diff --git a/lib/class-wp-duotone-gutenberg.php b/lib/class-wp-duotone-gutenberg.php
index 3544f580367101..45936e4b3e5473 100644
--- a/lib/class-wp-duotone-gutenberg.php
+++ b/lib/class-wp-duotone-gutenberg.php
@@ -115,7 +115,14 @@ public static function set_global_style_block_names() {
 				continue;
 			}
 			// If it has a duotone filter preset, save the block name and the preset slug.
-			$slug = self::gutenberg_get_slug_from_attr( $duotone_attr );
+			if ( is_string( $duotone_attr ) ) {
+				$slug = self::gutenberg_get_slug_from_attr( $duotone_attr );
+				// If the block has custom colors, we generate a slug for it and save it.
+			} else {
+				$slug = self::custom_unique_slug( $duotone_attr );
+				self::$global_styles_presets[ $slug ]['slug']   = $slug;
+				self::$global_styles_presets[ $slug ]['colors'] = $duotone_attr;
+			}
 
 			if ( $slug && $slug !== $duotone_attr ) {
 				self::$global_styles_block_names[ $block_node['name'] ] = $slug;
@@ -247,6 +254,16 @@ public static function output_global_styles() {
 		}
 	}
 
+	/**
+	 * Generate a unique slug for the filter based on the array of colors.
+	 *
+	 * @param string $duotone_attr The duotone attribute from a block.
+	 * @return string A unique string that defines the custom filter.
+	 */
+	public static function custom_unique_slug( $duotone_attr ) {
+		return wp_unique_id( sanitize_key( implode( '-', $duotone_attr ) . '-' ) );
+	}
+
 	/**
 	 * Render out the duotone CSS styles and SVG.
 	 *
@@ -304,8 +321,8 @@ public static function render_duotone_support( $block_content, $block ) {
 				// Pass through the CSS value.
 				$declaration_value = $duotone_attr;
 			} elseif ( $is_custom ) {
-				// Build a unique slug for the filter based on the array of colors.
-				$slug = wp_unique_id( sanitize_key( implode( '-', $duotone_attr ) . '-' ) );
+
+				$slug = self::custom_unique_slug( $duotone_attr );
 
 				$filter_data = array(
 					'slug'   => $slug,
diff --git a/packages/block-editor/src/components/global-styles/use-global-styles-output.js b/packages/block-editor/src/components/global-styles/use-global-styles-output.js
index cce2b61f0786e7..887b2e01b6840a 100644
--- a/packages/block-editor/src/components/global-styles/use-global-styles-output.js
+++ b/packages/block-editor/src/components/global-styles/use-global-styles-output.js
@@ -15,6 +15,7 @@ import {
 import { useSelect } from '@wordpress/data';
 import { useContext, useMemo } from '@wordpress/element';
 import { getCSSRules } from '@wordpress/style-engine';
+import { cleanForSlug } from '@wordpress/url';
 
 /**
  * Internal dependencies
@@ -23,7 +24,7 @@ import { PRESET_METADATA, ROOT_BLOCK_SELECTOR, scopeSelector } from './utils';
 import { getTypographyFontSizeValue } from './typography-utils';
 import { GlobalStylesContext } from './context';
 import { useGlobalSetting } from './hooks';
-import { PresetDuotoneFilter } from '../duotone/components';
+import { PresetDuotoneFilter, DuotoneFilter } from '../duotone/components';
 import { getGapCSSValue } from '../../hooks/gap';
 import { store as blockEditorStore } from '../../store';
 
@@ -260,11 +261,20 @@ export function getStylesDeclarations(
 				const cssProperty = key.startsWith( '--' )
 					? key
 					: kebabCase( key );
-				declarations.push(
-					`${ cssProperty }: ${ compileStyleValue(
-						get( blockStyles, pathToValue )
-					) }`
-				);
+
+				//The duotone filter is not one of the presets so we need to build the svg and the filter ID
+				if ( Array.isArray( blockStyles.filter?.duotone ) ) {
+					const slug = duotoneSlug( blockStyles.filter.duotone );
+					declarations.push(
+						`${ cssProperty }: url('#wp-duotone-${ slug }')`
+					);
+				} else {
+					declarations.push(
+						`${ cssProperty }: ${ compileStyleValue(
+							get( blockStyles, pathToValue )
+						) }`
+					);
+				}
 			}
 
 			return declarations;
@@ -900,6 +910,32 @@ export const toStyles = (
 	return ruleset;
 };
 
+function duotoneSlug( colors ) {
+	return colors
+		.map( ( x ) => cleanForSlug( x ).replaceAll( '-', '' ) )
+		.join( '-' );
+}
+
+export function customSvgFilters( tree, blockSelectors ) {
+	const nodesWithStyles = getNodesWithStyles( tree, blockSelectors );
+
+	return nodesWithStyles
+		.filter(
+			( { styles, duotoneSelector } ) =>
+				duotoneSelector && Array.isArray( styles.filter?.duotone )
+		)
+		.flatMap( ( node ) => {
+			const slug = duotoneSlug( node.styles.filter.duotone );
+			return (
+				<DuotoneFilter
+					key={ slug }
+					id={ `wp-duotone-${ slug }` }
+					colors={ node.styles.filter.duotone }
+				/>
+			);
+		} );
+}
+
 export function toSvgFilters( tree, blockSelectors ) {
 	const nodesWithSettings = getNodesWithSettings( tree, blockSelectors );
 	return nodesWithSettings.flatMap( ( { presets } ) => {
@@ -1050,7 +1086,9 @@ export function useGlobalStylesOutput() {
 			disableLayoutStyles
 		);
 
-		const filters = toSvgFilters( mergedConfig, blockSelectors );
+		const presetSvgs = toSvgFilters( mergedConfig, blockSelectors );
+		const customSvgs = customSvgFilters( mergedConfig, blockSelectors );
+
 		const stylesheets = [
 			{
 				css: customProperties,
@@ -1083,7 +1121,11 @@ export function useGlobalStylesOutput() {
 			}
 		} );
 
-		return [ stylesheets, mergedConfig.settings, filters ];
+		return [
+			stylesheets,
+			mergedConfig.settings,
+			[ ...presetSvgs, ...customSvgs ],
+		];
 	}, [
 		hasBlockGapSupport,
 		hasFallbackGapSupport,
diff --git a/packages/block-editor/src/components/global-styles/utils.js b/packages/block-editor/src/components/global-styles/utils.js
index 2ff2e732298044..3f34e1783930bb 100644
--- a/packages/block-editor/src/components/global-styles/utils.js
+++ b/packages/block-editor/src/components/global-styles/utils.js
@@ -15,6 +15,7 @@ export const ROOT_BLOCK_SUPPORTS = [
 	'background',
 	'backgroundColor',
 	'color',
+	'filter',
 	'linkColor',
 	'captionColor',
 	'buttonColor',
diff --git a/packages/blocks/src/store/private-selectors.js b/packages/blocks/src/store/private-selectors.js
index a50c82241dd12d..590422ccff99cc 100644
--- a/packages/blocks/src/store/private-selectors.js
+++ b/packages/blocks/src/store/private-selectors.js
@@ -14,6 +14,7 @@ const ROOT_BLOCK_SUPPORTS = [
 	'background',
 	'backgroundColor',
 	'color',
+	'filter',
 	'linkColor',
 	'captionColor',
 	'buttonColor',
diff --git a/packages/blocks/src/store/test/private-selectors.js b/packages/blocks/src/store/test/private-selectors.js
index 8eca5c2e859ea1..7e31e7c3e87621 100644
--- a/packages/blocks/src/store/test/private-selectors.js
+++ b/packages/blocks/src/store/test/private-selectors.js
@@ -29,6 +29,7 @@ describe( 'private selectors', () => {
 				'background',
 				'backgroundColor',
 				'color',
+				'filter',
 				'linkColor',
 				'captionColor',
 				'buttonColor',
@@ -51,6 +52,7 @@ describe( 'private selectors', () => {
 				'background',
 				'backgroundColor',
 				'color',
+				'filter',
 				'linkColor',
 				'captionColor',
 				'buttonColor',
@@ -78,6 +80,7 @@ describe( 'private selectors', () => {
 				'background',
 				'backgroundColor',
 				'color',
+				'filter',
 				'linkColor',
 				'captionColor',
 				'buttonColor',
diff --git a/packages/edit-site/src/components/global-styles/duotone-panel.js b/packages/edit-site/src/components/global-styles/duotone-panel.js
index c8cf095df4fe24..e1ce0c99fdfdcc 100644
--- a/packages/edit-site/src/components/global-styles/duotone-panel.js
+++ b/packages/edit-site/src/components/global-styles/duotone-panel.js
@@ -53,6 +53,11 @@ function DuotonePanel( { name } ) {
 		defaultSetting: 'color.defaultPalette',
 	} );
 
+	const disableCustomColors = ! useSetting( 'color.custom' );
+	const disableCustomDuotone =
+		! useSetting( 'color.customDuotone' ) ||
+		( colorPalette?.length === 0 && disableCustomColors );
+
 	if ( duotonePalette?.length === 0 ) {
 		return null;
 	}
@@ -68,8 +73,8 @@ function DuotonePanel( { name } ) {
 					<DuotonePicker
 						colorPalette={ colorPalette }
 						duotonePalette={ duotonePalette }
-						disableCustomColors={ true }
-						disableCustomDuotone={ true }
+						disableCustomColors={ disableCustomColors }
+						disableCustomDuotone={ disableCustomDuotone }
 						value={ themeDuotone }
 						onChange={ setThemeDuotone }
 					/>