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Can the RNA velo calculated by Dynamo combined with PAGA? #710

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billqiao1991 opened this issue Dec 7, 2024 · 1 comment
Open

Can the RNA velo calculated by Dynamo combined with PAGA? #710

billqiao1991 opened this issue Dec 7, 2024 · 1 comment
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@billqiao1991
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scvelo can use sc.tl.paga(adata, groups='celltype', use_rna_velocity=True) to combine the results with PAGA, can Dynamo combine with PAGA?

@billqiao1991 billqiao1991 added the help wanted Extra attention is needed label Dec 7, 2024
@Sichao25
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Sichao25 commented Dec 25, 2024

Hi, thanks for raising this discussion. Dynamo doesn’t have an exact equivalent to PAGA, but it does offer similar features, such as the cell type transition graph in dyn.pd.state_graph() or the minimum spanning tree in dyn.tl.order_cells()/dyn.tl.DDRTree(). Additionally, you can combine Dynamo with scanpy/scvelo since they share a similar data structure. Let me know if this helps!

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