Skip to content
New issue

Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.

By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.

Already on GitHub? Sign in to your account

intervertebral ligament ~ mammalian "intervertebral disc" #175

Open
LeylaR opened this issue Feb 1, 2024 · 2 comments
Open

intervertebral ligament ~ mammalian "intervertebral disc" #175

LeylaR opened this issue Feb 1, 2024 · 2 comments
Assignees

Comments

@LeylaR
Copy link

LeylaR commented Feb 1, 2024

Definition of the zebrafish intervertebral ligament from the ZFA: "Ligament that connects adjacent vertebra. The intervertebral ligament (IVL) connects the posterior vertebral end plate to the anterior vertebral end plate of adjacent vertebra. For example the IVL connects the posterior end plate of vertebra 14 to the anterior end plate of vertebra 15. It is typically composed of three distinct layers: the notochord sheet which is mainly type II collagen; the outer elastin layer; and a layer of type I collagen fiber bundles.(1)"

Description and comparison of mammalian and teleost intervertebral discs from ZDB-PUB-210902-3:
"Intervertebral discs (IVDs) connect consecutive vertebral bodies; their main function is mechanical, and they act as shock-absorbing cushions. Mammalian discs have an exquisite three-dimensional (3D) architecture comprised of the outer annulus fibrosus (AF) made from fibrocartilage and an inner region, the nucleus pulposus (NP). The NP is derived from the notochord; it contains chondrocyte-like cells and a gelatinous matrix composed of collagen type 2 and proteoglycans that are vital for the function of the discs and serve as a fluid-filled shock-absorbing cushion."
"In teleosts, the connections of the endplates of vertebral bodies are similar in design and function to mammalian IVD (hereafter called IVD). Centrally located vacuolated notochord cells with the same function as NP (hereafter called the NP) are surrounded by a strong composite ligament that functions like the AF (hereafter called the AF). The ligament is composed of, from inside to outside, collagen type II embedded in a matrix resembling cartilage, elastin, and collagen type 1 fiber bundles."
"In adult teleosts, vacuolated notochord cells turn into fibrous, keratinized, connective tissue (the septum and notochord strand) and extracellular vacuoles.
Disc damage and subsequent vertebral body fusion have been reported in farmed Atlantic salmon, suggesting that zebrafish could be a potential degenerative model for IVD"

This 2009 publication describes the development of the zebrafish intervertebral disc:
https://zfin.org/ZDB-PUB-090407-22

Examples:
Illustration in panel A https://zfin.org/ZDB-IMAGE-210327-79
Figure: https://zfin.org/ZDB-IMAGE-230529-54

@cerivs cerivs self-assigned this Sep 13, 2024
@cerivs
Copy link
Collaborator

cerivs commented Oct 28, 2024

@LeylaR I think the exact synonym for the IVL is the annulus fibrosus. Would you like a new term "intervertebral disc" that has multiple parts the IVL and whatever terms are needed to describe the notochord derivitives? or just a synonym for IVL "annulus fibrosus"?

@cerivs
Copy link
Collaborator

cerivs commented Oct 29, 2024

Added synonym to IVL. Keeping ticket open for other terms.

Sign up for free to join this conversation on GitHub. Already have an account? Sign in to comment
Labels
None yet
Projects
None yet
Development

No branches or pull requests

2 participants