diff --git a/botocore/utils.py b/botocore/utils.py
index 314d30516d..a54f4a39d3 100644
--- a/botocore/utils.py
+++ b/botocore/utils.py
@@ -1776,6 +1776,10 @@ def redirect_from_error(self, request_dict, response, operation, **kwargs):
             0
         ].status_code in (301, 302, 307)
         is_permanent_redirect = error_code == 'PermanentRedirect'
+        is_opt_in_region_redirect = (
+            error_code == 'IllegalLocationConstraintException'
+            and operation.name != 'CreateBucket'
+        )
         if not any(
             [
                 is_special_head_object,
@@ -1783,6 +1787,7 @@ def redirect_from_error(self, request_dict, response, operation, **kwargs):
                 is_permanent_redirect,
                 is_special_head_bucket,
                 is_redirect_status,
+                is_opt_in_region_redirect,
             ]
         ):
             return
diff --git a/tests/unit/test_utils.py b/tests/unit/test_utils.py
index 8a92bd6b06..6143183418 100644
--- a/tests/unit/test_utils.py
+++ b/tests/unit/test_utils.py
@@ -1879,6 +1879,66 @@ def test_does_not_redirect_if_None_response(self):
         )
         self.assertIsNone(redirect_response)
 
+    def test_redirects_on_illegal_location_constraint_from_opt_in_region(self):
+        request_dict = {
+            'url': 'https://il-central-1.amazonaws.com/foo',
+            'context': {
+                's3_redirect': {
+                    'bucket': 'foo',
+                    'redirected': False,
+                    'params': {'Bucket': 'foo'},
+                },
+                'signing': {},
+            },
+        }
+        response = (
+            None,
+            {
+                'Error': {'Code': 'IllegalLocationConstraintException'},
+                'ResponseMetadata': {
+                    'HTTPHeaders': {'x-amz-bucket-region': 'eu-central-1'}
+                },
+            },
+        )
+
+        self.operation.name = 'GetObject'
+        redirect_response = self.redirector.redirect_from_error(
+            request_dict, response, self.operation
+        )
+        self.assertEqual(redirect_response, 0)
+
+    def test_no_redirect_on_illegal_location_constraint_from_bad_location_constraint(
+        self,
+    ):
+        request_dict = {
+            'url': 'https://us-west-2.amazonaws.com/foo',
+            'context': {
+                's3_redirect': {
+                    'bucket': 'foo',
+                    'redirected': False,
+                    'params': {
+                        'Bucket': 'foo',
+                        'CreateBucketConfiguration': {
+                            'LocationConstraint': 'eu-west-2',
+                        },
+                    },
+                },
+                'signing': {},
+            },
+        }
+        response = (
+            None,
+            {
+                'Error': {'Code': 'IllegalLocationConstraintException'},
+            },
+        )
+
+        self.operation.name = 'CreateBucket'
+        redirect_response = self.redirector.redirect_from_error(
+            request_dict, response, self.operation
+        )
+        self.assertIsNone(redirect_response)
+
     def test_get_region_from_response(self):
         response = (
             None,