How to select differential regulons between to conditions in a cell type specific matter

[jeji0209]

Hi, I have a dataset with multiple cell types, and all cells are divided by 2 conditions.
What I want to do is find a condition specific regulons within a certain cell type.
For example, I want to find condition1 specific regulons in cell type B.
I am thinking of three methods currently.

1. compare the AUC activity score of the two cell clusters of my interest using statistic methods such as Wilcoxon test.
   (condition 1, cell type B cells vs. condition 2, cell type B cells)

2. make new cell clusters, considering both condition and cell type. (e.g. cluster1 - cell type A + condition1, cluster2 - cell type A + condition 2, cluster3- cell type B + condition1, cluster4 - cell type B + condition2 , and so on...). Then calculate RSSscores for my newly made clusters.

3. Splitting dataset by condition and running SCENIC seperately, then comparing the results.

Which of the three methods is most appropriate? of any other new ways to suggest?
Thanks in advance :)