar_abstract": "", "hosted_by": "Experimental Epilepsy", "domain": ["Neuroscience"], "calendar_event_hash": "d12a2cf99354fb5188e2d5f2e909fd6d4f99f61b26e3303dbc1feabd8d000ce0", "seminar_id": 335, "time_of_addition": "Mon, Jul 06, 2020 12:30"}, "341": {"seminar_date": "Wed, Aug 4, 2021", "seminar_time": "14:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "Dr", "seminar_speaker": "Joseph Raimondo", "speaker_affil": "University of Cape Town", "speaker_twitter": "@JosephRaimondo", "speaker_website": "https://raimondolab.com/contact/", "topic_tags": "epilepsy, neuroinflammation, neurocysticercosis", "seminar_title": "Tapeworm larvae in the brain: cellular mechanisms of epilepsy in neurocysticercosis", "seminar_abstract": "", "hosted_by": "Experimental Epilepsy", "domain": ["Neuroscience"], "calendar_event_hash": "dd67bc9365e032443256df9c5fa625deb35c17721672461e336b9e4a1391e293", "seminar_id": 341, "time_of_addition": "Tue, Jul 07, 2020 13:50"}, "313": {"seminar_date": "Wed, Sep 1, 2021", "seminar_time": "14:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Kevin Staley", "speaker_affil": "MassGeneral Hospital for Children", "speaker_twitter": "", "speaker_website": "https://www.massgeneral.org/neurology/research/pediatric-epilepsy-research-lab-kevin-staley", "topic_tags": "epilepsy, interneurons, seizures, chloride, Brain Injury", "seminar_title": "Overdrawn at the ion bank: brain injury, neuronal chloride levels, and seizures", "seminar_abstract": "", "hosted_by": "Experimental Epilepsy", "domain": ["Neuroscience"], "calendar_event_hash": "90b1be0aa741459dd103d72135c3c5e2eca3cbf0b13ea6bbe3379c67ddd4ede0", "seminar_id": 313, "time_of_addition": "Fri, Jul 03, 2020 14:00"}, "342": {"seminar_date": "Wed, Sep 15, 2021", "seminar_time": "14:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Annamaria Vezzani", "speaker_affil": "Mario Negri Institute", "speaker_twitter": "", "speaker_website": "https://www.marionegri.it/laboratories/laboratory-of-experimental-neurology", "topic_tags": "epilepsy, neuroinflammation", "seminar_title": "Neuroinflammation in epilepsy: cell type specific roles and pathophysiological outcomes", "seminar_abstract": "", "hosted_by": "Experimental Epilepsy", "domain": ["Neuroscience"], "calendar_event_hash": "5df490c6f26e29da576f1865f91285956d6c6d606157d0b38f3d4fd4dc91b757", "seminar_id": 342, "time_of_addition": "Tue, Jul 07, 2020 15:00"}, "349": {"seminar_date": "Wed, Oct 20, 2021", "seminar_time": "14:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Lori Isom", "speaker_affil": "University of Michigan", "speaker_twitter": "", "speaker_website": "http://isomlabmichigan.com", "topic_tags": "epilepsy", "seminar_title": "TBD", "seminar_abstract": "", "hosted_by": "Experimental Epilepsy", "domain": ["Neuroscience"], "calendar_event_hash": "806b102b003388d776fb4e5c33fc5294c07042a87afbc99d3e3ae2e1fc2868c6", "seminar_id": 349, "time_of_addition": "Wed, Jul 08, 2020 20:05"}, "413": {"seminar_date": "Wed, Nov 3, 2021", "seminar_time": "14:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Elsa Rossignol", "speaker_affil": "University of Montreal", "speaker_twitter": "", "speaker_website": "https://www.chusj.org/Bio?id=5b83741d-1d9c-447f-8498-c8f3f5cc3126&lang=en", "topic_tags": "epilepsy", "seminar_title": "TBD", "seminar_abstract": "", "hosted_by": "Experimental Epilepsy", "domain": ["Neuroscience"], "calendar_event_hash": "332dbde4ae8ac6c76925b1387ca74565979284a6de8c4c4389285f8d8fd553fa", "seminar_id": 413, "time_of_addition": "Fri, Jul 31, 2020 09:55"}, "414": {"seminar_date": "Wed, Dec 1, 2021", "seminar_time": "14:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Mike Cousin", "speaker_affil": "University of Edinburgh", "speaker_twitter": "@theCousinLab", "speaker_website": "https://www.ed.ac.uk/discovery-brain-sciences/our-staff/research-groups/mike-cousin", "topic_tags": "epilepsy", "seminar_title": "Dysfunctional synaptic vesicle recycling \u2013 links to epilepsy", "seminar_abstract": "", "hosted_by": "Experimental Epilepsy", "domain": ["Neuroscience"], "calendar_event_hash": "5657b96a404f640a863843fa4b9d2ab3b6eb1b5300d82b07f6d8de83aad68be2", "seminar_id": 414, "time_of_addition": "Fri, Jul 31, 2020 09:55"}, "350": {"seminar_date": "Wed, Dec 15, 2021", "seminar_time": "14:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Amy Brooks-Kayal", "speaker_affil": "Children's Hospital Colorado / UC Davis", "speaker_twitter": "", "speaker_website": "https://www.childrenscolorado.org/doctors-and-departments/physicians/b/amy-brooks-kayal/", "topic_tags": "epilepsy, epilpetogenesis", "seminar_title": "JAK/STAT regulation of the transcriptomic response during epileptogenesis", "seminar_abstract": "", "hosted_by": "Experimental Epilepsy", "domain": ["Neuroscience"], "calendar_event_hash": "0392338e657167c83adfe89b254c12d24bf2dcc88356523b511f70d1a9701b55", "seminar_id": 350, "time_of_addition": "Wed, Jul 08, 2020 20:05"}, "671": {"seminar_date": "Tues, Oct 13, 2020", "seminar_time": "16:00", "timezone": "Europe/London", "posted": "Yes", "seminar_link": "https://us02web.zoom.us/meeting/register/tZcrf-ytrzktE92ELCxy8iJ_rV0BgXQRYw_J", "password": "", "video_on_demand": "", "speaker_title": "Prof.", "seminar_speaker": "Paul Fletcher", "speaker_affil": "Department of Psychiatry, University of Cambridge", "speaker_twitter": "", "speaker_website": "", "topic_tags": "COVID-19, mental health", "seminar_title": "Is the COVID-19 pandemic really causing mental illness?", "seminar_abstract": "", "hosted_by": "CamNeuro Interdisiciplinary Seminar Series", "domain": ["Neuroscience"], "calendar_event_hash": "359a479680f16ce8fd28ee34ceb05bb3355617606c13c32d0cb8168487f37abc", "seminar_id": 671, "time_of_addition": "Tue, Sep 15, 2020 19:05"}, "672": {"seminar_date": "Tues, Oct 20, 2020", "seminar_time": "16:00", "timezone": "Europe/London", "posted": "Yes", "seminar_link": "https://us02web.zoom.us/meeting/register/tZEpdOuupzgpHdxUVI5BqqgfF24WMrrWIxMx", "password": "", "video_on_demand": "", "speaker_title": "Prof.", "seminar_speaker": "David Menon", "speaker_affil": "Department of Anaethesia, University of Cambridge", "speaker_twitter": "", "speaker_website": "", "topic_tags": "COVID-19, neurology", "seminar_title": "NeuroCOVID: Epidemiology, biomarkers, and pathophysiology", "seminar_abstract": "", "hosted_by": "CamNeuro Interdisiciplinary Seminar Series", "domain": ["Neuroscience"], "calendar_event_hash": "e0ad7744891cb2cd20d84b82ffc40aa3f3cc101ff66f75b83cb374644a2a9e69", "seminar_id": 672, "time_of_addition": "Tue, Sep 15, 2020 19:05"}, "673": {"seminar_date": "Tues, Oct 27, 2020", "seminar_time": "16:00", "timezone": "Europe/London", "posted": "Yes", "seminar_link": "https://us02web.zoom.us/meeting/register/tZMud-2trTwpH9OB-2cy7tr8RwSO3N7T4Ens", "password": "", "video_on_demand": "", "speaker_title": "Prof.", "seminar_speaker": "Tamsin Ford", "speaker_affil": "Department of Psychiatry, University of Cambridge", "speaker_twitter": "", "speaker_website": "", "topic_tags": "COVID-19, mental health, adolescents", "seminar_title": "The impact of Covid-19 on the mental health of children and young people", "seminar_abstract": "The recent pandemic arrived at a time when mental health of children and young people was deteriorating, particular among teenage girls and young women. Lockdown produced a plethora of mental health surveys, but very few of these had pre-pandemic data. This talk will summarise the current evidence of how covid-19 seems to have affected the mental health of children and young people from various studies in the UK.", "hosted_by": "CamNeuro Interdisiciplinary Seminar Series", "domain": ["Neuroscience"], "calendar_event_hash": "16a4bc5dfddc64a7c01e3066680a0db2e0d9edafdd56b1270302d96ba63cb0d7", "seminar_id": 673, "time_of_addition": "Tue, Sep 15, 2020 19:05"}, "674": {"seminar_date": "Mon, Nov 2, 2020", "seminar_time": "16:00", "timezone": "Europe/London", "posted": "Yes", "seminar_link": "https://us02web.zoom.us/meeting/register/tZwvdeytpj8uGdHFypqrW5yXer8MDaelvocB", "password": "", "video_on_demand": "", "speaker_title": "Prof.", "seminar_speaker": "Carol Brayne", "speaker_affil": "Department of Public Health and Primary Care, University of Cambridge", "speaker_twitter": "", "speaker_website": "", "topic_tags": "COVID-19, public health", "seminar_title": "Population studies and ageing brains, in a time of COVID", "seminar_abstract": "This presentation will include a brief resume of research in older populations led from Cambridge that have informed current clinical understanding and policy regarding services and prevention for and of dementia. These population studies have more recently been \u2018re-purposed\u2019 with enthusiasm from participants into a trial platform, and this also has enabled ongoing follow-up by telephone during the COVID pandemic. Although there are no formal outputs from these latter developments general impressions will be shared.", "hosted_by": "CamNeuro Interdisiciplinary Seminar Series", "domain": ["Neuroscience"], "calendar_event_hash": "e2c4e993769294e4cea5cd5c0124a7019a060631adde4c88aa4975d7cb43fb85", "seminar_id": 674, "time_of_addition": "Tue, Sep 15, 2020 19:05"}, "675": {"seminar_date": "Tues, Nov 10, 2020", "seminar_time": "16:00", "timezone": "Europe/London", "posted": "Yes", "seminar_link": "https://us02web.zoom.us/meeting/register/tZ0kd\u2014prT8iG9fnX2QACStVR-fzVRtJqB6u", "password": "", "video_on_demand": "", "speaker_title": "Dr.", "seminar_speaker": "Rudolf Cardinal", "speaker_affil": "Department of Psychiatry, University of Cambridge", "speaker_twitter": "", "speaker_website": "", "topic_tags": "COVID-19, public health, epidemiology", "seminar_title": "The early impact of COVID-19 on mental health and community physical health services and their patients\u2019 mortality in Cambridgeshire and Peterborough, UK", "seminar_abstract": "COVID -19 has affected social interaction and healthcare worldwide. This talk will focus on the impact of the pandemic and \u201clockdown\u201d on mental health services, community physical health services, and patient mortality in Cambridgeshire and Peterborough, based on the analysis of de-identified data from the primary NHS provider of secondary care mental health services to this population (~0.86 million)", "hosted_by": "CamNeuro Interdisiciplinary Seminar Series", "domain": ["Neuroscience"], "calendar_event_hash": "512db6d72fdb7d6ceb2e324eb924266d41670291e4519a210c615da4887812e3", "seminar_id": 675, "time_of_addition": "Tue, Sep 15, 2020 19:05"}, "676": {"seminar_date": "Tues, Nov 17, 2021", "seminar_time": "16:00", "timezone": "Europe/London", "posted": "Yes", "seminar_link": "https://us02web.zoom.us/meeting/register/tZEpfuyspzwjEtRsQUIaXkZjXsG5fXTaex6H", "password": "", "video_on_demand": "", "speaker_title": "Dr.", "seminar_speaker": "David Belin", "speaker_affil": "Department of Psychology, University of Cambridge", "speaker_twitter": "", "speaker_website": "", "topic_tags": "COVID-19", "seminar_title": "Social deprivation, coping and drugs: a bad cocktail in the COVID-19 era: evidence from preclinical studies", "seminar_abstract": "The factors that underlie an individual\u2019s vulnerability to switch from controlled, recreational drug use to addiction are not well understood. I will discuss the evidence in rats that in individuals housed in enriched conditions, the experience of drugs in the relative social and sensory impoverishment of the drug taking context, and the associated change in behavioural traits of resilience to addiction, exacerbate the vulnerability to develop compulsive drug intake. I will further discuss the importance of the acquisition of alcohol drinking as a mechanism to cope with distress as a factor of exacerbated vulnerability to develop compulsive alcohol intake. Together these results demonstrate that experiential factors in the drug taking context, which can be substantially driven by social isolation, shape the vulnerability to addiction.", "hosted_by": "CamNeuro Interdisiciplinary Seminar Series", "domain": ["Neuroscience"], "calendar_event_hash": "57b4843771a47aab4f17473846bfb336d2295c1260bd7c59da2835ba1dff4baa", "seminar_id": 676, "time_of_addition": "Tue, Sep 15, 2020 19:05"}, "677": {"seminar_date": "Tues, Nov 24, 2020", "seminar_time": "16:00", "timezone": "Europe/London", "posted": "Yes", "seminar_link": "https://us02web.zoom.us/meeting/register/tZAvf-qtrz0sHNYXr1FDH0DSfKn5bVY8zGEq", "password": "", "video_on_demand": "", "speaker_title": "Prof.", "seminar_speaker": "Sarah-Jayne Blakemore", "speaker_affil": "Department of Psychology, University of Cambridge", "speaker_twitter": "", "speaker_website": "", "topic_tags": "COVID-19, mental health, adolescents", "seminar_title": "Development of the social brain in adolescence and effects of social distancing", "seminar_abstract": "Adolescence is a period of life characterised by heightened sensitivity to social stimuli, an increased need for peer interaction and peer acceptance, and development of the social brain. Lockdown and social distancing measures intended to mitigate the spread of COVID-19 are reducing the opportunity to engage in face-to-face social interaction with peers. The consequences of social distancing on human social brain and social cognitive development are unknown, but animal research has shown that social deprivation and isolation have unique effects on brain and behaviour in adolescence compared with other stages of life. It is possible that social distancing might have a disproportionate effect on an age group for whom peer interaction is a vital aspect of development.", "hosted_by": "CamNeuro Interdisiciplinary Seminar Series", "domain": ["Neuroscience"], "calendar_event_hash": "a26a18c6876259e6bb1047b1f758579ed4a700ef8ad7579ef195faa2130109e3", "seminar_id": 677, "time_of_addition": "Tue, Sep 15, 2020 19:05"}, "749": {"seminar_date": "Tues, Dec 1, 2020", "seminar_time": "16:00", "timezone": "Europe/London", "posted": "Yes", "seminar_link": "https://us02web.zoom.us/meeting/register/tZYqc-ihrzgtEtYdoccCL09rFt1qyqca9jFg", "password": "", "video_on_demand": "", "speaker_title": "Prof.", "seminar_speaker": "Topun Austin", "speaker_affil": "Cambridge University Hospitals NHS Foundation Trust", "speaker_twitter": "", "speaker_website": "", "topic_tags": "COVID-19, maternity", "seminar_title": "Generation Covid-19: Should the fetus be worried?", "seminar_abstract": "Historically pregnant women and their unborn baby have been amongst those with the poorest outcomes in previous epidemics, most notably the Zika virus. For much of 2020, with the emergence of the novel coronavirus, the effect on the fetus remains unclear. While initial reports suggest that vertical transmission with SARS-CoV2 is reassuringly rare, the complex socioeconomic, domestic and broader maternal lifestyle factors which can influence a child\u2019s lifelong well-being have been modulated during the experience of this pandemic. The developing brain is particularly susceptible to maternal stress, resulting in permanent structural changes and increased incidence of behavioural and mental health illness later in childhood. A large international longitudinal survey is being undertaken by the Department of Psychology to better understand the impact of the pandemic on those yet to be born.", "hosted_by": "CamNeuro Interdisiciplinary Seminar Series", "domain": ["Neuroscience"], "calendar_event_hash": "8a093f5f3096d1a83eef97bb1ac566c910064b5e7bd3b41196a54b2828eca91b", "seminar_id": 749, "time_of_addition": "Thu, Sep 24, 2020 10:35"}, "325": {"seminar_date": "Fri, Apr 24, 2020", "seminar_time": "13:00", "timezone": "America/New_York", "posted": "yes", "seminar_link": "https://osu.zoom.us/j/395198659", "password": "", "video_on_demand": "https://www.youtube.com/watch?v=zwjaseugjVo", "speaker_title": "Dr", "seminar_speaker": "Xiangrui Li", "speaker_affil": "Ohio State University", "speaker_twitter": "", "speaker_website": "https://ccbbi.osu.edu/", "topic_tags": "fMRI", "seminar_title": "Tips of MRI Data Acquisition at CCBBI", "seminar_abstract": "MRI data quality is crucial to the result. This workshop talks some aspects we need to pay attention during the data acquisition, including FoV/slice brain coverage, synchronization between image acquisition and stimulus presentation, instruction to participant, real time quality monitoring, the usage of physiological data. Prior to the meeting, we are collecting questions for Xiangrui on anything related to mri protocol/parameters: https://www.tricider.com/admin/2YW93TsWZJ3/2DBkJUoE5Ot", "hosted_by": "Imaging Ohio", "domain": ["Neuroscience"], "calendar_event_hash": "c1a58505cd8c02093aca046d3fd89f4e525de5d4fc30807703ae7941b83be7d3", "seminar_id": 325, "time_of_addition": "Fri, Jul 03, 2020 14:00"}, "326": {"seminar_date": "Fri, Jul 24, 2020", "seminar_time": "13:00", "timezone": "America/New_York", "posted": "yes", "seminar_link": "https://osu.zoom.us/j/395198659", "password": "", "video_on_demand": "", "speaker_title": "Dr", "seminar_speaker": "Xiangrui Li", "speaker_affil": "Ohio State University", "speaker_twitter": "", "speaker_website": "https://bit.ly/matlabimaging", "topic_tags": "matlab, fMRI, neuroimaging", "seminar_title": "Matlab in neuroimaging (Part 3): Image analysis in Matlab", "seminar_abstract": "Last in a three-part lecture series about using matlab in neuroimaging. For full details go here: https://bit.ly/matlabimaging", "hosted_by": "Imaging Ohio", "domain": ["Neuroscience"], "calendar_event_hash": "a6b58e3ba4bd557fc852ad2bed541463e02ae58267c962592b73addb1a850736", "seminar_id": 326, "time_of_addition": "Fri, Jul 03, 2020 14:00"}, "327": {"seminar_date": "Fri, Jul 10, 2020", "seminar_time": "13:00", "timezone": "America/New_York", "posted": "yes", "seminar_link": "https://osu.zoom.us/j/395198659", "password": "", "video_on_demand": "", "speaker_title": "Dr", "seminar_speaker": "Xiangrui Li", "speaker_affil": "Ohio State University", "speaker_twitter": "", "speaker_website": "https://bit.ly/matlabimaging", "topic_tags": "matlab, fMRI, neuroimaging", "seminar_title": "Matlab in neuroimaging (Part 1): Matlab basics", "seminar_abstract": "First in a three-part lecture series about using matlab in neuroimaging. For full details go here: https://bit.ly/matlabimaging", "hosted_by": "Imaging Ohio", "domain": ["Neuroscience"], "calendar_event_hash": "4ddbf18b64f2894ef1e5e042e7ebc1f61c4151c43470d4210310dd6de3b67ab7", "seminar_id": 327, "time_of_addition": "Fri, Jul 03, 2020 14:00"}, "328": {"seminar_date": "Fri, Jul 17, 2020", "seminar_time": "13:00", "timezone": "America/New_York", "posted": "yes", "seminar_link": "https://osu.zoom.us/j/395198659", "password": "", "video_on_demand": "", "speaker_title": "Dr", "seminar_speaker": "Xiangrui Li", "speaker_affil": "Ohio State University", "speaker_twitter": "", "speaker_website": "https://mailchi.mp/b3f65bbc346d/onneuro-7885485", "topic_tags": "matlab, fMRI, neuroimaging", "seminar_title": "Matlab in neuroimaging (Part 2): Stimulus presentation and response collection with Psychtoolbox", "seminar_abstract": "Second in a three-part lecture series about using matlab in neuroimaging. For full details: https://mailchi.mp/b3f65bbc346d/onneuro-7885485", "hosted_by": "Imaging Ohio", "domain": ["Neuroscience"], "calendar_event_hash": "98553dfe14878fb53484fd095c1bcde08c7a109a8a113d8beb243db3220e5451", "seminar_id": 328, "time_of_addition": "Fri, Jul 03, 2020 14:00"}, "866": {"seminar_date": "Thu, May 7, 2020", "seminar_time": "16:00", "timezone": "America/New_York", "posted": "yes", "seminar_link": "https://mit.zoom.us/j/91451494597", "password": "", "video_on_demand": "https://vimeo.com/416435315", "speaker_title": "Prof", "seminar_speaker": "Earl Miller", "speaker_affil": "Picower Institute, MIT", "speaker_twitter": "@MIT_Picower", "speaker_website": "https://picower.mit.edu/earl-k-miller", "topic_tags": "cortex, systems", "seminar_title": "Working Memory 2.0", "seminar_abstract": "Working memory is the sketchpad of consciousness, the fundamental mechanism the brain uses to gain volitional control over its thoughts and actions. For the past 50 years, working memory has been thought to rely on cortical neurons that fire continuous impulses that keep thoughts \u201conline\u201d. However, new work from our lab has revealed more complex dynamics. The impulses fire sparsely and interact with brain rhythms of different frequencies. Higher frequency gamma (> 35 Hz) rhythms help carry the contents of working memory while lower frequency alpha/beta (~8-30 Hz) rhythms act as control signals that gate access to and clear out working memory. In other words, a rhythmic dance between brain rhythms may underlie your ability to control your own thoughts.", "hosted_by": "MIT Brain & Cog Sci", "domain": ["Neuroscience"], "calendar_event_hash": "6829684c61c6c4bf90367df2072dc3a5b1f48bf93eff5df868a60e5cdcd3a910", "seminar_id": 866, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "867": {"seminar_date": "Thu, May 14, 2020", "seminar_time": "16:00", "timezone": "America/New_York", "posted": "yes", "seminar_link": "https://mit.zoom.us/j/92153793477", "password": "", "video_on_demand": "https://youtu.be/MX_Tx2pRkYk", "speaker_title": "Prof", "seminar_speaker": "Guoping Feng", "speaker_affil": "MIT Dept. of Brain and Cognitive Sciences", "speaker_twitter": "", "speaker_website": "https://fenglaboratory.org/", "topic_tags": "neurodevelopmental disorders, imaging, behaviour, electrophysiology", "seminar_title": "Thalamic reticular nucleus dysfunction in neurodevelopmental disorders", "seminar_abstract": "The thalamic reticular nucleus (TRN), the major source of thalamic inhibition, is known to regulate thalamocortical interactions critical for sensory processing, attention and cognition. TRN dysfunction has been linked to sensory abnormality, attention deficit and sleep disturbance across multiple neurodevelopmental disorders. Currently, little is known about the organizational principles underlying its divergent functions. In this talk, I will start with an example of how dysfunction of TRN contributes to attention deficit and sleep disruption using a mouse model of Ptchd1 mutation, which in humans cause neurodevelopmental disorder with ASD. Building on these findings, we further performed an integrative single-cell analysis linking molecular and electrophysiological features of the TRN to connectivity and systems-level function. We identified two subnetworks of the TRN with segregated anatomical structure, distinct electrophysiological properties, differential connections to the functionally distinct first-order and higher-order thalamic nuclei, and differential role in regulating sleep. These studies provide a comprehensive atlas for TRN neurons at the single-cell resolution and a foundation for studying diverse functions and dysfunctions of the TRN. Finally, I will describe the newly developed minimally invasive optogenetic tool for probing circuit function and dysfunction.", "hosted_by": "MIT Brain & Cog Sci", "domain": ["Neuroscience"], "calendar_event_hash": "94b273c5079866e59525aaf239ddc77047407fb7decd85428b36add1a447546c", "seminar_id": 867, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "868": {"seminar_date": "Thu, May 21, 2020", "seminar_time": "16:00", "timezone": "America/New_York", "posted": "yes", "seminar_link": "https://mit.zoom.us/j/97608996526", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Mriganka Sur", "speaker_affil": "MIT Department of Brain and Cognitive Sciences", "speaker_twitter": "@surlabmit", "speaker_website": "", "topic_tags": "plasticity, development", "seminar_title": "Cortical plasticity", "seminar_abstract": "Plasticity shapes the brain during development, and mechanisms of plasticity continue into adulthood to enable learning and memory. Nearly all brain functions are influenced by past events, reinforcing the view that the confluence of plasticity and computation in the same circuit elements is a core component of biological intelligence. My laboratory studies plasticity in the cerebral cortex during development, and plasticity during behaviour that is manifest as cortical dynamics. I will describe how cortical plasticity is implemented by learning rules that involve not only Hebbian changes and synaptic scaling but also dendritic renormalization. By using advanced techniques such as optical measurements of single-synapse function and structure in identified neurons in awake behaving mice, we have recently demonstrated locally coordinated plasticity in dendrites whereby specific synapses are strengthened and adjacent synapses with complementary features are weakened. Together, these changes cooperatively implement functional plasticity in neurons. Such plasticity relies on the dynamics of activity-dependent molecules within and between synapses. Alongside, it is increasingly clear that risk genes associated with neurodevelopmental disorders disproportionately target molecules of plasticity. Deficits in renormalization contribute fundamentally to dysfunctional neuronal circuits and computations, and may be a unifying mechanistic feature of these disorders.", "hosted_by": "MIT Brain & Cog Sci", "domain": ["Neuroscience"], "calendar_event_hash": "402f34b741a5c784aec8575c17435f942e3439da236c611fe25e224804d9312d", "seminar_id": 868, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "869": {"seminar_date": "Thu, May 28, 2020", "seminar_time": "16:00", "timezone": "America/New_York", "posted": "yes", "seminar_link": "https://mit.zoom.us/j/92346493144", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Nancy Kanwisher", "speaker_affil": "MIT Department of Brain and Cognitive Sciences", "speaker_twitter": "", "speaker_website": "https://web.mit.edu/bcs/nklab/index.shtml", "topic_tags": "cognition, systems, neural networks, recognition", "seminar_title": "Domain Specificity in the Human Brain: What, Whether, and Why?", "seminar_abstract": "The last quarter century has provided extensive  evidence that some regions of the human cortex are selectively engaged in processing a single specific domain of information, from faces, places, and bodies to language, music, and other people\u2019s thoughts. This work dovetails with earlier theories in cognitive science highlighting domain specificity in human cognition, development, and evolution. But many questions remain unanswered about even the clearest cases of domain specificity in the brain, the selective engagement of the FFA, PPA, and EBA in the perception of faces, places, and bodies, respectively. First, these claims lack precision, saying little about what is computed and how, and relying on human judgements to decide what counts as a face, place, or body. Second, they provide no account of the reliably varying responses of these regions across different \u201cpreferred\u201d images, or across different \u201cnonpreferred\u201d images for each category. Third, the category selectivity of each region is vulnerable to refutation if any of the vast set of as-yet-untested nonpreferred images turns out to produce a stronger response than preferred images for that region. Fourth, and most fundamentally, they provide no account of why, from a computational point of view, brains should exhibit this striking degree of functional specificity in the first place, and why we should have the particular visual specializations we do, for faces, places, and bodies, but not (apparently) for food or snakes. The advent of convolutional neural networks (CNNs) to model visual processing in the ventral pathway has opened up many opportunities to address these long-standing questions in new ways. I will describe ongoing efforts in our lab to harness CNNs to do just that.", "hosted_by": "MIT Brain & Cog Sci", "domain": ["Neuroscience"], "calendar_event_hash": "82ba3c035e8ac9587f67932ed843fe27c9324d14f92a791070e1372d433169de", "seminar_id": 869, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "891": {"seminar_date": "Thu, Jul 2, 2020", "seminar_time": "16:00", "timezone": "Europe/Berlin", "posted": "yes", "seminar_link": "https://mpibox.mpib-berlin.mpg.de/f/f895419c2de945feb197/?dl=1", "password": "", "video_on_demand": "", "speaker_title": "Prof.", "seminar_speaker": "Lars Nyberg", "speaker_affil": "Umea University", "speaker_twitter": "", "speaker_website": "https://www.umu.se/en/staff/lars-nyberg/", "topic_tags": "", "seminar_title": "Lifespan Maintenance of Brain and Cognition - Fiction or Science", "seminar_abstract": "", "hosted_by": "LIFE Theory Lab 2020", "domain": ["Neuroscience"], "calendar_event_hash": "eda44ec238f80059cf578dfaa88839d908ea973a641126fa6516ad730c34eea7", "seminar_id": 891, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "892": {"seminar_date": "Thu, Jul 9, 2020", "seminar_time": "14:00", "timezone": "Europe/Berlin", "posted": "yes", "seminar_link": "https://mpibox.mpib-berlin.mpg.de/f/f895419c2de945feb197/?dl=1", "password": "", "video_on_demand": "", "speaker_title": "Prof.", "seminar_speaker": "Gerd Kempermann", "speaker_affil": "Center for Regenerative Therapies Dresden", "speaker_twitter": "", "speaker_website": "https://www.crt-dresden.de/de/forschung/research-groups/core-groups/group-leaders/prof-dr-gerd-kempermann/", "topic_tags": "", "seminar_title": "Adult Neurogenesis, Enriched Environments, and the Neurobiology of Early Life-style Dependent Resilience", "seminar_abstract": "", "hosted_by": "LIFE Theory Lab 2020", "domain": ["Neuroscience"], "calendar_event_hash": "3bf20bba8a9d6a1d5106cd830d556ac2ef8f26c0ca39ac9fd857f419870bda3a", "seminar_id": 892, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "893": {"seminar_date": "Thu, Jul 16, 2020", "seminar_time": "14:00", "timezone": "Europe/Berlin", "posted": "yes", "seminar_link": "https://mpibox.mpib-berlin.mpg.de/f/f895419c2de945feb197/?dl=1", "password": "", "video_on_demand": "", "speaker_title": "Prof.", "seminar_speaker": "Danielle Bassett", "speaker_affil": "University of Pennsylvania", "speaker_twitter": "", "speaker_website": "https://complexsystemsupenn.com/", "topic_tags": "", "seminar_title": "Structure-Function Couplings in Human Brain Development", "seminar_abstract": "", "hosted_by": "LIFE Theory Lab 2020", "domain": ["Neuroscience"], "calendar_event_hash": "2b95af52032439e46a12ec1f307b782c26d45da23c6d98a33b3dfa2336318fbf", "seminar_id": 893, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "894": {"seminar_date": "Thu, Jul 23, 2020", "seminar_time": "14:00", "timezone": "Europe/Berlin", "posted": "yes", "seminar_link": "https://mpibox.mpib-berlin.mpg.de/f/f895419c2de945feb197/?dl=1", "password": "", "video_on_demand": "", "speaker_title": "Prof.", "seminar_speaker": "Iyad Rahwan", "speaker_affil": "Max Planck Institute for Human Development", "speaker_twitter": "", "speaker_website": "https://www.mpib-berlin.mpg.de/staff/iyad-rahwan.html", "topic_tags": "", "seminar_title": "Machine behavior: A Research Agenda for a Society Permeated by Artificial Intelligence", "seminar_abstract": "", "hosted_by": "LIFE Theory Lab 2020", "domain": ["Neuroscience"], "calendar_event_hash": "3a31d0c80c5c6ae3188d2c394943571a46679d373e4f90e1607427cec1dabf5b", "seminar_id": 894, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "895": {"seminar_date": "Thu, Jul 30, 2020", "seminar_time": "14:00", "timezone": "Europe/Berlin", "posted": "yes", "seminar_link": "https://mpibox.mpib-berlin.mpg.de/f/f895419c2de945feb197/?dl=1", "password": "", "video_on_demand": "", "speaker_title": "Prof.", "seminar_speaker": "Ellen Hamaker", "speaker_affil": "Utrecht University", "speaker_twitter": "", "speaker_website": "https://dml.sites.uu.nl/people/ellen-hamaker/", "topic_tags": "", "seminar_title": "Choices in Design and Analysis to Study Change", "seminar_abstract": "", "hosted_by": "LIFE Theory Lab 2020", "domain": ["Neuroscience"], "calendar_event_hash": "9e218057ef32a7a2af94e266e4ee6340d1fca43c97ed316a233b6576118b9bca", "seminar_id": 895, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "896": {"seminar_date": "Thu, Aug 6, 2020", "seminar_time": "14:00", "timezone": "Europe/Berlin", "posted": "yes", "seminar_link": "https://mpibox.mpib-berlin.mpg.de/f/f895419c2de945feb197/?dl=1", "password": "", "video_on_demand": "", "speaker_title": "Prof.", "seminar_speaker": "Ulman Lindenberger", "speaker_affil": "Max Planck Institute for Human Development", "speaker_twitter": "", "speaker_website": "https://www.mpib-berlin.mpg.de/staff/ulman-lindenberger", "topic_tags": "", "seminar_title": "Why We Need a Lifespan Approach to Developmental Change", "seminar_abstract": "", "hosted_by": "LIFE Theory Lab 2020", "domain": ["Neuroscience"], "calendar_event_hash": "d99f5022da00e7d23bfd38ac74e689ee31d161b1b093bd11a87a40f286a3e385", "seminar_id": 896, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "836": {"seminar_date": "Mon, Jun 22, 2020", "seminar_time": "09:00", "timezone": "America/Los_Angeles", "posted": "yes", "seminar_link": "https://chapman.zoom.us/webinar/register/WN_PX-mh908RoClldZd2tIKiA", "password": "", "video_on_demand": "https://www.youtube.com/watch?v=U75EaQ_gXtU", "speaker_title": "Prof.", "seminar_speaker": "John-Dylan Haynes/Walter Sinnott-Armstrong", "speaker_affil": "Charit\u00e9 - Universit\u00e4tsmedizin Berlin/Duke University", "speaker_twitter": "@johndylanhaynes", "speaker_website": "", "topic_tags": "free will, responsibility", "seminar_title": "Responsibility Without Freedom", "seminar_abstract": "", "hosted_by": "NeuroPhilosophy of Free Will", "domain": ["Neuroscience"], "calendar_event_hash": "e5097b0b07dd797527c97a76ee0a2e8264931dafd9f45b31135ce617f5ca64db", "seminar_id": 836, "time_of_addition": "Mon, Sep 28, 2020 11:06"}, "837": {"seminar_date": "Wed, Jul 1, 2020", "seminar_time": "10:30", "timezone": "America/Los_Angeles", "posted": "yes", "seminar_link": "https://chapman.zoom.us/webinar/register/WN_2lWsCwZiRFSwUCTYhhRZQg", "password": "", "video_on_demand": "https://www.youtube.com/watch?v=SGwUN12lqIs", "speaker_title": "Prof.", "seminar_speaker": "William Newsome", "speaker_affil": "Stanford University", "speaker_twitter": "", "speaker_website": "https://neuroscience.stanford.edu/people/william-newsome-0", "topic_tags": "cognitive neuroscience, decision-making, visual", "seminar_title": "Detecting Covert Cognitive States from Neural Population Recordings in Prefrontal Cortex", "seminar_abstract": "The neural mechanisms underlying decision-making are typically examined by statistical analysis of large numbers of trials from sequentially recorded single neurons. Averaging across sequential recordings, however, obscures important aspects of decision-making such as variations in confidence and 'changes of mind' (CoM) that occur at variable times on different trials. I will show that the covert decision variables (DV) can be tracked dynamically on single behavioral trials via simultaneous recording of large neural populations in prefrontal cortex. Vacillations of the neural DV, in turn, identify candidate CoM in monkeys, which closely match the known properties of human CoM. Thus simultaneous population recordings can provide insight into transient, internal cognitive states that are otherwise undetectable.", "hosted_by": "NeuroPhilosophy of Free Will", "domain": ["Neuroscience"], "calendar_event_hash": "7b7b3c143612298f587ef1bac8fc829bd54812565bcb19cea2d9ae1da146757f", "seminar_id": 837, "time_of_addition": "Mon, Sep 28, 2020 11:06"}, "629": {"seminar_date": "Fri, Jul 3, 2020", "seminar_time": "10:30", "timezone": "America/Los_Angeles", "posted": "yes", "seminar_link": "https://chapman.zoom.us/webinar/register/6515934486245/WN_bjXNCBWvTwip8xICpL7UwQ", "password": "", "video_on_demand": "https://www.youtube.com/watch?v=zrqCsaEKiT0", "speaker_title": "Prof.", "seminar_speaker": "Chandra Sripada", "speaker_affil": "University of Michigan", "speaker_twitter": "@chandra_sripada", "speaker_website": "https://sites.lsa.umich.edu/sripada/", "topic_tags": "consciousness, agency, cognitive neuroscience", "seminar_title": "Agency in the Stream of Consciousness: Perspectives from Cognitive Science and Buddhist Psychology", "seminar_abstract": "The stream of consciousness refers to ideas, images, and memories that meander across the mind when we are otherwise unoccupied. The standard view is that these thoughts are associationistic in character and they arise from subpersonal processes\u2014we are for the most part passive observers of them. Drawing on a series of laboratory studies we have conducted as well as Buddhist models of mind, I argue that these views are importantly incorrect. On the alternative view I put forward, these thoughts arise from minimal decision processes, which lie in a grey zone: They are both manifestations of agency as well as obstacles to it.", "hosted_by": "NeuroPhilosophy of Free Will", "domain": ["Neuroscience"], "calendar_event_hash": "ede5f87cf700c68b1e453dc2cbf409d2a7950f0c1361524bb7713fe606f813e5", "seminar_id": 629, "time_of_addition": "Wed, Sep 09, 2020 13:30"}, "630": {"seminar_date": "Mon, Jul 20, 2020", "seminar_time": "10:00", "timezone": "America/Los_Angeles", "posted": "yes", "seminar_link": "https://chapman.zoom.us/webinar/register/7015930412275/WN_WkAOr5A6Qd6mhqYV5oumBA", "password": "", "video_on_demand": "", "speaker_title": "Prof.", "seminar_speaker": "Aaron Schurger/Adina Roskies", "speaker_affil": "Chapman University/Dartmouth College", "speaker_twitter": "", "speaker_website": "https://neurophil-freewill.org/people/", "topic_tags": "readiness potential, volition, consciousness", "seminar_title": "The Readiness Potential: What Does It Mean for Conscious Volition?", "seminar_abstract": "", "hosted_by": "NeuroPhilosophy of Free Will", "domain": ["Neuroscience"], "calendar_event_hash": "7f213a62c33448ac5a991ce24b6723b56c25cf6d70d4e6bc02c76985e9cf35c4", "seminar_id": 630, "time_of_addition": "Wed, Sep 09, 2020 13:30"}, "680": {"seminar_date": "Fri, Oct 16, 2020", "seminar_time": "11:00", "timezone": "America/Los_Angeles", "posted": "yes", "seminar_link": "https://chapman.zoom.us/webinar/register/8116003147432/WN_jTYRml1kR6GUmklc_xM-uQ", "password": "", "video_on_demand": "", "speaker_title": "Prof.", "seminar_speaker": "John Assad/Manuel Vargas", "speaker_affil": "Harvard Medical School/UC San Diego", "speaker_twitter": "", "speaker_website": "https://neurophil-freewill.org/events/", "topic_tags": "free will, neurobiology, philosophy, action, volition", "seminar_title": "The Power and Limits of Neuroscience Research Paradigms on Action and Free Will", "seminar_abstract": "", "hosted_by": "NeuroPhilosophy of Free Will", "domain": ["Neuroscience"], "calendar_event_hash": "f1f3d731a6edbc1f06c44d90a823cdc2d8129781679b066b6c5903cc00b1c8f0", "seminar_id": 680, "time_of_addition": "Thu, Sep 17, 2020 06:25"}, "872": {"seminar_date": "Fri, Apr 24, 2020", "seminar_time": "14:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://www.youtube.com/watch?v=sB29yq-ewYI&feature=youtu.be", "password": "", "video_on_demand": "https://youtu.be/sB29yq-ewYI", "speaker_title": "Dr", "seminar_speaker": "Jeffrey Diamond", "speaker_affil": "NIH Bethesda", "speaker_twitter": "", "speaker_website": "https://irp.nih.gov/pi/jeffrey-diamond", "topic_tags": "retina, vision, two-photon imaging, systems", "seminar_title": "Diverse synaptic mechanisms underlie visual signaling in the retina", "seminar_abstract": "Our laboratory seeks to understand how neural circuits receive, compute, encode and transmit information. More specifically, we\u2019d like to learn what biophysical and morphological features equip synapses, neurons and networks to perform these tasks. The retina is a model system for the study of neuronal information processing: We can deliver precisely defined physiological stimuli and record responses from many different cell types at various points within the network; in addition, retinal circuitry is particularly well understood, enabling us to interpret more directly the impact of synaptic and cellular mechanisms on circuit function. I will present recent experiments in the lab that exploit these advantages to examine how synapses and neurons within retinal amacrine cell circuits perform specific visual computations.", "hosted_by": "Sussex Visions", "domain": ["Neuroscience"], "calendar_event_hash": "f6e57b417c3ab0b46dec781c1fc818adc9d8393aae78a0f6e5e435d493b2a872", "seminar_id": 872, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "873": {"seminar_date": "Mon, May 11, 2020", "seminar_time": "15:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://youtu.be/n_GSNV-waHQ", "password": "", "video_on_demand": "https://www.youtube.com/watch?v=n_GSNV-waHQ&t=138s", "speaker_title": "Dr", "seminar_speaker": "Gautam Awatramani", "speaker_affil": "University of Victoria", "speaker_twitter": "", "speaker_website": "https://awatramani.weebly.com/index.html", "topic_tags": "retina, vision, systems, electrophysiology, two-photon imaging", "seminar_title": "The subcellular organization of excitation and inhibition underlying high-fidelity direction coding in the retina", "seminar_abstract": "Understanding how neural circuits in the brain compute information not only requires determining how individual inhibitory and excitatory elements of circuits are wired together, but also a detailed knowledge of their functional interactions. Recent advances in optogenetic techniques and mouse genetics now offer ways to specifically probe the functional properties of neural circuits with unprecedented specificity. Perhaps one of the most heavily interrogated circuits in the mouse brain is one in the retina that is involved in coding direction (reviewed by Mauss et al., 2017; Vaney et al., 2012). In this circuit, direction is encoded by specialized direction-selective (DS) ganglion cells (DSGCs), which respond robustly to objects moving in a \u2018preferred\u2019 direction but not in the opposite or \u2018null\u2019 direction (Barlow and Levick, 1965). We now know this computation relies on the coordination of three transmitter systems: glutamate, GABA and acetylcholine (ACh). In this talk, I will discuss the synaptic mechanisms that produce the spatiotemporal patterns of inhibition and excitation that are crucial for shaping directional selectivity. Special emphasis will be placed on the role of ACh, as it is unclear whether it is mediated by synaptic or non-synaptic mechanisms, which is in fact a central issue in the CNS.\nBarlow, H.B., and Levick, W.R. (1965). The mechanism of directionally selective units in rabbit's retina. J Physiol 178, 477-504.\nMauss, A.S., Vlasits, A., Borst, A., and Feller, M. (2017). Visual Circuits for Direction Selectivity. Annu Rev Neurosci 40, 211-230.\nVaney, D.I., Sivyer, B., and Taylor, W.R. (2012). Direction selectivity in the retina: symmetry and asymmetry in structure and function. Nat Rev Neurosci 13, 194-208", "hosted_by": "Sussex Visions", "domain": ["Neuroscience"], "calendar_event_hash": "e027d8b26f7b18639f953df0bfd9947013f95e3a0ad105fb837ffaa2c83a53f2", "seminar_id": 873, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "874": {"seminar_date": "Mon, May 18, 2020", "seminar_time": "14:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://www.youtube.com/watch?v=mlE6KXUWq3o&list=PLxQjmU-K7_E7gZsrsGHh_4nC_05KXDIX8&index=5&t=0s", "password": "", "video_on_demand": "https://www.youtube.com/watch?v=mlE6KXUWq3o&list=PLxQjmU-K7_E7gZsrsGHh_4nC_05KXDIX8&index=5&t=0s", "speaker_title": "Prof", "seminar_speaker": "Marion Silies", "speaker_affil": "Johannes Gutenberg-Universit\u00e4t Mainz, Germany", "speaker_twitter": "", "speaker_website": "https://ncl-idn.biologie.uni-mainz.de/", "topic_tags": "retina, drosophila, vision, two-photon imaging, invertebrate, systems, electrophsyiology", "seminar_title": "Vision in dynamically changing environments", "seminar_abstract": "Many visual systems can process information in dynamically changing environments. In general, visual perception scales with changes in the visual stimulus, or contrast, irrespective of background illumination. This is achieved by adaptation. However, visual perception is challenged when adaptation is not fast enough to deal with sudden changes in overall illumination, for example when gaze follows a moving object from bright sunlight into a shaded area. We have recently shown that the visual system of the fly found a solution by propagating a corrective luminance-sensitive signal to higher processing stages. Using in vivo two-photon imaging and behavioural analyses we showed that distinct OFF-pathway inputs encode contrast and luminance. The luminance-sensitive pathway is particularly required when processing visual motion in contextual dim light, when pure contrast sensitivity underestimates the salience of a stimulus. \nRecent work in the lab has addressed the question how two visual pathways obtain such fundamentally different sensitivities, given common photoreceptor input. We are furthermore currently working out the network-based strategies by which luminance- and contrast-sensitive signals are combined to guide appropriate visual behaviour. Together, I will discuss the molecular, cellular, and circuit mechanisms that ensure contrast computation, and therefore robust vision, in fast changing visual scenes.", "hosted_by": "Sussex Visions", "domain": ["Neuroscience"], "calendar_event_hash": "4b1917131066152e136f9a6f17edf71b364ed76ebc10bfb026efd9792b108cdd", "seminar_id": 874, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "875": {"seminar_date": "Wed, May 20, 2020", "seminar_time": "14:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://www.youtube.com/watch?v=GPe4zN1YxH8&list=PLxQjmU-K7_E7gZsrsGHh_4nC_05KXDIX8&index=4&t=0s", "password": "", "video_on_demand": "https://www.youtube.com/watch?v=GPe4zN1YxH8&list=PLxQjmU-K7_E7gZsrsGHh_4nC_05KXDIX8&index=4&t=0s", "speaker_title": "Prof", "seminar_speaker": "Tim Gollisch", "speaker_affil": "University of Goettingen", "speaker_twitter": "@TimGollisch", "speaker_website": "https://www.retina.uni-goettingen.de/", "topic_tags": "retina, vision, systems, electrophysiology", "seminar_title": "Natural stimulus encoding in the retina with linear and nonlinear receptive fields", "seminar_abstract": "Popular notions of how the retina encodes visual stimuli typically focus on the center-surround receptive fields of retinal ganglion cells, the output neurons of the retina. In this view, the receptive field acts as a linear filter on the visual stimulus, highlighting spatial contrast and providing efficient representations of natural images. Yet, we also know that many ganglion cells respond vigorously to fine spatial gratings that should not activate the linear filter of the receptive field. Thus, ganglion cells may integrate visual signals nonlinearly across space. In this talk, I will discuss how these (and other) nonlinearities relate to the encoding of natural visual stimuli in the retina. Based on electrophysiological recordings of ganglion and bipolar cells from mouse and salamander retina, I will present methods for assessing nonlinear processing in different cell types and examine their importance and potential function under natural stimulation.", "hosted_by": "Sussex Visions", "domain": ["Neuroscience"], "calendar_event_hash": "daa50ccbc9521f219784a16ff13dbdf885e22b324c00c1ae35e18d0b3c3d54ca", "seminar_id": 875, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "876": {"seminar_date": "Tue, Jun 16, 2020", "seminar_time": "14:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://www.youtube.com/watch?v=BrM0iSN4b-8&list=PLxQjmU-K7_E7gZsrsGHh_4nC_05KXDIX8&index=7", "password": "", "video_on_demand": "https://www.youtube.com/watch?v=BrM0iSN4b-8&t=4003s", "speaker_title": "Dr", "seminar_speaker": "Peter Neri", "speaker_affil": "\u00c9cole Normale Sup\u00e9rieure", "speaker_twitter": "", "speaker_website": "", "topic_tags": "natural scenes, theory, vision, retina", "seminar_title": "Human reconstruction of local image structure from natural scenes", "seminar_abstract": "Retinal projections often poorly represent the structure of the physical world: well-defined boundaries within the eye may correspond to irrelevant features of the physical world, while critical features of the physical world may be nearly invisible at the retinal projection. Visual cortex is equipped with specialized mechanisms for sorting these two types of features according to their utility in interpreting the scene, however we know little or nothing about their perceptual computations. I will present novel paradigms for the characterization of these processes in human vision, alongside examples of how the associated empirical results can be combined with targeted models to shape our understanding of the underlying perceptual mechanisms. Although the emerging view is far from complete, it challenges compartmentalized notions of bottom-up/top-down object segmentation, and suggests instead that these two modes are best viewed as an integrated perceptual mechanism.", "hosted_by": "Sussex Visions", "domain": ["Neuroscience"], "calendar_event_hash": "363de02bde73793b63c3a151c9ed440c57e6f35eac1c292edc1b961d2b3c42e1", "seminar_id": 876, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "877": {"seminar_date": "Wed, Jun 17, 2020", "seminar_time": "17:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://www.youtube.com/watch?v=Myvh1l0G90g&list=PLxQjmU-K7_E7gZsrsGHh_4nC_05KXDIX8&index=8", "password": "", "video_on_demand": "https://www.youtube.com/watch?v=Myvh1l0G90g&list=PLxQjmU-K7_E7gZsrsGHh_4nC_05KXDIX8&index=8", "speaker_title": "Prof", "seminar_speaker": "E.J. Chichilnisky", "speaker_affil": "Stanford University", "speaker_twitter": "", "speaker_website": "http://med.stanford.edu/chichilnisky.html", "topic_tags": "retina, artificial vision, electrophysiology, natural scenes, systems", "seminar_title": "Toward a High-fidelity Artificial Retina for Vision Restoration", "seminar_abstract": "Electronic interfaces to the retina represent an exciting development in science, engineering, and medicine \u2013 an opportunity to exploit our knowledge of neural circuitry and function to restore or even enhance vision. However, although existing devices demonstrate proof of principle in treating incurable blindness, they produce limited visual function. Some of the reasons for this can be understood based on the precise and specific neural circuitry that mediates visual signaling in the retina. Consideration of this circuitry suggests that future devices may need to operate at single-cell, single-spike resolution in order to mediate naturalistic visual function. I will show large-scale multi-electrode recording and stimulation data from the primate retina indicating that, in some cases, such resolution is possible. I will also discuss cases in which it fails, and propose that we can improve artificial vision in such conditions by incorporating our knowledge of the visual system in bi-directional devices that adapt to the host neural circuitry. Finally, I will introduce the Stanford\nArtificial Retina Project, aimed at developing a retinal implant that more faithfully reproduces the neural code of the retina, and briefly discuss the implications for scientific investigation and for other neural interfaces of the future.", "hosted_by": "Sussex Visions", "domain": ["Neuroscience"], "calendar_event_hash": "113b5776eec4c50ad3b2d8b802e6da1ea3065add827b0c31a46c150a10e2b4ba", "seminar_id": 877, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "878": {"seminar_date": "Tue, Jul 7, 2020", "seminar_time": "15:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://youtu.be/UhKGTOq13EY", "password": "", "video_on_demand": "https://youtu.be/UhKGTOq13EY", "speaker_title": "Dr", "seminar_speaker": "Katrin Franke", "speaker_affil": "University of Tubingen", "speaker_twitter": "@kfrankelab", "speaker_website": "https://www.cin.uni-tuebingen.de/research/research-groups/research-groups/franke-k-neural-circuits-of-vision/research-directions.html", "topic_tags": "natural scenes, retina, vision, systems, two-photon imaging, electrophysiology", "seminar_title": "What the eye tells the brain: Visual feature extraction in the mouse retina", "seminar_abstract": "Visual processing begins in the retina: within only two synaptic layers, multiple parallel feature channels emerge, which relay highly processed visual information to different parts of the brain. To functionally characterize these feature channels we perform calcium and glutamate population activity recordings at different levels of the mouse retina. This allows following the complete visual signal across consecutive processing stages in a systematic way.\nIn my talk, I will summarize our recent findings on the functional diversity of retinal output channels and how they arise within the retinal network. Specifically, I will talk about the role of inhibition and cell-type specific dendritic processing in generating diverse visual channels. Then, I will focus on how color \u2013 a single visual feature \u2013 emerges across all retinal processing layers and link our results to behavioral output and the statistics of mouse natural scenes. With our approach, we hope to identify general computational principles of retinal signaling, thereby increasing our understanding of what the eye tells the brain.", "hosted_by": "Sussex Visions", "domain": ["Neuroscience"], "calendar_event_hash": "654141abb4bb8a1da168f5092eaa90255be37f79036c9435b6ae8ae73f541170", "seminar_id": 878, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "347": {"seminar_date": "Fri, Jul 10, 2020", "seminar_time": "16:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://www.youtube.com/watch?v=FkaFhzMZJ4w", "password": "", "video_on_demand": "https://www.youtube.com/watch?v=FkaFhzMZJ4w", "speaker_title": "Prof", "seminar_speaker": "Tod Thiele and Dr. Emily Cooper", "speaker_affil": "Tod Thiele: University of Toronto Scarborough; Emily Cooper: University of California, Berkeley", "speaker_twitter": "@TodThiele", "speaker_website": "https://thielelab.ca/   http://www.emilyacooper.org/", "topic_tags": "vision, zebrafish, systems", "seminar_title": "Understanding the visual demands of underwater habitats for aquatic animals used in neuroscience research", "seminar_abstract": "Zebrafish and cichlids are popular models in visual neuroscience, due to their amenability to advanced research tools and their diverse set of visually guided behaviours. It is often asserted that animals\u2019 neural systems are adapted to the statistical regularities in their natural environments, but relatively little is known about the visual spatiotemporal features in the underwater habitats that nurtured these fish. To address this gap, we have embarked on an examination of underwater habitats in northeastern India and Lake Tanganyika (Zambia), where zebrafish and cichlids are native. In this talk, we will describe the methods used to conduct a series of field measurements and generate a large and diverse dataset of these underwater habitats. We will present preliminary results suggesting that the demands for visually-guided navigation differ between these underwater habitats and the terrestrial habitats characteristic of other model species.", "hosted_by": "Sussex Visions", "domain": ["Neuroscience"], "calendar_event_hash": "2a18c4130163b3a1e0729a122da09f1b397803069211fabd8d7b3ec9afc42ebf", "seminar_id": 347, "time_of_addition": "Wed, Jul 08, 2020 00:14"}, "879": {"seminar_date": "Fri, Jul 17, 2020", "seminar_time": "17:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://www.youtube.com/watch?v=F_njzRKJLUQ&list=PLxQjmU-K7_E7gZsrsGHh_4nC_05KXDIX8&index=2", "password": "", "video_on_demand": "https://www.youtube.com/watch?v=F_njzRKJLUQ&list=PLxQjmU-K7_E7gZsrsGHh_4nC_05KXDIX8&index=2", "speaker_title": "Prof", "seminar_speaker": "Thomas Euler", "speaker_affil": "University of Tubingen", "speaker_twitter": "@teulerlab", "speaker_website": "https://eulerlab.de/", "topic_tags": "vision, retina, mouse", "seminar_title": "Natural visual stimuli for mice", "seminar_abstract": "During the course of evolution, a species\u2019 environment shapes its sensory abilities, as individuals with more optimized sensory abilities are more likely survive and procreate. Adaptations to the statistics of the natural environment can be observed along the early visual pathway and across species. Therefore, characterising the properties of natural environments and studying the representation of natural scenes along the visual pathway is crucial for advancing our understanding of the structure and function of the visual system. In the past 20 years, mice have become an important model in vision research, but the fact that they live in a different environment than primates and have different visual needs is rarely considered. One particular challenge for characterising the mouse\u2019s visual environment is that they are dichromats with photoreceptors that detect UV light, which the typical camera does not record. This also has consequences for experimental visual stimulation, as the blue channel of computer screens fails to excite mouse UV cone photoreceptors. In my talk, I will describe our approach to recording \u201ccolour\u201d footage of the habitat of mice \u2013 from the mouse\u2019s perspective \u2013 and to studying retinal circuits in the ex vivo retina with natural movies.", "hosted_by": "Sussex Visions", "domain": ["Neuroscience"], "calendar_event_hash": "92f2fc727edfbfc5439ea4780cc48d9333daee808970ab46ab36904a57f9ef0a", "seminar_id": 879, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "590": {"seminar_date": "Wed, Sep 16, 2020", "seminar_time": "14:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://youtu.be/EwKmCkuZQVs", "password": "", "video_on_demand": "https://youtu.be/EwKmCkuZQVs", "speaker_title": "Prof", "seminar_speaker": "Leon Lagnado", "speaker_affil": "University of Sussex", "speaker_twitter": "@neonsynapse", "speaker_website": "https://lagnadolab.com/", "topic_tags": "vision, retina, zebrafish", "seminar_title": "Dynamic computation in the retina by retuning of neurons and synapses", "seminar_abstract": "", "hosted_by": "Sussex Visions", "domain": ["Neuroscience"], "calendar_event_hash": "a1583bf5b868608db5d606b1a3a17ead1f674e451b0db04fb616486472ee9dee", "seminar_id": 590, "time_of_addition": "Mon, Sep 07, 2020 12:15"}, "693": {"seminar_date": "Mon, Sep 28, 2020", "seminar_time": "15:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://youtu.be/ygUlM7sp4Oc", "password": "", "video_on_demand": "https://youtu.be/ygUlM7sp4Oc", "speaker_title": "Dr", "seminar_speaker": "Aristides Arrenberg", "speaker_affil": "University of Tuebingen", "speaker_twitter": "@Arrenberglab", "speaker_website": "https://arrenberg-lab.de/team/", "topic_tags": "vision, retina, zebrafish", "seminar_title": "Motion processing across visual field locations in zebrafish", "seminar_abstract": "", "hosted_by": "Sussex Visions", "domain": ["Neuroscience"], "calendar_event_hash": "dfe2f26f64f284c69faebb0c1255af6c187e3e69cffa1008e91ed6aa024b7b48", "seminar_id": 693, "time_of_addition": "Sat, Sep 19, 2020 17:40"}, "721": {"seminar_date": "Mon, Oct 12, 2020", "seminar_time": "15:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://youtu.be/9W7K5FRhj2E", "password": "", "video_on_demand": "https://youtu.be/9W7K5FRhj2E", "speaker_title": "Dr", "seminar_speaker": "Evelyne Sernagor", "speaker_affil": "Newcastle University", "speaker_twitter": "", "speaker_website": "https://www.ncl.ac.uk/medical-sciences/people/profile/evelynesernagor.html", "topic_tags": "vision, retina", "seminar_title": "", "seminar_abstract": "", "hosted_by": "Sussex Visions", "domain": ["Neuroscience"], "calendar_event_hash": "2ee8088d577d3e31a8dba90699dee5569acdda8a592b3227972f5869eadcfe85", "seminar_id": 721, "time_of_addition": "Mon, Sep 21, 2020 17:40"}, "797": {"seminar_date": "Tue, Jun 23, 2020", "seminar_time": "16:00", "timezone": "Europe/London", "posted": "Yes", "seminar_link": "https://ucl.zoom.us/webinar/register/1215902570684/WN_SGrGjeWORuSb02b2a6ukow", "password": "", "video_on_demand": "https://www.youtube.com/watch?v=Cb8A8TqwjY8&t=121s", "speaker_title": "Prof", "seminar_speaker": "John Hardy", "speaker_affil": "University College London", "speaker_twitter": "@IPDGC_Africa", "speaker_website": "https://www.ucl.ac.uk/uk-dementia-research-institute/john-hardy", "topic_tags": "", "seminar_title": "The Genetics of Parkinson's Disease: Understanding the Differences Between European and African Populations", "seminar_abstract": "In this talk, Professor Hardy will discuss the different causes and predispositions of PD that exist in Africa, and the differences to European populations. He will go on to discuss the importance of highlighting these differences and the impact of this vital research to people living with PD in Africa, as well as their families and caregivers.", "hosted_by": "IPDGC Africa", "domain": ["Neuroscience"], "calendar_event_hash": "645fdc98a0b3726423374bc6e3e444df3ab3f0539c04b5350e6c06c6b77a4f1e", "seminar_id": 797, "time_of_addition": "Mon, Sep 28, 2020 11:06"}, "329": {"seminar_date": "Tue, Jul 28, 2020", "seminar_time": "16:00", "timezone": "Europe/London", "posted": "Yes", "seminar_link": "https://ucl.zoom.us/webinar/register/9715935985110/WN_FjMUOp1KRHuj98UOWYGj5Q", "password": "", "video_on_demand": "", "speaker_title": "Dr", "seminar_speaker": "Andrew Singleton", "speaker_affil": "National Institute on Aging", "speaker_twitter": "@IPDGC_Africa", "speaker_website": "https://irp.nih.gov/pi/andrew-singleton", "topic_tags": "genetics, Parkinson's Disease", "seminar_title": "Exploring the Genetics of Parkinson's Disease: Past, Present, and Future", "seminar_abstract": "In this talk, Dr Singleton will discuss the progress made so far in understanding the genetic basis of Parkinson\u2019s disease. He will cover the history of discovery from the first identification of disease causing mutations to the state of knowledge in the field today, more that 20 years after that initial discovery. He will then discuss current initiatives and the promise of these for informing the understanding and treatment of Parkinson\u2019s disease. 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It is essential that the risk factors be carefully delineated for the formulation of preventive strategies. Epigenetics refers to external modifications that turn genes \"on\" or \"off\u201d, and cross-cultural studies of migrant populations provide information on the interplay of environmental factors on genetic predisposition. The Indianapolis-Ibadan Dementia Study compared the prevalence, incidence and risk factors of dementia in African Americans and Yoruba to tease out the role of epigenetics in dementia. The presentation will provide details on biomarkers of dementia, vascular risk factors and the association with apolipoprotein E in the Yoruba. 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"seminar_title": "Problem-solving in acellular slime molds", "seminar_abstract": "", "hosted_by": "NeuroBehaviour in Quarantine Times", "domain": ["Neuroscience"], "calendar_event_hash": "5e9dd4e939cfc7aa0db3bbcbc481483b09e790df8d4c2cca6d8ada218a5f8e1d", "seminar_id": 861, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "659": {"seminar_date": "Wed, Sep 23, 2020", "seminar_time": "12:15", "timezone": "America/New_York", "posted": "yes", "seminar_link": "https://bostonu.zoom.us/j/99286135804?pwd=VkZQakw1ZWxJYlZNLzRCTlRwYXd1UT09", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Kate Wassum", "speaker_affil": "University of California, Los Angeles", "speaker_twitter": "@KateWassum", "speaker_website": "https://wassumlab.psych.ucla.edu/people/kate-wassum-ph-d/", "topic_tags": "", "seminar_title": "Corticolimbic Circuitry in Reward Learning and Pursuit", "seminar_abstract": "", "hosted_by": "Boston Sys Neuro", "domain": ["Neuroscience"], "calendar_event_hash": "3eebdf3712ddcd605c25e03036c8c1df40e3a3152dccb20a285fa104a854b761", "seminar_id": 659, "time_of_addition": "Tue, Sep 15, 2020 13:30"}, "1156": {"seminar_date": "Wed, Oct 21, 2020", "seminar_time": "12:15", "timezone": "America/New_York", "posted": "yes", "seminar_link": "https://bostonu.zoom.us/j/94475887937?pwd=RGx1em1pWmZLVmJqMnZaZy9VTnRxUT09", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Chethan Pandarinath", "speaker_affil": "Emory University, Department of Biomedical Engeering", "speaker_twitter": "@chethan", "speaker_website": "https://snel.gatech.edu/", "topic_tags": "", "seminar_title": "Towards generalized inference of single-trial neural population dynamics", "seminar_abstract": "", "hosted_by": "Boston Sys Neuro", "domain": ["Neuroscience"], "calendar_event_hash": "75aa359009dd292070b291a005e20a6c0e99569693be7f4c981e809d59a56fa9", "seminar_id": 1156, "time_of_addition": "Mon, Oct 05, 2020 16:50"}, "800": {"seminar_date": "Wed, May 20, 2020", "seminar_time": "17:30", "timezone": "Africa/Cairo", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/nervevent-mariekevanvugt/register", "password": "", "video_on_demand": "https://www.crowdcast.io/e/nervevent-mariekevanvugt/register", "speaker_title": "Prof", "seminar_speaker": "Marieke van Vugt", "speaker_affil": "University of Groningen", "speaker_twitter": "@mvugt", "speaker_website": "http://www.ai.rug.nl/~mkvanvugt", "topic_tags": "psychology, ML, imaging", "seminar_title": "Using computational modeling of cognition and machine learning to understand the elusive process of mind-wandering", "seminar_abstract": "", "hosted_by": "NERV", "domain": ["Neuroscience"], "calendar_event_hash": "312bcd6bf9057108887db287779e14bfb8e347b4c67651b571d694361e15e027", "seminar_id": 800, "time_of_addition": "Mon, Sep 28, 2020 11:06"}, "801": {"seminar_date": "Wed, Jun 3, 2020", "seminar_time": "17:30", "timezone": "Africa/Johannesburg", "posted": "Yes", "seminar_link": "https://www.crowdcast.io/e/nervevent-betonyadams/register", "password": "", "video_on_demand": "https://www.crowdcast.io/e/nervevent-betonyadams/register", "speaker_title": "", "seminar_speaker": "Betony Adams", "speaker_affil": "University of KwaZulu Natal, South Africa", "speaker_twitter": "", "speaker_website": "https://quantum.ukzn.ac.za/", "topic_tags": "quantum physics", "seminar_title": "Quantum effects in the brain - a viable assumption?", "seminar_abstract": "", "hosted_by": "NERV", "domain": ["Neuroscience"], "calendar_event_hash": "7bb6e34f8bac516815b7d521d5b43b89506c8c20cc5b667a0f1a577b96d9faac", "seminar_id": 801, "time_of_addition": "Mon, Sep 28, 2020 11:06"}, "802": {"seminar_date": "Wed, Jul 1, 2020", "seminar_time": "17:30", "timezone": "Africa/Johannesburg", "posted": "Yes", "seminar_link": "https://www.crowdcast.io/e/nervevent-terrystewart/register", "password": "", "video_on_demand": "https://www.crowdcast.io/e/nervevent-terrystewart/register", "speaker_title": "Dr", "seminar_speaker": "Terry Stewart", "speaker_affil": "National Research Council of Canada and University of Waterloo Collaboration Centre", "speaker_twitter": "", "speaker_website": "http://terrystewart.ca", "topic_tags": "neural engineering, neuromorphics, cognitive architecture", "seminar_title": "Neural Engineering: Building large-scale cognitive models of the brain", "seminar_abstract": "The Neural Engineering Framework has been used to create a wide variety of biologically realistic brain simulations that are capable of performing simple cognitive tasks (remembering a list, counting, etc.). This includes the largest existing functional brain model. This talk will describe this method, and show some examples of using it to take high-level cognitive algorithms and convert them into a neural network that implements those algorithms. Overall, this approach gives us new ways of thinking about how the brain works and what sorts of algorithms it is capable of performing.", "hosted_by": "NERV", "domain": ["Neuroscience"], "calendar_event_hash": "1f955c00c8b02595234733470df3e6d2335178521bf874456f3c186072572ffd", "seminar_id": 802, "time_of_addition": "Mon, Sep 28, 2020 11:06"}, "803": {"seminar_date": "Wed, Jul 29, 2020", "seminar_time": "17:30", "timezone": "Africa/Johannesburg", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/nervevent-marksolms/register", "password": "", "video_on_demand": "https://www.crowdcast.io/e/nervevent-marksolms/register", "speaker_title": "Prof", "seminar_speaker": "Mark Solms", "speaker_affil": "Neuroscience Institute, University of Cape Town", "speaker_twitter": "", "speaker_website": "", "topic_tags": "consciousness, homeostasis, self-organisation, free energy principle", "seminar_title": "A New Approach to the Hard Problem of Consciousness", "seminar_abstract": "David Chalmers\u2019s (1995) hard problem famously states: \u201cIt is widely agreed that experience arises from a physical basis, but we have no good explanation of why and how it so arises.\u201d Thomas Nagel (1974) wrote something similar: \u201cIf we acknowledge that a physical theory of mind must account for the subjective character of experience, we must admit that no presently available conception gives us a clue about how this could be done.\u201d This presentation will point the way towards the long-sought \u201cgood explanation\u201d -- or at least it will provide \u201ca clue\u201d. I will make three points: (1) It is unfortunate that cognitive science took vision as its model example when looking for a \u2018neural correlate of consciousness\u2019 because cortical vision (like most cognitive processes) is not intrinsically conscious. There is not necessarily \u2018something it is like\u2019 to see. (2) Affective feeling, by contrast, is conscious by definition. You cannot feel something without feeling it. Moreover, affective feeling, generated in the upper brainstem, is the foundational form of consciousness: prerequisite for all the higher cognitive forms. (3) The functional mechanism of feeling explains why and how it cannot go on \u2018in the dark\u2019, free of any inner feel. Affect enables the organism to monitor deviations from its expected self-states in uncertain situations and thereby frees homeostasis from the limitations of automatism. As Nagel says, \u201cAn organism has conscious mental states if and only if there is something that it is like to be that organism\u2014something it is like for the organism.\u201d Affect literally constitutes the sentient subject.", "hosted_by": "NERV", "domain": ["Neuroscience"], "calendar_event_hash": "de10fbda7b4807e977d3a7d30cd04a519624d2f5476f35fd1841f5ca4cd2fdc1", "seminar_id": 803, "time_of_addition": "Mon, Sep 28, 2020 11:06"}, "417": {"seminar_date": "Wed, Aug 12, 2020", "seminar_time": "17:30", "timezone": "Africa/Johannesburg", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/nervevent-graceleslie/register", "password": "", "video_on_demand": "https://www.crowdcast.io/e/nervevent-graceleslie/register", "speaker_title": "Dr", "seminar_speaker": "Grace Leslie", "speaker_affil": "Georgia Institute of Technology", "speaker_twitter": "@gracealeslie", "speaker_website": "http://www.graceleslie.com", "topic_tags": "music, brain-computer interface", "seminar_title": "Brain-Body Music Interfaces for Creativity, Education and Well-being", "seminar_abstract": "The Georgia Tech Brain Music Lab is a community gathered around a unique facility combining EEG and other physiological measurement techniques with new music technologies. Their mission is to engage in research and creative practice that brings health and well-being. This talk will present an overview of the activities at the Brain Music Lab, including sonification of physiological signals, acoustic design for health and well-being, therapeutic applications of musical stimulation, and brain-body music performance.", "hosted_by": "NERV", "domain": ["Neuroscience"], "calendar_event_hash": "e8897f26298d229a9fee5c547ea069f560ea8c1a8c7f05bb16ddf7718ce85d7b", "seminar_id": 417, "time_of_addition": "Wed, Aug 05, 2020 12:05"}, "486": {"seminar_date": "Wed, Aug 26, 2020", "seminar_time": "17:30", "timezone": "Africa/Johannesburg", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/nervevent-aimeedollman/register", "password": "", "video_on_demand": "https://www.crowdcast.io/e/nervevent-aimeedollman/register", "speaker_title": "", "seminar_speaker": "Aimee Dollman", "speaker_affil": "University of Cape Town", "speaker_twitter": "", "speaker_website": "", "topic_tags": "visuospatial cognition, mirror reversal, orientation, visual systems, predictive coding", "seminar_title": "A Rare Visuospatial Disorder", "seminar_abstract": "Cases with visuospatial abnormalities provide opportunities for understanding the underlying cognitive mechanisms. Three cases of visual mirror-reversal have been reported: AH (McCloskey, 2009), TM (McCloskey, Valtonen, & Sherman, 2006) and PR (Pflugshaupt et al., 2007). This research reports a fourth case, BS -- with focal occipital cortical dysgenesis -- who displays highly unusual visuospatial abnormalities. They initially produced mirror reversal errors similar to those of AH, who -- like the patient in question -- showed a selective developmental deficit. Extensive examination of BS revealed phenomena such as: mirror reversal errors (sometimes affecting only parts of the visual fields) in both horizontal and vertical planes; subjective representation of visual objects and words in distinct left and right visual fields; subjective duplication of objects of visual attention (not due to diplopia); uncertainty regarding the canonical upright orientation of everyday objects; mirror reversals during saccadic eye movements on oculomotor tasks; and failure to integrate visual with other sensory inputs (e.g., they feel themself moving backwards when visual information shows they are moving forward). Fewer errors are produced under conditions of certain visual variables. These and other findings have led the researchers to conclude that BS draws upon a subjective representation of visual space that is structured phenomenally much as it is anatomically in early visual cortex (i.e., rotated through 180 degrees, split into left and right fields, etc.). Despite this, BS functions remarkably well in their everyday life, apparently due to extensive compensatory mechanisms deployed at higher (executive) processing levels beyond the visual modality.", "hosted_by": "NERV", "domain": ["Neuroscience"], "calendar_event_hash": "1ddbaabb85343c10bf9fe5c2547f0de10f8bc1a772992fc1f77f7be140b77723", "seminar_id": 486, "time_of_addition": "Mon, Aug 17, 2020 13:23"}, "567": {"seminar_date": "Wed, Sep 9, 2020", "seminar_time": "17:30", "timezone": "Africa/Johannesburg", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/nervevent-siobhanhall", "password": "", "video_on_demand": "https://www.crowdcast.io/e/nervevent-siobhanhall", "speaker_title": "", "seminar_speaker": "Siobhan Hall", "speaker_affil": "Stellenbosch University", "speaker_twitter": "@smhall94", "speaker_website": "https://www.linkedin.com/in/siobhan-hall-805255bb/", "topic_tags": "free will, decision-making, machine learning", "seminar_title": "Free will, decision-making and machine learning", "seminar_abstract": "The question of free will has been topical for millennia, especially considering its links to moral responsibility and the ownership of that responsibility. Free will, or volition, is an incredibly complex phenomenon - and cannot easily be reduced to a single empirical paradigm. Roskies (2010) proposes that there are five cognitive aspects to be considered when developing a more complete understanding of volition. These are: intention, initiation, feeling, executive control and decision-making. Decision-making will be the focus of this talk, which steps through aspects of the philosophy of free will; highlights experimental paradigms stemming from the seminal work of Benjamin Libet et al., and proposes machine learning as a promising method in progressing the empirical studies of decision-making and free will.", "hosted_by": "NERV", "domain": ["Neuroscience"], "calendar_event_hash": "d23515bd88034c41633ef923f3a445d91fea5a62a9e454b9d5dbfd61ab007e4b", "seminar_id": 567, "time_of_addition": "Tue, Sep 01, 2020 18:50"}, "639": {"seminar_date": "Wed, May 6, 2020", "seminar_time": "17:30", "timezone": "Africa/Johannesburg", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/nervevent-pedro/register", "password": "", "video_on_demand": "https://www.crowdcast.io/e/nervevent-pedro/register", "speaker_title": "", "seminar_speaker": "Pedro Herrero-Vidal", "speaker_affil": "New York University", "speaker_twitter": "@PedroHerreroV", "speaker_website": "https://pedroherrerovidal.github.io/", "topic_tags": "decoding, olfactory system", "seminar_title": "Decoding of Chemical Information from Populations of Olfactory Neurons", "seminar_abstract": "Information is represented in the brain by the coordinated activity of populations of neurons. Recent large-scale neural recording methods in combination with machine learning algorithms are helping understand how sensory processing and cognition emerge from neural population activity. This talk will explore the most popular machine learning methods used to gather meaningful low-dimensional representations from higher-dimensional neural recordings. To illustrate the potential of these approaches, Pedro will present his research in which chemical information is decoded from the olfactory system of the mouse for technological applications. Pedro and co-researchers have successfully extracted odor identity and concentration from olfactory receptor neuron low-dimensional activity trajectories. They have further developed a novel method to identify a shared latent space that allowed decoding of odor information across animals.", "hosted_by": "NERV", "domain": ["Neuroscience"], "calendar_event_hash": "22b9e6adecd2144ad160ea730b052e2018b903bc53f7c805762c3a06723d0ead", "seminar_id": 639, "time_of_addition": "Thu, Sep 10, 2020 17:55"}, "643": {"seminar_date": "Wed, Sep 23, 2020", "seminar_time": "17:30", "timezone": "Africa/Johannesburg", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/nervevent-pelonomimoiloa", "password": "", "video_on_demand": "https://www.crowdcast.io/e/nervevent-pelonomimoiloa", "speaker_title": "", "seminar_speaker": "Pelonomi Moila", "speaker_affil": "Nedbank", "speaker_twitter": "@tamati_biskit", "speaker_website": "", "topic_tags": "ml fairness, power dynamics, algorithmic bias", "seminar_title": "Protecting Machines from Us", "seminar_abstract": "The possibilities of machine learning and neural networks in particular are ever expanding. With increased opportunities to do good, however there are just as many opportunities to do harm and even in the case that good intentions are at the helm, evidence suggests that opportunities for good may eventually prove to be the opposite. The greatest threat to what machine learning is able to achieve and to us as humans, is machine learning that does not reflect the diversity of the users it is meant to serve. It is important that we are not so pre-occupied with advancing technology into the future that we have not taken the time to invest the energy into engineering the security measures this future requires. It is important to investigate now, as thoroughly as we investigate differing deep neural network architectures, the complex questions regarding the fact that humans and the society in which they operate is inherently biased and loaded with prejudice and that these traits find themselves in the machines we create (and increasingly allow to run our lives).", "hosted_by": "NERV", "domain": ["Neuroscience"], "calendar_event_hash": "23bbd03d741e084c35d9e9f42b3be277020b46c89385f49ff11f5f6eb7d96e3b", "seminar_id": 643, "time_of_addition": "Fri, Sep 11, 2020 17:10"}, "1073": {"seminar_date": "Wed, Oct 7, 2020", "seminar_time": "17:30", "timezone": "Africa/Johannesburg", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/nervevent-michellejohnson", "password": "", "video_on_demand": "https://www.crowdcast.io/e/nervevent-michellejohnson", "speaker_title": "Dr", "seminar_speaker": "Michelle Johnson", "speaker_affil": "University of Pennsylvania, Department of Physical Medicine and Rehabilitation and Department of BioEngineering", "speaker_twitter": "@RehabRobot", "speaker_website": "https://www.med.upenn.edu/rehabilitation-robotics-lab/", "topic_tags": "robotics, neurorehabilitation, Non-Traumatic Brain Injury", "seminar_title": "Affordable Robots/Computer Systems to Identify, Assess, and Treat Impairment After Brain Injury", "seminar_abstract": "Non-traumatic brain injury due to stroke, cerebral palsy and HIV often result in serious long-term disability worldwide, affecting more than 150 million persons globally; with the majority of persons living in low and middle income countries. These diseases often result in varying levels of motor and cognitive impairment due to brain injury which then affects the person\u2019s ability to complete activities of daily living and fully participate in society. Increasingly advanced technologies are being used to support identification, diagnosis, assessment, and therapy for patients with brain injury. Specifically, robot and mechatronic systems can provide patients, physicians and rehabilitation clinical providers with additional support to care for and improve the quality of life of children and adults with motor and cognitive impairment. This talk will provide a brief introduction to the area of rehabilitation robotics and, via case studies, illustrate how computer/technology-assisted rehabilitation systems can be developed and used to assess motor and cognitive impairment, detect early evidence of functional impairment, and augment therapy in high and low-resource settings.", "hosted_by": "NERV", "domain": ["Neuroscience"], "calendar_event_hash": "08a9aedcb4815c7b0ce36c0cc3f90c685e88778e97bcf714998e6f825a98201e", "seminar_id": 1073, "time_of_addition": "Sun, Oct 04, 2020 17:05"}, "808": {"seminar_date": "Mon, Jun 8, 2020", "seminar_time": "10:00", "timezone": "Asia/Jerusalem", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/dr--tilo-schwalger", "password": "", "video_on_demand": "https://youtu.be/bmlvx9A1C1c", "speaker_title": "Dr.", "seminar_speaker": "Tilo Schwalger", "speaker_affil": "TU Berlin", "speaker_twitter": "", "speaker_website": "http://page.math.tu-berlin.de/~schwalge/", "topic_tags": "theory, math", "seminar_title": "Mean-field models for finite-size populations of spiking neurons", "seminar_abstract": "Firing-rate (FR) or neural-mass models are widely used for studying computations performed by neural populations. Despite their success, classical firing-rate models do not capture spike timing effects on the microscopic level such as spike synchronization and are difficult to link to spiking data in experimental recordings. For large neuronal populations, the gap between the spiking neuron dynamics on the microscopic level and coarse-grained FR models on the population level can be bridged by mean-field theory formally valid for infinitely many neurons. It remains however challenging to extend the resulting mean-field models to finite-size populations with biologically realistic neuron numbers per cell type (mesoscopic scale). In this talk, I present a mathematical framework for mesoscopic populations of generalized integrate-and-fire neuron models that accounts for fluctuations caused by the finite number of neurons. To this end, I will introduce the refractory density method for quasi-renewal processes and show how this method can be generalized to finite-size populations. To demonstrate the flexibility of this approach, I will show how synaptic short-term plasticity can be incorporated in the mesoscopic mean-field framework. On the other hand, the framework permits a systematic reduction to low-dimensional FR equations using the eigenfunction method. Our modeling framework enables a re-examination of classical FR models in computational neuroscience under biophysically more realistic conditions.", "hosted_by": "NeuroMath", "domain": ["Neuroscience"], "calendar_event_hash": "e3dc4880913c2ace50a10ee253876663dc7cd1a8fdb5a7d841e8134f3944807e", "seminar_id": 808, "time_of_addition": "Mon, Sep 28, 2020 11:06"}, "809": {"seminar_date": "Thu, Jun 25, 2020", "seminar_time": "16:00", "timezone": "Asia/Jerusalem", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/neuromath-carsen", "password": "", "video_on_demand": "https://youtu.be/fAFHJiqYwb8", "speaker_title": "Dr.", "seminar_speaker": "Carsen Stringer_", "speaker_affil": "Janelia Research Campus", "speaker_twitter": "@computingnature", "speaker_website": "http://www.gatsby.ucl.ac.uk/~cstringer/", "topic_tags": "theory, math", "seminar_title": "High-dimensional geometry of visual cortex", "seminar_abstract": "Interpreting high-dimensional datasets requires new computational and analytical methods. We developed such methods to extract and analyze neural activity from 20,000 neurons recorded simultaneously in awake, behaving mice. The neural activity was not low-dimensional as commonly thought, but instead was high-dimensional and obeyed a power-law scaling across its eigenvalues. We developed a theory that proposes that neural responses to external stimuli maximize information capacity while maintaining a smooth neural code. We then observed power-law eigenvalue scaling in many real-world datasets, and therefore developed a nonlinear manifold embedding algorithm called Rastermap that can capture such high-dimensional structure.", "hosted_by": "NeuroMath", "domain": ["Neuroscience"], "calendar_event_hash": "bbca3088d369a2593fbfc5c826bd27db5bd5958866adf144b351ac7e46c3733d", "seminar_id": 809, "time_of_addition": "Mon, Sep 28, 2020 11:06"}, "844": {"seminar_date": "Thu, Jun 18, 2020", "seminar_time": "16:00", "timezone": "Europe/Berlin", "posted": "yes", "seminar_link": "https://www.youtube.com/watch?v=w5T24xY2OQg&feature=youtu.be", "password": "", "video_on_demand": "https://youtu.be/t9hN0YG9GMY", "speaker_title": "Dr.", "seminar_speaker": "John D. Murray", "speaker_affil": "Yale University School of Medicine", "speaker_twitter": "@johndmurray", "speaker_website": "https://johndmurray.org", "topic_tags": "memory, computational, computational neuroscience", "seminar_title": "Geometry of Neural Computation Unifies Working Memory and Planning", "seminar_abstract": "Cognitive tasks typically require the integration of working memory, contextual processing, and planning to be carried out in close coordination. However, these computations are typically studied within neuroscience as independent modular processes in the brain. In this talk I will present an alternative view, that neural representations of mappings between expected stimuli and contingent goal actions can unify working memory and planning computations. We term these stored maps contingency representations. We developed a \"conditional delayed logic\" task capable of disambiguating the types of representations used during performance of delay tasks. Human behaviour in this task is consistent with the contingency representation, and not with traditional sensory models of working memory. In task-optimized artificial recurrent neural network models, we investigated the representational geometry and dynamical circuit mechanisms supporting contingency-based computation, and show how contingency representation explains salient observations of neuronal tuning properties in prefrontal cortex. Finally, our theory generates novel and falsifiable predictions for single-unit and population neural recordings.", "hosted_by": "Tubingen Neuro Campus", "domain": ["Neuroscience"], "calendar_event_hash": "b2404dbb11d2abf62d155c49f9f4d25acff4182244d44164818f1e44de797244", "seminar_id": 844, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "845": {"seminar_date": "Tue, Jun 23, 2020", "seminar_time": "18:00", "timezone": "Europe/Berlin", "posted": "yes", "seminar_link": "https://www.youtube.com/watch?v=qqwHQHkX0XQ", "password": "", "video_on_demand": "https://youtu.be/qqwHQHkX0XQ", "speaker_title": "Prof.", "seminar_speaker": "Marla Feller", "speaker_affil": "University of California, Berkeley", "speaker_twitter": "@FellerMarla", "speaker_website": "https://fellerlab.squarespace.com/", "topic_tags": "retina, vision, two-photon imaging, systems", "seminar_title": "Wiring up direction selective circuits in the retina", "seminar_abstract": "The development of neural circuits is profoundly impacted by both spontaneous and sensory experience. This is perhaps most well studied in the visual system, where disruption of early spontaneous activity called retinal waves prior to eye opening and visual deprivation after eye opening leads to alterations in the response properties and connectivity in several visual centers in the brain. We address this question in the retina, which comprises multiple circuits that encode different features of the visual scene, culminating in over 40 different types of retinal ganglion cells. Direction-selective ganglion cells respond strongly to an image moving in the preferred direction and weakly to an image moving in the opposite, or null, direction.  Moreover, as recently described (Sabbah et al, 2017) the preferred directions of direction selective ganglion cells cluster along four directions that align along two optic flow axes, causing variation of the relative orientation of preferred directions along the retinal surface.  I will provide recent progress in the lab that addresses the role of visual experience and spontaneous retinal waves in the establishment of direction selective tuning and direction selectivity maps in the retina.", "hosted_by": "Tubingen Neuro Campus", "domain": ["Neuroscience"], "calendar_event_hash": "ab16bc087f996cf92dd3f57ea0fc95b600b1ac084ef022dcd3db8825f92f5cb5", "seminar_id": 845, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "846": {"seminar_date": "Mon, Jun 29, 2020", "seminar_time": "15:00", "timezone": "Europe/Berlin", "posted": "yes", "seminar_link": "https://youtu.be/jPB79Eoo6Xo", "password": "", "video_on_demand": "https://youtu.be/jPB79Eoo6Xo", "speaker_title": "Prof.", "seminar_speaker": "Greg Schwartz", "speaker_affil": "Northwestern University, Feinberg School of Medicine", "speaker_twitter": "", "speaker_website": "http://schwartzlab.feinberg.northwestern.edu/", "topic_tags": "retina, vision, two-photon imaging, transcriptomics, electrophysiology", "seminar_title": "Toward a Comprehensive Classification of Mouse Retinal Ganglion Cells: Morphology, Function, Gene Expression, and Central Projections", "seminar_abstract": "I will introduce a web portal for the retinal neuroscience community to explore the catalog of mouse retinal ganglion cell (RGC) types, including data on light responses, correspondences with morphological types in EyeWire, and gene expression data from single-cell transcriptomics. Our current classification includes 43 types, accounting for 90% of the cells in EyeWire. Many of these cell types have new stories to tell, and I will cover two of them that represent opposite ends of the spectrum of levels of analysis in my lab. First, I will introduce the \u201cBursty Suppressed-by-Contrast\u201d RGC and show how its intrinsic properties rather than its synaptic inputs differentiate its function from that of a different well-known RGC type. Second, I will present the histogram of cell types that project to the Olivary Pretectal Nucleus, focusing on the recently discovered M6 ipRGC.", "hosted_by": "Tubingen Neuro Campus", "domain": ["Neuroscience"], "calendar_event_hash": "4edff038a2ed4145a577bc57c3184ffa51422f7024f424335decb8eea2b1d532", "seminar_id": 846, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "847": {"seminar_date": "Tue, Jun 30, 2020", "seminar_time": "16:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://youtu.be/Rkd_tBMNWVg", "password": "", "video_on_demand": "https://youtu.be/Rkd_tBMNWVg", "speaker_title": "Prof.", "seminar_speaker": "Andreas Tolias", "speaker_affil": "Baylor College of Medicine", "speaker_twitter": "@AndreasTolias", "speaker_website": "https://toliaslab.org/", "topic_tags": "ML, electrophysiology, vision, transcriptomics, cortex", "seminar_title": "The Fabric of the Neocortex", "seminar_abstract": "", "hosted_by": "Tubingen Neuro Campus", "domain": ["Neuroscience"], "calendar_event_hash": "0acd94cea50d595f908e4247f0331a7ab706ae6f2d315a2cb890b151a7fd0915", "seminar_id": 847, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "511": {"seminar_date": "Tue, Aug 11, 2020", "seminar_time": "15:00", "timezone": "Europe/Berlin", "posted": "yes", "seminar_link": "https://youtu.be/4SgpCHwsEJ8", "password": "", "video_on_demand": "https://youtu.be/4SgpCHwsEJ8", "speaker_title": "Assoc. Prof.", "seminar_speaker": "Michael Tri Do", "speaker_affil": "Harvard Medical School and Boston Children's Hospital", "speaker_twitter": "", "speaker_website": "https://www.hms.harvard.edu/dms/neuroscience/fac/DoMichael.php", "topic_tags": "retina, primate, electrophysiology, vision, visual science", "seminar_title": "Sensing Light for Sight and Physiological Control", "seminar_abstract": "Organisms sense light for purposes that range from recognizing objects to synchronizing activity with environmental cycles. What mechanisms serve these diverse tasks? This seminar will examine the specializations of two cell types. First are the foveal cone photoreceptors. These neurons are used by primates to see far greater detail than other mammals, which lack them. How do the biophysical properties of foveal cones support high-acuity vision? Second are the melanopsin retinal ganglion cells, which are conserved among mammals and essential for processes that include regulation of the circadian clock, sleep, and hormone levels. How do these neurons encode light, and is encoding customized for animals of different niches? In pursuing these questions, a broad goal is to learn how various levels of biological organization are shaped to behavioural needs.", "hosted_by": "Tubingen Neuro Campus", "domain": ["Neuroscience"], "calendar_event_hash": "c44a5d4e21375f0554d42a651792aaa5decfbb5291eb8f2e36c176e442c48144", "seminar_id": 511, "time_of_addition": "Mon, Aug 24, 2020 10:05"}, "512": {"seminar_date": "Tue, Sep 15, 2020", "seminar_time": "15:00", "timezone": "Europe/Berlin", "posted": "yes", "seminar_link": "https://youtu.be/O23weJtKd2o", "password": "", "video_on_demand": "", "speaker_title": "Ass. Prof.", "seminar_speaker": "Shreejoy Tripathy", "speaker_affil": "University of Toronto", "speaker_twitter": "@neuronjoy", "speaker_website": "https://triplab.org", "topic_tags": "computational, electrophysiology, computational neuroscience", "seminar_title": "Bridging computational neuroscience and genomics in the era of big data", "seminar_abstract": "", "hosted_by": "Tubingen Neuro Campus", "domain": ["Neuroscience"], "calendar_event_hash": "8b0e8c59fb41f6a0c61905f84f775784ce8698903210574a7f6aec9996cb9c5b", "seminar_id": 512, "time_of_addition": "Mon, Aug 24, 2020 10:05"}, "513": {"seminar_date": "Mon, Sep 21, 2020", "seminar_time": "16:00", "timezone": "Europe/Berlin", "posted": "yes", "seminar_link": "https://youtu.be/Wfj1hi3EISY", "password": "", "video_on_demand": "", "speaker_title": "Prof.", "seminar_speaker": "Tiffany Schmidt", "speaker_affil": "Northwestern University", "speaker_twitter": "@tiffmschmidt", "speaker_website": "http://www.schmidtlab-northwestern.com/", "topic_tags": "retina, vision, behaviour, visual science", "seminar_title": "Illuminating Circadian Circuits", "seminar_abstract": "Proper alignment of the circadian system the environmental light/dark cycle is central to human health and well-being, and occurs exclusively via light input from the melanopsin-expressing, intrinsically photosensitive retinal ganglion cells (ipRGCs). I will discuss our lab\u2019s recent work uncovering a new inhibitory signaling pathway from the eye to the brain that dampens the sensitivity of our circadian and pupil systems to light.", "hosted_by": "Tubingen Neuro Campus", "domain": ["Neuroscience"], "calendar_event_hash": "70f562567a450f54aad258841f54307730d8c63938d9886f6f3cdfde728a7229", "seminar_id": 513, "time_of_addition": "Mon, Aug 24, 2020 10:05"}, "514": {"seminar_date": "Tue, Sep 22, 2020", "seminar_time": "16:00", "timezone": "Europe/Berlin", "posted": "yes", "seminar_link": "https://youtu.be/QzU9YwxTD7o", "password": "", "video_on_demand": "", "speaker_title": "Assoc. Prof.", "seminar_speaker": "Stephanie Palmer", "speaker_affil": "The University of Chicago", "speaker_twitter": "@sepalmerNeuro", "speaker_website": "https://oba.bsd.uchicago.edu/faculty/stephanie-palmer-phd", "topic_tags": "retina, vision, behaviour, visual science", "seminar_title": "How behavioral and evolution constraints sculpt early visual processing", "seminar_abstract": "", "hosted_by": "Tubingen Neuro Campus", "domain": ["Neuroscience"], "calendar_event_hash": "0c2840f13f846bf3b7fa5495ac67f0c7b63ab81959a18efc14c48d32dfd116f4", "seminar_id": 514, "time_of_addition": "Mon, Aug 24, 2020 10:05"}, "515": {"seminar_date": "Tue, Oct 13, 2020", "seminar_time": "17:00", "timezone": "Europe/Berlin", "posted": "yes", "seminar_link": "https://youtu.be/3X6zV4tYvaQ", "password": "", "video_on_demand": "", "speaker_title": "Dr.", "seminar_speaker": "Saskia de Vries", "speaker_affil": "Allen Institute for Brain Science, Seattle", "speaker_twitter": "", "speaker_website": "https://alleninstitute.org/what-we-do/brain-science/about/team/staff-profiles/saskia-de-vries/", "topic_tags": "", "seminar_title": "", "seminar_abstract": "", "hosted_by": "Tubingen Neuro Campus", "domain": ["Neuroscience"], "calendar_event_hash": "cb5d3d29adb5b4a77ff9907f2c62e1739d9cb3b4b91500399e18e0122566c262", "seminar_id": 515, "time_of_addition": "Mon, Aug 24, 2020 10:05"}, "900": {"seminar_date": "Mon, Jul 6, 2020", "seminar_time": "15:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/nate-sawtells-world-wide", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Nate Sawtell", "speaker_affil": "Columbia University", "speaker_twitter": "", "speaker_website": "https://sawtell-lab.neuroscience.columbia.edu/content/about-us", "topic_tags": "electrophysiology, learning, plasticity, information processing", "seminar_title": "Synaptic, cellular, and circuit mechanisms for learning: insights from electric fish", "seminar_abstract": "Understanding learning in neural circuits requires answering a number of difficult questions: (1) What is the computation being performed and what is its behavioral significance? (2) What are the inputs required for the computation and how are they represented at the level of spikes? (3) What are the sites and rules governing plasticity, i.e. how do pre and post-synaptic activity patterns produce persistent changes in synaptic strength? (4) How does network connectivity and dynamics shape the computation being performed? I will discuss joint experimental and theoretical work addressing these questions in the context of the electrosensory lobe (ELL) of weakly electric mormyrid fish.", "hosted_by": "Crick Neurophys", "domain": ["Neuroscience"], "calendar_event_hash": "7664d08916d215c15f42536de9fd281729ee6be48583769482e8f6bf5dabb4a5", "seminar_id": 900, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "901": {"seminar_date": "Wed, Sep 23, 2020", "seminar_time": "12:00", "timezone": "Europe/London", "posted": "Yes", "seminar_link": "https://youtu.be/Fx8NEVtE37U", "password": "", "video_on_demand": "", "speaker_title": "Dr.", "seminar_speaker": "Marta Andres Miguel", "speaker_affil": "UCL", "speaker_twitter": "@martaandresm", "speaker_website": "https://www.ucl.ac.uk/ear/research/fellowship-pages/fellowship-labpage-marta-andres-miguel", "topic_tags": "behaviour, hearing, neuromodulation", "seminar_title": "", "seminar_abstract": "", "hosted_by": "Crick Neurophys", "domain": ["Neuroscience"], "calendar_event_hash": "722a2bffb77dd478acbda4709f13806f74f47b17d2162e1174e05a34d404cafb", "seminar_id": 901, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "848": {"seminar_date": "Thu, May 7, 2020", "seminar_time": "15:59", "timezone": "America/Los_Angeles", "posted": "yes", "seminar_link": "https://uoregon.zoom.us/j/91824451598?pwd=S2hUZ2dscVI3cU40Wk1TanlQMEt3UT09", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Larry Abbott", "speaker_affil": "Columbia University", "speaker_twitter": "", "speaker_website": "https://neuroscience.columbia.edu/profile/larryabbott", "topic_tags": "theory, invertebrate, balance", "seminar_title": "Multi-layer network learning in an electric fish", "seminar_abstract": "The electrosensory lobe (ELL) in mormyrid electric fish is a cerebellar-like structure that cancels the sensory effects of self-generated electric fields, allowing prey to be detected. Like the cerebellum, the ELL involves two stages of processing, analogous to the Purkinje cells and cells of the deep cerebellar nuclei. Through the work of Curtis Bell and others, a model was previously developed to describe the output stage of the ELL, but the role of the Purkinje-cell analogs, the medium ganglion (MG) cells, in the circuit had remained mysterious. I will present a complete, multi-layer circuit description of the ELL, developed in collaboration with Nate Sawtell and Salomon Muller, that reveals a novel role for the MG cells. The resulting model provides an example of how a biological system solves well-known problems associated with learning in multi-layer networks, and it reveals that ELL circuitry is organization on the basis of learning rather than by the response properties of neurons.", "hosted_by": "U Oregon Neuro", "domain": ["Neuroscience"], "calendar_event_hash": "782799d1d3306f7d1ad48d7f0a646aecbd5dccf7e534a99481d2fb2e584888d9", "seminar_id": 848, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "849": {"seminar_date": "Thu, May 14, 2020", "seminar_time": "12:00", "timezone": "America/Los_Angeles", "posted": "yes", "seminar_link": "https://uoregon.zoom.us/j/92382152695?pwd=MmtabWFyZDJjVU9lQVowVjJyTVhjdz09", "password": "276618", "video_on_demand": "", "speaker_title": "Dr", "seminar_speaker": "Cindy Poo", "speaker_affil": "Champalimaud", "speaker_twitter": "", "speaker_website": "http://neuro.fchampalimaud.org/en/research/investigators/research-groups/group/Mainen/", "topic_tags": "systems", "seminar_title": "Cortical circuits for olfactory navigation", "seminar_abstract": "Olfactory navigation is essential for the survival of living beings from unicellular organisms to mammals. In the wild, rodents combine odor information with an internal spatial representation of the environment for foraging and navigation. What are the neural circuits in the brain that implement these behaviours? My research addresses this question by examining the synaptic circuits and neural population activity in the olfactory cortex to understand the integration of olfactory and spatial information. Primary olfactory (piriform) cortex (PCx) has long been recognized as a highly associative brain structure. What is the behavioural and functional role of these associative synapses in PCx? We designed an odor-cued navigation task, where rats must use both olfactory and spatial information to obtain water rewards. We recorded from populations of posterior piriform cortex (pPCx) neurons during behaviour and found that individual neurons were not only odor-selective, but also fired differentially to the same odor sampled at different locations, forming an \u201colfactory place map\u201d. Spatial locations can be decoded from simultaneously recorded pPCx population, and spatial selectivity is maintained in the absence of odors, across behavioural contexts. This novel olfactory place map is consistent with our finding for a dominant role of associative excitatory synapses in shaping PCx representations, and suggest a role for PCx spatial representations in supporting olfactory navigation. This work not only provides insight into the neural basis for how odors can be used for navigation, but also reveals PCx as a prime site for addressing the general question of how sensory information is anchored within memory systems and combined with cognitive maps to guide flexible behaviour.", "hosted_by": "U Oregon Neuro", "domain": ["Neuroscience"], "calendar_event_hash": "e9f5630d4ffcc34bb41523b0f3bd9575c4c487ee4179ec8e8e7628dec017cbb1", "seminar_id": 849, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "850": {"seminar_date": "Tue, May 19, 2020", "seminar_time": "16:00", "timezone": "America/Los_Angeles", "posted": "yes", "seminar_link": "https://uoregon.zoom.us/j/92792174660?pwd=WGkvVjZtcVV1K3pOS0Rpd1ZhZHkxZz09", "password": "", "video_on_demand": "", "speaker_title": "Dr", "seminar_speaker": "Laureline Logiaco", "speaker_affil": "Columbia University", "speaker_twitter": "", "speaker_website": "", "topic_tags": "theory", "seminar_title": "Flexible motor sequencing through thalamic control of cortical dynamics", "seminar_abstract": "The mechanisms by which neural circuits generate an extensible library of motor motifs and flexibly string them into arbitrary sequences are unclear. We developed a model in which inhibitory basal ganglia output neurons project to thalamic units that are themselves bidirectionally connected to a recurrent cortical network. During movement sequences, electrophysiological recordings of basal ganglia output neurons show sustained activity patterns that switch at the boundaries between motifs. Thus, we model these inhibitory patterns as silencing some thalamic neurons while leaving others disinhibited and free to interact with cortex during specific motifs. We show that a small number of disinhibited thalamic neurons can control cortical dynamics to generate specific motor output in a noise robust way. If the thalamic units associated with each motif are segregated, many motor outputs can be learned without interference and then combined in arbitrary orders for the flexible production of long and complex motor sequences.", "hosted_by": "U Oregon Neuro", "domain": ["Neuroscience"], "calendar_event_hash": "a1c9c460a3c4c7c95499ea1094669b05a4b04541d69377d1d28d605d055619b9", "seminar_id": 850, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "573": {"seminar_date": "Wed, Sep 16, 2020", "seminar_time": "12:00", "timezone": "America/Los_Angeles", "posted": "yes", "seminar_link": "https://uoregon.zoom.us/j/95289060640?pwd=L1pqYU5TMzdEODBlcFNYWURUTzFxZz09", "password": "691984", "video_on_demand": "", "speaker_title": "Dr", "seminar_speaker": "Kamesh Krishnamurthy", "speaker_affil": "Princeton University", "speaker_twitter": "", "speaker_website": "https://kameshkk.github.io/", "topic_tags": "theory, machine learning", "seminar_title": "Theory of gating in recurrent neural networks", "seminar_abstract": "Recurrent neural networks (RNNs) are powerful dynamical models, widely used in machine learning (ML) for processing sequential data, and also in neuroscience, to understand the emergent properties of networks of real neurons. Prior theoretical work in understanding the properties of RNNs has focused on models with additive interactions. However, real neurons can have gating i.e. multiplicative interactions, and gating is also a central feature of the best performing RNNs in machine learning. Here, we develop a dynamical mean-field theory (DMFT) to study the consequences of gating in RNNs. We use random matrix theory to show how gating robustly produces marginal stability and line attractors \u2013 important mechanisms for biologically-relevant computations requiring long memory. The long-time behavior of the gated network is studied using its Lyapunov spectrum, and the DMFT is used to provide a novel analytical expression for the maximum Lyapunov exponent demonstrating its close relation to relaxation-time of the dynamics. Gating is also shown to give rise to a novel, discontinuous transition to chaos, where the proliferation of critical points (topological complexity) is decoupled from the appearance of chaotic dynamics (dynamical complexity), contrary to a seminal result for additive RNNs. Critical surfaces and regions of marginal stability in the parameter space are indicated in phase diagrams, thus providing a map for principled parameter choices for ML practitioners. Finally, we develop a field-theory for gradients that arise in training, by incorporating the adjoint sensitivity framework from control theory in the DMFT. This paves the way for the use of powerful field-theoretic techniques to study training/gradients in large RNNs.", "hosted_by": "U Oregon Neuro", "domain": ["Neuroscience"], "calendar_event_hash": "275e16923f5cf3cea554e18142376cea7812c61a128d2f46f78409202142a48b", "seminar_id": 573, "time_of_addition": "Thu, Sep 03, 2020 18:31"}, "830": {"seminar_date": "Wed, Jun 24, 2020", "seminar_time": "17:00", "timezone": "Europe/Berlin", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/k9zn5mmo", "password": "Mail to smartstart@fz-juelich.de to get the password", "video_on_demand": "https://vimeo.com/manage/showcases/6262239/info", "speaker_title": "Prof", "seminar_speaker": "Constantin Rothkopf", "speaker_affil": "TU Darmstadt", "speaker_twitter": "@NNCN_Germany", "speaker_website": "https://www.smartstart-compneuro.de/", "topic_tags": "computational neuroscience, cognitive science, psychology, information processing, visual science", "seminar_title": "MidsummerBrains - computational neuroscience from my point of view", "seminar_abstract": "Computational neuroscience is a highly interdisciplinary field ranging from mathematics, physics and engineering to biology, medicine and psychology.\n\nInterdisciplinary collaborations have resulted in many groundbreaking innovations both in the research and application. The basis for successful \ncollaborations is the ability to communicate across disciplines: What projects are the others working on? Which techniques and methods are they using? How is data collected, used and stored?\n\nIn this webinar series, several experts describe their view on computational neuroscience in theory and application, and share experiences they had with interdisciplinary projects.\nThis webinar is open for all interested students and researchers. If you are interested to participate live, please send a short message to \nsmartstart@fz-juelich.de\n\nPlease note, these lectures will be recorded for subsequent publishing as online lecture material.", "hosted_by": "SMARTSTART Midsummer Brains", "domain": ["Neuroscience"], "calendar_event_hash": "92d894cf96bbe9ebb20bed489608916194fa579bf7b514496c862b78348c16e9", "seminar_id": 830, "time_of_addition": "Mon, Sep 28, 2020 11:06"}, "831": {"seminar_date": "Tue, Jun 30, 2020", "seminar_time": "17:00", "timezone": "Europe/Berlin", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/k9zn5mmo", "password": "Mail to smartstart@fz-juelich.de to get the password", "video_on_demand": "https://vimeo.com/manage/showcases/6262239/info", "speaker_title": "Prof", "seminar_speaker": "Hermann Cuntz", "speaker_affil": "Ernst Str\u00fcngmann Institute & Frankfurt Institute for Advanced Studies", "speaker_twitter": "@NNCN_Germany", "speaker_website": "https://www.smartstart-compneuro.de/", "topic_tags": "computational neuroscience, cognitive science, psychology, information processing, visual science", "seminar_title": "MidsummerBrains - computational neuroscience from my point of view", "seminar_abstract": "Computational neuroscience is a highly interdisciplinary field ranging from mathematics, physics and engineering to biology, medicine and psychology.\n\nInterdisciplinary collaborations have resulted in many groundbreaking innovations both in the research and application. The basis for successful \ncollaborations is the ability to communicate across disciplines: What projects are the others working on? Which techniques and methods are they using? How is data collected, used and stored?\n\nIn this webinar series, several experts describe their view on computational neuroscience in theory and application, and share experiences they had with interdisciplinary projects.\nThis webinar is open for all interested students and researchers. If you are interested to participate live, please send a short message to \nsmartstart@fz-juelich.de\n\nPlease note, these lectures will be recorded for subsequent publishing as online lecture material.", "hosted_by": "SMARTSTART Midsummer Brains", "domain": ["Neuroscience"], "calendar_event_hash": "b4b8fcc387673cf25100ac5ae0c063c975796cee2c4ca4b1f45818b3e79c81e5", "seminar_id": 831, "time_of_addition": "Mon, Sep 28, 2020 11:06"}, "832": {"seminar_date": "Wed, Jul 1, 2020", "seminar_time": "17:00", "timezone": "Europe/Berlin", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/k9zn5mmo", "password": "Mail to smartstart@fz-juelich.de to get the password", "video_on_demand": "https://vimeo.com/manage/showcases/6262239/info", "speaker_title": "Prof", "seminar_speaker": "Jutta Kretzberg", "speaker_affil": "University of Oldenburg", "speaker_twitter": "@NNCN_Germany", "speaker_website": "https://www.smartstart-compneuro.de/", "topic_tags": "computational neuroscience, cognitive science, psychology, information processing, visual science", "seminar_title": "MidsummerBrains - computational neuroscience from my point of view", "seminar_abstract": "Computational neuroscience is a highly interdisciplinary field ranging from mathematics, physics and engineering to biology, medicine and psychology.\n\nInterdisciplinary collaborations have resulted in many groundbreaking innovations both in the research and application. The basis for successful \ncollaborations is the ability to communicate across disciplines: What projects are the others working on? Which techniques and methods are they using? How is data collected, used and stored?\n\nIn this webinar series, several experts describe their view on computational neuroscience in theory and application, and share experiences they had with interdisciplinary projects.\nThis webinar is open for all interested students and researchers. If you are interested to participate live, please send a short message to \nsmartstart@fz-juelich.de\n\nPlease note, these lectures will be recorded for subsequent publishing as online lecture material.", "hosted_by": "SMARTSTART Midsummer Brains", "domain": ["Neuroscience"], "calendar_event_hash": "b5aef788a7ad6c1c1997e13691ba3e74e6dd9a76e0271e99479105644e0f3292", "seminar_id": 832, "time_of_addition": "Mon, Sep 28, 2020 11:06"}, "833": {"seminar_date": "Wed, Jul 8, 2020", "seminar_time": "17:00", "timezone": "Europe/Berlin", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/k9zn5mmo", "password": "Mail to smartstart@fz-juelich.de to get the password", "video_on_demand": "https://vimeo.com/manage/showcases/6262239/info", "speaker_title": "Dr", "seminar_speaker": "Katharina Wilmes", "speaker_affil": "University of Bern", "speaker_twitter": "@NNCN_Germany", "speaker_website": "https://www.smartstart-compneuro.de/", "topic_tags": "computational neuroscience, cognitive science, psychology, information processing, visual science", "seminar_title": "MidsummerBrains - computational neuroscience from my point of view", "seminar_abstract": "Computational neuroscience is a highly interdisciplinary field ranging from mathematics, physics and engineering to biology, medicine and psychology.\n\nInterdisciplinary collaborations have resulted in many groundbreaking innovations both in the research and application. The basis for successful \ncollaborations is the ability to communicate across disciplines: What projects are the others working on? Which techniques and methods are they using? How is data collected, used and stored?\n\nIn this webinar series, several experts describe their view on computational neuroscience in theory and application, and share experiences they had with interdisciplinary projects.\nThis webinar is open for all interested students and researchers. If you are interested to participate live, please send a short message to \nsmartstart@fz-juelich.de\n\nPlease note, these lectures will be recorded for subsequent publishing as online lecture material.", "hosted_by": "SMARTSTART Midsummer Brains", "domain": ["Neuroscience"], "calendar_event_hash": "6dcc84949a22aaf1b62937f6a67223e452dbda5e1f588eccd9eae03cfcee0b59", "seminar_id": 833, "time_of_addition": "Mon, Sep 28, 2020 11:06"}, "834": {"seminar_date": "Wed, Jul 15, 2020", "seminar_time": "17:00", "timezone": "Europe/Berlin", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/k9zn5mmo", "password": "Mail to smartstart@fz-juelich.de to get the password", "video_on_demand": "https://vimeo.com/manage/showcases/6262239/info", "speaker_title": "Prof", "seminar_speaker": "Julijana Gjorgjieva", "speaker_affil": "MPI brain research", "speaker_twitter": "@NNCN_Germany", "speaker_website": "https://www.smartstart-compneuro.de/", "topic_tags": "computational neuroscience, cognitive science, psychology, information processing, visual science", "seminar_title": "MidsummerBrains - computational neuroscience from my point of view", "seminar_abstract": "Computational neuroscience is a highly interdisciplinary field ranging from mathematics, physics and engineering to biology, medicine and psychology.\n\nInterdisciplinary collaborations have resulted in many groundbreaking innovations both in the research and application. The basis for successful \ncollaborations is the ability to communicate across disciplines: What projects are the others working on? Which techniques and methods are they using? How is data collected, used and stored?\n\nIn this webinar series, several experts describe their view on computational neuroscience in theory and application, and share experiences they had with interdisciplinary projects.\nThis webinar is open for all interested students and researchers. 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"ef5708a933fbb5a5b624d15bf43bd740b7ef8152ccaa425fdb5c0a858e81e25b", "seminar_id": 1099, "time_of_addition": "Sun, Oct 04, 2020 18:35"}, "1100": {"seminar_date": "Thu, Nov 19, 2020", "seminar_time": "17:00", "timezone": "Europe/Paris", "posted": "YES", "seminar_link": "https://www.crowdcast.io/e/madeline-lancasters", "password": "", "video_on_demand": "", "speaker_title": "", "seminar_speaker": "Madeline Lancaster", "speaker_affil": "", "speaker_twitter": "", "speaker_website": "", "topic_tags": "development, organoids", "seminar_title": "", "seminar_abstract": "Host: Silvia Cappello, MPI Psychiatry Munich", "hosted_by": "WWNDev", "domain": ["Neuroscience"], "calendar_event_hash": "0bb06c724bac0a855e82fdcee91c303da8480ff71453c5d966594650a71d38d1", "seminar_id": 1100, "time_of_addition": "Sun, Oct 04, 2020 18:35"}, "1101": {"seminar_date": "Thu, Nov 26, 2020", "seminar_time": "17:00", "timezone": "Europe/Paris", "posted": "YES", "seminar_link": 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"timezone": "Europe/Paris", "posted": "YES", "seminar_link": "https://www.crowdcast.io/e/matthew-cobbs-world-wide", "password": "", "video_on_demand": "", "speaker_title": "", "seminar_speaker": "Matthew Cobb", "speaker_affil": "", "speaker_twitter": "", "speaker_website": "", "topic_tags": "history of neuroscience", "seminar_title": "", "seminar_abstract": "Host: Denis Jabaudon, University of Geneva", "hosted_by": "WWNDev", "domain": ["Neuroscience"], "calendar_event_hash": "379b7b935f63c0c9ce94bcd5bf8b278153999dbf19bb2352775f9b55a1764951", "seminar_id": 1104, "time_of_addition": "Sun, Oct 04, 2020 18:35"}, "1105": {"seminar_date": "Thu, Jan 14, 2021", "seminar_time": "17:00", "timezone": "Europe/Paris", "posted": "YES", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "", "seminar_speaker": "Oliver Hobert", "speaker_affil": "", "speaker_twitter": "", "speaker_website": "", "topic_tags": "", "seminar_title": "Circuit transcription factors in C.elegans", "seminar_abstract": "Host: Denis Jabaudon, University of Geneva", "hosted_by": "WWNDev", "domain": ["Neuroscience"], "calendar_event_hash": "96031aabf8231fc3ec352d36fb7d06c5463eeb10dbbd6c038b2310d50e34b63d", "seminar_id": 1105, "time_of_addition": "Sun, Oct 04, 2020 18:35"}, "1106": {"seminar_date": "Thu, Jan 21, 2021", "seminar_time": "17:00", "timezone": "Europe/Paris", "posted": "YES", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "", "seminar_speaker": "Claude Desplan", "speaker_affil": "", "speaker_twitter": "", "speaker_website": "", "topic_tags": "", "seminar_title": "", "seminar_abstract": "Host: Denis Jabaudon, University of Geneva", "hosted_by": "WWNDev", "domain": ["Neuroscience"], "calendar_event_hash": "db9ef934614d2d16227e970bd36756d7a1a1e47cbec71eae71ba534990f26003", "seminar_id": 1106, "time_of_addition": "Sun, Oct 04, 2020 18:35"}, "1107": {"seminar_date": "Thu, Jan 28, 2021", "seminar_time": "17:00", "timezone": "Europe/Paris", "posted": "YES", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "", "seminar_speaker": "Sten Linnarsson", "speaker_affil": "", "speaker_twitter": "", "speaker_website": "", "topic_tags": "", "seminar_title": "Brain cancer and the single-cell architecture of human brain development", "seminar_abstract": "Host: Alain Ch\u00e9dotal, Institut de la Vision, Paris", "hosted_by": "WWNDev", "domain": ["Neuroscience"], "calendar_event_hash": "aea326e742d0f3941203861d12358a2457bdfb077fc3d8dd8a0de2f5de2cd447", "seminar_id": 1107, "time_of_addition": "Sun, Oct 04, 2020 18:35"}, "1108": {"seminar_date": "Thu, Feb 4, 2021", "seminar_time": "17:00", "timezone": "Europe/Paris", "posted": "YES", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "", "seminar_speaker": "Paola Arlotta", "speaker_affil": "", "speaker_twitter": "", "speaker_website": "", "topic_tags": "", "seminar_title": "", "seminar_abstract": "Host: Silvia Cappello, MPI Psychiatry Munich", "hosted_by": "WWNDev", "domain": ["Neuroscience"], "calendar_event_hash": "26d3b7d701b93ed4edae30ae494493087228e89deda38082025f9c22ebe6e06a", "seminar_id": 1108, "time_of_addition": "Sun, Oct 04, 2020 18:35"}, "1109": {"seminar_date": "Thu, Feb 11, 2021", "seminar_time": "17:00", "timezone": "Europe/Paris", "posted": "YES", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "", "seminar_speaker": "Linda Richards", "speaker_affil": "", "speaker_twitter": "", "speaker_website": "", "topic_tags": "", "seminar_title": "", "seminar_abstract": "Host: Alain Ch\u00e9dotal, Institut de la Vision, Paris", "hosted_by": "WWNDev", "domain": ["Neuroscience"], "calendar_event_hash": "35948894b46183f3c49c7298b14cbac7e671eb329f29ac3706bc14a76ef12cb1", "seminar_id": 1109, "time_of_addition": "Sun, Oct 04, 2020 18:35"}, "1110": {"seminar_date": "Thu, Feb 18, 2021", "seminar_time": "17:00", "timezone": "Europe/Paris", "posted": "YES", "seminar_link": "", "password": "", 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"password": "", "video_on_demand": "", "speaker_title": "", "seminar_speaker": "Hongkui Zheng", "speaker_affil": "", "speaker_twitter": "", "speaker_website": "", "topic_tags": "", "seminar_title": "", "seminar_abstract": "Host: Denis Jabaudon, University of Geneva", "hosted_by": "WWNDev", "domain": ["Neuroscience"], "calendar_event_hash": "93622f84ff67031a2d13eb3b8e87a2b75ecaf8df75a6c4ac3acd838d0508aad9", "seminar_id": 1113, "time_of_addition": "Sun, Oct 04, 2020 18:36"}, "1114": {"seminar_date": "Thu, Mar 25, 2021", "seminar_time": "17:00", "timezone": "Europe/Paris", "posted": "YES", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "", "seminar_speaker": "Pavan Ramdya", "speaker_affil": "", "speaker_twitter": "", "speaker_website": "", "topic_tags": "", "seminar_title": "", "seminar_abstract": "Host: Bassem Hassan, Paris Brain Institute", "hosted_by": "WWNDev", "domain": ["Neuroscience"], "calendar_event_hash": 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Every presynapse builds a core active zone structure where ion channels are clustered and synaptic vesicles are released2. While the composition of active zones is well characterized2,3, how active zone proteins assemble together and recruit synaptic release machinery during development is not clear. Here, we find core active zone scaffold proteins SYD-2/Liprin-\u03b1 and ELKS-1 phase separate during an early stage of synapse development, and later mature into a solid structure. We directly test the in vivo function of phase separation with mutants specifically lacking this activity. These mutant SYD-2 and ELKS-1 proteins remain enriched at synapses, but are defective in active zone assembly and synapse function. The defects are rescued with the introduction of a phase separation motif from an unrelated protein. In vitro, we reconstitute the SYD-2 and ELKS-1 liquid phase scaffold and find it is competent to bind and incorporate downstream active zone components. The fluidity of SYD-2 and ELKS-1 condensates is critical for efficient mixing and incorporation of active zone components. These data reveal that a developmental liquid phase of scaffold molecules is essential for synaptic active zone assembly before maturation into a stable final structure.", "hosted_by": "Picower at MIT", "domain": ["Neuroscience"], "calendar_event_hash": "c8e964a856c092edebc4acb3597ef9a890c2e246c4e4dab982800009d25b3f35", "seminar_id": 689, "time_of_addition": "Thu, Sep 17, 2020 18:08"}, "692": {"seminar_date": "Tue, Sep 22, 2020", "seminar_time": "9:00", "timezone": "America/New_York", "posted": "yes", "seminar_link": "https://picower.mit.edu/events/aging-brain-initiative-symposium", "password": "", "video_on_demand": "", "speaker_title": "", "seminar_speaker": "David Atwell, Anne Brunet, Diane Chan, Don Cleveland, Marco Colonna, Valina Dawson, Myriam Heiman, Jonathan Kipnis, Lennart Mucke, Dorothy Schafer", "speaker_affil": "", "speaker_twitter": "", "speaker_website": "", "topic_tags": "neurodegeneration", "seminar_title": "Aging Brain Initiative Symposium: Cellular & Molecular Mechanisms of Neurodegeneration", "seminar_abstract": "The Aging Brain Initiative is an ambitious interdisciplinary effort by MIT focusing on understanding neurodegeneration and efforts to find hallmarks of aging, both in health and disease. The Initiative is broad, made up of scientists in several areas, including systems neuroscience, cell biology, engineering and computational biology, with core investigators from the Departments of Biology, Brain & Cognitive Sciences, Biological Engineering, and Computer Science & Artificial Intelligence Labs.\n\n\"The theme of this symposium is Cellular & Molecular Mechanisms of Neurodegeneration.", "hosted_by": "Picower at MIT", "domain": ["Neuroscience"], "calendar_event_hash": "f5bee109b39618269981e42b21b42e6b58993f5d1dcb343d85da52abc726abdc", "seminar_id": 692, "time_of_addition": "Fri, Sep 18, 2020 23:50"}, "319": {"seminar_date": "Mon, Apr 20, 2020", "seminar_time": "16:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://cortexclub.com/join-us/", "password": "", "video_on_demand": "", "speaker_title": "Prof.", "seminar_speaker": "Constance Cepko", "speaker_affil": "Harvard Medical School & HHMI", "speaker_twitter": "", "speaker_website": "https://cepko.hms.harvard.edu", "topic_tags": "genetics, retina, development", "seminar_title": "Cell Fate Determination in the Retina", "seminar_abstract": "The Cepko lab investigates the mechanisms that direct development of the central nervous system (CNS) of vertebrates, with a focus on the retina. These studies have revealed that the retina has distinct types of progenitor cells that are biased, or committed, to produce distinct types of daughter cells in terminal divisions. The gene regulatory networks that underlie these cell fate choices are being studied by analysis of both gene function and cis-regulatory networks. New methods that enable these studies have been developed, including high throughput enhancer assays and quantitative, inexpensive and sensitive multiplex in situ hybridization methods.", "hosted_by": "Cortex Club", "domain": ["Neuroscience"], "calendar_event_hash": "a7d9bd490a2a0fe1f28ff697b28159d334789e22bc8da8f180f950acdc089891", "seminar_id": 319, "time_of_addition": "Fri, Jul 03, 2020 14:00"}, "320": {"seminar_date": "Thu, Apr 30, 2020", "seminar_time": "11:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://cortexclub.com/join-us/", "password": "", "video_on_demand": "", "speaker_title": "Prof.", "seminar_speaker": "Bruno van Swinderen", "speaker_affil": "University of Queensland", "speaker_twitter": "@vanswinderenlab", "speaker_website": "https://www.vanswinderenlab.com", "topic_tags": "drosophila, sleep", "seminar_title": "A paradoxical kind of sleep In Drosophila melanogaster", "seminar_abstract": "The dynamic nature of sleep in most animals suggests distinct stages which serve different functions. Genetic sleep induction methods in animal models provide a powerful way to disambiguate these stages and functions, although behavioural methods alone are insufficient to accurately identify what kind of sleep is being engaged. In Drosophila, activation of the dorsal fan-shaped body (dFB) promotes sleep, but it remains unclear what kind of sleep this is, how the rest of the fly brain is behaving, or if any specific sleep functions are being achieved. Here, we developed a method to record calcium activity from thousands of neurons across a volume of the fly brain during dFB-induced sleep, and we compared this to the effects of a sleep-promoting drug. We found that drug-induced spontaneous sleep decreased brain activity and connectivity, whereas dFB sleep was not different from wakefulness. Paradoxically, dFB-induced sleep was found to be even deeper than drug- induced sleep. When we probed the sleeping fly brain with salient visual stimuli, we found that the activity of visually-responsive neurons was blocked by dFB activation, confirming a disconnect from the external environment. Prolonged optogenetic dFB activation nevertheless achieved a significant sleep function, by correcting visual attention defects brought on by sleep deprivation. These results suggest that dFB activation promotes a distinct form of sleep in Drosophila, where brain activity and connectivity remain similar to wakefulness, but responsiveness to external sensory stimuli is profoundly suppressed.", "hosted_by": "Cortex Club", "domain": ["Neuroscience"], "calendar_event_hash": "251c341b64ba76c5ef850dcc395aef9db5f39f7a207956f668c941755c4700b9", "seminar_id": 320, "time_of_addition": "Fri, Jul 03, 2020 14:00"}, "897": {"seminar_date": "Thu, May 21, 2020", "seminar_time": "16:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://cortexclub.com/join-us/", "password": "", "video_on_demand": "", "speaker_title": "Dr", "seminar_speaker": "Lorenz Fenk", "speaker_affil": "Max Planck Institute for Brain Research", "speaker_twitter": "", "speaker_website": "", "topic_tags": "claustrum, sleep", "seminar_title": "Dragons, Sleep, and the Claustrum", "seminar_abstract": "The mammalian claustrum, by virtue of its dense interconnectivity with cortex and other brain structures, has been hypothesized to mediate functions ranging from decision making to consciousness. I will be presenting experimental evidence for the existence of a claustrum in reptiles, its role in generating brain dynamics characteristic of sleep, and discuss our neuroetholgical approach towards understanding fundamental aspects of sleep and claustrum function.", "hosted_by": "Cortex Club", "domain": ["Neuroscience"], "calendar_event_hash": "9f3c5a6c76af5d8d8097aebc2f20a957dc80dfc9ed25bb0e390b33a800fca29c", "seminar_id": 897, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "321": {"seminar_date": "Thu, Jun 4, 2020", "seminar_time": "14:30", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://cortexclub.com/event/high-precision-coding-in-visual-cortex/", "password": "", "video_on_demand": "", "speaker_title": "Dr", "seminar_speaker": "Carsen Stringer", "speaker_affil": "HHMI Janelia Research Campus", "speaker_twitter": "@computingnature", "speaker_website": "http://www.gatsby.ucl.ac.uk/~cstringer/", "topic_tags": "computational, visual cortex", "seminar_title": "High precision coding in visual cortex", "seminar_abstract": "Single neurons in visual cortex provide unreliable measurements of visual features due to their high trial-to-trial variability. It is not known if this \u201cnoise\u201d extends its effects over large neural populations to impair the global encoding of stimuli. We recorded simultaneously from \u223c20,000 neurons in mouse primary visual cortex (V1) and found that the neural populations had discrimination thresholds of \u223c0.34\u00b0 in an orientation decoding task. These thresholds were nearly 100 times smaller than those reported behaviourally in mice. The discrepancy between neural and behavioural discrimination could not be explained by the types of stimuli we used, by behavioural states or by the sequential nature of perceptual learning tasks. Furthermore, higher-order visual areas lateral to V1 could be decoded equally well. These results imply that the limits of sensory perception in mice are not set by neural noise in sensory cortex, but by the limitations of downstream decoders.", "hosted_by": "Cortex Club", "domain": ["Neuroscience"], "calendar_event_hash": "d3277069c47981d5348da41e1596d3f80e1df67a97e551e81e7f3c696dbf57b6", "seminar_id": 321, "time_of_addition": "Fri, Jul 03, 2020 14:00"}, "322": {"seminar_date": "Thu, Jun 11, 2020", "seminar_time": "17:30", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://cortexclub.com/event/striatal-circuits-for-reward-learning-and-decision-making/", "password": "", "video_on_demand": "", "speaker_title": "Prof.", "seminar_speaker": "Ilana Witten", "speaker_affil": "Princeton University", "speaker_twitter": "@IlanaWitten", "speaker_website": "https://wittenlab.org", "topic_tags": "decision-making, reward learning", "seminar_title": "Striatal circuits for reward learning and decision-making", "seminar_abstract": "How are actions linked with subsequent outcomes to guide choices? The nucleus accumbens (NAc), which is implicated in this process, receives glutamatergic inputs from the prelimbic cortex (PL) and midline regions of the thalamus (mTH). However, little is known about what is represented in PL or mTH neurons that project to NAc (PL-NAc and mTH-NAc). By comparing these inputs during a reinforcement learning task in mice, we discovered that i) PL-NAc preferentially represents actions and choices, ii) mTH-NAc preferentially represents cues, iii) choice-selective activity in PL-NAc is organized in sequences that persist beyond the outcome. Through computational modelling, we demonstrate that these sequences can support the neural implementation of temporal difference learning, a powerful algorithm to connect actions and outcomes across time. Finally, we test and confirm predictions of our circuit model by direct manipulation of PL-NAc neurons. Thus, we integrate experiment and modelling to suggest a neural solution for credit assignment.", "hosted_by": "Cortex Club", "domain": ["Neuroscience"], "calendar_event_hash": "ee233cf1ae59c0d1404189e75368ddebb54b6467abc2f13821bcbdc63a4a70be", "seminar_id": 322, "time_of_addition": "Fri, Jul 03, 2020 14:00"}, "323": {"seminar_date": "Tue, Jun 23, 2020", "seminar_time": "14:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://cortexclub.com/event/mini-symposium-on-the-neuroscience-of-cognitive-development/", "password": "", "video_on_demand": "", "speaker_title": "Profs", "seminar_speaker": "Gaia Scerif & Kirsten Donald", "speaker_affil": "University of Oxford & University of Cape Town", "speaker_twitter": "@GaiaScerif; @KirstyDonald7", "speaker_website": "", "topic_tags": "cognitive development", "seminar_title": "Mini-symposium on the Neuroscience of Cognitive Development", "seminar_abstract": "Speakers will highlight research on the developmental processes underlying cognitive control and the effects of environmental risk factors on neural pathways in human cognitive development. Gaia Scerif, from University of Oxford, will be giving a talk on Using developmental cognitive neuroscience tools to investigate mechanisms of atypical cognitive control, followed by Kirsten Donald, from University of Cape Town, who will give a talk titled Neuroimaging the very young high risk brain: lessons from a south African birth cohort.", "hosted_by": "Cortex Club", "domain": ["Neuroscience"], "calendar_event_hash": "b760c503bf60c4d5eb3e557a56c852c731fe523ee4675c7c6fcbbc5df81b5b37", "seminar_id": 323, "time_of_addition": "Fri, Jul 03, 2020 14:00"}, "898": {"seminar_date": "Thu, Jun 25, 2020", "seminar_time": "17:30", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://cortexclub.com/event/hippocampal-disinhibitory-circuits-cell-types-connectivity-and-function/", "password": "", "video_on_demand": "", "speaker_title": "Prof.", "seminar_speaker": "Lisa Topolnik", "speaker_affil": "Universit\u00e9 Laval", "speaker_twitter": "", "speaker_website": "http://www.crchudequebec.ulaval.ca/en/research/researchers/lisa-topolnik/", "topic_tags": "hippocampus, circuits", "seminar_title": "Hippocampal disinhibitory circuits: cell types, connectivity and function", "seminar_abstract": "The concept of a dynamic excitation / inhibition ratio, that can shape information flow in cortical circuits during complex behavioural tasks due to circuit disinhibition, has recently arisen as an important and conserved processing motif. It has been also recognized that, in cortical circuits, a subpopulation of GABAergic cells that express vasoactive intestinal polypeptide (VIP) innervates selectively inhibitory interneurons, providing for circuit disinhibition as a possible outcome, depending on the network state and behavioural context. In this talk, I will highlight the latest discoveries on the dynamic organization of hippocampal disinhibitory circuits with a focus on VIP-expressing interneurons. I will discuss the neuron types that can be involved in disinhibition and their local circuit and long-range synaptic connections. I will also discuss some recent findings on how hippocampal VIP circuits may coordinate spatial learning.", "hosted_by": "Cortex Club", "domain": ["Neuroscience"], "calendar_event_hash": "c9a6f27a04010ffe08a4e8befd21165508ca57ed9a2a9d1ba2b1f8a9bf55c99c", "seminar_id": 898, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "899": {"seminar_date": "Tue, Jun 30, 2020", "seminar_time": "16:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://cortexclub.com/event/cortical-population-coding-of-consumption-decisions/", "password": "", "video_on_demand": "", "speaker_title": "Prof.", "seminar_speaker": "Donald B. Katz", "speaker_affil": "Brandeis University", "speaker_twitter": "", "speaker_website": "https://www.brandeis.edu/facultyguide/person.html?emplid=ecb8bfb8e5f5382b0360f0285a6acf7db248807f", "topic_tags": "population coding, consumption decisions", "seminar_title": "Cortical population coding of consumption decisions", "seminar_abstract": "The moment that a tasty substance enters an animal\u2019s mouth, the clock starts ticking. Taste information transduced on the tongue signals whether a potential food will nourish or poison, and the animal must therefore use this information quickly if it is to decide whether the food should be swallowed or expelled. The system tasked with computing this important decision is rife with cross-talk and feedback\u2014circuitry that all but ensures dynamics and between-neuron coupling in neural responses to tastes. In fact, cortical taste responses, rather than simply reporting individual taste identities, do contain characterizable dynamics: taste-driven firing first reflects the substance\u2019s presence on the tongue, and then broadly codes taste quality, and then shifts again to correlate with the taste\u2019s current palatability\u2014the basis of consumption decisions\u2014all across the 1-1.5 seconds after taste administration. Ensemble analyses reveal the onset of palatability-related firing to be a sudden, nonlinear transition happening in many neurons simultaneously, such that it can be reliably detected in single trials. This transition faithfully predicts both the nature and timing of consumption behaviours, despite the huge trial-to-trial variability in both; furthermore, perturbations of this transition interfere with production of the behaviours. These results demonstrate the specific importance of ensemble dynamics in the generation of behaviour, and reveal the taste system to be akin to a range of other integrated sensorimotor systems.", "hosted_by": "Cortex Club", "domain": ["Neuroscience"], "calendar_event_hash": "2766f671103160f4e7215d172bb70cb20f5fba524024519aac4bc5fd13f6dd0e", "seminar_id": 899, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "324": {"seminar_date": "Fri, Jul 3, 2020", "seminar_time": "16:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://cortexclub.com/event/networks-thinking-themselves/", "password": "", "video_on_demand": "", "speaker_title": "Prof.", "seminar_speaker": "Danielle S. Bassett", "speaker_affil": "University of Pennsylvania & the Santa Fe Institute", "speaker_twitter": "@DaniSBassett", "speaker_website": "https://complexsystemsupenn.com", "topic_tags": "network neuroscience", "seminar_title": "Networks thinking themselves", "seminar_abstract": "Human learners acquire not only disconnected bits of information, but complex interconnected networks of relational knowledge. The capacity for such learning naturally depends on the architecture of the knowledge network itself, and also on the architecture of the computational unit \u2013 the brain \u2013 that encodes and processes the information. Here, I will discuss emerging work assessing network constraints on the learnability of relational knowledge, and the neural correlates of that learning.", "hosted_by": "Cortex Club", "domain": ["Neuroscience"], "calendar_event_hash": "02eeba9628dd9886c8023166b05f3a0c195d9a74a88cb056181c82528b42992c", "seminar_id": 324, "time_of_addition": "Fri, Jul 03, 2020 14:00"}, "336": {"seminar_date": "Thu, Jul 9, 2020", "seminar_time": "17:30", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://cortexclub.com/event/machine-reasoning-in-histopathologic-image-analysis/", "password": "", "video_on_demand": "", "speaker_title": "Prof.", "seminar_speaker": "Phedias Diamandis", "speaker_affil": "University of Toronto", "speaker_twitter": "@pdiamandisii", "speaker_website": "https://www.diamandis.org", "topic_tags": "neuropathology, machine learning, image analysis", "seminar_title": "Machine reasoning in histopathologic image analysis", "seminar_abstract": "Deep learning is an emerging computational approach inspired by the human brain\u2019s neural connectivity that has transformed machine-based image analysis. By using histopathology as a model of an expert-level pattern recognition exercise, we explore the ability for humans to teach machines to learn and mimic image-recognition and decision making. Moreover, these models also allow exploration into the ability for computers to independently learn salient histological patterns and complex ontological relationships that parallel biological and expert knowledge without the need for explicit direction or supervision. Deciphering the overlap between human and unsupervised machine reasoning may aid in eliminating biases and improving automation and accountability for artificial intelligence-assisted vision tasks and decision-making.   Aleksandar Ivanov Title:", "hosted_by": "Cortex Club", "domain": ["Neuroscience"], "calendar_event_hash": "fa4026f6440200dee08452cd9c959f946497e5a4b406dbc321d7211547086553", "seminar_id": 336, "time_of_addition": "Mon, Jul 06, 2020 13:35"}, "346": {"seminar_date": "Fri, Jul 17, 2020", "seminar_time": "16:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://cortexclub.com/event/emergent-scientists-seminar-series/", "password": "", "video_on_demand": "", "speaker_title": "", "seminar_speaker": "Dr Jennifer Lawlor & Mr Aleksandar Ivanov", "speaker_affil": "Johns Hopkins University / University of Oxford", "speaker_twitter": "@phant0msp1k3", "speaker_website": "https://www.kishorelab.org/team & https://www.dpag.ox.ac.uk/team/aleksandar-ivanov", "topic_tags": "auditory neuroscience, auditory cortex, cortex, sensory neuroscience", "seminar_title": "Neural coding in the auditory cortex - \"Emergent Scientists Seminar Series", "seminar_abstract": "Dr Jennifer Lawlor Title: Tracking changes in complex auditory scenes along the cortical pathway Complex acoustic environments, such as a busy street, are characterised by their everchanging dynamics. Despite their complexity, listeners can readily tease apart relevant changes from irrelevant variations. This requires continuously tracking the appropriate sensory evidence while discarding noisy acoustic variations. Despite the apparent simplicity of this perceptual phenomenon, the neural basis of the extraction of relevant information in complex continuous streams for goal-directed behavior is currently not well understood. As a minimalistic model for change detection in complex auditory environments, we designed broad-range tone clouds whose first-order statistics change at a random time. Subjects (humans or ferrets) were trained to detect these changes.They were faced with the dual-task of estimating the baseline statistics and detecting a potential change in those statistics at any moment. To characterize the extraction and encoding of relevant sensory information along the cortical hierarchy, we first recorded the brain electrical activity of human subjects engaged in this task using electroencephalography. Human performance and reaction times improved with longer pre-change exposure, consistent with improved estimation of baseline statistics. Change-locked and decision-related EEG responses were found in a centro-parietal scalp location, whose slope depended on change size, consistent with sensory evidence accumulation. To further this investigation, we performed a series of electrophysiological recordings in the primary auditory cortex (A1), secondary auditory cortex (PEG) and frontal cortex (FC) of the fully trained behaving ferret. A1 neurons exhibited strong onset responses and change-related discharges specific to neuronal tuning. PEG population showed reduced onset-related responses, but more categorical change-related modulations. Finally, a subset of FC neurons (dlPFC/premotor) presented a generalized response to all change-related events only during behavior. We show using a Generalized Linear Model (GLM) that the same subpopulation in FC encodes sensory and decision signals, suggesting that FC neurons could operate conversion of sensory evidence to perceptual decision. All together, these area-specific responses suggest a behavior-dependent mechanism of sensory extraction and generalization of task-relevant event. Aleksandar Ivanov Title: How does the auditory system adapt to different environments: A song of echoes and adaptation", "hosted_by": "Cortex Club", "domain": ["Neuroscience"], "calendar_event_hash": "1e518a07c9eb41ab6c412a1f95347fb5b6f9d6c7fbb32a366f3f47e9bfe09884", "seminar_id": 346, "time_of_addition": "Tue, Jul 07, 2020 22:30"}, "344": {"seminar_date": "Thu, Jul 23, 2020", "seminar_time": "17:30", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://cortexclub.com/event/how-sleep-remodels-the-brain/", "password": "", "video_on_demand": "", "speaker_title": "Prof.", "seminar_speaker": "Gina Poe", "speaker_affil": "University of California, Los Angeles", "speaker_twitter": "@doctorpoe", "speaker_website": "https://www.ibp.ucla.edu/faculty/gina-poe/", "topic_tags": "sleep, memory, plasticity", "seminar_title": "How sleep remodels the brain", "seminar_abstract": "50 years ago it was found that sleep somehow made memories better and more permanent, but neither sleep nor memory researchers knew enough about sleep and memory to devise robust, effective tests. Today the fields of sleep and memory have grown and what is now understood is astounding. Still, great mysteries remain. What is the functional difference between the subtly different slow oscillation vs the slow wave of sleep and do they really have opposite memory consolidation effects? How do short spindles (e.g. <0.5 s as in schizophrenia) differ in function from longer ones and are longer spindles key to integrating new memories with old? Is the nesting of slow oscillations together with sleep spindles and hippocampal ripples necessary? What happens if all else is fine but the neurochemical environment is altered? Does sleep become maladaptive and \u201ccement\u201d memories into the hippocampal warehouse where they are assembled, together with all of their emotional baggage? Does maladaptive sleep underlie post-traumatic stress disorder and other stress-related disorders?  How do we optimize sleep characteristics for top emotional and cognitive function? State of the art findings and current hypotheses will be presented.", "hosted_by": "Cortex Club", "domain": ["Neuroscience"], "calendar_event_hash": "6994bf34e286826f409528e1da057c99b255f4808861a19c0b1a01ceebc1a9e2", "seminar_id": 344, "time_of_addition": "Tue, Jul 07, 2020 19:45"}, "404": {"seminar_date": "Fri, Jul 31, 2020", "seminar_time": "16:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://cortexclub.com/event/growing-up-in-science-oxford/", "password": "", "video_on_demand": "https://youtu.be/nvrPppepofY", "speaker_title": "Dr", "seminar_speaker": "Andre Marques-Smith", "speaker_affil": "CoMind", "speaker_twitter": "@TheFrontalLobe_", "speaker_website": "https://andremarques-smith.com", "topic_tags": "phd, academia, science", "seminar_title": "Growing up in Science", "seminar_abstract": "Have you ever wondered what your advisor struggled with as a graduate student? What they struggle with now?\nGrowing up in science is a conversation series featuring personal narratives of becoming and being a scientist, with a focus on the unspoken challenges of a life in science. Growing up in Science was started in 2014 at New York University and is now worldwide. This article describes the origin and impact of the series.\nAt a typical Growing up in Science event, one faculty member shares their life story, with a focus on struggles, failures, doubts, detours, and weaknesses. Common topics include dealing with expectations, impostor syndrome, procrastination, luck, rejection, conflicts with advisors, and work-life balance, life outside academia but these topics are always embedded in the speaker\u2019s broader narrative.\n\nCortex Club is hosting its first Growing up in science event!\n\nJoin us on Friday the 31st July at 4pm for hearing the unofficial story of Dr Andr\u00e9 Marques-Smith, computational neuroscientist at CoMind (read his official and unofficial story at https://cortexclub.com/event/growing-up-in-science-oxford/).\nDetails to join the talk will be circulated via the mailing list (to join our mailing list, follow the instructions at https://cortexclub.com/join-us/).", "hosted_by": "Cortex Club", "domain": ["Neuroscience"], "calendar_event_hash": "1792ab6fde760ec6ed24b94c392d4a385db0be36b98daacfd9e20e3170a33c48", "seminar_id": 404, "time_of_addition": "Sat, Jul 25, 2020 16:05"}, "723": {"seminar_date": "Wed, Aug 19, 2020", "seminar_time": "17:00", "timezone": "America/Montevideo", "posted": "yes", "seminar_link": "https://meet.google.com/zqq-iejt-bqh", "password": "", "video_on_demand": "https://drive.google.com/drive/folders/0BwuhLPLckTh4flRfbUtzTzMyQjVmdUJJb3BEcGZ5UmFKeWJ6amNJd012cnRiQXBiQ2xKWXM?usp=sharing", "speaker_title": "PhD", "seminar_speaker": "Mar\u00eda E. Castello", "speaker_affil": "Desarrollo y Evoluci\u00f3n Neural, Instituto de Investigaciones Biol\u00f3gicas Clemente Estable, MEC, Montevideo, Uruguay", "speaker_twitter": "@MaritaCastell\u00f3", "speaker_website": "http://www.iibce.edu.uy/EVONEURAL/index.html", "topic_tags": "development, evolution", "seminar_title": "Virtual Workshop Presentation", "seminar_abstract": "", "hosted_by": "IIBCE on Brain Science", "domain": ["Neuroscience"], "calendar_event_hash": "f2712b3af620a9b76e8d3a568b8008784a11e9acc44faaebdf44e3f9b0d173b0", "seminar_id": 723, "time_of_addition": "Tue, Sep 22, 2020 11:55"}, "724": {"seminar_date": "Wed, Aug 19, 2020", "seminar_time": "17:15", "timezone": "America/Montevideo", "posted": "yes", "seminar_link": "https://meet.google.com/zqq-iejt-bqh", "password": "", "video_on_demand": "https://drive.google.com/drive/folders/0BwuhLPLckTh4flRfbUtzTzMyQjVmdUJJb3BEcGZ5UmFKeWJ6amNJd012cnRiQXBiQ2xKWXM?usp=sharing", "speaker_title": "PhD", "seminar_speaker": "Juan F. Montiel", "speaker_affil": "Center for Biomedical Research, Faculty of Medicine, Universidad Diego Portales, Santiago, Chile", "speaker_twitter": "@neuroevodevo", "speaker_website": "", "topic_tags": "development, evolution", "seminar_title": "How brain evolutionary mechanisms could inspire AI structural designs", "seminar_abstract": "Across evolution and, in particular, in brain evolutionary development we can observe how diverse adaptive biological mechanisms are displayed as a solution to environmental demands. In this talk, I will discuss some examples of emerging evolutionary developmental strategies allowing to increase brain computational capacities and how neurodevelopmental conservation, divergence, and convergence would inspire AI systems optimization.", "hosted_by": "IIBCE on Brain Science", "domain": ["Neuroscience"], "calendar_event_hash": "f03bf35490661902de02cfa5e72663db3915f6bfae3ed7ce3e4c3cffc49359c7", "seminar_id": 724, "time_of_addition": "Tue, Sep 22, 2020 11:55"}, "725": {"seminar_date": "Wed, Aug 19, 2020", "seminar_time": "18:15 PM", "timezone": "America/Montevideo", "posted": "yes", "seminar_link": "https://meet.google.com/zqq-iejt-bqh", "password": "", "video_on_demand": "https://drive.google.com/drive/folders/0BwuhLPLckTh4flRfbUtzTzMyQjVmdUJJb3BEcGZ5UmFKeWJ6amNJd012cnRiQXBiQ2xKWXM?usp=sharing", "speaker_title": "Engineer", "seminar_speaker": "Pamela Guevara", "speaker_affil": "Department of Electrical Engineering, Faculty of Engineering, Universidad de Concepci\u00f3n, Chile", "speaker_twitter": "@pameguesa", "speaker_website": "https://pamelaguevara.icb.udec.cl/en/home/", "topic_tags": "", "seminar_title": "Machine learning methods applied to dMRI tractography for the study of brain connectivity", "seminar_abstract": "Tractography datasets, calculated from dMRI, represent the main WM structural connections in the brain. Thanks to advances in image acquisition and processing, the complexity and size of these datasets have constantly increased, also containing a large amount of artifacts. We present some examples of algorithms, most of them based on classical machine learning approaches, to analyze these data and identify common connectivity patterns among subjects.", "hosted_by": "IIBCE on Brain Science", "domain": ["Neuroscience"], "calendar_event_hash": "16635ab65941f8266c7d3ecf7fba57168cb0405c473b0357e31db1f896107c77", "seminar_id": 725, "time_of_addition": "Tue, Sep 22, 2020 11:55"}, "726": {"seminar_date": "Wed, Aug 19, 2020", "seminar_time": "19:15 PM", "timezone": "America/Montevideo", "posted": "yes", "seminar_link": "https://meet.google.com/cex-afsj-rbk", "password": "", "video_on_demand": "https://drive.google.com/drive/folders/0BwuhLPLckTh4flRfbUtzTzMyQjVmdUJJb3BEcGZ5UmFKeWJ6amNJd012cnRiQXBiQ2xKWXM?usp=sharing", "speaker_title": "PhD, Director of research", "seminar_speaker": "Roberto Toro", "speaker_affil": "Department of Neuroscience, Institut Pasteur, Paris, France", "speaker_twitter": "@R3RTO", "speaker_website": "https://research.pasteur.fr/en/member/roberto-toro/", "topic_tags": "development, evolution, computational neuroanatomy, genomics, neuroimaging, modelling", "seminar_title": "Role of mechanical morphogenesis in the development and evolution of the cerebral cortex", "seminar_abstract": "", "hosted_by": "IIBCE on Brain Science", "domain": ["Neuroscience"], "calendar_event_hash": "a45f0e98f3c0e249801a6986fc4f88dc5520863fed774a4f5659e2ab046a2ed7", "seminar_id": 726, "time_of_addition": "Tue, Sep 22, 2020 11:55"}, "727": {"seminar_date": "Wed, Aug 19, 2020", "seminar_time": "20:15 PM", "timezone": "America/Montevideo", "posted": "yes", "seminar_link": "https://meet.google.com/cex-afsj-rbk", "password": "", "video_on_demand": "https://drive.google.com/drive/folders/0BwuhLPLckTh4flRfbUtzTzMyQjVmdUJJb3BEcGZ5UmFKeWJ6amNJd012cnRiQXBiQ2xKWXM?usp=sharing", "speaker_title": "PhD", "seminar_speaker": "\u00c1ngel Caputi", "speaker_affil": "Neurociencias Integrativas y Computacionales, Instituto de Investigaciones Biol\u00f3gicas Clemente Estable, MEC, Montevideo, Uruguay", "speaker_twitter": "", "speaker_website": "http://www.iibce.edu.uy/UNIC/", "topic_tags": "", "seminar_title": "Getting to no, is there a brain denying function?", "seminar_abstract": "", "hosted_by": "IIBCE on Brain Science", "domain": ["Neuroscience"], "calendar_event_hash": "7894bc54e9d6afe67a6c508ba6363ddaf6004256d44fe25b49ef116b5a4b3df8", "seminar_id": 727, "time_of_addition": "Tue, Sep 22, 2020 11:55"}, "728": {"seminar_date": "Thu, Aug 20, 2020", "seminar_time": "16:50", "timezone": "America/Montevideo", "posted": "yes", "seminar_link": "https://docs.google.com/forms/d/15NMlfxjgiz0c3sP4pjjRPeTEV_qskUJBoaTq0tfNbLE/edit#responses", "password": "", "video_on_demand": "https://us02web.zoom.us/j/84881580281?pwd=WlUwQnc0WCswUGhldGxHUncvbnhoQT09", "speaker_title": "MSc student:Clinical Child and Adolescent Psychology", "seminar_speaker": "Adalena De Le\u00f3n,", "speaker_affil": "Universidad Santa Mar\u00eda La Antigua, Panama", "speaker_twitter": "", "speaker_website": "", "topic_tags": "", "seminar_title": "Student\u00b4s Oral Presentation I: Trigeminal\u00b4s olfactory evoked potentials", "seminar_abstract": "", "hosted_by": "IIBCE on Brain Science", "domain": ["Neuroscience"], "calendar_event_hash": "34b4701196847f1ea6f05038136d841f9f751202bf0b7c2e89ce7cd3cabe3d04", "seminar_id": 728, "time_of_addition": "Tue, Sep 22, 2020 11:55"}, "729": {"seminar_date": "Thu, Aug 20, 2020", "seminar_time": "17:10:00 PM", "timezone": "America/Montevideo", "posted": "yes", "seminar_link": "https://docs.google.com/forms/d/15NMlfxjgiz0c3sP4pjjRPeTEV_qskUJBoaTq0tfNbLE/edit#responses", "password": "", "video_on_demand": "https://drive.google.com/drive/folders/0BwuhLPLckTh4flRfbUtzTzMyQjVmdUJJb3BEcGZ5UmFKeWJ6amNJd012cnRiQXBiQ2xKWXM?usp=sharing", "speaker_title": "C.Alen and M Castro: Biological Sciences Secondary School Teachers;  M. Castro: Clinical Bioquemist student; A.C. Gonaz\u00e1lez:MSc student: Biological Sciences", "seminar_speaker": "Carolina Alen; Magela Castro, Ana Clara Gonz\u00e1lez, Montevideo, Uruguay", "speaker_affil": "C.Alen and M Castro: CES, ANEP; M. Castro: School of Chemistry, UdelaR; A.C.Gonaz\u00e1lez: PEDECIBA,                                  Montevideo, Uruguay", "speaker_twitter": "", "speaker_website": "", "topic_tags": "", "seminar_title": "Student\u00b4s Oral Presentation II: Comparative study of the bioelectric activity of the legs of the Blaptica dubia cockroach", "seminar_abstract": "", "hosted_by": "IIBCE on Brain Science", "domain": ["Neuroscience"], "calendar_event_hash": "e974f56e0dd316b1cd507726def4eff3abf962c4fc42266d130a4b6d2a332f46", "seminar_id": 729, "time_of_addition": "Tue, Sep 22, 2020 11:55"}, "730": {"seminar_date": "Thu, Aug 20, 2020", "seminar_time": "17:30", "timezone": "America/Montevideo", "posted": "yes", "seminar_link": "https://docs.google.com/forms/d/15NMlfxjgiz0c3sP4pjjRPeTEV_qskUJBoaTq0tfNbLE/edit#responses", "password": "", "video_on_demand": "https://drive.google.com/drive/folders/0BwuhLPLckTh4flRfbUtzTzMyQjVmdUJJb3BEcGZ5UmFKeWJ6amNJd012cnRiQXBiQ2xKWXM?usp=sharing", "speaker_title": "F. L\u00f3pez: MSc student: Cognitive Neuroscience; Rodrigo Sanz: MSc student: Cognitive Neuroscience", "seminar_speaker": "Francisco L\u00f3pez-Guzm\u00e1n & Rodrigo Sanz, Montevideo, Uruguay", "speaker_affil": "Universidad de la Rep\u00fablica, Montevideo, Uruguay", "speaker_twitter": "", "speaker_website": "", "topic_tags": "", "seminar_title": "Student\u00b4s Oral Presentation III: Emotional State Classification Using Low-Cost Single-Channel Electroencephalography", "seminar_abstract": "Although electroencephalography (EEG) has been used in clinical and research studies for almost a century, recent technological advances have made the equipment and processing tools more accessible outside laboratory settings. These low-cost alternatives can achieve satisfactory results in experiments such as detecting event-related potentials and classifying cognitive states. In our research, we use low-cost single-channel EEG to classify brain activity during the presentation of images of opposite emotional valence from the OASIS database. Emotional classification has already been achieved using research-grade and commercial-grade equipment, but our approach pioneers the use of educational-grade equipment for said task. EEG data is collected with a Backyard Brains SpikerBox, a low-cost and open-source bioamplifier that can record a single-channel electric signal from a pair of electrodes placed on the scalp, and used to train machine learning classifiers.", "hosted_by": "IIBCE on Brain Science", "domain": ["Neuroscience"], "calendar_event_hash": "21467031051f57a2abe75888c35a581eb8aad3059f1068bf089d6479a3ff6129", "seminar_id": 730, "time_of_addition": "Tue, Sep 22, 2020 11:55"}, "731": {"seminar_date": "Thu, Aug 20, 2020", "seminar_time": "18:00", "timezone": "America/Montevideo", "posted": "yes", "seminar_link": "https://docs.google.com/forms/d/15NMlfxjgiz0c3sP4pjjRPeTEV_qskUJBoaTq0tfNbLE/edit#responses", "password": "", "video_on_demand": "https://drive.google.com/drive/folders/0BwuhLPLckTh4flRfbUtzTzMyQjVmdUJJb3BEcGZ5UmFKeWJ6amNJd012cnRiQXBiQ2xKWXM?usp=sharing", "speaker_title": "PhD", "seminar_speaker": "Gregory J. Gage, Ph.D.", "speaker_affil": "CEO, Backyard Brains", "speaker_twitter": "@BackyardBrains", "speaker_website": "https://www.ted.com/speakers/greg_gage; https://backyardbrains.com/", "topic_tags": "", "seminar_title": "Neuroscience tools for the 99%: On the low-fi development of high-tech lab gear for hands-on neuroscience labs and exploratory research", "seminar_abstract": "The public has a fascination with the brain, but little attention is given to neuroscience education prior to graduate studies in brain-related fields. One reason may be the lack of low cost and engaging teaching materials. To address this, we have developed a suite of open-source tools which are appropriate for amateurs and for use in high school, undergraduate, and graduate level educational and research programs. This lecture will provide an overview of our mission to re-engineer research-grade lab equipment using first principles and will highlight basic principles of neuroscience in a \"DIY\" fashion: neurophysiology, functional electrical stimulation, micro-stimulation effect on animal behavior, neuropharmacology, even neuroprosthesis and optogenetics!                                                              Finally, with faculty academic positions becoming a scarce resource, I will discuss an alternative academic career path: entrepreneurship. It is possible to be an academic, do research, publish papers, present at conferences and train students all outside the traditional university setting. I will close by discussing my career path from graduate student to PI/CEO of a startup neuroscience company.", "hosted_by": "IIBCE on Brain Science", "domain": ["Neuroscience"], "calendar_event_hash": "476fdad14aa3a4b3ad982c040f71bfe80c4f53e6e460e551bd8d123e511f9678", "seminar_id": 731, "time_of_addition": "Tue, Sep 22, 2020 11:55"}, "732": {"seminar_date": "Thu, Aug 20, 2020", "seminar_time": "19:00", "timezone": "America/Montevideo", "posted": "yes", "seminar_link": "https://docs.google.com/forms/d/15NMlfxjgiz0c3sP4pjjRPeTEV_qskUJBoaTq0tfNbLE/edit#responses", "password": "", "video_on_demand": "https://drive.google.com/drive/folders/0BwuhLPLckTh4flRfbUtzTzMyQjVmdUJJb3BEcGZ5UmFKeWJ6amNJd012cnRiQXBiQ2xKWXM?usp=sharing", "speaker_title": "MSc", "seminar_speaker": "Elizabeth Morosi, Montevideo, Uruguay", "speaker_affil": "", "speaker_twitter": "", "speaker_website": "", "topic_tags": "", "seminar_title": "Students\u00b4Poster Presentation I Evaluation of the effect of different types of physical training on cognitive stress caused by the Stroop test, using Backyard Brain technology", "seminar_abstract": "", "hosted_by": "IIBCE on Brain Science", "domain": ["Neuroscience"], "calendar_event_hash": "569801677601b262b6f8d6b9949029d994ec200318f3d7c3f8d68e946006756c", "seminar_id": 732, "time_of_addition": "Tue, Sep 22, 2020 11:55"}, "733": {"seminar_date": "Fri, Aug 21, 2020", "seminar_time": "16:00", "timezone": "America/Montevideo", "posted": "yes", "seminar_link": "https://docs.google.com/forms/d/e/1FAIpQLScWsHvlOv0_ZwesseXMtfwcmQW6I6bbubDnKKld3D55uEalsA/viewform?usp=pp_url", "password": "", "video_on_demand": "https://drive.google.com/drive/folders/0BwuhLPLckTh4flRfbUtzTzMyQjVmdUJJb3BEcGZ5UmFKeWJ6amNJd012cnRiQXBiQ2xKWXM?usp=sharing", "speaker_title": "MBA, MA: Education", "seminar_speaker": "\u00c1lvaro F\u00e9rnandez", "speaker_affil": "CEO, SharpBrains, San Francisco, CA, USA.", "speaker_twitter": "@AlvaroF", "speaker_website": "https://sharpbrains.com/the-team/", "topic_tags": "", "seminar_title": "C\u00f3mo invertir en nuestros cerebros y mentes a trav\u00e9s de la Inteligencia Artificial y las Neurociencias", "seminar_abstract": "", "hosted_by": "IIBCE on Brain Science", "domain": ["Neuroscience"], "calendar_event_hash": "32311685f548f4b07f1712e7a887cd1d4498a7bb5630799d03bd0972dc0720e8", "seminar_id": 733, "time_of_addition": "Tue, Sep 22, 2020 11:55"}, "734": {"seminar_date": "Fri, Aug 21, 2020", "seminar_time": "17:00", "timezone": "America/Montevideo", "posted": "yes", "seminar_link": "https://docs.google.com/forms/d/e/1FAIpQLScWsHvlOv0_ZwesseXMtfwcmQW6I6bbubDnKKld3D55uEalsA/viewform?usp=pp_url", "password": "", "video_on_demand": "https://drive.google.com/drive/folders/0BwuhLPLckTh4flRfbUtzTzMyQjVmdUJJb3BEcGZ5UmFKeWJ6amNJd012cnRiQXBiQ2xKWXM?usp=sharing", "speaker_title": "PhD Student", "seminar_speaker": "Julieta Arancio", "speaker_affil": "Centro de Investigaciones para la Transformaci\u00f3n (CENIT-UNSAM), AR", "speaker_twitter": "@Cassandreces", "speaker_website": "https://julieta.aranc.io", "topic_tags": "", "seminar_title": "Panorama de tecnolog\u00edas abiertas para ciencia y educaci\u00f3n en Am\u00e9rica Latina", "seminar_abstract": "Open science hardware (OSH) as a concept usually refers to artifacts, but also to a practice, a discipline and a collective of people pushing for open access to the design of science tools. Since 2016, the Global Open Science Hardware (GOSH) movement gathers actors from academia, education, the private sector and civic organisations to advocate for OSH to be ubiquitous by 2025. In Latin America, GOSH advocates have fundraised and gathered around the development of annual \"residencies\" for building hardware for science and education. The community is currently defining its regional strategy and identifying other regional actors working on science and technology democratization. In this presentation I will give an overview of the open hardware movement for science, with a focus on the activities and strategy of the Latin American chapter and concrete ways to engage.", "hosted_by": "IIBCE on Brain Science", "domain": ["Neuroscience"], "calendar_event_hash": "a036a0caebbd75d0120cad825cfe2b3e79df64d65f8b1c40ea44977bec146ea5", "seminar_id": 734, "time_of_addition": "Tue, Sep 22, 2020 11:55"}, "735": {"seminar_date": "Fri, Aug 21, 2020", "seminar_time": "17:45", "timezone": "America/Montevideo", "posted": "yes", "seminar_link": "https://docs.google.com/forms/d/e/1FAIpQLScWsHvlOv0_ZwesseXMtfwcmQW6I6bbubDnKKld3D55uEalsA/viewform?usp=pp_url", "password": "", "video_on_demand": "https://drive.google.com/drive/folders/0BwuhLPLckTh4flRfbUtzTzMyQjVmdUJJb3BEcGZ5UmFKeWJ6amNJd012cnRiQXBiQ2xKWXM?usp=sharing", "speaker_title": "", "seminar_speaker": "Carlos A. Almenara", "speaker_affil": "Universidad Peruana de Ciencias Aplicadas Cybermind Lab", "speaker_twitter": "", "speaker_website": "https://cybermind.ai", "topic_tags": "", "seminar_title": "Experiencias de fomento de la investigaci\u00f3n en ciberpsicolog\u00eda y neurociencias con hardware abierto: El caso de Cybermind Lab en Per\u00fa", "seminar_abstract": "", "hosted_by": "IIBCE on Brain Science", "domain": ["Neuroscience"], "calendar_event_hash": "941605de353f73b5821c05a1309c143c8157ff474b7547d137bdbccbde845e8b", "seminar_id": 735, "time_of_addition": "Tue, Sep 22, 2020 11:55"}, "736": {"seminar_date": "Mon, Sep 21, 2020", "seminar_time": "9:00", "timezone": "America/Montevideo", "posted": "yes", "seminar_link": "https://us02web.zoom.us/meeting/register/tZYlceGrrz8iE9Kmxvgx0CGLI9YddbtggS53", "password": "", "video_on_demand": "https://youtu.be/8KhSmaOImEY", "speaker_title": "Professor", "seminar_speaker": "Carlos Belmonte", "speaker_affil": "Real Academia Espa\u00f1ola de Ciencias Exactas, F\u00edsicas y Naturales", "speaker_twitter": "", "speaker_website": "https://rac.es/sobre-nosotros/miembros/academicos/numerarios/27/", "topic_tags": "Spanish \ud83d\udde3\ufe0f, cerebro, conducta humana, inteligencia artificial", "seminar_title": "La investigaci\u00f3n del cerebro: Esperanzas e incertidumbres", "seminar_abstract": "Esta conferencia pretende ofrecer una visi\u00f3n panor\u00e1mica de los progresos en el conocimiento del cerebro, desde la fundaci\u00f3n por Cajal de la moderna neurociencia hasta los muy recientes hallazgos aportados por la gen\u00e9tica, la biolog\u00eda molecular, la microscopia y la electrofisiolog\u00eda al conocimiento de la estructura, conectividad y funci\u00f3n de las c\u00e9lulas nerviosas, asi como sobre el funcionamiento integrado del cerebro humano aportado por las nuevas t\u00e9cnicas de imagen y el registro y estimulaci\u00f3n selectivos de las distintas \u00e1reas cerebrales y su an\u00e1lisis con t\u00e9cnicas de computaci\u00f3n. Finalmente se discutir\u00e1n las repercusiones m\u00e9dicas y sociales que implica un mejor conocimiento del cerebro, sus limitaciones en el momento actual y los riesgo que conlleva el mal uso de los avances cient\u00edficos de la neurociencia.", "hosted_by": "IIBCE on Brain Science", "domain": ["Neuroscience"], "calendar_event_hash": "a01f8e7db6ffd039881836ef75e5b11ef7c35aeddca9bb35e0665a250bb8d19b", "seminar_id": 736, "time_of_addition": "Tue, Sep 22, 2020 11:55"}, "746": {"seminar_date": "Mon, Sep 28, 2020", "seminar_time": "9:00", "timezone": "America/Montevideo", "posted": "yes", "seminar_link": "https://us02web.zoom.us/j/88952462697?pwd=NHJzUndKQU1QRDVwMFhNWkRQcU5UZz09", "password": "", "video_on_demand": "https://youtu.be/pPwBjIZf8bk", "speaker_title": "Professor", "seminar_speaker": "Eve Marder, Ph.D.", "speaker_affil": "Victor and Gwendolyn Beinfield Professor of Neuroscience,  Biology Dept and Volen Center, \nBrandeis University, Waltham, MA, USA", "speaker_twitter": "@MarderLab", "speaker_website": "https://blogs.brandeis.edu/marderlab/", "topic_tags": "neuronal properties, resilience, stomatogastric nervous system, Spanish \ud83d\udde3\ufe0f", "seminar_title": "Differential Resilience of Neurons and Networks with Similar Behavior to Perturbation. (Simultaneous translation to Spanish)", "seminar_abstract": "Both computational and experimental results in single neurons and small networks demonstrate that very similar network function can result from quite disparate sets of neuronal and network parameters. Using the crustacean stomatogastric nervous system, we study the influence of these differences in underlying structure on differential resilience of individuals to a variety of environmental perturbations, including changes in temperature, pH, potassium concentration and neuromodulation. We show that neurons with many different kinds of ion channels can smoothly move through different mechanisms in generating their activity patterns, thus extending their dynamic range. The talk will be simultaneously translated to spanish by the interpreter Liliana Viera, MSc.                                                                                                                                                                           Los resultados tanto computacionales como experimentales en neuronas individuales y redes peque\u00f1as demuestran que funcionamientos de redes muy similares pueden pueden resultar de conjuntos bastante dispares de par\u00e1metros neuronales y de las redes. Utilizando el sistema nervioso estomatog\u00e1strico de los crust\u00e1ceos, estudiamos la influencia de estas diferencias en la estructura subyacente en la resistencia diferencial de los individuos a una variedad de perturbaciones ambientales, incluidos los cambios de temperatura, pH, concentraci\u00f3n de potasio y neuromodulaci\u00f3n. Mostramos que neuronas con muchos tipos diferentes de canales i\u00f3nicos pueden moverse suavemente a trav\u00e9s de diferentes mecanismos para generar sus patrones de actividad, extendiendo as\u00ed su rango din\u00e1mico. La conferencia ser\u00e1 traducida simult\u00e1neamente al espa\u00f1ol por la int\u00e9rprete Liliana Viera MSc.", "hosted_by": "IIBCE on Brain Science", "domain": ["Neuroscience"], "calendar_event_hash": "0ebeb805b9515cfdbd561a8cbe3bb3a8a196565bd4604692191fb4957723d98d", "seminar_id": 746, "time_of_addition": "Thu, Sep 24, 2020 01:15"}, "1050": {"seminar_date": "Mon, Oct 12, 2020", "seminar_time": "9:00", "timezone": "America/Montevideo", "posted": "yes", "seminar_link": "https://us02web.zoom.us/j/82868314896?pwd=UXNVbWxmTzk2eDJTNDFjeVZmQTRXQT09", "password": "", "video_on_demand": "https://drive.google.com/drive/folders/1Rhjy_ok2yxeecHRzBdcgWObK8r4fZdm0?usp=sharing", "speaker_title": "Professor", "seminar_speaker": "Ed Boyden", "speaker_affil": "Y. Eva Tan Professor in Neurotechnology at MIT; Howard Hughes Medical Institute; McGovern Institute; Professor, Departments of Brain and Cognitive Sciences, Media Arts and Sciences, and Biological Engineering; Co-Director, MIT Center for Neurobiological Engineering; Member, MIT Center for Environmental Health Sciences, Computational and Systems Biology Initiative, and Koch Institute; Leader, Synthetic Neurobiology Group, Massachusetts Institute of Technology", "speaker_twitter": "@eboyden3", "speaker_website": "http://syntheticneurobiology.org/people/display/71/11", "topic_tags": "Spanish \ud83d\udde3\ufe0f, brain structural organization, expansion microscopy, optogenetics, fluorescent voltage indicators", "seminar_title": "Tools for Analyzing and Repairing the Brain. ( (Simultaneous translation to Spanish))", "seminar_abstract": "To enable the understanding and repair of complex biological systems, such as the brain, we are creating novel optical tools that enable molecular-resolution maps of such systems, as well as technologies for observing and controlling high-speed physiological dynamics in such systems. First, we have developed a method for imaging specimens with nanoscale precision, by embedding them in a swellable polymer, homogenizing their mechanical properties, and exposing them to water \u2013 which causes them to expand manyfold isotropically. This method, which we call expansion microscopy (ExM), enables ordinary microscopes to do nanoscale imaging, in a multiplexed fashion \u2013 important, for example, for brain mapping. Second, we have developed a set of genetically-encoded reagents, known as optogenetic tools, that when expressed in specific neurons, enable their electrical activities to be precisely driven or silenced in response to millisecond timescale pulses of light. Finally, we are designing, and evolving, novel reagents, such as fluorescent voltage indicators and somatically targeted calcium indicators, to enable the imaging of fast physiological processes in 3-D with millisecond precision. In this way we aim to enable the systematic mapping, control, and dynamical observation of complex biological systems like the brain.  The talk will be simultaneously interpreted  English-Spanish) by the Interpreter, MSc. Liliana Viera.                                                         Para permitir la comprensi\u00f3n y reparaci\u00f3n de sistemas biol\u00f3gicos complejos, como el cerebro, estamos creando herramientas \u00f3pticas novedosas que permiten crear mapas de resoluci\u00f3n molecular de dichos sistemas, as\u00ed como tecnolog\u00edas para observar y controlar la din\u00e1mica fisiol\u00f3gica de alta velocidad en dichos sistemas. Primero, hemos desarrollado un m\u00e9todo para obtener im\u00e1genes de muestras con precisi\u00f3n a nanoescala, incrust\u00e1ndolas en un pol\u00edmero hinchable, homogeneizando sus propiedades mec\u00e1nicas y exponi\u00e9ndolas al agua, lo que hace que se expandan muchas veces isotr\u00f3picamente. Este m\u00e9todo, que llamamos microscop\u00eda de expansi\u00f3n (ExM), permite que los microscopios ordinarios obtengan im\u00e1genes a nanoescala, de forma multiplexada, lo que es importante, por ejemplo, para el mapeo cerebral. En segundo lugar, hemos desarrollado un conjunto de reactivos codificados gen\u00e9ticamente, conocidos como herramientas optogen\u00e9ticas, que cuando se expresan en neuronas espec\u00edficas, permiten que sus actividades el\u00e9ctricas sean activadas o silenciadas con precisi\u00f3n en respuesta a pulsos de luz en una escala de tiempo de milisegundos. Finalmente, estamos dise\u00f1ando y desarrollando reactivos novedosos, como indicadores de voltaje fluorescentes e indicadores de calcio dirigidos som\u00e1ticamente, para permitir la obtenci\u00f3n de im\u00e1genes de procesos fisiol\u00f3gicos r\u00e1pidos en 3-D con precisi\u00f3n de milisegundos. De esta manera, nuestro objetivo es permitir el mapeo sistem\u00e1tico, el control y la observaci\u00f3n din\u00e1mica de sistemas biol\u00f3gicos complejos como el cerebro. La conferencia ser\u00e1 traducida simult\u00e1neamente al espa\u00f1ol por la int\u00e9rprete Liliana Viera MSc.", "hosted_by": "IIBCE on Brain Science", "domain": ["Neuroscience"], "calendar_event_hash": "8a3ae9cf2908ee54f64c80a11528e0a8595bc417289d7a9ce8f3dcbfd50cede1", "seminar_id": 1050, "time_of_addition": "Thu, Oct 01, 2020 00:20"}, "937": {"seminar_date": "Mon, Sep 28, 2020", "seminar_time": "16:30", "timezone": "Europe/Zurich", "posted": "yes", "seminar_link": "https://unil.zoom.us/j/94071898638", "password": "645866", "video_on_demand": "", "speaker_title": "Dr", "seminar_speaker": "Giuseppe Caruso", "speaker_affil": "Department of Drug Sciences, University of Catania", "speaker_twitter": "", "speaker_website": "", "topic_tags": "depression, memory, Alzheimer's", "seminar_title": "Fluoxetine and vortioxetine reverse depressive-like phenotype and memory deficits induced by amyloid-\u03b2 (1-42) oligomers in mice: implication of transforming growth factor-\u03b21 and oxidative stress", "seminar_abstract": "A long-term treatment with antidepressants reduces the risk to develop AD and different second-generation antidepressants such as selective serotonin reuptake inhibitors (SSRIs) are currently studied for their neuroprotective properties in AD. An impairment of neurotrophic factors signaling seems to be a common pathophysiological event in depression and AD. In particular a deficit of transforming growth factor-\u03b21 (TGF-\u03b21) and increased oxidative stress have been found both in depression and AD. In the present work the SSRI fluoxetine and the new multimodal antidepressant vortioxetine were tested for their ability to prevent memory deficits and depressive-like phenotype in a non-transgenic mouse model of AD (i.c.v. A\u03b21-42 injection) by rescue of TGF-\u03b21 signaling. The same drugs were also tested for their ability to modulate the expression of pro-oxidant genes as well as of genes related to the antioxidant machinery.", "hosted_by": "NeuroLeman Network", "domain": ["Neuroscience"], "calendar_event_hash": "a4308fe1deb3f9fb7116ff6bfd6b44b11f4ff9d4b54f8133d61b6b277f21592d", "seminar_id": 937, "time_of_addition": "Mon, Sep 28, 2020 13:05"}, "938": {"seminar_date": "Thu, Oct 1, 2020", "seminar_time": "14:30", "timezone": "Europe/Zurich", "posted": "yes", "seminar_link": "https://unil.zoom.us/j/98033963907", "password": "", "video_on_demand": "", "speaker_title": "Dr", "seminar_speaker": "Giuseppe Caruso", "speaker_affil": "Department of Drug Sciences, University of Catania", "speaker_twitter": "", "speaker_website": "", "topic_tags": "neuroinflammation, Alzheimer's, neuroprotection", "seminar_title": "Carnosine negatively modulates pro-oxidant activities of M1 peripheral macrophages and prevents neuroinflammation induced by amyloid-\u03b2 in microglial cells", "seminar_abstract": "Carnosine is a natural dipeptide widely distributed in mammalian tissues and exists at particularly high concentrations in skeletal and cardiac muscles and brain. A growing body of evidence shows that carnosine is involved in many cellular defense mechanisms against oxidative stress, including inhibition of amyloid-\u03b2 (A\u03b2) aggregation, modulation of nitric oxide (NO) metabolism, and scavenging both reactive nitrogen and oxygen species. Different types of cells are involved in the innate immune response, with macrophage cells representing those primarily activated, especially under different diseases characterized by oxidative stress and systemic inflammation such as depression and cardiovascular disorders. Microglia, the tissue-resident macrophages of the brain, are emerging as a central player in regulating key pathways in central nervous system inflammation; with specific regard to Alzheimer\u2019s disease (AD) these cells exert a dual role: on one hand promoting the clearance of A\u03b2 via phagocytosis, on the other hand increasing neuroinflammation through the secretion of inflammatory mediators and free radicals.\nThe activity of carnosine was tested in an in vitro model of macrophage activation (M1) (RAW 264.7 cells stimulated with LPS + IFN-\u03b3) and in a well-validated model of A\u03b2-induced neuroinflammation (BV-2 microglia treated with A\u03b2 oligomers). An ample set of techniques/assays including MTT assay, trypan\nblue exclusion test, high performance liquid chromatography, high-throughput real-time PCR, western blot, atomic force microscopy, microchip electrophoresis coupled to laser-induced fluorescence, and ELISA aimed to evaluate the antioxidant and anti-inflammatory activities of carnosine was employed.\nIn our experimental model of macrophage activation (M1), therapeutic concentrations of carnosine exerted the following effects: 1) an increased degradation rate of NO into its non-toxic end-products nitrite and nitrate; 2) the amelioration of the macrophage energy state, by restoring nucleoside triphosphates and counterbalancing the changes in ATP/ADP, NAD+/NADH and NADP+/NADPH ratio obtained by LPS + IFN-\u03b3 induction; 3) a reduced expression of pro-oxidant enzymes (NADPH oxidase, Cyclooxygenase-2) and of the lipid peroxidation product malondialdehyde; 4) the rescue of antioxidant enzymes expression (Glutathione peroxidase 1, Superoxide dismutase 2, Catalase); 5) an increased synthesis of transforming growth factor-\u03b21 (TGF-\u03b21) combined with the negative modulation of interleukines 1\u03b2 and 6 (IL-1\u03b2 and IL-6), and 6) the induction of nuclear factor erythroid-derived 2-like 2 (Nrf2) and heme oxygenase-1 (HO-1).\nIn our experimental model of A\u03b2-induced neuroinflammation, carnosine: 1) prevented cell death in BV-2 cells challenged with A\u03b2 oligomers; 2) lowered oxidative stress by decreasing the expression of inducible nitric oxide synthase and NADPH oxidase, and the concentrations of nitric oxide and superoxide anion; 3) decreased the secretion of pro-inflammatory cytokines such as IL-1\u03b2 simultaneously rescuing IL-10 levels and increasing the expression and the release of TGF-\u03b21; 4) prevented A\u03b2-induced neurodegeneration in primary mixed neuronal cultures challenged with A\u03b2 oligomers and these neuroprotective effects was completely abolished by SB431542, a selective inhibitor of type-1 TGF-\u03b2 receptor.\nOverall, our data suggest a novel multimodal mechanism of action of carnosine underlying its protective effects in macrophages and microglia and the therapeutic potential of this dipeptide in counteracting pro-oxidant and pro-inflammatory phenomena observed in different disorders characterized by elevated levels of oxidative stress and inflammation such as depression, cardiovascular disorders, and Alzheimer\u2019s disease.", "hosted_by": "NeuroLeman Network", "domain": ["Neuroscience"], "calendar_event_hash": "ab0eb0a52455e2ab769c4e3fc1bdff196d452308a3d92befcf5a7061d6f89f5a", "seminar_id": 938, "time_of_addition": "Mon, Sep 28, 2020 13:05"}, "939": {"seminar_date": "Thu, Oct 1, 2020", "seminar_time": "12:15", "timezone": "Europe/Zurich", "posted": "yes", "seminar_link": "https://unil.zoom.us/j/2636884125", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Bart De Strooper", "speaker_affil": "\"UK Dementia Research Institute, UCL, London &\nKU Leuven & VIB Center for Brain and Disease Research, Belgium\"", "speaker_twitter": "", "speaker_website": "", "topic_tags": "Alzheimer's, microglia, stem cells", "seminar_title": "The cellular phase of Alzheimer\u2019s Disease:\nfrom genes to cells", "seminar_abstract": "The amyloid cascade hypothesis for Alzheimer disease  ((Hardy and Selkoe, 2002; Hardy and Higgins, 1992; Selkoe, 1991), updated in (Karran et al., 2011) provides a linear model for the pathogenesis of AD with A\u03b2 accumulation upstream and Tau pathology, inflammation, synaptic dysfunction, neuronal loss and dementia downstream,  all interlinked, initiated and driven by A\u03b242 peptides or oligomers. The genetic mutations causing familial Alzheimer disease seem to support this model. The nagging problem remains however that the postulated causal, and especially the \u2019driving\u2019 role of abnormal A\u03b2 aggregation or A\u03b2 oligomer formation could not be convincingly demonstrated until now. Indeed, many questions (e.g. what causes A\u03b2 toxicity, what is the relation between A\u03b2 and Tau pathology, what causes neuronal death, why is amyloid deposition not correlated with dementia etc\u2026) were already raised when the amyloid hypothesis was conceived 25 years ago. These questions remain in essence unanswered. It seems that the old paradigm is not tenable: the amyloid cascade is too linear, too neurocentric, and does not take into account the long time lag between the biochemical phase i.e. the appearance of amyloid plaques and neuronal tangles and the ultimate clinical phase, i.e. the manifestation of dementia. The pathways linking these two phases must be complex and tortuous. We have called this the cellular phase of AD (De Strooper and Karran, 2016) to suggest that a long period of action and reaction involving neurons, neuronal circuitry but also microglia, astroglia, oligodendrocytes, and the vasculature underlies the disease. In fact it is this long disease process that should be studied in the coming years. While microglia are part of this process, they should not be considered as the only component of the cellular phase. We expect that further clinical investigations and novel tools will allow to diagnose the effects of the cellular changes in the brain and provide clinical signs for this so called preclinical or prodromal AD. Furthermore the better understanding of this phase will lead to completely novel drug targets and treatments and will lead to an era where patients will receive an appropriate therapy according to their clinical stage. In this view anti-amyloid therapy is probably only effective and useful in the very early stage of the disease and AD does no longer equal to dementia.  We will discuss in our talk how single cell technology and transplantation of human iPS cells into mouse brain allow to start to map in a systematic way the cellular phase of Alzheimer\u2019s Disease.", "hosted_by": "NeuroLeman Network", "domain": ["Neuroscience"], "calendar_event_hash": "27ac2e1a93ca6dd181d80344def683effb70dc67c32e7f9eb247e366df94fad0", "seminar_id": 939, "time_of_addition": "Mon, Sep 28, 2020 13:05"}, "940": {"seminar_date": "Wed, Oct 7, 2020", "seminar_time": "12:15", "timezone": "Europe/Zurich", "posted": "yes", "seminar_link": "https://memento.epfl.ch/event/bmi-seminar-webinar-patrik-verstreken-the-cellular/", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Patrik Verstreken", "speaker_affil": "\"Laboratory of Neuronal Communication, VIB, Gent, Belgium\"", "speaker_twitter": "", "speaker_website": "", "topic_tags": "PD, dopamine, stem cells", "seminar_title": "The cellular basis of Parkinson\u2019s disease", "seminar_abstract": "Parkinson\u2019s disease is affects millions of \npeople around the world.\u00a0 The disease is characterized by typical \nmovement defects that are caused by the loss of dopaminergic neurons, \nbut several very debilitating non-motor symptoms occur more than 10 \nyears before the motor symptoms.\u00a0 I will discuss how we study these \nnon-motor symptoms including sleep disturbances and olfactory defects \nusing large collections of knock in fruit flies that model the numerous \nfamilial forms of Parkinson\u2019s disease as well as using human iPS cells \nfrom patients.\u00a0 A common emerging theme are defects in protein \nhomeostasis that in specific neuronal cell types, cause cellular defects\n that explain the Parkinson-relevant phenotypes.\u00a0 Our work reveals the \nmechanisms that cause early defects in Parkinson\u2019s disease and it opens \ntherapeutic avenues to start tackling this disease.", "hosted_by": "NeuroLeman Network", "domain": ["Neuroscience"], "calendar_event_hash": "fbf978a5119ee3d0b7cb20407d77b6395874b60dc743550ad0d2a75253ebd391", "seminar_id": 940, "time_of_addition": "Mon, Sep 28, 2020 13:05"}, "592": {"seminar_date": "Tue, Sep 8, 2020", "seminar_time": "15:00", "timezone": "Europe/Paris", "posted": "yes", "seminar_link": "https://us02web.zoom.us/webinar/register/WN_oOsgcq-uT8aBwNdUoIM7OQ", "password": "", "video_on_demand": "http://www.ern-rnd.eu/education-training/past-webinars/", "speaker_title": "", "seminar_speaker": "Robert Rusina & Zsolt Cs\u00e9falvay", "speaker_affil": "Charles University Thomayer Hospital & Comenius University, Czech Republic", "speaker_twitter": "@ERN_RND", "speaker_website": "", "topic_tags": "neurology, frontotemporal dementia, dementia, aphasia, rare diseases", "seminar_title": "Semantic variant of primary progressive aphasia, clinical manifestation and underlying neuropathology", "seminar_abstract": "", "hosted_by": "ERN-RND", "domain": ["Neuroscience"], "calendar_event_hash": "61b050ae4c01b06dc8c926e4796746380dde546e4b7dba9ac2926d5e1ae9e15b", "seminar_id": 592, "time_of_addition": "Mon, Sep 07, 2020 15:20"}, "624": {"seminar_date": "Thu, Sep 10, 2020", "seminar_time": "15:00", "timezone": "Europe/Paris", "posted": "yes", "seminar_link": "https://bit.ly/3m0bBym", "password": "", "video_on_demand": "http://www.ern-rnd.eu/education-training/past-webinars/", "speaker_title": "", "seminar_speaker": "G\u00e1l Ota", "speaker_affil": "General University Hospital in Prague, Czech Republic", "speaker_twitter": "@ERN_RND", "speaker_website": "", "topic_tags": "neurology, rare diseases, adrenoleukodystrophy, spastic paresis", "seminar_title": "How to assess and manage spastic gait in rare diseases?", "seminar_abstract": "", "hosted_by": "ERN-RND", "domain": ["Neuroscience"], "calendar_event_hash": "42cb96026f4900e1264e8445f973f59e737f0d0d9b19eb46f0196db36585655c", "seminar_id": 624, "time_of_addition": "Tue, Sep 08, 2020 12:25"}, "625": {"seminar_date": "Tue, Sep 15, 2020", "seminar_time": "15:00", "timezone": "Europe/Paris", "posted": "yes", "seminar_link": "https://bit.ly/33nkutt", "password": "", "video_on_demand": "http://www.ern-rnd.eu/education-training/past-webinars/", "speaker_title": "", "seminar_speaker": "Ferdinando Squitieri", "speaker_affil": "Fondazione IRCCS Casa Sollievo Sofferenza & CSS-Mendel Institute, Italy", "speaker_twitter": "@ERN_RND", "speaker_website": "", "topic_tags": "neurology, Huntington's Disease, paediatric, neurogenetics, rare diseases", "seminar_title": "A challenge in neurogenetics: Huntington disease in kids", "seminar_abstract": "", "hosted_by": "ERN-RND", "domain": ["Neuroscience"], "calendar_event_hash": "1bfc34f8a198ddd8a31fbeddbe1b8669aa5a9e7e4da640fcc76904dd9587c84d", "seminar_id": 625, "time_of_addition": "Tue, Sep 08, 2020 12:30"}, "626": {"seminar_date": "Tue, Sep 29, 2020", "seminar_time": "15:00", "timezone": "Europe/Paris", "posted": "yes", "seminar_link": "https://bit.ly/33nkutt", "password": "", "video_on_demand": "http://www.ern-rnd.eu/education-training/past-webinars/", "speaker_title": "", "seminar_speaker": "Hortensia Gimeno", "speaker_affil": "NIHR & Guy's and St Thomas' NHS Foundation Trust, UK", "speaker_twitter": "@HortensiaGimeno", "speaker_website": "www.ern-rnd.eu/education-training/webinars/", "topic_tags": "rehabilitation, rare diseases", "seminar_title": "How can we develop and implement evidence based rehabilitation in rare disorders?", "seminar_abstract": "", "hosted_by": "ERN-RND", "domain": ["Neuroscience"], "calendar_event_hash": "ffbe38b4fc64072c877f4efb9eab5f496f8a751a1f107d3b27d65b3a4b9f8518", "seminar_id": 626, "time_of_addition": "Tue, Sep 08, 2020 12:30"}, "627": {"seminar_date": "Thu, Oct 1, 2020", "seminar_time": "15:00", "timezone": "Europe/Paris", "posted": "yes", "seminar_link": "https://bit.ly/3275r7u", "password": "", "video_on_demand": "http://www.ern-rnd.eu/education-training/past-webinars/", "speaker_title": "", "seminar_speaker": "Rebecca Sch\u00fcle", "speaker_affil": "University of T\u00fcbingen, Germany", "speaker_twitter": "@uktuebingen", "speaker_website": "www.ern-rnd.eu/education-training/webinars/", "topic_tags": "neurology, hereditary spastic paraplegia, movement disorders, rare diseases", "seminar_title": "Hereditary Spastic Paraplegia (HSP): clinical disease course", "seminar_abstract": "", "hosted_by": "ERN-RND", "domain": ["Neuroscience"], "calendar_event_hash": "c91891a43985523030601908f70e676edab631367d00ab54b2bc53c918ed0357", "seminar_id": 627, "time_of_addition": "Tue, Sep 08, 2020 12:30"}, "1158": {"seminar_date": "Tue, Oct 6, 2020", "seminar_time": "15:00", "timezone": "Europe/Paris", "posted": "yes", "seminar_link": "https://bit.ly/3275r7u", "password": "", "video_on_demand": "http://www.ern-rnd.eu/education-training/past-webinars/", "speaker_title": "", "seminar_speaker": "Annemieke Buizer", "speaker_affil": "Amsterdam Research Institute for Movement Sciences & Amsterdam University Medical Center, Netherlands", "speaker_twitter": "@AnnemiekeBU @ERN_RND", "speaker_website": "www.ern-rnd.eu/education-training/webinars/", "topic_tags": "neurorehabilitation, neurology, rare diseases", "seminar_title": "Treatment of spasticity in HSP and leukodystrophies", "seminar_abstract": "", "hosted_by": "ERN-RND", "domain": ["Neuroscience"], "calendar_event_hash": "4b5e40776e3be2cf0111ed95998c163e193de9c7a52e2d0cb52cbff5c10c7aaa", "seminar_id": 1158, "time_of_addition": "Mon, Oct 05, 2020 19:30"}, "681": {"seminar_date": "Tue, Oct 13, 2020", "seminar_time": "15:00", "timezone": "Europe/Paris", "posted": "yes", "seminar_link": "http://bit.ly/38pRy4f", "password": "", "video_on_demand": "http://www.ern-rnd.eu/education-training/past-webinars/", "speaker_title": "", "seminar_speaker": "Juan Dario Ortigoza-Escobar", "speaker_affil": "Sant Joan de D\u00e9u Hospital, Barcelona, Spain", "speaker_twitter": "@SJDbarcelona_es @ERN_RND", "speaker_website": "www.ern-rnd.eu/education-training/webinars/", "topic_tags": "neurology, paediatric", "seminar_title": "Diagnostic algorithm for childhood onset chorea", "seminar_abstract": "", "hosted_by": "ERN-RND", "domain": ["Neuroscience"], "calendar_event_hash": "f1d7089a34e95335cb7f3fbb8620cdb4877218f87ddc1367f23cf485fc6a4857", "seminar_id": 681, "time_of_addition": "Thu, Sep 17, 2020 14:10"}, "682": {"seminar_date": "Tue, Oct 20, 2020", "seminar_time": "15:00", "timezone": "Europe/Paris", "posted": "yes", "seminar_link": "https://bit.ly/3c7yVpb", "password": "", "video_on_demand": "http://www.ern-rnd.eu/education-training/past-webinars/", "speaker_title": "", "seminar_speaker": "Bernhard Landwehrmeyer", "speaker_affil": "University Ulm, Germany", "speaker_twitter": "@ERN_RND", "speaker_website": "www.ern-rnd.eu/education-training/webinars/", "topic_tags": "rare neurological disorders, neurology", "seminar_title": "Clinical practice recommendations for physical therapy for Huntington\u2019s disease", "seminar_abstract": "", "hosted_by": "ERN-RND", "domain": ["Neuroscience"], "calendar_event_hash": "61ff3e9885110b5ed650a175f370ee8753937f03e21b9fa51912ffe3bc7d10ee", "seminar_id": 682, "time_of_addition": "Thu, Sep 17, 2020 14:10"}, "683": {"seminar_date": "Tue, Nov 3, 2020", "seminar_time": "15:00", "timezone": "Europe/Paris", "posted": "yes", "seminar_link": "https://bit.ly/3c6bqNk", "password": "", "video_on_demand": "http://www.ern-rnd.eu/education-training/past-webinars/", "speaker_title": "", "seminar_speaker": "Bart van de Warrenburg", "speaker_affil": "Radboud University Medical Centre, Nijmegen, Netherlands", "speaker_twitter": "@radboudumc @ERN_RND", "speaker_website": "www.ern-rnd.eu/education-training/webinars/", "topic_tags": "rare neurological disorders, neurology, ataxia", "seminar_title": "Non-invasive stimulation for ataxias", "seminar_abstract": "", "hosted_by": "ERN-RND", "domain": ["Neuroscience"], "calendar_event_hash": "c51250b7e6f3c5c653df7e21af5c4a24f70d49a40c614a63db23c0b52c9d6c2b", "seminar_id": 683, "time_of_addition": "Thu, Sep 17, 2020 14:30"}, "684": {"seminar_date": "Tue, Nov 10, 2020", "seminar_time": "15:00", "timezone": "Europe/Paris", "posted": "yes", "seminar_link": "https://bit.ly/32DSC4X", "password": "", "video_on_demand": "http://www.ern-rnd.eu/education-training/past-webinars/", "speaker_title": "", "seminar_speaker": "Ludger Sch\u00f6ls", "speaker_affil": "University of T\u00fcbingen, Germany", "speaker_twitter": "@uktuebingen @ERN_RND", "speaker_website": "www.ern-rnd.eu/education-training/webinars/", "topic_tags": "rare neurological disorders, neurology, ataxia", "seminar_title": "Rehabilitation in ataxia: current evidence and practice", "seminar_abstract": "", "hosted_by": "ERN-RND", "domain": ["Neuroscience"], "calendar_event_hash": "fdc175899136cc850470b28151a37563bc9a1a84bb1ff396b77463ebdaeee9c1", "seminar_id": 684, "time_of_addition": "Thu, Sep 17, 2020 14:35"}, "685": {"seminar_date": "Tue, Nov 24, 2020", "seminar_time": "15:00", "timezone": "Europe/Paris", "posted": "yes", "seminar_link": "https://bit.ly/32EXBSR", "password": "", "video_on_demand": "http://www.ern-rnd.eu/education-training/past-webinars/", "speaker_title": "", "seminar_speaker": "Gessica Vasco & Susanna Summa", "speaker_affil": "Ospedale Pediatrico Bambino Ges\u00f9, Rome, Italy", "speaker_twitter": "@bambinogesu @ERN_RND", "speaker_website": "www.ern-rnd.eu/education-training/webinars/", "topic_tags": "rare neurological disorders, neurology", "seminar_title": "Development of Sara-home: a novel assessment tool for patients with ataxia", "seminar_abstract": "", "hosted_by": "ERN-RND", "domain": ["Neuroscience"], "calendar_event_hash": "78b99e57ec676010e6859165008d36e4846f34d3f28a39473ad01b5f7ac180f0", "seminar_id": 685, "time_of_addition": "Thu, Sep 17, 2020 14:35"}, "686": {"seminar_date": "Tue, Dec 1, 2020", "seminar_time": "15:00", "timezone": "Europe/Paris", "posted": "yes", "seminar_link": "https://bit.ly/3c9QapP", "password": "", "video_on_demand": "http://www.ern-rnd.eu/education-training/past-webinars/", "speaker_title": "", "seminar_speaker": "Christos Ganos", "speaker_affil": "Charit\u00e9, University Medicine, Berlin, Germany", "speaker_twitter": "@ChristosGanos", "speaker_website": "www.ern-rnd.eu/education-training/webinars/", "topic_tags": "movement disorders", "seminar_title": "Functional movement disorders: a diagnostic guide", "seminar_abstract": "", "hosted_by": "ERN-RND", "domain": ["Neuroscience"], "calendar_event_hash": "3a790198de26ed22d49c273af5e43a7787b3eda159f3ab181fbfdab4b5de5c21", "seminar_id": 686, "time_of_addition": "Thu, Sep 17, 2020 14:45"}, "657": {"seminar_date": "Thu, Aug 20, 2020", "seminar_time": "10:00", "timezone": "America/Los_Angeles", "posted": "yes", "seminar_link": "https://us02web.zoom.us/meeting/register/tZclcuCprT4qH9O-DZ3EB8Rab7h1PvHZhZLY", "password": "", "video_on_demand": "", "speaker_title": "", "seminar_speaker": "Elise Brimble MSC, MS, CGC", "speaker_affil": "Citizen", "speaker_twitter": "", "speaker_website": "https://syngapresearchfund.org/webinars", "topic_tags": "disease, epilepsy neuroscience, genetics, neurodevelopmental disorders", "seminar_title": "Leveraging technology to improve access to rare disease research", "seminar_abstract": "", "hosted_by": "SYNGAP1 by SRF", "domain": ["Neuroscience"], "calendar_event_hash": "3eca1e5e14d006b380ca44e97023dda7209048c109ee9fda184ec8bace02ebad", "seminar_id": 657, "time_of_addition": "Tue, Sep 15, 2020 13:30"}, "658": {"seminar_date": "Thu, Sep 17, 2020", "seminar_time": "9:00", "timezone": "America/Los_Angeles", "posted": "yes", "seminar_link": "https://us02web.zoom.us/meeting/register/tZEkfuuvpjIvGd3hEGLMBOzHcN7MjA_cphYV", "password": "", "video_on_demand": "", "speaker_title": "", "seminar_speaker": "Dr. Richard Huganir", "speaker_affil": "Johns Hopkins University", "speaker_twitter": "", "speaker_website": "https://syngapresearchfund.org/webinars", "topic_tags": "disease, epilepsy neuroscience, genetics, neurodevelopmental disorders, behaviour, SYNGAP", "seminar_title": "Rescue of SynGAP expression in SYNGAP1 Syndrome: Antisense Oligonucleotides (ASOs), small molecules, & viral genetic rescue", "seminar_abstract": "", "hosted_by": "SYNGAP1 by SRF", "domain": ["Neuroscience"], "calendar_event_hash": "d596917ee871a9a7286133d3be079e58116ed062b35223ae40b52ad95868013e", "seminar_id": 658, "time_of_addition": "Tue, Sep 15, 2020 13:30"}, "753": {"seminar_date": "Thu, Oct 1, 2020", "seminar_time": "8:00", "timezone": "America/Los_Angeles", "posted": "yes", "seminar_link": "https://us02web.zoom.us/webinar/register/WN_t4Hd4M0BRXuzkdCPU0dlWg", "password": "", "video_on_demand": "", "speaker_title": "", "seminar_speaker": "Dr. James Clement", "speaker_affil": "Neuroscience Unit, Jawaharlal Nehru Centre for Advanced Scientific Research", "speaker_twitter": "", "speaker_website": "https://syngapresearchfund.org/webinars", "topic_tags": "disease, epilepsy neuroscience, genetics, neurodevelopmental disorders, behaviour, SYNGAP", "seminar_title": "Towards therapeutics for Autism Spectrum Disorder using Syngap1 heterozygous mouse model", "seminar_abstract": "", "hosted_by": "SYNGAP1 by SRF", "domain": ["Neuroscience"], "calendar_event_hash": "a22b2be6d5bed702e2022926bd39044032fd30272b7bf8c3c28148b4dc948fdf", "seminar_id": 753, "time_of_addition": "Fri, Sep 25, 2020 00:30"}, "754": {"seminar_date": "Thu, Oct 15, 2020", "seminar_time": "10:00", "timezone": "America/Los_Angeles", "posted": "yes", "seminar_link": "https://us02web.zoom.us/meeting/register/tZIsf--prDwqGNVVB-KmjVm6I0nkr85Cjw2v", "password": "", "video_on_demand": "", "speaker_title": "", "seminar_speaker": "Dr. Heather C. Mefford", "speaker_affil": "University of Washington in the Division of Genetic Medicine", "speaker_twitter": "", "speaker_website": "https://syngapresearchfund.org/webinars", "topic_tags": "disease, epilepsy neuroscience, genetics, neurodevelopmental disorders, behaviour, SYNGAP", "seminar_title": "SYNGAP1: The road from gene discovery to targeted therapy", "seminar_abstract": "", "hosted_by": "SYNGAP1 by SRF", "domain": ["Neuroscience"], "calendar_event_hash": "92c999af03b44fff6a910d1602748c68b6f8253a4e67731a216fc0655b537e53", "seminar_id": 754, "time_of_addition": "Fri, Sep 25, 2020 00:35"}, "805": {"seminar_date": "Mon, June 22, 2020", "seminar_time": "11:00", "timezone": "America/New_York", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/brainbodyinteractions", "password": "", "video_on_demand": "https://www.crowdcast.io/e/brainbodyinteractions", "speaker_title": "Prof", "seminar_speaker": "Stephen Liberles", "speaker_affil": "Harvard Medical School, Boston, MA, USA", "speaker_twitter": "", "speaker_website": "https://liberles.hms.harvard.edu/", "topic_tags": "vagus, breathing, mouse", "seminar_title": "Vagal sensory neurons that guard the airways", "seminar_abstract": "The vagus nerve contains a diversity of sensory neurons that detect peripheral stimuli such as blood pressure changes at the aortic arch, lung expansion during breathing, meal-induced stomach distension, and chemotherapeutics that induce nausea. Underlying vagal sensory mechanisms are largely unresolved at a molecular level, presenting tremendously important problems in sensory biology. We charted vagal sensory neurons by single cell RNA sequencing, identifying novel cell surface receptors and classifying a staggering diversity of sensory neuron types. We then generated a collection of ires-Cre knock-in mice to target each neuron type, and adapted genetic tools for Cre-based anatomical mapping, in vivo imaging, targeted ablation, and optogenetic control of vagal neuron activity. We found different sensory neuron types that innervate the lung and exert powerful effects on breathing, others that monitor and control the digestive system, and yet others that innervate that innervate the larynx and protect the airways. Together with Ardem Patapoutian, we also identified a critical role for Piezo mechanoreceptors in the sensation of airway stretch, which underlies a classical respiratory reflex termed the Hering-Breuer inspiratory reflex, as well as in the neuronal sensation of blood pressure and the baroreceptor reflex.", "hosted_by": "Brain-Body Interactions", "domain": ["Neuroscience"], "calendar_event_hash": "9948da0c48829faff1c79ca71afe4e333e50830323781178f72b3b2eaa41eb39", "seminar_id": 805, "time_of_addition": "Mon, Sep 28, 2020 11:06"}, "806": {"seminar_date": "Mon, Jun 29, 2020", "seminar_time": "11:00", "timezone": "America/New_York", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/BrainBody-Schwartz", "password": "", "video_on_demand": "https://youtu.be/CPwHxLF4EI8", "speaker_title": "Prof.", "seminar_speaker": "Michal Schwartz", "speaker_affil": "Weizmann Institute of Science", "speaker_twitter": "", "speaker_website": "https://www.weizmann.ac.il/neurobiology/labs/schwartz/home", "topic_tags": "neuroimmunology, immune, neurodegeneration", "seminar_title": "Novel immunotherapy to treat Alzheimer\u2019s disease and Dementia: from curiosity-driven research to prospect of therapy", "seminar_abstract": "", "hosted_by": "Brain-Body Interactions", "domain": ["Neuroscience"], "calendar_event_hash": "c3b626176ffe32756bdec7ee904eac6719034dcdeb8c071790eab2420f76a298", "seminar_id": 806, "time_of_addition": "Mon, Sep 28, 2020 11:06"}, "807": {"seminar_date": "Mon, Jul 20, 2020", "seminar_time": "16:00", "timezone": "Europe/Lisbon", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/brainbody-dus", "password": "", "video_on_demand": "", "speaker_title": "Prof.", "seminar_speaker": "Monica Dus", "speaker_affil": "University of Michigan", "speaker_twitter": "@Hardkandy000", "speaker_website": "https://sites.lsa.umich.edu/dus-lab/", "topic_tags": "metabolism, taste, hunger, drosophila, epigenetics", "seminar_title": "Epigenetic Reprogramming of Taste by Diet", "seminar_abstract": "Diets rich in sugar, salt, and fat alter taste perception and food intake, leading to obesity and metabolic disorders, but the molecular mechanisms through which this occurs are unknown. Here we show that in response to a high sugar diet, the epigenetic regulator Polycomb Repressive Complex 2.1 (PRC2.1) persistently reprograms the sensory neurons of D. melanogaster flies to reduce sweet sensation and promote obesity. In animals fed high sugar, the binding of PRC2.1 to the chromatin of the sweet gustatory neurons is redistributed to repress a developmental transcriptional network that modulates the responsiveness of these cells to sweet stimuli, reducing sweet sensation. Importantly, half of these transcriptional changes persist despite returning the animals to a control diet, causing a permanent decrease in sweet taste. Our results uncover a new epigenetic mechanism that, in response to the dietary environment, regulates neural plasticity and feeding behavior to promote obesity.", "hosted_by": "Brain-Body Interactions", "domain": ["Neuroscience"], "calendar_event_hash": "f49d0cb0fd15d19e42850310fe0bac88c4a7d0e3d7d7f19999c564cec4af6ffb", "seminar_id": 807, "time_of_addition": "Mon, Sep 28, 2020 11:06"}, "415": {"seminar_date": "Mon, Sep 7, 2020", "seminar_time": "10:00", "timezone": "Europe/Lisbon", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/brainbody-simpson", "password": "", "video_on_demand": "https://www.youtube.com/watch?v=FRJdkgb91lQ", "speaker_title": "Prof.", "seminar_speaker": "Stephen J. Simpson", "speaker_affil": "University of Sydney", "speaker_twitter": "@eatlikeanimals", "speaker_website": "https://www.sydney.edu.au/science/about/our-people/academic-staff/stephen-simpson.html", "topic_tags": "animal lifetraits", "seminar_title": "Towards resolving the Protein Paradox in longevity and late-life health", "seminar_abstract": "Reducing protein intake (and that of key amino acids) extends lifespan, especially during mid-life and early late-life. Yet, due to a powerful protein appetite, reducing protein in the diet leads to increased food intake, promoting obesity \u2013 which shortens lifespan. That is the protein paradox. In the talk I will bring together pieces of the jigsaw, including: specific nutrient appetites, protein leverage, macronutrient interactions on appetite and ageing, the role of branched-chain amino acids and FGF-21, and then I will conclude by showing how these pieces fit together and play out in the modern industrialised food environment to result in the global pandemic of obesity and metabolic disease.", "hosted_by": "Brain-Body Interactions", "domain": ["Neuroscience"], "calendar_event_hash": "d2d24f304b26eecd29bc5eb3ba6393da403a72225184af1ca4db13c7df4c3069", "seminar_id": 415, "time_of_addition": "Tue, Aug 04, 2020 00:05"}, "460": {"seminar_date": "Mon, Sep 14, 2020", "seminar_time": "16:00", "timezone": "Europe/Lisbon", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/brainbody-miguel-aliaga", "password": "", "video_on_demand": "", "speaker_title": "Prof.", "seminar_speaker": "Irene Miguel-Aliaga", "speaker_affil": "Imperial College London", "speaker_twitter": "@FlyGutLab", "speaker_website": "http://www.miguelaliagalab.com/", "topic_tags": "", "seminar_title": "Sex, guts and babies: the plasticity of the adult intestine and its neurons", "seminar_abstract": "Internal organs constantly exchange signals, and can respond with striking anatomical and functional transformations, even in fully developed organisms. We are exploring the mechanisms that drive and sustain such plasticity using the intestine and its neurons as experimental systems. I will present some of our recent work, which has characterised the enteric nervous system of Drosophila, and has explored its physiological plasticity as well as that of the intestine itself. This work has uncovered unexpected sexual dimorphisms, intestinal contributions to reproductive success and metabolic crosstalk between the gut and the brain. Interestingly, this crosstalk appears to be spatially constrained by the three dimensional arrangement of viscera, revealing a previously unrecognised layer of inter-organ signalling regulation. I may also describe our attempts to explore how broadly applicable our findings may be using mammalian systems.", "hosted_by": "Brain-Body Interactions", "domain": ["Neuroscience"], "calendar_event_hash": "df15d865ae34884a5b543180e193b2e41d641db1437cf5a4a2eb737f7834b94c", "seminar_id": 460, "time_of_addition": "Wed, Aug 12, 2020 13:25"}, "655": {"seminar_date": "Mon, Sep 21, 2020", "seminar_time": "16:00", "timezone": "Europe/Lisbon", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/brainbody-chiu", "password": "", "video_on_demand": "https://www.youtube.com/watch?v=nRbVqG3mvrk&t=863s", "speaker_title": "Prof.", "seminar_speaker": "Isaac Chiu", "speaker_affil": "Harvard Medical School, Boston, MA, USA", "speaker_twitter": "@isaacmchiu", "speaker_website": "https://chiulab.med.harvard.edu/", "topic_tags": "neuroimmune, pain, host defense", "seminar_title": "Neuro-immune interactions in pain and host defense", "seminar_abstract": "The Chiu laboratory focuses on neuro-immune interactions in pain, itch, and tissue inflammation. Dr. Chiu\u2019s research has uncovered molecular interactions between the nervous system, the immune system and microbes that modulates host defense. He has found that sensory neurons can directly detect bacterial pathogens and their toxins to produce pain. Neurons in turn release neuropeptides that modulate immune cells in host defense. These interactions occur at major tissue barriers in the body including the gut, skin and lungs. In this talk, he will discuss these major neuro-immune interactions and how understanding them could lead to novel approaches to treat pain or inflammation.", "hosted_by": "Brain-Body Interactions", "domain": ["Neuroscience"], "calendar_event_hash": "cbf9662a28eb26615049537fe22f1fcd8dac439fa3c8a0b6c8091e2c9f086ee4", "seminar_id": 655, "time_of_addition": "Mon, Sep 14, 2020 10:35"}, "416": {"seminar_date": "Mon, Sep 28, 2020", "seminar_time": "16:00", "timezone": "Europe/Lisbon", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/brainbody-schirmeier", "password": "", "video_on_demand": "https://www.youtube.com/watch?v=ypZZgl-vSps", "speaker_title": "Dr.", "seminar_speaker": "Stephanie Schirmeier", "speaker_affil": "University of Munster", "speaker_twitter": "", "speaker_website": "http://schirmeier.uni-muenster.de/", "topic_tags": "metabolism, neuron-glia communication", "seminar_title": "Glia neuron metabolic interactions in Drosophila", "seminar_abstract": "To function properly, the nervous system consumes vast amounts of energy, which is mostly provided by carbohydrate metabolism. Neurons are very sensitive to changes in the extracellular fluid surrounding them, which necessitated shielding of the nervous system from fluctuating solute concentrations in circulation. This is achieved by the blood-brain barrier (BBB) that prevents paracellular diffusion of solutes into the nervous system. This in turn also means that all nutrients that are needed e.g. for sufficient energy supply need to be transported over the BBB. We use Drosophila as a model system to better understand the metabolic homeostasis in the central nervous system.\nGlial cells play essential roles in both nutrient uptake and neural energy metabolism. Carbohydrate transport over the glial BBB is well-regulated and can be adapted to changes in carbohydrate availability. Furthermore, Drosophila glial cell are highly glycolytic cells that support the rather oxidative metabolism of neurons. Upon perturbations of carbohydrate metabolism, the glial cells prove to be metabolically very flexible and able to adapt to changing circumstances. I will summarize what we know about carbohydrate transport at the Drosophila BBB and about the metabolic coupling between neurons and glial cells. Our data shows that many basic features of neural metabolism are well conserved between the fly and mammals.", "hosted_by": "Brain-Body Interactions", "domain": ["Neuroscience"], "calendar_event_hash": "233340832038c4ab3d3398436789f21787677ab87095b694b0c0fd482524767b", "seminar_id": 416, "time_of_addition": "Tue, Aug 04, 2020 00:05"}, "752": {"seminar_date": "Mon, Oct 5, 2020", "seminar_time": "16:00", "timezone": "Europe/Lisbon", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/brainbody-kipnis", "password": "", "video_on_demand": "", "speaker_title": "Prof.", "seminar_speaker": "Jonathan Kipnis", "speaker_affil": "Washington University in St Louis, Missouri", "speaker_twitter": "@kipnislab", "speaker_website": "https://kipnislab.wustl.edu/", "topic_tags": "neuroimmunology", "seminar_title": "Meningeal lymphatics and peripheral immunity in brain function and dysfunction", "seminar_abstract": "Immune cells and their derived molecules have major impact on brain function. Mice deficient in adaptive immunity have impaired cognitive and social function compared to that of wild-type mice. Importantly, replenishment of the T cell compartment in immune deficient mice restored proper brain function. Despite the robust influence on brain function, T cells are not found within the brain parenchyma, a fact that only adds more mystery into these enigmatic interactions between T cells and the brain. Our results suggest that meningeal space, surrounding the brain, is the site where CNS-associated immune activity takes place. We have recently discovered a presence of meningeal lymphatic vessels that drain CNS molecules and immune cells to the deep cervical lymph nodes. This communication between the CNS and the peripheral immunity is playing a key role in neurophysiology and in several CNS disorders. Interestingly, meningeal lymphatics are impaired in aging and their dysfunction may be related to age-related cognitive decline as well as to Alzheimer\u2019s pathology. In addition to providing new insights into age-related disorders, meningeal lymphatics may also serve as a novel therapeutic target for these diseases and are worth of in-depth mechanistic exploration.", "hosted_by": "Brain-Body Interactions", "domain": ["Neuroscience"], "calendar_event_hash": "c3cb6656b4521e4eb880bf8fa7dc2903a33ae1d0e9fd4765aeec33a67d565703", "seminar_id": 752, "time_of_addition": "Thu, Sep 24, 2020 19:45"}, "1159": {"seminar_date": "Mon, Oct 12, 2020", "seminar_time": "16:00", "timezone": "Europe/Lisbon", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/brainbody-dickerson", "password": "", "video_on_demand": "", "speaker_title": "Dr.", "seminar_speaker": "Brad Dickerson", "speaker_affil": "University of North Carolina", "speaker_twitter": "@yelzebub", "speaker_website": "http://dickerson.bio.unc.edu/", "topic_tags": "locomotion, flight, mechanosensation, halteres, muscles, drosophila", "seminar_title": "An evolutionarily conserved hindwing circuit mediates Drosophila flight control", "seminar_abstract": "My research at the interface of neurobiology, biomechanics, and behavior seeks to understand how the timing precision of sensory input structures locomotor output. My lab studies the flight behavior of the fruit fly, Drosophila melanogaster, combining powerful genetic tools available for labeling and manipulating neural circuits with cutting-edge imaging in awake, behaving animals. This work has the potential to fundamentally reshape understanding of the evolution of insect flight, as well as highlight the tremendous importance of timing in the context of locomotion. Timing is crucial to the nervous system. The ability to rapidly detect and process subtle disturbances in the environment determines whether an animal can attain its next meal or successfully navigate complex, unpredictable terrain. While previous work on various animals has made tremendous strides uncovering the specialized neural circuits used to resolve timing differences with sub-microsecond resolution, it has focused on the detection of timing differences in sensory systems. Understanding of how the timing of motor output is structured by precise sensory input remains poor. My research focuses on an organ unique to fruit flies, called the haltere, that serves as a bridge for detecting and acting on subtle timing differences, helping flies execute rapid maneuvers. Understanding how this relatively simple insect canperform such impressive aerial feats demands an integrative approach that combines physics, muscle mechanics, neuroscience, and behavior. This unique, powerful approach will reveal the general principles that govern sensorimotor processing.", "hosted_by": "Brain-Body Interactions", "domain": ["Neuroscience"], "calendar_event_hash": "ce030c47ef51d6184fda81b6486129440ca3f4e6cd894d84c6d90f631f69314b", "seminar_id": 1159, "time_of_addition": "Tue, Oct 06, 2020 10:10"}, "453": {"seminar_date": "Thu, Aug 27, 2020", "seminar_time": "16:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://www.ucl.ac.uk/biosciences/ucl-iha-virtual-symposium-neurodegeneration-flies", "password": "", "video_on_demand": "", "speaker_title": "", "seminar_speaker": "Hugo Bellen", "speaker_affil": "Baylor College of Medicine", "speaker_twitter": "", "speaker_website": "http://flypush.imgen.bcm.tmc.edu/lab/index.html", "topic_tags": "drosophila, neurodegeneration, Alzheimer's, Parkinson's, genetics", "seminar_title": "The study of rare neurological diseases drives discoveries for common diseases", "seminar_abstract": "", "hosted_by": "Neurodegeneration in Flies", "domain": ["Neuroscience"], "calendar_event_hash": "7f766408389a8acc50fccff0c7004bb5af62457624af59b6441e16bef03e98bc", "seminar_id": 453, "time_of_addition": "Wed, Aug 12, 2020 10:55"}, "454": {"seminar_date": "Thu, Sep 10, 2020", "seminar_time": "16:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://www.ucl.ac.uk/biosciences/ucl-iha-virtual-symposium-neurodegeneration-flies", "password": "", "video_on_demand": "", "speaker_title": "", "seminar_speaker": "Sean Sweeney", "speaker_affil": "University of York", "speaker_twitter": "", "speaker_website": "https://www.york.ac.uk/biology/research/developmental-biology/sean-t-sweeney/", "topic_tags": "drosophila, neurodegeneration, Alzheimer's, Parkinson's, genetics", "seminar_title": "Identifying pathological events and therapeutics in FTD-ALS using Drosophila", "seminar_abstract": "", "hosted_by": "Neurodegeneration in Flies", "domain": ["Neuroscience"], "calendar_event_hash": "e12da576d2f40050993bc9be87109138572462d2c2cf180fd24f62048c74ef42", "seminar_id": 454, "time_of_addition": "Wed, Aug 12, 2020 10:55"}, "455": {"seminar_date": "Thu, Sep 24, 2020", "seminar_time": "16:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://www.ucl.ac.uk/biosciences/ucl-iha-virtual-symposium-neurodegeneration-flies", "password": "", "video_on_demand": "", "speaker_title": "", "seminar_speaker": "Pedro Fernandez-Funez", "speaker_affil": "University of Minnesota", "speaker_twitter": "", "speaker_website": "https://med.umn.edu/bio/biomedsci/pedro-fernandez-funez", "topic_tags": "drosophila, neurodegeneration, Alzheimer's, Parkinson's, genetics", "seminar_title": "Unraveling the intrinsic and extrinsic mechanisms underlying the toxicity of the prion protein", "seminar_abstract": "", "hosted_by": "Neurodegeneration in Flies", "domain": ["Neuroscience"], "calendar_event_hash": "ebaa38430650d8b98b92aa8c19c351a0dbcaf958a7a2fb0f52ffe9a1e717dc6b", "seminar_id": 455, "time_of_addition": "Wed, Aug 12, 2020 10:55"}, "456": {"seminar_date": "Thu, Oct 8, 2020", "seminar_time": "16:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://www.ucl.ac.uk/biosciences/ucl-iha-virtual-symposium-neurodegeneration-flies", "password": "", "video_on_demand": "", "speaker_title": "", "seminar_speaker": "Patrik Verstreken", "speaker_affil": "VIB-KU Leuven", "speaker_twitter": "", "speaker_website": "https://vib.be/labs/patrik-verstreken-lab", "topic_tags": "drosophila, neurodegeneration, Alzheimer's, Parkinson's, genetics", "seminar_title": "The cellular phase of Parkinson's disease", "seminar_abstract": "", "hosted_by": "Neurodegeneration in Flies", "domain": ["Neuroscience"], "calendar_event_hash": "b99aa0a3c6ef0f6dbea4bfce0ea61a937d0a2e58dca94336fd4c9e78bed4c598", "seminar_id": 456, "time_of_addition": "Wed, Aug 12, 2020 10:55"}, "457": {"seminar_date": "Thu, Oct 22, 2020", "seminar_time": "16:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://www.ucl.ac.uk/biosciences/ucl-iha-virtual-symposium-neurodegeneration-flies", "password": "", "video_on_demand": "", "speaker_title": "", "seminar_speaker": "Amritpal Mudher", "speaker_affil": "University of Southampton", "speaker_twitter": "", "speaker_website": "https://www.southampton.ac.uk/biosci/about/staff/amrit.page", "topic_tags": "drosophila, neurodegeneration, Alzheimer's, Parkinson's, genetics", "seminar_title": "Tau tangles in Drosophila models of tauopathy - fact or fiction?", "seminar_abstract": "", "hosted_by": "Neurodegeneration in Flies", "domain": ["Neuroscience"], "calendar_event_hash": "339f71df9a4f8d6390bafd1fdfee3aa66dce8ec7ff62c8ec989f998ea078b088", "seminar_id": 457, "time_of_addition": "Wed, Aug 12, 2020 10:55"}, "458": {"seminar_date": "Thu, Nov 5, 2020", "seminar_time": "16:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://www.ucl.ac.uk/biosciences/ucl-iha-virtual-symposium-neurodegeneration-flies", "password": "", "video_on_demand": "", "speaker_title": "", "seminar_speaker": "Joshua Shulman", "speaker_affil": "Baylor College of Medicine", "speaker_twitter": "", "speaker_website": "https://shulman-lab.org/team/shulman.shtml", "topic_tags": "drosophila, neurodegeneration, Alzheimer's, Parkinson's, genetics", "seminar_title": "", "seminar_abstract": "", "hosted_by": "Neurodegeneration in Flies", "domain": ["Neuroscience"], "calendar_event_hash": "a565c29c635a133586da7e4a53e4123fe9d13dc5e7e597e5360548a43437232d", "seminar_id": 458, "time_of_addition": "Wed, Aug 12, 2020 10:55"}, "459": {"seminar_date": "Thu, Nov 19, 2020", "seminar_time": "16:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://www.ucl.ac.uk/biosciences/ucl-iha-virtual-symposium-neurodegeneration-flies", "password": "", "video_on_demand": "", "speaker_title": "", "seminar_speaker": "Mel Feany", "speaker_affil": "Harvard Medical School", "speaker_twitter": "", "speaker_website": "http://feany-lab.bwh.harvard.edu/", "topic_tags": "drosophila, neurodegeneration, Alzheimer's, Parkinson's, genetics", "seminar_title": "", "seminar_abstract": "", "hosted_by": "Neurodegeneration in Flies", "domain": ["Neuroscience"], "calendar_event_hash": "830a8c00f928f06117984fb30d9b98c913aa28d2df7f3a0044717c5d0ab81b38", "seminar_id": 459, "time_of_addition": "Wed, Aug 12, 2020 10:55"}, "739": {"seminar_date": "Thu, Dec 3, 2020", "seminar_time": "16:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://www.ucl.ac.uk/biosciences/ucl-iha-virtual-symposium-neurodegeneration-flies", "password": "", "video_on_demand": "", "speaker_title": "", "seminar_speaker": "Alex Whitworth", "speaker_affil": "University of Cambridge", "speaker_twitter": "", "speaker_website": "http://www.mrc-mbu.cam.ac.uk/people/alex-whitworth", "topic_tags": "drosophila, neurodegeneration, Alzheimer's, Parkinson's, genetics", "seminar_title": "", "seminar_abstract": "", "hosted_by": "Neurodegeneration in Flies", "domain": ["Neuroscience"], "calendar_event_hash": "2d97bed9b1a566a1db88e60e49db032fb8b5b621bd316650c971b2debf81051e", "seminar_id": 739, "time_of_addition": "Tue, Sep 22, 2020 12:40"}, "670": {"seminar_date": "Tue, Sep 15, 2020", "seminar_time": "16:00", "timezone": "Canada/Eastern", "posted": "yes", "seminar_link": "https://www.mcgill.ca/neuro/channels/event/killam-seminar-series-mechanisms-perceptual-learning-324309", "password": "", "video_on_demand": "https://vimeo.com/event/266553", "speaker_title": "Dr.", "seminar_speaker": "Takeo Watanabe", "speaker_affil": "", "speaker_twitter": "", "speaker_website": "", "topic_tags": "perceptual learning", "seminar_title": "Mechanisms of Perceptual Learning", "seminar_abstract": "Perceptual learning (PL) is defined as long-term performance improvement on a perceptual task as a result of perceptual experience (Sasaki, Nanez& Watanabe, 2011, Nat Rev Neurosci, 2011). We first found that PL occurs for task-irrelevant and subthreshold features and that pairing task-irrelevant features with rewards is the key to form task-irrelevant PL (TIPL) (Watanabe, Nanez & Sasaki, Nature, 2001; Watanabe et al, 2002, Nature Neuroscience; Seitz & Watanabe, Nature, 2003; Seitz, Kim & Watanabe, 2009, Neuron; Shibata et al, 2011, Science). These results suggest that PL occurs as a result of interactions between reinforcement and bottom-up stimulus signals (Seitz & Watanabe, 2005, TICS). On the other hand, fMRI study results indicate that lateral prefrontal cortex fails to detect and thus to suppress subthreshold task-irrelevant signals. This leads to the paradoxical effect that a signal that is below, but close to, one\u2019s discrimination threshold ends up being stronger than suprathreshold signals (Tsushima, Sasaki & Watanabe, 2006, Science). We confirmed this mechanism with the following results: Task-irrelevant learning occurs only when a presented feature is under and close to the threshold with younger individuals (Tsushima et al, 2009, Current Biol), whereas with older individuals who tend to have less inhibitory control task-irrelevant learning occurs with a feature whose signal is much greater than the threshold (Chang et al, 2014, Current Biol). From all of these results, we conclude that attention and reward play important but different roles in PL. I will further discuss different stages and phases in mechanisms of PL (Seitz et al, 2005, PNAS; Yotsumoto, Watanabe & Sasaki, Neuron, 2008; Yotsumoto et al, Curr Biol, 2009; Watanabe & Sasaki, 2015, Ann Rev Psychol; Shibata et al, 2017, Nat Neurosci; Tamaki et al, 2020, Nat Neurosci).", "hosted_by": "McGill Killam Neuro", "domain": ["Neuroscience"], "calendar_event_hash": "b0ebcdd03fb4f9d14331971804ed8aaaf7639d5a4c03d176ed6e8b705bfa95e6", "seminar_id": 670, "time_of_addition": "Tue, Sep 15, 2020 18:05"}, "720": {"seminar_date": "Tue, Sep 29, 2020", "seminar_time": "16:00", "timezone": "Canada/Eastern", "posted": "yes", "seminar_link": "https://www.mcgill.ca/neuro/channels/event/killam-seminar-series-dopamine-synapse-and-learning-324619", "password": "", "video_on_demand": "https://vimeo.com/event/266553", "speaker_title": "Dr.", "seminar_speaker": "David Sulzer", "speaker_affil": "", "speaker_twitter": "", "speaker_website": "", "topic_tags": "striatum, dopamine, avoidance learning", "seminar_title": "The Dopamine Synapse and Learning", "seminar_abstract": "The actions of dopamine within the striatum are central to the selection of cortical and perhaps thalamic inputs that mediate learning throughout life, including during operant conditioning, reward and avoidance learning and the establishment of motor patterns. Dysfunction of these synaptic circuits during maturation or aging underlies many neurological, psychiatric and neurodevelopment disorders. We will discuss the biological sequences by which these synapses are altered as an animal interacts with the environment.", "hosted_by": "McGill Killam Neuro", "domain": ["Neuroscience"], "calendar_event_hash": "2340ae388f677e8430cc1b2e384384ad3da82026573d373be50a8ca4113bfe13", "seminar_id": 720, "time_of_addition": "Mon, Sep 21, 2020 17:30"}, "946": {"seminar_date": "Tue, Oct 6, 2020", "seminar_time": "16:00", "timezone": "Canada/Eastern", "posted": "yes", "seminar_link": "https://www.mcgill.ca/neuro/channels/event/killam-seminar-series-hippobellum-lincs-324981", "password": "", "video_on_demand": "https://vimeo.com/event/266553", "speaker_title": "Dr.", "seminar_speaker": "Esther Krook-Magnuson", "speaker_affil": "University of Minnesota", "speaker_twitter": "", "speaker_website": "", "topic_tags": "hippocampus, cerebellum, spatial navigation, interneurons", "seminar_title": "To & From: Hippobellum & LINCs", "seminar_abstract": "The hippocampus is a well-studied structure, important for spatial navigation, learning, and memory. The hippocampus, however, still contains secrets and does not work in a vacuum. LINCs are a novel form of long-range inhibitory neuron in the hippocampus, which may be important for coordinating activity between the hippocampus and downstream structures. The cerebellum, while classically viewed as a motor structure, is being increasingly recognized for its impact on cognitive domains. Recent work has demonstrated that the cerebellum can influence the hippocampus, including place cells.", "hosted_by": "McGill Killam Neuro", "domain": ["Neuroscience"], "calendar_event_hash": "4ca30283e783cf1d27310f101ffae3869f6a56afd54ce1b28cbd0bbedff666de", "seminar_id": 946, "time_of_addition": "Wed, Sep 30, 2020 15:55"}, "1157": {"seminar_date": "Tue, Oct 20, 2020", "seminar_time": "16:00", "timezone": "Canada/Eastern", "posted": "yes", "seminar_link": "https://www.mcgill.ca/neuro/channels/event/killam-seminar-series-programmed-axon-death-and-its-roles-human-disease-325159", "password": "", "video_on_demand": "https://vimeo.com/event/266553", "speaker_title": "Dr.", "seminar_speaker": "Michael Coleman", "speaker_affil": "University of Cambridge", "speaker_twitter": "", "speaker_website": "", "topic_tags": "", "seminar_title": "Programmed Axon Death and its Roles in Human Disease", "seminar_abstract": "Axons degenerate before the neuronal soma in many neurodegenerative diseases. Programmed axon death (Wallerian degeneration) is a widely-occurring mechanism of axon loss that is well understood and preventable in animals. Its aberrant activation by mutation of the pro-survival gene Nmnat2 directly causes axonopathy in mice with severity ranging from mild polyneuropathy to perinatal lethality. Rare biallelic mutations in the homologous human gene cause related phenotypes in patients. NMNAT2 is a negative regulator of the prodegenerative NADase SARM1. Constitutive activation of SARM1 is cytotoxic and the human SARM1 locus is significantly associated with sporadic ALS. Another negative regulator, STMN2, has also been implicated in ALS, where it is commonly depleted downstream of TDP-43. In mice, programmed axon death can be robustly blocked by deletion of Sarm1, or by overexpression, axonal targeting and/or stabilization of various NMNAT isoforms. This alleviates models of many human disorders including some forms of peripheral neuropathy, motor neuron diseases, glaucoma, Parkinson\u2019s disease and traumatic brain injury, and it confers lifelong rescue on the lethal Nmnat2 null phenotype and other conditions. Drug discovery programs now aim to achieve similar outcomes in human disease. In order to optimize the use of such drugs, we have characterized a range of human NMNAT2 and SARM1 functional variants that underlie a spectrum of axon vulnerability in the human population. Individuals at the vulnerable end of this spectrum are those most likely to benefit from drugs blocking programmed axon death, and disorders associated with these genotypes are promising indications in which to apply them.", "hosted_by": "McGill Killam Neuro", "domain": ["Neuroscience"], "calendar_event_hash": "6eae4eedfa1e21b436b4d9f3908668fc1ed641d3692cf4dea25a2f3ddd1cd71b", "seminar_id": 1157, "time_of_addition": "Mon, Oct 05, 2020 18:25"}, "810": {"seminar_date": "Tue, Mar 17, 2020", "seminar_time": "12:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://zoom.us/j/7644908050", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Ethan M. Goldberg, MD, PhD", "speaker_affil": "The Children's Hospital of Philadelphia", "speaker_twitter": "@Go3than", "speaker_website": "http://goldbergneurolab.com/", "topic_tags": "disease", "seminar_title": "Cellular/circuit dysfunction in a model of Dravet syndrome - a severe childhood epilepsy", "seminar_abstract": "Dravet syndrome is a severe childhood epilepsy due to heterozygous loss-of-function mutation of the gene SCN1A, which encodes the type 1 neuronal voltage gated sodium (Na+) channel alpha-subunit Nav1.1. Prior studies in mouse models of Dravet syndrome (Scn1a+/- mice) at early developmental time points indicate that, in cerebral cortex, Nav1.1 is predominantly expressed in GABAergic interneurons (INs) and, in particular, in parvalbumin-positive fast-spiking basket cells (PV-INs). This has led to a model of Dravet syndrome pathogenesis whereby Nav1.1 mutation leads to preferential IN dysfunction, decreased synaptic inhibition, hyperexcitability, and epilepsy. We found that, at later developmental time points, the intrinsic excitability of PV-INs has essentially normalized, via compensatory reorganization of axonal Na+ channels. Instead, we found persistent and seemingly paradoxical dysfunction of putative disinhibitory INs expressing vasoactive intestinal peptide (VIP-INs). In vivo two-photon calcium imaging in neocortex during temperature-induced seizures in Scn1a+/- mice showed that mean activity of both putative principal cells and PV-INs was higher in Scn1a+/- relative to wild-type controls during quiet wakefulness at baseline and at elevated core body temperature. However, wild-type PV-INs showed a progressive synchronization in response to temperature elevation that was absent in PV-INs from Scn1a+/- mice immediately prior to seizure onset. We suggest that impaired PV-IN synchronization, perhaps via persistent axonal dysfunction, may contribute to the transition to the ictal state during temperature induced seizures in Dravet syndrome.", "hosted_by": "The Neurotheory Forum", "domain": ["Neuroscience"], "calendar_event_hash": "97cdc53b45485ce3c58bb27253be9b19fb0757c961ff1ca60344c93a33f9d3cd", "seminar_id": 810, "time_of_addition": "Mon, Sep 28, 2020 11:06"}, "811": {"seminar_date": "Wed, Mar 18, 2020", "seminar_time": "13:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://zoom.us/j/7644908050", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Penelope Lewis", "speaker_affil": "Cardiff University Brain Research Imaging Centre", "speaker_twitter": "", "speaker_website": "https://www.cardiff.ac.uk/people/view/899153-lewis-penny-penelope.com/", "topic_tags": "theory, cognitive", "seminar_title": "Sleep, semantic memory, and creative problem solving", "seminar_abstract": "Creative thought relies on the reorganisation of existing knowledge. Sleep is known to be important for creative thinking, but there is a debate about which sleep stage is most relevant, and why. I will address this issue by proposing that Rapid Eye Movement sleep, or 'REM', and Non-REM sleep facilitate creativity in different ways. Memory replay mechanisms in Non-REM can abstract rules from corpuses of learned information, while replay in REM may promote novel associations. I propose that the iterative interleaving of REM and Non-REM across a night boosts the formation of complex knowledge frameworks, and allows these frameworks to be restructured - thus facilitating creative thought. My talk will discuss experiments exploring these hypotheses, and the mechanisms for these processes.", "hosted_by": "The Neurotheory Forum", "domain": ["Neuroscience"], "calendar_event_hash": "75818060ff720132eaf094788b3cadce8338f645b991ef9aaa9b130b79543762", "seminar_id": 811, "time_of_addition": "Mon, Sep 28, 2020 11:06"}, "812": {"seminar_date": "Fri, Apr 3, 2020", "seminar_time": "14:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://zoom.us/j/142346841", "password": "1952", "video_on_demand": "https://youtu.be/vQ-1sVetzN4", "speaker_title": "Prof", "seminar_speaker": "Blake Richards", "speaker_affil": "McGill University", "speaker_twitter": "@tyrell_turing", "speaker_website": "https://mila.quebec/en/person/blake-richards/", "topic_tags": "theory", "seminar_title": "Burst-dependent synaptic plasticity can coordinate learning in hierarchical circuits", "seminar_abstract": "Synaptic plasticity is believed to be a key physiological mechanism for learning. It is well-established that it depends on pre and postsynaptic activity. However, models that rely solely on pre and postsynaptic activity for synaptic changes have, to date, not been able to account for learning complex tasks that demand hierarchical networks. Here, we show that if synaptic plasticity is regulated by high-frequency bursts of spikes, then neurons higher in the hierarchy can coordinate the plasticity of lower-level connections. Using simulations and mathematical analyses, we demonstrate that, when paired with short-term synaptic dynamics, regenerative activity in the apical dendrites, and synaptic plasticity in feedback pathways, a burst-dependent learning rule can solve challenging tasks that require deep network architectures. Our results demonstrate that well-known properties of dendrites, synapses, and synaptic plasticity are sufficient to enable sophisticated learning in hierarchical circuits.", "hosted_by": "The Neurotheory Forum", "domain": ["Neuroscience"], "calendar_event_hash": "898749bd93fd24a8b0f88314a602a20bce9138868cfc3983e76406709188ef9e", "seminar_id": 812, "time_of_addition": "Mon, Sep 28, 2020 11:06"}, "813": {"seminar_date": "Wed, Apr 8, 2020", "seminar_time": "14:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://zoom.us/j/708168938", "password": "1952", "video_on_demand": "https://youtu.be/tDtZ90CHI7o", "speaker_title": "Prof", "seminar_speaker": "Kanaka Rajan", "speaker_affil": "Icahn School of Medicine at Mount Sinai", "speaker_twitter": "@rajankdr", "speaker_website": "https://www.rajanlab.com/", "topic_tags": "theory", "seminar_title": "Recurrent network models of adaptive and maladaptive learning", "seminar_abstract": "During periods of persistent and inescapable stress, animals can switch from active to passive coping strategies to manage effort-expenditure. Such normally adaptive behavioural state transitions can become maladaptive in disorders such as depression. We developed a new class of multi-region recurrent neural network (RNN) models to infer brain-wide interactions driving such maladaptive behaviour. The models were trained to match experimental data across two levels simultaneously: brain-wide neural dynamics from 10-40,000 neurons and the realtime behaviour of the fish. Analysis of the trained RNN models revealed a specific change in inter-area connectivity between the habenula (Hb) and raphe nucleus during the transition into passivity. We then characterized the multi-region neural dynamics underlying this transition. Using the interaction weights derived from the RNN models, we calculated the input currents from different brain regions to each Hb neuron. We then computed neural manifolds spanning these input currents across all Hb neurons to define subspaces within the Hb activity that captured communication with each other brain region independently. At the onset of stress, there was an immediate response within the Hb/raphe subspace alone. However, RNN models identified no early or fast-timescale change in the strengths of interactions between these regions. As the animal lapsed into passivity, the responses within the Hb/raphe subspace decreased, accompanied by a concomitant change in the interactions between the raphe and Hb inferred from the RNN weights. This innovative combination of network modeling and neural dynamics analysis points to dual mechanisms with distinct timescales driving the behavioural state transition: early response to stress is mediated by reshaping the neural dynamics within a preserved network architecture, while long-term state changes correspond to altered connectivity between neural ensembles in distinct brain regions.", "hosted_by": "The Neurotheory Forum", "domain": ["Neuroscience"], "calendar_event_hash": "eb81ba08f3baf84fe4dd30388329dd511241eb763d8a3a30c4bcc0c36809ceec", "seminar_id": 813, "time_of_addition": "Mon, Sep 28, 2020 11:06"}, "814": {"seminar_date": "Thu, Apr 23, 2020", "seminar_time": "16:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/denis-jabaudons-world", "password": "", "video_on_demand": "https://www.youtube.com/watch?v=YgEPbp0JwKA", "speaker_title": "Prof", "seminar_speaker": "Denis Jabaudon", "speaker_affil": "University of Geneva", "speaker_twitter": "@denisjabaudon", "speaker_website": "https://neurocenter-unige.ch/research-groups/denis-jabaudon/", "topic_tags": "development", "seminar_title": "Fate and freedom in developing neocortical circuits", "seminar_abstract": "During brain development, neurons are born in specialized niches and migrate to target regions where they assemble to form the circuits that underlie mammalian behaviour. During their journey, neurons follow cell-intrinsic, genetic programs transmitted by their mother cells but also environmental cues, which together drive their maturation. Here, focusing on the neocortex, I will discuss recent findings from our laboratory in which we untangle and manipulate the programs at play in progenitors and their daughter neurons to better understand the emergence of cellular diversity in the developing brain.", "hosted_by": "The Neurotheory Forum", "domain": ["Neuroscience"], "calendar_event_hash": "8a0c5cb9832bc61128b21bdca741572a1525c3d475216dc71d478388c999ff8b", "seminar_id": 814, "time_of_addition": "Mon, Sep 28, 2020 11:06"}, "815": {"seminar_date": "Wed, Apr 15, 2020", "seminar_time": "14:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://zoom.us/j/246868898", "password": "1952", "video_on_demand": "https://youtu.be/cScVJffcFko", "speaker_title": "Prof", "seminar_speaker": "Andre Longtin", "speaker_affil": "University of Ottawa", "speaker_twitter": "", "speaker_website": "https://mysite.science.uottawa.ca/alongtin/", "topic_tags": "theory, electrophysiology", "seminar_title": "Inferring Brain Rhythm Circuitry and Burstiness", "seminar_abstract": "Bursts in gamma and other frequency ranges are thought to contribute to the efficiency of working memory or communication tasks. Abnormalities in bursts have also been associated with motor and psychiatric disorders. The determinants of burst generation are not known, specifically how single cell and connectivity parameters influence burst statistics and the corresponding brain states.  We first present a generic mathematical model for burst generation in an excitatory-inhibitory (EI) network with self-couplings. The resulting equations for the stochastic phase and envelope of the rhythm\u2019s fluctuations are shown to depend on only two meta-parameters that combine all the network parameters. They allow us to identify different regimes of amplitude excursions, and to highlight the supportive role that network finite-size effects and noisy inputs to the EI network can have. We discuss how burst attributes, such as their durations and peak frequency content, depend on the network parameters.  In practice, the problem above follows the a priori challenge of fitting such E-I spiking networks to single neuron or population data. Thus, the second part of the talk will discuss a novel method to fit mesoscale dynamics using single neuron data along with a low-dimensional, and hence statistically tractable, single neuron model. The mesoscopic representation is obtained by approximating a population of neurons as multiple homogeneous \u2018pools\u2019 of neurons, and modelling the dynamics of the aggregate population activity within each pool. We derive the likelihood of both single-neuron and connectivity parameters given this activity, which can then be used to either optimize parameters by gradient ascent on the log-likelihood, or to perform Bayesian inference using Markov Chain Monte Carlo (MCMC) sampling. We illustrate this approach using an E-I network of generalized integrate-and-fire neurons for which mesoscopic dynamics have been previously derived. We show that both single-neuron and connectivity parameters can be adequately recovered from simulated data.", "hosted_by": "The Neurotheory Forum", "domain": ["Neuroscience"], "calendar_event_hash": "a9ef01f37f5306847922baffb0d613d0b3ad4d895e5250752807b7c616469a30", "seminar_id": 815, "time_of_addition": "Mon, Sep 28, 2020 11:06"}, "816": {"seminar_date": "Wed, Apr 29, 2020", "seminar_time": "14:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/sara-sollas-world-wide", "password": "", "video_on_demand": "https://www.crowdcast.io/e/sara-sollas-world-wide", "speaker_title": "Prof", "seminar_speaker": "Sara Solla", "speaker_affil": "Northwestern University", "speaker_twitter": "@SaraASolla", "speaker_website": "https://www.feinberg.northwestern.edu/faculty-profiles/az/profile.html?xid=16584", "topic_tags": "theory, dynamical systems", "seminar_title": "Neural manifolds for the stable control of movement", "seminar_abstract": "Animals perform learned actions with remarkable consistency for years after acquiring a skill. What is the neural correlate of this stability? We explore this question from the perspective of neural populations. Recent work suggests that the building blocks of neural function may be the activation of population-wide activity patterns: neural modes that capture the dominant co-variation patterns of population activity and define a task specific low dimensional neural manifold. The time-dependent activation of the neural modes results in latent dynamics. We hypothesize that the latent dynamics associated with the consistent execution of a behaviour need to remain stable, and use an alignment method to establish this stability. Once identified, stable latent dynamics allow for the prediction of various behavioural features via fixed decoder models. We conclude that latent cortical dynamics within the task manifold are the fundamental and stable building blocks underlying consistent behaviour.", "hosted_by": "The Neurotheory Forum", "domain": ["Neuroscience"], "calendar_event_hash": "32097b4262ab3d91d13e5fe932b2b31a1cfadab57ce3c779eff9615ec9b43059", "seminar_id": 816, "time_of_addition": "Mon, Sep 28, 2020 11:06"}, "817": {"seminar_date": "Fri, May 8, 2020", "seminar_time": "14:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/xaq-pitkows-world-wide", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Xaq Pitkow", "speaker_affil": "Baylor College of Medicine & Rice University", "speaker_twitter": "@xaqlab", "speaker_website": "https://xaqlab.com", "topic_tags": "theory, bayes, uncertainty", "seminar_title": "Rational thoughts in neural codes", "seminar_abstract": "First, we describe a new method for inferring the mental model of an animal performing a natural task. We use probabilistic methods to compute the most likely mental model based on an animal\u2019s sensory observations and actions. This also reveals dynamic beliefs that would be optimal according to the animal\u2019s internal model, and thus provides a practical notion of \u201crational thoughts.\u201d Second, we construct a neural coding framework by which these rational thoughts, their computational dynamics, and actions can be identified within the manifold of neural activity. We illustrate the value of this approach by training an artificial neural network to perform a generalization of a widely used foraging task. We analyze the network\u2019s behaviour to find rational thoughts, and successfully recover the neural properties that implemented those thoughts, providing a way of interpreting the complex neural dynamics of the artificial brain.  Joint work with Zhengwei Wu, Minhae Kwon, Saurabh Daptardar, and Paul Schrater.", "hosted_by": "The Neurotheory Forum", "domain": ["Neuroscience"], "calendar_event_hash": "2ebbfc3c8d8441ca163e202d047c77c568fd8179d784c741bbb2588fbee62e24", "seminar_id": 817, "time_of_addition": "Mon, Sep 28, 2020 11:06"}, "818": {"seminar_date": "Fri, May 15, 2020", "seminar_time": "14:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/daniela-vallentins-world", "password": "", "video_on_demand": "https://youtu.be/sqvc2eXtsoA", "speaker_title": "Dr", "seminar_speaker": "Daniela Vallentin", "speaker_affil": "Max Planck Institute for Ornithology", "speaker_twitter": "@LabVallentin", "speaker_website": "https://vallentinlab.com", "topic_tags": "behaviour, electrophysiology, birdsong", "seminar_title": "Neural control of vocal interactions in songbirds", "seminar_abstract": "During conversations we rapidly switch between listening and speaking which often requires withholding or delaying our speech in order to hear others and avoid overlapping. This capacity for vocal turn-taking is exhibited by non-linguistic species as well, however the neural circuit mechanisms that enable us to regulate the precise timing of our vocalizations during interactions are unknown. We aim to identify the neural mechanisms underlying the coordination of vocal interactions. Therefore, we paired zebra finches with a vocal robot (1Hz call playback) and measured the bird\u2019s call response times. We found that individual birds called with a stereotyped delay in respect to the robot call. Pharmacological inactivation of the premotor nucleus HVC revealed its necessity for the temporal coordination of calls. We further investigated the contributing neural activity within HVC by performing intracellular recordings from premotor neurons and inhibitory interneurons in calling zebra finches. We found that inhibition is preceding excitation before and during call onset. To test whether inhibition guides call timing we pharmacologically limited the impact of inhibition on premotor neurons. As a result zebra finches converged on a similar delay time i.e. birds called more rapidly after the vocal robot call suggesting that HVC inhibitory interneurons regulate the coordination of social contact calls.  \n\nIn addition, we aim to investigate the vocal turn-taking capabilities of the common nightingale. Male nightingales learn over 100 different song motifs which are being used in order to attract mates or defend territories. Previously, it has been shown that nightingales counter-sing with each other following a similar temporal structure to human vocal turn-taking. These animals are also able to spontaneously imitate a motif of another nightingale. The neural mechanisms underlying this behaviour are not yet understood. In my lab, we further probe the capabilities of these animals in order to access the dynamic range of their vocal turn taking flexibility.", "hosted_by": "The Neurotheory Forum", "domain": ["Neuroscience"], "calendar_event_hash": "00a9b2c3238f1a3d6ed7750b559ddf0d8c82e42ad87ad7af37d9110ac91594bd", "seminar_id": 818, "time_of_addition": "Mon, Sep 28, 2020 11:06"}, "819": {"seminar_date": "Fri, May 22, 2020", "seminar_time": "14:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/anne-marie-oswalds-world", "password": "", "video_on_demand": "https://youtu.be/Ijx-HzcGAUE", "speaker_title": "Prof", "seminar_speaker": "Ann-Marie Oswald", "speaker_affil": "University of Pitsburgh", "speaker_twitter": "", "speaker_website": "http://www.ammoswald.com/", "topic_tags": "theory, electrophysiology", "seminar_title": "Circuit and synaptic mechanisms of plasticity in neural ensembles", "seminar_abstract": "Inhibitory microcircuits play an important role regulating cortical responses to sensory stimuli. Interneurons that inhibit dendritic or somatic integration are gatekeepers for neural activity, synaptic plasticity and the formation of sensory representations. We have been investigating the synaptic plasticity mechanisms underlying the formation of ensembles in olfactory and orbitofrontal cortex. We have been focusing on the roles of three inhibitory neuron classes in gating excitatory synaptic plasticity in olfactory cortex- somatostatin (SST-INs), parvalbumin (PV-INs), and vasoactive intestinal polypeptide (VIP-INs) interneurons. Further, we are investigating the rules for inhibitory plasticity and a potential role in stabilizing ensembles in associative cortices. I will present new findings to support distinct roles for different interneuron classes in the gating and stabilization of ensemble representations of olfactory responses.", "hosted_by": "The Neurotheory Forum", "domain": ["Neuroscience"], "calendar_event_hash": "4ec5abc2a097a8d76395cb073bd2baa4366559b3e82107346912719e5ed21639", "seminar_id": 819, "time_of_addition": "Mon, Sep 28, 2020 11:06"}, "820": {"seminar_date": "Fri, May 29, 2020", "seminar_time": "14:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/upinder-singh-bhallas", "password": "", "video_on_demand": "https://youtu.be/FJDXa54OqgA", "speaker_title": "Prof", "seminar_speaker": "Upinder Singh Bhalla", "speaker_affil": "National Centre for Biological Sciences of the Tata Institute of Fundamental Research.", "speaker_twitter": "@bhalla_lab", "speaker_website": "https://www.ncbs.res.in/faculty/bhalla", "topic_tags": "theory, electrophysiology", "seminar_title": "The butterfly strikes back: neurons doing 'network' computation", "seminar_abstract": "We live in the age of the network: Internet social neural ecosystems. This has become one of the main metaphors for how we think about complex systems. This view also dominates the account of brain function. The role of neuronsdescribed by Cajal as the \"butterflies of the soul\" has become diminished to leaky integrate-and-fire point objects in many models of neural network computation. It is perhaps not surprising that networkexplanations of neural phenomena use neurons as elementary particles andascribe all their wonderful capabilities to their interactions in a network. In the network view the Connectome defines the brain and the butterflies have no role. In this talk I'd like to reclaim some key computations from the networkand return them to their rightful place at the cellular and subcellular level. I'll start with a provocative look at potential computational capacity ofdifferent kinds of brain computation: network vs. subcellular. I'll then consider different levels of pattern and sequence computationwith a glimpse of the efficiency of the subcellular solutions. Finally I propose that there is a suggestive mapping between entire nodesof deep networks to individual neurons. This in my view is how we can walk around with 1.3 litres and 20 watts of installed computational capacity still doing far more than giant AI server farms.", "hosted_by": "The Neurotheory Forum", "domain": ["Neuroscience"], "calendar_event_hash": "46577575dd4f514fc9e01e0c0ebf0e1f8fb47048699976ba6707716a1b66e5aa", "seminar_id": 820, "time_of_addition": "Mon, Sep 28, 2020 11:06"}, "821": {"seminar_date": "Fri, Jun 5, 2020", "seminar_time": "9:00", "timezone": "America/Los_Angeles", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/kay-tyes-world-wide", "password": "", "video_on_demand": "https://www.crowdcast.io/e/kay-tyes-world-wide", "speaker_title": "Prof", "seminar_speaker": "Kay Tye", "speaker_affil": "University of California, San Diego", "speaker_twitter": "@kaymtye", "speaker_website": "https://www.salk.edu/scientist/kay-tye/", "topic_tags": "electrophysiology, echem, pharmacology, optogenetics", "seminar_title": "Neural Circuit Mechanisms of Emotional and Social Processing", "seminar_abstract": "How does our brain rapidly determine if something is good or bad? How do we know our place within a social group? How do we know how to behave appropriately in dynamic environments with ever-changing conditions?  The Tye Lab is interested in understanding how neural circuits important for driving positive and negative motivational valence (seeking pleasure or avoiding punishment) are anatomically, genetically and functionally arranged. We study the neural mechanisms that underlie a wide range of behaviours ranging from learned to innate, including social, feeding, reward-seeking and anxiety-related behaviours. We have also become interested in \u201csocial homeostasis\u201d -- how our brains establish a preferred set-point for social contact, and how this maintains stability within a social group. How are these circuits interconnected with one another, and how are competing mechanisms orchestrated on a neural population level? We employ optogenetic, electrophysiological, electrochemical, pharmacological and imaging approaches to probe these circuits during behaviour.", "hosted_by": "The Neurotheory Forum", "domain": ["Neuroscience"], "calendar_event_hash": "8f8921cc46817b163db13015cbeadd4e4c14e7597697ad6a47ca2a3d6f20310b", "seminar_id": 821, "time_of_addition": "Mon, Sep 28, 2020 11:06"}, "822": {"seminar_date": "Mon, Jun 8, 2020", "seminar_time": "14:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/mat-lengyels-world-wide", "password": "", "video_on_demand": "https://www.crowdcast.io/e/mat-lengyels-world-wide", "speaker_title": "Prof", "seminar_speaker": "M\u00e1t\u00e9 Lengyel", "speaker_affil": "University of Cambridge", "speaker_twitter": "", "speaker_website": "https://www.neuroscience.cam.ac.uk/directory/profile.php?lmate", "topic_tags": "theory", "seminar_title": "Cortical-like dynamics in recurrent circuits optimized for sampling-based probabilistic inference", "seminar_abstract": "Sensory cortices display a suite of ubiquitous dynamical features, such as ongoing noise variability, transient overshoots, and oscillations, that have so far escaped a common, principled theoretical account. We developed a unifying model for these phenomena by training a recurrent excitatory-inhibitory neural circuit model of a visual cortical hypercolumn to perform sampling-based probabilistic inference. The optimized network displayed several key biological properties, including divisive normalization, as well as stimulus-modulated noise variability, inhibition-dominated transients at stimulus onset, and strong gamma oscillations. These dynamical features had distinct functional roles in speeding up inferences and made predictions that we confirmed in novel analyses of awake monkey recordings. Our results suggest that the basic motifs of cortical dynamics emerge as a consequence of the efficient implementation of the same computational function \u2014 fast sampling-based inference \u2014 and predict further properties of these motifs that can be tested in future experiments", "hosted_by": "The Neurotheory Forum", "domain": ["Neuroscience"], "calendar_event_hash": "5de314070bac666b5ae45e72f577bddd4bb1cc3b1565d970d6028af1508ca481", "seminar_id": 822, "time_of_addition": "Mon, Sep 28, 2020 11:06"}, "823": {"seminar_date": "Fri, Jun 12, 2020", "seminar_time": "14:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/timothy-lillicraps-world", "password": "", "video_on_demand": "https://www.pscp.tv/w/cbJDpjFvUEtMeEFBTnlKS2R8MW1uR2VsTGpvQldLWFwvGwMot8Nl98F_AOzhEBnrepyQ3K0ZVlmYSbPn2H6u?t=43s", "speaker_title": "Prof", "seminar_speaker": "Timothy Lillicrap", "speaker_affil": "Google Deep Mind, University College London", "speaker_twitter": "", "speaker_website": "http://contrastiveconvergence.net/~timothylillicrap/index.php", "topic_tags": "theory, ML", "seminar_title": "Deep learning for model-based RL", "seminar_abstract": "Model-based approaches to control and decision making have long held the promise of being more powerful and data efficient than model-free counterparts. However, success with model-based methods has been limited to those cases where a perfect model can be queried. The game of Go was mastered by AlphaGo using a combination of neural networks and the MCTS planning algorithm. But planning required a perfect representation of the game rules. I will describe new algorithms that instead leverage deep neural networks to learn models of the environment which are then used to plan, and update policy and value functions. These new algorithms offer hints about how brains might approach planning and acting in complex environments.", "hosted_by": "The Neurotheory Forum", "domain": ["Neuroscience"], "calendar_event_hash": "9d762676b2428a02b9812c8bc7bd9c341782e4f1d6fe6e4251830ca6295f2426", "seminar_id": 823, "time_of_addition": "Mon, Sep 28, 2020 11:06"}, "824": {"seminar_date": "Fri, Jun 19, 2020", "seminar_time": "14:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/srdjan-ostojics-world", "password": "", "video_on_demand": "https://www.crowdcast.io/e/srdjan-ostojics-world", "speaker_title": "Dr.", "seminar_speaker": "Srdjan Ostojic", "speaker_affil": "\u00c9cole Normale Sup\u00e9rieure", "speaker_twitter": "@ostojic_srdjan", "speaker_website": "https://lnc2.dec.ens.fr/en/member/655/srdjan-ostojic", "topic_tags": "theory", "seminar_title": "Disentangling the roles of dimensionality and cell categories in neural computations", "seminar_abstract": "The description of neural computations currently relies on two competing views: (i) a classical single-cell view that aims to relate the activity of individual neurons to sensory or behavioural variables, and organize them into functional classes; (ii) a more recent population view that instead characterises computations in terms of collective neural trajectories, and focuses on the dimensionality of these trajectories as animals perform tasks. How the two key concepts of functional cell classes and low-dimensional trajectories interact to shape neural computations is however at present not understood. Here I will address this question by combining machine-learning tools for training recurrent neural networks with reverse-engineering and theoretical analyses of network dynamics.", "hosted_by": "The Neurotheory Forum", "domain": ["Neuroscience"], "calendar_event_hash": "f0c27080c5a0413a00176c830c1c2493e00a3e93df8458acbc321498f55a9b2f", "seminar_id": 824, "time_of_addition": "Mon, Sep 28, 2020 11:06"}, "825": {"seminar_date": "Wed, Jun 24, 2020", "seminar_time": "14:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/lenka-zdeborov", "password": "", "video_on_demand": "https://youtu.be/1wXmaCbujMQ", "speaker_title": "Dr", "seminar_speaker": "Lenka Zdeborov\u00e1", "speaker_affil": "CNRS & CEA Saclay", "speaker_twitter": "@zdeborova", "speaker_website": "http://artax.karlin.mff.cuni.cz/~zdebl9am/", "topic_tags": "theory, ML", "seminar_title": "Understanding machine learning via exactly solvable statistical physics models", "seminar_abstract": "The affinity between statistical physics and machine learning has long history, this is reflected even in the machine learning terminology that is in part adopted from physics. I will describe the main lines of this long-lasting friendship in the context of current theoretical challenges and open questions about deep learning. Theoretical physics often proceeds in terms of solvable synthetic models, I will describe the related line of work on solvable models of simple feed-forward neural networks. I will highlight a path forward to capture the subtle interplay between the structure of the data, the architecture of the network, and the learning algorithm.", "hosted_by": "The Neurotheory Forum", "domain": ["Neuroscience"], "calendar_event_hash": "a168ec4a9a72c938731051849ef363149ec913380786e1f142e1510348136b4b", "seminar_id": 825, "time_of_addition": "Mon, Sep 28, 2020 11:06"}, "826": {"seminar_date": "Fri, Jun 26, 2020", "seminar_time": "14:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/annegret-falkners-world", "password": "", "video_on_demand": "https://www.crowdcast.io/e/annegret-falkners-world", "speaker_title": "Prof", "seminar_speaker": "Annegret Falkner", "speaker_affil": "Princeton University", "speaker_twitter": "@Neurrriot", "speaker_website": "https://www.falknerlab.com/", "topic_tags": "behaviour, electrophysiology", "seminar_title": "Mapping the neural dynamics of social dominance and defeat", "seminar_abstract": "", "hosted_by": "The Neurotheory Forum", "domain": ["Neuroscience"], "calendar_event_hash": "e6aa4af08c58cb449e6621e5d6178c5e99e0acb87e1d8010a90a420c05a6dc90", "seminar_id": 826, "time_of_addition": "Mon, Sep 28, 2020 11:06"}, "594": {"seminar_date": "Fri, Jul 3, 2020", "seminar_time": "14:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/moritz-helmstaedters", "password": "", "video_on_demand": "https://youtu.be/CNWOF-5NZOU", "speaker_title": "Prof", "seminar_speaker": "Moritz Helmstaedter", "speaker_affil": "Max Planck Institute for Brain Research", "speaker_twitter": "@mh_lab", "speaker_website": "https://brain.mpg.de/research/helmstaedter-department/director.html", "topic_tags": "connectome, cortex", "seminar_title": "Cerebral Cortex Connectomics", "seminar_abstract": "Densely mapping neuronal circuits at synaptic resolution is providing unprecedented insight into the formation and structure of the cerebral cortex. I\u2019ll present recent advances and discuss what we can learn about precision, plasticity and possible patterns in mammalian neuronal circuits.", "hosted_by": "The Neurotheory Forum", "domain": ["Neuroscience"], "calendar_event_hash": "28e552c429105735de84bdeb9eb1d07467951d0c2f3c6f6e54989b12aaedb50e", "seminar_id": 594, "time_of_addition": "Mon, Sep 07, 2020 16:45"}, "827": {"seminar_date": "Fri, Jul 10, 2020", "seminar_time": "14:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/philip-berenss-world", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Philipp Berens", "speaker_affil": "University of T\u00fcbingen", "speaker_twitter": "@CellTypist", "speaker_website": "http://www.eye-tuebingen.de/berens/", "topic_tags": "theory, ML, retina, vision", "seminar_title": "Towards hybrid models of retinal circuits - integrating biophysical realism, anatomical constraints and predictive performance", "seminar_abstract": "Visual processing in the retina has been studied in great detail at all levels such that a comprehensive picture of the retina's cell types and the many neural circuits they form is emerging. However, the currently best performing models of retinal function are black-box CNN models which are agnostic to such biological knowledge. Here, I present two of our recent attempts to develop computational models of processing in the inner retina, which both respect biophysical and anatomical constraints yet provide accurate predictions of retinal activity", "hosted_by": "The Neurotheory Forum", "domain": ["Neuroscience"], "calendar_event_hash": "d377fd1f0aeb9f145dbbee27885a33c4bf08b8c6138ae55f29b370ccfc471108", "seminar_id": 827, "time_of_addition": "Mon, Sep 28, 2020 11:06"}, "828": {"seminar_date": "Wed, Jul 8, 2020", "seminar_time": "14:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/oxford-neurotheory-prof-", "password": "", "video_on_demand": "https://www.youtube.com/watch?v=yyBsqzy6QUo", "speaker_title": "Prof", "seminar_speaker": "Linda Smith", "speaker_affil": "Indiana University", "speaker_twitter": "", "speaker_website": "https://cogdev.sitehost.iu.edu/", "topic_tags": "theory, devpsych", "seminar_title": "Learning from the infant\u2019s point of view", "seminar_abstract": "Learning depends on both the learning mechanism and the regularities in the training material, yet most research on human and machine learning focus on the discovering the mechanisms that underlie powerful learning. I will present evidence from our research focusing on the statistical structure of infant visual learning environments. The findings suggest that the statistical structure of those learning environments are not like those used in laboratory experiments on visual learning, in machine learning, or in our adult assumptions about how teach visual categories. The data derive from our use of head cameras and head-mounted eye trackers capturing FOV experiences in the home as well as in simulated home environments in the laboratory. The participants range from 1 month of age to 24 months. The observed statistical structure offers new insights into the developmental foundations of visual object recognition and suggest a computational rethinking of the problem of visual category formation. The observed environmental statistics also have direct implications for understanding the development of cortical visual systems.", "hosted_by": "The Neurotheory Forum", "domain": ["Neuroscience"], "calendar_event_hash": "88234446a386f178a12ab690537fbf37885cd7a8f121aeda93dd2078413e26cc", "seminar_id": 828, "time_of_addition": "Mon, Sep 28, 2020 11:06"}, "829": {"seminar_date": "Wed, Jul 29, 2020", "seminar_time": "14:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/nicolas-schuck--oxford", "password": "", "video_on_demand": "https://youtu.be/K7IPxeomcQ8", "speaker_title": "Dr", "seminar_speaker": "Nicolas Schuck", "speaker_affil": "MPI Berlin", "speaker_twitter": "@nico_schuck", "speaker_website": "https://schucklab.gitlab.io/", "topic_tags": "theory, cognitive", "seminar_title": "Distributed replay in the human brain, and how to find it", "seminar_abstract": "I will present work on a novel fMRI analysis method that allows us to investigate sequential reactivation in the hippocampus. Our method focuses on analysing the time courses of probabilistic multivariate classifiers and allows us to infer the presence and frequency of fast sequential reactivation events. Using a paradigm in which we controlled the speed of sequential visually elicited activations, we validated the method in visual cortex for event sequences with only 32 ms between items. We show that detectability remains possible if low signal-to-noise ratio and when sequence events occur at unknown times. In a preliminary analysis, we show that even the exposure to our visual paradigm elicits reactivations in visual cortex at rest following the task. I then present work in which we tested how representations influence replay by asking whether transitions between task-state representations are reactivated at rest during hippocampal replay events. Participants learned to make decisions about ambiguous stimuli that depended on past events and attentionally filtered stimulus processing. FMRI signals during rest periods following this task indicated sequential reactivation of task states. These results indicate that adaptive task state representations are computed and replayed at different cortical sites. In combination with other methods, fMRI may allow us to unravel this coordinated nature of replay.", "hosted_by": "The Neurotheory Forum", "domain": ["Neuroscience"], "calendar_event_hash": "c4c58874586b8d595cb4a67f16ea6c7271f8774a0f8c530e5ba7d6b421ba5e6f", "seminar_id": 829, "time_of_addition": "Mon, Sep 28, 2020 11:06"}, "595": {"seminar_date": "Fri, Sep 11, 2020", "seminar_time": "15:00", "timezone": "Europe/Vienna", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/kenji-doyes", "password": "", "video_on_demand": "https://youtu.be/Bzwp3Cm0Kas", "speaker_title": "Prof", "seminar_speaker": "Kenji Doya", "speaker_affil": "Okinawa Institute of Science and Technology", "speaker_twitter": "", "speaker_website": "https://groups.oist.jp/ncu", "topic_tags": "theory, AI, ML, robots", "seminar_title": "What can we further learn from the brain for artificial intelligence?", "seminar_abstract": "Deep learning is a prime example of how brain-inspired computing can benefit development of artificial intelligence. But what else can we learn from the brain for bringing AI and robotics to the next level? Energy efficiency and data efficiency are the major features of the brain and human cognition that today\u2019s deep learning has yet to deliver. The brain can be seen as a multi-agent system of heterogeneous learners using different representations and algorithms. The flexible use of reactive, model-free control and model-based \u201cmental simulation\u201d appears to be the basis for computational and data efficiency of the brain. How the brain efficiently acquires and flexibly combines prediction and control modules is a major open problem in neuroscience and its solution should help developments of more flexible and autonomous AI and robotics.", "hosted_by": "The Neurotheory Forum", "domain": ["Neuroscience"], "calendar_event_hash": "b041e781a594c4e9237c5cd56ea43cdabe61dec1a60f9e915ea7e3b4fa9c2099", "seminar_id": 595, "time_of_addition": "Mon, Sep 07, 2020 21:30"}, "623": {"seminar_date": "Fri, Sep 18, 2020", "seminar_time": "15:00", "timezone": "Europe/Vienna", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/julijana-gjorgjievas", "password": "", "video_on_demand": "https://youtu.be/a7EeJD0y4zU", "speaker_title": "Prof", "seminar_speaker": "Julijana Gjorgjieva", "speaker_affil": "Max Planck Institute for Brain Research, Technical University of Munich", "speaker_twitter": "@GjorJulijana", "speaker_website": "http://cns.wzw.tum.de", "topic_tags": "theory, electrophysiology, dendrites, synapses, plasticity", "seminar_title": "Local and global organization of synaptic inputs on cortical dendrites", "seminar_abstract": "Synaptic inputs on cortical dendrites are organized with remarkable subcellular precision at the micron level. This organization emerges during early postnatal development through patterned spontaneous activity\u00a0and manifests both locally where synapses with similar functional properties are clustered, and globally along the axis from dendrite to soma. Recent experiments reveal species-specific differences in the local and\u00a0global synaptic organization in mouse, ferret and macaque visual cortex. I will present a computational framework that implements functional and structural plasticity from spontaneous activity patterns to generate\u00a0these different types of organization across species and scales. Within this framework, a single anatomical factor - the size of the visual cortex and the resulting magnification of visual space - can explain the\u00a0observed differences. This allows us to make predictions about the organization of synapses also in other species and indicates that the proximal-distal axis of a dendrite might be central in endowing a neuron with\u00a0powerful computational capabilities.", "hosted_by": "The Neurotheory Forum", "domain": ["Neuroscience"], "calendar_event_hash": "e11940e8b6a8e463ace62abfc46a7e5f0eadfb1ee9184032f1fd916fcf8c69e0", "seminar_id": 623, "time_of_addition": "Mon, Sep 07, 2020 23:25"}, "597": {"seminar_date": "Fri, Sep 25, 2020", "seminar_time": "15:00", "timezone": "Europe/Vienna", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/henning-sprekelers", "password": "", "video_on_demand": "https://youtu.be/xU-fNLfY3gY", "speaker_title": "Prof", "seminar_speaker": "Henning Sprekeler", "speaker_affil": "Technical University Berlin", "speaker_twitter": "@sprekeler", "speaker_website": "https://www.sprekelerlab.org", "topic_tags": "interneurons, theory", "seminar_title": "Self-organisation in interneuron circuits", "seminar_abstract": "Inhibitory interneurons come in different classes and form intricate circuits. While our knowledge of these circuits has advanced substantially over the last decades, it is not fully understood how the structure of these circuits relates to their function. I will present some of our recent attempts to \u201cunderstand\u201d the structure of interneuron circuits by means of computational modeling. Surprisingly (at least for us), we found that prominent features of inhibitory circuitry can be accounted for by an optimisation for excitation-inhibition (E/I) balance. In particular, we find that such an optimisation generates networks that resemble mouse V1 in terms of the structure of synaptic efficacies between principal cells and parvalbumin-positive interneurons. Moreover, an optimisation for E/I balance across neuronal compartments promotes a functional diversification of interneurons into two classes that resemble parvalbumin and somatostatin-positive interneurons. Time permitting, I may briefly touch on recent work in which we link E/I balance to prediction error coding in V1.", "hosted_by": "The Neurotheory Forum", "domain": ["Neuroscience"], "calendar_event_hash": "e7a405f3ce3edc71f19aadaeb2be94e8020eb4620b80ac277aeb14885f3b5153", "seminar_id": 597, "time_of_addition": "Mon, Sep 07, 2020 21:30"}, "598": {"seminar_date": "Fri, Oct 2, 2020", "seminar_time": "15:00", "timezone": "Europe/Vienna", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/venkat-ramaswamys", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Venkat Ramaswamy", "speaker_affil": "Birla Institute of Technology & Science", "speaker_twitter": "@VenkRamaswamy", "speaker_website": "https://theory.ncbs.res.in/vramaswamy/", "topic_tags": "neural circuits, neural computations, theory", "seminar_title": "An Algorithmic Barrier to Neural Circuit Understanding", "seminar_abstract": "Neuroscience is witnessing extraordinary progress in experimental techniques, especially at the neural circuit level. These advances are largely aimed at enabling us to understand precisely how neural circuit computations mechanistically cause behavior. Establishing this type of causal understanding will require multiple perturbational (e.g optogenetic) experiments. It has been unclear exactly how many such experiments are needed and how this number scales with the size of the nervous system in question. Here, using techniques from Theoretical Computer Science, we prove that establishing the most extensive notions of understanding need exponentially-many experiments in the number of neurons, in many cases, unless a widely-posited hypothesis about computation is false (i.e. unless P = NP). Furthermore, using data and estimates, we demonstrate that the feasible experimental regime is typically one where the number of experiments performable scales sub-linearly in the number of neurons in the nervous system. This remarkable gulf between the worst-case and the feasible suggests an algorithmic barrier to such an understanding. Determining which notions of understanding are algorithmically tractable to establish in what contexts, thus, becomes an important new direction for investigation. TL; DR: Non-existence of tractable algorithms for neural circuit interrogation could pose a barrier to comprehensively understanding how neural circuits cause behavior. Preprint: https://biorxiv.org/content/10.1101/639724v1/\u2026", "hosted_by": "The Neurotheory Forum", "domain": ["Neuroscience"], "calendar_event_hash": "c773d2cda860e2c27cba81d22fe982c5d9364c7b4fa651efbb3086115dfcbc50", "seminar_id": 598, "time_of_addition": "Mon, Sep 07, 2020 21:30"}, "1191": {"seminar_date": "Fri, Oct 16, 2020", "seminar_time": "15:00", "timezone": "Europe/Vienna", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/surya-gangulis", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Surya Ganguli", "speaker_affil": "Stanford University", "speaker_twitter": "@SuryaGanguli", "speaker_website": "http://ganguli-gang.stanford.edu/surya.html", "topic_tags": "", "seminar_title": "", "seminar_abstract": "", "hosted_by": "The Neurotheory Forum", "domain": ["Neuroscience"], "calendar_event_hash": "69c6ff7eb8a147242e2709690e55af2ad685ca1de759eeb151912a10b58b0ac0", "seminar_id": 1191, "time_of_addition": "Wed, Oct 07, 2020 12:10"}, "1192": {"seminar_date": "Fri, Oct 23, 2020", "seminar_time": "15:00", "timezone": "Europe/Vienna", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/anita-disneys", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Anita Disney", "speaker_affil": "Duke University School of Medicine", "speaker_twitter": "@neurodisney", "speaker_website": "https://www.neuro.duke.edu/research/faculty-labs/disney-lab", "topic_tags": "", "seminar_title": "Circuit mechanisms underlying the dynamic control of cortical processing by subcortical neuromodulators", "seminar_abstract": "Behavioral states such as arousal and attention can have profound effects on sensory processing, determining how \u2013 sometimes whether \u2013 a stimulus is processed. This state-dependence is believed to arise, at least in part, as a result of inputs to cortex from subcortical structures that release neuromodulators such as acetylcholine, noradrenaline, and serotonin, often non-synaptically. The mechanisms that underlie the interaction between these \u201cwireless\u201d non-synaptic signals and the \u201cwired\u201d cortical circuit are not well understood. Furthermore, neuromodulatory signaling is traditionally considered broad in its impact across cortex (within a species) and consistent in its form and function across species (at least in mammals). The work I will present approaches the challenge of understanding neuromodulatory action in the cortex from a number of angles: anatomy, physiology, pharmacology, and chemistry. The overarching goal of our effort is to elucidate the mechanisms behind local neuromodulation in the cortex of non-human primates, and to reveal differences in structure and function across cortical model systems.", "hosted_by": "The Neurotheory Forum", "domain": ["Neuroscience"], "calendar_event_hash": "6ed4ede5e9dbfaabc89b20c35c178d94205287de9c9a95c2ff0443700a646f35", "seminar_id": 1192, "time_of_addition": "Wed, Oct 07, 2020 12:10"}, "1193": {"seminar_date": "Fri, Nov 6, 2020", "seminar_time": "15:00", "timezone": "Europe/Vienna", "posted": "yes", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Megan Peters", "speaker_affil": "UC Irvine", "speaker_twitter": "@meganakpeters", "speaker_website": "https://faculty.sites.uci.edu/cnclab/", "topic_tags": "", "seminar_title": "", "seminar_abstract": "", "hosted_by": "The Neurotheory Forum", "domain": ["Neuroscience"], "calendar_event_hash": 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"password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Carina Curto", "speaker_affil": "Pennsylvania State University", "speaker_twitter": "", "speaker_website": "https://sites.psu.edu/mathneurolab/", "topic_tags": "", "seminar_title": "", "seminar_abstract": "", "hosted_by": "The Neurotheory Forum", "domain": ["Neuroscience"], "calendar_event_hash": "7964fb1a087bf21947943e198ecf1c0fdcbbde5ebe706d401676dd853160b180", "seminar_id": 1195, "time_of_addition": "Wed, Oct 07, 2020 12:10"}, "1196": {"seminar_date": "Fri, Dec 4, 2020", "seminar_time": "15:00", "timezone": "Europe/Vienna", "posted": "yes", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Valerio Mante", "speaker_affil": "ETH Zurich", "speaker_twitter": "@ValerioMante", "speaker_website": "https://www.ini.uzh.ch/en/research/groups/mante.html", "topic_tags": "", "seminar_title": "", "seminar_abstract": "", "hosted_by": "The Neurotheory Forum", "domain": ["Neuroscience"], "calendar_event_hash": "2151df5f79cd0dd23ca5b6d3afed7ec907d3c623efe526058de5112782cf3d87", "seminar_id": 1196, "time_of_addition": "Wed, Oct 07, 2020 12:10"}, "1197": {"seminar_date": "Fri, Dec 11, 2020", "seminar_time": "15:00", "timezone": "Europe/Vienna", "posted": "yes", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Ioana Carcea", "speaker_affil": "Rutgers University", "speaker_twitter": "@CarceaLab", "speaker_website": "http://www.carcealab.com/", "topic_tags": "", "seminar_title": "", "seminar_abstract": "", "hosted_by": "The Neurotheory Forum", "domain": ["Neuroscience"], "calendar_event_hash": "45add8e75bb17c8d2653396ec7dc0d6c0f688f00eaeef5ff426ad5a91a17612d", "seminar_id": 1197, "time_of_addition": "Wed, Oct 07, 2020 12:10"}, "1198": {"seminar_date": "Fri, Jan 15, 2021", "seminar_time": "15:00", "timezone": "Europe/Vienna", "posted": "yes", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Michele Insanally", "speaker_affil": "University of Pittsburgh School of Medicine", "speaker_twitter": "@InsanallyM", "speaker_website": "https://www.insanallylab.com/", "topic_tags": "", "seminar_title": "", "seminar_abstract": "", "hosted_by": "The Neurotheory Forum", "domain": ["Neuroscience"], "calendar_event_hash": "4839b261450a2a5732609a00244984a97be1af6897de09312835c01f65db5929", "seminar_id": 1198, "time_of_addition": "Wed, Oct 07, 2020 12:10"}, "1199": {"seminar_date": "Fri, Jan 22, 2021", "seminar_time": "15:00", "timezone": "Europe/Vienna", "posted": "yes", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Dan Goodman", "speaker_affil": "Imperial College London", "speaker_twitter": "@neuralreckoning", "speaker_website": "http://neural-reckoning.org/", "topic_tags": "", "seminar_title": "", "seminar_abstract": "", "hosted_by": "The Neurotheory Forum", "domain": ["Neuroscience"], "calendar_event_hash": "7d43f37d07db3fec1ca96a2fec96ecbb385e06c331e8bf64f541957f13c8a6d5", "seminar_id": 1199, "time_of_addition": "Wed, Oct 07, 2020 12:10"}, "1200": {"seminar_date": "Fri, Jan 29, 2021", "seminar_time": "15:00", "timezone": "Europe/Vienna", "posted": "yes", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Jeehyun Kwag", "speaker_affil": "Korea University", "speaker_twitter": "@jkwag_nclab", "speaker_website": "https://koreauniv.pure.elsevier.com/en/persons/jeehyun-kwag", "topic_tags": "", "seminar_title": "", "seminar_abstract": "", "hosted_by": "The Neurotheory Forum", "domain": ["Neuroscience"], "calendar_event_hash": "a0f35867dac2627e8282bc38903df6705958b15d7ac006ebcd941682420f8561", "seminar_id": 1200, "time_of_addition": "Wed, Oct 07, 2020 12:10"}, "1201": {"seminar_date": "Fri, Feb 12, 2021", "seminar_time": "15:00", "timezone": "Europe/Vienna", "posted": "yes", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "", "seminar_speaker": "Brad Wyble", "speaker_affil": "Pennsylvania State University", "speaker_twitter": "@bradpwyble", "speaker_website": "http://wyblelab.com/", "topic_tags": "", "seminar_title": "", "seminar_abstract": "", "hosted_by": "The Neurotheory Forum", "domain": ["Neuroscience"], "calendar_event_hash": "4038543ada032f68cf4667c4326c4e5ea059eca876ac01f0bb4ccad96cc293ba", "seminar_id": 1201, "time_of_addition": "Wed, Oct 07, 2020 12:10"}, "1202": {"seminar_date": "Fri, Feb 19, 2021", "seminar_time": "15:00", "timezone": "Europe/Vienna", "posted": "yes", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Inna Slutsky", "speaker_affil": "Tel Aviv University", "speaker_twitter": "@inna_slutsky", "speaker_website": "https://www.slutskylab.com/", "topic_tags": "", "seminar_title": "", "seminar_abstract": "", "hosted_by": "The Neurotheory Forum", "domain": 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"calendar_event_hash": "7d489e4c6691690d66415d02a70ec908ab359dab0a21717f72ce4a47cc90d2d0", "seminar_id": 1205, "time_of_addition": "Wed, Oct 07, 2020 12:10"}, "1206": {"seminar_date": "Fri, Mar 19, 2021", "seminar_time": "15:00", "timezone": "Europe/Vienna", "posted": "yes", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Ashok Litwin Kumar", "speaker_affil": "Columbia University", "speaker_twitter": "", "speaker_website": "http://lk.zuckermaninstitute.columbia.edu/index.shtml?", "topic_tags": "", "seminar_title": "", "seminar_abstract": "", "hosted_by": "The Neurotheory Forum", "domain": ["Neuroscience"], "calendar_event_hash": "dcefe86e99bbd45033ac0c202e70b66e671495bb7bd775c97d2a9cc9465e9477", "seminar_id": 1206, "time_of_addition": "Wed, Oct 07, 2020 12:10"}, "1207": {"seminar_date": "Fri, Apr 9, 2021", "seminar_time": "15:00", "timezone": "Europe/Vienna", "posted": "yes", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Tatyana Sharpee", "speaker_affil": "Salk Institute for Biological Studies", "speaker_twitter": "", "speaker_website": "https://www.salk.edu/scientist/tatyana-sharpee/", "topic_tags": "", "seminar_title": "", "seminar_abstract": "", "hosted_by": "The Neurotheory Forum", "domain": ["Neuroscience"], "calendar_event_hash": "303c9cb97bf6e7713fd2672110eb0617170c7287660a3435cd9cb07110f7f6c2", "seminar_id": 1207, "time_of_addition": "Wed, Oct 07, 2020 12:10"}, "1208": {"seminar_date": "Fri, Apr 16, 2021", "seminar_time": "15:00", "timezone": "Europe/Vienna", "posted": "yes", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "Dr", "seminar_speaker": "Kay Ayodele", "speaker_affil": "Obafemi Awolowo University", "speaker_twitter": "", "speaker_website": "http://eee.oauife.edu.ng/", "topic_tags": "", "seminar_title": "", "seminar_abstract": "", "hosted_by": "The Neurotheory Forum", "domain": ["Neuroscience"], "calendar_event_hash": "efe2255415d459f5b23476a8de733312b6f63cf9f7eacfe1ecc866a2e7b2c2a9", "seminar_id": 1208, "time_of_addition": "Wed, Oct 07, 2020 12:10"}, "1209": {"seminar_date": "Fri, Apr 23, 2021", "seminar_time": "15:00", "timezone": "Europe/Vienna", "posted": "yes", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Yiota Poirazi", "speaker_affil": "IMBB / FORTH", "speaker_twitter": "@YiotaPoirazi", "speaker_website": "http://www.dendrites.gr", "topic_tags": "", "seminar_title": "", "seminar_abstract": "", "hosted_by": "The Neurotheory Forum", "domain": ["Neuroscience"], "calendar_event_hash": "0f29025ad24bca512a51525c0d689bf65d5baf4e7a7698a2fb16ae2d2db64910", "seminar_id": 1209, "time_of_addition": "Wed, Oct 07, 2020 12:10"}, "1210": {"seminar_date": "Fri, Apr 30, 2021", "seminar_time": "15:00", "timezone": "Europe/Vienna", "posted": "yes", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Indira Raman", "speaker_affil": "Northwestern University", "speaker_twitter": "", "speaker_website": "https://www.neurobiology.northwestern.edu/people/core-faculty/indira-m-raman.html", "topic_tags": "", "seminar_title": "", "seminar_abstract": "", "hosted_by": "The Neurotheory Forum", "domain": ["Neuroscience"], "calendar_event_hash": "3fd26f63b7efe4d9d363af967c511ed1bfc364af098cfc322c2f911b54c1bb29", "seminar_id": 1210, "time_of_addition": "Wed, Oct 07, 2020 12:10"}, "1211": {"seminar_date": "Fri, May 7, 2021", "seminar_time": "15:00", "timezone": "Europe/Vienna", "posted": "yes", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Andr\u00e9 Fenton", "speaker_affil": "New York University", "speaker_twitter": "@aa_fenton", "speaker_website": "https://www.fentonlab.com/", "topic_tags": "", "seminar_title": "", "seminar_abstract": "", "hosted_by": "The Neurotheory Forum", "domain": ["Neuroscience"], "calendar_event_hash": "77664858f00912a2ac070775b48f3816bee7a1681fa125d3699465042ccdd305", "seminar_id": 1211, "time_of_addition": "Wed, Oct 07, 2020 12:10"}, "1212": {"seminar_date": "Fri, May 14, 2021", "seminar_time": "15:00", "timezone": "Europe/Vienna", "posted": "yes", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Ann Hermundstad", "speaker_affil": "HHMI Janelia", "speaker_twitter": "", "speaker_website": "https://www.janelia.org/lab/hermundstad-lab", "topic_tags": "", "seminar_title": "", "seminar_abstract": "", "hosted_by": "The Neurotheory Forum", "domain": ["Neuroscience"], "calendar_event_hash": "7e0ab619a40158c5cb9489e7bff154d41c6d1514b726346758faea8264f6a901", "seminar_id": 1212, "time_of_addition": "Wed, Oct 07, 2020 12:10"}, "1213": {"seminar_date": "Fri, May 21, 2021", "seminar_time": "15:00", "timezone": "Europe/Vienna", "posted": "yes", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Adrienne Fairhall", "speaker_affil": "University of Washington", "speaker_twitter": "@alfairhall", "speaker_website": "https://fairhalllab.com", "topic_tags": "", "seminar_title": "", "seminar_abstract": "", "hosted_by": "The Neurotheory Forum", "domain": ["Neuroscience"], "calendar_event_hash": "edf150bb296aa29a6c08daf5cece6953934be3dcdd6c8594eb5298b044b5f206", "seminar_id": 1213, "time_of_addition": "Wed, Oct 07, 2020 12:10"}, "1214": {"seminar_date": "Fri, Jun 4, 2021", "seminar_time": "15:00", "timezone": "Europe/Vienna", "posted": "yes", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Bianca Jones Marlin", "speaker_affil": "Columbia University", "speaker_twitter": "@bjmarlin", "speaker_website": "https://biancajonesmarlin.com/", "topic_tags": "", "seminar_title": "", "seminar_abstract": "", "hosted_by": "The Neurotheory Forum", "domain": ["Neuroscience"], "calendar_event_hash": "aed29f7074ebce46676f07e4a9d5da32ba7f3aefad753092a2335a060e7ec133", "seminar_id": 1214, "time_of_addition": "Wed, Oct 07, 2020 12:10"}, "862": {"seminar_date": "Fri, Sep 4, 2020", "seminar_time": "12:00", "timezone": "America/New_York", "posted": "Yes", "seminar_link": "https://www.crowdcast.io/e/huhx7zk9", "password": "", "video_on_demand": "https://youtu.be/a1rbx_m_7TE", "speaker_title": "Prof.", "seminar_speaker": "Tim Vogels", "speaker_affil": "IST Austria", "speaker_twitter": "@TPVogels", "speaker_website": "https://ist.ac.at/en/research/vogels-group/", "topic_tags": "theory", "seminar_title": "On the purpose and origin of spontaneous neural activity", "seminar_abstract": "Spontaneous firing, observed in many neurons, is often attributed to ion channel or network level noise. Cortical cells during slow wave sleep exhibit transitions between so called Up and Down states. In this sleep state, with limited sensory stimuli, neurons fire in the Up state. Spontaneous firing is also observed in slices of cholinergic interneurons, cerebellar Purkinje cells and even brainstem inspiratory neurons. In such in vitro preparations, where the functional relevance is long lost, neurons continue to display a rich repertoire of firing properties. It is perplexing that these neurons, instead of saving their energy during information downtime and functional irrelevance, are eager to fire. We propose that spontaneous firing is not a chance event but instead, a vital activity for the well-being of a neuron. We postulate that neurons, in anticipation of synaptic inputs, keep their ATP levels at maximum. As recovery from inputs requires most of the energy resources, neurons are ATP surplus and ADP scarce during synaptic quiescence. With ADP as the rate-limiting step, ATP production stalls in the mitochondria when ADP is low. This leads to toxic Reactive Oxygen Species (ROS) formation, which are known to disrupt many cellular processes. We hypothesize that spontaneous firing occurs at these conditions - as a release valve to spend energy and to restore ATP production, shielding the neuron against ROS. By linking a mitochondrial metabolism model to a conductance-based neuron model, we show that spontaneous firing depends on baseline ATP usage and on ATP-cost-per-spike. From our model, emerges a mitochondrial mediated homeostatic mechanism that provides a recipe for different firing patterns. Our findings, though mostly affecting intracellular dynamics, may have large knock-on effects on the nature of neural coding. Hitherto it has been thought that the neural code is optimised for energy minimisation, but this may be true only when neurons do not experience synaptic quiescence.", "hosted_by": "NYU Swartz", "domain": ["Neuroscience"], "calendar_event_hash": "c9485dafa2d85aa859cb428f2570e6aba154aa07370dc6632c48b074f3aa6274", "seminar_id": 862, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "375": {"seminar_date": "Fri, Sep 25, 2020", "seminar_time": "12:00", "timezone": "America/New_York", "posted": "YES", "seminar_link": "https://www.crowdcast.io/e/qybj7tz8", "password": "", "video_on_demand": "https://youtu.be/G3y-osyLTwk", "speaker_title": "Prof.", "seminar_speaker": "Rishidev Chaudhuri", "speaker_affil": "University of California, Davis", "speaker_twitter": "", "speaker_website": "https://chaudhurilab.ucdavis.edu/", "topic_tags": "theory", "seminar_title": "Using noise to probe recurrent neural network structure and prune synapses", "seminar_abstract": "Many networks in the brain are sparsely connected, and the brain eliminates synapses during development and learning. How could the brain decide which synapses to prune? In a recurrent network, determining the importance of a synapse between two neurons is a difficult computational problem, depending on the role that both neurons play and on all possible pathways of information flow between them. Noise is ubiquitous in neural systems, and often considered an irritant to be overcome. In the first part of this talk, I will suggest that noise could play a functional role in synaptic pruning, allowing the brain to probe network structure and determine which synapses are redundant. I will introduce a simple, local, unsupervised plasticity rule that either strengthens or prunes synapses using only synaptic weight and the noise-driven covariance of the neighboring neurons. For a subset of linear and rectified-linear networks, this rule provably preserves the spectrum of the original matrix and hence preserves network dynamics even when the fraction of pruned synapses asymptotically approaches 1. The plasticity rule is biologically-plausible and may suggest a new role for noise in neural computation. Time permitting, I will then turn to the problem of extracting structure from neural population data sets using dimensionality reduction methods. I will argue that nonlinear structures naturally arise in neural data and show how these nonlinearities cause linear methods of dimensionality reduction, such as Principal Components Analysis, to fail dramatically in identifying low-dimensional structure.", "hosted_by": "NYU Swartz", "domain": ["Neuroscience"], "calendar_event_hash": "9977c53ecb75a4031ac968ef832733420140ea9ceecd9fdbd9828fa54011d583", "seminar_id": 375, "time_of_addition": "Sat, Jul 18, 2020 00:17"}, "863": {"seminar_date": "Fri, Oct 16, 2020", "seminar_time": "12:00", "timezone": "America/New_York", "posted": "YES", "seminar_link": "https://www.crowdcast.io/e/stefano-fusi", "password": "", "video_on_demand": "", "speaker_title": "Prof.", "seminar_speaker": "Stefano Fusi", "speaker_affil": "Columbia University", "speaker_twitter": "@StefanoFusi2", "speaker_website": "https://ctn.zuckermaninstitute.columbia.edu/people/stefano-fusi", "topic_tags": "theory", "seminar_title": "The geometry of abstraction in hippocampus and pre-frontal cortex", "seminar_abstract": "The curse of dimensionality plagues models of reinforcement learning and decision-making. The process of abstraction solves this by constructing abstract variables describing features shared by different specific instances, reducing dimensionality and enabling generalization in novel situations. Here we characterized neural representations in monkeys performing a task where a hidden variable described the temporal statistics of stimulus-response-outcome mappings. Abstraction was defined operationally using the generalization performance of neural decoders across task conditions not used for training. This type of generalization requires a particular geometric format of neural representations. Neural ensembles in dorsolateral pre-frontal cortex, anterior cingulate cortex and hippocampus, and in simulated neural networks, simultaneously represented multiple hidden and explicit variables in a format reflecting abstraction. Task events engaging cognitive operations modulated this format. These findings elucidate how the brain and artificial systems represent abstract variables, variables critical for generalization that in turn confers cognitive flexibility.", "hosted_by": "NYU Swartz", "domain": ["Neuroscience"], "calendar_event_hash": "1b9777ad86f4f3251181e62316c43de8d639663e6099328ce0244e78e7356f77", "seminar_id": 863, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "864": {"seminar_date": "Fri, Nov 13, 2020", "seminar_time": "12:00", "timezone": "America/New_York", "posted": "YES", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "Prof.", "seminar_speaker": "Huizhong Tao", "speaker_affil": "University of Southern Calfornia", "speaker_twitter": "", "speaker_website": "https://keck.usc.edu/faculty-search/huizhong-tao/", "topic_tags": "", "seminar_title": "", "seminar_abstract": "", "hosted_by": "NYU Swartz", "domain": ["Neuroscience"], "calendar_event_hash": "8df5ed6e92fb1dd614bcf359930c4ff59ae29daff40dd80b5d366c42d3062f8e", "seminar_id": 864, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "865": {"seminar_date": "Fri, Dec 4, 2020", "seminar_time": "12:00", "timezone": "America/New_York", "posted": "YES", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "Prof.", "seminar_speaker": "Suzana Herculano-Houzel", "speaker_affil": "Vanderbilt University", "speaker_twitter": "@suzanahh", "speaker_website": "https://www.vanderbilt.edu/psychological_sciences/bio/suzana-herculano", "topic_tags": "", "seminar_title": "", "seminar_abstract": "", "hosted_by": "NYU Swartz", "domain": ["Neuroscience"], "calendar_event_hash": "15da4ddf0c27ad1d14140f3c83cd336d287b1f2cc6974690d7d80e50da33f80f", "seminar_id": 865, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "376": {"seminar_date": "Fri, Jan 8, 2021", "seminar_time": "12:00", "timezone": "America/New_York", "posted": "YES", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "Dr.", "seminar_speaker": "Carsen Stringer", "speaker_affil": "Janelia", "speaker_twitter": "@computingnature", "speaker_website": "https://www.janelia.org/lab/stringer-lab", "topic_tags": "", "seminar_title": "", "seminar_abstract": "", "hosted_by": "NYU Swartz", "domain": ["Neuroscience"], "calendar_event_hash": "b7d628d1bcb0faeca536b672f75b2a4aa9b3f65b92f271d76dc5776ed1915923", "seminar_id": 376, "time_of_addition": "Sat, Jul 18, 2020 00:17"}, "405": {"seminar_date": "Fri, Jan 22, 2021", "seminar_time": "12:00", "timezone": "America/New_York", "posted": "YES", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "Prof.", "seminar_speaker": "Luca Mazzucato", "speaker_affil": "University of Oregon", "speaker_twitter": "", "speaker_website": "https://www.mazzulab.com/", "topic_tags": "", "seminar_title": "", "seminar_abstract": "", "hosted_by": "NYU Swartz", "domain": ["Neuroscience"], "calendar_event_hash": "63744073e8ba66858e87f1f6802450deb476f04134dcc55e1e67311035918fb2", "seminar_id": 405, "time_of_addition": "Mon, Jul 27, 2020 02:40"}, "406": {"seminar_date": "Fri, Feb 19, 2021", "seminar_time": "12:00", "timezone": "America/New_York", "posted": "YES", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "Prof.", "seminar_speaker": "Christopher Harvey", "speaker_affil": "Harvard University", "speaker_twitter": "", "speaker_website": "http://harveylab.hms.harvard.edu/", "topic_tags": "", "seminar_title": "", "seminar_abstract": "", "hosted_by": "NYU Swartz", "domain": ["Neuroscience"], "calendar_event_hash": "5655dee2c9be775c060c7804bface39f6cafee7b4ddaa401bd314cd4ad29bf13", "seminar_id": 406, "time_of_addition": "Mon, Jul 27, 2020 02:40"}, "407": {"seminar_date": "Fri, Mar 12, 2021", "seminar_time": "12:00", "timezone": "America/New_York", "posted": "YES", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "Prof.", "seminar_speaker": "Kanaka Rajan", "speaker_affil": "Mount Sinai", "speaker_twitter": "@rajankdr", "speaker_website": "http://labs.neuroscience.mssm.edu/project/rajan-lab/", "topic_tags": "", "seminar_title": "", "seminar_abstract": "", "hosted_by": "NYU Swartz", "domain": ["Neuroscience"], "calendar_event_hash": "9e43f9ca03b8d93b7f74f0ba4becad49e12bd73164d03d7beaea58c2af6467e2", "seminar_id": 407, "time_of_addition": "Mon, Jul 27, 2020 02:40"}, "408": {"seminar_date": "Fri, Mar 26, 2021", "seminar_time": "12:00", "timezone": "America/New_York", "posted": "YES", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "Prof.", "seminar_speaker": "Tirin Moore", "speaker_affil": "Stanford University", "speaker_twitter": "", "speaker_website": "https://profiles.stanford.edu/tirin-moore", "topic_tags": "", "seminar_title": "", "seminar_abstract": "", "hosted_by": "NYU Swartz", "domain": ["Neuroscience"], "calendar_event_hash": "f10f4713dd3c9bbb6f21286c31f3a886bf8ece396bc166153efccd46d565ad51", "seminar_id": 408, "time_of_addition": "Mon, Jul 27, 2020 02:40"}, "409": {"seminar_date": "Fri, Apr 9, 2021", "seminar_time": "12:00", "timezone": "America/New_York", "posted": "YES", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "Dr.", "seminar_speaker": "Jessica Hamrick", "speaker_affil": "Deepmind", "speaker_twitter": "@jhamrick", "speaker_website": "http://www.jesshamrick.com/", "topic_tags": "", "seminar_title": "", "seminar_abstract": "", "hosted_by": "NYU Swartz", "domain": ["Neuroscience"], "calendar_event_hash": "5a4bd32ea430eb50a55777f3bc54d3987ce706895a65279f4bee3da66e933d49", "seminar_id": 409, "time_of_addition": "Mon, Jul 27, 2020 02:40"}, "410": {"seminar_date": "Fri, May 7, 2021", "seminar_time": "12:00", "timezone": "America/New_York", "posted": "YES", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "Prof.", "seminar_speaker": "Sara Solla", "speaker_affil": "Northwestern University", "speaker_twitter": "@SaraASolla", "speaker_website": "https://www.physio.northwestern.edu/faculty/profile.html?xid=16584", "topic_tags": "", "seminar_title": "", "seminar_abstract": "", "hosted_by": "NYU Swartz", "domain": ["Neuroscience"], "calendar_event_hash": "7068614bdad9ea47298a6224d6026fd83f9e8e8665fed2d2f2c1b26d84331b05", "seminar_id": 410, "time_of_addition": "Mon, Jul 27, 2020 02:40"}, "902": {"seminar_date": "Tue, Jun 16, 2020", "seminar_time": "17:00", "timezone": "Europe/Vienna", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/laura-cancedda", "password": "", "video_on_demand": "", "speaker_title": "Dr.", "seminar_speaker": "Laura Cancedda", "speaker_affil": "Istituto Italiano di Tecnologia (IIT)", "speaker_twitter": "", "speaker_website": "https://www.iit.it/people/laura-cancedda", "topic_tags": "development, neurodevelopmental disorders", "seminar_title": "Treating neurodevelopmental disorders: challenges, issues, problems, concerns, difficulties, harms, worries, doubts, but we need to start from somewhere", "seminar_abstract": "Neurodevelopmental disorders are a group of very heterogeneous diseases in which the development of the central nervous system is defective. In neurodevelopmental disorders defective brain development translates into aberrant brain function, which can manifest for example as impaired learning, motor function, or social interaction. Despites years of investigation in animal models and clinical research on neurodevelopmental disorders, there are currently no approved pharmacological treatments for core symptoms of the vast majority of them. Here, I will share some recent work (but also some apprehensions) of our laboratory on the development of strategies for the treatment of neurodevelopmental disorders, with a focus on Down syndrome.", "hosted_by": "NeuroDev Disorders", "domain": ["Neuroscience"], "calendar_event_hash": "22806c6c7988248ed362ec188cf51125743f352746922205638cf56120e173ce", "seminar_id": 902, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "903": {"seminar_date": "Tue, Jun 23, 2020", "seminar_time": "17:00", "timezone": "Europe/Vienna", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/carlos-portera-cailliau", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Carlos Portera-Cailliau", "speaker_affil": "UCLA", "speaker_twitter": "", "speaker_website": "https://porteralab.dgsom.ucla.edu/pages/", "topic_tags": "inhibition, sensory processing, autism", "seminar_title": "Circuit dysfunction and sensory processing in Fragile X Syndrome", "seminar_abstract": "To uncover the circuit-level alterations that underlie atypical sensory processing associated with autism, we have adopted a symptom-to-circuit approach in theFmr1-/- mouse model of Fragile X syndrome (FXS). Using a go/no-go task and in vivo 2-photon calcium imaging, we find that impaired visual discrimination in Fmr1-/- mice correlates with marked deficits in orientation tuning of principal neurons in primary visual cortex, and a decrease in the activity of parvalbumin (PV) interneurons. Restoring visually evoked activity in PV cells in Fmr1-/- mice with a chemogenetic (DREADD) strategy was sufficient to rescue their behavioural performance. Strikingly, human subjects with FXS exhibit similar impairments in visual discrimination as Fmr1-/- mice. These results suggest that manipulating inhibition may help sensory processing in FXS. More recently, we find that the ability of Fmr1-/- mice to perform the visual discrimination task is also drastically impaired in the presence of visual or auditory distractors, suggesting that sensory hypersensitivity may affect perceptual learning in autism.", "hosted_by": "NeuroDev Disorders", "domain": ["Neuroscience"], "calendar_event_hash": "ee60194797822742ba2763203f3ed2825a47fc287b7d424c028af1dda0c8f5e5", "seminar_id": 903, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "904": {"seminar_date": "Tue, Jun 30, 2020", "seminar_time": "17:00", "timezone": "Europe/Vienna", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/silvia-derubeis", "password": "", "video_on_demand": "", "speaker_title": "Ass. Prof", "seminar_speaker": "Silvia De Rubeis", "speaker_affil": "", "speaker_twitter": "", "speaker_website": "https://labs.icahn.mssm.edu/derubeislab/", "topic_tags": "autism, genetics", "seminar_title": "Autism spectrum disorder: from gene discovery to functional insights", "seminar_abstract": "Autism spectrum disorder (ASD) is a neurodevelopmental disorder affecting up to 1% of the population. Over the past few years, large-scale genomic studies have identified hundreds of genetic loci associated with liability to ASD. It is now time to translate these genetic discoveries into functional studies that can help us understand convergences and divergences across risk genes, and build pre-clinical cell and animal models. In this seminar, I will discuss some of the most recent findings on the genetic risk architecture of ASD. I will then expand on our work on biomarkers discovery and neurodevelopmental analyses in two rare genetic conditions associated with ASD: ADNP and DDX3X syndrome.", "hosted_by": "NeuroDev Disorders", "domain": ["Neuroscience"], "calendar_event_hash": "c247ae5ca0b4b836b00136f247704408f65ca24d39974c1a56270b6f59142dff", "seminar_id": 904, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "905": {"seminar_date": "Tue, Jul 7, 2020", "seminar_time": "17:00", "timezone": "Europe/Vienna", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/ukpong-b--eyo", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Ukpong B. Eyo", "speaker_affil": "University of Virginia", "speaker_twitter": "", "speaker_website": "https://med.virginia.edu/neuroscience/research/research/eyo-lab/", "topic_tags": "microglia, neurodevelopment", "seminar_title": "Microglial dynamics in neurodevelopment and pathology", "seminar_abstract": "In this talk, Dr. Eyo will his present research on microglia, the brain\u2019s resident immune cell. After providing some background to these cells, Dr. Eyo will highlight two aspects of his research. First, some of his previous work elucidating microglial dynamic activity during development as well as mechanisms regulating their demise during simulated developmental ischemia will be discussed. Second, research will be presented clarifying mechanisms underlying the interactions between microglia and neurons with a special focus on seizure disorders. Together, these findings highlight microglia as a critical cell type in brain function in development and brain pathology", "hosted_by": "NeuroDev Disorders", "domain": ["Neuroscience"], "calendar_event_hash": "22f4859f39c78dc9647090939c3b9ca7939a9fb224bccd79cf6560ab89408785", "seminar_id": 905, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "906": {"seminar_date": "Tue, Jul 14, 2020", "seminar_time": "17:00", "timezone": "Europe/Vienna", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/jean-bernard-manent", "password": "", "video_on_demand": "", "speaker_title": "Dr.", "seminar_speaker": "Jean-Bernard Manent", "speaker_affil": "", "speaker_twitter": "", "speaker_website": "", "topic_tags": "development", "seminar_title": "Misplaced and misconnected: circuit-level defects in malformations of cortical development", "seminar_abstract": "During histogenesis of the cerebral cortex, a proper laminar placement of defined numbers of specific cellular types is necessary to ensure proper functional connectivity patterns. There is a wide range of cortical malformations causing epilepsy and intellectual disability in humans, characterized with various degrees of neuronal misplacement, aberrant circuit organization or abnormal folding patterns. Although progress in human neurogenetics and brain imaging techniques have considerably advanced the identification of their causative genes, the pathophysiological mechanisms associated with defective cerebral cortex development remain poorly understood. In my presentation, I will outline some of our recent works in rodent models illustrating how misplaced neurons forming grey matter heterotopia, a cortical malformation subtype, interfere with the proper development of cortical circuits, and induce both local and distant circuitry changes associated with the subsequent emergence of epilepsy.", "hosted_by": "NeuroDev Disorders", "domain": ["Neuroscience"], "calendar_event_hash": "c2c405a3ea01621c6a6bb13316f7c997c4ef7b6950cc894da731859a1e62a5fb", "seminar_id": 906, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "907": {"seminar_date": "Tue, Jul 21, 2020", "seminar_time": "17:00", "timezone": "Europe/Vienna", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/gina-turrigiano-2", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Gina Turrigiano", "speaker_affil": "Brandeis University", "speaker_twitter": "", "speaker_website": "https://www.brandeis.edu/biology/faculty/turrigiano-gina.html", "topic_tags": "disease, plasticity", "seminar_title": "Autism-Associated Shank3 Is Essential for Homeostatic Compensation in Rodent Visual Cortex", "seminar_abstract": "Neocortical networks must generate and maintain stable activity patterns despite perturbations induced by learning and experience- dependent plasticity. There is abundant theoretical and experimental evidence that network stability is achieved through homeostatic plasticity mechanisms that adjust synaptic and neuronal properties to stabilize some measure of average activity, and this process has been extensively studied in primary visual cortex (V1), where chronic visual deprivation induces an initial drop in activity and ensemble average firing rates (FRs), but over time activity is restored to baseline despite continued deprivation. Here I discuss recent work from the lab in which we followed this FR homeostasis in individual V1 neurons in freely behaving animals during a prolonged visual deprivation/eye-reopening paradigm. We find that - when FRs are perturbed by manipulating sensory experience - over time they return precisely to a cell-autonomous set-point. Finally, we find that homeostatic plasticity is perturbed in a mouse model of Autism spectrum disorder, and this results in a breakdown of FRH within V1. These data suggest that loss of homeostatic plasticity is one primary cause of excitation/inhibition imbalances in ASD models. Together these studies illuminate the role of stabilizing plasticity mechanisms in the ability of neocortical circuits to recover robust function following challenges to their excitability.", "hosted_by": "NeuroDev Disorders", "domain": ["Neuroscience"], "calendar_event_hash": "555a2f58c47743d96bd238c8931075917d1653c37fa2dbbf6733729c2202b41b", "seminar_id": 907, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "908": {"seminar_date": "Tue, Sep 1, 2020", "seminar_time": "17:00", "timezone": "Europe/Vienna", "posted": "Yes", "seminar_link": "https://www.crowdcast.io/e/kevin-bender", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Kevin Bender", "speaker_affil": "UCSF", "speaker_twitter": "", "speaker_website": "https://www.cin.ucsf.edu/HTML/Kevin_Bender.html", "topic_tags": "neuromodulation", "seminar_title": "Sodium channel dysfunction in neurodevelopmental disorders", "seminar_abstract": "", "hosted_by": "NeuroDev Disorders", "domain": 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In this talk, I will discuss my lab\u2019s findings on how the human brain supports spatial memory and navigation based on our experiments with direct brain recordings from neurosurgical patients performing virtual-reality spatial memory tasks. I will show that humans have a network of neurons that represent where we are located and trying to go. This network includes some cell types that are similar to those seen in animals, such as place and grid cells, as well as others that have not been seen before in animals, such as anchor and spatial-target cells. I also will explore the role of network oscillations in human memory, where humans again show several distinctive patterns compared to animals. Whereas rodents generally show a hippocampal oscillation at ~8Hz, humans have two separate hippocampal oscillations, at low and high frequencies, which support memory and navigation, respectively. Finally, I will show that neural oscillations in humans are traveling waves, propagating across the cortex, to coordinate the timing of neuronal activity across regions, which is another property not seen in animals. A theme from this work is that in terms of navigation and memory the human brain has novel characteristics compared with animals, which helps explain our rich behavioural abilities and has implications for treating disease and neurological disorders.", "hosted_by": "BCCN Berlin", "domain": ["Neuroscience"], "calendar_event_hash": "82c7aaf6e567c636f878c29cf9db459c0bf3c892676d51cb61e6f81618402e7d", "seminar_id": 804, "time_of_addition": "Mon, Sep 28, 2020 11:06"}, "337": {"seminar_date": "Wed, July 8, 2020", "seminar_time": "16:00", "timezone": "Europe/Berlin", "posted": "yes", "seminar_link": "https://hu-berlin.zoom.us/j/92652527827", "password": "", "video_on_demand": "", "speaker_title": "Prof.", "seminar_speaker": "Martin Giese", "speaker_affil": "University of T\u00fcbingen", "speaker_twitter": "@Compens", "speaker_website": "http://www.compsens.uni-tuebingen.de/compsens/index.php/publications/patents?publications_view_all=1&theses_view_all=0&projects_view_all=0&task=show&view=member&id=1", "topic_tags": "sensorimotor control, high level vision", "seminar_title": "Neural and computational principles of the processing of dynamic faces and bodies", "seminar_abstract": "Body motion is a fundamental signal of social communication. This includes facial as well as full-body movements. Combining advanced methods from computer animation with motion capture in humans and monkeys, we synthesized highly-realistic monkey avatar models. Our face avatar is perceived by monkeys as almost equivalent to a real animal, and does not induce an \u2018uncanny valley effect\u2019, unlike all other previously used avatar models in studies with monkeys. Applying machine-learning methods for the control of motion style, we were able to investigate how species-specific shape and dynamic cues influence the perception of human and monkey facial expressions. Human observers showed very fast learning of monkey expressions, and a perceptual encoding of expression dynamics that was largely independent of facial shape. This result is in line with the fact that facial shape evolved faster than the neuromuscular control in primate phylogenesis. At the same time, it challenges popular neural network models of the recognition of dynamic faces that assume a joint encoding of facial shape and dynamics. We propose an alternative physiologically-inspired neural model that realizes such an orthogonal encoding of facial shape and expression from video sequences.\n\nAs second example, we investigated the perception of social interactions from abstract stimuli, similar to the ones by Heider & Simmel (1944), and also from more realistic stimuli. We developed and validated a new generative model for the synthesis of such social interaction, which is based on a modification of human navigation model. We demonstrate that the recognition of such stimuli, including the perception of agency, can be accounted for by a relatively elementary physiologically-inspired hierarchical neural recognition model, that does not require the assumption of sophisticated inference mechanisms, as postulated by some cognitive theories of social recognition.\n\nSummarizing, this suggests that essential phenomena in social cognition might be accounted for by a small set of simple neural principles that can be easily implemented by cortical circuits. The developed technologies for stimulus control form the basis of electrophysiological studies that can verify specific neural circuits, as the ones proposed by our theoretical models.", "hosted_by": "BCCN Berlin", "domain": ["Neuroscience"], "calendar_event_hash": "3d82935e37fff9c1d8df81f66a36205ca73ec2382e1405c6340527093290810a", "seminar_id": 337, "time_of_addition": "Mon, Jul 06, 2020 15:18"}, "355": {"seminar_date": "Wed, July 15, 2020", "seminar_time": "16:00", "timezone": "Europe/Berlin", "posted": "yes", "seminar_link": "https://tu-berlin.zoom.us/j/92147414281?pwd=UFBjQ0ZGUWJTMDh0dlB0MkRwazhSUT09", "password": "", "video_on_demand": "", "speaker_title": "PhD", "seminar_speaker": "Terry Stewart", "speaker_affil": "University of Waterloo and National Research Center Canada", "speaker_twitter": "", "speaker_website": "http://compneuro.uwaterloo.ca/people/terrence-c-stewart.html", "topic_tags": "nengo", "seminar_title": "Using Nengo and the Neural Engineering Framework to Represent Time and Space", "seminar_abstract": "The Neural Engineering Framework (and the associated software tool Nengo) provide a general method for converting algorithms into neural networks with an adjustable level of biological plausibility. I will give an introduction to this approach, and then focus on recent developments that have shown new insights into how brains represent time and space. This will start with the underlying mathematical formulation of ideal methods for representing continuous time and continuous space, then show how implementing these in neural networks can improve Machine Learning tasks, and finally show how the resulting systems compare to temporal and spatial representations in biological brains.", "hosted_by": "BCCN Berlin", "domain": ["Neuroscience"], "calendar_event_hash": "bb06e991d4dd69ff192a1518daa7b46d8f93ade86aa000d65fe64175d8ea5c03", "seminar_id": 355, "time_of_addition": "Mon, Jul 13, 2020 11:50"}, "945": {"seminar_date": "Wed, October 14, 2020", "seminar_time": "16:00", "timezone": "Europe/Berlin", "posted": "yes", "seminar_link": "https://hu-berlin.zoom.us/j/64995583573?pwd=TUl2eVorNWgra2tjQTBLUVFva2lWUT09", "password": "", "video_on_demand": "", "speaker_title": "Prof.", "seminar_speaker": "Gaute Einevoll", "speaker_affil": "Norwegian University of Life Sciences", "speaker_twitter": "https://twitter.com/gauteeinevoll", "speaker_website": "http://www.nmbu.no/ans/gaute.einevoll", "topic_tags": "", "seminar_title": "", "seminar_abstract": "Starting with the work of Hodgkin and Huxley in the 1950s, we now have a fairly good understanding of how the spiking activity of neurons can be modelled mathematically. For cortical circuits the understanding is much more limited. Most network studies have considered stylized models with a single or a handful of neuronal populations consisting of identical neurons with statistically identical connection properties. However, real cortical networks have heterogeneous neural populations and much more structured synaptic connections. Unlike typical simplified cortical network models, real networks are also \u201cmultipurpose\u201d in that they perform multiple functions.  \n  \nHistorically the lack of computational resources has hampered the mathematical exploration of cortical networks.  With the advent of modern supercomputers, however, simulations of networks comprising hundreds of thousands biologically detailed neurons are becoming feasible (Einevoll et al, Neuron, 2019). Further, a large-scale biologically network model of the mouse primary visual cortex comprising 230.000 neurons has recently been developed at the Allen Institute for Brain Science (Billeh et al, Neuron, 2020). Using this model as a starting point, I will discuss how we can move towards multipurpose models that incorporate the true biological complexity of cortical circuits and faithfully reproduce multiple experimental observables such as spiking activity, local field potentials or two-photon calcium imaging signals. Further, I will discuss how such validated comprehensive network models can be used to gain insights into the functioning of cortical circuits.", "hosted_by": "BCCN Berlin", "domain": ["Neuroscience"], "calendar_event_hash": "73fdb91c8b55078891fa8afc0f2defc05d1e3b2581bae6245908b1a24ed6e39f", "seminar_id": 945, "time_of_addition": "Wed, Sep 30, 2020 00:20"}, "1132": {"seminar_date": "Wed, Oct 7, 2020", "seminar_time": "11:00", "timezone": "America/New_York", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/jgleeson", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Joseph Gleeson", "speaker_affil": "UC San Diego; Rady Children's Institute for Genomic Medicine", "speaker_twitter": "", "speaker_website": "http://www.gleesonlab.org", "topic_tags": "autism, genetics", "seminar_title": "De novo mutations in autism and contributions from sperm mosaicism", "seminar_abstract": "", "hosted_by": "Seaver Autism Center", "domain": ["Neuroscience"], "calendar_event_hash": "9ffe746157745e2d99474b917a71738987810d977ed77cfceed69bd9421a594c", "seminar_id": 1132, "time_of_addition": "Mon, Oct 05, 2020 13:10"}, "1133": {"seminar_date": "Wed, Oct 21, 2020", "seminar_time": "11:00", "timezone": "America/New_York", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/nael-nadif-kasri", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Nael Nadif Kasri", "speaker_affil": "Radboudumc (Nijmegen, The Netherlands)", "speaker_twitter": "@naelnadif", "speaker_website": "http://www.nadifkasri-lab.com/Home.html", "topic_tags": "autism, stem cells", "seminar_title": "Harnessing the potential of human neurons-on-a-chip to model neurodevelopmental disorders", "seminar_abstract": "", "hosted_by": "Seaver Autism Center", "domain": ["Neuroscience"], "calendar_event_hash": "7fb49e07a6056490a5a099b33b9d7599630bd03598c5f1d9e46214f5b14dc45e", "seminar_id": 1133, "time_of_addition": "Mon, Oct 05, 2020 13:10"}, "1134": {"seminar_date": "Wed, Nov 4, 2020", "seminar_time": "11:00", "timezone": "America/New_York", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/carlo-sala", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Carlo Sala", "speaker_affil": "CNR (Milan, Italy)", "speaker_twitter": "", "speaker_website": "http://www.in.cnr.it/index.php/it/9-people/58-carlo-sala", "topic_tags": "autism, synapses, mouse models", "seminar_title": "The role of protein translation pathways in regulating excitation/inhibition balance in epilepsy", "seminar_abstract": "", "hosted_by": "Seaver Autism Center", "domain": ["Neuroscience"], "calendar_event_hash": "55125d24d7a53b41428c847bd69767b324e7c77276c4d20f0024a7e6fc0ade04", "seminar_id": 1134, "time_of_addition": "Mon, Oct 05, 2020 13:10"}, "1135": {"seminar_date": "Wed, Nov 18, 2020", "seminar_time": "11:00", "timezone": "America/New_York", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/a-gozzi", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Alessandro Gozzi", "speaker_affil": "Istituto Italiano di Tecnologia (Rovereto, Italy)", "speaker_twitter": "@Gozzi_Ale", "speaker_website": "https://www.iit.it/index.php/people/alessandro-gozzi", "topic_tags": "autism, functional neuroimaging, mouse models", "seminar_title": "Unravelling brain connectopathy in autism with cross-species fMRI", "seminar_abstract": "", "hosted_by": "Seaver Autism Center", "domain": ["Neuroscience"], "calendar_event_hash": "97190948903b9d9749bcd1d0a3effd83b7d2e3d905ede4ef165b3f1b1910d984", "seminar_id": 1135, "time_of_addition": "Mon, Oct 05, 2020 13:10"}, "1136": {"seminar_date": "Wed, Dec 2, 2020", "seminar_time": "11:00", "timezone": "America/New_York", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/e-lim", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Elaine Lim", "speaker_affil": "Massachusetts Medical School", "speaker_twitter": "@elimtt", "speaker_website": "https://umassmed.edu/elimlab/", "topic_tags": "autism, organoids, computational methods", "seminar_title": "Multiplexing and Demultiplexing with cerebral organoids for neurological diseases", "seminar_abstract": "", "hosted_by": "Seaver Autism Center", "domain": ["Neuroscience"], "calendar_event_hash": "b9cf713fce494b453987a51c7beb4033d8dd71daf658078acfcea860f4b67493", "seminar_id": 1136, "time_of_addition": "Mon, Oct 05, 2020 13:10"}, "1137": {"seminar_date": "Wed, Dec 16, 2020", "seminar_time": "11:00", "timezone": "America/New_York", "posted": "yes", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Xinyu Zhao", "speaker_affil": "University of Wisconsin\u2013Madison", "speaker_twitter": "", "speaker_website": "http://zhaoneurosciencelab.wordpress.com", "topic_tags": "autism, stem cells", "seminar_title": "", "seminar_abstract": "", "hosted_by": "Seaver Autism Center", "domain": ["Neuroscience"], "calendar_event_hash": "0da042b2f4980ecd8d8523aa7604809869b0063c7001c584f251d9c0663bd141", "seminar_id": 1137, "time_of_addition": "Mon, Oct 05, 2020 13:10"}, "1138": {"seminar_date": "Wed, Jan 20, 2021", "seminar_time": "13:00", "timezone": "America/New_York", "posted": "yes", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Stephan Sanders", "speaker_affil": "UC San Francisco", "speaker_twitter": "", "speaker_website": "https://sanderslab.github.io", "topic_tags": "autism, genetics", "seminar_title": "", "seminar_abstract": "", "hosted_by": "Seaver Autism Center", "domain": ["Neuroscience"], "calendar_event_hash": "a03b78102ae4f7b68ee7ffc0aa06929f87da35a9eada2c79d20639c5336e5229", "seminar_id": 1138, "time_of_addition": "Mon, Oct 05, 2020 13:10"}, "1139": {"seminar_date": "Wed, Feb 3, 2021", "seminar_time": "11:00", "timezone": "America/New_York", "posted": "yes", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Ukpong Eyo", "speaker_affil": "The University of Virginia", "speaker_twitter": "@eyolab", "speaker_website": "https://med.virginia.edu/neuroscience/research/research/eyo-lab/", "topic_tags": "autism, microglia", "seminar_title": "", "seminar_abstract": "", "hosted_by": "Seaver Autism Center", "domain": ["Neuroscience"], "calendar_event_hash": "5cb2a63c3d78776265c2c832c95cfce99a509e893ce87da09f9460bb00cba15c", "seminar_id": 1139, "time_of_addition": "Mon, Oct 05, 2020 13:10"}, "1140": {"seminar_date": "Wed, Feb 17, 2021", "seminar_time": "11:00", "timezone": "America/New_York", "posted": "yes", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Maria Chahrour", "speaker_affil": "UT SouthWestern", "speaker_twitter": "@MariaChahrour", "speaker_website": "http://chahrourlab.org", "topic_tags": "autism, genetics", "seminar_title": "", "seminar_abstract": "", "hosted_by": "Seaver Autism Center", "domain": ["Neuroscience"], "calendar_event_hash": "4a25a3176972a77f4ca1b2e9e42b525f761a0f64565c5d0bcf0dad3075c56a84", "seminar_id": 1140, "time_of_addition": "Mon, Oct 05, 2020 13:10"}, "1141": {"seminar_date": "Wed, Mar 3, 2021", "seminar_time": "11:00", "timezone": "America/New_York", "posted": "yes", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Elise Robinson", "speaker_affil": "Broad Institute", "speaker_twitter": "@elisebrobinson", "speaker_website": "https://www.robinsonlab.org", "topic_tags": "autism, genetics", "seminar_title": "", "seminar_abstract": "", "hosted_by": "Seaver Autism Center", "domain": ["Neuroscience"], "calendar_event_hash": "c5ffa80d7d49c0e0621a1ab0d0759531fcb207c4e0a1435d3e392ad754622449", "seminar_id": 1141, "time_of_addition": "Mon, Oct 05, 2020 13:10"}, "665": {"seminar_date": "Thu, Jul 2, 2020", "seminar_time": "14:00", "timezone": "Europe/Lisbon", "posted": "yes", "seminar_link": "https://champalimaud-research.zoom.us/j/94301488120", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "David Schoppik", "speaker_affil": "New York University Grossman School of Medicine", "speaker_twitter": "@schoppik", "speaker_website": "http://www.schoppiklab.com/", "topic_tags": "zebrafish, brainstem, spinal cord", "seminar_title": "How the brain comes to balance: Development of postural stability and its neural architecture in larval zebrafish", "seminar_abstract": "Maintaining posture is a vital challenge for all freely-moving organisms. As animals grow, their relationship to destabilizing physical forces changes. How does the nervous system deal with this ongoing challenge? Vertebrates use highly conserved vestibular reflexes to stabilize the body. We established the larval zebrafish as a new model system to understand the development of the vestibular reflexes responsible for balance. In this talk, I will begin with the biophysical challenges facing baby fish as they learn to swim. I\u2019ll briefly review published work by David Ehrlich, Ph.D., establishing a fundamental relationship between postural stability and locomotion. The bulk of the talk will highlight unpublished work by Kyla Hamling. She discovered that a small (~50) population of molecularly-defined brainstem neurons called vestibulo-spinal cells act as a nexus for postural development. Her loss-of-function experiments show that these neurons contribute more to postural stability as animals grow older. I\u2019ll end with brief highlights from her ongoing work examining tilt-evoked responses of these neurons using 2-photon imaging and the consequences of downstream activity in the spinal cord using single-objective light-sheet (SCAPE) microscopy", "hosted_by": "Champalimaud Colloquia", "domain": ["Neuroscience"], "calendar_event_hash": "4f71e62e873f24cd82cf3501d85b8d979790ccb821833c3098e9ed0a9a9d796a", "seminar_id": 665, "time_of_addition": "Tue, Sep 15, 2020 14:46"}, "666": {"seminar_date": "Thu, Jul 9, 2020", "seminar_time": "14:00", "timezone": "Europe/Lisbon", "posted": "yes", "seminar_link": "https://champalimaud-research.zoom.us/webinar/register/WN_7krgaNHZQtWy0Hl_IsezSw", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Christiane Linster", "speaker_affil": "Cornell University", "speaker_twitter": "", "speaker_website": "https://nbb.cornell.edu/christiane-linster", "topic_tags": "neural coding, memory, olfactory system", "seminar_title": "Cholinergic regulation of learning in the olfactory system", "seminar_abstract": "In the olfactory system, cholinergic modulation has been associated with contrast modulation and changes in receptive fields in the olfactory bulb, as well the learning of odor associations in the olfactory cortex. Computational modeling and behavioral studies suggest that cholinergic modulation could improve sensory processing and learning while preventing pro-active interference when task demands are high. However, how sensory inputs and/or learning regulate incoming modulation has not yet been elucidated. We here use a computational model of the olfactory bulb, piriform cortex (PC) and horizontal limb of the diagonal band of Broca (HDB) to explore how olfactory learning could regulate cholinergic inputs to the system in a closed feedback loop. In our model, the novelty of an odor is reflected in firing rates and sparseness of cortical neurons in response to that odor and these firing rates can directly regulate learning in the system by modifying cholinergic inputs to the system.", "hosted_by": "Champalimaud Colloquia", "domain": ["Neuroscience"], "calendar_event_hash": "426f36355ca05a32be6fc133cfa6fd2ea6519e1b797f490d061a7231f2ff58af", "seminar_id": 666, "time_of_addition": "Tue, Sep 15, 2020 14:46"}, "667": {"seminar_date": "Thu, Jul 16, 2020", "seminar_time": "10:00", "timezone": "Europe/Lisbon", "posted": "yes", "seminar_link": "https://champalimaud-research.zoom.us/webinar/register/WN_TCauKh4vQ-qJ8YBu3z16_g", "password": "", "video_on_demand": "", "speaker_title": "Dr.", "seminar_speaker": "Kumi O. Kuroda", "speaker_affil": "RIKEN Center for Brain Science", "speaker_twitter": "", "speaker_website": "https://cbs.riken.jp/en/faculty/k.kuroda/", "topic_tags": "", "seminar_title": "", "seminar_abstract": "Mammalian neonates are born immature. Thus mothers are equipped with innate motivation to nurture them. Moreover, in species that live in a family group, fathers and older siblings may also provide extensive care to the young. By studying those highly social species, including laboratory mice, common marmosets, and humans, we are trying to elucidate the neural mechanisms of parental care. Neuronal activity mapping and site-specific functional suppression in mice identified the central part of the medial preoptic area (cMPOA) as the hub of caregiving network for both mothers and fathers.Recent findings about the neural circuit and molecular signaling involved in caregiving motivation will be discussed.", "hosted_by": "Champalimaud Colloquia", "domain": ["Neuroscience"], "calendar_event_hash": "d30563f40705f1478b214353be3452e653f30c1581965e28a186edd56e17a1c8", "seminar_id": 667, "time_of_addition": "Tue, Sep 15, 2020 14:46"}, "668": {"seminar_date": "Thu, Jul 23, 2020", "seminar_time": "14:00", "timezone": "Europe/Lisbon", "posted": "yes", "seminar_link": "https://champalimaud-research.zoom.us/webinar/register/WN_sBLYOz9dQsquZ1nyeLIz_Q", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Ansgar B\u00fcschges", "speaker_affil": "Department of Animal Physiology, Institute of Zoology, University of Cologne", "speaker_twitter": "@bueschges_lab", "speaker_website": "https://zoologie.uni-koeln.de/arbeitsgruppen/ag-bueschges", "topic_tags": "neural control, locomotion", "seminar_title": "The complexity of the ordinary \u2013 neural control of locomotion", "seminar_abstract": "Today, considerable information is available on the organization and operation of the neural networks that generate the motor output for animal locomotion, such as swimming, walking, or flying. In recent years, the question of which neural mechanisms are responsible for task-specific and flexible adaptations of locomotor patterns has gained increased attention in the field of motor control. I will report on advances we made with respect to this topic for walking in insects, i.e. the leg muscle control system of phasmids and fruit flies. I will present insights into the neural basis of speed control, heading, walking direction, and the role of ground contact in insect walking, both for local control and intersegmental coordination. For these changes in motor activity modifications in the processing of sensory feedback signals play a pivotal role, for instance for movement and load signals in heading and curve walking or for movement signals that contribute to intersegmental coordination. Our recent findings prompt future investigations that aim to elucidate the mechanisms by which descending and intersegmental signals interact with local networks in the generation of motor flexibility during walking in animals.", "hosted_by": "Champalimaud Colloquia", "domain": ["Neuroscience"], "calendar_event_hash": "ea2669eb60dde3358fd9635e0c5b7bf6c6887fb94b70880dcc4e28814022eb77", "seminar_id": 668, "time_of_addition": "Tue, Sep 15, 2020 14:46"}, "669": {"seminar_date": "Thu, Sep 17, 2020", "seminar_time": "14:00", "timezone": "Europe/Lisbon", "posted": "yes", "seminar_link": "https://champalimaud-research.zoom.us/webinar/register/WN_T0DaPFsISNa06_vXEmKCAA", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "David McCormick", "speaker_affil": "University of Oregon", "speaker_twitter": "@DavidAMcCormick", "speaker_website": "www.neurobiology.org", "topic_tags": "neural mechanisms, variations, brain, behaviour", "seminar_title": "Rapid State Changes Account for Apparent Brain and Behavior Variability", "seminar_abstract": "Neural and behavioral responses to sensory stimuli are notoriously variable from trial to trial.  Does this mean the brain is inherently noisy or that we don\u2019t completely understand the nature of the brain and behavior?  Here we monitor the state of activity of the animal through videography of the face, including pupil and whisker movements, as well as walking, while also monitoring the ability of the animal to perform a difficult auditory or visual task.  We find that the state of the animal is continuously changing and is never stable.  The animal is constantly becoming more or less activated (aroused) on a second and subsecond scale.  These changes in state are reflected in all of the neural systems we have measured, including cortical, thalamic, and neuromodulatory activity.  Rapid changes in cortical activity are highly correlated with changes in neural responses to sensory stimuli and the ability of the animal to perform auditory or visual detection tasks.  On the intracellular level, these changes in forebrain activity are associated with large changes in neuronal membrane potential and the nature of network activity (e.g. from slow rhythm generation to sustained activation and depolarization).  Monitoring cholinergic and noradrenergic axonal activity reveals widespread correlations across the cortex.  However, we suggest that a significant component of these rapid state changes arise from glutamatergic pathways (e.g. corticocortical or thalamocortical), owing to their rapidity.  Understanding the neural mechanisms of state-dependent variations in brain and behavior promises to significantly \u201cdenoise\u201d our understanding of the brain.", "hosted_by": "Champalimaud Colloquia", "domain": ["Neuroscience"], "calendar_event_hash": "d87fb0b4da97019d5f808ae1c2f65f548c21ec169c7dfd0f95684f0a1046d185", "seminar_id": 669, "time_of_addition": "Tue, Sep 15, 2020 14:46"}, "717": {"seminar_date": "Thu, Sep 24, 2020", "seminar_time": "12:00", "timezone": "Europe/Lisbon", "posted": "yes", "seminar_link": "https://champalimaud-research.zoom.us/webinar/register/WN_7NddzhJDQy2DQA9cASXwRw", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Catherine Dulac", "speaker_affil": "Harvard University", "speaker_twitter": "@DulacLab", "speaker_website": "https://www.dulaclab.com/", "topic_tags": "cell transcriptomics, social behaviour", "seminar_title": "Neurobiology of Social Behavior", "seminar_abstract": "Social interactions are central to the human experience, yet it is also one of the faculty of the brain that is the most impaired by mental illness. Similarly, social interactions are essential for animals to survive, reproduce, and raise their young. Over the years, my lab has attempted to decipher the unique characteristics of social recognition: what are the unique cues that trigger distinct social behaviors, what is the nature and identity of social behavior circuits, how is the function of these circuits different in males and females and how are they modulated by the animal physiological status? In this lecture, I will describe our recent progress in using genetic, imaging, molecular and behavioral approaches to understand how the brain controls specific social behaviors in both males and females, and how areas throughout the brain participate in the positive and negative controls of specific social interactions. I will also describe how new approaches of single cell transcriptomics have enabled us to uncover specific cell populations involved in distinct social behaviors and the basis of their activity modulation according to the animal state.", "hosted_by": "Champalimaud Colloquia", "domain": ["Neuroscience"], "calendar_event_hash": "06e8eb45ec68905af5dccd9d5ab4e5e2423603da9b6802e696037f47e386385c", "seminar_id": 717, "time_of_addition": "Mon, Sep 21, 2020 15:50"}, "719": {"seminar_date": "Thu, Oct 8, 2020", "seminar_time": "14:00", "timezone": "Europe/Lisbon", "posted": "yes", "seminar_link": "https://champalimaud-research.zoom.us/webinar/register/WN_fQgrlbYeSsCfplVvLW1miQ", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Benjamin de Bivort", "speaker_affil": "Harvard University", "speaker_twitter": "@debivort", "speaker_website": "http://lab.debivort.org/", "topic_tags": "drosophila, olfactory circuit, behaviour", "seminar_title": "Functional and structural loci of individuality in the Drosophila olfactory circuit", "seminar_abstract": "Behavior varies even among genetically identical animals raised in the same environment. However, little is known about the circuit or anatomical underpinnings of this individuality, though previous work implicates sensory periphery. Drosophila olfaction presents an ideal model to study the biological basis of behavioral individuality, because while the neural circuit underlying olfactory behavior is well-described and highly stereotyped, persistent idiosyncrasy in behavior, neural coding, and neural wiring have also been described. Projection neurons (PNs), which relay odor signals sensed by olfactory receptor neurons (ORNs) to deeper brain structures, exhibit variable calcium responses to identical odor stimuli across individuals, but how these idiosyncrasies relate to individual behavioral responses remains unknown. Here, using paired behavior and two-photon imaging measurements, we show that idiosyncratic calcium dynamics in both ORNs and PNs predict individual preferences for an aversive monomolecular odorant versus air, suggesting that variation at the periphery of the olfactory system determines individual preference for an odor\u2019s presence. In contrast, PN, but not ORN, calcium responses predict individual preferences in a two-odor choice assay. Furthermore, paired behavior and immunohistochemistry measurements reveal that variation in ORN presynaptic density also predicts two-odor preference, suggesting this site is a locus of individuality where microscale circuit variation gives rise to idiosyncrasy in behavior. Our results demonstrate how a neural circuit may vary functionally and structurally to produce variable behavior among individuals.", "hosted_by": "Champalimaud Colloquia", "domain": ["Neuroscience"], "calendar_event_hash": "defa2780a696870574fea047b7584de1512cf2ab9b92f14812d8d5a0bcd81126", "seminar_id": 719, "time_of_addition": "Mon, Sep 21, 2020 17:15"}, "1061": {"seminar_date": "Thu, Oct 15, 2020", "seminar_time": "12:00", "timezone": "Europe/Lisbon", "posted": "yes", "seminar_link": "https://champalimaud-research.zoom.us/webinar/register/WN_UTOcDGAZSDmNzoaDHBW9qA", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Daniel Wolpert", "speaker_affil": "Columbia University", "speaker_twitter": "@DMWolpert", "speaker_website": "https://wolpertlab.neuroscience.columbia.edu/", "topic_tags": "motor learning, contextual inference", "seminar_title": "Contextual inference underlies the learning of sensorimotor repertoires", "seminar_abstract": "Humans spend a lifetime learning, storing and refining a repertoire of motor memories. However, it is unknown what principle underlies the way our continuous stream of sensori-motor experience is segmented into separate memories and how we adapt and use this growing repertoire. Here we develop a principled theory of motor learning based on the key insight that memory creation, updating, and expression are all controlled by a single computation \u2013 contextual inference. Unlike dominant theories of single-context learning, our repertoire-learning model accounts for key features of motor learning that had no unified explanation and predicts novel phenomena, which we confirm experimentally. These results suggest that contextual inference is the key principle underlying how a diverse set of experiences is reflected in motor behavior.", "hosted_by": "Champalimaud Colloquia", "domain": ["Neuroscience"], "calendar_event_hash": "f85a0503879a6e930551dba7665426524be84f1df042cef4bd48ba8b00ca2e3b", "seminar_id": 1061, "time_of_addition": "Fri, Oct 02, 2020 00:24"}, "690": {"seminar_date": "Thu, Oct 22, 2020", "seminar_time": "15:30", "timezone": "Europe/Lisbon", "posted": "yes", "seminar_link": "https://champalimaud-research.zoom.us/webinar/register/WN_zH0pGog3T-mxiP2KyNaC_w", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Lisa Giocomo", "speaker_affil": "Stanford University", "speaker_twitter": "@lisa_giocomo", "speaker_website": "https://giocomolab.weebly.com/", "topic_tags": "neural maps, behaviour", "seminar_title": "Multiple maps for navigation", "seminar_abstract": "Over the last several decades, the tractable response properties of parahippocampal neurons have provided a new access key to understanding the cognitive process of self-localization: the ability to know where you are currently located in space. Defined by functionally discrete response properties, neurons in the medial entorhinal cortex and hippocampus are proposed to provide the basis for an internal neural map of space, which enables animals to perform path-integration based spatial navigation and supports the formation of spatial memories. My lab focuses on understanding the mechanisms that generate this neural map of space and how this map is used to support behavior. In this talk, I\u2019ll discuss how learning and experience shapes our internal neural maps of space to guide behavior.", "hosted_by": "Champalimaud Colloquia", "domain": ["Neuroscience"], "calendar_event_hash": "b4e1c3e4f468b2d9049230eba6521e5875c81fdaed59a6d766959acf513e49d4", "seminar_id": 690, "time_of_addition": "Fri, Sep 18, 2020 16:00"}, "1215": {"seminar_date": "Thu, Oct 29, 2020", "seminar_time": "12:00", "timezone": "Europe/Lisbon", "posted": "yes", "seminar_link": "https://champalimaud-research.zoom.us/webinar/register/WN_AhIQaBYYSz-6ftc_U1o3Sg", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Jens Br\u00fcning", "speaker_affil": "Max Planck Institute for Metabolism Research", "speaker_twitter": "", "speaker_website": "https://www.sf.mpg.de/research/bruening", "topic_tags": "integrative physiology, obesity, neurocircuits, maternal metabolism", "seminar_title": "Neurocircuits in control of integrative physiology", "seminar_abstract": "This open colloquia will be part of a special workshop dedicated to obesity. Proopiomelanocortin (POMC)- and agouti related peptide (AgRP)-expressing neurons in the arcuate nucleus of the hypothalamus (ARH) are critical regulators of food intake and energy homeostasis. They rapidly integrate the energy state of the organism through sensing fuel availability via hormones, nutrient components and even rapidly upon sensory food perception. Importantly, they not only regulate feeding responses, but numerous autonomic responses including glucose and lipid metabolism, inflammation and blood pressure. More recently, we could demonstrate that sensory food cue-dependent regulation of POMC neurons primes the hepatic endoplasmic reticulum (ER) stress response to prime liver metabolism for the postpramndial state. The presentation will focus on the regulation of these neurons in control of integrative physiology, the identification of distinct neuronal circuitries targeted by these cells and finally on the broad range implications resulting from dysregulation of these circuits as a consequence of altered maternal metabolism.", "hosted_by": "Champalimaud Colloquia", "domain": ["Neuroscience"], "calendar_event_hash": "23e13d7b6a375d47588670777d571d94df630d9bd86110e394d4844a57cd1240", "seminar_id": 1215, "time_of_addition": "Wed, Oct 07, 2020 18:20"}, "798": {"seminar_date": "Wed, Jun 17, 2020", "seminar_time": "13:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://us02web.zoom.us/j/88631841513?pwd=Q0M0VG1IZkpaRElycGV4L3hsWmJOQT09", "password": "258647", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Caswell Barry", "speaker_affil": "University College London", "speaker_twitter": "", "speaker_website": "https://www.ucl.ac.uk/biosciences/people/caswell-barry", "topic_tags": "AI, cortex, memory", "seminar_title": "The recruitment of spatial cells in large-scale space & an AI approach to neural discovery", "seminar_abstract": "Prof Caswell Barry, Professorial Research Fellow, Cell & Developmental Biology, Division of Biosciences, University College London. He and his team are trying to understand how the brain works - how it creates that experience of being human, and more specifically, how the brain creates, stores, and updates memories for places and events. They are trying to answer this is by studying areas of the brain linked to memory, the hippocampus and associated sections of cortex \u2013 by recording the activity of neurons in these areas we can visualise and hopefully understand the processes the trigger memory formation and retrieval.", "hosted_by": "Bristol Neuroscience", "domain": ["Neuroscience"], "calendar_event_hash": "66e4bed108b42c1c44e7628bc7de912c2b73737b4d2a2ed70360904eb39e8ccc", "seminar_id": 798, "time_of_addition": "Mon, Sep 28, 2020 11:06"}, "745": {"seminar_date": "Thu, Oct 1, 2020", "seminar_time": "14:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://zoom.us/j/93678591511?pwd=TmlNVTQ5SnlPa253L3RFV29kblROUT09", "password": "768528", "video_on_demand": "", "speaker_title": "", "seminar_speaker": "Christophe Mulle", "speaker_affil": "University of Bordeaux", "speaker_twitter": "", "speaker_website": "https://www.bordeaux-neurocampus.fr/staff/christophe-mulle/", "topic_tags": "synaptic plasticity, memory", "seminar_title": "Presynaptic plasticity in hippocampal circuits", "seminar_abstract": "Christophe Mulle is a cellular neurobiologist with expertise in electrophysiology of synaptic transmission and an international leader in studies on glutamate receptors and hippocampal synaptic plasticity. He was among the first to identify and characterize functional nicotinic receptors in the mammalian brain while working in the laboratory of Jean-Pierre Changeux at the Pasteur Institute. He then generated knock-out mice for KAR subunits at the Salk Institute in the laboratory of Steve Heinemann, which have proven to be instrumental for understanding the function of these elusive glutamate receptors in synaptic function and plasticity.", "hosted_by": "Bristol Neuroscience", "domain": ["Neuroscience"], "calendar_event_hash": "85f05cfd306280d99178ebfc7c989939dbb754570f272d41cd25ad2ae1087009", "seminar_id": 745, "time_of_addition": "Wed, Sep 23, 2020 09:50"}, "1154": {"seminar_date": "Tue, Oct 20, 2020", "seminar_time": "13:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://zoom.us/j/93678591511?pwd=TmlNVTQ5SnlPa253L3RFV29kblROUT09", "password": "576676", "video_on_demand": "", "speaker_title": "Drs", "seminar_speaker": "Harriet Ball, Liz Coulthard, Claire Rice", "speaker_affil": "University of Bristol", "speaker_twitter": "", "speaker_website": "http://www.bristol.ac.uk/neuroscience/events/2020/bnwebinar-20oct.html", "topic_tags": "neurology, COVID, sleep, neurodegeneration, cognition", "seminar_title": "Neurological consequences of COVID-19", "seminar_abstract": "The speakers will outline how neurologists in Bristol have been research-active during the COVID-19 pandemic including our contribution to national and international surveillance programmes as well as initiating research studies such as an evaluation of the impact of COVID anxiety on sleep and neurodegeneration and determining whether vascular changes in the eye predict COVID-19 severity.", "hosted_by": "Bristol Neuroscience", "domain": ["Neuroscience"], "calendar_event_hash": "79d7285b20a95def6b87c4248a94e4154969435458afb1deccd44f23a86bf699", "seminar_id": 1154, "time_of_addition": "Mon, Oct 05, 2020 15:40"}, "1155": {"seminar_date": "Tue, Nov 10, 2020", "seminar_time": "13:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://bristol-ac-uk-dev.zoom.us/j/94702478619?pwd=VUhXRmtDL0pVcVVOdEdyNXNoVEZXdz09", "password": "213479", "video_on_demand": "", "speaker_title": "Mrs", "seminar_speaker": "Meg Atwood", "speaker_affil": "University of Bristol", "speaker_twitter": "", "speaker_website": "http://www.bristol.ac.uk/neuroscience/events/2020/bnwebinar-10nov.html", "topic_tags": "adolescent, cognition, anxiety, mental health, COVID", "seminar_title": "Investigating the impact of the pandemic on adolescent anxiety and cognitive function", "seminar_abstract": "Meg was awarded funding to look into how the coronavirus pandemic has affected children's mental health and wellbeing.", "hosted_by": "Bristol Neuroscience", "domain": ["Neuroscience"], "calendar_event_hash": "79ab4dd374c83a84b170bbe8ccf54942f07d0f6650156e9e691469a973f163b3", "seminar_id": 1155, "time_of_addition": "Mon, Oct 05, 2020 15:45"}, "921": {"seminar_date": "Thu, Jul 30, 2020", "seminar_time": "12:00", "timezone": "America/Montreal", "posted": "yes", "seminar_link": "https://mcgill.zoom.us/j/96011792389", "password": "", "video_on_demand": "", "speaker_title": "Dr", "seminar_speaker": "Mihaela Iordanova", "speaker_affil": "Concordia University", "speaker_twitter": "", "speaker_website": "", "topic_tags": "neurophotonics", "seminar_title": "VTA DA transients regulate temporal-difference learning", "seminar_abstract": "", "hosted_by": "Neuro Light Lunch", "domain": ["Neuroscience"], "calendar_event_hash": "2b10dc3d104d6fd4fb8ac4f0cb8aaa000f380eccd4d5e8e8cbd99ae0e993f2e3", "seminar_id": 921, "time_of_addition": "Mon, Sep 28, 2020 11:08"}, "334": {"seminar_date": "Thu, Jul 9, 2020", "seminar_time": "12:00", "timezone": "America/Montreal", "posted": "yes", "seminar_link": "https://mcgill.zoom.us/j/96011792389", "password": "", "video_on_demand": "", "speaker_title": "Dr", "seminar_speaker": "Arjun Krishnaswamy", "speaker_affil": "McGill University", "speaker_twitter": "", "speaker_website": "", "topic_tags": "neurophotonics, retina", "seminar_title": "Optical approaches to study the assembly and function of retinal circuits", "seminar_abstract": "", "hosted_by": "Neuro Light Lunch", "domain": ["Neuroscience"], "calendar_event_hash": "5db2fbf1512fc7a3f4ad23da4a9846025413089136ccb49776970b4017dcd9d9", "seminar_id": 334, "time_of_addition": "Mon, Jul 06, 2020 03:45"}, "922": {"seminar_date": "Thu, Jul 16, 2020", "seminar_time": "12:00", "timezone": "America/Montreal", "posted": "yes", "seminar_link": "https://mcgill.zoom.us/j/96011792389", "password": "", "video_on_demand": "", "speaker_title": "Dr", "seminar_speaker": "Mark Brandon", "speaker_affil": "Douglas Mental Health University Institute", "speaker_twitter": "", "speaker_website": "", "topic_tags": "neurophotonics", "seminar_title": "Imaging the neural basis of cognition 1000 neurons at a time", "seminar_abstract": "", "hosted_by": "Neuro Light Lunch", "domain": ["Neuroscience"], "calendar_event_hash": "b0ab7501c869fb7e10553ef39eaf2e40acde3e65a03e0ff28489e23425de1d2d", "seminar_id": 922, "time_of_addition": "Mon, Sep 28, 2020 11:08"}, "923": {"seminar_date": "Thu, Jul 23, 2020", "seminar_time": "12:00", "timezone": "America/Montreal", "posted": "yes", "seminar_link": "https://mcgill.zoom.us/j/96011792389", "password": "", "video_on_demand": "", "speaker_title": "Dr", "seminar_speaker": "Kaspar Podgorski", "speaker_affil": "Janelia/SickKids", "speaker_twitter": "", "speaker_website": "", "topic_tags": "neurophotonics", "seminar_title": "Faster two-photon microscopy using digital micromirror devices", "seminar_abstract": "", "hosted_by": "Neuro Light Lunch", "domain": ["Neuroscience"], "calendar_event_hash": "62b5233f33c7d2add73926a809aa366ac225899973fc4052ca0aebf5e121a303", "seminar_id": 923, "time_of_addition": "Mon, Sep 28, 2020 11:08"}, "924": {"seminar_date": "Thu, Jul 30, 2020", "seminar_time": "12:30", "timezone": "America/Montreal", "posted": "yes", "seminar_link": "https://mcgill.zoom.us/j/96011792389", "password": "", "video_on_demand": "", "speaker_title": "Dr", "seminar_speaker": "Alex Lohman", "speaker_affil": "University of Calgary/HBI", "speaker_twitter": "", "speaker_website": "", "topic_tags": "neurophotonics", "seminar_title": "Novel optogenetic tools to investigate pannexin-1 signaling in the central nervous system", "seminar_abstract": "", "hosted_by": "Neuro Light Lunch", "domain": ["Neuroscience"], "calendar_event_hash": "7f872fb5b2b16ce98c215125360a78c97e8dc81292c89f5d9d12be84cd4a9b5a", "seminar_id": 924, "time_of_addition": "Mon, Sep 28, 2020 11:08"}, "925": {"seminar_date": "Thu, Jul 9, 2020", "seminar_time": "12:30", "timezone": "America/Montreal", "posted": "yes", "seminar_link": "https://mcgill.zoom.us/j/96011792389", "password": "", "video_on_demand": "", "speaker_title": "Dr", "seminar_speaker": "Tony Lim", "speaker_affil": "Montreal Neurological Institute", "speaker_twitter": "", "speaker_website": "", "topic_tags": "neurophotonics", "seminar_title": "Control of microglial-mediated axonal pruning by complement activating and inhibiting molecules", "seminar_abstract": "", "hosted_by": "Neuro Light Lunch", "domain": ["Neuroscience"], "calendar_event_hash": "567889a03b866981973f52b11be71adac8e44db314f23bc70e09eed60b0e0592", "seminar_id": 925, "time_of_addition": "Mon, Sep 28, 2020 11:08"}, "926": {"seminar_date": "Thu, Jul 16, 2020", "seminar_time": "12:30", "timezone": "America/Montreal", "posted": "yes", "seminar_link": "https://mcgill.zoom.us/j/96011792389", "password": "", "video_on_demand": "", "speaker_title": "Dr", "seminar_speaker": "Matilde Balbi", "speaker_affil": "UBC/U Queensland", "speaker_twitter": "", "speaker_website": "", "topic_tags": "neurophotonics", "seminar_title": "Multimodal approaches to assess optogenetically induced neuroprotection in the acute phase after stroke", "seminar_abstract": "", "hosted_by": "Neuro Light Lunch", "domain": ["Neuroscience"], "calendar_event_hash": "945afa390dc41db9ce95c5755dfb2a79239fba5126fc2270bbc4905ead4833b7", "seminar_id": 926, "time_of_addition": "Mon, Sep 28, 2020 11:08"}, "927": {"seminar_date": "Thu, Jul 23, 2020", "seminar_time": "12:30", "timezone": "America/Montreal", "posted": "yes", "seminar_link": "https://mcgill.zoom.us/j/96011792389", "password": "", "video_on_demand": "", "speaker_title": "Dr", "seminar_speaker": "Ahmed Abdelfattah", "speaker_affil": "Janelia Research Campus", "speaker_twitter": "", "speaker_website": "", "topic_tags": "neurophotonics", "seminar_title": "Genetically encoded voltage sensors for optical monitoring of brain activity", "seminar_abstract": "", "hosted_by": "Neuro Light Lunch", "domain": ["Neuroscience"], "calendar_event_hash": "491ec269cbf5f0f21117106bf94629547559986175b3efdd08a00391c9b94d6a", "seminar_id": 927, "time_of_addition": "Mon, Sep 28, 2020 11:08"}, "1148": {"seminar_date": "Fri, Oct 9, 2020", "seminar_time": "10:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/swc-symposium-2020/2", "password": "", "video_on_demand": "https://www.crowdcast.io/e/swc-symposium-2020/2", "speaker_title": "Dr", "seminar_speaker": "Juan \u00c1lvaro Gallego", "speaker_affil": "Imperial College London", "speaker_twitter": "@JAlGallego", "speaker_website": "https://gallego.bg.ic.ac.uk/", "topic_tags": "brain-machine interfaces, motor control", "seminar_title": "", "seminar_abstract": "", "hosted_by": "SWC Symposium", "domain": ["Neuroscience"], "calendar_event_hash": "2887de0257b85e1821bcc8cd7c4c8aeabbb38c1d09f495bc5d84195925bc7df6", "seminar_id": 1148, "time_of_addition": "Mon, Oct 05, 2020 13:20"}, "1149": {"seminar_date": "Fri, Oct 9, 2020", "seminar_time": "11:10", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/swc-symposium-2020/4", "password": "", "video_on_demand": "https://www.crowdcast.io/e/swc-symposium-2020/4", "speaker_title": "Prof", "seminar_speaker": "Tamar Makin & Danielle Clode", "speaker_affil": "University College London", "speaker_twitter": "@PlasticityUCL", "speaker_website": "https://plasticity-lab.com/", "topic_tags": "brain-machine interfaces, motor control", "seminar_title": "An interdisciplinary perspective on motor augmentation from neuroscience and design", "seminar_abstract": "By studying the neural correlates of hand augmentation, we are exploring the boundaries of neuroplasticity seeing how it can be harnessed to improve the usability and control of prosthetic devices. Tamar Makin and Dani Clode each discuss their research and perspectives within the field of prosthetics that has led to this unique collaboration and exploration of motor augmentation and the brain.", "hosted_by": "SWC Symposium", "domain": ["Neuroscience"], "calendar_event_hash": "afe23f48a17e7b0ddbefd2cc83d820232f92b81e6ff0eb752fdbd8e42e117965", "seminar_id": 1149, "time_of_addition": "Mon, Oct 05, 2020 13:20"}, "1150": {"seminar_date": "Fri, Oct 9, 2020", "seminar_time": "12:40", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/swc-symposium-2020/6", "password": "", "video_on_demand": "https://www.crowdcast.io/e/swc-symposium-2020/5", "speaker_title": "Dr", "seminar_speaker": "Kelly Clancy", "speaker_affil": "DeepMind", "speaker_twitter": "@kellybclancy", "speaker_website": "https://www.kellybclancy.com/", "topic_tags": "brain-machine interfaces, motor control", "seminar_title": "Understanding sensorimotor control at global and local scales", "seminar_abstract": "The brain is remarkably flexible, and appears to instantly reconfigure its processing depending on what\u2019s needed to solve a task at hand: fMRI studies indicate that distal brain areas appear to fluidly couple and decouple with one another depending on behavioral context. We investigated how the brain coordinates its activity across areas to inform complex, top-down control behaviors. Animals were trained to perform a novel brain machine interface task to guide a visual cursor to a reward zone, using activity recorded with widefield calcium imaging. This allowed us to screen for cortical areas implicated in causal neural control of the visual object. Animals could decorrelate normally highly-correlated areas to perform the task, and used an explore-exploit search in neural activity space to discover successful strategies. Higher visual and parietal areas were more active during the task in expert animals. Single unit recordings targeted to these areas indicated that the sensory representation of an object was sensitive to an animal\u2019s subjective sense of controlling it.", "hosted_by": "SWC Symposium", "domain": ["Neuroscience"], "calendar_event_hash": "8cc47d7a4809b155d0af5aa0dda224d78cb442334642958bb25b418a4d8ca4c7", "seminar_id": 1150, "time_of_addition": "Mon, Oct 05, 2020 13:20"}, "1151": {"seminar_date": "Fri, Oct 9, 2020", "seminar_time": "14:50", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/swc-symposium-2020/9", "password": "", "video_on_demand": "https://www.crowdcast.io/e/swc-symposium-2020/8", "speaker_title": "Prof", "seminar_speaker": "Aaron Batista", "speaker_affil": "University of Pittsburgh", "speaker_twitter": "@aaronbatista", "speaker_website": "https://smile.pitt.edu/", "topic_tags": "brain-machine interfaces, motor control", "seminar_title": "", "seminar_abstract": "", "hosted_by": "SWC Symposium", "domain": ["Neuroscience"], "calendar_event_hash": "d6c7694cede933e04923faf1e38300737e695c2afb30c6f9bd585cc99ad9f43d", "seminar_id": 1151, "time_of_addition": "Mon, Oct 05, 2020 13:20"}, "1152": {"seminar_date": "Fri, Oct 9, 2020", "seminar_time": "16:00", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/swc-symposium-2020/11", "password": "", "video_on_demand": "https://www.crowdcast.io/e/swc-symposium-2020/9", "speaker_title": "Dr", "seminar_speaker": "Amy Orsborn", "speaker_affil": "University of Washington", "speaker_twitter": "@neuroamyo", "speaker_website": "http://faculty.washington.edu/aorsborn/", "topic_tags": "brain-machine interfaces, motor control", "seminar_title": "Motor BMIs for probing sensorimotor control and parsing distributed learning", "seminar_abstract": "Brain-machine interfaces (BMIs) change how the brain sends and receives information from the environment, opening new ways to probe brain function. For instance, motor BMIs allow us to precisely define and manipulate the sensorimotor loop which has enabled new insights into motor control and learning. In this talk, I\u2019ll first present an example study where sensory-motor loop manipulations in BMI allowed us to probe feed-forward and feedback control mechanisms in ways that are not possible in the natural motor system. This study shed light on sensorimotor processing, and in turn led to state-of-the-art neural interface performance. I\u2019ll then survey recent work that highlights the likelihood that BMIs, much like natural motor learning, engages multiple distributed learning mechanisms that can be carefully interrogated with BMI.", "hosted_by": "SWC Symposium", "domain": ["Neuroscience"], "calendar_event_hash": "c141b509b0f32d52228ebe0440732b8b7182d09ecbe5c8080efd1917bda07529", "seminar_id": 1152, "time_of_addition": "Mon, Oct 05, 2020 13:20"}, "1153": {"seminar_date": "Fri, Oct 9, 2020", "seminar_time": "17:10", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/swc-symposium-2020/13", "password": "", "video_on_demand": "https://www.crowdcast.io/e/swc-symposium-2020/11", "speaker_title": "Dr", "seminar_speaker": "Edward Chang", "speaker_affil": "University of California, San Francisco", "speaker_twitter": "@ChangLabUcsf", "speaker_website": "http://changlab.ucsf.edu/", "topic_tags": "brain-machine interfaces, motor control", "seminar_title": "", "seminar_abstract": "", "hosted_by": "SWC Symposium", "domain": ["Neuroscience"], "calendar_event_hash": "37f08139549fa5e02bb5ec41e375dd67bd2b583488e40c841ecbe272d3873d48", "seminar_id": 1153, "time_of_addition": "Mon, Oct 05, 2020 13:20"}, "392": {"seminar_date": "Tue, May 12, 2020", "seminar_time": "12:00", "timezone": "Israel", "posted": "yes", "seminar_link": "https://zoom.us/j/93256421718", "password": "", "video_on_demand": "", "speaker_title": "Dr", "seminar_speaker": "Dori Derdikman", "speaker_affil": "Technion", "speaker_twitter": "", "speaker_website": "https://derdiklab.technion.ac.il/", "topic_tags": "vision, visual science, navigation, hippocampus", "seminar_title": "On places and borders in the brain", "seminar_abstract": "", "hosted_by": "BIU Vision Science", "domain": ["Neuroscience"], "calendar_event_hash": "7f3d8c5580ef2bf9cdfa76813b74d1492774dbf98977d02188ae3215acacbc6c", "seminar_id": 392, "time_of_addition": "Mon, Jul 20, 2020 20:55"}, "393": {"seminar_date": "Tue, May 26, 2020", "seminar_time": "12:00", "timezone": "Israel", "posted": "yes", "seminar_link": "https://zoom.us/j/96121774654", "password": "", "video_on_demand": "", "speaker_title": "Dr", "seminar_speaker": "Michal Rivlin", "speaker_affil": "Weizmann Inst. of Science", "speaker_twitter": "", "speaker_website": "https://www.weizmann.ac.il/neurobiology/labs/rivlin/home", "topic_tags": "vision, visual science, retina", "seminar_title": "Antagonistic Center-Surround Mechanisms for Direction Selectivity in the Retina", "seminar_abstract": "", "hosted_by": "BIU Vision Science", "domain": ["Neuroscience"], "calendar_event_hash": "77a45df719a91aab448f5da2c7c059fd24806bb5c20952049cc1eca958f068f5", "seminar_id": 393, "time_of_addition": "Mon, Jul 20, 2020 20:55"}, "394": {"seminar_date": "Tue, Jun 2, 2020", "seminar_time": "12:00", "timezone": "Israel", "posted": "yes", "seminar_link": "https://zoom.us/j/98772486151", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Ido Perlman", "speaker_affil": "Technion", "speaker_twitter": "", "speaker_website": "https://labnesium.com/Ido-Perlman-Lab/4761/", "topic_tags": "vision, visual science, retina, darkness, albino", "seminar_title": "Why prolonged darkness increases retinal susceptibility of albino rat to light damage", "seminar_abstract": "", "hosted_by": "BIU Vision Science", "domain": ["Neuroscience"], "calendar_event_hash": "eb5acb9e517ee8e79f1eb2ba768581e4b6ac4b0250cc92eb72cb131905798f4a", "seminar_id": 394, "time_of_addition": "Mon, Jul 20, 2020 20:55"}, "395": {"seminar_date": "Tue, Jun 9, 2020", "seminar_time": "12:00", "timezone": "Israel", "posted": "yes", "seminar_link": "https://zoom.us/j/98639649475", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Ifat Levy", "speaker_affil": "Yale", "speaker_twitter": "", "speaker_website": "https://medicine.yale.edu/lab/decision/", "topic_tags": "decision making, visual science, neuroeconomics, individual differences", "seminar_title": "Individual differences in decision-making under uncertainty: a neuroeconomic approach", "seminar_abstract": "", "hosted_by": "BIU Vision Science", "domain": ["Neuroscience"], "calendar_event_hash": "1c1edd98eff14884e30165c98ce34c7c2cf906388e7626382df68411b37eca9a", "seminar_id": 395, "time_of_addition": "Mon, Jul 20, 2020 20:55"}, "396": {"seminar_date": "Tue, Jun 16, 2020", "seminar_time": "12:00", "timezone": "Israel", "posted": "yes", "seminar_link": "https://zoom.us/j/96902889550", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Nurit Gronau", "speaker_affil": "Open University", "speaker_twitter": "", "speaker_website": "https://www.openu.ac.il/en/personalsites/NuritGronau.aspx", "topic_tags": "vision, attention, visual science", "seminar_title": "Vision at a glance:  The role of attention in object and scene categorization", "seminar_abstract": "", "hosted_by": "BIU Vision Science", "domain": ["Neuroscience"], "calendar_event_hash": "7816a8e831c66bb478096fb7c5d8c97e6920a8baf43969fcf68f7142f85eaf3a", "seminar_id": 396, "time_of_addition": "Mon, Jul 20, 2020 20:55"}, "387": {"seminar_date": "Tue, Jun 23, 2020", "seminar_time": "12:00", "timezone": "Israel", "posted": "yes", "seminar_link": "https://zoom.us/j/91640586227", "password": "", "video_on_demand": "https://youtu.be/ZF3aomDmmDc", "speaker_title": "", "seminar_speaker": "Itzik Normam", "speaker_affil": "Weizmann Inst. of Science", "speaker_twitter": "", "speaker_website": "", "topic_tags": "vision, visual science, episodic memory, hippocampus, ripples, ECoG", "seminar_title": "The Role of Hippocampal Sharp Wave Ripples in Human Episodic Memory", "seminar_abstract": "", "hosted_by": "BIU Vision Science", "domain": ["Neuroscience"], "calendar_event_hash": "eeb3cccfe8620cf2ad88af4677bda2f63402225dcb6dedf200cfbf94d15bfd68", "seminar_id": 387, "time_of_addition": "Mon, Jul 20, 2020 20:40"}, "397": {"seminar_date": "Tue, Jun 30, 2020", "seminar_time": "12:00", "timezone": "Israel", "posted": "yes", "seminar_link": "https://zoom.us/j/99872163649", "password": "", "video_on_demand": "https://youtu.be/eaJhGfuVReU", "speaker_title": "Dr", "seminar_speaker": "Danny Harari", "speaker_affil": "Weizmann Inst. of Science", "speaker_twitter": "", "speaker_website": "https://www.weizmann.ac.il/math/dannyh/", "topic_tags": "vision, visual science, machine learning", "seminar_title": "Minimal Images: Beyond \u2018Core Recognition", "seminar_abstract": "", "hosted_by": "BIU Vision Science", "domain": ["Neuroscience"], "calendar_event_hash": "e9de3cd7fda2730b70f73059596575b978989b5921e47a0a8664972d22730c7b", "seminar_id": 397, "time_of_addition": "Mon, Jul 20, 2020 20:55"}, "398": {"seminar_date": "Tue, Jul 7, 2020", "seminar_time": "12:00", "timezone": "Israel", "posted": "yes", "seminar_link": "https://zoom.us/j/98435372897", "password": "", "video_on_demand": "https://youtu.be/8PBAbWfBvVQ", "speaker_title": "Dr", "seminar_speaker": "Yasuto Tanaka", "speaker_affil": "Paris Miki Inc.  and Osaka University", "speaker_twitter": "", "speaker_website": "", "topic_tags": "vision, visual science, eye movements", "seminar_title": "Visual perception and fixational eye movements: microsaccades, drift and tremor", "seminar_abstract": "", "hosted_by": "BIU Vision Science", "domain": ["Neuroscience"], "calendar_event_hash": "9fe323b010a7abaa7755bdfd26e335f11aa93fcaf1f98fc529ba58aaf277c526", "seminar_id": 398, "time_of_addition": "Mon, Jul 20, 2020 20:55"}, "399": {"seminar_date": "Tue, Jul 14, 2020", "seminar_time": "15:00", "timezone": "Israel", "posted": "yes", "seminar_link": "https://zoom.us/j/91051654913", "password": "", "video_on_demand": "https://youtu.be/rzK__FSHEf0", "speaker_title": "Dr", "seminar_speaker": "Assaf Harel", "speaker_affil": "Wright State University", "speaker_twitter": "", "speaker_website": "https://people.wright.edu/assaf.harel", "topic_tags": "vision, visual science, ERPs", "seminar_title": "Uncovering the temporal dynamics of scene understanding using Event-Related Potentials", "seminar_abstract": "", "hosted_by": "BIU Vision Science", "domain": ["Neuroscience"], "calendar_event_hash": "84b90eeb86f6e951a7b44f87a5fecd6f45b09a2d7952fa017b0620376d56d1c1", "seminar_id": 399, "time_of_addition": "Mon, Jul 20, 2020 20:55"}, "400": {"seminar_date": "Tue, Jul 21, 2020", "seminar_time": "12:00", "timezone": "Israel", "posted": "yes", "seminar_link": "https://zoom.us/j/91236102770", "password": "", "video_on_demand": "https://youtu.be/3IFTAg2UA2A", "speaker_title": "Dr", "seminar_speaker": "Shlomit Ben Ami", "speaker_affil": "MIT and Project Prakash", "speaker_twitter": "", "speaker_website": "", "topic_tags": "vision, visual science, development, cognitive science", "seminar_title": "Learning to See Biological Motion", "seminar_abstract": "", "hosted_by": "BIU Vision Science", "domain": ["Neuroscience"], "calendar_event_hash": "82e7c2995d12c6d6db38c49c7dc4f1ff4fccac0514ed3259516b0e9d278b64d8", "seminar_id": 400, "time_of_addition": "Mon, Jul 20, 2020 20:55"}, "401": {"seminar_date": "Tue, Jul 28, 2020", "seminar_time": "12:00", "timezone": "Israel", "posted": "yes", "seminar_link": "https://zoom.us/j/99699334341", "password": "", "video_on_demand": "https://youtu.be/JKzUTYwh664", "speaker_title": "Prof", "seminar_speaker": "Michael Herzog", "speaker_affil": "EPFL", "speaker_twitter": "", "speaker_website": "https://www.epfl.ch/labs/lpsy/team/herzog/", "topic_tags": "vision, visual science, cognitive science, faces", "seminar_title": "Crowding, Patterns & The Fundamentals of Vision", "seminar_abstract": "", "hosted_by": "BIU Vision Science", "domain": ["Neuroscience"], "calendar_event_hash": "4f091363fb358bb91a5122424e48de685b05ec3df9fab6a41b49eed8e8044ee4", "seminar_id": 401, "time_of_addition": "Mon, Jul 20, 2020 20:55"}, "412": {"seminar_date": "Tue, Aug 4, 2020", "seminar_time": "12:00", "timezone": "Israel", "posted": "yes", "seminar_link": "https://zoom.us/j/91150688208", "password": "", "video_on_demand": "https://youtu.be/E1UPdvUb_9w", "speaker_title": "Dr", "seminar_speaker": "Meike Ramon", "speaker_affil": "University of Fribourg", "speaker_twitter": "", "speaker_website": "http://www.meikeramon.com/", "topic_tags": "vision, visual science, cognitive science", "seminar_title": "Super-Recognizers: facts, fallacies, and the future", "seminar_abstract": "Over the past decade, the domain of face identity processing has seen a surging interest in inter-individual differences, with a focus on individuals with superior skills, so-called Super-Recognizers (SRs; Ramon et al., 2019; Russell et al., 2009). Their study can provide valuable insights into brain-behavior relationships and advance our understanding of neural functioning. Despite a decade of research, and similarly to the field of developmental prosopagnosia, a consensus on diagnostic criteria for SR identification is lacking. Consequently, SRs are currently identified either inconsistently, via suboptimal individual tests, or via undocumented collections of tests. This state of the field has two major implications. Firstly, our scientific understanding of SRs will remain at best limited. Secondly, the needs of government agencies interested in deploying SRs for real-life identity verification (e.g., policing) are unlikely to be met. To counteract these issues, I suggest the following action points. Firstly, based on our and others\u2019 work suggesting novel and challenging tests of face cognition (Bobak et al., 2019; Fysh et al., in press; Stacchi et al., 2019), and my collaborations with international security agencies, I recommend novel diagnostic criteria for SR identification. These are currently being used to screen the Berlin State Police\u2019s >25K employees before identifying SRs via bespoke testing procedures we have collaboratively developed over the past years. Secondly, I introduce a cohort of SRs identified using these criteria, which is being studied in-depth using behavioral methods, psychophysics, eye-tracking, and neuroimaging. Finally, I suggest data acquired for these individuals should be curated to develop and share best practices with researchers and practitioners, and to gain an accurate and transparent description of SR cases to exploit their informative value.", "hosted_by": "BIU Vision Science", "domain": ["Neuroscience"], "calendar_event_hash": "e2da02a439812766843ef9f76de74a05104e5a6ffc281daac1af99f3cc3912fc", "seminar_id": 412, "time_of_addition": "Thu, Jul 30, 2020 13:05"}, "418": {"seminar_date": "Tue, Sep 1, 2020", "seminar_time": "15:00", "timezone": "Israel", "posted": "yes", "seminar_link": "https://zoom.us/j/91790244801", "password": "", "video_on_demand": "https://youtu.be/vEP0x_RIl0M", "speaker_title": "Prof", "seminar_speaker": "Tony Movshon", "speaker_affil": "NYU", "speaker_twitter": "@TonyMovshon", "speaker_website": "https://as.nyu.edu/cns/people/faculty.j-anthony-movshon.html", "topic_tags": "vision, visual science, electrophysiology, motion, MT/V5, perception", "seminar_title": "Brain mechanisms of visual form perception", "seminar_abstract": "", "hosted_by": "BIU Vision Science", "domain": ["Neuroscience"], "calendar_event_hash": "76a2865f57c06990ea4ff6c4fae3e7eb0d14764967839b256a479020c6fa99a6", "seminar_id": 418, "time_of_addition": "Thu, Aug 06, 2020 00:45"}, "419": {"seminar_date": "Tue, Sep 8, 2020", "seminar_time": "15:00", "timezone": "Israel", "posted": "yes", "seminar_link": "https://zoom.us/j/97615934514", "password": "", "video_on_demand": "https://youtu.be/EbFkPk7Q3Z8", "speaker_title": "Prof", "seminar_speaker": "Mel Goodale", "speaker_affil": "Western University", "speaker_twitter": "@action_brain", "speaker_website": "https://www.uwo.ca/bmi/goodalelab/", "topic_tags": "vision, visual science, cognitive science, perception", "seminar_title": "How big is that banana?  Differences in size constancy for perception and action", "seminar_abstract": "", "hosted_by": "BIU Vision Science", "domain": ["Neuroscience"], "calendar_event_hash": "cd4bf6d16996e4ebb7088cceb3cec2ea2f7602a6522e6d9d88989cd3c8f75944", "seminar_id": 419, "time_of_addition": "Thu, Aug 06, 2020 00:45"}, "469": {"seminar_date": "Tue, Sep 15, 2020", "seminar_time": "15:00", "timezone": "Israel", "posted": "yes", "seminar_link": "https://zoom.us/j/98914203250", "password": "", "video_on_demand": "https://youtu.be/mSosHyc9M0k", "speaker_title": "Prof", "seminar_speaker": "Daphne Maurer", "speaker_affil": "McMaster University", "speaker_twitter": "", "speaker_website": "https://www.science.mcmaster.ca/pnb/department/dm.html", "topic_tags": "vision, visual science, development, cognitive science, perception", "seminar_title": "How the baby learns to see: Critical periods re-visited", "seminar_abstract": "", "hosted_by": "BIU Vision Science", "domain": ["Neuroscience"], "calendar_event_hash": "d8ab49c3ede2cd6daa55fd1541a00f974ac7f577f9bc994314af92497e856574", "seminar_id": 469, "time_of_addition": "Sat, Aug 15, 2020 18:05"}, "421": {"seminar_date": "Tue, Oct 20, 2020", "seminar_time": "12:00", "timezone": "Israel", "posted": "yes", "seminar_link": "https://zoom.us/j/92734160566", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Rafi Malach", "speaker_affil": "Weizmann Inst. of Science", "speaker_twitter": "@rafi_malach", "speaker_website": "https://www.weizmann.ac.il/neurobiology/labs/malach/home", "topic_tags": "vision, visual science, cognitive science, perception", "seminar_title": "A structuralist perspective on the neuronal basis of human visual perception", "seminar_abstract": "", "hosted_by": "BIU Vision Science", "domain": ["Neuroscience"], "calendar_event_hash": "aaafb1744b2844decd6f7ad5920bb9016ea13ba5e108efb033a423830fe3b10b", "seminar_id": 421, "time_of_addition": "Thu, Aug 06, 2020 00:45"}, "650": {"seminar_date": "Tue, Oct 27, 2020", "seminar_time": "12:00", "timezone": "Israel", "posted": "yes", "seminar_link": "https://zoom.us/j/97280345546", "password": "", "video_on_demand": "", "speaker_title": "Profs", "seminar_speaker": "Janette Atkinson & Oliver Braddick", "speaker_affil": "UCL & Oxford", "speaker_twitter": "", "speaker_website": "https://www.thebritishacademy.ac.uk/fellows/janette-atkinson-FBA/", "topic_tags": "vision, visual science, development, cognitive science, perception", "seminar_title": "The developing visual brain \u2013 answers and questions", "seminar_abstract": "We will start our talk with a short video of our research, illustrating methods (some old and new)  and findings that have provided our current understanding of how visual capabilities develop in infancy and early childhood.  However, our research poses some outstanding questions.  We will briefly discuss three issues, which are linked by a common focus on the development of visual attentional processing:    (1) How do recurrent cortical loops contribute to development?  Cortical selectivity (e.g., to orientation, motion, and binocular disparity) develops in the early months of life.  However, these systems are not purely feedforward but depend on parallel pathways, with recurrent feedback loops playing a critical role.  The development of diverse networks, particularly for motion processing, may explain changes in dynamic responses and resolve developmental data obtained with different methodologies.  One possible role for these loops is in top-down attentional control of visual processing. (2) Why do hyperopic infants become strabismic (cross-eyes)?  Binocular interaction is a particularly sensitive area of development.  Standard clinical accounts suppose that long-sighted (hyperopic) refractive errors require accommodative effort, putting stress on the accommodation-convergence link that leads to its breakdown and strabismus.   Our large-scale population screening studies of 9-month infants question this:  hyperopic infants are at higher risk of strabismus and impaired vision (amblyopia and impaired attention) but these hyperopic infants often under- rather than over-accommodate.  This poor accommodation may reflect poor early attention processing, possibly a \u2018soft sign\u2019 of subtle cerebral dysfunction. (3) What do many neurodevelopmental disorders have in common? Despite similar cognitive demands, global motion perception is much more impaired than global static form across diverse neurodevelopmental disorders including Down and Williams Syndromes, Fragile-X, Autism, children with premature birth and infants with perinatal brain injury. These deficits in motion processing are associated with deficits in other dorsal stream functions such as visuo-motor co-ordination and attentional control, a cluster we have called \u2018dorsal stream vulnerability\u2019.  However, our neuroimaging measures related to motion coherence in typically developing children suggest that the critical areas for individual differences in global motion sensitivity are not early motion-processing areas such as V5/MT, but downstream parietal and frontal areas for decision processes on motion signals.  Although these brain networks  may also underlie attentional and visuo-motor deficits , we still do not know when and how these deficits  differ across different disorders and between individual children.    Answering these questions provide necessary steps, not only increasing our scientific understanding of human visual brain development,  but also in designing appropriate  interventions to help each child achieve their full potential.", "hosted_by": "BIU Vision Science", "domain": ["Neuroscience"], "calendar_event_hash": "c00c5b7c2c7e9d11fa791c26d23e34ce7c8762e550012998b6eef0e39e049efe", "seminar_id": 650, "time_of_addition": "Sun, Sep 13, 2020 01:40"}, "423": {"seminar_date": "Tue, Nov 3, 2020", "seminar_time": "12:00", "timezone": "Israel", "posted": "yes", "seminar_link": "https://zoom.us/j/93337303578", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Julie Harris", "speaker_affil": "University of St Andrews", "speaker_twitter": "", "speaker_website": "https://julieharrislab.wp.st-andrews.ac.uk/", "topic_tags": "vision, visual science, psychology, computer vision", "seminar_title": "", "seminar_abstract": "", "hosted_by": "BIU Vision Science", 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"https://zoom.us/j/96225781579", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Patrick Cavanagh", "speaker_affil": "Harvard", "speaker_twitter": "", "speaker_website": "https://cavlab.net/", "topic_tags": "vision, visual science, cognitive science, perception, attention, crowding", "seminar_title": "", "seminar_abstract": "", "hosted_by": "BIU Vision Science", "domain": ["Neuroscience"], "calendar_event_hash": "5b206349d290ee8f5c7de63fb044a3a98eb44d4d8d502125f5a54429cf103904", "seminar_id": 572, "time_of_addition": "Thu, Sep 03, 2020 12:55"}, "575": {"seminar_date": "Tue, Jul 20, 2021", "seminar_time": "15:00", "timezone": "Israel", "posted": "yes", "seminar_link": "https://zoom.us/j/97248200675", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Elizabeth Quinlan", "speaker_affil": "University of Maryland", "speaker_twitter": "", "speaker_website": "", "topic_tags": "", "seminar_title": "", "seminar_abstract": "", "hosted_by": "BIU Vision Science", "domain": ["Neuroscience"], "calendar_event_hash": "6fa92132954f80010e819b08a63e0c7e76607a80f0013b721f1a48f014349db4", "seminar_id": 575, "time_of_addition": "Fri, Sep 04, 2020 00:10"}, "743": {"seminar_date": "Tue, Jul 27, 2021", "seminar_time": "12:00", "timezone": "Israel", "posted": "yes", "seminar_link": "https://zoom.us/j/92118038266", "password": "", "video_on_demand": "", "speaker_title": "Prof", "seminar_speaker": "Jos\u00e9-Alain Sahel", "speaker_affil": "University of Pittsburgh", "speaker_twitter": "", "speaker_website": "https://mirm-pitt.net/our-people/faculty-staff-bios/jose-alain-sahel-md/", "topic_tags": "vision, vision restoration, retina, visual science", "seminar_title": "", "seminar_abstract": "", "hosted_by": "BIU Vision Science", "domain": ["Neuroscience"], "calendar_event_hash": "78ff4d2797a7ff3d0bcf74b9f53941b1e6b7ef10a367d455bf15a66e656f933b", "seminar_id": 743, "time_of_addition": "Tue, Sep 22, 2020 20:10"}, "889": {"seminar_date": "Tue, May 12, 2020", "seminar_time": "14:00", "timezone": "Europe/Vienna", "posted": "yes", "seminar_link": "https://istaustria.zoom.us/j/99213372643?pwd=TjQvRDhzTUZnQkQwM0p0bld4c1BPUT09", "password": "977855", "video_on_demand": "https://istaustria.zoom.us/rec/play/v8d8cuj-pj03E92StwSDC_ZwW46_KPmshndN__sIyE-3VXBRM1SvNbpHN7ZxKACAwLOtA5g4nBQ3VICk?startTime=1589284828000&_x_zm_rtaid=PPXPdvTTTdCmHPPCBuODRA.1589298715597.b3336d33255afe62f4c5e8621f6571a5&_x_zm_rhtaid=90", "speaker_title": "Prof", "seminar_speaker": "Rafael Yuste", "speaker_affil": "Columbia University", "speaker_twitter": "", "speaker_website": "", "topic_tags": "two-photon imaging, neural ensembles, optogenetics", "seminar_title": "Playing the piano with the cortex: role of neuronal ensembles and pattern completion in perception", "seminar_abstract": "The design of neural circuits, with large numbers of neurons interconnected in vast networks, strongly suggest that they are specifically build to generate emergent functional properties (1). To explore this hypothesis, we have developed two-photon holographic methods to selective image and manipulate the activity of neuronal populations in 3D in vivo (2). Using them we find that groups of synchronous neurons (neuronal ensembles) dominate the evoked and spontaneous activity of mouse primary visual cortex (3). Ensembles can be optogenetically imprinted for several days and some of their neurons trigger the entire ensemble (4). By activating these pattern completion cells in ensembles involved in visual discrimination paradigms, we can bi-directionally alter behavioural choices (5).  Our results demonstrate that ensembles are necessary and sufficient for visual perception and are consistent with the possibility that neuronal ensembles are the functional building blocks of cortical circuits. \n\n1.\tR. Yuste, From the neuron doctrine to neural networks. Nat Rev Neurosci 16, 487-497 (2015).\n2.\tL. Carrillo-Reid, W. Yang, J. E. Kang Miller, D. S. Peterka, R. Yuste, Imaging and Optically Manipulating Neuronal Ensembles. Annu Rev Biophys,  46: 271-293 (2017). \n3.\tJ. E. Miller, I. Ayzenshtat, L. Carrillo-Reid, R. Yuste, Visual stimuli recruit intrinsically generated cortical ensembles. Proceedings of the National Academy of Sciences of the United States of America 111, E4053-4061 (2014).\n4.\tL. Carrillo-Reid, W. Yang, Y. Bando, D. S. Peterka, R. Yuste, Imprinting and recalling cortical ensembles. Science 353, 691-694 (2016).\n5.\tL. Carrillo-Reid, S. Han, W. Yang, A. Akrouh, R. Yuste, (2019). Controlling visually-guided behaviour by holographic recalling of cortical ensembles. Cell 178, 447-457. DOI:https://doi.org/10.1016/j.cell.2019.05.045.", "hosted_by": "IST Neuroscience", "domain": ["Neuroscience"], "calendar_event_hash": "9b37d8223446a6cd4c02d948be511b0b9822d379add233b964ecc61c6d941a0c", "seminar_id": 889, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "890": {"seminar_date": "Tue, Jun 2, 2020", "seminar_time": "14:00", "timezone": "Europe/Vienna", "posted": "yes", "seminar_link": "https://istaustria.zoom.us/j/94819824190?pwd=TEsvSzdYUmYxRzlQVlNiVVlOYms0Zz09", "password": "283739", "video_on_demand": "https://istaustria.zoom.us/rec/play/vp14I-v8qj03TIbG5QSDBvQrW425LKis0iUeq6UPykq2ViMCYFXzM7JAM-Vp9zA8PuKiSZaboU-QxNMV?startTime=1591099176000", "speaker_title": "Prof", "seminar_speaker": "Gasper Tkacik", "speaker_affil": "Institute of Science and Technology Austria", "speaker_twitter": "", "speaker_website": "https://gtkacik.pages.ist.ac.at/", "topic_tags": "theory, bayes", "seminar_title": "Spanning the arc between optimality theories and data", "seminar_abstract": "Ideas about optimization are at the core of how we approach biological complexity. Quantitative predictions about biological systems have been successfully derived from first principles in the context of efficient coding, metabolic and transport networks, evolution, reinforcement learning, and decision making, by postulating that a system has evolved to optimize some utility function under biophysical constraints. Yet as normative theories become increasingly high-dimensional and optimal solutions stop being unique, it gets progressively hard to judge whether theoretical predictions are consistent with, or \"close to\", data. I will illustrate these issues using efficient coding applied to simple neuronal models as well as to a complex and realistic biochemical reaction network. As a solution, we developed a statistical framework which smoothly interpolates between ab initio optimality predictions and Bayesian parameter inference from data, while also permitting statistically rigorous tests of optimality hypotheses.", "hosted_by": "IST Neuroscience", "domain": ["Neuroscience"], "calendar_event_hash": "38b431856614506a051423ffcffbc96047e3cfbfbcdd25a2a811888388a94e97", "seminar_id": 890, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "523": {"seminar_date": "Fri, Sep 11, 2020", "seminar_time": "9:00", "timezone": "America/New_York", "posted": "yes", "seminar_link": "https://dibs.duke.edu/duke-visionfest-2020-virtual-event-sept-11", "password": "", "video_on_demand": "", "speaker_title": "Dr.", "seminar_speaker": "Joseph Carroll", "speaker_affil": "Medical College of Wisconsin", "speaker_twitter": "", "speaker_website": "https://dibs.duke.edu/duke-visionfest-2020", "topic_tags": "vision, visual science, retina", "seminar_title": "Duke VisionFest Symposium Keynote: Applications of High-Resolution Retinal Imaging", "seminar_abstract": "Duke VisionFest is a virtual research symposium conceived to bring together the many Duke groups studying aspects of the visual system. Keynote by Dr. Joseph Carroll, Medical College of Wisconsin, and featuring talks ranging from photoreceptor biology to visual system evolution to clinical diagnosis. Pre-registration is required to attend but open to anyone interested.", "hosted_by": "Duke VisionFest", "domain": ["Neuroscience"], "calendar_event_hash": "dd0230abb473c433526e718867ed89b4015436226c0bb072e892edf186ff7502", "seminar_id": 523, "time_of_addition": "Wed, Aug 26, 2020 15:00"}, "1160": {"seminar_date": "Wed, Jul 15, 2020", "seminar_time": "13:45", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://us02web.zoom.us/j/194382755?pwd=NUlaQVo4b0xLVE0xNGJmSDhoenA3Zz09", "password": "", "video_on_demand": "", "speaker_title": "", "seminar_speaker": "Georg Keller", "speaker_affil": "Friedrich Miescher Institute for Biomedical Research", "speaker_twitter": "@georg98keller", "speaker_website": "https://www.fmi.ch/research-groups/groupleader.html?group=131", "topic_tags": "predictive processing cortex", "seminar_title": "Predictive processing in cortical circuits", "seminar_abstract": "", "hosted_by": "Transatlantic Systems Neuro", "domain": ["Neuroscience"], "calendar_event_hash": "79b43dab2e27af46c9fadb5674a69066f7a928d8dd0d58775832bfabd3679d3a", "seminar_id": 1160, "time_of_addition": "Tue, Oct 06, 2020 12:30"}, "1161": {"seminar_date": "Wed, Jul 22, 2020", "seminar_time": "14:30", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://us02web.zoom.us/j/194382755?pwd=NUlaQVo4b0xLVE0xNGJmSDhoenA3Zz09", "password": "nol1917", "video_on_demand": "", "speaker_title": "", "seminar_speaker": "Jennifer Bussell", "speaker_affil": "Columbia University", "speaker_twitter": "@jbschiff", "speaker_website": "http://www.jenniferbussell.org/", "topic_tags": "exploration mice curiosity", "seminar_title": "The Desire to Know: Non-Instrumental Information Seeking in Mice", "seminar_abstract": "Animals are motivated to acquire knowledge. A particularly striking example is information seeking behavior: animals often seek out sensory cues that will inform them about the properties of uncertain future rewards, even when there is no way for them to use this information to influence the reward outcome, and even when this information comes at a considerable cost. Evidence from monkey electrophysiology and human fMRI studies suggests that orbitofrontal cortex and midbrain dopamine neurons represent the subjective value of knowledge during information seeking behavior. However, it remains unclear how the brain assigns value to information and how it integrates this with other incentives to drive behavior. We have therefore developed a task to test if information preferences are present in mice and study how informational value is imparted on stimuli. Mice are trained to enter a center port and receive an initial odor that instructs them to either go to an informative side port, go to an uninformative side port, or choose freely between them. The chosen side port then yields a second odor cue followed by a delayed probabilistic water reward. The informative port\u2019s odor cue indicates whether the upcoming reward will be big or small. The uninformative port\u2019s odor cue is uncorrelated with the trial outcome. Crucially, the two ports only differ in their odor cues, not in their water value since both offer identical probabilities of big and small rewards. We find that mice prefer the informative port. This preference is evident as a higher percentage choice of the informative port when given a free choice (67% +/- 1.7%, n = 14, p < 0.03), as well as by faster reaction times when instructed to go to the informative port (544ms +/- 21ms vs 795ms +/- 21ms, n = 14, p < 0.001). The preference for information is robust to within-animal reversals of informative and uninformative port locations, and, moreover, mice are willing to pay for information by choosing the informative port even if its reward amount is reduced to be substantially lower than the uninformative port. These behavioral observations suggest that odor stimuli are imparted with informational value as mice learn the information seeking task. We are currently imaging neural activity in orbitofrontal cortex with microendoscopes to identify changes in neural activity that may reflect value associated with the acquisition of knowledge.", "hosted_by": "Transatlantic Systems Neuro", "domain": ["Neuroscience"], "calendar_event_hash": "eed4e2698531ad1da015c173df4a1afc4db72f32027eac9a4b9700e40f606791", "seminar_id": 1161, "time_of_addition": "Tue, Oct 06, 2020 12:30"}, "1162": {"seminar_date": "Wed, Jul 29, 2020", "seminar_time": "14:30", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://us02web.zoom.us/j/194382755?pwd=NUlaQVo4b0xLVE0xNGJmSDhoenA3Zz09", "password": "nol1917", "video_on_demand": "", "speaker_title": "", "seminar_speaker": "Duda Kvitsiani", "speaker_affil": "Aarhus University", "speaker_twitter": "@DudaKvitsiani", "speaker_website": "https://dandrite.au.dk/people/group-leaders/kvitsiani-group/", "topic_tags": "drosophila foraging", "seminar_title": "Reward foraging task, and model-based analysis reveal how fruit flies learn the value of available options", "seminar_abstract": "Understanding what drives foraging decisions in animals requires careful manipulation of the value of available options while monitoring animal choices. Value-based decision-making tasks, in combination with formal learning models, have provided both an experimental and theoretical framework to study foraging decisions in lab settings. While these approaches were successfully used in the past to understand what drives choices in mammals, very little work has been done on fruit flies. This is even though fruit flies have served as a model organism for many complex behavioural paradigms. To fill this gap we developed a single-animal, trial-based decision-making task, where freely walking flies experienced optogenetic sugar-receptor neuron stimulation. We controlled the value of available options by manipulating the probabilities of optogenetic stimulation. We show that flies integrate a reward history of chosen options and forget value of unchosen options. We further discover that flies assign higher values to rewards experienced early in the behavioural session, consistent with formal reinforcement learning models. Finally, we show that the probabilistic rewards affect walking trajectories of flies, suggesting that accumulated value is controlling the navigation vector of flies in a graded fashion. These findings establish the fruit fly as a model organism to explore the genetic and circuit basis of value-based decisions.", "hosted_by": "Transatlantic Systems Neuro", "domain": ["Neuroscience"], "calendar_event_hash": "7c67ae81df5dd935c18a53f1e8d6f1d0cf1fef905f619b1feccb29e5536f62a3", "seminar_id": 1162, "time_of_addition": "Tue, Oct 06, 2020 12:30"}, "1163": {"seminar_date": "Wed, Sep 9, 2020", "seminar_time": "14:30", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://us02web.zoom.us/j/194382755?pwd=c2I4bGx3Nnloa2pNQ3ZvaDg5WldPdz09", "password": "nol1917", "video_on_demand": "", "speaker_title": "", "seminar_speaker": "Arkarup Banerjee", "speaker_affil": "NYU Langone medical center", "speaker_twitter": "", "speaker_website": "https://scholar.google.com/citations?user=VrbcQ7QAAAAJ&hl=en", "topic_tags": "", "seminar_title": "Motor Cortical Control of Vocal Interactions in a Neotropical Singing Mouse", "seminar_abstract": "Using sounds for social interactions is common across many taxa. Humans engaged in conversation, for\nexample, take rapid turns to go back and forth. This ability to act upon sensory information to generate a\ndesired motor output is a fundamental feature of animal behavior. How the brain enables such flexible\nsensorimotor transformations, for example during vocal interactions, is a central question in neuroscience.\nSeeking a rodent model to fill this niche, we are investigating neural mechanisms of vocal interaction in\nAlston\u2019s singing mouse (Scotinomys teguina) \u2013 a neotropical rodent native to the cloud forests of Central\nAmerica. We discovered sub-second temporal coordination of advertisement songs (counter-singing)\nbetween males of this species \u2013 a behavior that requires the rapid modification of motor outputs in response\nto auditory cues. We leveraged this natural behavior to probe the neural mechanisms that generate and allow\nfast and flexible vocal communication. Using causal manipulations, we recently showed that an orofacial\nmotor cortical area (OMC) in this rodent is required for vocal interactions (Okobi*, Banerjee* et. al, 2019).\nSubsequently, in electrophysiological recordings, I find neurons in OMC that track initiation, termination\nand relative timing of songs. Interestingly, persistent neural dynamics during song progression stretches or\ncompresses on every trial to match the total song duration (Banerjee et al, in preparation). These results\ndemonstrate robust cortical control of vocal timing in a rodent and upends the current dogma that motor\ncortical control of vocal output is evolutionarily restricted to the primate lineage.", "hosted_by": "Transatlantic Systems Neuro", "domain": ["Neuroscience"], "calendar_event_hash": "c071b082f6241ace762f95d6f630a88a9a4cedd10daee8784bd362cf745f0384", "seminar_id": 1163, "time_of_addition": "Tue, Oct 06, 2020 12:30"}, "1164": {"seminar_date": "Wed, Sep 16, 2020", "seminar_time": "14:30", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://us02web.zoom.us/j/194382755?pwd=c2I4bGx3Nnloa2pNQ3ZvaDg5WldPdz09", "password": "nol1917", "video_on_demand": "", "speaker_title": "", "seminar_speaker": "Jesse Golberg", "speaker_affil": "Cornell University", "speaker_twitter": "@jesseglab", "speaker_website": "https://sites.google.com/view/goldberg-lab/home", "topic_tags": "", "seminar_title": "Male songbirds turn off their self-evaluation systems when they sing to females", "seminar_abstract": "Attending to mistakes while practicing alone provides opportunities for learning but self-evaluation during audience-directed performance could distract from ongoing execution. It remains unknown how animals switch between practice and performance modes, and how evaluation systems process errors across distinct performance contexts. We recorded from striatal-projecting dopamine (DA) neurons as male songbirds transitioned from singing alone to singing female-directed courtship song. In the presence of the female, singing-related performance error signals were reduced or gated off and DA neurons were instead phasically activated by female vocalizations. Mesostriatal DA neurons can thus dynamically change their tuning with changes in social context.", "hosted_by": "Transatlantic Systems Neuro", "domain": ["Neuroscience"], "calendar_event_hash": "46ef9b94ffead9f659ab9240f4ba300315052ec5862c8b2f0627ef3b55e76d35", "seminar_id": 1164, "time_of_addition": "Tue, Oct 06, 2020 12:30"}, "1165": {"seminar_date": "Wed, Sep 23, 2020", "seminar_time": "14:30", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://us02web.zoom.us/j/194382755?pwd=c2I4bGx3Nnloa2pNQ3ZvaDg5WldPdz09", "password": "nol1917", "video_on_demand": "", "speaker_title": "", "seminar_speaker": "Romain Brette", "speaker_affil": "Institut de la Vision, Universit\u00e9 Pierre-and-Marie-Curie", "speaker_twitter": "https://twitter.com/romainbrette", "speaker_website": "http://romainbrette.fr/", "topic_tags": "paramecium modelling neuron", "seminar_title": "Integrative modeling of Paramecium, a swimming neuron", "seminar_abstract": "Paramecium is a unicellular organism that swims in fresh water using cilia. When it is stimulated (mechanically, chemically, optically, thermally, etc), it often swims backward then turns and swims forward again: this is called the avoiding reaction. This reaction is triggered by a calcium-based action potential. For this reason, it enjoyed a period of glory in the 1970s as a model organism for neuroscience. I will describe the behavior and electrophysiology of this \u201cswimming neuron\u201d, then I will present our ongoing attempts at developing an integrative quantitative model of Paramecium.", "hosted_by": "Transatlantic Systems Neuro", "domain": ["Neuroscience"], "calendar_event_hash": "24d68fa87b7104d7a57ef92ae4952b6a684b259cd08e3cf8658785ff4bc827a7", "seminar_id": 1165, "time_of_addition": "Tue, Oct 06, 2020 12:30"}, "1166": {"seminar_date": "Wed, Sep 30, 2020", "seminar_time": "14:30", "timezone": "Europe/London", "posted": "yes", "seminar_link": "https://us02web.zoom.us/j/194382755?pwd=c2I4bGx3Nnloa2pNQ3ZvaDg5WldPdz09", "password": "nol1918", "video_on_demand": "", "speaker_title": "", "seminar_speaker": "Jacqueline Gottlieb", "speaker_affil": "Columbia University", "speaker_twitter": "", "speaker_website": "https://www.gottlieblab.com/", "topic_tags": "", "seminar_title": "Attentional mechanisms in information seeking behaviors", "seminar_abstract": "", "hosted_by": "Transatlantic Systems Neuro", "domain": ["Neuroscience"], "calendar_event_hash": "8e20ee5e9ccbb734eae2fbf5859a7fd9ef706049f0ab330fdaff346c6f7c6b6a", "seminar_id": 1166, "time_of_addition": "Tue, Oct 06, 2020 12:30"}, "880": {"seminar_date": "Thu, Jun 25, 2020", "seminar_time": "14:00", "timezone": "Europe/Zurich", "posted": "yes", "seminar_link": "https://epfl.zoom.us/j/93924338902", "password": "", "video_on_demand": "", "speaker_title": "Dr", "seminar_speaker": "Johannes Felsenberg, Dr Marlen Knobloch, Dr Sami El-Boustani", "speaker_affil": "The Friedrich Miescher Institute for Biomedical Research, Universit\u00e9yof Lausanne, University of  Geneva", "speaker_twitter": "", "speaker_website": "", "topic_tags": "systems, memory, neurogenesis, open neuroscience", "seminar_title": "\u201cChanging Memory on the Fly, re-evaluation of learned behaviour I n Drosophila\u201d\n\u201cMetabolic Regulation of Neural Stem Cells\u201d\n\u201cThe answer is in the sauce\u201d", "seminar_abstract": "", "hosted_by": "ySSN NeuroRoutes", "domain": ["Neuroscience"], "calendar_event_hash": "ebce5ed062f433b763fa38991e69de464cb12a3038fe4766ceca277f2e521e63", "seminar_id": 880, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "881": {"seminar_date": "Wed, May 6, 2020", "seminar_time": "12:00", "timezone": "America/New_York", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/katherine-nagel-world", "password": "", "video_on_demand": "", "speaker_title": "Dr", "seminar_speaker": "Katherine Nagel", "speaker_affil": "New York University", "speaker_twitter": "", "speaker_website": "http://www.nagellab.com/", "topic_tags": "invertebrate, behaviour", "seminar_title": "Algorithms and circuits for olfactory navigation in walking Drosophila", "seminar_abstract": "Olfactory navigation provides a tractable model for studying the circuit basis of sensori-motor transformations and goal-directed behaviour.  Macroscopic organisms typically navigate in odor plumes that provide a noisy and uncertain signal about the location of an odor source.  Work in many species has suggested that animals accomplish this task by combining temporal processing of dynamic odor information with an estimate of wind direction.\nOur lab has been using adult walking Drosophila to understand both the computational algorithms and the neural circuits that support navigation in a plume of attractive food odor.  We developed a high-throughput paradigm to study behavioural responses to temporally-controlled odor and wind stimuli.  Using this paradigm we found that flies respond to a food odor (apple cider vinegar) with two behaviours: during the odor they run upwind, while after odor loss they perform a local search.  A simple computational model based one these two responses is sufficient to replicate many aspects of fly behaviour in a natural turbulent plume. \nIn on-going work, we are seeking to identify the neural circuits and biophysical mechanisms that perform the computations delineated by our model.  Using electrophysiology, we have identified mechanosensory neurons that compute wind direction from movements of the two antennae and central mechanosensory neurons that encode wind direction are are involved in generating a stable downwind orientation.  Using optogenetic activation, we have traced olfactory circuits capable of evoking upwind orientation and offset search from the periphery, through the mushroom body and lateral horn, to the central complex.  Finally, we have used optogenetic activation, in combination with molecular manipulation of specific synapses, to localize temporal computations performed on the odor signal to olfactory transduction and transmission at specific synapses.  Our work illustrates how the tools available in fruit fly can be applied to dissect the mechanisms underlying a complex goal-directed behaviour.", "hosted_by": "Systems Neuroecology", "domain": ["Neuroscience"], "calendar_event_hash": "f0e568075a86a2e14dfddedca088e41bf67a72df6065d49301c0556b4d8cbe09", "seminar_id": 881, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "882": {"seminar_date": "Wed, May 13, 2020", "seminar_time": "12:00", "timezone": "America/New_York", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/john-tuthill-world-wide", "password": "", "video_on_demand": "", "speaker_title": "Dr", "seminar_speaker": "John Tuthill", "speaker_affil": "University of Washington", "speaker_twitter": "@casa_tuthill", "speaker_website": "https://faculty.washington.edu/tuthill/index.html", "topic_tags": "invertebrate", "seminar_title": "Neural mechanisms of proprioception and motor control in Drosophila", "seminar_abstract": "Animals rely on an internal sense of body position and movement to effectively control motor behaviour. This sense of proprioception is mediated by diverse populations of internal mechanosensory neurons distributed throughout the body.\n   My lab is trying to understand how proprioceptive stimuli are detected by sensory neurons, integrated and transformed in central circuits, and used to guide motor output. We approach these questions using genetic tools, in vivo two-photon imaging, and patch-clamp electrophysiology in Drosophila. We recently found that the axons of fly leg proprioceptors are organized into distinct functional projections that contain topographic representations of specific kinematic features: one group of axons encodes tibia position, another encodes movement direction, and a third encodes bidirectional movement and vibration frequency. Whole-cell recordings from downstream neurons reveal that position, movement, and directional information remain segregated in central circuits. These feedback signals then converge upon motor neurons that control leg muscles during walking.\n   Overall, our findings reveal how a low-dimensional stimulus \u2013 the angle of a single leg joint \u2013 is encoded by a diverse population of mechanosensory neurons. Specific proprioceptive parameters are initially processed by parallel pathways, but are ultimately integrated to influence motor output. This architecture may help to maximize information transmission, processing speed, and robustness, which are critical for feedback control of the limbs during adaptive locomotion.", "hosted_by": "Systems Neuroecology", "domain": ["Neuroscience"], "calendar_event_hash": "e65065e312542d3b128f51fc34801286ec2063cbd69175633c416e2918bbdaf8", "seminar_id": 882, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "883": {"seminar_date": "Wed, May 20, 2020", "seminar_time": "12:00", "timezone": "America/New_York", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/michael-reiser-world", "password": "", "video_on_demand": "https://www.crowdcast.io/e/michael-reiser-world", "speaker_title": "Dr", "seminar_speaker": "Michael Reiser", "speaker_affil": "Janelia Research Campus", "speaker_twitter": "@MichaelBReiser", "speaker_website": "https://www.janelia.org/lab/reiser-lab", "topic_tags": "vision, invertebrate, drosophila", "seminar_title": "Motion vision in Drosophila: from single neuron computation to behaviour", "seminar_abstract": "How nervous systems control behaviour is the main question we seek to answer in neuroscience. Although visual systems have been a popular entry point into the brain, we don\u2019t understand\u2014in any deep sense\u2014how visual perception guides navigation in flies (or any organism). I will present recent progress towards this goal from our lab. We are using  anatomical insights from connectomics, genetic methods for labelling and manipulating identified cell types, neurophysiology, behaviour, and computational modeling to explain how the fly brain processes visual motion to regulate behaviour.", "hosted_by": "Systems Neuroecology", "domain": ["Neuroscience"], "calendar_event_hash": "5e920a7811d1b2f8328380538e730281e607ab9fd1518b3afcb8fbebe26992c5", "seminar_id": 883, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "884": {"seminar_date": "Wed, May 27, 2020", "seminar_time": "12:00", "timezone": "America/New_York", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/deborah-gordon-world", "password": "", "video_on_demand": "", "speaker_title": "Dr", "seminar_speaker": "Deborah Gordon", "speaker_affil": "Stanford University", "speaker_twitter": "", "speaker_website": "https://web.stanford.edu/~dmgordon/", "topic_tags": "invertebrate", "seminar_title": "The ecology of collective behaviour", "seminar_abstract": "Collective behaviour operates without central control, through interactions among individuals. The collective behaviour of ant colonies is based on simple olfactory interactions. Ant species differ enormously in the algorithms that regulate collective behaviour, reflecting diversity in ecology.  I will contrast two species in very different ecological situations. Harvester ant colonies in the desert, where water is scarce but conditions are stable, regulate foraging to conserve water.  Response to positive feedback from olfactory interactions depends on the risk of water loss, mediated by dopamine neurophysiology. For arboreal turtle ants in the tropical forest, life is easy but unpredictable, and a highly modular system uses negative feedback to sustain activity. In all natural systems, from ant colonies to brains, collective behaviour evolves in relation with changing conditions. Similar dynamics in environmental conditions may lead to the evolution of similar processes to regulate collective behaviour.", "hosted_by": "Systems Neuroecology", "domain": ["Neuroscience"], "calendar_event_hash": "3469543e030d3aea4e95d95372ac8e11c778d9034c7701b049cc6afb95b028c5", "seminar_id": 884, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "885": {"seminar_date": "Wed, Jun 17, 2020", "seminar_time": "12:00", "timezone": "America/New_York", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/natasha-mhatres-world", "password": "", "video_on_demand": "https://www.crowdcast.io/e/natasha-mhatres-world", "speaker_title": "Dr", "seminar_speaker": "Natasha Mhatre", "speaker_affil": "University of Western Ontario", "speaker_twitter": "@NatashaMhatre", "speaker_website": "https://www.natashamhatre.net/", "topic_tags": "invertebrate", "seminar_title": "The active modulation of sound and vibration perception", "seminar_abstract": "The dominant view of perception right now is that information travels from the environment to the sensory system, then to the nervous systems which processes it to generate a percept and behaviour. Ongoing behaviour is thought to occur largely through simple iterations of this process. However, this linear view, where information flows only in one direction and the properties of the environment and the sensory system remain static and unaffected by behaviour, is slowly fading. Many of us are beginning to appreciate that perception is largely active, i.e. that information flows back and forth between the three systems modulating their respective properties. In other words, in the real world, the environment and sensorimotor loop is pretty much always closed. I study the loop; in particular I study how the reverse arm of the loop affects sound and vibration perception.\nI will present two examples of motor modulation of perception at two very different temporal and spatial scales. First, in crickets, I will present data on how high-speed molecular motor activity enhances hearing via the well-studied phenomenon of active amplification. Second, in spiders I will present data on how body posture, a slow macroscopic feature, which can barely be called \u2018active\u2019, can nonetheless modulate vibration perception. I hope these results will motivate a conversation about whether \u2018active\u2019 perception is an optional feature observed in some sensory systems, or something that is ultimately necessitated by both evolution and physics.", "hosted_by": "Systems Neuroecology", "domain": ["Neuroscience"], "calendar_event_hash": "7e54f76479d6d8374bb276c973b8f2bc8853ca4153548db10521688618ca6b4d", "seminar_id": 885, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "886": {"seminar_date": "Wed, Jun 24, 2020", "seminar_time": "12:00", "timezone": "America/New_York", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/benjamin-de-bivort-world", "password": "", "video_on_demand": "https://www.crowdcast.io/e/benjamin-de-bivort-world", "speaker_title": "Dr", "seminar_speaker": "Benjamin de Bivort", "speaker_affil": "Harvard University", "speaker_twitter": "@debivort", "speaker_website": "", "topic_tags": "invertebrate", "seminar_title": "Functional and structural loci of individuality in the Drosophila olfactory circuit", "seminar_abstract": "behaviour varies even among genetically identical animals raised in the same environment. However, little is known about the circuit or anatomical underpinnings of this individuality, though previous work implicates sensory periphery. Drosophila olfaction presents an ideal model to study the biological basis of behavioural individuality, because while the neural circuit underlying olfactory behaviour is well-described and highly stereotyped, persistent idiosyncrasy in behaviour, neural coding, and neural wiring have also been described. Projection neurons (PNs), which relay odor signals sensed by olfactory receptor neurons (ORNs) to deeper brain structures, exhibit variable calcium responses to identical odor stimuli across individuals, but how these idiosyncrasies relate to individual behavioural responses remains unknown. Here, using paired behaviour and two-photon imaging measurements, we show that idiosyncratic calcium dynamics in both ORNs and PNs predict individual preferences for an aversive monomolecular odorant versus air, suggesting that variation at the periphery of the olfactory system determines individual preference for an odor\u2019s presence. In contrast, PN, but not ORN, calcium responses predict individual preferences in a two-odor choice assay. Furthermore, paired behaviour and immunohistochemistry measurements reveal that variation in ORN presynaptic density also predicts two-odor preference, suggesting this site is a locus of individuality where microscale circuit variation gives rise to idiosyncrasy in behaviour. Our results demonstrate how a neural circuit may vary functionally and structurally to produce variable behaviour among individuals.", "hosted_by": "Systems Neuroecology", "domain": ["Neuroscience"], "calendar_event_hash": "ef5f6392f9122f9d1ba406328276a893dd3352a6482ad2a043d606400d112663", "seminar_id": 886, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "887": {"seminar_date": "Wed, Jul 1, 2020", "seminar_time": "12:00", "timezone": "America/New_York", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/vanessa-ruta-world-wide", "password": "", "video_on_demand": "https://www.crowdcast.io/e/vanessa-ruta-world-wide", "speaker_title": "Dr", "seminar_speaker": "Vanessa Ruta", "speaker_affil": "Rockefeller University", "speaker_twitter": "", "speaker_website": "https://www.rockefeller.edu/our-scientists/heads-of-laboratories/989-vanessa-ruta/", "topic_tags": "invertebrate", "seminar_title": "Theme and variations: circuit mechanisms of behavioural evolution", "seminar_abstract": "Animals exhibit extraordinary variation in their behaviour, yet little is known about the neural mechanisms that generate this diversity. My lab has been taking advantage of the rapid diversification of male courtship behaviours in Drosophila to gain insight into how evolution shapes the nervous system to generate species-specific behaviours. By translating neurogenetic tools from D. melanogaster to closely related Drosophila species, we have begun to directly compare the homologous neural circuits and pinpoint sites of adaptive change. Across species, P1 interneurons serve as a conserved and key node in regulating male courtship: these neurons are selectively activated by the sensory cues carried by an appropriate mate and their activation triggers enduring courtship displays. We have been examining how different sensory pathways converge onto P1 neurons to regulate a male\u2019s state of arousal, honing his pursuit of a prospective partner.  Moreover, by performing cross-species comparison of these circuits, we have begun to gain insight into how reweighting of sensory inputs to P1 neurons underlies species-specific mate recognition.  Our results suggest how variation at flexible nodes within the nervous system can serve as a substrate for behavioural evolution, shedding light on the types of changes that are possible and preferable within brain circuits.", "hosted_by": "Systems Neuroecology", "domain": ["Neuroscience"], "calendar_event_hash": "c1a373b542d57744edaab3ba36c1c7b8799fffc2eb10761e5549fd1faca2c442", "seminar_id": 887, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "888": {"seminar_date": "Wed, Jul 8, 2020", "seminar_time": "12:00", "timezone": "America/New_York", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/andrew-gordus-world-wide", "password": "", "video_on_demand": "https://www.crowdcast.io/e/andrew-gordus-world-wide", "speaker_title": "Dr", "seminar_speaker": "Andrew Gordus", "speaker_affil": "John Hopkins University", "speaker_twitter": "@elegansdiversus", "speaker_website": "https://gorduslab.bio.jhu.edu/", "topic_tags": "invertebrate", "seminar_title": "Untangling the web of behaviours used to produce spider orb webs", "seminar_abstract": "Many innate behaviours are the result of multiple sensorimotor programs that are dynamically coordinated to produce higher-order behaviours such as courtship or architecture construction. Extendend phenotypes such as architecture are especially useful for ethological study because the structure itself is a physical record of behavioural intent. A particularly elegant and easily quantifiable structure is the spider orb-web. The geometric symmetry and regularity of these webs have long generated interest in their behavioural origin. However, quantitative analyses of this behaviour have been sparse due to the difficulty of recording web-making in real-time. To address this, we have developed a novel assay enabling real-time, high-resolution tracking of limb movements and web structure produced by the hackled orb-weaver Uloborus diversus. With its small brain size of approximately 100,000 neurons, the spider U. diversus offers a tractable model organism for the study of complex behaviours. Using deep learning frameworks for limb tracking, and unsupervised behavioural clustering methods, we have developed an atlas of stereotyped movement motifs and are investigating the behavioural state transitions of which the geometry of the web is an emergent property. In addition to tracking limb movements, we have developed algorithms to track the web\u2019s dynamic graph structure. We aim to model the relationship between the spider\u2019s sensory experience on the web and its motor decisions, thereby identifying the sensory and internal states contributing to this sensorimotor transformation. Parallel efforts in our group are establishing 2-photon in vivo calcium imaging protocols in this spider, eventually facilitating a search for neural correlates underlying the internal and sensory state variables identified by our behavioural models. In addition, we have assembled a genome, and are developing genetic perturbation methods to investigate the genetic underpinnings of orb-weaving behaviour. Together, we aim to understand how complex innate behaviours are coordinated by underlying neuronal and genetic mechanisms.", "hosted_by": "Systems Neuroecology", "domain": ["Neuroscience"], "calendar_event_hash": "f84ffadf2f1af13759d25c08156ad031b0d4b21749234920c0055f8790c36ef6", "seminar_id": 888, "time_of_addition": "Mon, Sep 28, 2020 11:07"}, "520": {"seminar_date": "Wed, Jul 22, 2020", "seminar_time": "12:00", "timezone": "America/New_York", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/lindy-mcbride", "password": "", "video_on_demand": "https://www.crowdcast.io/e/lindy-mcbride", "speaker_title": "Dr", "seminar_speaker": "Lindy McBride", "speaker_affil": "Princeton University", "speaker_twitter": "@lindymcbr", "speaker_website": "https://mcbridelab.princeton.edu/", "topic_tags": "invertebrate, human", "seminar_title": "A robust neural code for human odor in the Aedes aegpyti mosquito brain", "seminar_abstract": "A globally invasive form of the mosquito Aedes aegypti has evolved to specialize in biting humans, making it an efficient vector of dengue, yellow fever, Zika, and chikungunya. Host-seeking females identify humans primarily by smell, strongly preferring human odour over the odor of non-human animals. Exactly how they discriminate, however, is unclear. Human and animal odors are complex blends that share most of the same chemical components, presenting an interesting challenge in sensory coding. I will talk about recent work from the lab showing that (1) human and animal blends can be distinguished by the relative concentration of a diverse array of compounds and that (2) these complex chemical differences translate into a neural code for human odor that involves as few as two to three olfactory glomeruli in the mosquito brain. Our work demonstrates how organisms may evolve to discriminate complex odor stimuli of special biological relevance with a surprisingly simple combinatorial code and reveals novel targets for the design of next-generation mosquito control strategies.", "hosted_by": "Systems Neuroecology", "domain": ["Neuroscience"], "calendar_event_hash": "b69435af20ac399354739a4a315a0b9613941fbef2f0af71f09905d85e1845d4", "seminar_id": 520, "time_of_addition": "Tue, Aug 25, 2020 03:40"}, "521": {"seminar_date": "Wed, Jul 29, 2020", "seminar_time": "12:00", "timezone": "America/New_York", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/piali-sengupta", "password": "", "video_on_demand": "https://www.crowdcast.io/e/piali-sengupta", "speaker_title": "Dr", "seminar_speaker": "Piali Sengupta", "speaker_affil": "Brandeis University", "speaker_twitter": "@SenguptaLab", "speaker_website": "https://www.senguptalab.org/", "topic_tags": "invertebrate, c elegas", "seminar_title": "Food Mind Control: Regulation of Sensory Behaviors by Gut-Brain Signaling", "seminar_abstract": "How does the presence or absence of food shape and prioritize behavioral decisions? When is food more than just food? As in other animals, prolonged food deprivation dramatically alters sensory behaviors in C. elegans. For instance, it has been known since the mid-1970s that hungry worms no longer respond to temperature changes in their environment, but the underlying mechanisms have been unclear. I will describe unpublished work showing that insulin signaling from the gut regulates thermosensory behaviors as a function of feeding state by engaging a modulatory sensorimotor circuit that gates the output of the core thermosensory network. C. elegans is associated with, and consumes, diverse bacteria in the wild. I will also discuss a recent story in which we find that in addition to providing nutrition, a bacterial strain in the worm gut alters the hosts\u2019 olfactory behavior and drives food choice decisions by producing a neurotransmitter that targets the hosts\u2019 sensory neurons. These results add to our growing body of knowledge of how signaling from the gut modulates peripheral and central neuron properties and drives sensory behavioral plasticity.", "hosted_by": "Systems Neuroecology", "domain": ["Neuroscience"], "calendar_event_hash": "77537e826262ce10db863a62a57dc0b9558899aea5556cabbdba640f93053738", "seminar_id": 521, "time_of_addition": "Tue, Aug 25, 2020 03:40"}, "1116": {"seminar_date": "Wed, Oct 7, 2020", "seminar_time": "12:00", "timezone": "America/New_York", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/adrienne-fairhall", "password": "", "video_on_demand": "", "speaker_title": "Dr", "seminar_speaker": "Adrienne Fairhall", "speaker_affil": "University of Washington", "speaker_twitter": "@alfairhall", "speaker_website": "https://fairhalllab.com/", "topic_tags": "hydra", "seminar_title": "Reverse engineering neural control of movement in Hydra", "seminar_abstract": "Hydra is a fascinating model organism for neuroscience. It is transparent; new genetic lines allow one to image activity in both neurons (Dupre and Yuste, 2017) and muscle cells (Szymanski and Yuste, 2019) ; it exhibits rich behavior, and it continually rebuilds itself. Hydra\u2019s fairly simply physical structure as a two-layered fluid-filled hydrostat and the accessibility of information about neural and muscle activity opens the possibility of a complete model of neural control of behavior. This requires understanding the transformations that occur in the muscle cell layers and a biomechanical model of the body column. We show that we can use this modeling to reverse engineer how neural activity drives behavior.", "hosted_by": "Systems Neuroecology", "domain": ["Neuroscience"], "calendar_event_hash": "b5d2cb762855019f93ce2d1702e90915664b54bcab5f35488c713a694e996b81", "seminar_id": 1116, "time_of_addition": "Mon, Oct 05, 2020 12:06"}, "1117": {"seminar_date": "Wed, Oct 21, 2020", "seminar_time": "12:00", "timezone": "America/New_York", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/julia-fischer-systems", "password": "", "video_on_demand": "", "speaker_title": "Dr", "seminar_speaker": "Julia Fischer", "speaker_affil": "Deutsche Primate Center", "speaker_twitter": "@julxf", "speaker_website": "https://www.dpz.eu/en/unit/cognitive-ethology/about-us.html", "topic_tags": "speech, vocalizations, sensory-motor integration", "seminar_title": "Monkey Talk \u2013 what studies about nonhuman primate vocal communication reveal about the evolution of speech", "seminar_abstract": "The evolution of speech is considered to be one of the hardest problems in science. Studies of the communicative abilities of our closest living relatives, the nonhuman primates, aim to contribute to a better understanding of the emergence of this uniquely human capability. Following a brief introduction over the key building blocks that make up the human speech faculty, I will focus on the question of meaning in nonhuman primate vocalizations. While nonhuman primate calls may be highly context specific, thus giving rise to the notion of \u2018referentiality\u2019, comparisons across closely related species suggest that this specificity is evolved rather than learned. Yet, as in humans, the structure of calls varies with arousal and affective state, and there is some evidence for effects of sensory-motor integration in vocal production. Thus, the vocal production of nonhuman primates bears little resemblance to the symbolic and combinatorial features of human speech, while basic production mechanisms are shared. Listeners, in contrast, are able learning the meaning of new sounds. A recent study using artificial predator shows that this learning may be extremely rapid. Furthermore, listeners are able to integrate information from multiple sources to make adaptive decisions, which renders the vocal communication system as a whole relatively flexible and powerful. In conclusion, constraints at the side of vocal production, including limits in social cognition and motivation to share experiences, rather than constraints at the side of the recipient explain the differences in communicative abilities between humans and other animals.", "hosted_by": "Systems Neuroecology", "domain": ["Neuroscience"], "calendar_event_hash": "cc08c155eb32dfb081df0595d0de4ee43b4d229165a1deeb5e75b75d5b3bb6c7", "seminar_id": 1117, "time_of_addition": "Mon, Oct 05, 2020 12:06"}, "1118": {"seminar_date": "Wed, Nov 4, 2020", "seminar_time": "12:00", "timezone": "America/New_York", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/eugenia-chiappe-systems", "password": "", "video_on_demand": "", "speaker_title": "Dr", "seminar_speaker": "Eugenia Chiappe", "speaker_affil": "Champalimaud Center for the Unknown", "speaker_twitter": "@EugeChapadur", "speaker_website": "https://chiappelab.org/", "topic_tags": "", "seminar_title": "TBD", "seminar_abstract": "TBD", "hosted_by": "Systems Neuroecology", "domain": ["Neuroscience"], "calendar_event_hash": "79db4a8ca50a87f45d35ec402404820db511e864d7d8e772e27568b99fcc2462", "seminar_id": 1118, "time_of_addition": "Mon, Oct 05, 2020 12:06"}, "1119": {"seminar_date": "Wed, Nov 25, 2020", "seminar_time": "12:00", "timezone": "America/New_York", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/yossi-yovel-systems", "password": "", "video_on_demand": "", "speaker_title": "Dr", "seminar_speaker": "Yossi Yovel", "speaker_affil": "Tel Aviv University", "speaker_twitter": "", "speaker_website": "http://www.yossiyovel.com/", "topic_tags": "spatial navigation, reinforcement learning, bats", "seminar_title": "On cognitive maps and reinforcement learning in large-scale animal behaviour", "seminar_abstract": "Bats are extreme aviators and amazing navigators. Many bat species nightly com-mute dozens of kilometres in search of food, and some bat species annually migrate over thousands of kilometres. Studying bats in their natural environment has al-ways been extremely challenging because of their small size (mostly <50 gr) and agile nature. We have recently developed novel miniature technology allowing us to GPS-tag small bats, thus opening a new window to document their behaviour in the wild. We have used this technology to track fruit-bats pups over 5 months from birth to adulthood. Following the bats\u2019 full movement history allowed us to show that they use novel short-cuts which are typical for cognitive-map based naviga-tion. In a second study, we examined how nectar-feeding bats make foraging deci-sions under competition. We show that by relying on a simple reinforcement learn-ing strategy, the bats can divide the resource between them without aggression or communication. Together, these results demonstrate the power of the large scale natural approach for studying animal behavior.", "hosted_by": "Systems Neuroecology", "domain": ["Neuroscience"], "calendar_event_hash": "e65ddfce28687e2996006df3f8e4d646f4493a98ca306b7afc0ecf76558d343a", "seminar_id": 1119, "time_of_addition": "Mon, Oct 05, 2020 12:06"}, "1120": {"seminar_date": "Wed, Dec 2, 2020", "seminar_time": "12:00", "timezone": "America/New_York", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/dayu-lin-systems", "password": "", "video_on_demand": "", "speaker_title": "Dr", "seminar_speaker": "Dayu Lin", "speaker_affil": "NYU", "speaker_twitter": "@moccalin", "speaker_website": "http://linlab.med.nyu.edu/", "topic_tags": "", "seminar_title": "Neural mechanisms of aggression", "seminar_abstract": "Aggression is an innate social behavior essential for competing for resources, securing mates, defending territory and protecting the safety of oneself and family. In the last decade, significant progress has been made towards an understanding of the neural circuit underlying aggression using a set of modern neuroscience tools. Here, I will talk about the history and recent progress in the study of aggression.", "hosted_by": "Systems Neuroecology", "domain": ["Neuroscience"], "calendar_event_hash": "0314b978ae1041ad00802d82340a30f3db7101b89f6fdeb2ee8b4d00e2895c4d", "seminar_id": 1120, "time_of_addition": "Mon, Oct 05, 2020 12:06"}, "1121": {"seminar_date": "Wed, Dec 16, 2020", "seminar_time": "12:00", "timezone": "America/New_York", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/melissa-coleman-systems", "password": "", "video_on_demand": "", "speaker_title": "Dr", "seminar_speaker": "Melissa Coleman", "speaker_affil": "Claremont McKenna", "speaker_twitter": "@MelColemanLab", "speaker_website": "https://www.kecksci.claremont.edu/faculty/profile.asp?FacultyID=179", "topic_tags": "", "seminar_title": "Neural Mechanisms of Coordination in Duetting Wrens", "seminar_abstract": "To communicate effectively, two individuals must take turns to prevent overlap in their signals. How does the nervous system coordinate vocalizations between two individuals? Female and male plain-tailed wrens sing a duet in which they alternate syllable production so rapidly and precisely it sounds as if a single bird is singing. I will talk about experiments that examine the interaction between sensory cues and motor activity, using behavioral manipulations and neurophysiological recordings from pairs of awake, duetting wrens. I will show evidence that auditory cues link the brains of the wrens by modulating motor circuits.", "hosted_by": "Systems Neuroecology", "domain": ["Neuroscience"], "calendar_event_hash": "f44c950ffd61f133fed5a0e9e7e128a0f454356b7cf0e4062b5499953a3be3a3", "seminar_id": 1121, "time_of_addition": "Mon, Oct 05, 2020 12:06"}, "1122": {"seminar_date": "Wed, Jan 13, 2021", "seminar_time": "12:00", "timezone": "America/New_York", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/orit-peleg-systems", "password": "", "video_on_demand": "", "speaker_title": "Dr", "seminar_speaker": "Orit Peleg", "speaker_affil": "CU Boulder", "speaker_twitter": "@oritpeleg", "speaker_website": "https://www.peleglab.com/", "topic_tags": "", "seminar_title": "Collective Ecophysiology and Physics of Social Insects", "seminar_abstract": "Collective behavior of organisms creates environmental micro-niches that buffer them from environmental fluctuations e.g., temperature, humidity, mechanical perturbations, etc., thus coupling organismal physiology, environmental physics, and population ecology. This talk will focus on a combination of biological experiments, theory, and computation to understand how a collective of bees can integrate physical and behavioral cues to attain a non-equilibrium steady state that allows them to resist and respond to environmental fluctuations of forces and flows. We analyze how bee clusters change their shape and connectivity and gain stability by spread-eagling themselves in response to mechanical perturbations. Similarly, we study how bees in a colony respond to environmental thermal perturbations by deploying a fanning strategy at the entrance that they use to create a forced ventilation stream that allows the bees to collectively maintain a constant hive temperature. When combined with quantitative analysis and computations in both systems, we integrate the sensing of the environmental cues (acceleration, temperature, flow) and convert them to behavioral outputs that allow the swarms to achieve a dynamic homeostasis.", "hosted_by": "Systems Neuroecology", "domain": ["Neuroscience"], "calendar_event_hash": "cbb8475cc591296fdc13a8b18f660932adbd07424a99a71f60106f08c49c03eb", "seminar_id": 1122, "time_of_addition": "Mon, Oct 05, 2020 12:06"}, "1123": {"seminar_date": "Wed, Jan 20, 2021", "seminar_time": "12:00", "timezone": "America/New_York", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/amy-toth-systems", "password": "", "video_on_demand": "", "speaker_title": "Dr", "seminar_speaker": "Amy Toth", "speaker_affil": "Iowa State University", "speaker_twitter": "@Amy_L_Toth", "speaker_website": "https://www.tothlab.org/", "topic_tags": "", "seminar_title": "Integrative genomics of paper wasp behavior: Molecular underpinnings of complex traits and insights into social evolution", "seminar_abstract": "", "hosted_by": "Systems Neuroecology", "domain": ["Neuroscience"], "calendar_event_hash": "11d3d6e2b62fdae50b16b7e1dc105f4237b32ef5b3f2809aef3913b7ee251da8", "seminar_id": 1123, "time_of_addition": "Mon, Oct 05, 2020 12:06"}, "1124": {"seminar_date": "Wed, Feb 3, 2021", "seminar_time": "12:00", "timezone": "America/New_York", "posted": "yes", "seminar_link": "https://www.crowdcast.io/e/vivek-nityananda-systems", "password": "", "video_on_demand": "", "speaker_title": "Dr", "seminar_speaker": "Vivek Nityananda", "speaker_affil": "Newcastle U", "speaker_twitter": "@VivekNityananda", "speaker_website": "viveknityananda.com", "topic_tags": "", "seminar_title": "Stereo vision and prey detection in the praying mantis", "seminar_abstract": "Praying mantises are the only insects known to have stereo vision. We used a comparative approach to determine how the mechanisms underlying stereopsis in mantises differ from those underlying primate stereo vision. By testing mantises with virtual 3D targets we showed that mantis stereopsis enables prey capture in complex scenes but the mechanisms underlying it differ from those underlying primate stereopsis. My talk will further discuss how stereopsis combines with second-order motion perception to enable the detection of camouflaged prey by mantises. The talk will highlight the benefits of a comparative approach towards understanding visual cognition.", "hosted_by": "Systems Neuroecology", "domain": ["Neuroscience"], "calendar_event_hash": "e825b1a60603037beb6764ef48e9b7ec8bf331650ddcb25e4abcc1528aa087e6", "seminar_id": 1124, "time_of_addition": "Mon, Oct 05, 2020 12:06"}, "1125": {"seminar_date": "Wed, Feb 17, 2021", "seminar_time": "12:00", "timezone": "America/New_York", "posted": "yes", "seminar_link": "", "password": "", "video_on_demand": "", "speaker_title": "Dr", "seminar_speaker": "Ben Hayden", "speaker_affil": "University of Minnesota", "speaker_twitter": "", "speaker_website": "https://www.haydenlab.com/", "topic_tags": "", "seminar_title": "", "seminar_abstract": "", "hosted_by": "Systems Neuroecology", "domain": ["Neuroscience"], "calendar_event_hash": "ef8d6075c6dc648d5821fbbf6ec3a5d26a3e9f35ccd0eaa9d0eaf9cb3b05935d", "seminar_id": 1125, "time_of_addition": "Mon, Oct 05, 2020 12:06"}}