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Add support for multilevel/mixed effects models #62

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marcora opened this issue Apr 2, 2024 · 0 comments
Open

Add support for multilevel/mixed effects models #62

marcora opened this issue Apr 2, 2024 · 0 comments

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@marcora
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marcora commented Apr 2, 2024

The analysis of several experimental designs would benefit from the ability to use multilevel/mixed effects models.

The variancePartition package adds support for multilevel/mixed effects models to limma (under the name of dream) and I am wondering whether it could be added as an option to lipidr.

https://diseaseneurogenomics.github.io/variancePartition/

Hoffman GE, Roussos P (2020). “dream: Powerful differential expression analysis for repeated measures designs.” Bioinformatics. doi:10.1093/bioinformatics/btaa687

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