diff --git a/src/aiida/orm/nodes/data/singlefile.py b/src/aiida/orm/nodes/data/singlefile.py
index 8faefc8cb4..d4cc4b7095 100644
--- a/src/aiida/orm/nodes/data/singlefile.py
+++ b/src/aiida/orm/nodes/data/singlefile.py
@@ -39,6 +39,17 @@ def from_string(cls, content: str, filename: str | pathlib.Path | None = None, *
         """
         return cls(io.StringIO(content), filename, **kwargs)
 
+    @classmethod
+    def from_bytes(
+        cls, content: bytes, filename: str | pathlib.Path | None = None, **kwargs: t.Any
+    ) -> 'SinglefileData':
+        """Construct a new instance and set ``content`` as its contents.
+
+        :param content: The content as bytes.
+        :param filename: Specify filename to use (defaults to ``file.txt``).
+        """
+        return cls(io.BytesIO(content), filename, **kwargs)
+
     def __init__(
         self, file: str | pathlib.Path | t.IO, filename: str | pathlib.Path | None = None, **kwargs: t.Any
     ) -> None:
diff --git a/tests/orm/nodes/data/test_singlefile.py b/tests/orm/nodes/data/test_singlefile.py
index 304050648a..1d1930d83b 100644
--- a/tests/orm/nodes/data/test_singlefile.py
+++ b/tests/orm/nodes/data/test_singlefile.py
@@ -189,18 +189,40 @@ def test_from_string():
     content = 'some\ncontent'
     node = SinglefileData.from_string(content).store()
     assert node.get_content() == content
+    assert node.get_content('rb') == content.encode()
     assert node.filename == SinglefileData.DEFAULT_FILENAME
 
     content = 'some\ncontent'
     filename = 'custom_filename.dat'
     node = SinglefileData.from_string(content, filename).store()
     assert node.get_content() == content
+    assert node.get_content('rb') == content.encode()
+    assert node.filename == filename
+
+
+def test_from_bytes():
+    """Test the :meth:`aiida.orm.nodes.data.singlefile.SinglefileData.from_bytes` classmethod."""
+    content = b'some\ncontent'
+    node = SinglefileData.from_bytes(content).store()
+    assert node.get_content(mode='rb') == content
+    assert node.get_content(mode='r') == content.decode('utf-8')
+    assert node.filename == SinglefileData.DEFAULT_FILENAME
+
+    content = b'some\ncontent'
+    filename = 'custom_filename.dat'
+    node = SinglefileData.from_bytes(content, filename).store()
+    assert node.get_content(mode='rb') == content
+    assert node.get_content(mode='r') == content.decode('utf-8')
     assert node.filename == filename
 
 
 def test_get_content():
     """Test the :meth:`aiida.orm.nodes.data.singlefile.SinglefileData.get_content` method."""
+    content = 'some\ncontent'
+    node = SinglefileData.from_string(content).store()
+    assert node.get_content() == content
+    assert node.get_content('rb') == content.encode()
     content = b'some\ncontent'
-    node = SinglefileData.from_string(content.decode('utf-8')).store()
+    node = SinglefileData.from_bytes(content).store()
     assert node.get_content() == content.decode('utf-8')
     assert node.get_content('rb') == content