diff --git a/include/clad/Differentiator/Differentiator.h b/include/clad/Differentiator/Differentiator.h
index cca1cd5cf..4710e3d00 100644
--- a/include/clad/Differentiator/Differentiator.h
+++ b/include/clad/Differentiator/Differentiator.h
@@ -577,9 +577,11 @@ CUDA_HOST_DEVICE T push(tape<T>& to, ArgsT... val) {
                        code);
   }
 
+#ifdef CLAD_ENABLE_ENZYME_BACKEND
   // Gradient Structure for Reverse Mode Enzyme
   template <unsigned N> struct EnzymeGradient { double d_arr[N]; };
   } // namespace clad
+#endif
 #endif // CLAD_DIFFERENTIATOR
 
 // Enable clad after the header was included.
diff --git a/include/clad/Differentiator/ReverseModeVisitor.h b/include/clad/Differentiator/ReverseModeVisitor.h
index ad9981bb1..05935f50f 100644
--- a/include/clad/Differentiator/ReverseModeVisitor.h
+++ b/include/clad/Differentiator/ReverseModeVisitor.h
@@ -95,8 +95,10 @@ namespace clad {
     // Function to Differentiate with Clad as Backend
     void DifferentiateWithClad();
 
+#ifdef CLAD_ENABLE_ENZYME_BACKEND
     // Function to Differentiate with Enzyme as Backend
     void DifferentiateWithEnzyme();
+#endif
 
     /// Tries to find and build call to user-provided `_forw` function.
     clang::Expr* BuildCallToCustomForwPassFn(
diff --git a/lib/Differentiator/ReverseModeVisitor.cpp b/lib/Differentiator/ReverseModeVisitor.cpp
index 4d600caf7..a40584d31 100644
--- a/lib/Differentiator/ReverseModeVisitor.cpp
+++ b/lib/Differentiator/ReverseModeVisitor.cpp
@@ -457,8 +457,10 @@ Expr* getArraySizeExpr(const ArrayType* AT, ASTContext& context,
 
       if (!m_DiffReq.use_enzyme)
         DifferentiateWithClad();
+#ifdef CLAD_ENABLE_ENZYME_BACKEND
       else
         DifferentiateWithEnzyme();
+#endif
 
       gradientBody = endBlock();
       m_Derivative->setBody(gradientBody);
@@ -664,6 +666,7 @@ Expr* getArraySizeExpr(const ArrayType* AT, ASTContext& context,
       m_ExternalSource->ActOnEndOfDerivedFnBody();
   }
 
+#ifdef CLAD_ENABLE_ENZYME_BACKEND
   void ReverseModeVisitor::DifferentiateWithEnzyme() {
     unsigned numParams = m_DiffReq->getNumParams();
     auto origParams = m_DiffReq->parameters();
@@ -772,6 +775,7 @@ Expr* getArraySizeExpr(const ArrayType* AT, ASTContext& context,
       addToCurrentBlock(enzymeCall);
     }
   }
+#endif
 
   StmtDiff ReverseModeVisitor::VisitCXXStdInitializerListExpr(
       const clang::CXXStdInitializerListExpr* ILE) {