diff --git a/requirements.txt b/requirements.txt
index 2c59392..cdb3b13 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -1,5 +1,5 @@
 numexpr==2.6.9
-numpy==1.16.6
+numpy==1.16.4
 pysam==0.15.2
 PyYAML==5.4
 scikit-learn==0.20.3
diff --git a/setup.py b/setup.py
index 29121af..da4c6c4 100644
--- a/setup.py
+++ b/setup.py
@@ -42,7 +42,7 @@ def read(infile):
     include_package_data=True,
     zip_safe=False,
     install_requires=[
-        'argparse>=1.2.1', 'PyYAML==5.4', 'pysam==0.15.2', 'numpy==1.16.6',
+        'argparse>=1.2.1', 'PyYAML==5.4', 'pysam==0.15.2', 'numpy==1.16.4',
         'scipy==1.2.2', 'scikit-learn==0.20.3', 'numexpr==2.6.9',
     ],
 )