diff --git a/packages/block-editor/src/components/duotone-control/index.js b/packages/block-editor/src/components/duotone-control/index.js
index 7682e7ee157e8d..e110286976b1a6 100644
--- a/packages/block-editor/src/components/duotone-control/index.js
+++ b/packages/block-editor/src/components/duotone-control/index.js
@@ -12,8 +12,10 @@ import {
 import { __ } from '@wordpress/i18n';
 import { DOWN } from '@wordpress/keycodes';
 import { Icon, filter } from '@wordpress/icons';
+import { useInstanceId } from '@wordpress/compose';
 
 function DuotoneControl( {
+	id: idProp,
 	colorPalette,
 	duotonePalette,
 	disableCustomColors,
@@ -31,6 +33,11 @@ function DuotoneControl( {
 	} else {
 		toolbarIcon = <Icon icon={ filter } />;
 	}
+
+	const actionLabel = __( 'Apply duotone filter' );
+	const id = useInstanceId( DuotoneControl, 'duotone-control', idProp );
+	const descriptionId = `${ id }__description`;
+
 	return (
 		<Dropdown
 			popoverProps={ {
@@ -51,19 +58,24 @@ function DuotoneControl( {
 						aria-haspopup="true"
 						aria-expanded={ isOpen }
 						onKeyDown={ openOnArrowDown }
-						label={ __( 'Apply duotone filter' ) }
+						label={ actionLabel }
 						icon={ toolbarIcon }
 					/>
 				);
 			} }
 			renderContent={ () => (
 				<MenuGroup label={ __( 'Duotone' ) }>
-					<div className="block-editor-duotone-control__description">
+					<div
+						id={ descriptionId }
+						className="block-editor-duotone-control__description"
+					>
 						{ __(
 							'Create a two-tone color effect without losing your original image.'
 						) }
 					</div>
 					<DuotonePicker
+						aria-label={ actionLabel }
+						aria-describedby={ descriptionId }
 						colorPalette={ colorPalette }
 						duotonePalette={ duotonePalette }
 						disableCustomColors={ disableCustomColors }
diff --git a/packages/components/CHANGELOG.md b/packages/components/CHANGELOG.md
index 02038f6b384510..39c6c6afc42d55 100644
--- a/packages/components/CHANGELOG.md
+++ b/packages/components/CHANGELOG.md
@@ -6,6 +6,7 @@
 
 -   `SearchControl`: polish metrics for `compact` size variant ([#54663](https://github.com/WordPress/gutenberg/pull/54663)).
 -   `Button`: deprecating `isPressed` prop in favour of `aria-pressed` ([#54740](https://github.com/WordPress/gutenberg/pull/54740)).
+-   `DuotonePicker/ColorListPicker`: Adds appropriate label and description to 'Duotone Filter' picker ([#54473](https://github.com/WordPress/gutenberg/pull/54473)).
 
 ### Bug Fix
 
@@ -39,7 +40,7 @@
 -   `DuotonePicker/ColorListPicker`: Adds appropriate labels to 'Duotone Filter' color pickers ([#54468](https://github.com/WordPress/gutenberg/pull/54468)).
 -   `SearchControl`: support new `40px` and `32px` sizes ([#54548](https://github.com/WordPress/gutenberg/pull/54548)).
 -   `FormTokenField`: Add `tokenizeOnBlur` prop to add any incompleteTokenValue as a new token when field loses focus ([#54445](https://github.com/WordPress/gutenberg/pull/54445)).
-- `Sandbox`: Add `tabIndex` prop ([#54408](https://github.com/WordPress/gutenberg/pull/54408)).
+-   `Sandbox`: Add `tabIndex` prop ([#54408](https://github.com/WordPress/gutenberg/pull/54408)).
 
 ### Bug Fix
 
diff --git a/packages/components/src/duotone-picker/duotone-picker.tsx b/packages/components/src/duotone-picker/duotone-picker.tsx
index 70e5753175eac0..759c517b4759e1 100644
--- a/packages/components/src/duotone-picker/duotone-picker.tsx
+++ b/packages/components/src/duotone-picker/duotone-picker.tsx
@@ -67,6 +67,7 @@ function DuotonePicker( {
 	onChange,
 	'aria-label': ariaLabel,
 	'aria-labelledby': ariaLabelledby,
+	...otherProps
 }: DuotonePickerProps ) {
 	const [ defaultDark, defaultLight ] = useMemo(
 		() => getDefaultColors( colorPalette ),
@@ -74,13 +75,15 @@ function DuotonePicker( {
 	);
 
 	const isUnset = value === 'unset';
+	const unsetOptionLabel = __( 'Unset' );
 
 	const unsetOption = (
 		<CircularOptionPicker.Option
 			key="unset"
 			value="unset"
 			isSelected={ isUnset }
-			tooltipText={ __( 'Unset' ) }
+			tooltipText={ unsetOptionLabel }
+			aria-label={ unsetOptionLabel }
 			className="components-duotone-picker__color-indicator"
 			onClick={ () => {
 				onChange( isUnset ? undefined : 'unset' );
@@ -154,6 +157,7 @@ function DuotonePicker( {
 
 	return (
 		<CircularOptionPicker
+			{ ...otherProps }
 			{ ...metaProps }
 			options={ unsetable ? [ unsetOption, ...options ] : options }
 			actions={